PNPLA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)7.23901050
2* regulation of sequestering of triglyceride (GO:0010889)7.07673017
3fatty acid transmembrane transport (GO:1902001)6.69324091
4carnitine shuttle (GO:0006853)6.65533756
5valine metabolic process (GO:0006573)6.64430091
6biotin metabolic process (GO:0006768)6.43359536
7brown fat cell differentiation (GO:0050873)6.10780088
8fatty acid beta-oxidation (GO:0006635)5.84844119
9carnitine transmembrane transport (GO:1902603)5.47626810
10white fat cell differentiation (GO:0050872)5.46237272
11tricarboxylic acid cycle (GO:0006099)5.45514555
12positive regulation of fatty acid oxidation (GO:0046321)5.29161150
13regulation of fatty acid oxidation (GO:0046320)5.22562682
14NADH metabolic process (GO:0006734)5.14781318
15regulation of cholesterol storage (GO:0010885)5.14729809
16* triglyceride catabolic process (GO:0019433)5.13862322
17carnitine transport (GO:0015879)5.13491104
18amino-acid betaine transport (GO:0015838)5.13491104
19positive regulation of fatty acid beta-oxidation (GO:0032000)5.09131727
20fatty acid oxidation (GO:0019395)5.07872849
21lipid oxidation (GO:0034440)4.98754631
22fatty acid catabolic process (GO:0009062)4.97549868
23branched-chain amino acid catabolic process (GO:0009083)4.95600928
24branched-chain amino acid metabolic process (GO:0009081)4.91741558
25regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.74376095
26tricarboxylic acid metabolic process (GO:0072350)4.64221448
27* acylglycerol catabolic process (GO:0046464)4.58385326
28* neutral lipid catabolic process (GO:0046461)4.58385326
29diacylglycerol metabolic process (GO:0046339)4.57903748
30acetyl-CoA metabolic process (GO:0006084)4.40609871
31triglyceride biosynthetic process (GO:0019432)4.33091457
32negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.30932716
332-oxoglutarate metabolic process (GO:0006103)4.29697550
34alpha-linolenic acid metabolic process (GO:0036109)4.18669409
35negative regulation of erythrocyte differentiation (GO:0045647)4.17977999
36regulation of acyl-CoA biosynthetic process (GO:0050812)4.17866730
37positive regulation of lipid storage (GO:0010884)4.17105119
38thioester biosynthetic process (GO:0035384)4.15399494
39acyl-CoA biosynthetic process (GO:0071616)4.15399494
40regulation of fatty acid beta-oxidation (GO:0031998)4.14769396
41acylglycerol biosynthetic process (GO:0046463)4.14312785
42neutral lipid biosynthetic process (GO:0046460)4.14312785
43intracellular lipid transport (GO:0032365)4.02441326
44quaternary ammonium group transport (GO:0015697)3.98402041
45oxaloacetate metabolic process (GO:0006107)3.94865756
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.94192718
47monocarboxylic acid catabolic process (GO:0072329)3.93135945
48carnitine metabolic process (GO:0009437)3.92456812
49* lipid particle organization (GO:0034389)3.87694042
50succinate metabolic process (GO:0006105)3.86257940
51regulation of coenzyme metabolic process (GO:0051196)3.84175130
52regulation of cofactor metabolic process (GO:0051193)3.84175130
53positive regulation of fatty acid metabolic process (GO:0045923)3.71731571
54lysine catabolic process (GO:0006554)3.70163642
55lysine metabolic process (GO:0006553)3.70163642
56pentose-phosphate shunt (GO:0006098)3.67904142
57fatty acid homeostasis (GO:0055089)3.64672213
58coenzyme A biosynthetic process (GO:0015937)3.62928346
59fatty-acyl-CoA biosynthetic process (GO:0046949)3.60337914
60plasma lipoprotein particle clearance (GO:0034381)3.58517076
61regulation of triglyceride biosynthetic process (GO:0010866)3.56518879
62positive regulation of cholesterol efflux (GO:0010875)3.52351098
63fatty-acyl-CoA metabolic process (GO:0035337)3.51075721
64short-chain fatty acid metabolic process (GO:0046459)3.49184480
65NADPH regeneration (GO:0006740)3.48691574
66* triglyceride metabolic process (GO:0006641)3.44826472
67barbed-end actin filament capping (GO:0051016)3.44403632
68long-chain fatty acid transport (GO:0015909)3.39871155
69* lipid storage (GO:0019915)3.37958516
70positive regulation of triglyceride lipase activity (GO:0061365)3.35937934
71positive regulation of lipoprotein lipase activity (GO:0051006)3.35937934
72negative regulation of protein autophosphorylation (GO:0031953)3.35470193
73mannose metabolic process (GO:0006013)3.28535636
74* acylglycerol metabolic process (GO:0006639)3.23691301
75regulation of macrophage derived foam cell differentiation (GO:0010743)3.18079177
76cellular response to epinephrine stimulus (GO:0071872)3.17521835
77* neutral lipid metabolic process (GO:0006638)3.17130211
78complement activation, alternative pathway (GO:0006957)3.16242737
79amino-acid betaine metabolic process (GO:0006577)3.15418266
80regulation of fatty acid metabolic process (GO:0019217)3.14629034
81regulation of sulfur metabolic process (GO:0042762)3.12745118
82negative regulation of granulocyte differentiation (GO:0030853)3.11740998
83* glycerolipid catabolic process (GO:0046503)3.09239464
84cardiolipin metabolic process (GO:0032048)3.08411635
85sulfur amino acid catabolic process (GO:0000098)3.05853968
86long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.05384343
87thioester metabolic process (GO:0035383)3.01685108
88acyl-CoA metabolic process (GO:0006637)3.01685108
89antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.01682459
90ethanol oxidation (GO:0006069)3.01673738
91coenzyme A metabolic process (GO:0015936)3.01501922
92long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.98808093
93regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.98675217
94transcytosis (GO:0045056)2.97438290
95cellular response to lithium ion (GO:0071285)2.96292363
96* cellular lipid catabolic process (GO:0044242)2.96148662
97fatty acid transport (GO:0015908)2.93424387
98stress fiber assembly (GO:0043149)2.92844076
99regulation of glycogen (starch) synthase activity (GO:2000465)2.92768439
100acylglycerol homeostasis (GO:0055090)2.91715568
101triglyceride homeostasis (GO:0070328)2.91715568
102protein heterotrimerization (GO:0070208)2.89851109
103positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88252069
104cellular response to zinc ion (GO:0071294)2.87645327
105antigen processing and presentation of endogenous antigen (GO:0019883)2.86061579
106growth hormone receptor signaling pathway (GO:0060396)2.85801652
107* regulation of lipid storage (GO:0010883)2.83206391
108* positive regulation of lipid catabolic process (GO:0050996)2.83082076
109positive regulation of histone deacetylation (GO:0031065)2.82765678
110positive regulation of cholesterol transport (GO:0032376)2.82657968
111positive regulation of sterol transport (GO:0032373)2.82657968
112glucose catabolic process (GO:0006007)2.79190435
113negative regulation of phagocytosis (GO:0050765)2.77563824
114positive regulation of triglyceride biosynthetic process (GO:0010867)2.76836427
115negative regulation of fatty acid biosynthetic process (GO:0045717)2.76633036
116regulation of cholesterol metabolic process (GO:0090181)2.76513679
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75006876
118negative regulation of smooth muscle cell migration (GO:0014912)2.73781758
119negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.69182252
120polyol transport (GO:0015791)2.65441949
121angiogenesis involved in wound healing (GO:0060055)2.64549745
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62918379
123negative regulation of cell killing (GO:0031342)2.62918379
124CDP-diacylglycerol metabolic process (GO:0046341)2.59268041
125positive regulation of receptor recycling (GO:0001921)2.58830225
126cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.54580043
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.53195288
128negative regulation of fatty acid transport (GO:2000192)2.52119308
129regulation of extracellular matrix disassembly (GO:0010715)2.50907521
130ethanol metabolic process (GO:0006067)2.48466086
131negative regulation of tumor necrosis factor production (GO:0032720)2.47084950
132fibril organization (GO:0097435)2.45493598
133negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.45168035
134response to epinephrine (GO:0071871)2.44123741
135negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.43929548
136regulation of glucose import in response to insulin stimulus (GO:2001273)2.41363729
137negative regulation of smooth muscle cell proliferation (GO:0048662)2.41322932
138positive regulation of gamma-delta T cell activation (GO:0046645)2.40945424
139apoptotic cell clearance (GO:0043277)2.33664700
140response to laminar fluid shear stress (GO:0034616)2.31175538
141regulation of cholesterol efflux (GO:0010874)2.30158216
142apoptotic process involved in morphogenesis (GO:0060561)2.29559300
143extracellular fibril organization (GO:0043206)2.29082448
144regulation of necrotic cell death (GO:0010939)2.27618869
145creatine metabolic process (GO:0006600)2.27598398
146detection of bacterium (GO:0016045)2.27389604
147CDP-diacylglycerol biosynthetic process (GO:0016024)2.26984651
148detection of other organism (GO:0098543)2.26621637
149adherens junction assembly (GO:0034333)2.26336150
150focal adhesion assembly (GO:0048041)2.24753922
151cell-substrate adherens junction assembly (GO:0007045)2.24753922
152regulation of receptor binding (GO:1900120)2.24111132
153positive regulation of cellular response to insulin stimulus (GO:1900078)2.23320011
154regulation of gamma-delta T cell differentiation (GO:0045586)2.23138623
155basement membrane organization (GO:0071711)2.22895300
156vascular endothelial growth factor signaling pathway (GO:0038084)2.21763947
157positive regulation of glucose import (GO:0046326)2.16063913
158regulation of cholesterol transport (GO:0032374)2.15880191
159regulation of sterol transport (GO:0032371)2.15880191
160regulation of membrane protein ectodomain proteolysis (GO:0051043)2.15228463
161cellular response to nutrient (GO:0031670)2.14573170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.80890589
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.57672166
3CLOCK_20551151_ChIP-Seq_293T_Human3.73067050
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.57788417
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.42487387
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.04430955
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51942792
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.45643671
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.28554613
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25117900
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08764865
12ZNF263_19887448_ChIP-Seq_K562_Human2.01865233
13* PPARG_19300518_ChIP-PET_3T3-L1_Mouse12.2219161
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93962871
15TBX20_22080862_ChIP-Seq_HEART_Mouse1.78383928
16TBX20_22328084_ChIP-Seq_HEART_Mouse1.78383928
17* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75168317
18MYC_22102868_ChIP-Seq_BL_Human1.74018226
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71786382
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.69953459
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67324763
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65243599
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63946879
24* KDM2B_26808549_Chip-Seq_K562_Human1.63283031
25GATA1_22025678_ChIP-Seq_K562_Human1.60655710
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56640457
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55703664
28* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54529604
29CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54328176
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54002882
31PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.50441435
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50024358
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.48454527
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.46347803
35* SA1_27219007_Chip-Seq_ERYTHROID_Human1.44987565
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44788484
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44417829
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42840351
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.42145164
40* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.40697850
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39968899
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37858742
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35633526
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.35554552
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35443980
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34360982
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33989050
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32147486
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.31790354
50SMC4_20622854_ChIP-Seq_HELA_Human1.31718039
51* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31193924
52* MAF_26560356_Chip-Seq_TH2_Human1.29942037
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.28417941
54* UTX_26944678_Chip-Seq_JUKART_Human1.26262850
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25927518
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.25718343
57LXR_22292898_ChIP-Seq_THP-1_Human1.25660943
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.23283412
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22640173
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22624626
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22084610
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21919923
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19814461
64CREB1_26743006_Chip-Seq_LNCaP_Human1.17383293
65* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17220934
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.17097567
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.16891374
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16565801
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15913290
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13596350
71CTCF_27219007_Chip-Seq_Bcells_Human1.13307319
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.12946782
73TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12906087
74VDR_21846776_ChIP-Seq_THP-1_Human1.12295247
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11989388
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11484978
77* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11451145
78RACK7_27058665_Chip-Seq_MCF-7_Human1.11159190
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.09908831
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09763029
81SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09196771
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06123224
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.06091408
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05833393
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.05609860
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04541901
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03834817
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03668499
89GATA1_19941826_ChIP-Seq_K562_Human1.03217793
90NCOR1_26117541_ChIP-Seq_K562_Human1.03206736
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03051593
92* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02816601
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02782656
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01900664
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01550964
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01002671
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.99728791
98P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98992733
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98742248
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97681293
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96477956
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95073301
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94301130
104ATF3_27146783_Chip-Seq_COLON_Human0.94274797
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94223107
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92784756
107VDR_24763502_ChIP-Seq_THP-1_Human0.92283723
108SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91536662
109* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91203729
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90176984
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89838316
112* MAF_26560356_Chip-Seq_TH1_Human0.88740940
113GATA2_19941826_ChIP-Seq_K562_Human0.88430995
114* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87866487
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86967380
116* KDM2B_26808549_Chip-Seq_DND41_Human0.86562138
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85775731
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85255064
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.83386457
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83201709
121* BCOR_27268052_Chip-Seq_Bcells_Human0.81857645
122SCL_19346495_ChIP-Seq_HPC-7_Human0.80895640
123* BCL6_27268052_Chip-Seq_Bcells_Human0.80554583
124* P68_20966046_ChIP-Seq_HELA_Human0.80430022
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79849061
126TCF7_22412390_ChIP-Seq_EML_Mouse0.78994108
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78770439
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.78154059
129SPI1_20517297_ChIP-Seq_HL60_Human0.77977634
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77002624
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.76428782
132VDR_24787735_ChIP-Seq_THP-1_Human0.76250550
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75986980
134SPI1_23127762_ChIP-Seq_K562_Human0.75888835
135* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75766008
136TP63_22573176_ChIP-Seq_HFKS_Human0.75240369
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74301535
138* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74192352
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73505243
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.73372107
141RUNX_20019798_ChIP-Seq_JUKART_Human0.72493304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.46281292
2MP0005666_abnormal_adipose_tissue4.66849921
3MP0004130_abnormal_muscle_cell4.64394538
4MP0004185_abnormal_adipocyte_glucose3.98877401
5MP0002837_dystrophic_cardiac_calcinosis3.95494881
6MP0005375_adipose_tissue_phenotype3.30540455
7MP0003646_muscle_fatigue2.93565338
8MP0008438_abnormal_cutaneous_collagen2.83493095
9* MP0002971_abnormal_brown_adipose2.62842801
10MP0003191_abnormal_cellular_cholesterol2.40340627
11* MP0010329_abnormal_lipoprotein_level2.31273572
12MP0000751_myopathy2.19524310
13MP0009115_abnormal_fat_cell2.19385089
14MP0000003_abnormal_adipose_tissue2.15645978
15MP0000013_abnormal_adipose_tissue2.12267275
16MP0003303_peritoneal_inflammation1.98656605
17MP0005275_abnormal_skin_tensile1.91341699
18* MP0002118_abnormal_lipid_homeostasis1.89169870
19* MP0005334_abnormal_fat_pad1.88311619
20MP0004084_abnormal_cardiac_muscle1.86934984
21MP0003724_increased_susceptibility_to1.84112378
22MP0005365_abnormal_bile_salt1.79961947
23MP0005330_cardiomyopathy1.75787589
24MP0003705_abnormal_hypodermis_morpholog1.74230211
25MP0006036_abnormal_mitochondrial_physio1.73055028
26* MP0002970_abnormal_white_adipose1.63876708
27MP0003828_pulmonary_edema1.61670741
28MP0002139_abnormal_hepatobiliary_system1.59807448
29MP0004036_abnormal_muscle_relaxation1.59735761
30MP0008775_abnormal_heart_ventricle1.59144928
31* MP0004087_abnormal_muscle_fiber1.58698305
32MP0000750_abnormal_muscle_regeneration1.57903127
33MP0004215_abnormal_myocardial_fiber1.56349189
34MP0005451_abnormal_body_composition1.54220906
35MP0000343_altered_response_to1.50606092
36MP0008260_abnormal_autophagy1.46952077
37MP0000749_muscle_degeneration1.46694946
38* MP0000609_abnormal_liver_physiology1.45932530
39* MP0001544_abnormal_cardiovascular_syste1.43163805
40* MP0005385_cardiovascular_system_phenoty1.43163805
41MP0005360_urolithiasis1.43003714
42MP0004858_abnormal_nervous_system1.42464926
43* MP0005535_abnormal_body_temperature1.41273944
44MP0003186_abnormal_redox_activity1.40625927
45MP0000858_altered_metastatic_potential1.40260689
46MP0002933_joint_inflammation1.39589930
47MP0001661_extended_life_span1.38688292
48MP0005076_abnormal_cell_differentiation1.30783621
49MP0002876_abnormal_thyroid_physiology1.29624434
50MP0009278_abnormal_bone_marrow1.29615225
51* MP0005620_abnormal_muscle_contractility1.26572728
52MP0005448_abnormal_energy_balance1.26220055
53MP0004510_myositis1.25904981
54MP0005332_abnormal_amino_acid1.24571619
55MP0005319_abnormal_enzyme/_coenzyme1.24393836
56MP0003959_abnormal_lean_body1.23299005
57MP0002419_abnormal_innate_immunity1.22851832
58* MP0002972_abnormal_cardiac_muscle1.22526430
59MP0005584_abnormal_enzyme/coenzyme_acti1.21074332
60MP0000759_abnormal_skeletal_muscle1.19768443
61* MP0002078_abnormal_glucose_homeostasis1.19609427
62MP0005503_abnormal_tendon_morphology1.19109012
63MP0009840_abnormal_foam_cell1.18271487
64MP0003172_abnormal_lysosome_physiology1.16347735
65MP0000767_abnormal_smooth_muscle1.15646509
66MP0003091_abnormal_cell_migration1.14599354
67MP0004272_abnormal_basement_membrane1.14594992
68* MP0010630_abnormal_cardiac_muscle1.14511972
69* MP0006138_congestive_heart_failure1.14434763
70MP0005025_abnormal_response_to1.13134068
71MP0003075_altered_response_to1.10948498
72MP0002998_abnormal_bone_remodeling1.09866463
73MP0003566_abnormal_cell_adhesion1.09326141
74MP0002106_abnormal_muscle_physiology1.08829516
75MP0004947_skin_inflammation1.08570418
76MP0009643_abnormal_urine_homeostasis1.07567400
77MP0003453_abnormal_keratinocyte_physiol1.07504318
78MP0005409_darkened_coat_color1.06710738
79MP0002166_altered_tumor_susceptibility1.05098906
80MP0001881_abnormal_mammary_gland1.04022024
81MP0001849_ear_inflammation1.01206338
82MP0002269_muscular_atrophy1.00234907
83MP0001879_abnormal_lymphatic_vessel0.98040972
84MP0001853_heart_inflammation0.97941645
85MP0008961_abnormal_basal_metabolism0.96543766
86MP0005058_abnormal_lysosome_morphology0.96508603
87MP0005000_abnormal_immune_tolerance0.95926205
88MP0002332_abnormal_exercise_endurance0.95851361
89* MP0005452_abnormal_adipose_tissue0.95479360
90MP0009785_altered_susceptibility_to0.95062754
91MP0002254_reproductive_system_inflammat0.93146311
92MP0005387_immune_system_phenotype0.92053679
93MP0001790_abnormal_immune_system0.92053679
94MP0001851_eye_inflammation0.89379054
95MP0002108_abnormal_muscle_morphology0.88938849
96MP0005085_abnormal_gallbladder_physiolo0.88178350
97MP0005390_skeleton_phenotype0.88026277
98MP0002909_abnormal_adrenal_gland0.87797184
99MP0010155_abnormal_intestine_physiology0.86977323
100MP0003868_abnormal_feces_composition0.86245104
101MP0003690_abnormal_glial_cell0.85133957
102MP0005369_muscle_phenotype0.82649334
103MP0005595_abnormal_vascular_smooth0.82329945
104MP0000747_muscle_weakness0.81609297
105MP0005464_abnormal_platelet_physiology0.81396259
106MP0002060_abnormal_skin_morphology0.81161700
107MP0001756_abnormal_urination0.80916723
108MP0005083_abnormal_biliary_tract0.80364211
109MP0004484_altered_response_of0.80143884
110MP0005023_abnormal_wound_healing0.80040585
111MP0009333_abnormal_splenocyte_physiolog0.77532898
112MP0003279_aneurysm0.77494161
113MP0003950_abnormal_plasma_membrane0.77105973
114MP0002796_impaired_skin_barrier0.76673241
115MP0005166_decreased_susceptibility_to0.76386043
116MP0003448_altered_tumor_morphology0.75313271
117MP0002132_abnormal_respiratory_system0.75088603
118MP0003011_delayed_dark_adaptation0.74777604
119MP0000230_abnormal_systemic_arterial0.74737174
120MP0002420_abnormal_adaptive_immunity0.74448228
121MP0001819_abnormal_immune_cell0.74031421
122MP0001835_abnormal_antigen_presentation0.73918464
123MP0003763_abnormal_thymus_physiology0.73553671
124* MP0003221_abnormal_cardiomyocyte_apopto0.70907566
125MP0009763_increased_sensitivity_to0.68798770
126MP0003300_gastrointestinal_ulcer0.68298765
127MP0010368_abnormal_lymphatic_system0.68106359
128MP0005167_abnormal_blood-brain_barrier0.66360852
129MP0002006_tumorigenesis0.64520401
130MP0003045_fibrosis0.63672515
131* MP0000249_abnormal_blood_vessel0.63553523
132MP0004147_increased_porphyrin_level0.63141347
133MP0008875_abnormal_xenobiotic_pharmacok0.62734727
134MP0005164_abnormal_response_to0.62684327
135MP0000685_abnormal_immune_system0.62475853
136MP0001533_abnormal_skeleton_physiology0.62293598
137MP0000598_abnormal_liver_morphology0.61785142
138MP0001958_emphysema0.61617466
139MP0003252_abnormal_bile_duct0.60122818
140MP0005397_hematopoietic_system_phenotyp0.57416156
141MP0001545_abnormal_hematopoietic_system0.57416156
142* MP0003953_abnormal_hormone_level0.57336368
143MP0003436_decreased_susceptibility_to0.56069093

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)5.48269265
2Hyperglycinuria (HP:0003108)5.33514507
3Oligomenorrhea (HP:0000876)5.06670035
4Abnormality of fatty-acid metabolism (HP:0004359)4.64953333
5Rhabdomyolysis (HP:0003201)4.54323428
6Hypoglycemic coma (HP:0001325)4.50999826
7Acanthosis nigricans (HP:0000956)4.36464752
8Abnormality of glycine metabolism (HP:0010895)4.31565602
9Abnormality of serine family amino acid metabolism (HP:0010894)4.31565602
10Dicarboxylic aciduria (HP:0003215)3.99008524
11Abnormality of dicarboxylic acid metabolism (HP:0010995)3.99008524
12Increased connective tissue (HP:0009025)3.88609519
13Protrusio acetabuli (HP:0003179)3.83632811
14Ketoacidosis (HP:0001993)3.83094881
15Exercise-induced myalgia (HP:0003738)3.80779465
16Muscle fiber splitting (HP:0003555)3.67635424
17Ketosis (HP:0001946)3.67055209
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.66153421
19* Hypertriglyceridemia (HP:0002155)3.61589700
20Hyperammonemia (HP:0001987)3.51786367
21Nausea (HP:0002018)3.29060257
22Lipoatrophy (HP:0100578)3.28243485
23Hepatic necrosis (HP:0002605)3.28000036
24Complement deficiency (HP:0004431)3.24556402
25Insulin-resistant diabetes mellitus (HP:0000831)3.22232832
26Ventricular tachycardia (HP:0004756)3.20135987
27Generalized aminoaciduria (HP:0002909)3.19690665
28Hyporeflexia of lower limbs (HP:0002600)3.19106019
29Abnormality of proline metabolism (HP:0010907)3.12518643
30Hydroxyprolinuria (HP:0003080)3.12518643
31Type 1 muscle fiber predominance (HP:0003803)3.09215201
32Sudden death (HP:0001699)3.07750443
33Right ventricular cardiomyopathy (HP:0011663)3.05909703
34Eczematoid dermatitis (HP:0000976)3.01676773
35Hypoalphalipoproteinemia (HP:0003233)3.01234873
36Obstructive sleep apnea (HP:0002870)3.01205642
37Vertebral compression fractures (HP:0002953)2.90694180
38Exercise-induced muscle cramps (HP:0003710)2.83138477
39Muscle stiffness (HP:0003552)2.82846542
40Axonal loss (HP:0003447)2.80609448
41Asymmetric septal hypertrophy (HP:0001670)2.79362771
42Bone cyst (HP:0012062)2.76584163
43Palpitations (HP:0001962)2.76403015
44Hyperglycinemia (HP:0002154)2.72355341
45Cervical subluxation (HP:0003308)2.71395055
46Increased variability in muscle fiber diameter (HP:0003557)2.71346129
47Distal lower limb amyotrophy (HP:0008944)2.69227629
48Distal lower limb muscle weakness (HP:0009053)2.68470300
49Insulin resistance (HP:0000855)2.68220410
50Reduced subcutaneous adipose tissue (HP:0003758)2.64365325
51Colitis (HP:0002583)2.63459213
52Facial diplegia (HP:0001349)2.61909816
53Multiple enchondromatosis (HP:0005701)2.60469227
54* Increased muscle lipid content (HP:0009058)2.60121598
55Hyperlipoproteinemia (HP:0010980)2.57092774
56Xanthomatosis (HP:0000991)2.56651113
57Dysostosis multiplex (HP:0000943)2.55104233
58Abnormality of skeletal muscle fiber size (HP:0012084)2.51768013
59Amyloidosis (HP:0011034)2.47271965
60Dilated cardiomyopathy (HP:0001644)2.47236800
61Calf muscle hypertrophy (HP:0008981)2.45816157
62Stridor (HP:0010307)2.44786074
63Hypercortisolism (HP:0001578)2.43502500
64Hemorrhage of the eye (HP:0011885)2.36662343
65Broad metatarsal (HP:0001783)2.36594863
66Abnormality of complement system (HP:0005339)2.35591648
67Aortic aneurysm (HP:0004942)2.32310482
68Premature rupture of membranes (HP:0001788)2.26653032
69Epidermoid cyst (HP:0200040)2.26593421
70Bulbar palsy (HP:0001283)2.26338260
71Myocardial infarction (HP:0001658)2.26222532
72Centrally nucleated skeletal muscle fibers (HP:0003687)2.26004052
73Prolonged bleeding time (HP:0003010)2.24907079
74Conjunctival hamartoma (HP:0100780)2.24502397
75Mildly elevated creatine phosphokinase (HP:0008180)2.23679935
76Myositis (HP:0100614)2.23161229
77Growth hormone excess (HP:0000845)2.22017999
78Ankle contracture (HP:0006466)2.21632709
79Aneurysm (HP:0002617)2.21555070
80Muscle hypertrophy of the lower extremities (HP:0008968)2.21105229
81Cellulitis (HP:0100658)2.19769148
82Abnormality of polysaccharide metabolism (HP:0011012)2.19708635
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19708635
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19708635
85Lymphangioma (HP:0100764)2.18235108
86Increased IgE level (HP:0003212)2.17873971
87Hepatocellular necrosis (HP:0001404)2.17431112
88Emphysema (HP:0002097)2.17335955
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16654609
90Pancreatitis (HP:0001733)2.16574088
91Thin bony cortex (HP:0002753)2.16523734
92Lethargy (HP:0001254)2.16054579
93Gingivitis (HP:0000230)2.15349922
94Proximal tubulopathy (HP:0000114)2.14946556
95Urinary glycosaminoglycan excretion (HP:0003541)2.14228665
96Mucopolysacchariduria (HP:0008155)2.14228665
97Gastrointestinal inflammation (HP:0004386)2.11355409
98Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11099717
99Dilatation of the ascending aorta (HP:0005111)2.09903745
100Atrioventricular block (HP:0001678)2.08197948
101Atrial fibrillation (HP:0005110)2.07992045
102Vomiting (HP:0002013)2.07565790
103Metabolic acidosis (HP:0001942)2.07360029
104Toxemia of pregnancy (HP:0100603)2.07354510
105Joint stiffness (HP:0001387)2.07194248
106Cerebral edema (HP:0002181)2.06999705
107Abnormality of alanine metabolism (HP:0010916)2.06705711
108Hyperalaninemia (HP:0003348)2.06705711
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06705711
110Myotonia (HP:0002486)2.06316350
111Broad face (HP:0000283)2.06149227
112Skin nodule (HP:0200036)2.05798980
113Bundle branch block (HP:0011710)2.05070857
114Spinal rigidity (HP:0003306)2.04032576
115Prenatal maternal abnormality (HP:0002686)2.03340149
116Abnormal cartilage morphology (HP:0002763)2.03232687
117Pigmentary retinal degeneration (HP:0001146)2.02865327
118Spontaneous hematomas (HP:0007420)2.00879991
119Abnormality of macrophages (HP:0004311)2.00808110
120Neoplasm of head and neck (HP:0012288)2.00780860
121Esophageal neoplasm (HP:0100751)2.00780860
122* Difficulty running (HP:0009046)2.00778234
123Inflammation of the large intestine (HP:0002037)2.00313065
124Abnormality of purine metabolism (HP:0004352)2.00294206
125Gastrointestinal dysmotility (HP:0002579)2.00215600
126Polygenic inheritance (HP:0010982)2.00057743
127Cerebral aneurysm (HP:0004944)1.99985160
128Increased intramyocellular lipid droplets (HP:0012240)1.99305034
129Shallow orbits (HP:0000586)1.97146631
130Tetraparesis (HP:0002273)1.97044336
131Abnormal hemoglobin (HP:0011902)1.96215206
132Methylmalonic aciduria (HP:0012120)1.94800033
133Hyperglycemia (HP:0003074)1.94395707
134Subaortic stenosis (HP:0001682)1.93546309
135Abnormality of the left ventricular outflow tract (HP:0011103)1.93546309
136Polycythemia (HP:0001901)1.93186116
137Lactic acidosis (HP:0003128)1.92272017
138Systemic lupus erythematosus (HP:0002725)1.91632723
139Long foot (HP:0001833)1.91601513
140Hepatosplenomegaly (HP:0001433)1.91299227
141Orchitis (HP:0100796)1.90715433
142Ileus (HP:0002595)1.89136001
143Renal cortical cysts (HP:0000803)1.88526550
144Autoimmune thrombocytopenia (HP:0001973)1.88228988
145Large hands (HP:0001176)1.88207855
146Hypercholesterolemia (HP:0003124)1.86641240
147Recurrent abscess formation (HP:0002722)1.86195188
148Myopathic facies (HP:0002058)1.85953651
149Mitral regurgitation (HP:0001653)1.85349026
150Malnutrition (HP:0004395)1.81957114
151Gastrointestinal stroma tumor (HP:0100723)1.80248776
152Elevated erythrocyte sedimentation rate (HP:0003565)1.79915192
153Biconcave vertebral bodies (HP:0004586)1.79217024
154Blue sclerae (HP:0000592)1.79095702
155Ectopia lentis (HP:0001083)1.76585164
156Recurrent gram-negative bacterial infections (HP:0005420)1.74025659
157Nuclear cataract (HP:0100018)1.72889466
158Wormian bones (HP:0002645)1.72855775
159Vascular tortuosity (HP:0004948)1.71899389
160Gastrointestinal infarctions (HP:0005244)1.69900113
161Fragile skin (HP:0001030)1.69143011
162Foot dorsiflexor weakness (HP:0009027)1.68800457
163Difficulty climbing stairs (HP:0003551)1.68119989
164Peritonitis (HP:0002586)1.68008320
165Segmental peripheral demyelination/remyelination (HP:0003481)1.65669154
166Joint hemorrhage (HP:0005261)1.65629777
167Polar cataract (HP:0010696)1.65623678
168Slender build (HP:0001533)1.65379428
169Abnormality of the nasal mucosa (HP:0000433)1.64948648
170Back pain (HP:0003418)1.63650396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.28227854
2BCKDK4.80073091
3CAMK1D3.98451030
4PDK33.81504429
5PDK43.81504429
6SIK13.15193742
7ERN13.00474452
8CAMK1G2.80317507
9TTN2.77994045
10PRPF4B2.67513417
11LMTK22.56622037
12PDK22.38102823
13PKN22.21988400
14RIPK42.05054526
15RIPK12.03789484
16TIE11.89168144
17TESK11.87647292
18TGFBR21.82434047
19MYLK1.70257782
20PHKG11.64220529
21PHKG21.64220529
22SMG11.63969599
23PRKAA21.62845351
24MST1R1.56564685
25OBSCN1.51050699
26TNK21.50648581
27MAP3K131.44201589
28FGFR41.40890400
29TAOK11.39310549
30MARK21.29023772
31PRKD21.28336266
32MAP2K31.25754676
33PIK3CA1.20565240
34TAOK21.20446288
35EPHA21.19189804
36CDC42BPA1.16355607
37MAP3K11.16259424
38EPHB11.14011809
39FLT31.12979949
40DDR21.09956545
41KDR1.05058951
42NEK91.04359534
43JAK11.03958621
44GRK61.01791609
45PDGFRA1.01305265
46INSRR1.00065809
47BLK0.99391000
48CDK90.99164877
49FGFR30.97544729
50FES0.95221304
51PINK10.94591412
52DMPK0.94227374
53IRAK40.94209019
54PRKAA10.91709930
55TBK10.90428664
56IRAK30.89205014
57HIPK20.88911450
58CDK60.86341187
59MAPKAPK30.84368554
60ILK0.82667991
61MAPK70.81421354
62SIK30.80295365
63TYK20.80232740
64JAK20.79045269
65JAK30.78796112
66PAK40.78203760
67EEF2K0.77724435
68KSR20.77716002
69PDPK10.77480897
70MAP4K10.77044029
71EPHB20.76919073
72PTK60.75830169
73RPS6KA20.73715447
74ARAF0.71099524
75MAPK110.70488799
76BTK0.70286528
77MAP2K10.69580533
78PRKD10.67995972
79LRRK20.67154373
80MAP3K30.67050205
81HCK0.65768467
82MAP3K70.64999897
83PDK10.64898121
84CDK120.64357716
85PTK20.62701315
86MAPK120.60941554
87DYRK1B0.60371811
88TESK20.59121254
89MOS0.58382811
90ZAP700.58265561
91KIT0.58189573
92STK380.57596768
93MAP2K20.57530382
94MAP3K140.56984323
95PTK2B0.54834581
96PRKG20.54297319
97PRKD30.53163070
98PIK3CG0.51604537
99MET0.51053824
100EPHA30.49642641
101CSK0.49595132
102PRKACG0.48964707
103NME20.48773134
104IRAK20.48724709
105MTOR0.48526742
106CDK40.46576678
107MAP2K60.45496579
108PRKCH0.43949906
109ICK0.43510028
110NEK10.43487137
111FGFR20.42930914
112CSF1R0.42089193
113GSK3A0.41531942
114RET0.40365070
115MAPK150.40138497
116MAP3K60.39540674
117PDGFRB0.37147244
118CAMK10.37040597
119TRPM70.36230817
120DAPK30.34715117
121IGF1R0.34640033
122ABL20.34281397
123FRK0.34070534
124MAP3K100.34020968
125BMX0.33882287
126IRAK10.32155482
127IKBKE0.30680894
128FER0.29095634
129LATS10.28714825
130MAPK40.27737063
131WNK40.26703493
132PAK20.26561673
133TGFBR10.25541855
134MAP3K110.24488352
135NLK0.24480456
136RPS6KA60.22954901
137TEC0.21996347
138RPS6KL10.20283764
139RPS6KC10.20283764

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.92641752
2Propanoate metabolism_Homo sapiens_hsa006404.69523713
3Fatty acid degradation_Homo sapiens_hsa000713.82291129
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.79366032
5PPAR signaling pathway_Homo sapiens_hsa033203.68993584
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.65608374
7Fatty acid metabolism_Homo sapiens_hsa012123.62692680
8Fatty acid biosynthesis_Homo sapiens_hsa000613.39460094
9Pyruvate metabolism_Homo sapiens_hsa006202.52640843
10Carbon metabolism_Homo sapiens_hsa012002.43721567
11Other glycan degradation_Homo sapiens_hsa005112.43130543
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42120450
13* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.16518688
14beta-Alanine metabolism_Homo sapiens_hsa004101.93320501
15Adipocytokine signaling pathway_Homo sapiens_hsa049201.83427739
16* Glycerolipid metabolism_Homo sapiens_hsa005611.72320099
17Caffeine metabolism_Homo sapiens_hsa002321.61296533
18Peroxisome_Homo sapiens_hsa041461.60272067
19Fatty acid elongation_Homo sapiens_hsa000621.59741709
20Butanoate metabolism_Homo sapiens_hsa006501.59457632
21Nitrogen metabolism_Homo sapiens_hsa009101.49486577
22Tryptophan metabolism_Homo sapiens_hsa003801.48927620
23Notch signaling pathway_Homo sapiens_hsa043301.48622212
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.47820849
25Fat digestion and absorption_Homo sapiens_hsa049751.45916044
26AMPK signaling pathway_Homo sapiens_hsa041521.42707227
27Malaria_Homo sapiens_hsa051441.39717229
28Insulin resistance_Homo sapiens_hsa049311.29454229
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23794301
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23282249
31Leishmaniasis_Homo sapiens_hsa051401.16377297
32Chronic myeloid leukemia_Homo sapiens_hsa052201.11301416
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11278380
34B cell receptor signaling pathway_Homo sapiens_hsa046621.09083796
35Staphylococcus aureus infection_Homo sapiens_hsa051501.07030408
36Pentose phosphate pathway_Homo sapiens_hsa000301.06421610
37Biosynthesis of amino acids_Homo sapiens_hsa012301.05227488
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04110136
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.04109551
40VEGF signaling pathway_Homo sapiens_hsa043701.02687479
41Phenylalanine metabolism_Homo sapiens_hsa003601.02624567
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02305402
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00936954
44Insulin signaling pathway_Homo sapiens_hsa049100.99270235
45Starch and sucrose metabolism_Homo sapiens_hsa005000.96464698
46Arginine biosynthesis_Homo sapiens_hsa002200.95200573
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94599399
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90010430
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.89164224
50Glucagon signaling pathway_Homo sapiens_hsa049220.88675201
51TNF signaling pathway_Homo sapiens_hsa046680.86717800
52Non-small cell lung cancer_Homo sapiens_hsa052230.83521695
53Hepatitis C_Homo sapiens_hsa051600.81978726
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81812230
55Pertussis_Homo sapiens_hsa051330.81766727
56GnRH signaling pathway_Homo sapiens_hsa049120.79824546
57Lysine degradation_Homo sapiens_hsa003100.77102414
58Tyrosine metabolism_Homo sapiens_hsa003500.76807062
59Pancreatic cancer_Homo sapiens_hsa052120.75363124
60Tuberculosis_Homo sapiens_hsa051520.74788048
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73894547
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73210660
63Platelet activation_Homo sapiens_hsa046110.72145762
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68833425
65Fructose and mannose metabolism_Homo sapiens_hsa000510.67786762
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.67590170
67Complement and coagulation cascades_Homo sapiens_hsa046100.67031092
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66357558
69Renin-angiotensin system_Homo sapiens_hsa046140.64304625
70Chemokine signaling pathway_Homo sapiens_hsa040620.64121384
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63811782
72Parkinsons disease_Homo sapiens_hsa050120.63085294
73Prion diseases_Homo sapiens_hsa050200.62464336
74Renal cell carcinoma_Homo sapiens_hsa052110.61898921
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60589102
76ABC transporters_Homo sapiens_hsa020100.58822760
77Influenza A_Homo sapiens_hsa051640.57601180
78mTOR signaling pathway_Homo sapiens_hsa041500.57316565
79Cardiac muscle contraction_Homo sapiens_hsa042600.56325269
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55609579
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55463769
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.55265653
83Dilated cardiomyopathy_Homo sapiens_hsa054140.55191351
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.54578293
85Ovarian steroidogenesis_Homo sapiens_hsa049130.54255573
86Oxidative phosphorylation_Homo sapiens_hsa001900.53170422
87Sulfur relay system_Homo sapiens_hsa041220.52997676
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52931992
89T cell receptor signaling pathway_Homo sapiens_hsa046600.52916439
90Choline metabolism in cancer_Homo sapiens_hsa052310.51770187
91Endometrial cancer_Homo sapiens_hsa052130.51552826
92Galactose metabolism_Homo sapiens_hsa000520.51491470
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51278948
94Prolactin signaling pathway_Homo sapiens_hsa049170.51196129
95Allograft rejection_Homo sapiens_hsa053300.51112504
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.51046604
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.50780285
98Bladder cancer_Homo sapiens_hsa052190.49341650
99Hematopoietic cell lineage_Homo sapiens_hsa046400.48748262
100Endocytosis_Homo sapiens_hsa041440.48156634
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47337292
102Viral myocarditis_Homo sapiens_hsa054160.46495349
103HTLV-I infection_Homo sapiens_hsa051660.46350899
104FoxO signaling pathway_Homo sapiens_hsa040680.46309502
105Graft-versus-host disease_Homo sapiens_hsa053320.46306291
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46291373
107Estrogen signaling pathway_Homo sapiens_hsa049150.46211039
108Sulfur metabolism_Homo sapiens_hsa009200.45344548
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45062504
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44573482
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44356439
112Autoimmune thyroid disease_Homo sapiens_hsa053200.44247801
113Proteoglycans in cancer_Homo sapiens_hsa052050.43663685
114Vitamin digestion and absorption_Homo sapiens_hsa049770.43306645
115Alzheimers disease_Homo sapiens_hsa050100.43061875
116HIF-1 signaling pathway_Homo sapiens_hsa040660.41256668
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41019915
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40964934
119ECM-receptor interaction_Homo sapiens_hsa045120.39095448
120Vitamin B6 metabolism_Homo sapiens_hsa007500.38206342
121Acute myeloid leukemia_Homo sapiens_hsa052210.38139581
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37147001
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36885395
124Chemical carcinogenesis_Homo sapiens_hsa052040.32259934
125Bile secretion_Homo sapiens_hsa049760.32025075
126Focal adhesion_Homo sapiens_hsa045100.31110620
127Type II diabetes mellitus_Homo sapiens_hsa049300.29218436
128* Metabolic pathways_Homo sapiens_hsa011000.28279645
129Glutathione metabolism_Homo sapiens_hsa004800.28071733
130Protein digestion and absorption_Homo sapiens_hsa049740.27946793
131Toxoplasmosis_Homo sapiens_hsa051450.25518062
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.22656671
133Lysosome_Homo sapiens_hsa041420.22037561
134Huntingtons disease_Homo sapiens_hsa050160.21920637
135Renin secretion_Homo sapiens_hsa049240.21616300
136Histidine metabolism_Homo sapiens_hsa003400.21602138
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19765903
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.19081954
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.18797721
140Amoebiasis_Homo sapiens_hsa051460.17722579
141Osteoclast differentiation_Homo sapiens_hsa043800.15355596
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.15295433
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13871564
144Legionellosis_Homo sapiens_hsa051340.13655026
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.12707117
146Linoleic acid metabolism_Homo sapiens_hsa005910.12688673
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12438821
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.11594144
149Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11117509
150Thyroid cancer_Homo sapiens_hsa052160.11017769
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10599049

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