

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosome assembly (GO:0042255) | 4.99764007 |
| 2 | nucleobase biosynthetic process (GO:0046112) | 4.84830626 |
| 3 | purine nucleobase biosynthetic process (GO:0009113) | 4.82702415 |
| 4 | formation of translation preinitiation complex (GO:0001731) | 4.63125393 |
| 5 | DNA deamination (GO:0045006) | 4.46308635 |
| 6 | DNA replication initiation (GO:0006270) | 4.41114399 |
| 7 | mitotic metaphase plate congression (GO:0007080) | 4.39805422 |
| 8 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.37031604 |
| 9 | ribosome biogenesis (GO:0042254) | 4.34439463 |
| 10 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.29589274 |
| 11 | maturation of SSU-rRNA (GO:0030490) | 4.26462754 |
| 12 | DNA strand elongation (GO:0022616) | 4.15252354 |
| 13 | DNA replication checkpoint (GO:0000076) | 4.14368857 |
| 14 | proteasome assembly (GO:0043248) | 4.09411355 |
| 15 | IMP biosynthetic process (GO:0006188) | 4.06859968 |
| 16 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 4.03362488 |
| 17 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 4.03362488 |
| 18 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 4.03362488 |
| 19 | non-recombinational repair (GO:0000726) | 4.02634184 |
| 20 | double-strand break repair via nonhomologous end joining (GO:0006303) | 4.02634184 |
| 21 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.95968823 |
| 22 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.94797200 |
| 23 | ribosomal large subunit biogenesis (GO:0042273) | 3.90534721 |
| 24 | folic acid metabolic process (GO:0046655) | 3.90204840 |
| 25 | positive regulation of chromosome segregation (GO:0051984) | 3.79854761 |
| 26 | CENP-A containing nucleosome assembly (GO:0034080) | 3.79230702 |
| 27 | chromatin remodeling at centromere (GO:0031055) | 3.74889076 |
| 28 | DNA unwinding involved in DNA replication (GO:0006268) | 3.71560110 |
| 29 | IMP metabolic process (GO:0046040) | 3.70647974 |
| 30 | protein localization to kinetochore (GO:0034501) | 3.69729100 |
| 31 | rRNA modification (GO:0000154) | 3.69244110 |
| 32 | mitochondrial RNA metabolic process (GO:0000959) | 3.68984125 |
| 33 | mitotic nuclear envelope disassembly (GO:0007077) | 3.67865746 |
| 34 | regulation of sister chromatid cohesion (GO:0007063) | 3.65508862 |
| 35 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.64664689 |
| 36 | spliceosomal snRNP assembly (GO:0000387) | 3.64405311 |
| 37 | rRNA processing (GO:0006364) | 3.63011338 |
| 38 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.61752634 |
| 39 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.61752634 |
| 40 | prenylation (GO:0097354) | 3.60753588 |
| 41 | protein prenylation (GO:0018342) | 3.60753588 |
| 42 | metaphase plate congression (GO:0051310) | 3.60112860 |
| 43 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.57796030 |
| 44 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.56675191 |
| 45 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.55600467 |
| 46 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.55292904 |
| 47 | telomere maintenance via recombination (GO:0000722) | 3.54837355 |
| 48 | regulation of mitochondrial translation (GO:0070129) | 3.52123053 |
| 49 | rRNA metabolic process (GO:0016072) | 3.49633932 |
| 50 | pseudouridine synthesis (GO:0001522) | 3.48611357 |
| 51 | regulation of spindle organization (GO:0090224) | 3.47096800 |
| 52 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.43304743 |
| 53 | DNA replication-independent nucleosome organization (GO:0034724) | 3.43304743 |
| 54 | membrane disassembly (GO:0030397) | 3.41562137 |
| 55 | nuclear envelope disassembly (GO:0051081) | 3.41562137 |
| 56 | translational initiation (GO:0006413) | 3.40122224 |
| 57 | translational termination (GO:0006415) | 3.32135737 |
| 58 | ribosomal small subunit assembly (GO:0000028) | 3.31183393 |
| 59 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.31162553 |
| 60 | negative regulation of ligase activity (GO:0051352) | 3.31162553 |
| 61 | mitotic recombination (GO:0006312) | 3.29398644 |
| 62 | ribosomal small subunit biogenesis (GO:0042274) | 3.28381361 |
| 63 | nuclear pore organization (GO:0006999) | 3.28019024 |
| 64 | viral transcription (GO:0019083) | 3.25280808 |
| 65 | termination of RNA polymerase III transcription (GO:0006386) | 3.24623127 |
| 66 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.24623127 |
| 67 | tRNA aminoacylation (GO:0043039) | 3.24591976 |
| 68 | amino acid activation (GO:0043038) | 3.24591976 |
| 69 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.24515142 |
| 70 | tRNA aminoacylation for protein translation (GO:0006418) | 3.24431148 |
| 71 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.23622961 |
| 72 | telomere maintenance via telomere lengthening (GO:0010833) | 3.23548477 |
| 73 | protein targeting to mitochondrion (GO:0006626) | 3.22452921 |
| 74 | protein localization to chromosome, centromeric region (GO:0071459) | 3.21656211 |
| 75 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.20862871 |
| 76 | cell cycle G1/S phase transition (GO:0044843) | 3.20862871 |
| 77 | rRNA methylation (GO:0031167) | 3.19341237 |
| 78 | translational elongation (GO:0006414) | 3.14983080 |
| 79 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.14662325 |
| 80 | establishment of chromosome localization (GO:0051303) | 3.11832681 |
| 81 | histone exchange (GO:0043486) | 3.11651841 |
| 82 | positive regulation of ligase activity (GO:0051351) | 3.11251174 |
| 83 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.10660040 |
| 84 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.08053946 |
| 85 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.07973218 |
| 86 | DNA damage response, detection of DNA damage (GO:0042769) | 3.07962271 |
| 87 | maturation of 5.8S rRNA (GO:0000460) | 3.07455313 |
| 88 | regulation of translational termination (GO:0006449) | 3.07031040 |
| 89 | chaperone-mediated protein transport (GO:0072321) | 3.06085127 |
| 90 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.05220306 |
| 91 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.05220306 |
| 92 | cullin deneddylation (GO:0010388) | 3.04557188 |
| 93 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.04302862 |
| 94 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.04302862 |
| 95 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.02988649 |
| 96 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.02988649 |
| 97 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.02988649 |
| 98 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.02060581 |
| 99 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.02060581 |
| 100 | cellular component biogenesis (GO:0044085) | 3.01871565 |
| 101 | establishment of protein localization to mitochondrion (GO:0072655) | 3.01467856 |
| 102 | translation (GO:0006412) | 3.00723862 |
| 103 | establishment of viral latency (GO:0019043) | 3.00120951 |
| 104 | 7-methylguanosine mRNA capping (GO:0006370) | 2.99695844 |
| 105 | tRNA metabolic process (GO:0006399) | 2.98301943 |
| 106 | protein deneddylation (GO:0000338) | 2.98127915 |
| 107 | protein localization to mitochondrion (GO:0070585) | 2.97877366 |
| 108 | termination of RNA polymerase I transcription (GO:0006363) | 2.97249850 |
| 109 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.96590360 |
| 110 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.96360399 |
| 111 | ncRNA metabolic process (GO:0034660) | 2.96052767 |
| 112 | glycine metabolic process (GO:0006544) | 2.95707669 |
| 113 | ncRNA processing (GO:0034470) | 2.94046967 |
| 114 | transcription from RNA polymerase I promoter (GO:0006360) | 2.92953560 |
| 115 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.92837507 |
| 116 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.92553650 |
| 117 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.92553650 |
| 118 | RNA capping (GO:0036260) | 2.92470753 |
| 119 | 7-methylguanosine RNA capping (GO:0009452) | 2.92470753 |
| 120 | kinetochore organization (GO:0051383) | 2.92288549 |
| 121 | peptidyl-histidine modification (GO:0018202) | 2.91013367 |
| 122 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.90318600 |
| 123 | telomere organization (GO:0032200) | 2.90204740 |
| 124 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.89554911 |
| 125 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.89357692 |
| 126 | regulation of mitotic spindle organization (GO:0060236) | 2.88967198 |
| 127 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.88549958 |
| 128 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.88510468 |
| 129 | establishment of integrated proviral latency (GO:0075713) | 2.87614221 |
| 130 | L-serine metabolic process (GO:0006563) | 2.87176729 |
| 131 | nuclear pore complex assembly (GO:0051292) | 2.86492469 |
| 132 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.86014476 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.82507223 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.56453531 |
| 3 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.87036901 |
| 4 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.44587474 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.26387894 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.16312568 |
| 7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.12393392 |
| 8 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.10315449 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.07323080 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.05048716 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.03346477 |
| 12 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.01432936 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.99752789 |
| 14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.96504942 |
| 15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.65519086 |
| 16 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.51707494 |
| 17 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.49477625 |
| 18 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.36974723 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.35478434 |
| 20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.33505373 |
| 21 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.27804327 |
| 22 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.25865082 |
| 23 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.22025527 |
| 24 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.18730243 |
| 25 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.16941666 |
| 26 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.00935974 |
| 27 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.98943909 |
| 28 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.97415109 |
| 29 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.90131624 |
| 30 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.89228548 |
| 31 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.87497099 |
| 32 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.85580315 |
| 33 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.84766699 |
| 34 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.81487612 |
| 35 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.79841395 |
| 36 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.78806434 |
| 37 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.73335072 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.72749342 |
| 39 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.70357627 |
| 40 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.65356088 |
| 41 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.62750661 |
| 42 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.61900910 |
| 43 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.61768234 |
| 44 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.56535206 |
| 45 | VDR_22108803_ChIP-Seq_LS180_Human | 1.54519739 |
| 46 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.52940322 |
| 47 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.52409938 |
| 48 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.51815914 |
| 49 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.48410109 |
| 50 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.47930156 |
| 51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.46167118 |
| 52 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.44435192 |
| 53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44258325 |
| 54 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.42069793 |
| 55 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.40612565 |
| 56 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.37239636 |
| 57 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.33731364 |
| 58 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.33301536 |
| 59 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.28099244 |
| 60 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27785496 |
| 61 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.23130819 |
| 62 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21508197 |
| 63 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.21299100 |
| 64 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.20763776 |
| 65 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.17864499 |
| 66 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.16843147 |
| 67 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.15834331 |
| 68 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.12411080 |
| 69 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12212747 |
| 70 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.12077990 |
| 71 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.10856879 |
| 72 | MYC_22102868_ChIP-Seq_BL_Human | 1.09000470 |
| 73 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.06079909 |
| 74 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.05850930 |
| 75 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.05780025 |
| 76 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.05649048 |
| 77 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.05462067 |
| 78 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.05305552 |
| 79 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.04635950 |
| 80 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.03200579 |
| 81 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.02524848 |
| 82 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.00969185 |
| 83 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.00363005 |
| 84 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.99728053 |
| 85 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.99458768 |
| 86 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.98428601 |
| 87 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.97734768 |
| 88 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.97124810 |
| 89 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.97002454 |
| 90 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.95866748 |
| 91 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.93740065 |
| 92 | EWS_26573619_Chip-Seq_HEK293_Human | 0.92215931 |
| 93 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.91781133 |
| 94 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.91374121 |
| 95 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.90680019 |
| 96 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.89475729 |
| 97 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.88860233 |
| 98 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.88654016 |
| 99 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.87673382 |
| 100 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.85689784 |
| 101 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.85391784 |
| 102 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.84114569 |
| 103 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.83178849 |
| 104 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.82573971 |
| 105 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.81514898 |
| 106 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.80657686 |
| 107 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.80591719 |
| 108 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.79564662 |
| 109 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.79206457 |
| 110 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.79131431 |
| 111 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.79127727 |
| 112 | GATA1_22025678_ChIP-Seq_K562_Human | 0.78273396 |
| 113 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.76465053 |
| 114 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.73738853 |
| 115 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.71687967 |
| 116 | FUS_26573619_Chip-Seq_HEK293_Human | 0.70369355 |
| 117 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.68442106 |
| 118 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.66190574 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 6.01930784 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.78874401 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 4.33390332 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.20005025 |
| 5 | MP0003111_abnormal_nucleus_morphology | 4.17966223 |
| 6 | MP0003077_abnormal_cell_cycle | 3.82902136 |
| 7 | MP0008057_abnormal_DNA_replication | 3.41541531 |
| 8 | MP0008058_abnormal_DNA_repair | 3.11993672 |
| 9 | MP0000566_synostosis | 2.90989362 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.79906194 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.75077920 |
| 12 | MP0001730_embryonic_growth_arrest | 2.59789959 |
| 13 | MP0003718_maternal_effect | 2.42969058 |
| 14 | MP0010352_gastrointestinal_tract_polyps | 2.30429973 |
| 15 | MP0000350_abnormal_cell_proliferation | 2.24784395 |
| 16 | MP0003123_paternal_imprinting | 2.15839879 |
| 17 | MP0003186_abnormal_redox_activity | 2.05479502 |
| 18 | MP0010307_abnormal_tumor_latency | 1.93402249 |
| 19 | MP0002938_white_spotting | 1.86239952 |
| 20 | MP0003786_premature_aging | 1.82828530 |
| 21 | MP0001697_abnormal_embryo_size | 1.77334963 |
| 22 | MP0001672_abnormal_embryogenesis/_devel | 1.75984946 |
| 23 | MP0005380_embryogenesis_phenotype | 1.75984946 |
| 24 | MP0000372_irregular_coat_pigmentation | 1.74964040 |
| 25 | MP0002396_abnormal_hematopoietic_system | 1.65844482 |
| 26 | MP0002080_prenatal_lethality | 1.65168626 |
| 27 | MP0009333_abnormal_splenocyte_physiolog | 1.60853965 |
| 28 | MP0003984_embryonic_growth_retardation | 1.60444728 |
| 29 | MP0002088_abnormal_embryonic_growth/wei | 1.56445548 |
| 30 | MP0002163_abnormal_gland_morphology | 1.55072960 |
| 31 | MP0001529_abnormal_vocalization | 1.50200550 |
| 32 | MP0000490_abnormal_crypts_of | 1.44475362 |
| 33 | MP0003136_yellow_coat_color | 1.42140950 |
| 34 | MP0006036_abnormal_mitochondrial_physio | 1.41853580 |
| 35 | MP0002102_abnormal_ear_morphology | 1.39309688 |
| 36 | MP0002085_abnormal_embryonic_tissue | 1.38181953 |
| 37 | MP0000313_abnormal_cell_death | 1.35511498 |
| 38 | MP0002019_abnormal_tumor_incidence | 1.35318074 |
| 39 | MP0009840_abnormal_foam_cell | 1.34551968 |
| 40 | MP0003221_abnormal_cardiomyocyte_apopto | 1.33176779 |
| 41 | MP0002086_abnormal_extraembryonic_tissu | 1.31705030 |
| 42 | MP0000358_abnormal_cell_content/ | 1.30965830 |
| 43 | MP0004197_abnormal_fetal_growth/weight/ | 1.30323815 |
| 44 | MP0006292_abnormal_olfactory_placode | 1.29169120 |
| 45 | MP0002084_abnormal_developmental_patter | 1.29102281 |
| 46 | MP0005084_abnormal_gallbladder_morpholo | 1.26918918 |
| 47 | MP0001919_abnormal_reproductive_system | 1.26879349 |
| 48 | MP0008789_abnormal_olfactory_epithelium | 1.20974970 |
| 49 | MP0002751_abnormal_autonomic_nervous | 1.20484258 |
| 50 | MP0006072_abnormal_retinal_apoptosis | 1.20218367 |
| 51 | MP0006035_abnormal_mitochondrial_morpho | 1.19859597 |
| 52 | MP0003567_abnormal_fetal_cardiomyocyte | 1.18619030 |
| 53 | MP0010030_abnormal_orbit_morphology | 1.17632547 |
| 54 | MP0003705_abnormal_hypodermis_morpholog | 1.13141548 |
| 55 | MP0005501_abnormal_skin_physiology | 1.10706453 |
| 56 | MP0001293_anophthalmia | 1.09354241 |
| 57 | MP0000750_abnormal_muscle_regeneration | 1.08882676 |
| 58 | MP0008877_abnormal_DNA_methylation | 1.08066034 |
| 59 | MP0001286_abnormal_eye_development | 1.03024899 |
| 60 | MP0005266_abnormal_metabolism | 0.98279485 |
| 61 | MP0002160_abnormal_reproductive_system | 0.98173538 |
| 62 | MP0005408_hypopigmentation | 0.97909607 |
| 63 | MP0005379_endocrine/exocrine_gland_phen | 0.96902653 |
| 64 | MP0001881_abnormal_mammary_gland | 0.96557931 |
| 65 | MP0000467_abnormal_esophagus_morphology | 0.96472022 |
| 66 | MP0002210_abnormal_sex_determination | 0.96440598 |
| 67 | MP0000647_abnormal_sebaceous_gland | 0.96334613 |
| 68 | MP0001145_abnormal_male_reproductive | 0.93743354 |
| 69 | MP0003195_calcinosis | 0.91520712 |
| 70 | MP0009672_abnormal_birth_weight | 0.90547659 |
| 71 | MP0003950_abnormal_plasma_membrane | 0.87444162 |
| 72 | MP0005023_abnormal_wound_healing | 0.86958844 |
| 73 | MP0002132_abnormal_respiratory_system | 0.86861380 |
| 74 | MP0008260_abnormal_autophagy | 0.86224732 |
| 75 | MP0005253_abnormal_eye_physiology | 0.85624639 |
| 76 | MP0000858_altered_metastatic_potential | 0.83796673 |
| 77 | MP0001853_heart_inflammation | 0.83113681 |
| 78 | MP0003656_abnormal_erythrocyte_physiolo | 0.83078181 |
| 79 | MP0005397_hematopoietic_system_phenotyp | 0.82277171 |
| 80 | MP0001545_abnormal_hematopoietic_system | 0.82277171 |
| 81 | MP0009053_abnormal_anal_canal | 0.81915349 |
| 82 | MP0005384_cellular_phenotype | 0.81879395 |
| 83 | MP0004233_abnormal_muscle_weight | 0.80915494 |
| 84 | MP0003890_abnormal_embryonic-extraembry | 0.80550701 |
| 85 | MP0001764_abnormal_homeostasis | 0.79447578 |
| 86 | MP0005389_reproductive_system_phenotype | 0.77574071 |
| 87 | MP0005395_other_phenotype | 0.77527864 |
| 88 | MP0002837_dystrophic_cardiac_calcinosis | 0.77090221 |
| 89 | MP0004133_heterotaxia | 0.76767775 |
| 90 | MP0002697_abnormal_eye_size | 0.76099965 |
| 91 | MP0000653_abnormal_sex_gland | 0.75930371 |
| 92 | MP0000689_abnormal_spleen_morphology | 0.75134499 |
| 93 | MP0003315_abnormal_perineum_morphology | 0.75018106 |
| 94 | MP0000383_abnormal_hair_follicle | 0.74079994 |
| 95 | MP0005621_abnormal_cell_physiology | 0.73976671 |
| 96 | MP0002111_abnormal_tail_morphology | 0.73802659 |
| 97 | MP0002736_abnormal_nociception_after | 0.73062675 |
| 98 | MP0004147_increased_porphyrin_level | 0.72776675 |
| 99 | MP0002722_abnormal_immune_system | 0.72764207 |
| 100 | MP0000598_abnormal_liver_morphology | 0.72569082 |
| 101 | MP0001661_extended_life_span | 0.71953767 |
| 102 | MP0003941_abnormal_skin_development | 0.71212010 |
| 103 | MP0001929_abnormal_gametogenesis | 0.71024996 |
| 104 | MP0002269_muscular_atrophy | 0.70225816 |
| 105 | MP0009697_abnormal_copulation | 0.68290939 |
| 106 | MP0001542_abnormal_bone_strength | 0.68263792 |
| 107 | MP0002233_abnormal_nose_morphology | 0.67736337 |
| 108 | MP0004808_abnormal_hematopoietic_stem | 0.66897006 |
| 109 | MP0005391_vision/eye_phenotype | 0.64876615 |
| 110 | MP0010678_abnormal_skin_adnexa | 0.64716699 |
| 111 | MP0001915_intracranial_hemorrhage | 0.64034798 |
| 112 | MP0006054_spinal_hemorrhage | 0.63694105 |
| 113 | MP0002653_abnormal_ependyma_morphology | 0.63326613 |
| 114 | MP0003119_abnormal_digestive_system | 0.63287200 |
| 115 | MP0002398_abnormal_bone_marrow | 0.62662695 |
| 116 | MP0001119_abnormal_female_reproductive | 0.62633390 |
| 117 | MP0000703_abnormal_thymus_morphology | 0.61955668 |
| 118 | MP0005319_abnormal_enzyme/_coenzyme | 0.61621134 |
| 119 | MP0001727_abnormal_embryo_implantation | 0.60878775 |
| 120 | MP0002090_abnormal_vision | 0.60162436 |
| 121 | MP0000537_abnormal_urethra_morphology | 0.59664993 |
| 122 | MP0003646_muscle_fatigue | 0.59243393 |
| 123 | MP0005332_abnormal_amino_acid | 0.59179632 |
| 124 | MP0003698_abnormal_male_reproductive | 0.58944208 |
| 125 | MP0004215_abnormal_myocardial_fiber | 0.58709158 |
| 126 | MP0000049_abnormal_middle_ear | 0.58653735 |
| 127 | MP0002254_reproductive_system_inflammat | 0.58300783 |
| 128 | MP0002161_abnormal_fertility/fecundity | 0.58283552 |
| 129 | MP0005410_abnormal_fertilization | 0.57807732 |
| 130 | MP0005075_abnormal_melanosome_morpholog | 0.57669613 |
| 131 | MP0004084_abnormal_cardiac_muscle | 0.57315126 |
| 132 | MP0000627_abnormal_mammary_gland | 0.57173464 |
| 133 | MP0002429_abnormal_blood_cell | 0.57008669 |
| 134 | MP0000477_abnormal_intestine_morphology | 0.56746983 |
| 135 | MP0003566_abnormal_cell_adhesion | 0.55907537 |
| 136 | MP0003763_abnormal_thymus_physiology | 0.55866470 |
| 137 | MP0002139_abnormal_hepatobiliary_system | 0.54178002 |
| 138 | MP0003937_abnormal_limbs/digits/tail_de | 0.53680051 |
| 139 | MP0002092_abnormal_eye_morphology | 0.53249006 |
| 140 | MP0005360_urolithiasis | 0.52580804 |
| 141 | MP0005076_abnormal_cell_differentiation | 0.52355019 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.79981294 |
| 2 | Breast hypoplasia (HP:0003187) | 4.60692086 |
| 3 | Oral leukoplakia (HP:0002745) | 3.99174750 |
| 4 | Cerebral hypomyelination (HP:0006808) | 3.99039893 |
| 5 | Carpal bone hypoplasia (HP:0001498) | 3.89927391 |
| 6 | Rough bone trabeculation (HP:0100670) | 3.87674941 |
| 7 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.72631721 |
| 8 | Reticulocytopenia (HP:0001896) | 3.57304000 |
| 9 | Acute necrotizing encephalopathy (HP:0006965) | 3.52160449 |
| 10 | Degeneration of anterior horn cells (HP:0002398) | 3.48515123 |
| 11 | Abnormality of the anterior horn cell (HP:0006802) | 3.48515123 |
| 12 | Abnormal number of erythroid precursors (HP:0012131) | 3.40800054 |
| 13 | Multiple enchondromatosis (HP:0005701) | 3.37806701 |
| 14 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.27895024 |
| 15 | Acute encephalopathy (HP:0006846) | 3.26841613 |
| 16 | Duplicated collecting system (HP:0000081) | 3.18058427 |
| 17 | Increased hepatocellular lipid droplets (HP:0006565) | 3.13712443 |
| 18 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.03320285 |
| 19 | Abnormality of glycolysis (HP:0004366) | 2.99987586 |
| 20 | Increased serum pyruvate (HP:0003542) | 2.99987586 |
| 21 | Mitochondrial inheritance (HP:0001427) | 2.98147540 |
| 22 | Microvesicular hepatic steatosis (HP:0001414) | 2.96486094 |
| 23 | Macrocytic anemia (HP:0001972) | 2.94561158 |
| 24 | Trismus (HP:0000211) | 2.93326289 |
| 25 | Lactic acidosis (HP:0003128) | 2.89193155 |
| 26 | Lipid accumulation in hepatocytes (HP:0006561) | 2.89118457 |
| 27 | Patellar aplasia (HP:0006443) | 2.88343691 |
| 28 | Abnormality of the renal collecting system (HP:0004742) | 2.87124568 |
| 29 | Colon cancer (HP:0003003) | 2.84964192 |
| 30 | Abnormal trabecular bone morphology (HP:0100671) | 2.84318027 |
| 31 | Selective tooth agenesis (HP:0001592) | 2.82291535 |
| 32 | Hepatocellular necrosis (HP:0001404) | 2.80329952 |
| 33 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.74118306 |
| 34 | Abnormal protein glycosylation (HP:0012346) | 2.73818625 |
| 35 | Abnormal glycosylation (HP:0012345) | 2.73818625 |
| 36 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.73818625 |
| 37 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.73818625 |
| 38 | Microretrognathia (HP:0000308) | 2.72226648 |
| 39 | Absent radius (HP:0003974) | 2.72185906 |
| 40 | Progressive macrocephaly (HP:0004481) | 2.71561284 |
| 41 | Premature ovarian failure (HP:0008209) | 2.67866137 |
| 42 | Megaloblastic anemia (HP:0001889) | 2.67723730 |
| 43 | Hyperglycinemia (HP:0002154) | 2.66139731 |
| 44 | Progressive muscle weakness (HP:0003323) | 2.64741569 |
| 45 | Hypoplastic pelvis (HP:0008839) | 2.62734436 |
| 46 | Secondary amenorrhea (HP:0000869) | 2.61788695 |
| 47 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.61561902 |
| 48 | Abnormality of alanine metabolism (HP:0010916) | 2.57383864 |
| 49 | Hyperalaninemia (HP:0003348) | 2.57383864 |
| 50 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.57383864 |
| 51 | Agnosia (HP:0010524) | 2.56935631 |
| 52 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.53069132 |
| 53 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.53069132 |
| 54 | Abnormality of the pons (HP:0007361) | 2.52154210 |
| 55 | Aplasia involving forearm bones (HP:0009822) | 2.51323415 |
| 56 | Absent forearm bone (HP:0003953) | 2.51323415 |
| 57 | Cerebral edema (HP:0002181) | 2.50876106 |
| 58 | Aplastic anemia (HP:0001915) | 2.49131654 |
| 59 | Hypoplasia of the pons (HP:0012110) | 2.48641324 |
| 60 | Neoplasm of the pancreas (HP:0002894) | 2.47509903 |
| 61 | CNS hypomyelination (HP:0003429) | 2.46173687 |
| 62 | Ependymoma (HP:0002888) | 2.45126327 |
| 63 | Premature graying of hair (HP:0002216) | 2.44937295 |
| 64 | Impulsivity (HP:0100710) | 2.44790699 |
| 65 | Abnormality of methionine metabolism (HP:0010901) | 2.42522328 |
| 66 | Increased serum lactate (HP:0002151) | 2.42146614 |
| 67 | Meckel diverticulum (HP:0002245) | 2.41283086 |
| 68 | Abnormality of the preputium (HP:0100587) | 2.39283039 |
| 69 | Absent thumb (HP:0009777) | 2.38876169 |
| 70 | Long foot (HP:0001833) | 2.38195317 |
| 71 | Pallor (HP:0000980) | 2.34857523 |
| 72 | Abnormality of chromosome stability (HP:0003220) | 2.34259658 |
| 73 | Large for gestational age (HP:0001520) | 2.33892815 |
| 74 | Reduced antithrombin III activity (HP:0001976) | 2.32925052 |
| 75 | Postnatal microcephaly (HP:0005484) | 2.32439830 |
| 76 | Abnormality of serum amino acid levels (HP:0003112) | 2.31147983 |
| 77 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.27373373 |
| 78 | Chromsome breakage (HP:0040012) | 2.26661801 |
| 79 | Glossoptosis (HP:0000162) | 2.25473373 |
| 80 | Abnormality of the ileum (HP:0001549) | 2.24584514 |
| 81 | Horseshoe kidney (HP:0000085) | 2.23085916 |
| 82 | Abnormality of the umbilical cord (HP:0010881) | 2.22327976 |
| 83 | Sparse eyelashes (HP:0000653) | 2.20823954 |
| 84 | Cellular immunodeficiency (HP:0005374) | 2.19883516 |
| 85 | Hyperglycinuria (HP:0003108) | 2.16882577 |
| 86 | Bone marrow hypocellularity (HP:0005528) | 2.16839896 |
| 87 | Exercise intolerance (HP:0003546) | 2.16745717 |
| 88 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.13457817 |
| 89 | Rhabdomyosarcoma (HP:0002859) | 2.12866022 |
| 90 | Medulloblastoma (HP:0002885) | 2.12301677 |
| 91 | Respiratory failure (HP:0002878) | 2.10804107 |
| 92 | Ureteral duplication (HP:0000073) | 2.06832279 |
| 93 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.03661505 |
| 94 | Poor head control (HP:0002421) | 2.03506966 |
| 95 | Abnormality of the labia minora (HP:0012880) | 2.03482498 |
| 96 | Renal Fanconi syndrome (HP:0001994) | 2.03463278 |
| 97 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.03245371 |
| 98 | Abnormality of glycine metabolism (HP:0010895) | 2.03245371 |
| 99 | Nausea (HP:0002018) | 2.03020059 |
| 100 | Clubbing of toes (HP:0100760) | 2.02437373 |
| 101 | Pancytopenia (HP:0001876) | 2.02056710 |
| 102 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.01540355 |
| 103 | Supernumerary spleens (HP:0009799) | 2.01345218 |
| 104 | Abnormal lung lobation (HP:0002101) | 1.97841422 |
| 105 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.96867800 |
| 106 | CNS demyelination (HP:0007305) | 1.95491907 |
| 107 | Hypobetalipoproteinemia (HP:0003563) | 1.92346501 |
| 108 | Increased intramyocellular lipid droplets (HP:0012240) | 1.92106553 |
| 109 | Personality changes (HP:0000751) | 1.91182748 |
| 110 | Cleft eyelid (HP:0000625) | 1.91142189 |
| 111 | Death in infancy (HP:0001522) | 1.89961991 |
| 112 | Irregular epiphyses (HP:0010582) | 1.89741876 |
| 113 | Slender long bone (HP:0003100) | 1.88456928 |
| 114 | Abnormality of the carotid arteries (HP:0005344) | 1.87746670 |
| 115 | Brushfield spots (HP:0001088) | 1.86762905 |
| 116 | Stenosis of the external auditory canal (HP:0000402) | 1.86660277 |
| 117 | Abnormality of the duodenum (HP:0002246) | 1.86610276 |
| 118 | Atresia of the external auditory canal (HP:0000413) | 1.86554682 |
| 119 | Myelodysplasia (HP:0002863) | 1.86386332 |
| 120 | Small intestinal stenosis (HP:0012848) | 1.86213678 |
| 121 | Duodenal stenosis (HP:0100867) | 1.86213678 |
| 122 | Spinal muscular atrophy (HP:0007269) | 1.84077298 |
| 123 | Increased CSF lactate (HP:0002490) | 1.83840863 |
| 124 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.83511219 |
| 125 | Methylmalonic aciduria (HP:0012120) | 1.83470841 |
| 126 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.81221937 |
| 127 | Type I transferrin isoform profile (HP:0003642) | 1.81154457 |
| 128 | Triphalangeal thumb (HP:0001199) | 1.80630182 |
| 129 | Squamous cell carcinoma (HP:0002860) | 1.80025747 |
| 130 | 3-Methylglutaconic aciduria (HP:0003535) | 1.79852556 |
| 131 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.79757184 |
| 132 | Hepatic necrosis (HP:0002605) | 1.79670115 |
| 133 | Entropion (HP:0000621) | 1.77241086 |
| 134 | Leukodystrophy (HP:0002415) | 1.77048796 |
| 135 | Rhabdomyolysis (HP:0003201) | 1.76821801 |
| 136 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.76511689 |
| 137 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.75309774 |
| 138 | Sloping forehead (HP:0000340) | 1.74079367 |
| 139 | Severe muscular hypotonia (HP:0006829) | 1.72695662 |
| 140 | Lethargy (HP:0001254) | 1.71313392 |
| 141 | Dry hair (HP:0011359) | 1.69686814 |
| 142 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.69568027 |
| 143 | Respiratory difficulties (HP:0002880) | 1.69561373 |
| 144 | Tracheoesophageal fistula (HP:0002575) | 1.69453795 |
| 145 | Methylmalonic acidemia (HP:0002912) | 1.68253346 |
| 146 | Optic disc pallor (HP:0000543) | 1.66855159 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.06735945 |
| 2 | EIF2AK1 | 4.26422961 |
| 3 | WEE1 | 4.20553483 |
| 4 | CDC7 | 3.01224877 |
| 5 | NME2 | 2.99329845 |
| 6 | TESK2 | 2.88114768 |
| 7 | VRK2 | 2.71503721 |
| 8 | STK16 | 2.64646731 |
| 9 | EIF2AK3 | 2.56867003 |
| 10 | NEK2 | 2.35341809 |
| 11 | NEK1 | 2.34912181 |
| 12 | PLK4 | 2.31375075 |
| 13 | SRPK1 | 2.29940615 |
| 14 | ACVR1B | 2.29707364 |
| 15 | TTK | 2.22016108 |
| 16 | TSSK6 | 2.14937787 |
| 17 | DYRK3 | 1.91895914 |
| 18 | BRSK2 | 1.84929318 |
| 19 | TRIM28 | 1.84721120 |
| 20 | PLK1 | 1.83650945 |
| 21 | NUAK1 | 1.76620107 |
| 22 | EPHA2 | 1.61968983 |
| 23 | MKNK1 | 1.57349516 |
| 24 | SCYL2 | 1.57324457 |
| 25 | RPS6KA4 | 1.54622001 |
| 26 | PBK | 1.53751549 |
| 27 | VRK1 | 1.51040785 |
| 28 | AURKB | 1.50893697 |
| 29 | BCKDK | 1.48978055 |
| 30 | TAF1 | 1.46096063 |
| 31 | PLK3 | 1.43921434 |
| 32 | TESK1 | 1.41670084 |
| 33 | MAP3K8 | 1.37709318 |
| 34 | CDK7 | 1.36778412 |
| 35 | RPS6KB2 | 1.36456510 |
| 36 | PIM2 | 1.35214147 |
| 37 | TLK1 | 1.30710817 |
| 38 | AURKA | 1.29157076 |
| 39 | TAOK1 | 1.22169497 |
| 40 | ATR | 1.18089341 |
| 41 | CHEK2 | 1.14719650 |
| 42 | KDR | 1.09256388 |
| 43 | CDK4 | 1.08315143 |
| 44 | MKNK2 | 1.06871560 |
| 45 | MAP3K11 | 1.06027053 |
| 46 | MAPKAPK3 | 1.05326645 |
| 47 | MAP3K12 | 1.03171389 |
| 48 | LIMK1 | 1.01561921 |
| 49 | PASK | 1.00184601 |
| 50 | STK10 | 0.97975256 |
| 51 | CHEK1 | 0.97547341 |
| 52 | PAK4 | 0.93514709 |
| 53 | ZAK | 0.90599433 |
| 54 | BRSK1 | 0.89224253 |
| 55 | MAP4K2 | 0.84121622 |
| 56 | NME1 | 0.83344772 |
| 57 | BRAF | 0.82282203 |
| 58 | PDK3 | 0.80762427 |
| 59 | PDK4 | 0.80762427 |
| 60 | STK38L | 0.79824754 |
| 61 | STK4 | 0.79763805 |
| 62 | PAK1 | 0.74720399 |
| 63 | WNK3 | 0.73311283 |
| 64 | ALK | 0.72381021 |
| 65 | CSNK2A2 | 0.71081337 |
| 66 | LATS2 | 0.70681333 |
| 67 | TGFBR1 | 0.69042058 |
| 68 | DYRK2 | 0.67728581 |
| 69 | ABL2 | 0.65396433 |
| 70 | BMPR1B | 0.65258600 |
| 71 | CSNK2A1 | 0.64502976 |
| 72 | PIM1 | 0.64251735 |
| 73 | STK3 | 0.63992181 |
| 74 | EIF2AK2 | 0.62088277 |
| 75 | CDK2 | 0.61558115 |
| 76 | LRRK2 | 0.61537589 |
| 77 | BCR | 0.60583465 |
| 78 | MELK | 0.60573972 |
| 79 | PDK2 | 0.59244531 |
| 80 | MST4 | 0.59041826 |
| 81 | CSNK1G3 | 0.58545184 |
| 82 | MAP2K3 | 0.57563699 |
| 83 | ATM | 0.57097739 |
| 84 | FLT3 | 0.55884055 |
| 85 | CSNK1G1 | 0.55668227 |
| 86 | CLK1 | 0.52840725 |
| 87 | LATS1 | 0.52448630 |
| 88 | IRAK3 | 0.51515637 |
| 89 | CCNB1 | 0.51321879 |
| 90 | PRKCI | 0.50561867 |
| 91 | MAP3K3 | 0.49966392 |
| 92 | RPS6KA5 | 0.49452135 |
| 93 | PNCK | 0.48274988 |
| 94 | CDK6 | 0.48105745 |
| 95 | GRK1 | 0.47677895 |
| 96 | MAP3K5 | 0.45417647 |
| 97 | TAOK2 | 0.44684173 |
| 98 | CDK8 | 0.43480925 |
| 99 | DAPK1 | 0.43186927 |
| 100 | ILK | 0.42344521 |
| 101 | CSNK1A1L | 0.42321871 |
| 102 | ERBB3 | 0.42293801 |
| 103 | NEK9 | 0.42137793 |
| 104 | CDK1 | 0.41154702 |
| 105 | ADRBK2 | 0.38977062 |
| 106 | CSNK1G2 | 0.38853980 |
| 107 | JAK3 | 0.37979571 |
| 108 | DYRK1A | 0.37824832 |
| 109 | AKT2 | 0.36450125 |
| 110 | CSNK1E | 0.34074737 |
| 111 | ARAF | 0.33984790 |
| 112 | FRK | 0.31868168 |
| 113 | WNK4 | 0.31691876 |
| 114 | MAP4K1 | 0.27937346 |
| 115 | CDK12 | 0.27769379 |
| 116 | AKT3 | 0.26677867 |
| 117 | MET | 0.26590122 |
| 118 | ZAP70 | 0.25355147 |
| 119 | STK24 | 0.25078459 |
| 120 | MAPKAPK5 | 0.25009559 |
| 121 | EEF2K | 0.24921357 |
| 122 | RAF1 | 0.23201148 |
| 123 | PKN2 | 0.22639950 |
| 124 | PAK2 | 0.19803167 |
| 125 | MTOR | 0.18957638 |
| 126 | ERBB4 | 0.18757041 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.25930534 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.07714252 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.90785870 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.55415753 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.50706461 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 3.27281681 |
| 7 | RNA transport_Homo sapiens_hsa03013 | 3.06585993 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.96180054 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.69984390 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.50244392 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.49896945 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.48477916 |
| 13 | Base excision repair_Homo sapiens_hsa03410 | 2.35148149 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 2.31657793 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.20448156 |
| 16 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.74715347 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.71210438 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.56425299 |
| 19 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.55880249 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.55303302 |
| 21 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.52389396 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.47625635 |
| 23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.45457269 |
| 24 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.44843159 |
| 25 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.38226065 |
| 26 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.36055788 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.30867237 |
| 28 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.28795518 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.23194246 |
| 30 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.21053058 |
| 31 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.20413050 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.19846431 |
| 33 | Protein export_Homo sapiens_hsa03060 | 1.17686360 |
| 34 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.16413603 |
| 35 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.13259655 |
| 36 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.11423608 |
| 37 | Carbon metabolism_Homo sapiens_hsa01200 | 1.10901227 |
| 38 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.10358839 |
| 39 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.07863779 |
| 40 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.06945062 |
| 41 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.05037456 |
| 42 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.01055715 |
| 43 | Sulfur relay system_Homo sapiens_hsa04122 | 1.00803772 |
| 44 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.94224679 |
| 45 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.93133103 |
| 46 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.86707718 |
| 47 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.85903547 |
| 48 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.81248948 |
| 49 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.78425554 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.76973867 |
| 51 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.75517648 |
| 52 | Huntingtons disease_Homo sapiens_hsa05016 | 0.73937966 |
| 53 | Parkinsons disease_Homo sapiens_hsa05012 | 0.71453043 |
| 54 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.71030781 |
| 55 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.69286518 |
| 56 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.66380755 |
| 57 | Legionellosis_Homo sapiens_hsa05134 | 0.65812504 |
| 58 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.61467044 |
| 59 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.61334381 |
| 60 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.60717896 |
| 61 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.60202974 |
| 62 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.57573488 |
| 63 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.57036319 |
| 64 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.55357234 |
| 65 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.50966650 |
| 66 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.49092245 |
| 67 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.48633043 |
| 68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.48573526 |
| 69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48491728 |
| 70 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.48006315 |
| 71 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.47475242 |
| 72 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.46694049 |
| 73 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.40466468 |
| 74 | Thyroid cancer_Homo sapiens_hsa05216 | 0.40274902 |
| 75 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.39131042 |
| 76 | Phototransduction_Homo sapiens_hsa04744 | 0.38827483 |
| 77 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.37384880 |
| 78 | HTLV-I infection_Homo sapiens_hsa05166 | 0.36907575 |
| 79 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.35588279 |
| 80 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.35556078 |
| 81 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.34498907 |
| 82 | Lysine degradation_Homo sapiens_hsa00310 | 0.32360802 |
| 83 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.30824184 |
| 84 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.29365348 |
| 85 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.27698201 |
| 86 | Apoptosis_Homo sapiens_hsa04210 | 0.27405621 |
| 87 | Peroxisome_Homo sapiens_hsa04146 | 0.26611820 |
| 88 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.25895550 |
| 89 | Galactose metabolism_Homo sapiens_hsa00052 | 0.23998155 |
| 90 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.23222155 |
| 91 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.22809361 |
| 92 | Shigellosis_Homo sapiens_hsa05131 | 0.20886237 |
| 93 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.19461697 |
| 94 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.19221940 |
| 95 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.18067787 |
| 96 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.17895472 |
| 97 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.17867253 |
| 98 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.16979896 |
| 99 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.16395065 |
| 100 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.16008085 |
| 101 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.14976986 |
| 102 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.14755487 |
| 103 | Bladder cancer_Homo sapiens_hsa05219 | 0.14470664 |
| 104 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.14333251 |
| 105 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.14277528 |
| 106 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.12683408 |
| 107 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.12092023 |
| 108 | Retinol metabolism_Homo sapiens_hsa00830 | 0.11643509 |
| 109 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.11492786 |
| 110 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.10484607 |
| 111 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.09696715 |
| 112 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.08361828 |
| 113 | Alzheimers disease_Homo sapiens_hsa05010 | 0.08294870 |
| 114 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.08130284 |
| 115 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.07899551 |
| 116 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.07849336 |
| 117 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.05855892 |
| 118 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.05635768 |
| 119 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.05477251 |
| 120 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.04992039 |

