PNPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)6.81691426
2L-phenylalanine catabolic process (GO:0006559)6.67640280
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.67640280
4L-phenylalanine metabolic process (GO:0006558)6.49859761
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.49859761
6protoporphyrinogen IX biosynthetic process (GO:0006782)6.41746961
7aromatic amino acid family catabolic process (GO:0009074)6.06952421
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.63157655
9sulfur amino acid catabolic process (GO:0000098)5.57309393
10tryptophan catabolic process (GO:0006569)5.54897854
11indole-containing compound catabolic process (GO:0042436)5.54897854
12indolalkylamine catabolic process (GO:0046218)5.54897854
13kynurenine metabolic process (GO:0070189)5.41439492
14glyoxylate metabolic process (GO:0046487)5.33652538
15cysteine metabolic process (GO:0006534)5.31196353
16tryptophan metabolic process (GO:0006568)5.30693983
17bile acid biosynthetic process (GO:0006699)5.15478048
18urea cycle (GO:0000050)5.04936382
19urea metabolic process (GO:0019627)5.04936382
20high-density lipoprotein particle remodeling (GO:0034375)5.01044790
21negative regulation of fibrinolysis (GO:0051918)4.98178935
22coenzyme catabolic process (GO:0009109)4.93552279
23lysine catabolic process (GO:0006554)4.84552913
24lysine metabolic process (GO:0006553)4.84552913
25regulation of protein activation cascade (GO:2000257)4.69284713
26regulation of fibrinolysis (GO:0051917)4.69020058
27alpha-linolenic acid metabolic process (GO:0036109)4.67550615
28serine family amino acid catabolic process (GO:0009071)4.67163989
29nitrogen cycle metabolic process (GO:0071941)4.63428471
30porphyrin-containing compound biosynthetic process (GO:0006779)4.61764817
31cellular modified amino acid catabolic process (GO:0042219)4.59299105
32complement activation, alternative pathway (GO:0006957)4.59123469
33heme biosynthetic process (GO:0006783)4.55897805
34peptidyl-glutamic acid carboxylation (GO:0017187)4.50162144
35protein carboxylation (GO:0018214)4.50162144
36cofactor catabolic process (GO:0051187)4.47441819
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.47130162
38aromatic amino acid family metabolic process (GO:0009072)4.44155749
39reverse cholesterol transport (GO:0043691)4.42555080
40porphyrin-containing compound metabolic process (GO:0006778)4.39553915
41bile acid metabolic process (GO:0008206)4.36379276
42regulation of complement activation (GO:0030449)4.35709351
43heme transport (GO:0015886)4.34129685
44alpha-amino acid catabolic process (GO:1901606)4.33616522
45homocysteine metabolic process (GO:0050667)4.30886130
46protein-lipid complex remodeling (GO:0034368)4.30657641
47macromolecular complex remodeling (GO:0034367)4.30657641
48plasma lipoprotein particle remodeling (GO:0034369)4.30657641
49regulation of triglyceride catabolic process (GO:0010896)4.29583516
50plasma lipoprotein particle assembly (GO:0034377)4.29219868
51amino-acid betaine metabolic process (GO:0006577)4.28847692
52regulation of cholesterol esterification (GO:0010872)4.28205343
53heme metabolic process (GO:0042168)4.28119077
54glycine metabolic process (GO:0006544)4.26849380
55tyrosine metabolic process (GO:0006570)4.19277936
56respiratory chain complex IV assembly (GO:0008535)4.19175718
57very-low-density lipoprotein particle assembly (GO:0034379)4.16940663
58tetrapyrrole biosynthetic process (GO:0033014)4.16307777
59phospholipid efflux (GO:0033700)4.15981510
60cellular amino acid catabolic process (GO:0009063)4.13867902
61glutamate metabolic process (GO:0006536)4.07252462
62serine family amino acid metabolic process (GO:0009069)4.06852389
63negative regulation of sterol transport (GO:0032372)4.06659011
64negative regulation of cholesterol transport (GO:0032375)4.06659011
65cellular ketone body metabolic process (GO:0046950)4.01740693
66triglyceride homeostasis (GO:0070328)3.98893521
67acylglycerol homeostasis (GO:0055090)3.98893521
68indolalkylamine metabolic process (GO:0006586)3.95833888
69imidazole-containing compound metabolic process (GO:0052803)3.95018932
70branched-chain amino acid catabolic process (GO:0009083)3.93885797
71serine family amino acid biosynthetic process (GO:0009070)3.92810620
72plasma lipoprotein particle clearance (GO:0034381)3.83336347
73amine catabolic process (GO:0009310)3.80709708
74cellular biogenic amine catabolic process (GO:0042402)3.80709708
75cholesterol efflux (GO:0033344)3.78356993
76bile acid and bile salt transport (GO:0015721)3.76902717
77protein-lipid complex assembly (GO:0065005)3.76044170
78pteridine-containing compound biosynthetic process (GO:0042559)3.74436736
79dicarboxylic acid biosynthetic process (GO:0043650)3.74107518
80ethanol oxidation (GO:0006069)3.70957461
81benzene-containing compound metabolic process (GO:0042537)3.70303530
82drug catabolic process (GO:0042737)3.66424333
83arginine metabolic process (GO:0006525)3.64196633
84blood coagulation, intrinsic pathway (GO:0007597)3.63669420
85aldehyde catabolic process (GO:0046185)3.63665256
86plasma lipoprotein particle organization (GO:0071827)3.61019878
87cytochrome complex assembly (GO:0017004)3.58595051
88aspartate family amino acid catabolic process (GO:0009068)3.58194922
89regulation of hexokinase activity (GO:1903299)3.56731671
90regulation of glucokinase activity (GO:0033131)3.56731671
91carboxylic acid catabolic process (GO:0046395)3.54342509
92organic acid catabolic process (GO:0016054)3.54342509
93epoxygenase P450 pathway (GO:0019373)3.54192895
942-oxoglutarate metabolic process (GO:0006103)3.51665436
95positive regulation of glycolytic process (GO:0045821)3.50405701
96drug metabolic process (GO:0017144)3.50271238
97exogenous drug catabolic process (GO:0042738)3.48178112
98flavonoid metabolic process (GO:0009812)3.45285320
99positive regulation of triglyceride lipase activity (GO:0061365)3.44797841
100positive regulation of lipoprotein lipase activity (GO:0051006)3.44797841
101oxaloacetate metabolic process (GO:0006107)3.44220827
102ketone body metabolic process (GO:1902224)3.42815069
103complement activation, classical pathway (GO:0006958)3.42242135
104xenobiotic catabolic process (GO:0042178)3.41245702
105low-density lipoprotein particle remodeling (GO:0034374)3.39469184
106negative regulation of execution phase of apoptosis (GO:1900118)3.38747396
107valine metabolic process (GO:0006573)3.37454830
108acetyl-CoA metabolic process (GO:0006084)3.37017110
109nicotinamide nucleotide biosynthetic process (GO:0019359)3.35149876
110pyridine nucleotide biosynthetic process (GO:0019363)3.35149876
111amino acid salvage (GO:0043102)3.22366195
112L-methionine salvage (GO:0071267)3.22366195
113L-methionine biosynthetic process (GO:0071265)3.22366195
114branched-chain amino acid metabolic process (GO:0009081)3.16358193
115regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.15630220
116protein complex biogenesis (GO:0070271)3.15553870
117S-adenosylmethionine metabolic process (GO:0046500)3.14131722
118lactate metabolic process (GO:0006089)3.09571557
119pteridine-containing compound metabolic process (GO:0042558)3.02608889
120mitochondrial respiratory chain complex assembly (GO:0033108)3.01419854
121proteasome assembly (GO:0043248)3.01173605
122DNA deamination (GO:0045006)3.00311226
123tetrahydrofolate metabolic process (GO:0046653)2.95545029
124signal peptide processing (GO:0006465)2.95137396
125pseudouridine synthesis (GO:0001522)2.92663816
126mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84350451
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83626639
128oxidative demethylation (GO:0070989)2.82864960
129nitric oxide biosynthetic process (GO:0006809)2.81343260
130peptidyl-histidine modification (GO:0018202)2.81089206
131zinc ion transport (GO:0006829)2.77937048
132methionine biosynthetic process (GO:0009086)2.75184970
133intestinal cholesterol absorption (GO:0030299)2.75047510
134omega-hydroxylase P450 pathway (GO:0097267)2.73690224
135regulation of type B pancreatic cell apoptotic process (GO:2000674)2.72549155
136preassembly of GPI anchor in ER membrane (GO:0016254)2.66172586
137phenylpropanoid metabolic process (GO:0009698)2.64120486
138regulation of cellular amino acid metabolic process (GO:0006521)2.60572801
139endocrine pancreas development (GO:0031018)2.58972471
140negative regulation of acute inflammatory response (GO:0002674)2.58434412
141regulation of mitochondrial translation (GO:0070129)2.57911392
142L-alpha-amino acid transmembrane transport (GO:1902475)2.55697984
143C-terminal protein lipidation (GO:0006501)2.55630009
144glucuronate metabolic process (GO:0019585)2.55512304
145uronic acid metabolic process (GO:0006063)2.55512304
146cellular glucuronidation (GO:0052695)2.55458050
147fatty acid homeostasis (GO:0055089)2.55433590
148mannosylation (GO:0097502)2.54605991
149zinc ion transmembrane transport (GO:0071577)2.54163082
150polyol catabolic process (GO:0046174)2.53776226
151folic acid-containing compound biosynthetic process (GO:0009396)2.51850668
152mitochondrial respiratory chain complex I assembly (GO:0032981)2.48605857
153NADH dehydrogenase complex assembly (GO:0010257)2.48605857
154mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.48605857
155nucleotide transmembrane transport (GO:1901679)2.48284616
156maturation of 5.8S rRNA (GO:0000460)2.47759055
157protein K6-linked ubiquitination (GO:0085020)2.46302132
158cullin deneddylation (GO:0010388)2.45006764
159rRNA modification (GO:0000154)2.44750957
160aspartate family amino acid biosynthetic process (GO:0009067)2.44289217
161electron transport chain (GO:0022900)2.42819403
162establishment of protein localization to mitochondrial membrane (GO:0090151)2.42150707
163folic acid-containing compound metabolic process (GO:0006760)2.41707168
164quinone metabolic process (GO:1901661)2.41536077
165organic cation transport (GO:0015695)2.38600700
166negative regulation of neurological system process (GO:0031645)2.38455310
167respiratory electron transport chain (GO:0022904)2.37008143
168negative regulation of protein activation cascade (GO:2000258)2.36298161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.94761608
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.79292444
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.03903135
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.58142389
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.03969309
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61359979
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.42452569
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.35471166
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.14380099
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.72012943
11GATA1_22025678_ChIP-Seq_K562_Human3.48585439
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.16880637
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.15426189
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94730276
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.58737524
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43465205
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34211896
18ZNF274_21170338_ChIP-Seq_K562_Hela2.19454922
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.11524142
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.01459729
21* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99153125
22ELK1_19687146_ChIP-ChIP_HELA_Human1.93810988
23* VDR_23849224_ChIP-Seq_CD4+_Human1.87969517
24GATA1_19941826_ChIP-Seq_K562_Human1.86650279
25VDR_22108803_ChIP-Seq_LS180_Human1.86240488
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.70913229
27* GATA1_19941827_ChIP-Seq_MEL_Mouse1.69047978
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68932383
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66836628
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65922022
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63164013
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63106166
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.62477291
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.61182069
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60100784
36DCP1A_22483619_ChIP-Seq_HELA_Human1.53515673
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52344347
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51822383
39* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51643877
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48296998
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45030691
42TP53_22573176_ChIP-Seq_HFKS_Human1.43247310
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42012482
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41885938
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39195660
46KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.36418287
47SCL_19346495_ChIP-Seq_HPC-7_Human1.36298267
48ER_23166858_ChIP-Seq_MCF-7_Human1.35102210
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31685910
50GABP_19822575_ChIP-Seq_HepG2_Human1.28299027
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28092858
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23589303
53AR_20517297_ChIP-Seq_VCAP_Human1.22946990
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22251228
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20045571
56MYC_18940864_ChIP-ChIP_HL60_Human1.17753391
57* TFEB_21752829_ChIP-Seq_HELA_Human1.17336719
58* FOXA1_25329375_ChIP-Seq_VCAP_Human1.16425432
59* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16425432
60GATA2_19941826_ChIP-Seq_K562_Human1.16036712
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15996342
62* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15002593
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13566097
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13044363
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12976679
66* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12803185
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07246459
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06653087
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04396815
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02594760
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02108546
72IRF1_19129219_ChIP-ChIP_H3396_Human1.01616154
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01290186
74NCOR_22424771_ChIP-Seq_293T_Human1.00719181
75FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00528806
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.00479637
77CDX2_22108803_ChIP-Seq_LS180_Human1.00320620
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98766273
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98766273
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98766273
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97508758
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97495929
83FOXA2_19822575_ChIP-Seq_HepG2_Human0.97065208
84HOXB7_26014856_ChIP-Seq_BT474_Human0.96829209
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96434338
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95976068
87HTT_18923047_ChIP-ChIP_STHdh_Human0.95454233
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95422390
89IGF1R_20145208_ChIP-Seq_DFB_Human0.95325062
90NANOG_19829295_ChIP-Seq_ESCs_Human0.93685555
91SOX2_19829295_ChIP-Seq_ESCs_Human0.93685555
92E2F7_22180533_ChIP-Seq_HELA_Human0.93675591
93GATA3_24758297_ChIP-Seq_MCF-7_Human0.93593115
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.91013238
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90793075
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90487335
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90174452
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.90073379
99* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89229314
100* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89178960
101CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88677827
102SOX2_20726797_ChIP-Seq_SW620_Human0.88177065
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.87366899
104ELF1_20517297_ChIP-Seq_JURKAT_Human0.85419527
105CRX_20693478_ChIP-Seq_RETINA_Mouse0.85347840
106FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84680687
107STAT3_18555785_Chip-Seq_ESCs_Mouse0.84354127
108ELF5_23300383_ChIP-Seq_T47D_Human0.83600819
109PHF8_20622853_ChIP-Seq_HELA_Human0.82809382
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82737296
111LXR_22292898_ChIP-Seq_THP-1_Human0.82104419
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81574543
113* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.81425614
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81319222
115* FOXH1_21741376_ChIP-Seq_EPCs_Human0.80528665
116* SRF_21415370_ChIP-Seq_HL-1_Mouse0.80166541
117CLOCK_20551151_ChIP-Seq_293T_Human0.79905158
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79669748
119BCL6_27268052_Chip-Seq_Bcells_Human0.78600021
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78550715
121TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78043552
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77559607
123GATA3_21878914_ChIP-Seq_MCF-7_Human0.77403373
124BCOR_27268052_Chip-Seq_Bcells_Human0.77198998
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77143188
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77066644
127CBP_20019798_ChIP-Seq_JUKART_Human0.76871719
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76513570
129E2F1_18555785_ChIP-Seq_MESCs_Mouse0.74701471
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74338402
131RARB_24833708_ChIP-Seq_LIVER_Mouse0.74310415
132LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.73712874
133GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71961842
134ZNF263_19887448_ChIP-Seq_K562_Human0.71898687
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71783687
136OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71240549
137NCOR1_26117541_ChIP-Seq_K562_Human0.71236318
138CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70584718
139JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.70066601
140GATA4_25053715_ChIP-Seq_YYC3_Human0.69091312
141CTCF_21964334_Chip-Seq_Bcells_Human0.67153678
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.66977120
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.65057009
144IRF8_22096565_ChIP-ChIP_GC-B_Human0.64847178
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.63918455
146GATA6_25053715_ChIP-Seq_YYC3_Human0.63347607
147MYC_22102868_ChIP-Seq_BL_Human0.62969624
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.62758215
149ELF1_17652178_ChIP-ChIP_JURKAT_Human0.61042238
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.60777993
151FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.60180499
152KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.58743332
153P68_20966046_ChIP-Seq_HELA_Human0.58720559
154* FOXP3_21729870_ChIP-Seq_TREG_Human0.58192828
155SPI1_20517297_ChIP-Seq_HL60_Human0.58175999
156LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.57973341
157KDM5A_27292631_Chip-Seq_BREAST_Human0.57931490
158BRD4_27068464_Chip-Seq_AML-cells_Mouse0.57662291
159FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.56324122
160SPI1_26923725_Chip-Seq_HPCs_Mouse0.55833949
161E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.55584129
162FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.55465204
163SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.55293519
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54453237
165PHF8_20622854_ChIP-Seq_HELA_Human0.53587570
166NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.53545992
167ERG_20517297_ChIP-Seq_VCAP_Human0.53188207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.41144490
2MP0005360_urolithiasis6.76414432
3MP0005085_abnormal_gallbladder_physiolo5.82434291
4MP0005365_abnormal_bile_salt5.50369521
5MP0008875_abnormal_xenobiotic_pharmacok4.76705273
6MP0003656_abnormal_erythrocyte_physiolo4.37524390
7MP0003806_abnormal_nucleotide_metabolis3.89558173
8MP0005083_abnormal_biliary_tract3.48131308
9MP0010329_abnormal_lipoprotein_level3.30832379
10MP0010234_abnormal_vibrissa_follicle3.22226208
11MP0003252_abnormal_bile_duct3.20234411
12MP0005379_endocrine/exocrine_gland_phen3.13510403
13MP0004147_increased_porphyrin_level3.07159702
14MP0009780_abnormal_chondrocyte_physiolo2.89446329
15MP0002163_abnormal_gland_morphology2.77355718
16MP0009840_abnormal_foam_cell2.71538825
17MP0005332_abnormal_amino_acid2.52301129
18MP0001666_abnormal_nutrient_absorption2.43613261
19MP0003191_abnormal_cellular_cholesterol2.41113067
20MP0003195_calcinosis2.34192630
21MP0003011_delayed_dark_adaptation2.22950290
22MP0000609_abnormal_liver_physiology2.22050316
23MP0005319_abnormal_enzyme/_coenzyme1.98008338
24MP0003950_abnormal_plasma_membrane1.95348307
25MP0005646_abnormal_pituitary_gland1.88968380
26MP0002118_abnormal_lipid_homeostasis1.87284710
27MP0002693_abnormal_pancreas_physiology1.86381059
28MP0004019_abnormal_vitamin_homeostasis1.85799160
29MP0001764_abnormal_homeostasis1.82208949
30MP0002138_abnormal_hepatobiliary_system1.80016698
31MP0006036_abnormal_mitochondrial_physio1.77294440
32MP0004264_abnormal_extraembryonic_tissu1.74477867
33MP0005645_abnormal_hypothalamus_physiol1.73684006
34MP0001944_abnormal_pancreas_morphology1.70677767
35MP0003186_abnormal_redox_activity1.70149677
36MP0005584_abnormal_enzyme/coenzyme_acti1.68761159
37MP0002909_abnormal_adrenal_gland1.67987382
38MP0005636_abnormal_mineral_homeostasis1.67239717
39MP0002254_reproductive_system_inflammat1.60541660
40MP0003868_abnormal_feces_composition1.56585942
41MP0006035_abnormal_mitochondrial_morpho1.51709381
42MP0002166_altered_tumor_susceptibility1.45899478
43MP0009643_abnormal_urine_homeostasis1.41129777
44MP0000372_irregular_coat_pigmentation1.39107575
45MP0000427_abnormal_hair_cycle1.34323470
46MP0009697_abnormal_copulation1.32993130
47MP0003786_premature_aging1.30447983
48MP0010386_abnormal_urinary_bladder1.29719404
49MP0000598_abnormal_liver_morphology1.27450179
50MP0002160_abnormal_reproductive_system1.24589109
51MP0005551_abnormal_eye_electrophysiolog1.24114530
52MP0008872_abnormal_physiological_respon1.16842005
53MP0010678_abnormal_skin_adnexa1.13160871
54MP0008775_abnormal_heart_ventricle1.08765959
55MP0005266_abnormal_metabolism1.08729646
56MP0002928_abnormal_bile_duct1.07549188
57MP0003705_abnormal_hypodermis_morpholog1.06993561
58MP0001873_stomach_inflammation1.06315813
59MP0009764_decreased_sensitivity_to1.06016560
60MP0005376_homeostasis/metabolism_phenot1.05726038
61MP0009046_muscle_twitch1.04761457
62MP0003123_paternal_imprinting1.03904945
63MP0003646_muscle_fatigue1.03355398
64MP0002090_abnormal_vision1.01942748
65MP0000013_abnormal_adipose_tissue1.01022129
66MP0009763_increased_sensitivity_to0.99570781
67MP0002006_tumorigenesis0.98664720
68MP0009765_abnormal_xenobiotic_induced0.97639037
69MP0005389_reproductive_system_phenotype0.95956519
70MP0006072_abnormal_retinal_apoptosis0.95636712
71MP0003172_abnormal_lysosome_physiology0.95381743
72MP0005395_other_phenotype0.94350996
73MP0000538_abnormal_urinary_bladder0.92872214
74MP0005410_abnormal_fertilization0.91935255
75MP0008469_abnormal_protein_level0.90748578
76MP0002332_abnormal_exercise_endurance0.90048699
77MP0005464_abnormal_platelet_physiology0.88544234
78MP0009642_abnormal_blood_homeostasis0.87500371
79MP0002132_abnormal_respiratory_system0.85948361
80MP0002078_abnormal_glucose_homeostasis0.85187932
81MP0001984_abnormal_olfaction0.84516042
82MP0008877_abnormal_DNA_methylation0.83127444
83MP0005075_abnormal_melanosome_morpholog0.82467159
84MP0002876_abnormal_thyroid_physiology0.81460098
85MP0004043_abnormal_pH_regulation0.81023043
86MP0008007_abnormal_cellular_replicative0.80733110
87MP0000015_abnormal_ear_pigmentation0.78898194
88MP0002102_abnormal_ear_morphology0.77163880
89MP0001881_abnormal_mammary_gland0.77102898
90MP0002822_catalepsy0.76748304
91MP0000516_abnormal_urinary_system0.76403059
92MP0005367_renal/urinary_system_phenotyp0.76403059
93MP0005647_abnormal_sex_gland0.76154440
94MP0003943_abnormal_hepatobiliary_system0.75908363
95MP0000604_amyloidosis0.74817500
96MP0001756_abnormal_urination0.73513137
97MP0005174_abnormal_tail_pigmentation0.72263060
98MP0005451_abnormal_body_composition0.72231550
99MP0005535_abnormal_body_temperature0.71916528
100MP0001905_abnormal_dopamine_level0.71694283
101MP0010352_gastrointestinal_tract_polyps0.70664837
102MP0003787_abnormal_imprinting0.70284072
103MP0002168_other_aberrant_phenotype0.70244474
104MP0000371_diluted_coat_color0.65775592
105MP0000613_abnormal_salivary_gland0.63743444
106MP0008058_abnormal_DNA_repair0.63737905
107MP0002970_abnormal_white_adipose0.62118221
108MP0005448_abnormal_energy_balance0.61825433
109MP0005084_abnormal_gallbladder_morpholo0.61742817
110MP0008873_increased_physiological_sensi0.61020052
111MP0005334_abnormal_fat_pad0.58048312
112MP0006082_CNS_inflammation0.53395640
113MP0000639_abnormal_adrenal_gland0.52306042
114MP0002136_abnormal_kidney_physiology0.51614637
115MP0008874_decreased_physiological_sensi0.50204742
116MP0001765_abnormal_ion_homeostasis0.48856159
117MP0004130_abnormal_muscle_cell0.48086188
118MP0004782_abnormal_surfactant_physiolog0.47815257
119MP0010368_abnormal_lymphatic_system0.46850726
120MP0002971_abnormal_brown_adipose0.46014340
121MP0005220_abnormal_exocrine_pancreas0.44276465
122MP0002837_dystrophic_cardiac_calcinosis0.43854811
123MP0003075_altered_response_to0.43478007
124MP0003953_abnormal_hormone_level0.42706488
125MP0003436_decreased_susceptibility_to0.41877248
126MP0008961_abnormal_basal_metabolism0.40576516
127MP0003638_abnormal_response/metabolism_0.38138970
128MP0001545_abnormal_hematopoietic_system0.38106046
129MP0005397_hematopoietic_system_phenotyp0.38106046
130MP0000358_abnormal_cell_content/0.37829065
131MP0000689_abnormal_spleen_morphology0.36450741
132MP0001845_abnormal_inflammatory_respons0.35333822
133MP0009672_abnormal_birth_weight0.34290171
134MP0005670_abnormal_white_adipose0.34112314
135MP0009931_abnormal_skin_appearance0.33775607
136MP0003890_abnormal_embryonic-extraembry0.33573394
137MP0005452_abnormal_adipose_tissue0.32538906
138MP0009115_abnormal_fat_cell0.31732110
139MP0005408_hypopigmentation0.29010029
140MP0004883_abnormal_blood_vessel0.28689084
141MP0003718_maternal_effect0.28352085
142MP0000230_abnormal_systemic_arterial0.28319114
143MP0001661_extended_life_span0.27760847
144MP0003122_maternal_imprinting0.27705414
145MP0005499_abnormal_olfactory_system0.27592894
146MP0005394_taste/olfaction_phenotype0.27592894
147MP0003329_amyloid_beta_deposits0.26328554
148MP0004142_abnormal_muscle_tone0.26165808
149MP0009053_abnormal_anal_canal0.26061076
150MP0002135_abnormal_kidney_morphology0.25996547

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.57402534
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.91197420
3Intrahepatic cholestasis (HP:0001406)5.71749192
4Deep venous thrombosis (HP:0002625)5.55430196
5Abnormality of the heme biosynthetic pathway (HP:0010472)5.33484300
6Poikilocytosis (HP:0004447)5.32888511
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.24022913
8Hypobetalipoproteinemia (HP:0003563)5.20331513
9Xanthomatosis (HP:0000991)5.04111175
10Prolonged partial thromboplastin time (HP:0003645)5.00273900
11Acanthocytosis (HP:0001927)4.94584823
12Hyperbilirubinemia (HP:0002904)4.49348056
13Complement deficiency (HP:0004431)4.40593920
14Cholelithiasis (HP:0001081)4.23701240
15Hyperlipoproteinemia (HP:0010980)4.16644368
16Abnormal gallbladder morphology (HP:0012437)4.06217542
17Hyperammonemia (HP:0001987)3.99298470
18Reticulocytosis (HP:0001923)3.99159835
19Joint hemorrhage (HP:0005261)3.88770845
20Hypolipoproteinemia (HP:0010981)3.84623878
21Abnormality of the intrinsic pathway (HP:0010989)3.79208855
22Large for gestational age (HP:0001520)3.74339943
23Ketosis (HP:0001946)3.70563006
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.55101495
25Progressive macrocephaly (HP:0004481)3.51814615
26Abnormal gallbladder physiology (HP:0012438)3.49464484
27Cholecystitis (HP:0001082)3.49464484
28Hyperglycinuria (HP:0003108)3.49457795
29Acute necrotizing encephalopathy (HP:0006965)3.48435295
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.46722709
31Abnormality of the common coagulation pathway (HP:0010990)3.44138653
32Acute encephalopathy (HP:0006846)3.43167766
33Hyperglycinemia (HP:0002154)3.38976028
34Abnormality of methionine metabolism (HP:0010901)3.37468056
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.35375038
36Hyperglycemia (HP:0003074)3.31645133
37Abnormality of serine family amino acid metabolism (HP:0010894)3.29880620
38Abnormality of glycine metabolism (HP:0010895)3.29880620
39Abnormality of glutamine family amino acid metabolism (HP:0010902)3.27967005
40Hypoalphalipoproteinemia (HP:0003233)3.26824558
41Hypoglycemic coma (HP:0001325)3.26115246
42Abnormality of complement system (HP:0005339)3.23562512
43Fat malabsorption (HP:0002630)3.22579383
44Abnormality of pyrimidine metabolism (HP:0004353)3.22552996
45Hypothermia (HP:0002045)3.21632861
46Increased CSF lactate (HP:0002490)3.17694911
47Hepatocellular carcinoma (HP:0001402)3.17291412
48Hepatic necrosis (HP:0002605)3.16875866
49Mitochondrial inheritance (HP:0001427)3.14586185
50Epidermoid cyst (HP:0200040)3.10770265
51Abnormal mitochondria in muscle tissue (HP:0008316)3.09663124
52Gout (HP:0001997)3.06515342
53Hypochromic anemia (HP:0001931)3.03791287
54Abnormality of the gallbladder (HP:0005264)3.01439436
55Hamartoma of the eye (HP:0010568)3.00309700
56Conjunctival hamartoma (HP:0100780)2.99835602
57Abnormality of fatty-acid metabolism (HP:0004359)2.82592377
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82332495
59* Metabolic acidosis (HP:0001942)2.80869378
60Lipid accumulation in hepatocytes (HP:0006561)2.79381238
61Ketoacidosis (HP:0001993)2.78900708
62Hypercholesterolemia (HP:0003124)2.78350477
63Hepatocellular necrosis (HP:0001404)2.74729641
64Vascular calcification (HP:0004934)2.74678268
65Abnormality of nucleobase metabolism (HP:0010932)2.70463174
66Conjugated hyperbilirubinemia (HP:0002908)2.64873118
67Increased hepatocellular lipid droplets (HP:0006565)2.64520072
68Hyperinsulinemic hypoglycemia (HP:0000825)2.63806286
69Tongue fasciculations (HP:0001308)2.62659439
70Glycosuria (HP:0003076)2.61446092
71Abnormality of urine glucose concentration (HP:0011016)2.61446092
72Paralysis (HP:0003470)2.60137882
73Skin nodule (HP:0200036)2.60031998
74Ragged-red muscle fibers (HP:0003200)2.56201374
75Hypokinesia (HP:0002375)2.55789112
76Lethargy (HP:0001254)2.54196061
77Neoplasm of the adrenal gland (HP:0100631)2.53645469
78Renal Fanconi syndrome (HP:0001994)2.52729409
79Methylmalonic acidemia (HP:0002912)2.51918084
80Microcytic anemia (HP:0001935)2.50735264
81Spontaneous abortion (HP:0005268)2.50194559
82Abnormality of endocrine pancreas physiology (HP:0012093)2.49775586
83Abnormality of the pancreatic islet cells (HP:0006476)2.49775586
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48081898
85Dicarboxylic aciduria (HP:0003215)2.48081898
86Neoplasm of the adrenal cortex (HP:0100641)2.48067138
87Status epilepticus (HP:0002133)2.45818156
88Abnormality of iron homeostasis (HP:0011031)2.44785112
89Abnormality of purine metabolism (HP:0004352)2.44418263
90Malnutrition (HP:0004395)2.43430223
91Lactic acidosis (HP:0003128)2.42508757
92* Increased serum lactate (HP:0002151)2.40386486
93Abnormality of serum amino acid levels (HP:0003112)2.39758157
94Delayed CNS myelination (HP:0002188)2.39127775
95Abnormality of transition element cation homeostasis (HP:0011030)2.38073065
96Cerebral edema (HP:0002181)2.37954345
97Steatorrhea (HP:0002570)2.37623163
98Abnormality of vitamin B metabolism (HP:0004340)2.35958846
99Vomiting (HP:0002013)2.35327635
100Abnormal cartilage morphology (HP:0002763)2.31810614
101Systemic lupus erythematosus (HP:0002725)2.31404130
102Abnormality of reticulocytes (HP:0004312)2.30502608
103Pancreatic islet-cell hyperplasia (HP:0004510)2.29869433
104Increased serum ferritin (HP:0003281)2.28273404
105Irritability (HP:0000737)2.27792188
106Cardiovascular calcification (HP:0011915)2.27508475
107Pancreatic cysts (HP:0001737)2.27376705
108Congenital stationary night blindness (HP:0007642)2.27209951
109Respiratory failure (HP:0002878)2.27136533
110Late onset (HP:0003584)2.25931521
111Multiple enchondromatosis (HP:0005701)2.24875146
112Abnormality of vitamin metabolism (HP:0100508)2.24489959
1133-Methylglutaconic aciduria (HP:0003535)2.19898783
114Hypomagnesemia (HP:0002917)2.17013943
115Methylmalonic aciduria (HP:0012120)2.15854812
116Osteomalacia (HP:0002749)2.14727479
117Abnormality of the renal cortex (HP:0011035)2.14501979
118Spastic diplegia (HP:0001264)2.13055745
119Rickets (HP:0002748)2.12645346
120Abnormality of the lower motor neuron (HP:0002366)2.12386237
121Cutaneous melanoma (HP:0012056)2.11276889
122Symptomatic seizures (HP:0011145)2.11014056
123Sensorimotor neuropathy (HP:0007141)2.09413814
124Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08800983
125Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08800983
126Insulin-resistant diabetes mellitus (HP:0000831)2.08316315
127Brushfield spots (HP:0001088)2.08030469
128Hypoglycemic seizures (HP:0002173)2.06243441
129Testicular atrophy (HP:0000029)2.04852907
130Gingival bleeding (HP:0000225)2.04436327
131Furrowed tongue (HP:0000221)2.01773160
132Muscle fibrillation (HP:0010546)2.01642798
133Proximal tubulopathy (HP:0000114)2.01394360
134Nausea (HP:0002018)2.00310220
135Ileus (HP:0002595)1.98624461
136Vacuolated lymphocytes (HP:0001922)1.98306703
137Glomerulonephritis (HP:0000099)1.96300495
138Renal cortical cysts (HP:0000803)1.94278553
139Hepatoblastoma (HP:0002884)1.93871335
140Generalized aminoaciduria (HP:0002909)1.91631071
141Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90649090
142Amyloidosis (HP:0011034)1.90034818
143Reduced antithrombin III activity (HP:0001976)1.89720357
144Neonatal onset (HP:0003623)1.89678837
145Thrombophlebitis (HP:0004418)1.89678619
146Myocardial infarction (HP:0001658)1.89094150
147Abnormality of glycolysis (HP:0004366)1.88904142
148Increased serum pyruvate (HP:0003542)1.88904142
149Hyperphosphaturia (HP:0003109)1.88297560
150Neuroendocrine neoplasm (HP:0100634)1.87629186
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87624357
152Abnormality of alanine metabolism (HP:0010916)1.87624357
153Hyperalaninemia (HP:0003348)1.87624357
154Severe muscular hypotonia (HP:0006829)1.87475229
155Tubular atrophy (HP:0000092)1.86203885
156Exercise intolerance (HP:0003546)1.85799291
157Hyperventilation (HP:0002883)1.85423801
158Type I transferrin isoform profile (HP:0003642)1.85218910
159Polycythemia (HP:0001901)1.84956892
160Menorrhagia (HP:0000132)1.84466650
161Recurrent gram-negative bacterial infections (HP:0005420)1.83969243
162Pheochromocytoma (HP:0002666)1.83654006
163Aplasia/Hypoplasia of the fovea (HP:0008060)1.82548225
164Hypoplasia of the fovea (HP:0007750)1.82548225
165Enlarged penis (HP:0000040)1.82361379
166Abnormality of proline metabolism (HP:0010907)1.82282241
167Hydroxyprolinuria (HP:0003080)1.82282241
168Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82074045
169Abnormal protein N-linked glycosylation (HP:0012347)1.82074045
170Abnormal protein glycosylation (HP:0012346)1.82074045
171Abnormal glycosylation (HP:0012345)1.82074045
172Hemiparesis (HP:0001269)1.81685833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.45419781
2ERN15.29760520
3BCKDK5.27509526
4GRK64.15591463
5EIF2AK13.82318425
6MST43.81323978
7GRK53.61671422
8CDK123.56124348
9EIF2AK33.16845259
10MAP2K42.74623840
11TAOK32.50474884
12VRK22.25046645
13FGFR22.11895457
14FLT32.11551004
15STK392.08887914
16MAP4K22.08755677
17FGFR42.02734783
18TSSK62.00534433
19TGFBR21.96633932
20PHKG11.91653149
21PHKG21.91653149
22MAPK111.85404514
23WNK41.85299365
24CSF1R1.83829535
25SIK11.82025613
26BMPR1B1.81450384
27FER1.77030732
28ADRBK21.76685470
29GRK71.71655690
30ZAK1.70817040
31PKN21.68716615
32ACVR1B1.63695042
33GRK11.63373142
34NUAK11.62986261
35TRIM281.62643267
36ERBB41.55224417
37INSRR1.52136550
38TAF11.50066276
39STK241.38954675
40PBK1.38210507
41NME11.34740288
42MAP3K111.33327634
43MAP2K61.33270795
44MAP2K31.32805470
45PLK31.32172263
46PAK31.28553020
47FGFR31.28408410
48STK101.28118495
49EPHA21.26294462
50MAPK71.24869183
51DAPK21.21681148
52TRPM71.19527018
53JAK21.18431765
54BUB11.18430558
55ERBB31.18354029
56PRKCI1.17780885
57MAP3K101.16271896
58MATK1.13439336
59OXSR11.13436734
60MST1R1.07097997
61NEK11.05643171
62IRAK31.04666125
63STK38L1.04509830
64ABL21.04115647
65TTK1.03557900
66MAPKAPK51.00377059
67TRIB30.98558061
68MAPK120.98184972
69LMTK20.96853177
70CSNK1G30.96606614
71PLK20.94819201
72CSNK1G10.93826042
73CAMKK20.93621796
74MAPKAPK30.91564293
75VRK10.91082713
76DAPK10.89950443
77MAP3K120.89946518
78BRSK20.89625117
79TYK20.88777076
80PINK10.88655895
81BRSK10.85283314
82MOS0.84898693
83SYK0.84463998
84LIMK10.84174988
85PRKG20.83282167
86AKT30.79309339
87ERBB20.79271116
88PRKACG0.79233428
89STK30.78105154
90MAP3K20.76731240
91MAP3K70.76449188
92PDK30.75877766
93PDK40.75877766
94EIF2AK20.75341612
95CAMK40.74353421
96PIK3CG0.73329483
97PRKCE0.69581864
98CSNK1A1L0.68976465
99ADRBK10.66058519
100MAP4K10.65219252
101CDK40.65168749
102MUSK0.64947061
103MAPK40.64860509
104KDR0.64406327
105MAP3K30.64295951
106CSNK1G20.63940494
107TAOK10.63336904
108PRKAA20.62699354
109CAMK2D0.61766775
110NME20.61481884
111PRKAA10.59139834
112WNK30.57548864
113AURKA0.53382788
114PDK10.51443086
115ZAP700.50391399
116PIM10.49573052
117TAOK20.49412401
118PIM20.49123693
119STK40.48561784
120PIK3CA0.46705199
121NTRK30.45877824
122TBK10.45129891
123NEK90.43578828
124SIK30.43383951
125NLK0.43213586
126AKT20.42942966
127CSK0.42375407
128SGK30.42203980
129PRKCG0.40334707
130EPHA30.39973245
131MAP2K10.39533028
132MAP3K60.39135537
133MKNK20.38913091
134EEF2K0.38717812
135TNK20.37630577
136KIT0.35529255
137CDK80.35409071
138SCYL20.34853835
139TLK10.34810170
140NTRK10.34670568
141CSNK1A10.34230036
142GSK3A0.33956290
143ILK0.33480336
144PTK2B0.32867288
145MAP3K50.32420721
146RPS6KB20.31160566
147FGFR10.31108972
148TNIK0.30916758
149PDPK10.30482494
150PRKCZ0.29851798
151MYLK0.29441789
152LYN0.29383839
153PAK40.28433558
154STK160.28173236
155CDK70.27667567
156BMPR20.27272207
157PRKCD0.26579684
158IGF1R0.26362916
159PLK10.26262765
160RPS6KB10.25355662
161MET0.25323923
162BRAF0.24937961
163DYRK1B0.24640482
164PTK20.24104947
165CDK60.23920418
166SGK20.21900581
167IKBKB0.21556712
168CHEK20.20315566
169MAP3K10.19983434

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.10273535
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.62415385
3Nitrogen metabolism_Homo sapiens_hsa009103.15218651
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05735141
5Arginine biosynthesis_Homo sapiens_hsa002202.90567561
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.84856466
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68801616
8Tryptophan metabolism_Homo sapiens_hsa003802.62938419
9Complement and coagulation cascades_Homo sapiens_hsa046102.59324432
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.46126772
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38227498
12Protein export_Homo sapiens_hsa030602.38141033
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36882911
14Proteasome_Homo sapiens_hsa030502.35334828
15Fatty acid degradation_Homo sapiens_hsa000712.31079643
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27241664
17Butanoate metabolism_Homo sapiens_hsa006502.03090248
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00477153
19Peroxisome_Homo sapiens_hsa041461.95090041
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94181778
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89652636
22Propanoate metabolism_Homo sapiens_hsa006401.86509045
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81772904
24Chemical carcinogenesis_Homo sapiens_hsa052041.81281047
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80302735
26Pyruvate metabolism_Homo sapiens_hsa006201.78310314
27PPAR signaling pathway_Homo sapiens_hsa033201.66210657
28Selenocompound metabolism_Homo sapiens_hsa004501.64127839
29Histidine metabolism_Homo sapiens_hsa003401.61966173
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.61760110
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.61611461
32beta-Alanine metabolism_Homo sapiens_hsa004101.61181360
33Fatty acid metabolism_Homo sapiens_hsa012121.57162168
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.53739154
35Carbon metabolism_Homo sapiens_hsa012001.51602788
36Staphylococcus aureus infection_Homo sapiens_hsa051501.49694967
37Biosynthesis of amino acids_Homo sapiens_hsa012301.49287441
38Phenylalanine metabolism_Homo sapiens_hsa003601.48658766
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45828210
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44725311
41Sulfur metabolism_Homo sapiens_hsa009201.42055121
42Bile secretion_Homo sapiens_hsa049761.40032742
43Caffeine metabolism_Homo sapiens_hsa002321.36615754
44Sulfur relay system_Homo sapiens_hsa041221.34659100
45ABC transporters_Homo sapiens_hsa020101.34455079
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34182485
47Retinol metabolism_Homo sapiens_hsa008301.33757574
48Folate biosynthesis_Homo sapiens_hsa007901.33050648
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.29559300
50Tyrosine metabolism_Homo sapiens_hsa003501.28494658
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28439990
52Starch and sucrose metabolism_Homo sapiens_hsa005001.19396248
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12537553
54Fat digestion and absorption_Homo sapiens_hsa049751.12434140
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12002608
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.06195183
57Fatty acid elongation_Homo sapiens_hsa000621.04232738
58Fructose and mannose metabolism_Homo sapiens_hsa000511.03383310
59One carbon pool by folate_Homo sapiens_hsa006701.01920260
60RNA polymerase_Homo sapiens_hsa030200.98701914
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98601479
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90040443
63Sphingolipid metabolism_Homo sapiens_hsa006000.89887444
64Pentose phosphate pathway_Homo sapiens_hsa000300.88202781
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87428506
66Mineral absorption_Homo sapiens_hsa049780.87212888
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84467291
68Arginine and proline metabolism_Homo sapiens_hsa003300.84352800
69Galactose metabolism_Homo sapiens_hsa000520.82784025
70Glutathione metabolism_Homo sapiens_hsa004800.80898143
71Homologous recombination_Homo sapiens_hsa034400.79836981
72Steroid biosynthesis_Homo sapiens_hsa001000.74015292
73N-Glycan biosynthesis_Homo sapiens_hsa005100.73948096
74Vitamin digestion and absorption_Homo sapiens_hsa049770.72353721
75Glycerolipid metabolism_Homo sapiens_hsa005610.68311011
76Ether lipid metabolism_Homo sapiens_hsa005650.67704633
77Basal transcription factors_Homo sapiens_hsa030220.67522765
78Huntingtons disease_Homo sapiens_hsa050160.66194354
79Insulin secretion_Homo sapiens_hsa049110.66193871
80* Metabolic pathways_Homo sapiens_hsa011000.62523721
81Vibrio cholerae infection_Homo sapiens_hsa051100.61419717
82Lysine degradation_Homo sapiens_hsa003100.61094358
83Non-homologous end-joining_Homo sapiens_hsa034500.60222820
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57813203
85Purine metabolism_Homo sapiens_hsa002300.56790529
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56289989
87Fanconi anemia pathway_Homo sapiens_hsa034600.53754766
88Circadian rhythm_Homo sapiens_hsa047100.51459195
89Phototransduction_Homo sapiens_hsa047440.47155619
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38960117
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37452766
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36114936
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35575361
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35146472
95* Vitamin B6 metabolism_Homo sapiens_hsa007500.32722830
96Linoleic acid metabolism_Homo sapiens_hsa005910.30220146
97Systemic lupus erythematosus_Homo sapiens_hsa053220.30038026
98Collecting duct acid secretion_Homo sapiens_hsa049660.27835146
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25915638
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.23331200
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.22117829
102Prion diseases_Homo sapiens_hsa050200.20713378
103Arachidonic acid metabolism_Homo sapiens_hsa005900.19002647
104Oxidative phosphorylation_Homo sapiens_hsa001900.17330448
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15561269
106Insulin resistance_Homo sapiens_hsa049310.14809788
107Regulation of autophagy_Homo sapiens_hsa041400.12701601
108Parkinsons disease_Homo sapiens_hsa050120.09845372
109Fatty acid biosynthesis_Homo sapiens_hsa000610.09677249
110AMPK signaling pathway_Homo sapiens_hsa041520.06834695
111Glucagon signaling pathway_Homo sapiens_hsa049220.05579947
112Renin-angiotensin system_Homo sapiens_hsa04614-0.1498666
113Insulin signaling pathway_Homo sapiens_hsa04910-0.1406322
114Thyroid cancer_Homo sapiens_hsa05216-0.1380097
115Alzheimers disease_Homo sapiens_hsa05010-0.1186908
116Pyrimidine metabolism_Homo sapiens_hsa00240-0.1084813
117Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0942363
118Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0779455
119Bladder cancer_Homo sapiens_hsa05219-0.0551401
120Other glycan degradation_Homo sapiens_hsa00511-0.0508828
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0499271
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0221851

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