PNPLA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.80185165
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.80185165
3regulation of ER to Golgi vesicle-mediated transport (GO:0060628)5.52467194
4L-phenylalanine metabolic process (GO:0006558)5.48219861
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.48219861
6alpha-linolenic acid metabolic process (GO:0036109)5.25635899
7aromatic amino acid family catabolic process (GO:0009074)5.19146481
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.92114868
9homocysteine metabolic process (GO:0050667)4.71965522
10lysine catabolic process (GO:0006554)4.69176327
11lysine metabolic process (GO:0006553)4.69176327
12cysteine metabolic process (GO:0006534)4.67127859
13serine family amino acid catabolic process (GO:0009071)4.66919250
14indole-containing compound catabolic process (GO:0042436)4.66539820
15indolalkylamine catabolic process (GO:0046218)4.66539820
16tryptophan catabolic process (GO:0006569)4.66539820
17kynurenine metabolic process (GO:0070189)4.63791603
18fatty acid transmembrane transport (GO:1902001)4.63726014
19urea metabolic process (GO:0019627)4.63514043
20urea cycle (GO:0000050)4.63514043
21bile acid biosynthetic process (GO:0006699)4.60880495
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.51954278
23glyoxylate metabolic process (GO:0046487)4.48600596
24complement activation, alternative pathway (GO:0006957)4.47369429
25carnitine shuttle (GO:0006853)4.43568384
26tryptophan metabolic process (GO:0006568)4.41419155
27amino-acid betaine metabolic process (GO:0006577)4.37078478
28regulation of sequestering of triglyceride (GO:0010889)4.35676642
29nitrogen cycle metabolic process (GO:0071941)4.26957278
30regulation of triglyceride catabolic process (GO:0010896)4.24279376
31sulfur amino acid catabolic process (GO:0000098)4.23021570
32acylglycerol homeostasis (GO:0055090)4.18186872
33triglyceride homeostasis (GO:0070328)4.18186872
34pyrimidine nucleobase catabolic process (GO:0006208)4.15771482
35acetyl-CoA metabolic process (GO:0006084)4.15764039
36dicarboxylic acid biosynthetic process (GO:0043650)4.13132274
37fatty acid beta-oxidation (GO:0006635)4.12749723
38short-chain fatty acid metabolic process (GO:0046459)4.07334060
39alpha-amino acid catabolic process (GO:1901606)4.05617012
40bile acid metabolic process (GO:0008206)4.04150418
41regulation of protein activation cascade (GO:2000257)4.03708604
42positive regulation of fatty acid beta-oxidation (GO:0032000)3.99199485
43high-density lipoprotein particle remodeling (GO:0034375)3.93989232
44fatty acid oxidation (GO:0019395)3.91891367
45peptidyl-glutamic acid carboxylation (GO:0017187)3.90417437
46protein carboxylation (GO:0018214)3.90417437
47cellular ketone body metabolic process (GO:0046950)3.89738077
482-oxoglutarate metabolic process (GO:0006103)3.86742275
49lipid oxidation (GO:0034440)3.85637917
50glutamate metabolic process (GO:0006536)3.81348787
51cellular amino acid catabolic process (GO:0009063)3.80815052
52fatty acid catabolic process (GO:0009062)3.80613037
53valine metabolic process (GO:0006573)3.79824175
54negative regulation of fibrinolysis (GO:0051918)3.79455051
55regulation of fibrinolysis (GO:0051917)3.79379315
56regulation of complement activation (GO:0030449)3.79130822
57biotin metabolic process (GO:0006768)3.78850913
58adaptation of signaling pathway (GO:0023058)3.75651746
59plasma lipoprotein particle clearance (GO:0034381)3.74162449
60phospholipid homeostasis (GO:0055091)3.73506138
61fatty acid homeostasis (GO:0055089)3.73378992
62positive regulation of lipid catabolic process (GO:0050996)3.71188837
63aromatic amino acid family metabolic process (GO:0009072)3.70996887
64tyrosine metabolic process (GO:0006570)3.69331344
65negative regulation of fatty acid biosynthetic process (GO:0045717)3.63953331
66branched-chain amino acid catabolic process (GO:0009083)3.63479964
67monocarboxylic acid catabolic process (GO:0072329)3.63361301
68aspartate family amino acid catabolic process (GO:0009068)3.62968057
69positive regulation of fatty acid oxidation (GO:0046321)3.59682056
70reverse cholesterol transport (GO:0043691)3.59627991
71negative regulation of mast cell activation (GO:0033004)3.58318141
72imidazole-containing compound metabolic process (GO:0052803)3.54701233
73carboxylic acid catabolic process (GO:0046395)3.52592246
74organic acid catabolic process (GO:0016054)3.52592246
75coenzyme catabolic process (GO:0009109)3.51343786
76protein-lipid complex remodeling (GO:0034368)3.51085099
77macromolecular complex remodeling (GO:0034367)3.51085099
78plasma lipoprotein particle remodeling (GO:0034369)3.51085099
79glycine metabolic process (GO:0006544)3.51014462
80negative regulation of lipase activity (GO:0060192)3.50245631
81carnitine transmembrane transport (GO:1902603)3.49018379
82carnitine metabolic process (GO:0009437)3.47791226
83ethanol oxidation (GO:0006069)3.45724923
84neuronal action potential propagation (GO:0019227)3.45497581
85neutral lipid catabolic process (GO:0046461)3.44648289
86acylglycerol catabolic process (GO:0046464)3.44648289
87carnitine transport (GO:0015879)3.41861819
88amino-acid betaine transport (GO:0015838)3.41861819
89serine family amino acid metabolic process (GO:0009069)3.41608373
90triglyceride catabolic process (GO:0019433)3.37632000
91branched-chain amino acid metabolic process (GO:0009081)3.36644043
92cellular modified amino acid catabolic process (GO:0042219)3.36286889
93regulation of bile acid biosynthetic process (GO:0070857)3.36042557
94drug catabolic process (GO:0042737)3.35367487
95low-density lipoprotein particle clearance (GO:0034383)3.34649725
96neuron cell-cell adhesion (GO:0007158)3.33662153
97ketone body metabolic process (GO:1902224)3.32853619
98indolalkylamine metabolic process (GO:0006586)3.28804401
99nucleobase catabolic process (GO:0046113)3.28426242
100regulation of fatty acid beta-oxidation (GO:0031998)3.24936907
101negative regulation of cholesterol transport (GO:0032375)3.23976602
102negative regulation of sterol transport (GO:0032372)3.23976602
103phospholipid efflux (GO:0033700)3.23575039
104cellular glucuronidation (GO:0052695)3.16038278
105* linoleic acid metabolic process (GO:0043651)3.13970467
106bile acid and bile salt transport (GO:0015721)3.12998159
107protein targeting to Golgi (GO:0000042)3.10681712
108response to pheromone (GO:0019236)3.08938771
109regulation of synapse structural plasticity (GO:0051823)3.08521613
110amine catabolic process (GO:0009310)3.08332038
111negative regulation of neurotransmitter transport (GO:0051589)3.03804588
112interleukin-6-mediated signaling pathway (GO:0070102)3.03538103
113establishment of protein localization to Golgi (GO:0072600)3.00596884
114regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96366509
115auditory behavior (GO:0031223)2.95906324
116vesicle transport along microtubule (GO:0047496)2.95257479
117positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.95016319
118mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.95016319
119protein K11-linked deubiquitination (GO:0035871)2.91393279
120presynaptic membrane assembly (GO:0097105)2.86837002
121neural tube formation (GO:0001841)2.85033920
122synaptic vesicle maturation (GO:0016188)2.83533995
123nerve growth factor signaling pathway (GO:0038180)2.81774071
124neutrophil mediated immunity (GO:0002446)2.80851873
125negative regulation of neurotransmitter secretion (GO:0046929)2.79458156
126detection of calcium ion (GO:0005513)2.77435364
127regulation of fever generation (GO:0031620)2.76590607
128retrograde transport, vesicle recycling within Golgi (GO:0000301)2.75622311
129G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73848966
130regulation of heat generation (GO:0031650)2.72227119
131organelle transport along microtubule (GO:0072384)2.70644059
132positive regulation of heat generation (GO:0031652)2.69943101
133regulation of axon regeneration (GO:0048679)2.68022395
134regulation of neuron projection regeneration (GO:0070570)2.68022395
135negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.67438223
136exploration behavior (GO:0035640)2.66382845
137regulation of glucokinase activity (GO:0033131)2.66101603
138regulation of hexokinase activity (GO:1903299)2.66101603
139protein localization to cilium (GO:0061512)2.61848745
140axonal fasciculation (GO:0007413)2.60861403
141proline transport (GO:0015824)2.59521942
142platelet dense granule organization (GO:0060155)2.59404099
143regulation of feeding behavior (GO:0060259)2.57863635
144gamma-aminobutyric acid transport (GO:0015812)2.57778003
145regulation of synaptic vesicle transport (GO:1902803)2.57748826
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57425035
147regulation of synaptic transmission, glutamatergic (GO:0051966)2.56743047
148vocalization behavior (GO:0071625)2.55583506
149mechanosensory behavior (GO:0007638)2.54736962
150regulation of synaptic vesicle exocytosis (GO:2000300)2.51793851
151presynaptic membrane organization (GO:0097090)2.51512396
152neurotransmitter-gated ion channel clustering (GO:0072578)2.51158316
153protein localization to synapse (GO:0035418)2.50904465
154negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50600899
155establishment of mitochondrion localization (GO:0051654)2.49573256
156positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.47319794
157negative regulation of JUN kinase activity (GO:0043508)2.44146119
158cAMP-mediated signaling (GO:0019933)2.43158353
159positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.40030453
160negative regulation of dendrite development (GO:2000171)2.39478519
161positive regulation of vasculogenesis (GO:2001214)2.39112960
162protein localization to Golgi apparatus (GO:0034067)2.38918865
163postsynaptic membrane organization (GO:0001941)2.37521807
164glutamate receptor signaling pathway (GO:0007215)2.37437006
165protein targeting to vacuole (GO:0006623)2.36847325
166protein targeting to lysosome (GO:0006622)2.36847325
167establishment of protein localization to vacuole (GO:0072666)2.36847325
168regulation of transmission of nerve impulse (GO:0051969)2.36433762
169synapse assembly (GO:0007416)2.35266670
170negative regulation of NF-kappaB import into nucleus (GO:0042347)2.32732470
171response to auditory stimulus (GO:0010996)2.30297023
172epithelial cell differentiation involved in kidney development (GO:0035850)2.30114991
173alanine transport (GO:0032328)2.28890510
174glycosphingolipid biosynthetic process (GO:0006688)2.28777204
175epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.28771327
176activated T cell proliferation (GO:0050798)2.28567314
177positive regulation of mitochondrial fission (GO:0090141)2.27499749
178myeloid leukocyte mediated immunity (GO:0002444)2.27140531
179ionotropic glutamate receptor signaling pathway (GO:0035235)2.26133329
180dendritic spine morphogenesis (GO:0060997)2.25749021
181positive regulation of amino acid transport (GO:0051957)2.25617230
182neuron-neuron synaptic transmission (GO:0007270)2.25271208
183locomotory exploration behavior (GO:0035641)2.24690632
184regulation of action potential (GO:0098900)2.23670965
185piRNA metabolic process (GO:0034587)2.23581331
186regulation of cAMP-dependent protein kinase activity (GO:2000479)2.22917392
187membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21572993
188dendrite morphogenesis (GO:0048813)2.21485812
189C4-dicarboxylate transport (GO:0015740)2.20846127
190dopamine biosynthetic process (GO:0042416)2.20375753
191regulation of neurotransmitter secretion (GO:0046928)2.19837198
192regulation of cilium movement (GO:0003352)2.19161185
193macroautophagy (GO:0016236)2.18645616
194neuron recognition (GO:0008038)2.18321521
195transmission of nerve impulse (GO:0019226)2.16697599
196glutamate secretion (GO:0014047)2.16312471
197cerebral cortex radially oriented cell migration (GO:0021799)2.15978402
198regulation of protein glycosylation (GO:0060049)2.15961806
199positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.14231358
200intraciliary transport (GO:0042073)2.13310564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.26041890
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.21326648
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.77846517
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.58726349
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.38102441
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.33544910
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.13180204
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.37590201
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.11052938
10EZH2_22144423_ChIP-Seq_EOC_Human3.02217382
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89739500
12IGF1R_20145208_ChIP-Seq_DFB_Human2.44918723
13* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.42266296
14VDR_22108803_ChIP-Seq_LS180_Human2.34274023
15* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20326686
16SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.15683634
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10757420
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.02992685
19ZNF274_21170338_ChIP-Seq_K562_Hela1.97349212
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.94900172
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87192063
22GBX2_23144817_ChIP-Seq_PC3_Human1.82260107
23* ER_23166858_ChIP-Seq_MCF-7_Human1.74597736
24* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59287802
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58987386
26TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58947604
27FUS_26573619_Chip-Seq_HEK293_Human1.56862578
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56810405
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.48580005
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.46525570
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46471479
32EWS_26573619_Chip-Seq_HEK293_Human1.46296756
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45619230
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.44826640
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44624302
36FLI1_21867929_ChIP-Seq_TH2_Mouse1.42734284
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39215400
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38458014
39GATA1_22025678_ChIP-Seq_K562_Human1.36402156
40CBP_20019798_ChIP-Seq_JUKART_Human1.35566829
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35566829
42BCAT_22108803_ChIP-Seq_LS180_Human1.33880596
43HTT_18923047_ChIP-ChIP_STHdh_Human1.33804154
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31766151
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.30501955
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29875144
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28043866
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27695712
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25252265
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24651667
51P53_22387025_ChIP-Seq_ESCs_Mouse1.24223190
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23311783
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21964698
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21378111
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21085334
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21085334
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.20560320
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.17346123
59TP53_18474530_ChIP-ChIP_U2OS_Human1.16435421
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.16318628
61TAF15_26573619_Chip-Seq_HEK293_Human1.15587769
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15586200
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.15423058
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.15314480
65TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15291133
66JUN_21703547_ChIP-Seq_K562_Human1.14925006
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14761946
68RUNX2_22187159_ChIP-Seq_PCA_Human1.12439028
69RNF2_27304074_Chip-Seq_NSC_Mouse1.11628865
70CLOCK_20551151_ChIP-Seq_293T_Human1.11354152
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10963035
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10525209
73CJUN_26792858_Chip-Seq_BT549_Human1.10266374
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10088463
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09924672
76* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08973088
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08235936
78SMAD4_21799915_ChIP-Seq_A2780_Human1.07376492
79NANOG_19829295_ChIP-Seq_ESCs_Human1.07360478
80SOX2_19829295_ChIP-Seq_ESCs_Human1.07360478
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06776467
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06300511
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05707104
84KDM2B_26808549_Chip-Seq_REH_Human1.03903130
85HNF4A_19822575_ChIP-Seq_HepG2_Human1.03230775
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03068876
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02867406
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02759005
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00820298
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00059506
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99689972
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.99498513
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98970278
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97703319
95STAT3_23295773_ChIP-Seq_U87_Human0.97621682
96DROSHA_22980978_ChIP-Seq_HELA_Human0.97259959
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.96384569
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95747859
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94150638
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93411244
101* SOX2_21211035_ChIP-Seq_LN229_Gbm0.93382373
102CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92846096
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92712307
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92592358
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91210649
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90293898
107* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89673276
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88897508
109CDX2_22108803_ChIP-Seq_LS180_Human0.88510882
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88376912
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88376912
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87077484
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86733330
114OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86223299
115* P300_19829295_ChIP-Seq_ESCs_Human0.86062517
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85604265
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85206622
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84288471
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.83877882
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83256443
121AR_21572438_ChIP-Seq_LNCaP_Human0.81835035
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81343495
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81184427
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81015904
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80765668
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80393003
127* AR_25329375_ChIP-Seq_VCAP_Human0.80262047
128* TCF4_22108803_ChIP-Seq_LS180_Human0.79842965
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79819882
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79106274
131AHR_22903824_ChIP-Seq_MCF-7_Human0.78991362
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78984009
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.78896402
134CBP_21632823_ChIP-Seq_H3396_Human0.78805649
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.78681440
136ZNF263_19887448_ChIP-Seq_K562_Human0.78670310
137TCF4_23295773_ChIP-Seq_U87_Human0.78087307
138TP53_16413492_ChIP-PET_HCT116_Human0.77824192
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77659007
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76765879
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.76139194
142HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76055854
143REST_21632747_ChIP-Seq_MESCs_Mouse0.74768712
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.73616849
145TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73560085
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73526002
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.73076135
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.73011344
149AR_19668381_ChIP-Seq_PC3_Human0.72372651
150STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.72184326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.86196645
2MP0005360_urolithiasis6.11183795
3MP0005085_abnormal_gallbladder_physiolo5.32198072
4MP0005365_abnormal_bile_salt5.20678845
5MP0000569_abnormal_digit_pigmentation4.34939924
6MP0008875_abnormal_xenobiotic_pharmacok3.76820260
7MP0010329_abnormal_lipoprotein_level3.47145880
8MP0003880_abnormal_central_pattern3.39576288
9MP0003806_abnormal_nucleotide_metabolis3.37797000
10MP0003252_abnormal_bile_duct3.36387703
11MP0003787_abnormal_imprinting3.29210186
12MP0005670_abnormal_white_adipose3.05664219
13MP0004130_abnormal_muscle_cell2.84248510
14MP0003195_calcinosis2.72994340
15MP0005332_abnormal_amino_acid2.57666276
16MP0002837_dystrophic_cardiac_calcinosis2.45370969
17MP0005083_abnormal_biliary_tract2.36680876
18MP0008877_abnormal_DNA_methylation2.31584449
19MP0005666_abnormal_adipose_tissue2.28640987
20MP0002138_abnormal_hepatobiliary_system2.28271739
21MP0009745_abnormal_behavioral_response2.23935890
22MP0002118_abnormal_lipid_homeostasis2.23576797
23MP0002102_abnormal_ear_morphology2.21503095
24MP0004019_abnormal_vitamin_homeostasis2.14984425
25MP0003724_increased_susceptibility_to2.11329250
26MP0005423_abnormal_somatic_nervous2.11064728
27MP0002272_abnormal_nervous_system2.10383200
28MP0009840_abnormal_foam_cell1.92915845
29MP0002064_seizures1.92239374
30MP0000609_abnormal_liver_physiology1.91246194
31MP0003191_abnormal_cellular_cholesterol1.87682116
32MP0001666_abnormal_nutrient_absorption1.87650996
33MP0004185_abnormal_adipocyte_glucose1.86132634
34MP0003635_abnormal_synaptic_transmissio1.85881231
35MP0003303_peritoneal_inflammation1.84889074
36MP0002735_abnormal_chemical_nociception1.82207037
37MP0002063_abnormal_learning/memory/cond1.81135557
38MP0001529_abnormal_vocalization1.68893711
39MP0003646_muscle_fatigue1.67365761
40MP0001968_abnormal_touch/_nociception1.62332923
41MP0002736_abnormal_nociception_after1.61447255
42MP0005451_abnormal_body_composition1.61088458
43MP0001984_abnormal_olfaction1.60771305
44MP0001661_extended_life_span1.60062725
45MP0005253_abnormal_eye_physiology1.59974882
46MP0002653_abnormal_ependyma_morphology1.59133124
47MP0003868_abnormal_feces_composition1.58832860
48MP0005551_abnormal_eye_electrophysiolog1.58197458
49MP0002971_abnormal_brown_adipose1.57716429
50MP0002572_abnormal_emotion/affect_behav1.57711828
51MP0006072_abnormal_retinal_apoptosis1.57620702
52MP0002254_reproductive_system_inflammat1.53421305
53MP0004142_abnormal_muscle_tone1.53117571
54MP0002638_abnormal_pupillary_reflex1.52706480
55MP0002822_catalepsy1.52158729
56MP0002734_abnormal_mechanical_nocicepti1.51699496
57MP0000778_abnormal_nervous_system1.50447885
58MP0003705_abnormal_hypodermis_morpholog1.48817944
59MP0003656_abnormal_erythrocyte_physiolo1.47878482
60MP0001502_abnormal_circadian_rhythm1.46910206
61MP0005319_abnormal_enzyme/_coenzyme1.45617112
62MP0005386_behavior/neurological_phenoty1.43533971
63MP0004924_abnormal_behavior1.43533971
64MP0001905_abnormal_dopamine_level1.41673036
65MP0002067_abnormal_sensory_capabilities1.37750136
66MP0004147_increased_porphyrin_level1.37738516
67MP0005375_adipose_tissue_phenotype1.37181594
68* MP0005535_abnormal_body_temperature1.35577322
69MP0006276_abnormal_autonomic_nervous1.34917976
70MP0010234_abnormal_vibrissa_follicle1.34638502
71MP0003121_genomic_imprinting1.34599426
72MP0005584_abnormal_enzyme/coenzyme_acti1.33669127
73MP0001970_abnormal_pain_threshold1.33643026
74MP0004885_abnormal_endolymph1.32841313
75MP0003890_abnormal_embryonic-extraembry1.32084063
76MP0002078_abnormal_glucose_homeostasis1.31732462
77MP0005647_abnormal_sex_gland1.30316024
78MP0003221_abnormal_cardiomyocyte_apopto1.29760413
79MP0001764_abnormal_homeostasis1.26479061
80MP0005334_abnormal_fat_pad1.25915754
81MP0002876_abnormal_thyroid_physiology1.23764397
82MP0004484_altered_response_of1.21563128
83MP0006082_CNS_inflammation1.14665125
84MP0009780_abnormal_chondrocyte_physiolo1.14570818
85MP0003828_pulmonary_edema1.11966511
86MP0004043_abnormal_pH_regulation1.11197947
87MP0003631_nervous_system_phenotype1.09785923
88MP0002557_abnormal_social/conspecific_i1.06705144
89MP0003045_fibrosis1.05927929
90MP0009643_abnormal_urine_homeostasis1.05814197
91MP0003122_maternal_imprinting1.05634018
92MP0000920_abnormal_myelination1.04676184
93MP0004811_abnormal_neuron_physiology1.04393730
94MP0005646_abnormal_pituitary_gland1.02216973
95MP0004742_abnormal_vestibular_system0.99260962
96MP0010386_abnormal_urinary_bladder0.98605942
97MP0003690_abnormal_glial_cell0.97298596
98MP0002229_neurodegeneration0.96103659
99MP0009697_abnormal_copulation0.95837425
100MP0005448_abnormal_energy_balance0.93123861
101MP0002733_abnormal_thermal_nociception0.92331064
102MP0000647_abnormal_sebaceous_gland0.91262110
103* MP0006036_abnormal_mitochondrial_physio0.90155817
104MP0002882_abnormal_neuron_morphology0.88928636
105MP0006054_spinal_hemorrhage0.88221318
106MP0001188_hyperpigmentation0.87838417
107* MP0005266_abnormal_metabolism0.87150647
108MP0001986_abnormal_taste_sensitivity0.85632902
109MP0000427_abnormal_hair_cycle0.84078099
110MP0003950_abnormal_plasma_membrane0.83894929
111MP0000604_amyloidosis0.82256541
112MP0004215_abnormal_myocardial_fiber0.82138909
113MP0002148_abnormal_hypersensitivity_rea0.81242166
114MP0002269_muscular_atrophy0.79528597
115MP0005167_abnormal_blood-brain_barrier0.78782137
116MP0002277_abnormal_respiratory_mucosa0.78781069
117MP0000955_abnormal_spinal_cord0.77863048
118MP0009785_altered_susceptibility_to0.77458900
119MP0000013_abnormal_adipose_tissue0.77278660
120MP0008995_early_reproductive_senescence0.77166601
121* MP0009763_increased_sensitivity_to0.75629045
122MP0002184_abnormal_innervation0.75494299
123MP0003186_abnormal_redox_activity0.74206705
124MP0003953_abnormal_hormone_level0.73472791
125MP0002066_abnormal_motor_capabilities/c0.71742221
126MP0000343_altered_response_to0.71725776
127MP0000598_abnormal_liver_morphology0.71371817
128MP0002928_abnormal_bile_duct0.71341816
129MP0009115_abnormal_fat_cell0.70814059
130* MP0005376_homeostasis/metabolism_phenot0.70166739
131MP0005620_abnormal_muscle_contractility0.69543320
132MP0000003_abnormal_adipose_tissue0.69309653
133MP0001756_abnormal_urination0.68972296
134MP0009764_decreased_sensitivity_to0.64639953
135MP0004036_abnormal_muscle_relaxation0.64589006
136MP0003634_abnormal_glial_cell0.64523239
137MP0005164_abnormal_response_to0.63867138
138MP0009642_abnormal_blood_homeostasis0.63535446
139MP0008775_abnormal_heart_ventricle0.61880751
140MP0002909_abnormal_adrenal_gland0.61773538
141MP0000230_abnormal_systemic_arterial0.61490075
142MP0009672_abnormal_birth_weight0.59210676
143MP0001881_abnormal_mammary_gland0.58291688
144MP0002970_abnormal_white_adipose0.57995855
145MP0006035_abnormal_mitochondrial_morpho0.55698513
146MP0005452_abnormal_adipose_tissue0.55111097
147MP0004270_analgesia0.54889122
148MP0002168_other_aberrant_phenotype0.54717993
149MP0003329_amyloid_beta_deposits0.54634600
150MP0000579_abnormal_nail_morphology0.54581548
151MP0000751_myopathy0.53517321
152MP0009765_abnormal_xenobiotic_induced0.53286293
153MP0003011_delayed_dark_adaptation0.52734808
154MP0001501_abnormal_sleep_pattern0.52647517
155MP0005395_other_phenotype0.52389893
156MP0005636_abnormal_mineral_homeostasis0.52039022
157MP0004859_abnormal_synaptic_plasticity0.51753358
158* MP0002332_abnormal_exercise_endurance0.51395677
159MP0008961_abnormal_basal_metabolism0.51122380
160MP0001486_abnormal_startle_reflex0.50700624
161MP0005248_abnormal_Harderian_gland0.50612551
162MP0008872_abnormal_physiological_respon0.50212553
163MP0009046_muscle_twitch0.50083863
164MP0006138_congestive_heart_failure0.50049355
165MP0002090_abnormal_vision0.48952314
166MP0003633_abnormal_nervous_system0.47895441
167MP0005187_abnormal_penis_morphology0.47861570
168MP0003959_abnormal_lean_body0.46311967
169MP0005330_cardiomyopathy0.46174417
170MP0008874_decreased_physiological_sensi0.45713777
171MP0001440_abnormal_grooming_behavior0.44786102
172MP0004087_abnormal_muscle_fiber0.44459458

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.91620140
2Hyperglycinuria (HP:0003108)5.42610402
3Hyperglycinemia (HP:0002154)5.15733561
4Deep venous thrombosis (HP:0002625)5.10179352
5Xanthomatosis (HP:0000991)5.08163620
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.06077920
7Abnormality of serine family amino acid metabolism (HP:0010894)4.94192509
8Abnormality of glycine metabolism (HP:0010895)4.94192509
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.75733499
10Hyperlipoproteinemia (HP:0010980)4.73407405
11Hypoalphalipoproteinemia (HP:0003233)4.69613400
12Ketosis (HP:0001946)4.65339534
13Hypoglycemic coma (HP:0001325)4.47224189
14Epidermoid cyst (HP:0200040)4.45175255
15Hyperammonemia (HP:0001987)4.42881225
16Prolonged partial thromboplastin time (HP:0003645)4.39083040
17Complement deficiency (HP:0004431)4.31845982
18Hypolipoproteinemia (HP:0010981)4.18955096
19Ketoacidosis (HP:0001993)4.14264499
20Atonic seizures (HP:0010819)4.12386148
21Hypobetalipoproteinemia (HP:0003563)4.09643795
22Focal motor seizures (HP:0011153)4.09418597
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.95676279
24Febrile seizures (HP:0002373)3.93571423
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78590751
26Focal seizures (HP:0007359)3.58418291
27Abnormality of fatty-acid metabolism (HP:0004359)3.48799389
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.34058027
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.33375453
30Abnormality of serum amino acid levels (HP:0003112)3.29358097
31Polyphagia (HP:0002591)3.27908888
32Limb dystonia (HP:0002451)3.18031073
33Pancreatic cysts (HP:0001737)3.17258021
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.12970605
35Dialeptic seizures (HP:0011146)3.11721165
36Amyotrophic lateral sclerosis (HP:0007354)3.11403663
37True hermaphroditism (HP:0010459)3.10651280
38Abnormality of methionine metabolism (HP:0010901)3.10124282
39Hyperglycemia (HP:0003074)3.01169967
40Pancreatic fibrosis (HP:0100732)2.99838581
41Joint hemorrhage (HP:0005261)2.97308911
42Abnormality of pyrimidine metabolism (HP:0004353)2.93960865
43Absent speech (HP:0001344)2.89985426
44Drooling (HP:0002307)2.88842506
45Hypercholesterolemia (HP:0003124)2.88819895
46Abnormality of the common coagulation pathway (HP:0010990)2.87908007
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87502564
48Dicarboxylic aciduria (HP:0003215)2.87502564
49Fat malabsorption (HP:0002630)2.86440825
50Abnormality of nucleobase metabolism (HP:0010932)2.86284316
51Abnormality of purine metabolism (HP:0004352)2.82446041
52Hypoglycemic seizures (HP:0002173)2.82153244
53Skin nodule (HP:0200036)2.81314016
54Hemiparesis (HP:0001269)2.78314863
55Action tremor (HP:0002345)2.76979812
56Hyperinsulinemic hypoglycemia (HP:0000825)2.76785958
57Hydroxyprolinuria (HP:0003080)2.76770795
58Abnormality of proline metabolism (HP:0010907)2.76770795
59Chronic hepatic failure (HP:0100626)2.72486054
60Abnormality of complement system (HP:0005339)2.72371916
61Conjugated hyperbilirubinemia (HP:0002908)2.69849345
62Gout (HP:0001997)2.69737458
63Excessive salivation (HP:0003781)2.69197341
64Gait imbalance (HP:0002141)2.68474443
65Medial flaring of the eyebrow (HP:0010747)2.67144947
66Absence seizures (HP:0002121)2.66473083
67Delayed CNS myelination (HP:0002188)2.62031262
68Mutism (HP:0002300)2.61815956
69Abnormality of the intrinsic pathway (HP:0010989)2.60472203
70Papillary thyroid carcinoma (HP:0002895)2.58764543
71Metabolic acidosis (HP:0001942)2.57441826
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.56717004
73Pheochromocytoma (HP:0002666)2.54537932
74Renal cortical cysts (HP:0000803)2.53548518
75Myoglobinuria (HP:0002913)2.51048926
76Myocardial infarction (HP:0001658)2.50341089
77Metaphyseal dysplasia (HP:0100255)2.45610485
78Spastic diplegia (HP:0001264)2.44880654
79Insulin-resistant diabetes mellitus (HP:0000831)2.43662962
80Oligomenorrhea (HP:0000876)2.43530772
81Hypothermia (HP:0002045)2.42990731
82Hyperuricemia (HP:0002149)2.42894386
83Increased purine levels (HP:0004368)2.42894386
84Abnormality of midbrain morphology (HP:0002418)2.42379907
85Molar tooth sign on MRI (HP:0002419)2.42379907
86Broad-based gait (HP:0002136)2.41433426
87Short tibia (HP:0005736)2.41247138
88Ulnar claw (HP:0001178)2.39534367
89Congenital primary aphakia (HP:0007707)2.35300685
90Generalized tonic-clonic seizures (HP:0002069)2.33596578
91Lethargy (HP:0001254)2.33307313
92Generalized aminoaciduria (HP:0002909)2.29736281
93Esotropia (HP:0000565)2.28015835
94Hypochromic microcytic anemia (HP:0004840)2.27509984
95Tubulointerstitial fibrosis (HP:0005576)2.27175078
96Abnormality of liposaccharide metabolism (HP:0010968)2.26040628
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.26040628
98Abnormality of glycolipid metabolism (HP:0010969)2.26040628
99Nephrogenic diabetes insipidus (HP:0009806)2.24741729
100Pendular nystagmus (HP:0012043)2.24390149
101Hepatocellular carcinoma (HP:0001402)2.24328373
102Peripheral hypomyelination (HP:0007182)2.23979063
103Status epilepticus (HP:0002133)2.22830605
104Neoplasm of the tracheobronchial system (HP:0100552)2.20099393
105Abolished electroretinogram (ERG) (HP:0000550)2.19957999
106Cortical dysplasia (HP:0002539)2.19103810
107EEG with generalized epileptiform discharges (HP:0011198)2.19026161
108Cerebral edema (HP:0002181)2.18225480
109Epileptiform EEG discharges (HP:0011182)2.17297142
110Stomatitis (HP:0010280)2.17255408
111Nephronophthisis (HP:0000090)2.17251521
112Hypsarrhythmia (HP:0002521)2.16398405
113Sensorimotor neuropathy (HP:0007141)2.13331846
114Spontaneous abortion (HP:0005268)2.12933929
115Alveolar cell carcinoma (HP:0006519)2.12285346
116Abnormality of the renal cortex (HP:0011035)2.11585637
117Neuroendocrine neoplasm (HP:0100634)2.09702376
118Pachygyria (HP:0001302)2.09413124
119Proximal tubulopathy (HP:0000114)2.07225983
120Hypertriglyceridemia (HP:0002155)2.07005105
121Atrophy/Degeneration involving motor neurons (HP:0007373)2.06475869
122Thyroid carcinoma (HP:0002890)2.06370283
123Progressive cerebellar ataxia (HP:0002073)2.06351583
124Pancreatitis (HP:0001733)2.06016598
125Cholelithiasis (HP:0001081)2.05934006
126Esophageal varix (HP:0002040)2.05439497
127Exercise-induced myalgia (HP:0003738)2.05351962
128Hyperbilirubinemia (HP:0002904)2.05119156
129Rhabdomyolysis (HP:0003201)2.04112652
130Abnormal gallbladder morphology (HP:0012437)2.03754914
131Gaze-evoked nystagmus (HP:0000640)2.02723810
132Widely spaced teeth (HP:0000687)2.01623400
133Global brain atrophy (HP:0002283)2.01029732
134Postural instability (HP:0002172)1.99848801
135Albinism (HP:0001022)1.99102093
136Irritability (HP:0000737)1.98679504
137Agitation (HP:0000713)1.98029266
138Steatorrhea (HP:0002570)1.97428255
139Confusion (HP:0001289)1.97319978
140Abnormal biliary tract physiology (HP:0012439)1.96867642
141Bile duct proliferation (HP:0001408)1.96867642
142Spastic tetraplegia (HP:0002510)1.96480845
143Specific learning disability (HP:0001328)1.95302569
144Optic neuritis (HP:0100653)1.93415934
145Retrobulbar optic neuritis (HP:0100654)1.93415934
146Abnormal eating behavior (HP:0100738)1.92387358
147Abnormality of macular pigmentation (HP:0008002)1.92317615
148Neonatal onset (HP:0003623)1.91598058
149Genital tract atresia (HP:0001827)1.91426334
150Hemiplegia (HP:0002301)1.90662054
151Epileptic encephalopathy (HP:0200134)1.90449411
152Dysdiadochokinesis (HP:0002075)1.88284569
153Vascular calcification (HP:0004934)1.87896731
154Polydipsia (HP:0001959)1.87425051
155Abnormal drinking behavior (HP:0030082)1.87425051
156Turricephaly (HP:0000262)1.86772870
157Hyporeflexia of lower limbs (HP:0002600)1.86671290
158Symptomatic seizures (HP:0011145)1.85892185
159Acanthosis nigricans (HP:0000956)1.85087448
160Fair hair (HP:0002286)1.84705381
161Vomiting (HP:0002013)1.83996820
162Inappropriate behavior (HP:0000719)1.83215110
163Nausea (HP:0002018)1.82995700
164Parakeratosis (HP:0001036)1.82380663
165Enlarged kidneys (HP:0000105)1.81392464
166Neurofibrillary tangles (HP:0002185)1.81250972
167Generalized myoclonic seizures (HP:0002123)1.81105108
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.80722793
169Hematochezia (HP:0002573)1.80177043
170Disinhibition (HP:0000734)1.80132079
171Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79769386
172Degeneration of the lateral corticospinal tracts (HP:0002314)1.79769386
173Tetraparesis (HP:0002273)1.79386212
174Hemorrhage of the eye (HP:0011885)1.79038910
175Abnormality of the renal medulla (HP:0100957)1.77722334
176Dyskinesia (HP:0100660)1.76992255
177Tubular atrophy (HP:0000092)1.76818966
178Abnormality of the lower motor neuron (HP:0002366)1.75246468
179Tubulointerstitial abnormality (HP:0001969)1.74787828
180Generalized hypopigmentation (HP:0007513)1.74202768
181Delayed gross motor development (HP:0002194)1.73681084
182Myokymia (HP:0002411)1.73526949
183Progressive inability to walk (HP:0002505)1.73039734
184Abnormality of salivation (HP:0100755)1.72879467
185Atrioventricular block (HP:0001678)1.72647674
186Absent/shortened dynein arms (HP:0200106)1.71689380
187Dynein arm defect of respiratory motile cilia (HP:0012255)1.71689380
188Stroke (HP:0001297)1.71103817
189Urinary bladder sphincter dysfunction (HP:0002839)1.70830276
190Insulin resistance (HP:0000855)1.70700698
191Upper motor neuron abnormality (HP:0002127)1.67794850
192Hyperventilation (HP:0002883)1.65501490
193Brushfield spots (HP:0001088)1.65104960
194Difficulty running (HP:0009046)1.64802962
195Cardiovascular calcification (HP:0011915)1.64738775
196Limb hypertonia (HP:0002509)1.63604912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.30289724
2CASK3.61361122
3INSRR3.35657580
4PDK33.20722980
5PDK43.20722980
6CAMK1D2.58448329
7MAP4K22.41747377
8MAP3K122.36201096
9MAP3K92.35986614
10EPHA32.30219045
11LATS12.25987248
12PDK22.15819867
13SIK12.13909952
14FRK2.12926554
15ERBB42.10622332
16MAP3K132.09935686
17MAP2K41.91124718
18FLT31.81509214
19CAMK1G1.80073318
20EIF2AK31.79808951
21PLK21.79507799
22STK38L1.76481050
23RIPK11.76030054
24DAPK21.72913793
25BMPR1B1.71001221
26MAP3K41.67979437
27ERBB31.66251132
28WNK31.61283487
29EPHA21.58526137
30MAPK131.57284444
31NTRK31.54122157
32PRKAA21.53927403
33IRAK11.49264351
34EPHA41.46153766
35BMPR21.45493875
36FGFR41.45337218
37NEK11.45048319
38FGFR21.44380398
39PKN21.40054546
40PHKG21.34866343
41PHKG11.34866343
42AKT31.33280935
43KSR21.31961161
44CAMKK21.28182920
45MAP2K71.27742565
46MARK11.24850623
47TRIM281.23645674
48CSNK1G21.21667939
49PRKAA11.20983151
50LATS21.19730640
51MAP3K71.18909276
52SGK21.18057761
53BRD41.12821076
54MAP3K21.12723439
55PINK11.12111398
56OXSR11.11938609
57STK381.10984059
58MINK11.07287927
59PRKCE1.05769333
60OBSCN1.05392998
61PRKD31.04339923
62SGK31.03042351
63PIK3CG1.00516868
64STK390.99672919
65KSR10.96784454
66PAK60.95968529
67TTN0.95233987
68ZAK0.92321743
69DYRK30.91129564
70SIK30.90204783
71CDK90.90168860
72TEC0.90137649
73LMTK20.84794991
74GRK70.84462762
75CSNK1G30.84006208
76ADRBK20.83808830
77WNK40.83509926
78MET0.82750136
79SGK4940.81443174
80SGK2230.81443174
81PDPK10.80312571
82FES0.79296869
83MAP3K30.79069233
84RET0.77061114
85PRKCZ0.76851907
86TRIB30.75758363
87JAK20.75376851
88ACVR1B0.74256295
89MST1R0.72826992
90MAPK110.69880520
91CSNK1G10.68221706
92CSNK1A1L0.67732029
93NTRK20.67329834
94PDK10.67116036
95MAPKAPK30.66965076
96SGK10.66029533
97CDK50.65714762
98CDK190.65097711
99PDGFRA0.64766889
100PAK30.64177349
101FER0.63983797
102PTK60.62313827
103PKN10.62006808
104JAK10.61940490
105STK110.61331590
106MAPKAPK50.60529114
107NTRK10.60229391
108TAOK30.59222584
109DYRK20.59118147
110NEK60.58734174
111CAMK2A0.58645056
112PRKACG0.57638373
113DYRK1A0.57335955
114IRAK20.56376003
115TIE10.54681881
116UHMK10.52761875
117MAP2K10.52017442
118NUAK10.50919398
119TGFBR20.50650718
120TNIK0.49275677
121PIK3CA0.48896933
122PRKG10.48103464
123MTOR0.47740153
124RAF10.47631830
125MAP3K50.47029979
126MAPK120.46926117
127RPS6KA30.44291238
128MAP3K60.43283199
129EIF2AK20.41935671
130IKBKE0.41553701
131ARAF0.40000085
132IKBKB0.38809268
133PRKACB0.37469215
134ERBB20.36400815
135GRK10.36322376
136SIK20.36072592
137PRKD10.35593483
138BCR0.35287729
139FGFR10.35212793
140CSNK1D0.35023056
141EGFR0.34757660
142STK160.34463793
143STK240.34163825
144PTK2B0.34062721
145MAPK100.33579247
146IRAK30.32791280
147PRKACA0.32560946
148NLK0.32499155
149AKT20.32481607
150CDK60.32399145
151STK30.31759492
152ABL10.31526017
153RPS6KB10.31155180
154FGFR30.30844071
155PRKCG0.30385499
156GSK3A0.29920911
157ERN10.29873774
158CAMKK10.29101489
159CAMK40.28998010

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.88407527
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.56734289
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17934793
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.92368776
5Fatty acid degradation_Homo sapiens_hsa000712.90778642
6Propanoate metabolism_Homo sapiens_hsa006402.87128593
7Arginine biosynthesis_Homo sapiens_hsa002202.70718291
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57746417
9Butanoate metabolism_Homo sapiens_hsa006502.54236598
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51491035
11Tryptophan metabolism_Homo sapiens_hsa003802.45776380
12Protein export_Homo sapiens_hsa030602.43382194
13Fatty acid metabolism_Homo sapiens_hsa012122.35478088
14PPAR signaling pathway_Homo sapiens_hsa033202.28891471
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26570790
16Rheumatoid arthritis_Homo sapiens_hsa053232.07433612
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04275564
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03382462
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.97698298
20Complement and coagulation cascades_Homo sapiens_hsa046101.93576279
21beta-Alanine metabolism_Homo sapiens_hsa004101.93473507
22Collecting duct acid secretion_Homo sapiens_hsa049661.92533919
23Peroxisome_Homo sapiens_hsa041461.91024926
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88074113
25Synaptic vesicle cycle_Homo sapiens_hsa047211.83655810
26Legionellosis_Homo sapiens_hsa051341.75403285
27Caffeine metabolism_Homo sapiens_hsa002321.74929682
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66164784
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62798423
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60967737
31Pyruvate metabolism_Homo sapiens_hsa006201.58854767
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57704767
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52052535
34Phototransduction_Homo sapiens_hsa047441.51964621
35Dopaminergic synapse_Homo sapiens_hsa047281.50266557
36Phenylalanine metabolism_Homo sapiens_hsa003601.46717204
37Fatty acid biosynthesis_Homo sapiens_hsa000611.44950024
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.44077672
39Bile secretion_Homo sapiens_hsa049761.43075705
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42758812
41Glutamatergic synapse_Homo sapiens_hsa047241.40406400
42Amphetamine addiction_Homo sapiens_hsa050311.40188085
43Carbon metabolism_Homo sapiens_hsa012001.40029816
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.37790788
45Cocaine addiction_Homo sapiens_hsa050301.35639069
46Circadian entrainment_Homo sapiens_hsa047131.34308489
47Selenocompound metabolism_Homo sapiens_hsa004501.33388847
48Chemical carcinogenesis_Homo sapiens_hsa052041.33043550
49Histidine metabolism_Homo sapiens_hsa003401.31820365
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31103547
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30528443
52Retinol metabolism_Homo sapiens_hsa008301.26023667
53Starch and sucrose metabolism_Homo sapiens_hsa005001.24047468
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23595200
55Fatty acid elongation_Homo sapiens_hsa000621.23200462
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22009395
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21386177
58Tyrosine metabolism_Homo sapiens_hsa003501.19007268
59Glycerolipid metabolism_Homo sapiens_hsa005611.18700325
60Phagosome_Homo sapiens_hsa041451.18613901
61Staphylococcus aureus infection_Homo sapiens_hsa051501.17006502
62ABC transporters_Homo sapiens_hsa020101.15244135
63Type I diabetes mellitus_Homo sapiens_hsa049401.14122112
64Biosynthesis of amino acids_Homo sapiens_hsa012301.12791338
65Drug metabolism - other enzymes_Homo sapiens_hsa009831.10770052
66Sulfur metabolism_Homo sapiens_hsa009201.09276519
67SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07697771
68Fat digestion and absorption_Homo sapiens_hsa049751.06466963
69Tuberculosis_Homo sapiens_hsa051521.02675722
70Pertussis_Homo sapiens_hsa051331.00495874
71Serotonergic synapse_Homo sapiens_hsa047260.99880301
72Long-term depression_Homo sapiens_hsa047300.98201151
73Lysine degradation_Homo sapiens_hsa003100.97300146
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96585452
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.96052844
76Olfactory transduction_Homo sapiens_hsa047400.94170536
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.93759894
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91484041
79Taste transduction_Homo sapiens_hsa047420.91393120
80Asthma_Homo sapiens_hsa053100.89941661
81Vitamin B6 metabolism_Homo sapiens_hsa007500.88606632
82Salmonella infection_Homo sapiens_hsa051320.88344776
83Vibrio cholerae infection_Homo sapiens_hsa051100.86793348
84Oxidative phosphorylation_Homo sapiens_hsa001900.86380033
85cAMP signaling pathway_Homo sapiens_hsa040240.86178421
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84536515
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84380855
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84268739
89Cholinergic synapse_Homo sapiens_hsa047250.84087799
90African trypanosomiasis_Homo sapiens_hsa051430.82149346
91Ether lipid metabolism_Homo sapiens_hsa005650.82010058
92Malaria_Homo sapiens_hsa051440.81439626
93Vitamin digestion and absorption_Homo sapiens_hsa049770.75779135
94Arginine and proline metabolism_Homo sapiens_hsa003300.75404055
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73564992
96Osteoclast differentiation_Homo sapiens_hsa043800.72527286
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72008140
98Salivary secretion_Homo sapiens_hsa049700.71875012
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.71446029
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71214874
101TNF signaling pathway_Homo sapiens_hsa046680.70220546
102Lysosome_Homo sapiens_hsa041420.69894118
103Long-term potentiation_Homo sapiens_hsa047200.69408545
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69074479
105Insulin resistance_Homo sapiens_hsa049310.68625068
106Oxytocin signaling pathway_Homo sapiens_hsa049210.67434661
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67359437
108Sphingolipid metabolism_Homo sapiens_hsa006000.66131085
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65989533
110Glucagon signaling pathway_Homo sapiens_hsa049220.65428579
111Graft-versus-host disease_Homo sapiens_hsa053320.64961644
112Mineral absorption_Homo sapiens_hsa049780.64022388
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.63374426
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62705915
115Folate biosynthesis_Homo sapiens_hsa007900.62551987
116AMPK signaling pathway_Homo sapiens_hsa041520.62365781
117Estrogen signaling pathway_Homo sapiens_hsa049150.59433329
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58791264
119Type II diabetes mellitus_Homo sapiens_hsa049300.53572425
120Ras signaling pathway_Homo sapiens_hsa040140.53457324
121Leishmaniasis_Homo sapiens_hsa051400.52901889
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50951763
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.50756892
124Toxoplasmosis_Homo sapiens_hsa051450.49609869
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49431860
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49010606
127Parkinsons disease_Homo sapiens_hsa050120.48887227
128Steroid biosynthesis_Homo sapiens_hsa001000.48742490
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.47298883
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.47086360
131MAPK signaling pathway_Homo sapiens_hsa040100.46801402
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45452953
133FoxO signaling pathway_Homo sapiens_hsa040680.45185603
134Cardiac muscle contraction_Homo sapiens_hsa042600.44990476
135Systemic lupus erythematosus_Homo sapiens_hsa053220.44599466
136Influenza A_Homo sapiens_hsa051640.44170141
137Renal cell carcinoma_Homo sapiens_hsa052110.43371561
138Alzheimers disease_Homo sapiens_hsa050100.42723797
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42232555
140Gap junction_Homo sapiens_hsa045400.41920514
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41633692
142Pentose phosphate pathway_Homo sapiens_hsa000300.41340062
143Insulin signaling pathway_Homo sapiens_hsa049100.39709407
144One carbon pool by folate_Homo sapiens_hsa006700.39052581
145Prion diseases_Homo sapiens_hsa050200.32702722
146Metabolic pathways_Homo sapiens_hsa011000.32278780
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27860914
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26673120
149Fructose and mannose metabolism_Homo sapiens_hsa000510.24630870
150Nicotine addiction_Homo sapiens_hsa050330.23112333
151Glutathione metabolism_Homo sapiens_hsa004800.22985517
152Ovarian steroidogenesis_Homo sapiens_hsa049130.17736689
153GABAergic synapse_Homo sapiens_hsa047270.16133427
154Insulin secretion_Homo sapiens_hsa049110.15244725
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14843431
156Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14421125
157Dorso-ventral axis formation_Homo sapiens_hsa043200.13903122
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13241254
159Sulfur relay system_Homo sapiens_hsa041220.12503111
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.12465701
161Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10469679
162Linoleic acid metabolism_Homo sapiens_hsa005910.09930386
163Aldosterone synthesis and secretion_Homo sapiens_hsa049250.09660843
164Circadian rhythm_Homo sapiens_hsa047100.08986933
165Galactose metabolism_Homo sapiens_hsa000520.07034599
166mTOR signaling pathway_Homo sapiens_hsa041500.05874063
167Renin secretion_Homo sapiens_hsa049240.05387579
168Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04623411
169Morphine addiction_Homo sapiens_hsa050320.02533379
170Calcium signaling pathway_Homo sapiens_hsa040200.00877906
171Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.00485752
172Regulation of autophagy_Homo sapiens_hsa04140-0.0115143

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