PNPLA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli (Wilson et al., 2006 [PubMed 16799181]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.55346482
2L-phenylalanine catabolic process (GO:0006559)5.55346482
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.30760781
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.29336242
5L-phenylalanine metabolic process (GO:0006558)5.29336242
6aromatic amino acid family catabolic process (GO:0009074)5.23580005
7tryptophan catabolic process (GO:0006569)4.97500421
8indole-containing compound catabolic process (GO:0042436)4.97500421
9indolalkylamine catabolic process (GO:0046218)4.97500421
10urea cycle (GO:0000050)4.85240068
11urea metabolic process (GO:0019627)4.85240068
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84105894
13alpha-linolenic acid metabolic process (GO:0036109)4.83085863
14tryptophan metabolic process (GO:0006568)4.77996909
15peptidyl-glutamic acid carboxylation (GO:0017187)4.77891752
16protein carboxylation (GO:0018214)4.77891752
17kynurenine metabolic process (GO:0070189)4.73397256
18complement activation, alternative pathway (GO:0006957)4.67407268
19bile acid biosynthetic process (GO:0006699)4.66744941
20high-density lipoprotein particle remodeling (GO:0034375)4.58351378
21mannose metabolic process (GO:0006013)4.51610512
22nitrogen cycle metabolic process (GO:0071941)4.43137930
23regulation of protein activation cascade (GO:2000257)4.40706876
24glyoxylate metabolic process (GO:0046487)4.34745558
25phospholipid efflux (GO:0033700)4.33572056
26regulation of triglyceride catabolic process (GO:0010896)4.29582842
27negative regulation of fibrinolysis (GO:0051918)4.27278976
28reverse cholesterol transport (GO:0043691)4.20186301
29regulation of complement activation (GO:0030449)4.14371499
30sulfur amino acid catabolic process (GO:0000098)4.11614139
31regulation of fibrinolysis (GO:0051917)4.10087130
32regulation of cholesterol esterification (GO:0010872)4.06806273
33phospholipid homeostasis (GO:0055091)4.06544091
34negative regulation of erythrocyte differentiation (GO:0045647)4.06197820
35protein-lipid complex remodeling (GO:0034368)4.04264749
36macromolecular complex remodeling (GO:0034367)4.04264749
37plasma lipoprotein particle remodeling (GO:0034369)4.04264749
38positive regulation of protein kinase C signaling (GO:0090037)4.03081333
39bile acid metabolic process (GO:0008206)4.00795795
40cysteine metabolic process (GO:0006534)3.98812283
41plasma lipoprotein particle clearance (GO:0034381)3.96384541
42plasma lipoprotein particle assembly (GO:0034377)3.86156347
43cholesterol efflux (GO:0033344)3.83224284
44serine family amino acid catabolic process (GO:0009071)3.77955442
45homocysteine metabolic process (GO:0050667)3.74573842
46aromatic amino acid family metabolic process (GO:0009072)3.73910652
47amino-acid betaine metabolic process (GO:0006577)3.73440769
48negative regulation of sterol transport (GO:0032372)3.71356289
49negative regulation of cholesterol transport (GO:0032375)3.71356289
50low-density lipoprotein particle remodeling (GO:0034374)3.61825099
51triglyceride homeostasis (GO:0070328)3.59875150
52acylglycerol homeostasis (GO:0055090)3.59875150
53tyrosine metabolic process (GO:0006570)3.58440506
54endothelial cell chemotaxis (GO:0035767)3.57661121
55protein-lipid complex assembly (GO:0065005)3.55944020
56amine catabolic process (GO:0009310)3.54816511
57cellular biogenic amine catabolic process (GO:0042402)3.54816511
58bile acid and bile salt transport (GO:0015721)3.52971012
59indolalkylamine metabolic process (GO:0006586)3.52902998
60very-low-density lipoprotein particle assembly (GO:0034379)3.51644221
61complement activation, classical pathway (GO:0006958)3.46092480
62negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.45813813
63plasma lipoprotein particle organization (GO:0071827)3.44582753
64imidazole-containing compound metabolic process (GO:0052803)3.44253211
65lysine catabolic process (GO:0006554)3.43596216
66lysine metabolic process (GO:0006553)3.43596216
67alpha-amino acid catabolic process (GO:1901606)3.42379328
68regulation of ARF GTPase activity (GO:0032312)3.40332199
69complement activation (GO:0006956)3.39968798
70positive regulation of triglyceride lipase activity (GO:0061365)3.37894302
71positive regulation of lipoprotein lipase activity (GO:0051006)3.37894302
72protein activation cascade (GO:0072376)3.37493987
73positive regulation of lipid catabolic process (GO:0050996)3.34237824
74ethanol oxidation (GO:0006069)3.32843884
75killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.30480970
76disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.30480970
77protein-lipid complex subunit organization (GO:0071825)3.29722279
78fibrinolysis (GO:0042730)3.29236429
79dicarboxylic acid biosynthetic process (GO:0043650)3.27234587
80insulin-like growth factor receptor signaling pathway (GO:0048009)3.26937460
81cellular glucuronidation (GO:0052695)3.25441653
82acute-phase response (GO:0006953)3.24744242
83cholesterol homeostasis (GO:0042632)3.18817237
84glycine metabolic process (GO:0006544)3.18110456
85blood coagulation, intrinsic pathway (GO:0007597)3.17986303
86positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.16934287
87negative regulation of cell size (GO:0045792)3.15677160
88benzene-containing compound metabolic process (GO:0042537)3.15653251
89aldehyde catabolic process (GO:0046185)3.15251172
90coenzyme catabolic process (GO:0009109)3.15133178
91negative regulation of lipase activity (GO:0060192)3.13756481
92cellular modified amino acid catabolic process (GO:0042219)3.12177682
93sterol homeostasis (GO:0055092)3.11950453
94NAD biosynthetic process (GO:0009435)3.11504777
95cellular amino acid catabolic process (GO:0009063)3.10900800
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10674420
97positive regulation by organism of defense response of other organism involved in symbiotic interact3.10674420
98modulation by symbiont of host immune response (GO:0052553)3.10674420
99positive regulation by symbiont of host defense response (GO:0052509)3.10674420
100modulation by symbiont of host defense response (GO:0052031)3.10674420
101modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10674420
102positive regulation of histone deacetylation (GO:0031065)3.10524547
103regulation of ARF protein signal transduction (GO:0032012)3.09942935
104pyridine nucleotide biosynthetic process (GO:0019363)3.08683145
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.08683145
106cofactor catabolic process (GO:0051187)3.06464013
107lipoprotein metabolic process (GO:0042157)3.05476978
108semaphorin-plexin signaling pathway (GO:0071526)3.05408991
109valine metabolic process (GO:0006573)3.00475403
110cytolysis (GO:0019835)2.99290636
111positive regulation of Rap GTPase activity (GO:0032854)2.98998146
112regulation of interferon-beta biosynthetic process (GO:0045357)2.95629162
113regulation of hydrogen peroxide metabolic process (GO:0010310)2.95422768
114carnitine shuttle (GO:0006853)2.94538528
115regulation of gamma-delta T cell differentiation (GO:0045586)2.85245870
116cell volume homeostasis (GO:0006884)2.77376725
117fatty acid transmembrane transport (GO:1902001)2.64467947
118cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.64273386
119quaternary ammonium group transport (GO:0015697)2.59825692
120histone H3-K9 demethylation (GO:0033169)2.59797707
121regulation of skeletal muscle contraction (GO:0014819)2.57859575
122regulation of gamma-delta T cell activation (GO:0046643)2.57143075
123positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55934503
124peptidyl-tyrosine autophosphorylation (GO:0038083)2.55414719
1252-oxoglutarate metabolic process (GO:0006103)2.54069124
126creatine metabolic process (GO:0006600)2.52630630
127cell-cell junction maintenance (GO:0045217)2.51857433
128germinal center formation (GO:0002467)2.51812673
129activation of JUN kinase activity (GO:0007257)2.50852187
130thymic T cell selection (GO:0045061)2.49288316
131phospholipid scrambling (GO:0017121)2.47050276
132positive regulation of cholesterol efflux (GO:0010875)2.45347761
133histone H3 deacetylation (GO:0070932)2.44736885
134regulation of synapse maturation (GO:0090128)2.37720683
135negative regulation of granulocyte differentiation (GO:0030853)2.37233617
136response to manganese ion (GO:0010042)2.37093419
137activation of protein kinase A activity (GO:0034199)2.36179711
138regulation of Rap GTPase activity (GO:0032317)2.35992829
139cytoskeletal anchoring at plasma membrane (GO:0007016)2.35503851
140positive regulation of protein deacetylation (GO:0090312)2.34822079
141positive thymic T cell selection (GO:0045059)2.33380684
142histone H4 deacetylation (GO:0070933)2.32504197
143vascular endothelial growth factor signaling pathway (GO:0038084)2.31756971
144carnitine transmembrane transport (GO:1902603)2.31336990
145synaptic vesicle docking involved in exocytosis (GO:0016081)2.31031977
146positive regulation of synapse maturation (GO:0090129)2.28935853
147cAMP biosynthetic process (GO:0006171)2.26213531
148positive regulation of receptor recycling (GO:0001921)2.24609561
149regulation of protein kinase C signaling (GO:0090036)2.22784432
150adherens junction assembly (GO:0034333)2.20893690
151positive regulation of triglyceride metabolic process (GO:0090208)2.20168702
152phosphatidylglycerol biosynthetic process (GO:0006655)2.18855823
153regulation of ruffle assembly (GO:1900027)2.18514938
154urinary tract smooth muscle contraction (GO:0014848)2.17953971
155amino-acid betaine transport (GO:0015838)2.17714981
156carnitine transport (GO:0015879)2.17714981
157diacylglycerol metabolic process (GO:0046339)2.16708072
158Rap protein signal transduction (GO:0032486)2.14789567
159regulation of T-helper 2 cell differentiation (GO:0045628)2.14018667
160focal adhesion assembly (GO:0048041)2.13341389
161cell-substrate adherens junction assembly (GO:0007045)2.13341389
162positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.12482177
163skeletal muscle adaptation (GO:0043501)2.12033563
164negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.11803792
165regulation of fatty acid oxidation (GO:0046320)2.10219870
166regulation of p38MAPK cascade (GO:1900744)2.09174407
167negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.07420662
168Rho protein signal transduction (GO:0007266)2.07389460
169white fat cell differentiation (GO:0050872)2.06602441
170epithelial cell differentiation involved in prostate gland development (GO:0060742)2.05090990
171regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.04681588
172negative regulation of fatty acid transport (GO:2000192)2.04239510
173regulation of cytokine production involved in inflammatory response (GO:1900015)2.02844495
174macroautophagy (GO:0016236)2.02316778
175ovulation (GO:0030728)2.01860867
176regulation of histone H3-K27 methylation (GO:0061085)2.01366565
177neuronal ion channel clustering (GO:0045161)2.00305631
178T cell selection (GO:0045058)2.00057030
179regulation of glucose import in response to insulin stimulus (GO:2001273)1.99659880
180regulation of fatty acid beta-oxidation (GO:0031998)1.99568670
181positive regulation of fatty acid beta-oxidation (GO:0032000)1.98307802
182atrioventricular valve morphogenesis (GO:0003181)1.98307725
183regulation of apoptotic cell clearance (GO:2000425)1.98018474
184chondroitin sulfate catabolic process (GO:0030207)1.97325834
185cell junction maintenance (GO:0034331)1.95904824
186positive regulation of type I interferon-mediated signaling pathway (GO:0060340)1.95099997
187regulation of histone deacetylation (GO:0031063)1.94177960
188activation of MAPKKK activity (GO:0000185)1.94123846
189peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)1.93032349
190regulation of cholesterol metabolic process (GO:0090181)1.92619619
191positive regulation of cholesterol transport (GO:0032376)1.92024819
192positive regulation of sterol transport (GO:0032373)1.92024819
193response to stimulus involved in regulation of muscle adaptation (GO:0014874)1.90990466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.30741985
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.99749312
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.32634562
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.14741170
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.77473266
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.13850716
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.88420494
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.74395254
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.34189792
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.16429067
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.12103069
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.85288235
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.81240930
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67996255
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.65326334
16* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.64610929
17* ESR2_21235772_ChIP-Seq_MCF-7_Human2.52291254
18* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.43936447
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42708139
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36970518
21* DROSHA_22980978_ChIP-Seq_HELA_Human2.35968272
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35208992
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33533821
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.25567401
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21143555
26SCL_19346495_ChIP-Seq_HPC-7_Human2.21037261
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19003155
28KDM2B_26808549_Chip-Seq_DND41_Human2.14787638
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08855910
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08115605
31GATA1_22025678_ChIP-Seq_K562_Human2.06506842
32RACK7_27058665_Chip-Seq_MCF-7_Human2.01423225
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.99928575
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98116196
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.95661276
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95348527
37KDM2B_26808549_Chip-Seq_K562_Human1.94452437
38* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83806336
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79197905
40P68_20966046_ChIP-Seq_HELA_Human1.78234007
41* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76566987
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.74464362
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.74059853
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73498699
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72450369
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71835676
47SMC4_20622854_ChIP-Seq_HELA_Human1.68185716
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66877112
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61770260
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59942249
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.59652593
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59625298
53CTCF_27219007_Chip-Seq_Bcells_Human1.59323198
54CREB1_26743006_Chip-Seq_LNCaP_Human1.58437888
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56321243
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52039135
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51698428
58* RUNX1_27514584_Chip-Seq_MCF-7_Human1.50280738
59* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48154491
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47744860
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44236699
62* ESR1_21235772_ChIP-Seq_MCF-7_Human1.41550740
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40570495
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.40107884
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.39774619
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39371173
67RUNX_20019798_ChIP-Seq_JUKART_Human1.36389153
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34258798
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33333589
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.32405012
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32330647
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31171708
73BCOR_27268052_Chip-Seq_Bcells_Human1.29948114
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29336961
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.27780365
76* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27560038
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24404608
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23881854
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23815102
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.23148266
81BCL6_27268052_Chip-Seq_Bcells_Human1.23118110
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23095509
83TP63_22573176_ChIP-Seq_HFKS_Human1.22293317
84SPI1_23547873_ChIP-Seq_NB4_Human1.21263731
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21163310
86* FOXA2_19822575_ChIP-Seq_HepG2_Human1.21154705
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20931528
88ZNF263_19887448_ChIP-Seq_K562_Human1.20853710
89MAF_26560356_Chip-Seq_TH1_Human1.19293207
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18806195
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18793024
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18769929
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18657458
94* RUNX1_22412390_ChIP-Seq_EML_Mouse1.18547978
95PU_27001747_Chip-Seq_BMDM_Mouse1.17413761
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16728095
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16377119
98MYB_26560356_Chip-Seq_TH1_Human1.16212769
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15528370
100* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12420386
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11043569
102VDR_24763502_ChIP-Seq_THP-1_Human1.09916943
103VDR_21846776_ChIP-Seq_THP-1_Human1.09708286
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08866559
105TP63_17297297_ChIP-ChIP_HaCaT_Human1.08821832
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08775342
107TBX20_22328084_ChIP-Seq_HEART_Mouse1.08761158
108TBX20_22080862_ChIP-Seq_HEART_Mouse1.08761158
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.08701865
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07556355
111TET1_21490601_ChIP-Seq_MESCs_Mouse1.07279283
112MYB_26560356_Chip-Seq_TH2_Human1.06985644
113OCT4_19829295_ChIP-Seq_ESCs_Human1.06795678
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05040299
115P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04818290
116SA1_27219007_Chip-Seq_Bcells_Human1.03281978
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02862606
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02812272
119* SPI1_23127762_ChIP-Seq_K562_Human1.02628747
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02298687
121HNF4A_19822575_ChIP-Seq_HepG2_Human1.01833178
122GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01114750
123SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01101499
124SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00341061
125RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99922400
126RARB_27405468_Chip-Seq_BRAIN_Mouse0.99761819
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99534837
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98224219
129VDR_24787735_ChIP-Seq_THP-1_Human0.98190744
130MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97828412
131TCF7_22412390_ChIP-Seq_EML_Mouse0.95150434
132E2F1_20622854_ChIP-Seq_HELA_Human0.95038678
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94689425
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.94330766
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94221280
136CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93884020
137GATA2_19941826_ChIP-Seq_K562_Human0.93847092
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93406026
139FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91985710
140GATA1_19941826_ChIP-Seq_K562_Human0.91698709
141UTX_26944678_Chip-Seq_JUKART_Human0.91032895
142CLOCK_20551151_ChIP-Seq_293T_Human0.90484322
143SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89968327
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89911296
145PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86417841
146EGR1_19374776_ChIP-ChIP_THP-1_Human0.85949776
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83515856
148GATA3_26560356_Chip-Seq_TH2_Human0.83255463
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82719036
150GATA3_27048872_Chip-Seq_THYMUS_Human0.81304831
151SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75682201
152MYC_22102868_ChIP-Seq_BL_Human0.75041147
153HTT_18923047_ChIP-ChIP_STHdh_Human0.73967452
154SPI1_20517297_ChIP-Seq_HL60_Human0.72300028
155MAF_26560356_Chip-Seq_TH2_Human0.71438747
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71246872
157LXR_22292898_ChIP-Seq_THP-1_Human0.70812888
158SOX2_27498859_Chip-Seq_STOMACH_Mouse0.68962731
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.68257799
160ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.67613068
161GATA4_25053715_ChIP-Seq_YYC3_Human0.65561558
162TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64936360
163VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.63567321
164CEBPB_22108803_ChIP-Seq_LS180_Human0.62964841
165TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61406645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.01557084
2MP0005360_urolithiasis5.30623122
3MP0005365_abnormal_bile_salt4.62809456
4MP0005085_abnormal_gallbladder_physiolo4.52129951
5MP0009840_abnormal_foam_cell3.62507301
6MP0008875_abnormal_xenobiotic_pharmacok3.49524848
7MP0003191_abnormal_cellular_cholesterol3.07964516
8MP0003252_abnormal_bile_duct3.03550952
9MP0000751_myopathy2.96344729
10MP0010329_abnormal_lipoprotein_level2.88607924
11MP0003806_abnormal_nucleotide_metabolis2.87243703
12MP0000013_abnormal_adipose_tissue2.54589960
13MP0005409_darkened_coat_color2.38261927
14MP0001835_abnormal_antigen_presentation2.35299133
15MP0005666_abnormal_adipose_tissue2.29940213
16MP0005058_abnormal_lysosome_morphology2.28033624
17MP0005083_abnormal_biliary_tract2.27586002
18MP0005375_adipose_tissue_phenotype2.14494627
19MP0003436_decreased_susceptibility_to2.14410507
20MP0000609_abnormal_liver_physiology2.06295469
21MP0004036_abnormal_muscle_relaxation2.06007555
22MP0003879_abnormal_hair_cell2.00630951
23MP0002933_joint_inflammation1.98572928
24MP0005464_abnormal_platelet_physiology1.97664617
25MP0005332_abnormal_amino_acid1.88667006
26MP0000003_abnormal_adipose_tissue1.86356122
27MP0001666_abnormal_nutrient_absorption1.85237644
28MP0002419_abnormal_innate_immunity1.82352365
29MP0006082_CNS_inflammation1.80279496
30MP0002138_abnormal_hepatobiliary_system1.79884946
31MP0003279_aneurysm1.77614555
32MP0003195_calcinosis1.74074377
33MP0002118_abnormal_lipid_homeostasis1.73181190
34MP0008260_abnormal_autophagy1.72671426
35MP0006138_congestive_heart_failure1.70337099
36MP0002249_abnormal_larynx_morphology1.67548425
37MP0005167_abnormal_blood-brain_barrier1.64470352
38MP0003172_abnormal_lysosome_physiology1.62454778
39MP0002822_catalepsy1.60722158
40MP0004084_abnormal_cardiac_muscle1.60284731
41MP0005319_abnormal_enzyme/_coenzyme1.58092589
42MP0001849_ear_inflammation1.57401875
43MP0003656_abnormal_erythrocyte_physiolo1.57314417
44MP0001958_emphysema1.57261524
45MP0008469_abnormal_protein_level1.54902337
46MP0005025_abnormal_response_to1.53924379
47MP0009785_altered_susceptibility_to1.53261039
48MP0003724_increased_susceptibility_to1.52557360
49MP0004019_abnormal_vitamin_homeostasis1.49894426
50MP0009764_decreased_sensitivity_to1.48520816
51MP0009384_cardiac_valve_regurgitation1.48426074
52MP0001800_abnormal_humoral_immune1.48375432
53MP0000685_abnormal_immune_system1.48239707
54MP0005535_abnormal_body_temperature1.43750236
55MP0005670_abnormal_white_adipose1.41431016
56MP0001853_heart_inflammation1.41194540
57MP0003045_fibrosis1.40553855
58MP0003868_abnormal_feces_composition1.40041809
59MP0005387_immune_system_phenotype1.39086592
60MP0001790_abnormal_immune_system1.39086592
61MP0001764_abnormal_homeostasis1.38616860
62MP0005584_abnormal_enzyme/coenzyme_acti1.36067882
63MP0004145_abnormal_muscle_electrophysio1.35848998
64MP0002452_abnormal_antigen_presenting1.32942438
65MP0005000_abnormal_immune_tolerance1.32901170
66MP0004858_abnormal_nervous_system1.31236159
67MP0002723_abnormal_immune_serum1.31148110
68MP0009763_increased_sensitivity_to1.31031479
69MP0001348_abnormal_lacrimal_gland1.26522293
70MP0000678_abnormal_parathyroid_gland1.26191740
71MP0005671_abnormal_response_to1.25605861
72MP0000569_abnormal_digit_pigmentation1.25478777
73MP0003303_peritoneal_inflammation1.22713283
74MP0000604_amyloidosis1.21904351
75MP0003690_abnormal_glial_cell1.20918014
76MP0000598_abnormal_liver_morphology1.20427144
77MP0000747_muscle_weakness1.19784418
78MP0004185_abnormal_adipocyte_glucose1.18595835
79MP0005503_abnormal_tendon_morphology1.18571453
80MP0001845_abnormal_inflammatory_respons1.18470653
81MP0005330_cardiomyopathy1.17745522
82MP0005451_abnormal_body_composition1.17557180
83MP0003183_abnormal_peptide_metabolism1.15435748
84MP0004087_abnormal_muscle_fiber1.14891223
85MP0002148_abnormal_hypersensitivity_rea1.13098900
86MP0003646_muscle_fatigue1.12311021
87MP0000767_abnormal_smooth_muscle1.12111531
88MP0003300_gastrointestinal_ulcer1.11540494
89MP0004859_abnormal_synaptic_plasticity1.10806074
90MP0003186_abnormal_redox_activity1.09385394
91MP0005076_abnormal_cell_differentiation1.09287212
92MP0001819_abnormal_immune_cell1.08799290
93MP0002420_abnormal_adaptive_immunity1.08529525
94MP0002254_reproductive_system_inflammat1.07930571
95MP0002998_abnormal_bone_remodeling1.06264896
96MP0002108_abnormal_muscle_morphology1.06113021
97MP0000749_muscle_degeneration1.05926737
98MP0003453_abnormal_keratinocyte_physiol1.05003258
99MP0009643_abnormal_urine_homeostasis1.04931673
100MP0004947_skin_inflammation1.04927244
101MP0005647_abnormal_sex_gland1.04741150
102MP0003011_delayed_dark_adaptation1.04515882
103MP0004130_abnormal_muscle_cell1.03692252
104MP0001502_abnormal_circadian_rhythm1.03177586
105MP0000759_abnormal_skeletal_muscle0.98518696
106MP0005595_abnormal_vascular_smooth0.98167126
107MP0009697_abnormal_copulation0.96807689
108MP0003075_altered_response_to0.95524059
109MP0000689_abnormal_spleen_morphology0.95112596
110MP0004510_myositis0.94304231
111MP0001533_abnormal_skeleton_physiology0.93790296
112MP0003091_abnormal_cell_migration0.92556793
113MP0009780_abnormal_chondrocyte_physiolo0.92512759
114MP0002405_respiratory_system_inflammati0.92160837
115MP0008961_abnormal_basal_metabolism0.91762985
116MP0005620_abnormal_muscle_contractility0.91335194
117MP0001501_abnormal_sleep_pattern0.89591102
118MP0005075_abnormal_melanosome_morpholog0.88558810
119MP0009765_abnormal_xenobiotic_induced0.87819980
120MP0010368_abnormal_lymphatic_system0.87486976
121MP0000716_abnormal_immune_system0.87410197
122MP0004043_abnormal_pH_regulation0.86716289
123MP0009642_abnormal_blood_homeostasis0.86704672
124MP0005448_abnormal_energy_balance0.85819996
125MP0001765_abnormal_ion_homeostasis0.85209325
126MP0002971_abnormal_brown_adipose0.84768823
127MP0009278_abnormal_bone_marrow0.84306764
128MP0002166_altered_tumor_susceptibility0.83530173
129MP0001873_stomach_inflammation0.83285325
130MP0008874_decreased_physiological_sensi0.82848062
131MP0005397_hematopoietic_system_phenotyp0.82596267
132MP0001545_abnormal_hematopoietic_system0.82596267
133MP0000465_gastrointestinal_hemorrhage0.80974860
134MP0005334_abnormal_fat_pad0.80481575
135MP0010155_abnormal_intestine_physiology0.80423347
136MP0002970_abnormal_white_adipose0.80364237
137MP0000733_abnormal_muscle_development0.80184713
138MP0005166_decreased_susceptibility_to0.80078338
139MP0002106_abnormal_muscle_physiology0.79442769
140MP0002398_abnormal_bone_marrow0.78973915
141MP0002332_abnormal_exercise_endurance0.78735404
142MP0005369_muscle_phenotype0.78554578
143MP0002396_abnormal_hematopoietic_system0.76218238
144MP0010630_abnormal_cardiac_muscle0.75152136
145MP0003763_abnormal_thymus_physiology0.75031116
146MP0002722_abnormal_immune_system0.74963444
147MP0002928_abnormal_bile_duct0.74547855
148MP0005174_abnormal_tail_pigmentation0.74290902
149MP0002429_abnormal_blood_cell0.74021155
150MP0000343_altered_response_to0.73422366
151MP0002269_muscular_atrophy0.73312225
152MP0002796_impaired_skin_barrier0.71357697
153MP0003705_abnormal_hypodermis_morpholog0.69022237
154MP0003329_amyloid_beta_deposits0.66856137
155MP0004381_abnormal_hair_follicle0.66116224
156MP0000249_abnormal_blood_vessel0.65447496
157MP0002136_abnormal_kidney_physiology0.65248410
158MP0009115_abnormal_fat_cell0.65199254
159MP0000371_diluted_coat_color0.64954167
160MP0008873_increased_physiological_sensi0.61266590
161MP0005376_homeostasis/metabolism_phenot0.61075639
162MP0005636_abnormal_mineral_homeostasis0.60778302

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.94008249
2Deep venous thrombosis (HP:0002625)5.47128980
3Intrahepatic cholestasis (HP:0001406)5.41383844
4Complement deficiency (HP:0004431)5.28973501
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.19412936
6Prolonged partial thromboplastin time (HP:0003645)5.15903330
7Xanthomatosis (HP:0000991)4.98496768
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.94499527
9Joint hemorrhage (HP:0005261)4.90858651
10Recurrent gram-negative bacterial infections (HP:0005420)4.67679382
11Hyperlipoproteinemia (HP:0010980)4.45997255
12Hypobetalipoproteinemia (HP:0003563)4.42828804
13Systemic lupus erythematosus (HP:0002725)4.34660109
14Abnormality of complement system (HP:0005339)4.02772825
15J-shaped sella turcica (HP:0002680)3.90744292
16Broad face (HP:0000283)3.81296745
17Hypolipoproteinemia (HP:0010981)3.64910656
18Abnormality of the common coagulation pathway (HP:0010990)3.59727719
19Nuclear cataract (HP:0100018)3.55499905
20Hypoalphalipoproteinemia (HP:0003233)3.53542606
21Myocardial infarction (HP:0001658)3.50412398
22Epidermoid cyst (HP:0200040)3.49097277
23Recurrent bacterial skin infections (HP:0005406)3.47786418
24Cervical subluxation (HP:0003308)3.47252169
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.46872118
26Hypercholesterolemia (HP:0003124)3.45890839
27Hyperammonemia (HP:0001987)3.43808572
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.42760899
29Cerebral aneurysm (HP:0004944)3.42710333
30Abnormality of methionine metabolism (HP:0010901)3.36031129
31Stridor (HP:0010307)3.35564168
32Glomerulonephritis (HP:0000099)3.35261382
33Increased connective tissue (HP:0009025)3.34894054
34Lymphangioma (HP:0100764)3.32502645
35Exercise-induced myalgia (HP:0003738)3.29911256
36Recurrent abscess formation (HP:0002722)3.27936355
37Gingival bleeding (HP:0000225)3.27559468
38Eczematoid dermatitis (HP:0000976)3.23038322
39Abnormality of pyrimidine metabolism (HP:0004353)3.18179856
40Ketosis (HP:0001946)3.16556115
41Fat malabsorption (HP:0002630)3.14033486
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.13847326
43Asymmetric septal hypertrophy (HP:0001670)3.08616322
44Abnormality of glutamine family amino acid metabolism (HP:0010902)3.07728263
45Thin bony cortex (HP:0002753)3.05268366
46Abnormality of the intrinsic pathway (HP:0010989)3.01565876
47Aortic regurgitation (HP:0001659)3.00769391
48Neoplasm of the heart (HP:0100544)2.89290441
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.88849879
50Muscle fiber splitting (HP:0003555)2.86514757
51Vacuolated lymphocytes (HP:0001922)2.86156740
52Conjugated hyperbilirubinemia (HP:0002908)2.80868022
53Amyloidosis (HP:0011034)2.80534249
54Abnormality of fatty-acid metabolism (HP:0004359)2.80331773
55Hyperglycinemia (HP:0002154)2.79140150
56Type 1 muscle fiber predominance (HP:0003803)2.78209374
57Bundle branch block (HP:0011710)2.70452030
58Menorrhagia (HP:0000132)2.68899335
59Hyperglycinuria (HP:0003108)2.65607806
60Recurrent skin infections (HP:0001581)2.64019754
61Joint stiffness (HP:0001387)2.60393513
62Epistaxis (HP:0000421)2.58559872
63Hypoglycemic coma (HP:0001325)2.56684754
64Abnormality of serine family amino acid metabolism (HP:0010894)2.55156729
65Abnormality of glycine metabolism (HP:0010895)2.55156729
66Axonal loss (HP:0003447)2.54371485
67Hyperbilirubinemia (HP:0002904)2.53915290
68Increased variability in muscle fiber diameter (HP:0003557)2.53225252
69Upper motor neuron abnormality (HP:0002127)2.52927615
70Steatorrhea (HP:0002570)2.52462416
71Autoimmune thrombocytopenia (HP:0001973)2.51430667
72Abnormality of nucleobase metabolism (HP:0010932)2.51023089
73Myopathic facies (HP:0002058)2.48134795
74Deformed sella turcica (HP:0002681)2.45427924
75Distal lower limb muscle weakness (HP:0009053)2.42752183
76Abnormality of the fingertips (HP:0001211)2.41702650
77Aortic aneurysm (HP:0004942)2.41433722
78Malnutrition (HP:0004395)2.40831364
79Increased cerebral lipofuscin (HP:0011813)2.39507823
80Distal lower limb amyotrophy (HP:0008944)2.38708783
81Nephritis (HP:0000123)2.35237045
82Abnormality of skeletal muscle fiber size (HP:0012084)2.33459874
83Bulbar palsy (HP:0001283)2.33444701
84Aneurysm (HP:0002617)2.33339776
85Centrally nucleated skeletal muscle fibers (HP:0003687)2.32210300
86Sleep apnea (HP:0010535)2.28817160
87Mitral stenosis (HP:0001718)2.27891115
88Broad metatarsal (HP:0001783)2.26951224
89Bronchomalacia (HP:0002780)2.26928042
90Emphysema (HP:0002097)2.25705026
91Abnormal atrioventricular conduction (HP:0005150)2.25423872
92Spinal canal stenosis (HP:0003416)2.25086433
93Difficulty running (HP:0009046)2.24667896
94Thrombophlebitis (HP:0004418)2.24437824
95Impaired platelet aggregation (HP:0003540)2.23576682
96Abnormal platelet function (HP:0011869)2.23576682
97Visceral angiomatosis (HP:0100761)2.23074593
98Hepatocellular carcinoma (HP:0001402)2.22119581
99Hypochromic microcytic anemia (HP:0004840)2.22075301
100Easy fatigability (HP:0003388)2.21901929
101Hyporeflexia of lower limbs (HP:0002600)2.19022987
102Round ear (HP:0100830)2.19013033
103Heart block (HP:0012722)2.18244096
104Abnormality of iron homeostasis (HP:0011031)2.18124345
105Increased neuronal autofluorescent lipopigment (HP:0002074)2.17966798
106Abnormality of purine metabolism (HP:0004352)2.17444706
107EMG: neuropathic changes (HP:0003445)2.16404794
108Spontaneous abortion (HP:0005268)2.14640728
109Periodontitis (HP:0000704)2.14388986
110Neurofibrillary tangles (HP:0002185)2.13446181
111Gingivitis (HP:0000230)2.12656479
112Abnormality of macrophages (HP:0004311)2.12433838
113Esophageal varix (HP:0002040)2.12321784
114Hemorrhage of the eye (HP:0011885)2.11733401
115Skin nodule (HP:0200036)2.11688965
116Abnormality of serum amino acid levels (HP:0003112)2.10631124
117Recurrent fungal infections (HP:0002841)2.09466137
118Elevated erythrocyte sedimentation rate (HP:0003565)2.09219714
119Sensorimotor neuropathy (HP:0007141)2.09035478
120Vascular calcification (HP:0004934)2.08541638
121Pulmonary embolism (HP:0002204)2.07326143
122Mildly elevated creatine phosphokinase (HP:0008180)2.06731239
123Cerebral palsy (HP:0100021)2.05507440
124Shallow orbits (HP:0000586)2.05431401
125Prolonged bleeding time (HP:0003010)2.04046812
126Papilledema (HP:0001085)2.02684389
127Supranuclear gaze palsy (HP:0000605)2.02502009
128Gastrointestinal inflammation (HP:0004386)2.02206026
129Prolonged QT interval (HP:0001657)2.02147431
130Acanthocytosis (HP:0001927)2.01572841
131Hemangiomatosis (HP:0007461)1.99934727
132Dysostosis multiplex (HP:0000943)1.99371119
133Colitis (HP:0002583)1.98576964
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97109497
135Dicarboxylic aciduria (HP:0003215)1.97109497
136Metabolic acidosis (HP:0001942)1.96449390
137Ulnar deviation of the wrist (HP:0003049)1.96312262
138Delayed CNS myelination (HP:0002188)1.96183099
139Pancreatitis (HP:0001733)1.95709242
140Abnormality of transition element cation homeostasis (HP:0011030)1.95699922
141Biconcave vertebral bodies (HP:0004586)1.95681301
142Hypertriglyceridemia (HP:0002155)1.95201161
143Inflammation of the large intestine (HP:0002037)1.92906808
144Spastic diplegia (HP:0001264)1.92807957
145Urticaria (HP:0001025)1.92569634
146Abnormality of lateral ventricle (HP:0030047)1.91834565
147Spontaneous hematomas (HP:0007420)1.90629971
148Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90487109
149Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90487109
150Abnormality of polysaccharide metabolism (HP:0011012)1.90487109
151Muscle fiber inclusion bodies (HP:0100299)1.90082149
152Ketoacidosis (HP:0001993)1.89734533
153Cholelithiasis (HP:0001081)1.89515000
154Increased serum ferritin (HP:0003281)1.89474385
155Urinary glycosaminoglycan excretion (HP:0003541)1.88447125
156Mucopolysacchariduria (HP:0008155)1.88447125
157Poikilocytosis (HP:0004447)1.88436458
158Purpura (HP:0000979)1.88258668
159Mitral regurgitation (HP:0001653)1.87616396
160Flat acetabular roof (HP:0003180)1.85213357
161Difficulty climbing stairs (HP:0003551)1.81718522
162Increased IgE level (HP:0003212)1.80508050
163Atelectasis (HP:0100750)1.80024597
164Distal upper limb amyotrophy (HP:0007149)1.77900784
165Upper limb amyotrophy (HP:0009129)1.77900784
166Flared iliac wings (HP:0002869)1.77776355
167Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.77231643
168Stroke (HP:0001297)1.77069484
169Sudden death (HP:0001699)1.75380264
170Ankle clonus (HP:0011448)1.75007552
171Nemaline bodies (HP:0003798)1.74855933
172Onion bulb formation (HP:0003383)1.73717918
173Metaphyseal cupping (HP:0003021)1.71657956
174Oligomenorrhea (HP:0000876)1.71058787
175Ventricular arrhythmia (HP:0004308)1.69765809
176Thoracic kyphosis (HP:0002942)1.69071495
177Hypoplasia of the odontoid process (HP:0003311)1.67853565
178Hyperacusis (HP:0010780)1.67338373
179Cerebral inclusion bodies (HP:0100314)1.66471924
180Syncope (HP:0001279)1.66261406
181Spinal rigidity (HP:0003306)1.65220443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.30125160
2ERN13.21805244
3BCKDK3.15979590
4TNK23.05551597
5TAOK33.03831326
6TYK22.95260877
7TGFBR22.74604536
8MAP3K142.67468217
9FGFR42.58035745
10IRAK32.43035512
11KIT2.41714486
12TBK12.34565848
13SIK12.26737133
14MARK22.16164594
15MAP3K62.08439372
16CSF1R2.03898558
17BLK1.94933733
18IRAK41.89870923
19TXK1.87383397
20IKBKE1.82810612
21CDC42BPA1.82174646
22MAP2K61.80244309
23JAK11.79232641
24FLT31.72869765
25MAP2K31.72181122
26PKN21.70539777
27CAMK1D1.63531992
28PRPF4B1.62938348
29ZAP701.61621400
30PRKD21.54774693
31RIPK41.54553684
32JAK31.51884892
33NEK91.48359195
34TRIB31.46807053
35IKBKB1.44950737
36BTK1.43523049
37MAP3K131.42408385
38CSK1.40739790
39NTRK31.40369842
40JAK21.35976069
41EPHB11.33028341
42PRKD31.32199073
43MAPK111.30555174
44PIK3CG1.30025449
45HCK1.26243494
46GRK61.21622796
47SYK1.21389535
48TEC1.21234001
49PTK61.17774415
50RPS6KA21.16068735
51TAOK11.15413687
52ITK1.14411266
53INSRR1.13653565
54CAMK1G1.07913906
55STK101.07498048
56TESK11.06578988
57HIPK21.03883547
58MAP3K101.03331628
59CAMKK11.03129090
60OBSCN1.00734924
61MUSK1.00037153
62BMX0.99782940
63LYN0.98234879
64LCK0.95308814
65MAPKAPK30.94068171
66TTN0.92492564
67MAPK150.91973430
68CDK60.91936353
69MAPK120.91472428
70PRKAA20.91390256
71FGFR30.89703881
72AKT30.89702115
73MAP3K10.86358039
74CHUK0.86100514
75MAP3K70.85676551
76RPS6KC10.84848176
77RPS6KL10.84848176
78CAMK10.84026185
79FES0.82267261
80PHKG20.79586913
81PHKG10.79586913
82PIM10.77546544
83NME10.77362908
84MAPK70.76168694
85MAPK40.73951386
86DMPK0.73423781
87ERBB40.73251329
88MYLK0.72496738
89EEF2K0.72356132
90MAP3K30.72237417
91STK380.71425826
92TRPM70.69529803
93PRKAA10.68685426
94KDR0.68324214
95PDGFRA0.68154783
96DDR20.66465981
97SMG10.66067470
98SIK20.64868381
99PRKD10.64218767
100MST1R0.63338562
101PTK2B0.61930275
102ABL20.60821126
103CDK120.60197595
104PDK10.59087133
105RIPK10.58829277
106PRKCH0.58130210
107PDGFRB0.56315331
108EGFR0.55831154
109CDK40.55711933
110SGK2230.55414554
111SGK4940.55414554
112GRK70.53694412
113SGK30.52822440
114EPHA20.52735796
115PRKCQ0.51505756
116SGK20.51395830
117RET0.50871612
118ABL10.49912585
119GRK10.49845464
120MAPK80.47580165
121SIK30.47471355
122ROCK10.47363285
123STK40.47353572
124MATK0.47164543
125PDPK10.45932763
126CLK10.45551695
127MARK30.43764935
128MAPK100.43129980
129TIE10.41134292
130IGF1R0.40997089
131RPS6KA60.40896050
132IRAK10.40802348
133DAPK20.38878935
134PRKCD0.38391440
135MAP3K110.37707145
136TAOK20.37136014
137ICK0.36847757
138CAMK40.36390650
139FGR0.34342572
140DYRK1B0.34245728
141RPS6KA40.33752257
142STK30.32120927
143NME20.30442741
144PRKACG0.29684321
145MTOR0.29646994
146ERBB20.29055317

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.31431053
2Complement and coagulation cascades_Homo sapiens_hsa046103.15803028
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.06942520
4Staphylococcus aureus infection_Homo sapiens_hsa051503.02970541
5Nitrogen metabolism_Homo sapiens_hsa009103.02186802
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81828858
7Arginine biosynthesis_Homo sapiens_hsa002202.64538463
8Fatty acid degradation_Homo sapiens_hsa000712.44302628
9Tryptophan metabolism_Homo sapiens_hsa003802.38555739
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34715822
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33523336
12Caffeine metabolism_Homo sapiens_hsa002322.28490107
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04660500
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04030536
15Peroxisome_Homo sapiens_hsa041462.03157400
16Notch signaling pathway_Homo sapiens_hsa043302.01794689
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01680331
18PPAR signaling pathway_Homo sapiens_hsa033201.97913164
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83880402
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.79275958
21Histidine metabolism_Homo sapiens_hsa003401.76556499
22Chemical carcinogenesis_Homo sapiens_hsa052041.71010207
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.69748344
24Fatty acid metabolism_Homo sapiens_hsa012121.68010898
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67038418
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.63716656
27Propanoate metabolism_Homo sapiens_hsa006401.63455172
28ABC transporters_Homo sapiens_hsa020101.60100047
29beta-Alanine metabolism_Homo sapiens_hsa004101.58246020
30Selenocompound metabolism_Homo sapiens_hsa004501.49948117
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49482555
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.47749347
33Retinol metabolism_Homo sapiens_hsa008301.46468013
34GnRH signaling pathway_Homo sapiens_hsa049121.43760337
35VEGF signaling pathway_Homo sapiens_hsa043701.42502323
36Butanoate metabolism_Homo sapiens_hsa006501.41982166
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38908220
38Starch and sucrose metabolism_Homo sapiens_hsa005001.35150932
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.29603431
40Bile secretion_Homo sapiens_hsa049761.22663550
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22633885
42Insulin signaling pathway_Homo sapiens_hsa049101.20102989
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.15004721
44Phenylalanine metabolism_Homo sapiens_hsa003601.14872187
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09292633
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09081406
47mTOR signaling pathway_Homo sapiens_hsa041501.09060603
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08095933
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07595267
50Lysine degradation_Homo sapiens_hsa003101.06960660
51Long-term potentiation_Homo sapiens_hsa047201.05744765
52AMPK signaling pathway_Homo sapiens_hsa041521.05556933
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03346612
54Choline metabolism in cancer_Homo sapiens_hsa052311.00772976
55Insulin secretion_Homo sapiens_hsa049111.00647549
56Oxytocin signaling pathway_Homo sapiens_hsa049211.00058814
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99961580
58Tyrosine metabolism_Homo sapiens_hsa003500.99659626
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99509055
60Renin secretion_Homo sapiens_hsa049240.98443799
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98374618
62Fatty acid elongation_Homo sapiens_hsa000620.96637497
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.96577947
64Folate biosynthesis_Homo sapiens_hsa007900.94924474
65Dilated cardiomyopathy_Homo sapiens_hsa054140.94559614
66Steroid biosynthesis_Homo sapiens_hsa001000.93781431
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93521733
68Fat digestion and absorption_Homo sapiens_hsa049750.93513685
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92768135
70Estrogen signaling pathway_Homo sapiens_hsa049150.91938009
71Pyruvate metabolism_Homo sapiens_hsa006200.91741680
72Glucagon signaling pathway_Homo sapiens_hsa049220.90854244
73Sulfur relay system_Homo sapiens_hsa041220.90258415
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89255732
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87955392
76* Glycerophospholipid metabolism_Homo sapiens_hsa005640.86791569
77Vitamin digestion and absorption_Homo sapiens_hsa049770.86416492
78Gastric acid secretion_Homo sapiens_hsa049710.86299557
79Other glycan degradation_Homo sapiens_hsa005110.86178447
80Carbon metabolism_Homo sapiens_hsa012000.85503073
81Ovarian steroidogenesis_Homo sapiens_hsa049130.85409448
82Biosynthesis of amino acids_Homo sapiens_hsa012300.85365310
83Platelet activation_Homo sapiens_hsa046110.82068044
84Dorso-ventral axis formation_Homo sapiens_hsa043200.81745846
85Lysosome_Homo sapiens_hsa041420.79098853
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.78890599
87Leishmaniasis_Homo sapiens_hsa051400.78673141
88One carbon pool by folate_Homo sapiens_hsa006700.77056544
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76122389
90Vitamin B6 metabolism_Homo sapiens_hsa007500.75998413
91Osteoclast differentiation_Homo sapiens_hsa043800.75728268
92Pentose phosphate pathway_Homo sapiens_hsa000300.75099827
93Glycerolipid metabolism_Homo sapiens_hsa005610.73944174
94TNF signaling pathway_Homo sapiens_hsa046680.73604040
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73473854
96Focal adhesion_Homo sapiens_hsa045100.73152333
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71948696
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.71940308
99Sulfur metabolism_Homo sapiens_hsa009200.70906378
100Circadian rhythm_Homo sapiens_hsa047100.70894624
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70741402
102Inositol phosphate metabolism_Homo sapiens_hsa005620.70455788
103Linoleic acid metabolism_Homo sapiens_hsa005910.68714340
104Prolactin signaling pathway_Homo sapiens_hsa049170.66929976
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66412972
106MAPK signaling pathway_Homo sapiens_hsa040100.66255004
107T cell receptor signaling pathway_Homo sapiens_hsa046600.65293262
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.65204030
109Type II diabetes mellitus_Homo sapiens_hsa049300.64243347
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63837284
111Circadian entrainment_Homo sapiens_hsa047130.63577744
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63070922
113cAMP signaling pathway_Homo sapiens_hsa040240.61992096
114B cell receptor signaling pathway_Homo sapiens_hsa046620.61789443
115Amoebiasis_Homo sapiens_hsa051460.60925282
116Arginine and proline metabolism_Homo sapiens_hsa003300.60739603
117ErbB signaling pathway_Homo sapiens_hsa040120.60228027
118Fatty acid biosynthesis_Homo sapiens_hsa000610.60016686
119Chronic myeloid leukemia_Homo sapiens_hsa052200.59919146
120Calcium signaling pathway_Homo sapiens_hsa040200.59804495
121Glioma_Homo sapiens_hsa052140.58761234
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57689973
123Salivary secretion_Homo sapiens_hsa049700.57534497
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56735388
125Cholinergic synapse_Homo sapiens_hsa047250.56505731
126Synaptic vesicle cycle_Homo sapiens_hsa047210.54688215
127Amphetamine addiction_Homo sapiens_hsa050310.52907193
128Pancreatic secretion_Homo sapiens_hsa049720.52513185
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52175356
130Pertussis_Homo sapiens_hsa051330.51906891
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51089544
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.50665263
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50358205
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50140980
135Insulin resistance_Homo sapiens_hsa049310.49785535
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.49198655
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.48676700
138Endocytosis_Homo sapiens_hsa041440.47977574
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47334708
140Melanogenesis_Homo sapiens_hsa049160.47070488
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45470681
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.45147803
143Glutathione metabolism_Homo sapiens_hsa004800.45052039
144Legionellosis_Homo sapiens_hsa051340.44973896
145Measles_Homo sapiens_hsa051620.44204445
146Malaria_Homo sapiens_hsa051440.43204363
147Prion diseases_Homo sapiens_hsa050200.43017738
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42886521
149Primary immunodeficiency_Homo sapiens_hsa053400.41529876
150Tuberculosis_Homo sapiens_hsa051520.39796949
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38791977
152NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34452182
153Fructose and mannose metabolism_Homo sapiens_hsa000510.31558234
154Galactose metabolism_Homo sapiens_hsa000520.30491054
155Influenza A_Homo sapiens_hsa051640.29116713
156Hematopoietic cell lineage_Homo sapiens_hsa046400.28933849
157Metabolic pathways_Homo sapiens_hsa011000.27610629
158Antigen processing and presentation_Homo sapiens_hsa046120.23050714
159Jak-STAT signaling pathway_Homo sapiens_hsa046300.22222915
160Hepatitis C_Homo sapiens_hsa051600.21381113
161Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19818801
162Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17967061
163Toxoplasmosis_Homo sapiens_hsa051450.17929945
164Acute myeloid leukemia_Homo sapiens_hsa052210.17051737

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