PNP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80099775
2positive regulation of interferon-alpha production (GO:0032727)4.48506851
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26479778
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26479778
5positive regulation by symbiont of host defense response (GO:0052509)4.22914765
6modulation by symbiont of host defense response (GO:0052031)4.22914765
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.22914765
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.22914765
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.22914765
10modulation by symbiont of host immune response (GO:0052553)4.22914765
11regulation of interferon-alpha production (GO:0032647)4.21580673
12cellular response to arsenic-containing substance (GO:0071243)4.01741262
13immunoglobulin mediated immune response (GO:0016064)4.00790418
14regulation of vitamin D biosynthetic process (GO:0060556)3.90954833
15antigen processing and presentation of endogenous antigen (GO:0019883)3.87170370
16response to peptidoglycan (GO:0032494)3.81943100
17response to interferon-alpha (GO:0035455)3.79186538
18response to interferon-beta (GO:0035456)3.75134337
19type I interferon signaling pathway (GO:0060337)3.74836406
20cellular response to type I interferon (GO:0071357)3.74836406
21response to type I interferon (GO:0034340)3.72658516
22neutrophil activation involved in immune response (GO:0002283)3.70382282
23regulation of interferon-beta biosynthetic process (GO:0045357)3.57895969
24B cell mediated immunity (GO:0019724)3.43444521
25respiratory burst (GO:0045730)3.39172049
26cellular response to interferon-beta (GO:0035458)3.34845394
27positive regulation of interferon-beta production (GO:0032728)3.29040270
28negative regulation of viral genome replication (GO:0045071)3.28324474
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27737414
30positive regulation of chemokine biosynthetic process (GO:0045080)3.23089369
31regulation of vitamin metabolic process (GO:0030656)3.21593945
32macrophage activation involved in immune response (GO:0002281)3.16770364
33negative regulation of erythrocyte differentiation (GO:0045647)3.14808941
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.12694323
35natural killer cell mediated immunity (GO:0002228)3.10230517
36natural killer cell mediated cytotoxicity (GO:0042267)3.10230517
37hydrogen peroxide biosynthetic process (GO:0050665)3.07396139
38cellular response to exogenous dsRNA (GO:0071360)3.06424160
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.01862237
40regulation of chemokine biosynthetic process (GO:0045073)3.00403415
41reactive oxygen species biosynthetic process (GO:1903409)2.95497725
42regulation of RIG-I signaling pathway (GO:0039535)2.95371206
43positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.94126655
44NIK/NF-kappaB signaling (GO:0038061)2.92909496
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91232163
46response to host immune response (GO:0052572)2.91232163
47cellular response to virus (GO:0098586)2.84303010
48production of molecular mediator involved in inflammatory response (GO:0002532)2.82570993
49necroptotic process (GO:0070266)2.81577548
50interferon-gamma-mediated signaling pathway (GO:0060333)2.80646577
51ribosomal small subunit assembly (GO:0000028)2.80573980
52negative regulation of myeloid cell apoptotic process (GO:0033033)2.78845610
53defense response to protozoan (GO:0042832)2.77877176
54glycosphingolipid catabolic process (GO:0046479)2.76679035
55Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76611857
56granulocyte activation (GO:0036230)2.69289191
57positive regulation of B cell differentiation (GO:0045579)2.67318970
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65827446
59positive regulation of natural killer cell differentiation (GO:0032825)2.63944023
60protoporphyrinogen IX metabolic process (GO:0046501)2.63451168
61regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60839622
62response to host (GO:0075136)2.60442188
63response to host defenses (GO:0052200)2.60442188
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60442188
65response to protozoan (GO:0001562)2.58398849
66regulation of podosome assembly (GO:0071801)2.56976714
67cellular response to interferon-alpha (GO:0035457)2.55855883
68myeloid cell activation involved in immune response (GO:0002275)2.54851857
69glycolipid catabolic process (GO:0019377)2.54272812
70positive regulation of gamma-delta T cell activation (GO:0046645)2.53490000
71neutrophil activation (GO:0042119)2.52718680
72detection of molecule of bacterial origin (GO:0032490)2.52672919
73regulation of interferon-beta production (GO:0032648)2.51942349
74T-helper 1 type immune response (GO:0042088)2.51409715
75response to arsenic-containing substance (GO:0046685)2.50479234
763-UTR-mediated mRNA stabilization (GO:0070935)2.48589472
77superoxide anion generation (GO:0042554)2.48459990
78positive regulation of NF-kappaB import into nucleus (GO:0042346)2.48147796
79cellular response to zinc ion (GO:0071294)2.47230866
80regulation of integrin activation (GO:0033623)2.47006733
81response to muramyl dipeptide (GO:0032495)2.46601534
82negative regulation of growth of symbiont in host (GO:0044130)2.45617134
83negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.45617134
84modulation of growth of symbiont involved in interaction with host (GO:0044144)2.45617134
85regulation of growth of symbiont in host (GO:0044126)2.45617134
86regulation of chronic inflammatory response (GO:0002676)2.44724098
87positive regulation of antigen processing and presentation (GO:0002579)2.43639582
88regulation of mast cell degranulation (GO:0043304)2.43396505
89negative regulation of cytokine production involved in immune response (GO:0002719)2.43298983
90programmed necrotic cell death (GO:0097300)2.42740976
91regulation of T-helper 1 cell differentiation (GO:0045625)2.42654504
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42632745
93negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.42305443
94leukocyte mediated cytotoxicity (GO:0001909)2.42141231
95regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.40028848
96myeloid dendritic cell activation (GO:0001773)2.37552376
97oligosaccharide catabolic process (GO:0009313)2.37074399
98T cell migration (GO:0072678)2.36911624
99positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.36751514
100antigen processing and presentation via MHC class Ib (GO:0002475)2.35853191
101defense response to virus (GO:0051607)2.35798216
102cellular response to interferon-gamma (GO:0071346)2.35271428
103myeloid dendritic cell differentiation (GO:0043011)2.35188840
104regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.34930001
105regulation of interleukin-8 biosynthetic process (GO:0045414)2.34774052
106response to thyroid hormone (GO:0097066)2.33677991
107positive regulation of toll-like receptor signaling pathway (GO:0034123)2.31577340
108cellular response to thyroid hormone stimulus (GO:0097067)2.31332264
109positive regulation of interleukin-6 production (GO:0032755)2.30484229
110pinocytosis (GO:0006907)2.28497945
111regulation of heterotypic cell-cell adhesion (GO:0034114)2.28144254
112positive regulation of protein import into nucleus, translocation (GO:0033160)2.28032634
113response to interferon-gamma (GO:0034341)2.27439355
114regulation of cholesterol storage (GO:0010885)2.27234002
115low-density lipoprotein particle clearance (GO:0034383)2.27170883
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.26916370
117positive regulation of type I interferon production (GO:0032481)2.26308620
118cellular extravasation (GO:0045123)2.26003857
119positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.25957121
120lymphocyte mediated immunity (GO:0002449)2.25175124
121negative regulation of interleukin-12 production (GO:0032695)2.24581841
122monocyte chemotaxis (GO:0002548)2.24032410
123regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.24020883
124regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.23832485
125negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.23205579
126regulation of hypersensitivity (GO:0002883)2.22750606
127positive regulation of chemokine production (GO:0032722)2.22576015
128lymphocyte chemotaxis (GO:0048247)2.22445496
129regulation of mast cell activation involved in immune response (GO:0033006)2.22436068
130lipoxygenase pathway (GO:0019372)2.21185866
131regulation of response to interferon-gamma (GO:0060330)2.19697516
132hemoglobin metabolic process (GO:0020027)2.18748636
133defense response to Gram-positive bacterium (GO:0050830)2.18710925
134purine nucleotide salvage (GO:0032261)2.17252421
135positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.17102463
136regulation of leukocyte degranulation (GO:0043300)2.16795795
137ceramide catabolic process (GO:0046514)2.16578099
138mRNA transcription (GO:0009299)2.16248555
139nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.15489212
140regulation of cytokine secretion involved in immune response (GO:0002739)2.15296830
141nuclear pore complex assembly (GO:0051292)2.15091101
142regulation of interleukin-6 production (GO:0032675)2.14680656
143protein localization to endosome (GO:0036010)2.14086613
144necrotic cell death (GO:0070265)2.13003294
145detection of other organism (GO:0098543)2.12858113
146positive regulation of macrophage differentiation (GO:0045651)2.12167517
147leukocyte apoptotic process (GO:0071887)2.12001851
148GDP-mannose metabolic process (GO:0019673)2.11744456
149protoporphyrinogen IX biosynthetic process (GO:0006782)2.11219172
150cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.10390674
151mRNA transcription from RNA polymerase II promoter (GO:0042789)2.10168905
152negative regulation of nitric oxide biosynthetic process (GO:0045019)2.08876545
153regulation of interleukin-12 production (GO:0032655)2.08488623
154cellular response to lipopolysaccharide (GO:0071222)2.07304160
155negative regulation of interleukin-17 production (GO:0032700)2.07280848
156germinal center formation (GO:0002467)2.07193913
157mature B cell differentiation involved in immune response (GO:0002313)2.07161765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.36477859
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.17555958
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.47310315
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.38967911
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.35412887
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.75313643
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.69171806
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.67347768
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48927862
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.48537677
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48520848
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45703448
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.43891351
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42655774
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40574186
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15387477
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05063250
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00653888
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99934326
20* SPI1_23547873_ChIP-Seq_NB4_Human1.92748372
21* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87009437
22SCL_19346495_ChIP-Seq_HPC-7_Human1.84792989
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.84166853
24GATA1_22025678_ChIP-Seq_K562_Human1.80486306
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78270018
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72611023
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72175580
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.71732739
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68073056
30* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67519361
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67058334
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61340879
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60417721
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60042026
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57666480
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57166284
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55048234
38VDR_21846776_ChIP-Seq_THP-1_Human1.54743505
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.54659190
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54581527
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54553978
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54006121
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47249886
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47018694
45* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46376258
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45598160
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44156717
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44123097
49* MYB_26560356_Chip-Seq_TH2_Human1.41870557
50MYC_22102868_ChIP-Seq_BL_Human1.41764167
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.40633775
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37427280
53VDR_24763502_ChIP-Seq_THP-1_Human1.35491906
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34805451
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34613339
56MAF_26560356_Chip-Seq_TH1_Human1.34301667
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34002643
58ZNF263_19887448_ChIP-Seq_K562_Human1.32763028
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31018214
60* MYB_26560356_Chip-Seq_TH1_Human1.30853988
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30581809
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.29368109
63GATA1_19941826_ChIP-Seq_K562_Human1.27879752
64TCF7_22412390_ChIP-Seq_EML_Mouse1.25078185
65NCOR1_26117541_ChIP-Seq_K562_Human1.24791201
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24626389
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.24597612
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24582090
69* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24028988
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22569627
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22106066
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21903396
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21370303
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18757336
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16949903
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16496031
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.14619459
78TFEB_21752829_ChIP-Seq_HELA_Human1.13855948
79PU_27001747_Chip-Seq_BMDM_Mouse1.13460563
80AR_21909140_ChIP-Seq_LNCAP_Human1.13060622
81VDR_23849224_ChIP-Seq_CD4+_Human1.12801498
82* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12766169
83SPI1_23127762_ChIP-Seq_K562_Human1.12376768
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11199861
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08887641
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08806100
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06792099
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.06615796
89ATF3_27146783_Chip-Seq_COLON_Human1.05738827
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05687551
91UTX_26944678_Chip-Seq_JUKART_Human1.05471668
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05099148
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.04447669
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03830485
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.02979293
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02629100
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02045510
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01964851
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00464531
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99242787
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98851031
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98449074
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98163460
104* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98124166
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97219375
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97219375
107SRF_21415370_ChIP-Seq_HL-1_Mouse0.96383842
108DCP1A_22483619_ChIP-Seq_HELA_Human0.96303118
109ELK1_19687146_ChIP-ChIP_HELA_Human0.94646265
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94587226
111* XRN2_22483619_ChIP-Seq_HELA_Human0.94432518
112ETS1_20019798_ChIP-Seq_JURKAT_Human0.93812222
113CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93044827
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92360777
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.91988571
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90373429
117FOXP3_21729870_ChIP-Seq_TREG_Human0.90295644
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89801679
119* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89724600
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88774311
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87577720
122MAF_26560356_Chip-Seq_TH2_Human0.87562747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.63145471
2MP0009785_altered_susceptibility_to3.33253526
3MP0003436_decreased_susceptibility_to3.23259856
4MP0003724_increased_susceptibility_to2.94451599
5MP0002148_abnormal_hypersensitivity_rea2.64799806
6MP0005025_abnormal_response_to2.53544915
7MP0002419_abnormal_innate_immunity2.46805748
8MP0006082_CNS_inflammation2.42811576
9MP0000685_abnormal_immune_system2.42589604
10MP0005000_abnormal_immune_tolerance2.38837041
11MP0003303_peritoneal_inflammation2.28238045
12MP0002452_abnormal_antigen_presenting2.18147073
13MP0001800_abnormal_humoral_immune2.15273410
14MP0001790_abnormal_immune_system2.07061636
15MP0005387_immune_system_phenotype2.07061636
16MP0009840_abnormal_foam_cell2.04799486
17MP0002723_abnormal_immune_serum2.04614738
18MP0005464_abnormal_platelet_physiology2.03148197
19MP0003191_abnormal_cellular_cholesterol2.00730964
20MP0005671_abnormal_response_to1.99968686
21MP0001853_heart_inflammation1.94325082
22MP0003186_abnormal_redox_activity1.92137399
23MP0001545_abnormal_hematopoietic_system1.89419364
24MP0005397_hematopoietic_system_phenotyp1.89419364
25MP0009764_decreased_sensitivity_to1.82698511
26* MP0001819_abnormal_immune_cell1.82292968
27* MP0002420_abnormal_adaptive_immunity1.79829624
28MP0002877_abnormal_melanocyte_morpholog1.79829599
29MP0005360_urolithiasis1.78583779
30MP0005058_abnormal_lysosome_morphology1.78523343
31MP0001533_abnormal_skeleton_physiology1.77826300
32MP0003806_abnormal_nucleotide_metabolis1.70518758
33MP0008469_abnormal_protein_level1.69159932
34MP0001845_abnormal_inflammatory_respons1.65812165
35MP0003453_abnormal_keratinocyte_physiol1.65084791
36MP0009333_abnormal_splenocyte_physiolog1.64000498
37MP0004947_skin_inflammation1.63190213
38MP0002006_tumorigenesis1.62984430
39MP0010155_abnormal_intestine_physiology1.59433395
40MP0010307_abnormal_tumor_latency1.57363150
41* MP0002398_abnormal_bone_marrow1.52771041
42MP0002405_respiratory_system_inflammati1.52543289
43MP0002139_abnormal_hepatobiliary_system1.49191970
44MP0009278_abnormal_bone_marrow1.48813336
45MP0002396_abnormal_hematopoietic_system1.47107306
46* MP0000716_abnormal_immune_system1.46792491
47MP0008260_abnormal_autophagy1.46388086
48MP0003693_abnormal_embryo_hatching1.46014925
49MP0000343_altered_response_to1.46006661
50MP0010352_gastrointestinal_tract_polyps1.44675488
51MP0002166_altered_tumor_susceptibility1.41981889
52MP0003448_altered_tumor_morphology1.41346207
53MP0000689_abnormal_spleen_morphology1.41310767
54MP0000858_altered_metastatic_potential1.41036825
55* MP0002429_abnormal_blood_cell1.32670089
56MP0003656_abnormal_erythrocyte_physiolo1.31885462
57MP0003828_pulmonary_edema1.29136256
58MP0000490_abnormal_crypts_of1.29073332
59* MP0002722_abnormal_immune_system1.28369258
60MP0006054_spinal_hemorrhage1.27859622
61MP0005310_abnormal_salivary_gland1.27107004
62MP0004808_abnormal_hematopoietic_stem1.26668715
63MP0003950_abnormal_plasma_membrane1.26657476
64MP0008004_abnormal_stomach_pH1.25484622
65MP0003075_altered_response_to1.21929452
66MP0010234_abnormal_vibrissa_follicle1.20821743
67MP0005076_abnormal_cell_differentiation1.16441171
68MP0004185_abnormal_adipocyte_glucose1.15261538
69MP0002796_impaired_skin_barrier1.15145627
70MP0009763_increased_sensitivity_to1.13100960
71MP0003172_abnormal_lysosome_physiology1.11053237
72MP0002254_reproductive_system_inflammat1.07151285
73MP0005167_abnormal_blood-brain_barrier1.05960702
74MP0004147_increased_porphyrin_level1.05799957
75MP0003300_gastrointestinal_ulcer1.02847999
76MP0005166_decreased_susceptibility_to1.01299392
77MP0005501_abnormal_skin_physiology1.00869145
78MP0005164_abnormal_response_to1.00044344
79MP0004510_myositis0.99932971
80MP0010094_abnormal_chromosome_stability0.99566742
81MP0001216_abnormal_epidermal_layer0.99417726
82* MP0000703_abnormal_thymus_morphology0.97793393
83MP0005319_abnormal_enzyme/_coenzyme0.97724715
84MP0000609_abnormal_liver_physiology0.96868344
85MP0005085_abnormal_gallbladder_physiolo0.96417212
86MP0003786_premature_aging0.96206560
87MP0004782_abnormal_surfactant_physiolog0.95587485
88MP0003566_abnormal_cell_adhesion0.95491725
89MP0003077_abnormal_cell_cycle0.94950217
90MP0008438_abnormal_cutaneous_collagen0.94682053
91MP0005023_abnormal_wound_healing0.93233428
92MP0002019_abnormal_tumor_incidence0.92985419
93MP0008875_abnormal_xenobiotic_pharmacok0.91356475
94MP0008057_abnormal_DNA_replication0.90827125
95MP0008007_abnormal_cellular_replicative0.89529573
96MP0009765_abnormal_xenobiotic_induced0.89172908
97MP0005083_abnormal_biliary_tract0.88620200
98MP0002998_abnormal_bone_remodeling0.88568250
99MP0003705_abnormal_hypodermis_morpholog0.87890760
100MP0000598_abnormal_liver_morphology0.87816858
101MP0001851_eye_inflammation0.87648964
102MP0005165_increased_susceptibility_to0.87177728
103MP0005451_abnormal_body_composition0.85531242
104MP0005390_skeleton_phenotype0.84036344
105MP0005365_abnormal_bile_salt0.83116287
106* MP0003763_abnormal_thymus_physiology0.83050578
107MP0002138_abnormal_hepatobiliary_system0.82782484
108MP0000313_abnormal_cell_death0.80517563
109MP0000465_gastrointestinal_hemorrhage0.80422139
110MP0004264_abnormal_extraembryonic_tissu0.80311964
111MP0001849_ear_inflammation0.80010628
112MP0000249_abnormal_blood_vessel0.79908683
113MP0009931_abnormal_skin_appearance0.78886865
114MP0004957_abnormal_blastocyst_morpholog0.78073374
115MP0003111_abnormal_nucleus_morphology0.77779689
116MP0003195_calcinosis0.76852525
117MP0010329_abnormal_lipoprotein_level0.76066963
118MP0001873_stomach_inflammation0.73358175
119* MP0002136_abnormal_kidney_physiology0.72978594
120MP0001764_abnormal_homeostasis0.72591342
121* MP0009643_abnormal_urine_homeostasis0.70749632
122MP0000604_amyloidosis0.70686266
123MP0008873_increased_physiological_sensi0.69286343
124MP0002933_joint_inflammation0.67385507

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.18704682
2Recurrent bacterial skin infections (HP:0005406)4.99961721
3Eczematoid dermatitis (HP:0000976)4.99101384
4Recurrent gram-negative bacterial infections (HP:0005420)4.78958808
5Elevated erythrocyte sedimentation rate (HP:0003565)4.37840261
6Abnormality of glycolipid metabolism (HP:0010969)4.06327583
7Abnormality of liposaccharide metabolism (HP:0010968)4.06327583
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.06327583
9Systemic lupus erythematosus (HP:0002725)3.94417562
10Abnormality of macrophages (HP:0004311)3.81196234
11Mediastinal lymphadenopathy (HP:0100721)3.63327555
12Vacuolated lymphocytes (HP:0001922)3.36466739
13Myositis (HP:0100614)3.30392777
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.25848821
15Thrombocytosis (HP:0001894)3.23825273
16Recurrent skin infections (HP:0001581)3.19476140
17Cellulitis (HP:0100658)3.19412739
18Petechiae (HP:0000967)3.18348398
19Chronic otitis media (HP:0000389)3.06291943
20Interstitial pulmonary disease (HP:0006530)3.00500350
21Basal ganglia calcification (HP:0002135)2.97191933
22Recurrent fungal infections (HP:0002841)2.96381343
23Stomatitis (HP:0010280)2.80594387
24Abnormality of the heme biosynthetic pathway (HP:0010472)2.75725971
25Poor head control (HP:0002421)2.74693617
26Nausea (HP:0002018)2.73454577
27Gingival bleeding (HP:0000225)2.73020169
28Orchitis (HP:0100796)2.72035204
29Urticaria (HP:0001025)2.70831801
30Gingivitis (HP:0000230)2.69047850
31* Recurrent viral infections (HP:0004429)2.64863897
32Pustule (HP:0200039)2.63450978
33Joint hemorrhage (HP:0005261)2.61300827
34Loss of speech (HP:0002371)2.59777426
35Prostate neoplasm (HP:0100787)2.59613592
36Paralysis (HP:0003470)2.59213820
37Increased cerebral lipofuscin (HP:0011813)2.58087418
38* Vasculitis (HP:0002633)2.54907844
39Chronic obstructive pulmonary disease (HP:0006510)2.54788774
40Obstructive lung disease (HP:0006536)2.54788774
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.54582060
42Periodontitis (HP:0000704)2.52169249
43Glomerulonephritis (HP:0000099)2.52144302
44Dysostosis multiplex (HP:0000943)2.50971240
45Increased serum ferritin (HP:0003281)2.48768068
46IgM deficiency (HP:0002850)2.45995848
47Purpura (HP:0000979)2.44196030
48Myocardial infarction (HP:0001658)2.42552116
49Epistaxis (HP:0000421)2.39648307
50Meningitis (HP:0001287)2.37794484
51Osteomyelitis (HP:0002754)2.37655026
52Rough bone trabeculation (HP:0100670)2.35430973
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34916561
54Oral leukoplakia (HP:0002745)2.34754683
55Polycythemia (HP:0001901)2.33659019
56Axonal loss (HP:0003447)2.33496620
57Abnormality of the prostate (HP:0008775)2.32940045
58Increased IgM level (HP:0003496)2.31692644
59Abnormality of iron homeostasis (HP:0011031)2.31569972
60Agnosia (HP:0010524)2.28909787
61Hypergammaglobulinemia (HP:0010702)2.26340485
62Complement deficiency (HP:0004431)2.25886803
63* Autoimmune thrombocytopenia (HP:0001973)2.25145453
64Recurrent pneumonia (HP:0006532)2.23469390
65Increased IgE level (HP:0003212)2.21529293
66Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20538743
67Prolonged bleeding time (HP:0003010)2.19855055
68Hypertensive crisis (HP:0100735)2.19788045
69Thick nail (HP:0001805)2.19492384
70Recurrent bronchitis (HP:0002837)2.19095757
71Progressive external ophthalmoplegia (HP:0000590)2.18965843
72Abnormal number of erythroid precursors (HP:0012131)2.17776117
73Abnormality of cells of the erythroid lineage (HP:0012130)2.16251062
74Conjunctival telangiectasia (HP:0000524)2.15681821
75Abnormality of complement system (HP:0005339)2.14261262
76Poikilocytosis (HP:0004447)2.12751819
77Gastrointestinal infarctions (HP:0005244)2.12183736
78Abnormality of pyrimidine metabolism (HP:0004353)2.12107830
79Reticulocytopenia (HP:0001896)2.11665129
80Abnormal trabecular bone morphology (HP:0100671)2.11421149
81Hepatosplenomegaly (HP:0001433)2.10487149
82Abnormality of the nasal mucosa (HP:0000433)2.10108577
83Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06061613
84Keratoconjunctivitis sicca (HP:0001097)2.05686186
85Retrobulbar optic neuritis (HP:0100654)2.05185782
86Optic neuritis (HP:0100653)2.05185782
87Hematochezia (HP:0002573)2.05114255
88Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05005576
89Chronic mucocutaneous candidiasis (HP:0002728)2.04146667
90Recurrent cutaneous fungal infections (HP:0011370)2.04146667
91Keratoconjunctivitis (HP:0001096)2.03894418
92Leukocytosis (HP:0001974)2.03563526
93Abnormality of transition element cation homeostasis (HP:0011030)2.03309869
94Amyloidosis (HP:0011034)2.03233490
95Abnormality of nail color (HP:0100643)2.02869626
96Impaired platelet aggregation (HP:0003540)2.02716612
97Abnormal platelet function (HP:0011869)2.02716612
98Nasal polyposis (HP:0100582)2.00718223
99Skin ulcer (HP:0200042)1.99948745
100Spontaneous hematomas (HP:0007420)1.99414185
101Arterial thrombosis (HP:0004420)1.99389859
102Esophageal neoplasm (HP:0100751)1.99363736
103Neoplasm of head and neck (HP:0012288)1.99363736
104Reticulocytosis (HP:0001923)1.99106553
105Osteolytic defects of the phalanges of the hand (HP:0009771)1.97538465
106Osteolytic defects of the hand bones (HP:0009699)1.97538465
107Nephritis (HP:0000123)1.96440321
108Aplastic anemia (HP:0001915)1.94120986
109Peritonitis (HP:0002586)1.93580180
110Anorexia (HP:0002039)1.93450451
111Microcytic anemia (HP:0001935)1.92906953
112Pallor (HP:0000980)1.92887652
113Congenital ichthyosiform erythroderma (HP:0007431)1.92431381
114Pulmonary infiltrates (HP:0002113)1.91903048
115Vertebral compression fractures (HP:0002953)1.90881783
116Disinhibition (HP:0000734)1.90742399
117T lymphocytopenia (HP:0005403)1.88851482
118Esophageal varix (HP:0002040)1.86887961
119Xanthomatosis (HP:0000991)1.86476513
120Erythema (HP:0010783)1.85771403
121Thrombophlebitis (HP:0004418)1.85488111
122Abnormal platelet volume (HP:0011876)1.84510631
123Gangrene (HP:0100758)1.84250845
124* Recurrent lower respiratory tract infections (HP:0002783)1.84168316
125* Abnormality of T cell physiology (HP:0011840)1.83655405
126Fatigue (HP:0012378)1.80038664
127IgA deficiency (HP:0002720)1.79410517
128Abnormality of reticulocytes (HP:0004312)1.78784341
129Urinary glycosaminoglycan excretion (HP:0003541)1.78687855
130Mucopolysacchariduria (HP:0008155)1.78687855
131Eosinophilia (HP:0001880)1.78508144
132Granulocytopenia (HP:0001913)1.78410481
133Squamous cell carcinoma (HP:0002860)1.78311048
134Reduced antithrombin III activity (HP:0001976)1.76656615
135Cholecystitis (HP:0001082)1.76208431
136Abnormal gallbladder physiology (HP:0012438)1.76208431
137Cholelithiasis (HP:0001081)1.75467407
138Abnormality of T cell number (HP:0011839)1.75236304
139Encephalitis (HP:0002383)1.75130333
140Mucosal telangiectasiae (HP:0100579)1.75078931
141Abnormal blistering of the skin (HP:0008066)1.73460653
142Skin rash (HP:0000988)1.72925918
143* Autoimmune hemolytic anemia (HP:0001890)1.72334789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK13.02259358
2ERN12.96873937
3TYK22.95959841
4NME22.80087353
5MAP3K142.64894555
6PBK2.62550675
7MAP4K12.60733996
8PRPF4B2.60448399
9BLK2.57500382
10TAOK22.40771748
11IKBKE2.38334850
12IRAK32.30211520
13PIM22.29386166
14IRAK42.26057047
15JAK32.20701984
16KIT2.09190617
17RPS6KA41.83117514
18IKBKB1.82299552
19ZAP701.64681977
20RIPK41.52727104
21MAP2K31.49535381
22TGFBR21.42850154
23STK101.42431389
24TIE11.40599142
25WEE11.40035232
26SMG11.37826905
27EIF2AK11.37667233
28PIM11.37602977
29MAP3K101.37359378
30BMPR21.35891565
31NEK91.34310312
32BTK1.33599334
33JAK11.33131013
34CSF1R1.31284085
35TEC1.30906095
36STK41.30570842
37FLT31.30195957
38KDR1.28962418
39NEK11.28861686
40TGFBR11.28715157
41ACVR1B1.27324215
42CDK121.26909436
43EEF2K1.23161688
44TAOK11.22825803
45FGFR41.20936445
46TAOK31.18917055
47MOS1.18541347
48TXK1.18387289
49SYK1.18369198
50MAP3K11.14533758
51EPHA21.13497218
52NEK21.12118450
53STK241.11313101
54LRRK21.09367414
55CSK1.06176159
56ABL21.00894909
57PKN21.00635856
58LYN1.00569397
59CHUK1.00006554
60MAP3K110.99435742
61FGR0.97756228
62BUB10.96881268
63MATK0.96209111
64CLK10.95250280
65TSSK60.94615093
66MST40.92553420
67GRK70.91373427
68CDK40.91232089
69PDK20.90350095
70JAK20.88819912
71EIF2AK20.86780528
72HCK0.85260595
73BMX0.84928592
74CDC70.83802919
75IRAK20.82081672
76LCK0.81888040
77EIF2AK30.81031704
78SCYL20.77897330
79MAPKAPK30.77522071
80SIK30.77292323
81MAP3K80.76363220
82MST1R0.75500771
83BCKDK0.74423656
84MAP3K130.71002248
85CDK60.69908696
86MAP3K50.68552428
87RPS6KB20.68059079
88FGFR30.67708970
89STK160.67561469
90STK30.66113536
91ATR0.65656283
92MAPK110.64733071
93MAP3K30.63660954
94VRK10.63032129
95MAP3K120.62749236
96MARK30.59347354
97BRAF0.59004397
98DYRK30.58512191
99BRSK20.57508279
100ARAF0.57159921
101ITK0.56254246
102CDK70.55614834
103EPHB10.54079151
104PAK40.52605352
105SRPK10.52450443
106MAPK40.51598245
107CHEK20.51483122
108AURKB0.50672365
109NLK0.50359130
110TRPM70.50353351
111TESK20.49889054
112PIK3CG0.49814343
113TTK0.49642705
114RIPK10.48766309
115TRIB30.47864171
116ABL10.47788805
117GRK60.47288360
118PRKCD0.45575533
119AURKA0.45509945
120MAPKAPK20.43339033
121TLK10.41618040
122FES0.41564746
123EGFR0.39477499
124RPS6KA50.39219235
125PRKG20.38857245
126IRAK10.38097746
127ICK0.38084608
128GSK3A0.36357521
129LATS20.32458134
130DAPK10.32337353
131PAK10.31911219
132PDPK10.30723591
133CHEK10.30112795

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.84593895
2Staphylococcus aureus infection_Homo sapiens_hsa051502.71865050
3Leishmaniasis_Homo sapiens_hsa051402.64101245
4DNA replication_Homo sapiens_hsa030302.28190611
5Legionellosis_Homo sapiens_hsa051342.22993462
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.17918962
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04364068
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.03619222
9Graft-versus-host disease_Homo sapiens_hsa053321.93218524
10Measles_Homo sapiens_hsa051621.85402291
11Malaria_Homo sapiens_hsa051441.84890270
12Pertussis_Homo sapiens_hsa051331.78117188
13Herpes simplex infection_Homo sapiens_hsa051681.75406743
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67477854
15Ribosome_Homo sapiens_hsa030101.63588334
16Influenza A_Homo sapiens_hsa051641.63472159
17Allograft rejection_Homo sapiens_hsa053301.58865362
18Antigen processing and presentation_Homo sapiens_hsa046121.57207760
19One carbon pool by folate_Homo sapiens_hsa006701.56479240
20Caffeine metabolism_Homo sapiens_hsa002321.55811475
21Proteasome_Homo sapiens_hsa030501.54176411
22Bladder cancer_Homo sapiens_hsa052191.52110736
23Osteoclast differentiation_Homo sapiens_hsa043801.50381928
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.42525263
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39902907
26Mismatch repair_Homo sapiens_hsa034301.39397995
27Tuberculosis_Homo sapiens_hsa051521.37565216
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36671403
29Complement and coagulation cascades_Homo sapiens_hsa046101.36450160
30TNF signaling pathway_Homo sapiens_hsa046681.35783316
31Folate biosynthesis_Homo sapiens_hsa007901.34294449
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29402710
33Base excision repair_Homo sapiens_hsa034101.25566270
34Asthma_Homo sapiens_hsa053101.24233993
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.22309550
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21478734
37Hematopoietic cell lineage_Homo sapiens_hsa046401.19806240
38Other glycan degradation_Homo sapiens_hsa005111.18426260
39Apoptosis_Homo sapiens_hsa042101.15662010
40Toxoplasmosis_Homo sapiens_hsa051451.15293521
41Primary immunodeficiency_Homo sapiens_hsa053401.12898284
42African trypanosomiasis_Homo sapiens_hsa051431.10140759
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.05990537
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.05666352
45Lysosome_Homo sapiens_hsa041421.04767201
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04219450
47Rheumatoid arthritis_Homo sapiens_hsa053231.04165328
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03645720
49Homologous recombination_Homo sapiens_hsa034401.03013014
50Chronic myeloid leukemia_Homo sapiens_hsa052201.02898187
51Pentose phosphate pathway_Homo sapiens_hsa000301.01573573
52T cell receptor signaling pathway_Homo sapiens_hsa046601.01393299
53B cell receptor signaling pathway_Homo sapiens_hsa046620.99804749
54Salmonella infection_Homo sapiens_hsa051320.97109391
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.96649106
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95972446
57Pancreatic cancer_Homo sapiens_hsa052120.95280157
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94275125
59* Pyrimidine metabolism_Homo sapiens_hsa002400.92614921
60Sulfur relay system_Homo sapiens_hsa041220.92318970
61Hepatitis B_Homo sapiens_hsa051610.91122231
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89783036
63Shigellosis_Homo sapiens_hsa051310.89742657
64Hepatitis C_Homo sapiens_hsa051600.86661895
65Selenocompound metabolism_Homo sapiens_hsa004500.84572430
66Fructose and mannose metabolism_Homo sapiens_hsa000510.83071255
67* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81643709
68p53 signaling pathway_Homo sapiens_hsa041150.81462735
69Sulfur metabolism_Homo sapiens_hsa009200.81039100
70Type I diabetes mellitus_Homo sapiens_hsa049400.80450270
71HTLV-I infection_Homo sapiens_hsa051660.79071005
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78472005
73Prion diseases_Homo sapiens_hsa050200.77943302
74Phagosome_Homo sapiens_hsa041450.77348685
75Peroxisome_Homo sapiens_hsa041460.77089195
76Arginine biosynthesis_Homo sapiens_hsa002200.76322479
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75114148
78Sphingolipid metabolism_Homo sapiens_hsa006000.72492848
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72454762
80HIF-1 signaling pathway_Homo sapiens_hsa040660.72091800
81RNA transport_Homo sapiens_hsa030130.71580845
82Nucleotide excision repair_Homo sapiens_hsa034200.68285659
83Epstein-Barr virus infection_Homo sapiens_hsa051690.67144473
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65905316
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65556928
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64339643
87Systemic lupus erythematosus_Homo sapiens_hsa053220.63942970
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63792300
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61072554
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60428649
91Glutathione metabolism_Homo sapiens_hsa004800.59710617
92Non-small cell lung cancer_Homo sapiens_hsa052230.59529366
93Non-homologous end-joining_Homo sapiens_hsa034500.57404773
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56580799
95VEGF signaling pathway_Homo sapiens_hsa043700.56571029
96Cell cycle_Homo sapiens_hsa041100.56497010
97Histidine metabolism_Homo sapiens_hsa003400.56142081
98Viral myocarditis_Homo sapiens_hsa054160.54631919
99Viral carcinogenesis_Homo sapiens_hsa052030.53547742
100Nitrogen metabolism_Homo sapiens_hsa009100.53359344
101Spliceosome_Homo sapiens_hsa030400.53151844
102Acute myeloid leukemia_Homo sapiens_hsa052210.52632679
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52068962
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51311241
105Chemical carcinogenesis_Homo sapiens_hsa052040.50816593
106Small cell lung cancer_Homo sapiens_hsa052220.49604836
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.49064001
108Chemokine signaling pathway_Homo sapiens_hsa040620.48259704
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47120308
110Platelet activation_Homo sapiens_hsa046110.46693539
111Renal cell carcinoma_Homo sapiens_hsa052110.45871782
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44580825
113Tryptophan metabolism_Homo sapiens_hsa003800.43413333
114Autoimmune thyroid disease_Homo sapiens_hsa053200.43263874
115RNA polymerase_Homo sapiens_hsa030200.42702384
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42621818
117PPAR signaling pathway_Homo sapiens_hsa033200.42195763
118Vitamin digestion and absorption_Homo sapiens_hsa049770.41906497
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41463574
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41400671
121Amoebiasis_Homo sapiens_hsa051460.41310776
122Galactose metabolism_Homo sapiens_hsa000520.40742718
123Fatty acid degradation_Homo sapiens_hsa000710.40171332

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