PNOC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of MHC class I biosynthetic process (GO:0045343)8.76708052
2natural killer cell activation involved in immune response (GO:0002323)8.02655199
3B cell proliferation (GO:0042100)7.24195209
4vocalization behavior (GO:0071625)7.01877228
5neuron cell-cell adhesion (GO:0007158)6.91024408
6startle response (GO:0001964)6.74224284
7regulation of penile erection (GO:0060405)6.57082793
8B cell receptor signaling pathway (GO:0050853)6.22220335
9type I interferon signaling pathway (GO:0060337)5.84960639
10cellular response to type I interferon (GO:0071357)5.84960639
11response to type I interferon (GO:0034340)5.74703199
12antigen processing and presentation of endogenous antigen (GO:0019883)5.72042476
13negative regulation of synaptic transmission, GABAergic (GO:0032229)5.68519577
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.58578777
15regulation of B cell receptor signaling pathway (GO:0050855)5.51566370
16immunoglobulin mediated immune response (GO:0016064)5.41743076
17positive regulation of humoral immune response (GO:0002922)5.27621050
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.26420562
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.25040696
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.13299810
21locomotory exploration behavior (GO:0035641)5.07366152
22regulation of glutamate receptor signaling pathway (GO:1900449)5.01172917
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.97820518
24gamma-aminobutyric acid transport (GO:0015812)4.96304869
25presynaptic membrane assembly (GO:0097105)4.96160097
26succinate metabolic process (GO:0006105)4.94154954
27regulation of short-term neuronal synaptic plasticity (GO:0048172)4.88582888
28synaptic vesicle exocytosis (GO:0016079)4.80171386
29negative regulation of catecholamine secretion (GO:0033604)4.75277993
30neurotransmitter secretion (GO:0007269)4.72179977
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.67342240
32regulation of dendritic cell antigen processing and presentation (GO:0002604)4.63903844
33postsynaptic membrane organization (GO:0001941)4.62692619
34positive regulation of synapse maturation (GO:0090129)4.57995237
35interferon-gamma-mediated signaling pathway (GO:0060333)4.50597146
36protein localization to synapse (GO:0035418)4.48655219
37presynaptic membrane organization (GO:0097090)4.44823466
38neurotransmitter-gated ion channel clustering (GO:0072578)4.40404796
39positive regulation of synapse assembly (GO:0051965)4.39070510
40gamma-aminobutyric acid signaling pathway (GO:0007214)4.35847097
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.31484865
42regulation of synapse maturation (GO:0090128)4.26548705
43B cell mediated immunity (GO:0019724)4.21260115
44neuron recognition (GO:0008038)4.20501740
45regulation of antigen processing and presentation (GO:0002577)4.19824648
46post-embryonic morphogenesis (GO:0009886)4.16310125
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11773043
48negative regulation of cell killing (GO:0031342)4.11773043
49exploration behavior (GO:0035640)4.10907872
50regulation of action potential (GO:0098900)4.09992546
51ATP hydrolysis coupled proton transport (GO:0015991)4.03229242
52energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.03229242
53B cell homeostasis (GO:0001782)4.01587474
54ionotropic glutamate receptor signaling pathway (GO:0035235)4.01342489
55negative regulation of T cell mediated immunity (GO:0002710)4.00395761
56positive regulation of gamma-delta T cell activation (GO:0046645)3.99911814
57neuron-neuron synaptic transmission (GO:0007270)3.98528524
58protein-cofactor linkage (GO:0018065)3.98014641
59lymphocyte proliferation (GO:0046651)3.96698834
60negative thymic T cell selection (GO:0045060)3.91520097
61regulation of interferon-beta biosynthetic process (GO:0045357)3.90803670
62mononuclear cell proliferation (GO:0032943)3.90096330
63regulation of synaptic transmission, GABAergic (GO:0032228)3.88010406
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87415849
65positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.81436901
66transferrin transport (GO:0033572)3.81423825
67glycine transport (GO:0015816)3.77277177
68positive regulation of antigen processing and presentation (GO:0002579)3.76609413
69negative regulation of amine transport (GO:0051953)3.76116988
70neuronal action potential propagation (GO:0019227)3.75508251
71regulation of synaptic vesicle exocytosis (GO:2000300)3.74751877
72NIK/NF-kappaB signaling (GO:0038061)3.72316537
73negative regulation of norepinephrine secretion (GO:0010700)3.70613721
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70328636
75neurotransmitter transport (GO:0006836)3.68465148
76cellular response to interferon-beta (GO:0035458)3.67229624
77positive regulation of action potential (GO:0045760)3.66718287
78response to cocaine (GO:0042220)3.66369312
79regulation of type I interferon-mediated signaling pathway (GO:0060338)3.64803186
80T cell migration (GO:0072678)3.63007254
81long-term memory (GO:0007616)3.62883394
82positive regulation of B cell differentiation (GO:0045579)3.62816608
83response to exogenous dsRNA (GO:0043330)3.59925103
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59720596
85defense response to protozoan (GO:0042832)3.56954543
86trivalent inorganic cation transport (GO:0072512)3.56904058
87ferric iron transport (GO:0015682)3.56904058
88negative T cell selection (GO:0043383)3.55838348
89regulation of B cell differentiation (GO:0045577)3.55075735
90synaptic transmission, glutamatergic (GO:0035249)3.54053630
91leukocyte proliferation (GO:0070661)3.52596982
92glutamate receptor signaling pathway (GO:0007215)3.51709198
93positive regulation of type 2 immune response (GO:0002830)3.49326307
94mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.48846265
95detection of bacterium (GO:0016045)3.47932413
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47477302
97positive regulation by organism of defense response of other organism involved in symbiotic interact3.47477302
98modulation by symbiont of host immune response (GO:0052553)3.47477302
99positive regulation by symbiont of host defense response (GO:0052509)3.47477302
100modulation by symbiont of host defense response (GO:0052031)3.47477302
101modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47477302
102axonal fasciculation (GO:0007413)3.46320855
103positive regulation of interferon-alpha production (GO:0032727)3.45408603
104positive regulation of amino acid transport (GO:0051957)3.45090647
105regulation of synapse assembly (GO:0051963)3.44582889
106aggressive behavior (GO:0002118)3.42960361
107response to histamine (GO:0034776)3.42515121
108CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.42397258
109regulation of neurotransmitter levels (GO:0001505)3.41435333
110glutamate secretion (GO:0014047)3.41168133
111detection of calcium ion (GO:0005513)3.40977801
112long-term synaptic potentiation (GO:0060291)3.39392774
113regulation of synaptic transmission, glutamatergic (GO:0051966)3.38237965
114regulation of synaptic vesicle transport (GO:1902803)3.38114896
115transmission of nerve impulse (GO:0019226)3.36738980
116regulation of interferon-gamma biosynthetic process (GO:0045072)3.36710345
117activated T cell proliferation (GO:0050798)3.34759031
118regulation of B cell proliferation (GO:0030888)3.34502091
119behavioral response to nicotine (GO:0035095)3.33869267
120positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31306210
121negative regulation of viral genome replication (GO:0045071)3.30148327
122negative regulation of type 2 immune response (GO:0002829)3.29908196
123negative regulation of lymphocyte mediated immunity (GO:0002707)3.29907921
124neurotransmitter biosynthetic process (GO:0042136)3.29810883
125positive regulation of B cell proliferation (GO:0030890)3.26376876
126T cell activation involved in immune response (GO:0002286)3.25913049
127positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25478809
128macrophage activation involved in immune response (GO:0002281)3.24809028
129synapse assembly (GO:0007416)3.24732248
130adaptive immune response (GO:0002250)3.24569066
131thymic T cell selection (GO:0045061)3.24387161
132response to protozoan (GO:0001562)3.24162255
133cellular response to exogenous dsRNA (GO:0071360)3.24158251
134positive thymic T cell selection (GO:0045059)3.23267239
135regulation of interferon-alpha production (GO:0032647)3.22426016
136regulation of type 2 immune response (GO:0002828)3.21964174
137response to interferon-beta (GO:0035456)3.21090353
138regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20195704
139learning (GO:0007612)3.19104819
140negative regulation of mast cell activation (GO:0033004)3.17419450
141female mating behavior (GO:0060180)3.13594853
142cellular response to interferon-gamma (GO:0071346)3.13396018
143detection of other organism (GO:0098543)3.13150745
144negative regulation of dendrite morphogenesis (GO:0050774)3.12820810
145dicarboxylic acid catabolic process (GO:0043649)3.09332956
146synaptic vesicle maturation (GO:0016188)3.08530140
147regulation of feeding behavior (GO:0060259)3.08396802
148righting reflex (GO:0060013)3.07010352
149cellular response to ammonium ion (GO:0071242)3.06131762
150pyrimidine nucleobase catabolic process (GO:0006208)3.05531363
151serotonin receptor signaling pathway (GO:0007210)3.05296282
152antigen receptor-mediated signaling pathway (GO:0050851)3.05077168
153auditory behavior (GO:0031223)3.04849684
154multicellular organismal reproductive behavior (GO:0033057)3.04675446
155intraspecies interaction between organisms (GO:0051703)3.03669360
156social behavior (GO:0035176)3.03669360
157positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03445100
158maternal behavior (GO:0042711)3.02681635
159response to dsRNA (GO:0043331)3.02010687
160regulation of T-helper 1 cell differentiation (GO:0045625)3.00947396
161positive regulation of membrane potential (GO:0045838)3.00903852
162natural killer cell activation (GO:0030101)3.00856286
163chaperone-mediated protein transport (GO:0072321)2.99714835
164chaperone mediated protein folding requiring cofactor (GO:0051085)2.98778141
165regulation of neuronal synaptic plasticity (GO:0048168)2.98360751
166multi-organism behavior (GO:0051705)2.98231495
167positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97621330
168cerebellar granule cell differentiation (GO:0021707)2.96499008
169proline transport (GO:0015824)2.96292970
170behavioral defense response (GO:0002209)2.96248890
171behavioral fear response (GO:0001662)2.96248890
172negative regulation of dendrite development (GO:2000171)2.95737184
173mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94272238
174layer formation in cerebral cortex (GO:0021819)2.93185080
175cerebellar Purkinje cell differentiation (GO:0021702)2.93093704
176T cell costimulation (GO:0031295)2.92656603
177regulation of excitatory postsynaptic membrane potential (GO:0060079)2.92412529
178positive regulation of protein homooligomerization (GO:0032464)2.92253536
179membrane hyperpolarization (GO:0060081)2.91610872
180positive regulation of B cell activation (GO:0050871)2.91243879
181regulation of glutamate secretion (GO:0014048)2.90386171
182dendritic spine morphogenesis (GO:0060997)2.90079745
183negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89587397
184cell morphogenesis involved in neuron differentiation (GO:0048667)2.89543365
185lymphocyte costimulation (GO:0031294)2.88340762
186B cell activation (GO:0042113)2.87441740
187lymphocyte homeostasis (GO:0002260)2.85676287
188positive regulation of granulocyte chemotaxis (GO:0071624)2.85408160
189T-helper 1 type immune response (GO:0042088)2.82615533
190positive regulation of immunoglobulin mediated immune response (GO:0002891)2.81722649
191positive regulation of B cell mediated immunity (GO:0002714)2.81722649
192T cell selection (GO:0045058)2.80359948
193positive regulation of neutrophil chemotaxis (GO:0090023)2.79178357
194positive regulation of neutrophil migration (GO:1902624)2.79178357
195negative regulation of leukocyte mediated immunity (GO:0002704)2.77898535
196negative regulation of bone resorption (GO:0045779)2.76381962
197regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.75833905
198negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.75661964
199positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)10.2958257
200regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)10.2958257

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human9.08097247
2EZH2_22144423_ChIP-Seq_EOC_Human6.82096905
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.45743270
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.53706676
5GBX2_23144817_ChIP-Seq_PC3_Human4.16638883
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.15139258
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.97937319
8MYC_22102868_ChIP-Seq_BL_Human3.53067456
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.50815462
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.27486545
11* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.17947569
12TAF15_26573619_Chip-Seq_HEK293_Human3.13549379
13CIITA_25753668_ChIP-Seq_RAJI_Human3.05553999
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98866913
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94588125
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92098319
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65906714
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.60017473
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.56473048
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51456176
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50971599
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48179531
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48125348
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47944807
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45366824
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43784792
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.42535173
28REST_21632747_ChIP-Seq_MESCs_Mouse2.39778814
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33273371
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33273371
31MYB_26560356_Chip-Seq_TH2_Human2.31345750
32* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30352168
33BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29199445
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18103547
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15868031
36* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15036431
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11090098
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11000772
39MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10666117
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09776659
41EZH2_27294783_Chip-Seq_ESCs_Mouse2.07111280
42SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06132514
43RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04268516
44CBX2_27304074_Chip-Seq_ESCs_Mouse2.02895988
45IGF1R_20145208_ChIP-Seq_DFB_Human1.95635418
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.95062368
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.94678064
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93702072
49FUS_26573619_Chip-Seq_HEK293_Human1.92508549
50MYB_26560356_Chip-Seq_TH1_Human1.90670116
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.90595627
52P300_19829295_ChIP-Seq_ESCs_Human1.90349219
53MAF_26560356_Chip-Seq_TH1_Human1.88110399
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85604618
55VDR_24763502_ChIP-Seq_THP-1_Human1.83547151
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83139054
57SPI1_23547873_ChIP-Seq_NB4_Human1.80786245
58RUNX_20019798_ChIP-Seq_JUKART_Human1.80025415
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75474421
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.75267242
61VDR_21846776_ChIP-Seq_THP-1_Human1.73748887
62RNF2_27304074_Chip-Seq_NSC_Mouse1.73195299
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71004905
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69793751
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66665881
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65478390
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62662320
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60912721
69GATA3_27048872_Chip-Seq_THYMUS_Human1.60248778
70ER_23166858_ChIP-Seq_MCF-7_Human1.57516443
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55941330
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55647751
73AR_21572438_ChIP-Seq_LNCaP_Human1.54710069
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.53296302
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53234302
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.52612735
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.51352983
78MAF_26560356_Chip-Seq_TH2_Human1.48095036
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42575073
80UTX_26944678_Chip-Seq_JUKART_Human1.41049983
81DROSHA_22980978_ChIP-Seq_HELA_Human1.40579048
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40277281
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.39551379
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.39279294
85AR_25329375_ChIP-Seq_VCAP_Human1.37895040
86* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36848980
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36695329
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35599393
89* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35156707
90SPI1_23127762_ChIP-Seq_K562_Human1.34918022
91* RARB_27405468_Chip-Seq_BRAIN_Mouse1.33938955
92SMRT_27268052_Chip-Seq_Bcells_Human1.33623948
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33340451
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.32842262
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.28528822
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25396528
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25132944
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24971813
99VDR_22108803_ChIP-Seq_LS180_Human1.24592479
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23462559
101ZNF274_21170338_ChIP-Seq_K562_Hela1.21471466
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.21345558
103JUN_21703547_ChIP-Seq_K562_Human1.21314703
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.21119225
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21065967
106* GATA3_26560356_Chip-Seq_TH2_Human1.20911824
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20538915
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19582505
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19076160
110STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19026424
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17854560
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17038482
113VDR_24787735_ChIP-Seq_THP-1_Human1.16016328
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13773984
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12446747
116RUNX2_22187159_ChIP-Seq_PCA_Human1.11822214
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11560198
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11269792
119TCF4_23295773_ChIP-Seq_U87_Human1.11128367
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11023282
121RING1B_27294783_Chip-Seq_ESCs_Mouse1.09351466
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08228807
123STAT3_23295773_ChIP-Seq_U87_Human1.08157897
124VDR_23849224_ChIP-Seq_CD4+_Human1.08041500
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06646179
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06097393
127P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05928774
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05847805
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05140404
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04525807
131PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03244112
132ARNT_22903824_ChIP-Seq_MCF-7_Human1.02835817
133EWS_26573619_Chip-Seq_HEK293_Human1.01767425
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01057785
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01057785
136SCL_19346495_ChIP-Seq_HPC-7_Human0.99293605
137P53_22387025_ChIP-Seq_ESCs_Mouse0.98806295
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97673307
139RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97288286
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96519552
141* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96173876
142CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96123578
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94793882
144SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94583824
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94466449
146AHR_22903824_ChIP-Seq_MCF-7_Human0.94031446
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93511376
148AR_19668381_ChIP-Seq_PC3_Human0.93152546
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93067987
150KDM2B_26808549_Chip-Seq_REH_Human0.93064499
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.92708718
152* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92564247
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92044061
154CMYC_18555785_Chip-Seq_ESCs_Mouse0.91873854
155SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90905898
156RING1B_27294783_Chip-Seq_NPCs_Mouse0.90821685
157PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88279459
158BP1_19119308_ChIP-ChIP_Hs578T_Human0.85367440
159ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84412711
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84212257
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80516486
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79764381
163GATA3_26560356_Chip-Seq_TH1_Human0.79737057
164VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76087367
165KDM2B_26808549_Chip-Seq_DND41_Human0.74945898
166MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74847451
167SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.74398088
168GATA1_19941827_ChIP-Seq_MEL_Mouse0.72344254
169SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72320044
170TCF7_22412390_ChIP-Seq_EML_Mouse0.70864366
171P300_27268052_Chip-Seq_Bcells_Human0.69313658
172DNAJC2_21179169_ChIP-ChIP_NT2_Human0.68480617
173SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67318121
174PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65588358
175EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.65120375
176* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65058124
177ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.64388891
178TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.64372395
179NFE2_27457419_Chip-Seq_LIVER_Mouse0.64349895
180* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.63646778
181BRD4_27068464_Chip-Seq_AML-cells_Mouse0.62955097
182TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.62500835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.82752603
2MP0002822_catalepsy4.57048160
3MP0004859_abnormal_synaptic_plasticity4.06591031
4MP0001800_abnormal_humoral_immune3.97292787
5MP0005387_immune_system_phenotype3.92833650
6MP0001790_abnormal_immune_system3.92833650
7MP0002138_abnormal_hepatobiliary_system3.76495676
8MP0005671_abnormal_response_to3.69659086
9MP0003880_abnormal_central_pattern3.62897350
10MP0003303_peritoneal_inflammation3.58776893
11MP0003635_abnormal_synaptic_transmissio3.48453174
12MP0009046_muscle_twitch3.40695185
13MP0000685_abnormal_immune_system3.36295805
14MP0002735_abnormal_chemical_nociception3.23455543
15* MP0009745_abnormal_behavioral_response3.19037269
16MP0002064_seizures3.10721266
17MP0005000_abnormal_immune_tolerance3.01638527
18MP0001188_hyperpigmentation2.96869948
19MP0002452_abnormal_antigen_presenting2.88146007
20MP0005423_abnormal_somatic_nervous2.86935025
21MP0002063_abnormal_learning/memory/cond2.86314863
22MP0002723_abnormal_immune_serum2.76311315
23MP0002572_abnormal_emotion/affect_behav2.69656143
24MP0009785_altered_susceptibility_to2.63293719
25MP0002420_abnormal_adaptive_immunity2.59775681
26MP0003724_increased_susceptibility_to2.55766578
27MP0001819_abnormal_immune_cell2.53115692
28MP0001968_abnormal_touch/_nociception2.52364414
29MP0001486_abnormal_startle_reflex2.44170554
30MP0002272_abnormal_nervous_system2.42457726
31MP0005646_abnormal_pituitary_gland2.41243910
32MP0003122_maternal_imprinting2.40737595
33MP0001348_abnormal_lacrimal_gland2.30552986
34MP0001529_abnormal_vocalization2.28078059
35MP0005025_abnormal_response_to2.26590999
36MP0006276_abnormal_autonomic_nervous2.26583199
37MP0002398_abnormal_bone_marrow2.24811221
38MP0002736_abnormal_nociception_after2.19622415
39MP0001986_abnormal_taste_sensitivity2.15500096
40MP0000716_abnormal_immune_system2.12236250
41MP0003787_abnormal_imprinting2.10721911
42MP0010386_abnormal_urinary_bladder2.09985912
43MP0001984_abnormal_olfaction2.00090238
44MP0002184_abnormal_innervation1.95707785
45MP0001501_abnormal_sleep_pattern1.94577931
46MP0002419_abnormal_innate_immunity1.90656929
47MP0001970_abnormal_pain_threshold1.89295298
48MP0002067_abnormal_sensory_capabilities1.88243739
49MP0005310_abnormal_salivary_gland1.88093430
50MP0002557_abnormal_social/conspecific_i1.85147415
51MP0002148_abnormal_hypersensitivity_rea1.84645700
52MP0000689_abnormal_spleen_morphology1.83833167
53MP0000778_abnormal_nervous_system1.81469892
54* MP0002734_abnormal_mechanical_nocicepti1.81097700
55MP0002837_dystrophic_cardiac_calcinosis1.80288849
56MP0002876_abnormal_thyroid_physiology1.80268104
57MP0003763_abnormal_thymus_physiology1.79343491
58MP0002733_abnormal_thermal_nociception1.78634714
59MP0004270_analgesia1.72313548
60MP0001873_stomach_inflammation1.67873683
61MP0003436_decreased_susceptibility_to1.67205764
62MP0009780_abnormal_chondrocyte_physiolo1.66266429
63MP0004142_abnormal_muscle_tone1.63845614
64MP0002429_abnormal_blood_cell1.62439421
65MP0001440_abnormal_grooming_behavior1.61164693
66MP0005386_behavior/neurological_phenoty1.60379141
67MP0004924_abnormal_behavior1.60379141
68MP0002638_abnormal_pupillary_reflex1.60058431
69MP0006082_CNS_inflammation1.58652881
70MP0005645_abnormal_hypothalamus_physiol1.58013826
71MP0002722_abnormal_immune_system1.49456825
72MP0001845_abnormal_inflammatory_respons1.46573550
73MP0000013_abnormal_adipose_tissue1.45971604
74MP0008569_lethality_at_weaning1.38773510
75MP0005464_abnormal_platelet_physiology1.38284549
76MP0004811_abnormal_neuron_physiology1.37444980
77MP0001905_abnormal_dopamine_level1.30998446
78MP0003646_muscle_fatigue1.30894985
79MP0002166_altered_tumor_susceptibility1.28355368
80MP0003329_amyloid_beta_deposits1.27916713
81MP0002066_abnormal_motor_capabilities/c1.27679053
82MP0002882_abnormal_neuron_morphology1.27072361
83MP0003121_genomic_imprinting1.26760020
84MP0000703_abnormal_thymus_morphology1.25527940
85MP0000955_abnormal_spinal_cord1.23239701
86MP0000465_gastrointestinal_hemorrhage1.21272293
87MP0003879_abnormal_hair_cell1.20490649
88MP0006292_abnormal_olfactory_placode1.17700579
89MP0003045_fibrosis1.17243253
90MP0004885_abnormal_endolymph1.16234140
91MP0005084_abnormal_gallbladder_morpholo1.15862008
92MP0002102_abnormal_ear_morphology1.14554385
93MP0000569_abnormal_digit_pigmentation1.14159050
94MP0008469_abnormal_protein_level1.10631544
95MP0000015_abnormal_ear_pigmentation1.10218821
96MP0008877_abnormal_DNA_methylation1.08723433
97MP0010155_abnormal_intestine_physiology1.07856343
98MP0001963_abnormal_hearing_physiology1.07362067
99MP0001502_abnormal_circadian_rhythm1.05457071
100MP0002405_respiratory_system_inflammati1.03329494
101MP0004742_abnormal_vestibular_system1.00333904
102MP0001177_atelectasis0.99612965
103MP0002152_abnormal_brain_morphology0.99530507
104MP0000026_abnormal_inner_ear0.98560953
105MP0003718_maternal_effect0.97229479
106MP0001270_distended_abdomen0.96728550
107MP0003123_paternal_imprinting0.95883995
108MP0001663_abnormal_digestive_system0.95123928
109MP0005551_abnormal_eye_electrophysiolog0.95030827
110MP0002069_abnormal_eating/drinking_beha0.94374287
111MP0005670_abnormal_white_adipose0.93247972
112MP0003866_abnormal_defecation0.93030869
113MP0003938_abnormal_ear_development0.92872165
114MP0000604_amyloidosis0.91628456
115MP0001664_abnormal_digestion0.90008895
116MP0009333_abnormal_splenocyte_physiolog0.88912656
117MP0000538_abnormal_urinary_bladder0.88819439
118MP0002752_abnormal_somatic_nervous0.88440214
119MP0000631_abnormal_neuroendocrine_gland0.88408591
120MP0002928_abnormal_bile_duct0.87726321
121MP0005499_abnormal_olfactory_system0.86913521
122MP0005394_taste/olfaction_phenotype0.86913521
123MP0005171_absent_coat_pigmentation0.86660462
124MP0002909_abnormal_adrenal_gland0.85410243
125MP0004085_abnormal_heartbeat0.83034757
126MP0008874_decreased_physiological_sensi0.82976678
127MP0002653_abnormal_ependyma_morphology0.81731788
128MP0000613_abnormal_salivary_gland0.81612501
129MP0006035_abnormal_mitochondrial_morpho0.77826927
130MP0005379_endocrine/exocrine_gland_phen0.77694349
131MP0002229_neurodegeneration0.77073667
132MP0003632_abnormal_nervous_system0.76355574
133MP0002693_abnormal_pancreas_physiology0.75452994
134MP0004215_abnormal_myocardial_fiber0.74926047
135MP0002139_abnormal_hepatobiliary_system0.74018586
136MP0000751_myopathy0.73495510
137MP0000566_synostosis0.71514722
138MP0002006_tumorigenesis0.71220285
139MP0002277_abnormal_respiratory_mucosa0.70334192
140MP0003631_nervous_system_phenotype0.69849159
141MP0004510_myositis0.69662903
142MP0003300_gastrointestinal_ulcer0.69261268
143MP0005253_abnormal_eye_physiology0.68356819
144MP0003385_abnormal_body_wall0.68327992
145MP0001943_abnormal_respiration0.67557392
146MP0006072_abnormal_retinal_apoptosis0.67542794
147MP0003137_abnormal_impulse_conducting0.65882023
148MP0002090_abnormal_vision0.65448624
149MP0002136_abnormal_kidney_physiology0.64149743
150MP0008872_abnormal_physiological_respon0.63562599
151MP0002095_abnormal_skin_pigmentation0.63465402
152MP0008260_abnormal_autophagy0.63110106
153MP0000371_diluted_coat_color0.62177622
154MP0008789_abnormal_olfactory_epithelium0.62050676
155MP0001346_abnormal_lacrimal_gland0.62022581
156MP0000537_abnormal_urethra_morphology0.61197270
157MP0003183_abnormal_peptide_metabolism0.61064331
158MP0006036_abnormal_mitochondrial_physio0.60182286
159MP0010770_preweaning_lethality0.60030116
160MP0002082_postnatal_lethality0.60030116
161MP0002163_abnormal_gland_morphology0.59661218
162MP0003221_abnormal_cardiomyocyte_apopto0.59084912
163MP0000681_abnormal_thyroid_gland0.58983634
164MP0004858_abnormal_nervous_system0.58065378
165MP0003633_abnormal_nervous_system0.57817030
166MP0000767_abnormal_smooth_muscle0.55469871
167MP0005584_abnormal_enzyme/coenzyme_acti0.55299902
168MP0003091_abnormal_cell_migration0.51253672
169MP0001533_abnormal_skeleton_physiology0.48967643
170MP0004947_skin_inflammation0.48061881
171MP0000372_irregular_coat_pigmentation0.46801481

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)8.15957733
2Focal motor seizures (HP:0011153)7.92214657
3Gastrointestinal stroma tumor (HP:0100723)7.90688439
4Hyperventilation (HP:0002883)6.43117864
5Febrile seizures (HP:0002373)6.10944343
6Atonic seizures (HP:0010819)5.93029207
7Epileptic encephalopathy (HP:0200134)5.39070674
8Recurrent bronchitis (HP:0002837)5.26294622
9Recurrent sinusitis (HP:0011108)5.16852415
10Meningitis (HP:0001287)4.92052095
11Cellulitis (HP:0100658)4.67813155
12Focal seizures (HP:0007359)4.66753281
13Progressive inability to walk (HP:0002505)4.54279850
14Lymphopenia (HP:0001888)4.51295457
15Vasculitis (HP:0002633)4.47742223
16Absence seizures (HP:0002121)4.24460193
17Emphysema (HP:0002097)4.19770818
18Abnormality of cells of the lymphoid lineage (HP:0012140)4.16299125
19Congenital stationary night blindness (HP:0007642)4.13708804
20Papilloma (HP:0012740)4.04196147
21Verrucae (HP:0200043)4.04196147
22Panhypogammaglobulinemia (HP:0003139)4.00788287
23Chronic sinusitis (HP:0011109)3.89324441
24Dialeptic seizures (HP:0011146)3.86626050
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.85818693
26Polyphagia (HP:0002591)3.72653192
27Mediastinal lymphadenopathy (HP:0100721)3.68347179
28Recurrent pneumonia (HP:0006532)3.68318185
29Colitis (HP:0002583)3.67951246
30IgM deficiency (HP:0002850)3.66669722
31Acute necrotizing encephalopathy (HP:0006965)3.64190156
32Recurrent viral infections (HP:0004429)3.60138889
33Abnormal hair whorl (HP:0010721)3.56904710
34Osteomyelitis (HP:0002754)3.54746728
35Generalized tonic-clonic seizures (HP:0002069)3.52817656
36Broad-based gait (HP:0002136)3.52589078
37Inflammation of the large intestine (HP:0002037)3.45987939
38Recurrent cutaneous fungal infections (HP:0011370)3.42238400
39Chronic mucocutaneous candidiasis (HP:0002728)3.42238400
40Abnormal mitochondria in muscle tissue (HP:0008316)3.40331122
41Inability to walk (HP:0002540)3.37925800
42Gastrointestinal inflammation (HP:0004386)3.35490037
43Protruding tongue (HP:0010808)3.32849659
44Restrictive lung disease (HP:0002091)3.32825695
45Abnormality of the prostate (HP:0008775)3.30259960
46Progressive macrocephaly (HP:0004481)3.29978403
47Myokymia (HP:0002411)3.29305593
48Recurrent lower respiratory tract infections (HP:0002783)3.27113440
49Chronic otitis media (HP:0000389)3.25984591
50Gingival bleeding (HP:0000225)3.17434378
51Skin rash (HP:0000988)3.14425612
52Recurrent bacterial skin infections (HP:0005406)3.09144097
53Failure to thrive in infancy (HP:0001531)3.08791139
54IgG deficiency (HP:0004315)3.03639386
55Visual hallucinations (HP:0002367)3.03013927
56Eczematoid dermatitis (HP:0000976)3.02150269
57Poor suck (HP:0002033)3.01158505
58Spontaneous abortion (HP:0005268)3.00422601
59Gait imbalance (HP:0002141)2.98978610
60Drooling (HP:0002307)2.96360838
61Excessive salivation (HP:0003781)2.96360838
62Absent speech (HP:0001344)2.95452314
63IgA deficiency (HP:0002720)2.95334918
64Hyperthyroidism (HP:0000836)2.94457935
65Progressive cerebellar ataxia (HP:0002073)2.93129449
66Sepsis (HP:0100806)2.91583706
67Recurrent fungal infections (HP:0002841)2.89780129
68Limb dystonia (HP:0002451)2.84939548
69Medial flaring of the eyebrow (HP:0010747)2.84221805
70Narrow nasal bridge (HP:0000446)2.79827253
71Urticaria (HP:0001025)2.78401113
72Mitochondrial inheritance (HP:0001427)2.78016313
73Bronchitis (HP:0012387)2.75067857
74Chronic obstructive pulmonary disease (HP:0006510)2.73175700
75Obstructive lung disease (HP:0006536)2.73175700
76Abnormal social behavior (HP:0012433)2.71401297
77Impaired social interactions (HP:0000735)2.71401297
78Acute encephalopathy (HP:0006846)2.71091013
79Recurrent abscess formation (HP:0002722)2.70201065
80Basal cell carcinoma (HP:0002671)2.66676057
81Epileptiform EEG discharges (HP:0011182)2.66082630
82Neuroendocrine neoplasm (HP:0100634)2.64166921
83Recurrent otitis media (HP:0000403)2.61996788
84Pheochromocytoma (HP:0002666)2.61798137
85Abnormality of T cell physiology (HP:0011840)2.61455208
86Congenital primary aphakia (HP:0007707)2.61216331
87Abnormal eating behavior (HP:0100738)2.60657441
88EEG with generalized epileptiform discharges (HP:0011198)2.59654691
89Abnormality of macrophages (HP:0004311)2.58266967
90Esotropia (HP:0000565)2.57436373
91Recurrent skin infections (HP:0001581)2.56127733
92Encephalitis (HP:0002383)2.52914646
93Hypsarrhythmia (HP:0002521)2.52559250
94Poor eye contact (HP:0000817)2.51397504
95Leukopenia (HP:0001882)2.47822972
96Pulmonary infiltrates (HP:0002113)2.47543016
97Lymphoma (HP:0002665)2.46856191
98Short tibia (HP:0005736)2.46584001
99Abnormality of the labia minora (HP:0012880)2.45481660
100B lymphocytopenia (HP:0010976)2.44964052
101Abnormality of B cell number (HP:0010975)2.43079227
102Nephrogenic diabetes insipidus (HP:0009806)2.42824850
103Abnormality of male internal genitalia (HP:0000022)2.41142892
104Blue irides (HP:0000635)2.41112293
105Joint swelling (HP:0001386)2.40672695
106Sleep apnea (HP:0010535)2.34451419
107Thickened helices (HP:0000391)2.33149039
108Recurrent gram-negative bacterial infections (HP:0005420)2.33008660
109Increased CSF lactate (HP:0002490)2.32520789
110Aplasia/Hypoplasia of the tibia (HP:0005772)2.28849564
111Optic disc pallor (HP:0000543)2.28768661
112Neutropenia (HP:0001875)2.28211291
113Oligomenorrhea (HP:0000876)2.27114424
114Premature loss of primary teeth (HP:0006323)2.24182028
115Specific learning disability (HP:0001328)2.21549184
116Mutism (HP:0002300)2.20878034
117Viral hepatitis (HP:0006562)2.20705347
118Anxiety (HP:0000739)2.20111736
119Retinal dysplasia (HP:0007973)2.16570245
120Fetal akinesia sequence (HP:0001989)2.15401755
121Abnormality of salivation (HP:0100755)2.14338482
122Spastic tetraplegia (HP:0002510)2.12945747
123Truncal ataxia (HP:0002078)2.12437258
124Split foot (HP:0001839)2.12157757
125Dysdiadochokinesis (HP:0002075)2.11558623
126Genital tract atresia (HP:0001827)2.11228905
127Growth hormone deficiency (HP:0000824)2.10791656
128Amblyopia (HP:0000646)2.08399082
129Increased IgE level (HP:0003212)2.08010627
130Vaginal atresia (HP:0000148)2.07542416
131Abnormality of T cells (HP:0002843)2.07441150
132Epistaxis (HP:0000421)2.07389011
133Chronic diarrhea (HP:0002028)2.03704480
134Calf muscle hypertrophy (HP:0008981)2.00727126
135Fair hair (HP:0002286)1.98101070
136Neoplasm of the peripheral nervous system (HP:0100007)1.97895605
137Stomatitis (HP:0010280)1.96472756
138Gaze-evoked nystagmus (HP:0000640)1.95576501
139Retrobulbar optic neuritis (HP:0100654)1.94634062
140Optic neuritis (HP:0100653)1.94634062
141Chronic hepatic failure (HP:0100626)1.94493415
142Hepatocellular necrosis (HP:0001404)1.94347856
143Synostosis involving the elbow (HP:0003938)1.94152163
144Humeroradial synostosis (HP:0003041)1.94152163
145Aplasia/Hypoplasia of the lens (HP:0008063)1.93513575
146Abnormality of binocular vision (HP:0011514)1.93467579
147Diplopia (HP:0000651)1.93467579
148Agitation (HP:0000713)1.92427009
149Lissencephaly (HP:0001339)1.91787025
150Delayed gross motor development (HP:0002194)1.89665505
151Generalized myoclonic seizures (HP:0002123)1.88336843
152Akinesia (HP:0002304)1.88199586
153Skin ulcer (HP:0200042)1.86439965
154Chest pain (HP:0100749)1.85810181
155Arthralgia (HP:0002829)1.82567016
156Hypothermia (HP:0002045)1.82343976
157Abnormal pancreas size (HP:0012094)1.81897616
158Xerostomia (HP:0000217)1.80800988
159X-linked dominant inheritance (HP:0001423)1.79822755
160Gastrointestinal infarctions (HP:0005244)1.79584611
161Generalized hypopigmentation of hair (HP:0011358)1.78967789
162Bradykinesia (HP:0002067)1.78395017
163Supranuclear gaze palsy (HP:0000605)1.77510166
164Status epilepticus (HP:0002133)1.77289872
165Severe visual impairment (HP:0001141)1.76329709
166Hemiparesis (HP:0001269)1.76309383
167Shoulder girdle muscle weakness (HP:0003547)1.76048442
168Fibular hypoplasia (HP:0003038)1.75701624
169Elevated hepatic transaminases (HP:0002910)1.74736018
170Leukodystrophy (HP:0002415)1.73998494
171Spastic tetraparesis (HP:0001285)1.73191928
172Psychosis (HP:0000709)1.70370890
173Exocrine pancreatic insufficiency (HP:0001738)1.69991113
174Poor coordination (HP:0002370)1.69842952
175Complete atrioventricular canal defect (HP:0001674)1.69339146
176Muscle hypertrophy of the lower extremities (HP:0008968)1.69214467
177Depression (HP:0000716)1.69074131
178Hypergammaglobulinemia (HP:0010702)1.68808071
179Widely spaced teeth (HP:0000687)1.68410063
180Type II lissencephaly (HP:0007260)1.68377135
181Postural instability (HP:0002172)1.68267146
182Abnormality of the pleura (HP:0002103)1.67413596
183Thrombophlebitis (HP:0004418)1.66195426
184Memory impairment (HP:0002354)1.65553317
185Gastroesophageal reflux (HP:0002020)1.65264105
186Dry hair (HP:0011359)1.64415490
187Atrioventricular canal defect (HP:0006695)1.64128501
188Conical tooth (HP:0000698)1.63635088
189Petechiae (HP:0000967)1.62986226
190Poikiloderma (HP:0001029)1.62908156
191Persistence of primary teeth (HP:0006335)1.60223115
192Glucose intolerance (HP:0000833)1.60208905
193Acute hepatic failure (HP:0006554)1.57747280
194Nasal polyposis (HP:0100582)1.56632095
195Abnormality of the common coagulation pathway (HP:0010990)1.56023440
196Increased IgM level (HP:0003496)1.53138547
197Prostate neoplasm (HP:0100787)1.52096555
198Erythema (HP:0010783)1.51647863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.73996296
2TESK24.82540830
3MAP4K14.48262671
4NTRK33.72973330
5MARK13.53986408
6MAP2K73.33238442
7GRK13.31634024
8MAP3K123.23371467
9CDK192.95100036
10MAP3K42.88138455
11ERBB42.82188308
12AKT32.65169663
13NTRK22.38889222
14IRAK42.31722333
15SYK2.25197168
16BLK2.19294440
17PNCK2.11544209
18MAP3K132.10778461
19TYK22.10479543
20EIF2AK32.06662064
21IKBKE2.02744848
22MINK11.90932485
23TSSK61.89479961
24PLK21.85067944
25EPHA41.84044289
26MAP3K101.83233554
27BTK1.81978058
28SIK31.75957947
29MAP2K41.75955788
30TNIK1.67506454
31MAP3K91.61486938
32MAPK131.53994495
33TBK11.53676084
34PRPF4B1.51432499
35ARAF1.47691478
36CDK81.42237558
37TAOK31.41971655
38CSF1R1.36381853
39MUSK1.34733662
40LYN1.33262130
41MAP3K141.31446764
42SIK21.30596344
43CCNB11.25009125
44PRKCG1.22387430
45PKN11.21666383
46JAK11.20579904
47STK161.19747610
48JAK31.19512772
49IKBKB1.19432254
50PRKCE1.18798042
51GRK51.17760657
52NME11.17477311
53BCR1.13730306
54PHKG11.13726794
55PHKG21.13726794
56FES1.11956187
57MAPK111.11058341
58TEC1.10766267
59PDK31.10166229
60PDK41.10166229
61YES11.09011767
62HCK1.08421523
63CDK51.08078807
64PIK3CG1.04837322
65FGFR41.01830010
66KSR21.01431845
67TLK11.01417479
68UHMK11.01233129
69WNK31.00271257
70BMPR1B1.00253902
71GRK60.99812927
72ERBB30.99690238
73ADRBK20.98632870
74ITK0.96471237
75CAMK2A0.96028032
76PRKCQ0.93905762
77ERN10.93859280
78BRAF0.90116466
79SGK2230.89482613
80SGK4940.89482613
81DYRK20.88529179
82MARK30.87353505
83DYRK1A0.86001930
84PAK60.84811247
85BMPR20.84333642
86SGK20.83695065
87KSR10.82815504
88MATK0.77006049
89PDK10.76407918
90CAMK2B0.74613538
91DAPK10.72536344
92LCK0.72060702
93MAPK70.70921113
94IRAK20.69654719
95CSK0.69108444
96JAK20.68059828
97NEK90.66462255
98GRK70.66224052
99MKNK20.65694942
100CSNK1G20.64691446
101PDK20.60005821
102CDK140.57970708
103MARK20.57601857
104CDK180.57552976
105CDC42BPA0.57275911
106CAMK2D0.56388175
107MYLK0.55608337
108CAMKK10.55148671
109CSNK1G30.54125834
110EPHA30.52755280
111TNK20.52740955
112CAMK2G0.50306763
113PRKACA0.50139205
114SIK10.50116896
115CDK150.49354402
116ROCK20.48463393
117NTRK10.48414691
118ADRBK10.48111706
119MAPK120.46943055
120CAMK10.46812235
121PDPK10.46700525
122RAF10.46106200
123OXSR10.45891340
124SGK10.44682221
125ACVR1B0.43628740
126MAPK40.43268671
127PINK10.43175838
128TXK0.43033657
129CSNK1A1L0.42824213
130PRKCB0.42072301
131CDK30.41618881
132NEK60.41568390
133MAP3K60.40849974
134PASK0.40076045
135PRKCZ0.39353614
136PLK30.39197064
137LIMK10.38606787
138CDK11A0.38479676
139LATS20.36932105
140FGFR30.36545786
141TAOK10.36483270
142MST40.35086914
143FGR0.34907554
144MAP3K10.34213574
145RPS6KB10.33913395
146RIPK40.33779312
147MKNK10.33760070
148PRKG10.33502949
149CSNK1A10.32416963
150IRAK10.32304604
151RPS6KA50.31790004
152VRK10.31538807
153PRKCA0.31450554
154ICK0.31392053
155PIM10.31179683
156ROCK10.30707412
157FYN0.30152194
158KIT0.30144395
159CDK40.27843092
160CHUK0.27067574
161PRKCD0.26717316
162CAMKK20.26638854
163ABL10.25186300
164PRKCH0.24349928
165CDK90.22411775
166HIPK20.22247142
167EIF2AK20.21866911
168BRD40.21728986

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.81312538
2Nicotine addiction_Homo sapiens_hsa050334.67467765
3Intestinal immune network for IgA production_Homo sapiens_hsa046724.63321041
4Allograft rejection_Homo sapiens_hsa053304.38494762
5Asthma_Homo sapiens_hsa053104.09576901
6Graft-versus-host disease_Homo sapiens_hsa053323.94161031
7Synaptic vesicle cycle_Homo sapiens_hsa047213.82431765
8Primary immunodeficiency_Homo sapiens_hsa053403.72285730
9Collecting duct acid secretion_Homo sapiens_hsa049663.62952115
10GABAergic synapse_Homo sapiens_hsa047273.20756916
11B cell receptor signaling pathway_Homo sapiens_hsa046623.07242333
12Oxidative phosphorylation_Homo sapiens_hsa001903.03750296
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88349257
14Viral myocarditis_Homo sapiens_hsa054162.77060574
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60958819
16Morphine addiction_Homo sapiens_hsa050322.48192845
17Antigen processing and presentation_Homo sapiens_hsa046122.45318795
18Type I diabetes mellitus_Homo sapiens_hsa049402.34416982
19Leishmaniasis_Homo sapiens_hsa051402.31880521
20Vibrio cholerae infection_Homo sapiens_hsa051102.31538561
21Staphylococcus aureus infection_Homo sapiens_hsa051502.24185753
22Systemic lupus erythematosus_Homo sapiens_hsa053222.15892775
23Taste transduction_Homo sapiens_hsa047422.11469333
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09774681
25Parkinsons disease_Homo sapiens_hsa050122.01110265
26Long-term depression_Homo sapiens_hsa047301.98478980
27Serotonergic synapse_Homo sapiens_hsa047261.96289931
28Olfactory transduction_Homo sapiens_hsa047401.96188947
29Butanoate metabolism_Homo sapiens_hsa006501.95246918
30Circadian entrainment_Homo sapiens_hsa047131.92444668
31Glutamatergic synapse_Homo sapiens_hsa047241.91542223
32Herpes simplex infection_Homo sapiens_hsa051681.86659976
33Influenza A_Homo sapiens_hsa051641.85793227
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83043339
35Alzheimers disease_Homo sapiens_hsa050101.76296103
36Long-term potentiation_Homo sapiens_hsa047201.63882163
37Dopaminergic synapse_Homo sapiens_hsa047281.61705081
38Cardiac muscle contraction_Homo sapiens_hsa042601.61017112
39Tuberculosis_Homo sapiens_hsa051521.54630050
40Measles_Homo sapiens_hsa051621.49204494
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48723866
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47874235
43Amphetamine addiction_Homo sapiens_hsa050311.45927039
44Huntingtons disease_Homo sapiens_hsa050161.45742311
45Toxoplasmosis_Homo sapiens_hsa051451.41092510
46Insulin secretion_Homo sapiens_hsa049111.39683212
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.37287282
48Hematopoietic cell lineage_Homo sapiens_hsa046401.36931334
49Salivary secretion_Homo sapiens_hsa049701.33998206
50Cholinergic synapse_Homo sapiens_hsa047251.31896937
51Osteoclast differentiation_Homo sapiens_hsa043801.31547097
52Rheumatoid arthritis_Homo sapiens_hsa053231.31304061
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30351220
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28167720
55Calcium signaling pathway_Homo sapiens_hsa040201.23414537
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23244131
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15465573
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14503334
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13088580
60Phagosome_Homo sapiens_hsa041451.06157918
61Gastric acid secretion_Homo sapiens_hsa049711.05311541
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04323305
63Hepatitis C_Homo sapiens_hsa051601.04247762
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04192012
65Primary bile acid biosynthesis_Homo sapiens_hsa001201.03857306
66Axon guidance_Homo sapiens_hsa043601.02559003
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01658965
68Phototransduction_Homo sapiens_hsa047441.00156017
69Cocaine addiction_Homo sapiens_hsa050300.98752876
70Renin secretion_Homo sapiens_hsa049240.98232138
71Epstein-Barr virus infection_Homo sapiens_hsa051690.97826679
72Oxytocin signaling pathway_Homo sapiens_hsa049210.95216658
73Chemokine signaling pathway_Homo sapiens_hsa040620.93134978
74Hepatitis B_Homo sapiens_hsa051610.92061677
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90083878
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90009278
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.89048273
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88132931
79beta-Alanine metabolism_Homo sapiens_hsa004100.82107224
80T cell receptor signaling pathway_Homo sapiens_hsa046600.81286285
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79293265
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79062325
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75677138
84Viral carcinogenesis_Homo sapiens_hsa052030.74513628
85Gap junction_Homo sapiens_hsa045400.71919124
86Dilated cardiomyopathy_Homo sapiens_hsa054140.68157392
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67064553
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67033866
89Melanogenesis_Homo sapiens_hsa049160.66430557
90cAMP signaling pathway_Homo sapiens_hsa040240.61163049
91GnRH signaling pathway_Homo sapiens_hsa049120.59946094
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59844115
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59357682
94ErbB signaling pathway_Homo sapiens_hsa040120.57023309
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55976725
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.54765771
97Apoptosis_Homo sapiens_hsa042100.50532716
98Estrogen signaling pathway_Homo sapiens_hsa049150.49419271
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49013367
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48737395
101Ovarian steroidogenesis_Homo sapiens_hsa049130.47919802
102Alcoholism_Homo sapiens_hsa050340.47816803
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46549642
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46412617
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44933875
106Melanoma_Homo sapiens_hsa052180.44018441
107Glioma_Homo sapiens_hsa052140.43844751
108MAPK signaling pathway_Homo sapiens_hsa040100.43254845
109HTLV-I infection_Homo sapiens_hsa051660.42986461
110Fatty acid elongation_Homo sapiens_hsa000620.37656817
111Ras signaling pathway_Homo sapiens_hsa040140.37597042
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36502090
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35898997
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35378348
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34765591
116Type II diabetes mellitus_Homo sapiens_hsa049300.33923716
117Acute myeloid leukemia_Homo sapiens_hsa052210.32448455
118Oocyte meiosis_Homo sapiens_hsa041140.31400048
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25925012
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.25844808
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25632593
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24966213
123Pentose phosphate pathway_Homo sapiens_hsa000300.24953908
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.24766425
125Pancreatic secretion_Homo sapiens_hsa049720.23542290
126Thyroid hormone synthesis_Homo sapiens_hsa049180.23092095
127Rap1 signaling pathway_Homo sapiens_hsa040150.23044177
128Pyruvate metabolism_Homo sapiens_hsa006200.22803469
129Legionellosis_Homo sapiens_hsa051340.21777943
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21579556
131Ether lipid metabolism_Homo sapiens_hsa005650.21205134
132Platelet activation_Homo sapiens_hsa046110.21173184
133Autoimmune thyroid disease_Homo sapiens_hsa053200.20954460
134TNF signaling pathway_Homo sapiens_hsa046680.19956956
135Glucagon signaling pathway_Homo sapiens_hsa049220.19889295
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19856834
137Prolactin signaling pathway_Homo sapiens_hsa049170.19405606
138Regulation of autophagy_Homo sapiens_hsa041400.18739981
139Renal cell carcinoma_Homo sapiens_hsa052110.17282245
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17145776
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.15778469
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14770533
143Wnt signaling pathway_Homo sapiens_hsa043100.14766940
144Proteasome_Homo sapiens_hsa030500.13650618
145Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.13498357
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.12884234
147African trypanosomiasis_Homo sapiens_hsa051430.12783660
148Endocytosis_Homo sapiens_hsa041440.12353498
149Choline metabolism in cancer_Homo sapiens_hsa052310.11452520
150Shigellosis_Homo sapiens_hsa051310.10509037
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10441905
152Protein export_Homo sapiens_hsa030600.08825496
153Metabolic pathways_Homo sapiens_hsa011000.08819936
154Prion diseases_Homo sapiens_hsa050200.08641865
155Inositol phosphate metabolism_Homo sapiens_hsa005620.08298672
156NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06833357
157Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.06692564
158Dorso-ventral axis formation_Homo sapiens_hsa043200.06309822
159Colorectal cancer_Homo sapiens_hsa052100.06081813

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