PNPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.60776447
2nuclear pore complex assembly (GO:0051292)4.74944499
3folic acid-containing compound biosynthetic process (GO:0009396)4.71318330
4DNA unwinding involved in DNA replication (GO:0006268)4.63197782
5IMP biosynthetic process (GO:0006188)4.53073160
6DNA replication initiation (GO:0006270)4.51181127
7proteasome assembly (GO:0043248)4.45830508
8DNA strand elongation involved in DNA replication (GO:0006271)4.28132026
9IMP metabolic process (GO:0046040)4.23859924
10nucleobase biosynthetic process (GO:0046112)4.19569520
11mitotic nuclear envelope disassembly (GO:0007077)4.13680305
12DNA strand elongation (GO:0022616)4.07941771
13telomere maintenance via semi-conservative replication (GO:0032201)4.06273854
14purine nucleobase biosynthetic process (GO:0009113)4.04785816
15chromatin remodeling at centromere (GO:0031055)3.95675352
16CENP-A containing nucleosome assembly (GO:0034080)3.93503183
17telomere maintenance via recombination (GO:0000722)3.87413295
18kinetochore organization (GO:0051383)3.87124971
19replication fork processing (GO:0031297)3.86504706
20protein localization to kinetochore (GO:0034501)3.85312219
21ribosomal small subunit assembly (GO:0000028)3.81670147
22nuclear envelope disassembly (GO:0051081)3.81403233
23membrane disassembly (GO:0030397)3.81403233
24ribosome assembly (GO:0042255)3.80080767
25mitotic recombination (GO:0006312)3.79519008
26attachment of spindle microtubules to kinetochore (GO:0008608)3.74082507
27mitotic metaphase plate congression (GO:0007080)3.69273725
28DNA geometric change (GO:0032392)3.69188510
29DNA duplex unwinding (GO:0032508)3.68185266
30DNA replication-dependent nucleosome assembly (GO:0006335)3.67951568
31DNA replication-dependent nucleosome organization (GO:0034723)3.67951568
32DNA replication checkpoint (GO:0000076)3.63409973
33regulation of helicase activity (GO:0051095)3.61098141
34pore complex assembly (GO:0046931)3.58737111
35regulation of nuclear cell cycle DNA replication (GO:0033262)3.57163850
36regulation of mitotic spindle checkpoint (GO:1903504)3.53548210
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.53548210
38DNA replication-independent nucleosome organization (GO:0034724)3.41799090
39DNA replication-independent nucleosome assembly (GO:0006336)3.41799090
40formation of translation preinitiation complex (GO:0001731)3.41544362
41metaphase plate congression (GO:0051310)3.39647332
42mitotic chromosome condensation (GO:0007076)3.38203092
43ribosome biogenesis (GO:0042254)3.37220129
44DNA double-strand break processing (GO:0000729)3.34325182
45respiratory chain complex IV assembly (GO:0008535)3.34289810
46telomere maintenance via telomere lengthening (GO:0010833)3.31314410
47tetrahydrofolate metabolic process (GO:0046653)3.29189267
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28829361
49ubiquinone biosynthetic process (GO:0006744)3.26368864
50mitotic sister chromatid cohesion (GO:0007064)3.24707427
51maturation of SSU-rRNA (GO:0030490)3.22003160
52recombinational repair (GO:0000725)3.21939383
53histone exchange (GO:0043486)3.20693236
54double-strand break repair via homologous recombination (GO:0000724)3.19093910
55regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18852492
56regulation of centrosome cycle (GO:0046605)3.18583351
57nucleotide-excision repair, DNA gap filling (GO:0006297)3.16630506
58protein K6-linked ubiquitination (GO:0085020)3.14654435
59DNA topological change (GO:0006265)3.14371120
60ubiquinone metabolic process (GO:0006743)3.11681373
61synapsis (GO:0007129)3.11632717
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10712790
63establishment of chromosome localization (GO:0051303)3.08616037
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07872695
65positive regulation of chromosome segregation (GO:0051984)3.06702262
66* mitochondrial RNA metabolic process (GO:0000959)3.06447157
67positive regulation of mitotic sister chromatid separation (GO:1901970)3.06135162
68positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06135162
69positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06135162
70telomere maintenance (GO:0000723)3.05291341
71protein localization to chromosome, centromeric region (GO:0071459)3.05114825
72regulation of DNA endoreduplication (GO:0032875)3.04829412
73regulation of translational fidelity (GO:0006450)3.04536545
74DNA catabolic process, exonucleolytic (GO:0000738)3.02887948
75telomere organization (GO:0032200)3.02399786
76histone-serine phosphorylation (GO:0035404)3.02252379
77* RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02178792
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00834259
79negative regulation of DNA-dependent DNA replication (GO:2000104)3.00036707
80kynurenine metabolic process (GO:0070189)2.98866405
81ribonucleoprotein complex biogenesis (GO:0022613)2.98148691
82kinetochore assembly (GO:0051382)2.96844371
83sister chromatid segregation (GO:0000819)2.96742762
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95995234
85DNA conformation change (GO:0071103)2.95839898
86meiotic chromosome segregation (GO:0045132)2.94345943
87negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92949873
88rRNA catabolic process (GO:0016075)2.92108047
89DNA strand renaturation (GO:0000733)2.91895582
90translesion synthesis (GO:0019985)2.91840941
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91749705
92regulation of spindle organization (GO:0090224)2.91093612
93maturation of 5.8S rRNA (GO:0000460)2.90544793
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.90263642
95somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.90263642
96isotype switching (GO:0045190)2.90263642
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89754873
98regulation of histone H3-K9 methylation (GO:0051570)2.88843838
99water-soluble vitamin biosynthetic process (GO:0042364)2.88191488
100chromatin assembly or disassembly (GO:0006333)2.87301402
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87198140
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86861346
103somatic hypermutation of immunoglobulin genes (GO:0016446)2.86195078
104somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86195078
105dosage compensation (GO:0007549)2.86029607
106pteridine-containing compound biosynthetic process (GO:0042559)2.86024149
107behavioral response to nicotine (GO:0035095)2.85651735
108mitotic sister chromatid segregation (GO:0000070)2.85053139
109regulation of sister chromatid cohesion (GO:0007063)2.84960919
110resolution of meiotic recombination intermediates (GO:0000712)2.84550090
111establishment of protein localization to mitochondrial membrane (GO:0090151)2.84547072
112regulation of translational termination (GO:0006449)2.83594155
113ribosomal large subunit biogenesis (GO:0042273)2.82001162
114peptidyl-histidine modification (GO:0018202)2.80982952
115reciprocal DNA recombination (GO:0035825)2.80769076
116reciprocal meiotic recombination (GO:0007131)2.80769076
117nuclear envelope organization (GO:0006998)2.80607502
118telomere maintenance via telomerase (GO:0007004)2.80005555
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79899786
120L-fucose metabolic process (GO:0042354)2.79624978
121L-fucose catabolic process (GO:0042355)2.79624978
122fucose catabolic process (GO:0019317)2.79624978
123somatic diversification of immunoglobulins (GO:0016445)2.79343795
124folic acid metabolic process (GO:0046655)2.78921527
125tRNA metabolic process (GO:0006399)2.76609137
126cullin deneddylation (GO:0010388)2.76560292
127termination of RNA polymerase III transcription (GO:0006386)2.75886272
128transcription elongation from RNA polymerase III promoter (GO:0006385)2.75886272
129postreplication repair (GO:0006301)2.75558654
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75285113
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.75285113
132NADH dehydrogenase complex assembly (GO:0010257)2.75285113
133somatic recombination of immunoglobulin gene segments (GO:0016447)2.74790648
134chaperone-mediated protein complex assembly (GO:0051131)2.73804275
135RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73437003
136tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73437003
137pseudouridine synthesis (GO:0001522)2.72196207
138RNA-dependent DNA replication (GO:0006278)2.72131730
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71991040
140cellular ketone body metabolic process (GO:0046950)2.71963758
141DNA deamination (GO:0045006)2.71130600
142spliceosomal snRNP assembly (GO:0000387)2.71036740
143tRNA processing (GO:0008033)2.70672981
144negative regulation of histone methylation (GO:0031061)2.70254473
145regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69942742
146negative regulation of RNA splicing (GO:0033119)2.69181943
147rRNA processing (GO:0006364)2.66386104
148establishment of integrated proviral latency (GO:0075713)2.62471748
149regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62127962
150folic acid-containing compound metabolic process (GO:0006760)2.61589405
151mitotic DNA integrity checkpoint (GO:0044774)2.60251804
152ATP-dependent chromatin remodeling (GO:0043044)2.60242288
153regulation of centriole replication (GO:0046599)2.60127085
154regulation of mitotic spindle organization (GO:0060236)2.59995958
155mitotic G2/M transition checkpoint (GO:0044818)2.59206671
156spindle assembly checkpoint (GO:0071173)2.58356466
157regulation of centrosome duplication (GO:0010824)2.58345945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.73927160
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.07375290
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.87044449
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.63975944
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39687412
6ZNF274_21170338_ChIP-Seq_K562_Hela3.18192617
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85314867
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83280961
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67261833
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.59347419
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58185532
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54320555
13AR_21909140_ChIP-Seq_LNCAP_Human2.44976716
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.40003950
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38235104
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35897184
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32115797
18VDR_22108803_ChIP-Seq_LS180_Human2.30326877
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.27804535
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23785266
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.19677981
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.19447858
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19054844
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11790031
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.02561526
26* ETS1_20019798_ChIP-Seq_JURKAT_Human2.00220319
27EWS_26573619_Chip-Seq_HEK293_Human1.99529715
28VDR_23849224_ChIP-Seq_CD4+_Human1.96668288
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91702038
30XRN2_22483619_ChIP-Seq_HELA_Human1.91560530
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91487620
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89279114
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88551069
34ELK1_19687146_ChIP-ChIP_HELA_Human1.87713748
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82681823
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81187634
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79873315
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78498337
39FUS_26573619_Chip-Seq_HEK293_Human1.76037586
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75627288
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73983674
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.67914086
43DCP1A_22483619_ChIP-Seq_HELA_Human1.67017343
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.65019080
45MYC_22102868_ChIP-Seq_BL_Human1.63424853
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60593576
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59750980
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58890668
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58081371
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57987986
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57664364
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55989446
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54983742
54* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54269449
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48395850
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47436875
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46672412
58IGF1R_20145208_ChIP-Seq_DFB_Human1.42766808
59GABP_19822575_ChIP-Seq_HepG2_Human1.42098571
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.41328658
61* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40010625
62* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39282909
63TTF2_22483619_ChIP-Seq_HELA_Human1.36500886
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33704459
65KDM5A_27292631_Chip-Seq_BREAST_Human1.32090967
66TAF15_26573619_Chip-Seq_HEK293_Human1.31337298
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31218445
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30902310
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30713739
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29707297
71TFEB_21752829_ChIP-Seq_HELA_Human1.29151830
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26774531
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26699170
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24597032
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23422586
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23226379
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22116211
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20947642
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20370317
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20269168
81IRF1_19129219_ChIP-ChIP_H3396_Human1.18881242
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17887251
83ER_23166858_ChIP-Seq_MCF-7_Human1.13004429
84P300_19829295_ChIP-Seq_ESCs_Human1.11863781
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11387421
86* SRF_21415370_ChIP-Seq_HL-1_Mouse1.09967776
87CIITA_25753668_ChIP-Seq_RAJI_Human1.09523754
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08721153
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07365823
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07201464
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05012753
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04671490
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04632610
94TP53_22573176_ChIP-Seq_HFKS_Human1.04104935
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03239552
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03001801
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01693797
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01488887
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00618912
100KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99670067
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.99163479
102SPI1_23547873_ChIP-Seq_NB4_Human0.97660427
103MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97615626
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96552167
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96252410
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.95994950
107* NANOG_19829295_ChIP-Seq_ESCs_Human0.95893616
108* SOX2_19829295_ChIP-Seq_ESCs_Human0.95893616
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95676654
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95499773
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94804065
112EZH2_27294783_Chip-Seq_NPCs_Mouse0.94232330
113* FOXA1_25329375_ChIP-Seq_VCAP_Human0.93864597
114* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93864597
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92984646
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92095710
117YY1_21170310_ChIP-Seq_MESCs_Mouse0.91350214
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91269623
119IRF8_21731497_ChIP-ChIP_J774_Mouse0.90981267
120EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90569708
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89268840
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87304119
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86670251
124GBX2_23144817_ChIP-Seq_PC3_Human0.85946382
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85844511
126MYB_26560356_Chip-Seq_TH1_Human0.85515291
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.84743753
128MYC_18940864_ChIP-ChIP_HL60_Human0.83474992
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81193248
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80710529
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.80638164
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79976253
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79550194
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79350965
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79150766
136CRX_20693478_ChIP-Seq_RETINA_Mouse0.79082846
137MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78680076
138* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78512535
139IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78510902
140* HOXB7_26014856_ChIP-Seq_BT474_Human0.77775708
141CLOCK_20551151_ChIP-Seq_293T_Human0.77093167
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76977541
143CBP_20019798_ChIP-Seq_JUKART_Human0.75322502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.95890098
2MP0010094_abnormal_chromosome_stability3.95061793
3MP0004957_abnormal_blastocyst_morpholog3.66745799
4MP0003806_abnormal_nucleotide_metabolis3.58178586
5MP0003111_abnormal_nucleus_morphology3.31019133
6MP0003077_abnormal_cell_cycle3.23019063
7MP0008057_abnormal_DNA_replication3.15177456
8MP0010352_gastrointestinal_tract_polyps2.99258883
9MP0010307_abnormal_tumor_latency2.84711579
10MP0008007_abnormal_cellular_replicative2.61512406
11MP0003195_calcinosis2.61183604
12MP0003136_yellow_coat_color2.50637947
13MP0003123_paternal_imprinting2.44421989
14MP0002396_abnormal_hematopoietic_system2.40492048
15MP0008058_abnormal_DNA_repair2.33963482
16MP0002102_abnormal_ear_morphology2.12029042
17MP0008932_abnormal_embryonic_tissue2.05082516
18MP0009697_abnormal_copulation2.03165666
19MP0001730_embryonic_growth_arrest2.02938112
20MP0003646_muscle_fatigue1.84631951
21MP0000350_abnormal_cell_proliferation1.83970063
22MP0003705_abnormal_hypodermis_morpholog1.83526201
23MP0004808_abnormal_hematopoietic_stem1.77501693
24MP0006292_abnormal_olfactory_placode1.69692559
25MP0001986_abnormal_taste_sensitivity1.68855158
26MP0003941_abnormal_skin_development1.66040537
27MP0000490_abnormal_crypts_of1.65285097
28MP0006054_spinal_hemorrhage1.63825900
29MP0003567_abnormal_fetal_cardiomyocyte1.63366226
30MP0002938_white_spotting1.61089961
31MP0006072_abnormal_retinal_apoptosis1.60938724
32MP0000569_abnormal_digit_pigmentation1.59164466
33MP0008872_abnormal_physiological_respon1.54687719
34MP0003186_abnormal_redox_activity1.54533406
35MP0001672_abnormal_embryogenesis/_devel1.54067599
36MP0005380_embryogenesis_phenotype1.54067599
37MP0004197_abnormal_fetal_growth/weight/1.53355491
38MP0010234_abnormal_vibrissa_follicle1.50681575
39MP0002086_abnormal_extraembryonic_tissu1.48924146
40MP0003984_embryonic_growth_retardation1.48241733
41MP0003950_abnormal_plasma_membrane1.48201064
42MP0001697_abnormal_embryo_size1.47798487
43MP0009046_muscle_twitch1.47752362
44MP0002088_abnormal_embryonic_growth/wei1.45501228
45MP0006035_abnormal_mitochondrial_morpho1.45142451
46MP0005084_abnormal_gallbladder_morpholo1.42339090
47MP0001545_abnormal_hematopoietic_system1.40759427
48MP0005397_hematopoietic_system_phenotyp1.40759427
49MP0002080_prenatal_lethality1.39839998
50MP0008875_abnormal_xenobiotic_pharmacok1.38845426
51MP0000647_abnormal_sebaceous_gland1.38688288
52MP0005551_abnormal_eye_electrophysiolog1.36917614
53MP0000427_abnormal_hair_cycle1.33797626
54MP0002019_abnormal_tumor_incidence1.33449903
55MP0002139_abnormal_hepatobiliary_system1.32804990
56MP0003937_abnormal_limbs/digits/tail_de1.31771530
57MP0002006_tumorigenesis1.29426277
58MP0004043_abnormal_pH_regulation1.28396390
59MP0002736_abnormal_nociception_after1.27738618
60MP0005076_abnormal_cell_differentiation1.25595323
61MP0002084_abnormal_developmental_patter1.24054896
62MP0004147_increased_porphyrin_level1.22026344
63MP0002166_altered_tumor_susceptibility1.21900022
64MP0002160_abnormal_reproductive_system1.21509424
65MP0001929_abnormal_gametogenesis1.21404525
66MP0001919_abnormal_reproductive_system1.21319680
67MP0000372_irregular_coat_pigmentation1.20528805
68MP0000313_abnormal_cell_death1.20310448
69MP0005389_reproductive_system_phenotype1.20152262
70MP0003656_abnormal_erythrocyte_physiolo1.18686584
71MP0005253_abnormal_eye_physiology1.18637131
72MP0002210_abnormal_sex_determination1.18098855
73MP0003763_abnormal_thymus_physiology1.17648387
74MP0003890_abnormal_embryonic-extraembry1.17378496
75MP0005360_urolithiasis1.14213833
76MP0002398_abnormal_bone_marrow1.14204290
77MP0002234_abnormal_pharynx_morphology1.13944675
78MP0001915_intracranial_hemorrhage1.13463269
79MP0003566_abnormal_cell_adhesion1.12498727
80MP0004142_abnormal_muscle_tone1.12048355
81MP0002085_abnormal_embryonic_tissue1.11427278
82MP0000383_abnormal_hair_follicle1.11412165
83MP0003786_premature_aging1.10769167
84MP0004215_abnormal_myocardial_fiber1.09622901
85MP0000689_abnormal_spleen_morphology1.09433321
86MP0003119_abnormal_digestive_system1.09393944
87MP0002837_dystrophic_cardiac_calcinosis1.08502117
88MP0002722_abnormal_immune_system1.07388472
89MP0003121_genomic_imprinting1.07357484
90MP0008995_early_reproductive_senescence1.03316036
91MP0002638_abnormal_pupillary_reflex1.02515042
92MP0001293_anophthalmia1.01262767
93MP0009333_abnormal_splenocyte_physiolog0.99862783
94MP0000703_abnormal_thymus_morphology0.99813817
95MP0000598_abnormal_liver_morphology0.97218493
96MP0001485_abnormal_pinna_reflex0.96652880
97MP0005023_abnormal_wound_healing0.96175174
98MP0001835_abnormal_antigen_presentation0.95747793
99MP0008877_abnormal_DNA_methylation0.94980793
100MP0000653_abnormal_sex_gland0.93956511
101MP0001853_heart_inflammation0.92797262
102MP0003943_abnormal_hepatobiliary_system0.91793639
103MP0002429_abnormal_blood_cell0.90738522
104MP0001145_abnormal_male_reproductive0.90418870
105MP0005410_abnormal_fertilization0.90387217
106MP0009053_abnormal_anal_canal0.90326760
107MP0002163_abnormal_gland_morphology0.90065619
108MP0003221_abnormal_cardiomyocyte_apopto0.89416999
109MP0001800_abnormal_humoral_immune0.88720134
110MP0001119_abnormal_female_reproductive0.88487359
111MP0001968_abnormal_touch/_nociception0.87985191
112MP0009785_altered_susceptibility_to0.87861664
113MP0006036_abnormal_mitochondrial_physio0.86363438
114MP0004264_abnormal_extraembryonic_tissu0.86056193
115MP0005085_abnormal_gallbladder_physiolo0.85925921
116MP0009672_abnormal_birth_weight0.84898443
117MP0000858_altered_metastatic_potential0.84701764
118MP0001286_abnormal_eye_development0.83983767
119MP0004145_abnormal_muscle_electrophysio0.83754205
120MP0001324_abnormal_eye_pigmentation0.83290470
121MP0005266_abnormal_metabolism0.81827978
122MP0005395_other_phenotype0.81331938
123MP0005391_vision/eye_phenotype0.79874349
124MP0005187_abnormal_penis_morphology0.79802974
125MP0003448_altered_tumor_morphology0.79023431
126MP0001529_abnormal_vocalization0.78393450
127MP0004133_heterotaxia0.77679630
128MP0003315_abnormal_perineum_morphology0.77540402
129MP0002095_abnormal_skin_pigmentation0.77058219
130MP0000716_abnormal_immune_system0.75924365
131MP0005464_abnormal_platelet_physiology0.75683920
132MP0005408_hypopigmentation0.75206087
133MP0002452_abnormal_antigen_presenting0.74816355
134MP0003300_gastrointestinal_ulcer0.74697816
135MP0003698_abnormal_male_reproductive0.74343464
136MP0000358_abnormal_cell_content/0.74042411
137MP0001764_abnormal_homeostasis0.73370391
138MP0009763_increased_sensitivity_to0.73325798
139MP0005384_cellular_phenotype0.73029262
140MP0002254_reproductive_system_inflammat0.72699702
141MP0002282_abnormal_trachea_morphology0.72497562
142MP0005319_abnormal_enzyme/_coenzyme0.71448435
143MP0009703_decreased_birth_body0.71150576
144MP0005621_abnormal_cell_physiology0.70849928
145MP0000685_abnormal_immune_system0.69388876
146MP0010155_abnormal_intestine_physiology0.68518405
147MP0000609_abnormal_liver_physiology0.67406793
148MP0008438_abnormal_cutaneous_collagen0.66792340
149MP0003718_maternal_effect0.66344915
150MP0005332_abnormal_amino_acid0.66296656
151MP0000631_abnormal_neuroendocrine_gland0.65307180
152MP0005195_abnormal_posterior_eye0.64644521
153MP0002723_abnormal_immune_serum0.64538335
154MP0000537_abnormal_urethra_morphology0.64488406
155MP0002420_abnormal_adaptive_immunity0.63736302
156MP0002751_abnormal_autonomic_nervous0.63668082
157MP0000477_abnormal_intestine_morphology0.63172350
158MP0002092_abnormal_eye_morphology0.63158505
159MP0003436_decreased_susceptibility_to0.62916381
160MP0008469_abnormal_protein_level0.62692464
161MP0005379_endocrine/exocrine_gland_phen0.62665925
162MP0001819_abnormal_immune_cell0.60724252

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)4.21501380
2Hyperalaninemia (HP:0003348)4.21501380
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.21501380
4Birth length less than 3rd percentile (HP:0003561)4.03364930
5Selective tooth agenesis (HP:0001592)3.80146459
6Colon cancer (HP:0003003)3.45229133
7Pancreatic cysts (HP:0001737)3.41854333
8Abnormality of midbrain morphology (HP:0002418)3.29331053
9Molar tooth sign on MRI (HP:0002419)3.29331053
10Progressive inability to walk (HP:0002505)3.22923761
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.22152787
12Ependymoma (HP:0002888)3.12851746
13Abnormality of the ileum (HP:0001549)3.11263375
14Rhabdomyosarcoma (HP:0002859)3.08971976
15Agnosia (HP:0010524)3.06738235
16Medulloblastoma (HP:0002885)3.05262409
17Abnormality of chromosome stability (HP:0003220)3.04933043
18Pancreatic fibrosis (HP:0100732)2.89267205
19True hermaphroditism (HP:0010459)2.84974213
20Chromsome breakage (HP:0040012)2.84394112
21Thrombocytosis (HP:0001894)2.83444570
22Abnormality of the anterior horn cell (HP:0006802)2.71299409
23Degeneration of anterior horn cells (HP:0002398)2.71299409
24Oral leukoplakia (HP:0002745)2.70753043
2511 pairs of ribs (HP:0000878)2.68028552
26Nephronophthisis (HP:0000090)2.65477553
27Amaurosis fugax (HP:0100576)2.65223103
28Increased CSF lactate (HP:0002490)2.62591214
29Aplastic anemia (HP:0001915)2.62378667
30Abnormality of the pons (HP:0007361)2.59804238
31Large for gestational age (HP:0001520)2.58969185
32Reticulocytopenia (HP:0001896)2.57633871
33Abnormal number of incisors (HP:0011064)2.56925925
34Increased serum lactate (HP:0002151)2.53699321
35Abnormality of the renal cortex (HP:0011035)2.53437444
36Abnormality of the heme biosynthetic pathway (HP:0010472)2.51909456
37Deviation of the thumb (HP:0009603)2.50929655
38Proximal placement of thumb (HP:0009623)2.49091151
39Cutaneous melanoma (HP:0012056)2.48069117
40Abnormality of pyrimidine metabolism (HP:0004353)2.46754425
41Volvulus (HP:0002580)2.44940382
42Basal cell carcinoma (HP:0002671)2.40879009
43Spastic diplegia (HP:0001264)2.37940827
44Squamous cell carcinoma (HP:0002860)2.34506532
45Inability to walk (HP:0002540)2.34156063
46Acute encephalopathy (HP:0006846)2.33397345
47Increased hepatocellular lipid droplets (HP:0006565)2.32825896
48Abnormality of serum amino acid levels (HP:0003112)2.31973173
49Congenital, generalized hypertrichosis (HP:0004540)2.31143307
50Myelodysplasia (HP:0002863)2.30395046
51Glioma (HP:0009733)2.28937294
52Lipid accumulation in hepatocytes (HP:0006561)2.28761753
53Astrocytoma (HP:0009592)2.26674751
54Abnormality of the astrocytes (HP:0100707)2.26674751
55Acute myeloid leukemia (HP:0004808)2.25831269
56Increased serum pyruvate (HP:0003542)2.20041795
57Duplicated collecting system (HP:0000081)2.19917208
58Abnormality of T cell number (HP:0011839)2.19481874
59Abnormality of the renal medulla (HP:0100957)2.19453802
60Chronic hepatic failure (HP:0100626)2.19026810
61Lymphoma (HP:0002665)2.18700537
62Acute necrotizing encephalopathy (HP:0006965)2.18194074
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18054550
64Hypoplasia of the pons (HP:0012110)2.17956890
65Medial flaring of the eyebrow (HP:0010747)2.17671251
66Pallor (HP:0000980)2.17493770
67T lymphocytopenia (HP:0005403)2.16574907
68Abnormality of the carotid arteries (HP:0005344)2.16345664
69Clubbing of toes (HP:0100760)2.14495110
70Cellular immunodeficiency (HP:0005374)2.10940566
71Nausea (HP:0002018)2.10562397
72Neoplasm of striated muscle (HP:0009728)2.10482834
73Abnormality of cells of the erythroid lineage (HP:0012130)2.10315283
74Hypobetalipoproteinemia (HP:0003563)2.09204831
75Mitochondrial inheritance (HP:0001427)2.09057177
76Tubular atrophy (HP:0000092)2.09012675
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.08405621
78Missing ribs (HP:0000921)2.04823202
79Abnormality of the duodenum (HP:0002246)2.04632933
80Furrowed tongue (HP:0000221)2.04475307
81Congenital stationary night blindness (HP:0007642)2.02348515
82Biliary tract neoplasm (HP:0100574)2.02204612
83Hepatocellular necrosis (HP:0001404)2.01768608
84Hypochromic microcytic anemia (HP:0004840)2.01521645
85Neoplasm of the adrenal gland (HP:0100631)2.01282743
86Abnormality of the renal collecting system (HP:0004742)2.01103783
87Neoplasm of the pancreas (HP:0002894)2.00174207
88Renal cortical cysts (HP:0000803)1.99898235
89Recurrent viral infections (HP:0004429)1.99744924
90Abnormality of glycolysis (HP:0004366)1.99699272
91Lactic acidosis (HP:0003128)1.98386036
92Aplasia/Hypoplasia of the patella (HP:0006498)1.97827515
93Freckling (HP:0001480)1.97709578
94Impulsivity (HP:0100710)1.95635539
95Sloping forehead (HP:0000340)1.95338612
96High pitched voice (HP:0001620)1.95295437
97Ovarian neoplasm (HP:0100615)1.95160655
98Abnormal number of erythroid precursors (HP:0012131)1.94566343
99Supernumerary spleens (HP:0009799)1.93996026
100Pendular nystagmus (HP:0012043)1.93025057
101Rough bone trabeculation (HP:0100670)1.92687721
102Hepatic necrosis (HP:0002605)1.92570411
103Prominent nose (HP:0000448)1.92427928
104Sclerocornea (HP:0000647)1.91992493
105Abnormal mitochondria in muscle tissue (HP:0008316)1.91976686
106Abnormal platelet volume (HP:0011876)1.91901090
107Cafe-au-lait spot (HP:0000957)1.91083445
108Premature graying of hair (HP:0002216)1.89892167
109Hypochromic anemia (HP:0001931)1.89864761
110Bilateral microphthalmos (HP:0007633)1.87944623
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87887589
112Abnormal protein N-linked glycosylation (HP:0012347)1.87887589
113Abnormal protein glycosylation (HP:0012346)1.87887589
114Abnormal glycosylation (HP:0012345)1.87887589
115Methylmalonic acidemia (HP:0002912)1.87389636
116Abnormal lung lobation (HP:0002101)1.86817010
117Hyperglycinuria (HP:0003108)1.86066863
118Ascites (HP:0001541)1.85146115
119Intestinal polyposis (HP:0200008)1.84888432
120IgM deficiency (HP:0002850)1.83945731
121Increased mean platelet volume (HP:0011877)1.83580775
122Angiofibromas (HP:0010615)1.83478877
123Adenoma sebaceum (HP:0009720)1.83478877
124Acanthocytosis (HP:0001927)1.83372530
125Triphalangeal thumb (HP:0001199)1.82500827
126Intrahepatic cholestasis (HP:0001406)1.81751993
127Autoimmune thrombocytopenia (HP:0001973)1.81590353
128Neoplasm of the colon (HP:0100273)1.80879701
129Abnormality of methionine metabolism (HP:0010901)1.80681548
130Microretrognathia (HP:0000308)1.80360585
131Congenital primary aphakia (HP:0007707)1.79986397
132Upper motor neuron abnormality (HP:0002127)1.79756758
133Increased nuchal translucency (HP:0010880)1.79683068
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.79540054
135Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78860360
136Intestinal polyp (HP:0005266)1.78726525
137Abnormal biliary tract morphology (HP:0012440)1.78571554
138Limb hypertonia (HP:0002509)1.78539483
139Breast hypoplasia (HP:0003187)1.78141607
140Progressive macrocephaly (HP:0004481)1.77734190
141Abnormality of reticulocytes (HP:0004312)1.77209070
142Attenuation of retinal blood vessels (HP:0007843)1.75833598
143Bone marrow hypocellularity (HP:0005528)1.75364486
144Meckel diverticulum (HP:0002245)1.75078661
145Abnormality of T cell physiology (HP:0011840)1.74891408
146Cerebellar dysplasia (HP:0007033)1.74403654
147Abnormality of T cells (HP:0002843)1.73468400
148Cervical subluxation (HP:0003308)1.72334268
149Abolished electroretinogram (ERG) (HP:0000550)1.71673873
150Neoplasm of the oral cavity (HP:0100649)1.71230048
151Type I transferrin isoform profile (HP:0003642)1.71042733
152Gait imbalance (HP:0002141)1.70164666
153Hematochezia (HP:0002573)1.69993318
154Aplasia/hypoplasia of the humerus (HP:0006507)1.69839818
155Lethargy (HP:0001254)1.69656506
156Skull defect (HP:0001362)1.69100768
157Type II lissencephaly (HP:0007260)1.68512374
158Methylmalonic aciduria (HP:0012120)1.68450739
159Pancytopenia (HP:0001876)1.67643517
160Asplenia (HP:0001746)1.67633203
161Abnormality of the preputium (HP:0100587)1.66873974
162Cystic liver disease (HP:0006706)1.66374930
163Patellar aplasia (HP:0006443)1.66366264
164Abnormality of the calcaneus (HP:0008364)1.66363804
165Pancreatic islet-cell hyperplasia (HP:0004510)1.66199128
166Blepharitis (HP:0000498)1.66155054
167Cerebral edema (HP:0002181)1.65709601
168Microvesicular hepatic steatosis (HP:0001414)1.65553035
169Hyperglycinemia (HP:0002154)1.65223858
170Meningioma (HP:0002858)1.64766600
171Small hand (HP:0200055)1.64650700
172Neoplasm of the rectum (HP:0100743)1.64636962
173Duodenal stenosis (HP:0100867)1.64585847
174Small intestinal stenosis (HP:0012848)1.64585847
175Nephrogenic diabetes insipidus (HP:0009806)1.64462208
176Abnormality of the labia minora (HP:0012880)1.63840338
177Dandy-Walker malformation (HP:0001305)1.63331979
178Astigmatism (HP:0000483)1.62821586
179Short tibia (HP:0005736)1.61814666
180Absent thumb (HP:0009777)1.60728465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.99204849
2CDC74.10873712
3WEE13.76167197
4BMPR1B3.01366842
5NEK12.65238854
6BUB12.44828353
7EIF2AK32.44635289
8NEK22.37024478
9SCYL22.27430348
10SRPK12.14633004
11NUAK12.14062239
12PDK22.13418157
13PKN22.13094902
14ACVR1B2.10564379
15WNK42.09183392
16TTK2.07630374
17FLT31.98765559
18ADRBK21.97278203
19PLK41.92692232
20BRSK21.92342753
21RPS6KB21.91916711
22MKNK11.91274964
23STK101.80472480
24STK391.73125166
25CDK121.71889447
26TRIM281.68319443
27ATR1.65697383
28PASK1.61291199
29EEF2K1.60737391
30TSSK61.57947092
31MAP3K81.51348226
32AURKB1.51261531
33NME21.49080976
34PNCK1.48354061
35PLK11.45065822
36VRK21.43954142
37WNK31.42868604
38TGFBR11.42036922
39RPS6KA41.40643863
40GRK11.40451348
41FRK1.39339563
42PLK31.38412790
43VRK11.30894322
44ZAK1.28700324
45CDK41.28691616
46CDK61.23791422
47CDK71.22970255
48TLK11.20427063
49BCKDK1.19846863
50JAK31.19320218
51EIF2AK21.17599246
52OXSR11.12955832
53STK41.12233476
54NEK91.09438931
55STK161.02694301
56CHEK11.02512204
57NME11.00963435
58MAP3K101.00633070
59TAF11.00451922
60TNIK0.99709188
61STK30.96717684
62PAK40.95939424
63ATM0.95618842
64LRRK20.94253776
65PBK0.94139391
66TYK20.93312469
67MAP2K30.92432669
68MAP3K140.90591851
69ALK0.89380380
70MST40.88100654
71MAP4K10.86790069
72PIM10.83830913
73CHEK20.83747808
74MAPKAPK50.83652787
75CDK80.82058993
76EPHA20.82002215
77MKNK20.80196391
78IRAK10.76441296
79KIT0.74239526
80AURKA0.73315709
81ERBB40.72164748
82BRD40.71564150
83TEC0.70637345
84CDK20.70570507
85MAP3K40.70310520
86CSNK2A20.68970675
87CSNK1G10.67611430
88PLK20.66472530
89BRSK10.66270637
90MAP4K20.63017912
91TTN0.60113937
92DYRK30.58330073
93LATS10.57638099
94FGFR30.57117227
95CSNK2A10.56310985
96BCR0.55304413
97TRPM70.55120557
98FGFR10.54640000
99CDK10.53944011
100CCNB10.53088843
101RPS6KA50.52164669
102BTK0.50359281
103PINK10.49417236
104MELK0.47731498
105MAP3K120.47567000
106MUSK0.46126928
107CSNK1G30.45457051
108CDK30.44833528
109MET0.44112539
110KDR0.43797566
111TESK20.42738151
112MARK30.42579969
113FGFR40.42019338
114MAPK130.41603161
115CLK10.41514941
116STK38L0.40742860
117PRKDC0.40180079
118PRKCI0.38709435
119ADRBK10.38684246
120INSRR0.38249341
121PRKCG0.38230380
122CSNK1G20.38172071
123PDGFRA0.37655531
124MAPKAPK30.37457516
125CSNK1E0.37159638
126CSF1R0.36612613
127CSNK1A1L0.35996444
128PRKCE0.32965465
129PAK20.32499458
130MAP2K70.31821872
131MTOR0.30670333
132MAPK110.30392253
133TBK10.30335569
134ERBB30.30046745
135PTK60.29400283
136IRAK40.28483288
137LCK0.28233699
138CHUK0.28172021
139ZAP700.27852641
140RPS6KB10.27686701
141TXK0.27594707
142CSNK1D0.24452760
143YES10.24435915
144LYN0.23778898
145PRKACB0.20833312
146WNK10.19116046
147CSNK1A10.18657440

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49373893
2Mismatch repair_Homo sapiens_hsa034303.92474613
3One carbon pool by folate_Homo sapiens_hsa006703.48373299
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40054827
5RNA transport_Homo sapiens_hsa030132.73405850
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67166732
7Spliceosome_Homo sapiens_hsa030402.65533797
8Homologous recombination_Homo sapiens_hsa034402.53055102
9Base excision repair_Homo sapiens_hsa034102.52944723
10Nucleotide excision repair_Homo sapiens_hsa034202.49587637
11Proteasome_Homo sapiens_hsa030502.41445838
12Cell cycle_Homo sapiens_hsa041102.30387421
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22285569
14Non-homologous end-joining_Homo sapiens_hsa034502.19174450
15Ribosome_Homo sapiens_hsa030102.10715178
16* RNA degradation_Homo sapiens_hsa030181.96286409
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94071807
18* Pyrimidine metabolism_Homo sapiens_hsa002401.91379426
19Oxidative phosphorylation_Homo sapiens_hsa001901.81606492
20RNA polymerase_Homo sapiens_hsa030201.80675458
21Systemic lupus erythematosus_Homo sapiens_hsa053221.79894350
22Selenocompound metabolism_Homo sapiens_hsa004501.62937124
23Fanconi anemia pathway_Homo sapiens_hsa034601.59495032
24Butanoate metabolism_Homo sapiens_hsa006501.58377799
25Parkinsons disease_Homo sapiens_hsa050121.57798454
26p53 signaling pathway_Homo sapiens_hsa041151.37925389
27Biosynthesis of amino acids_Homo sapiens_hsa012301.32852257
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.28327664
29Antigen processing and presentation_Homo sapiens_hsa046121.28107764
30Herpes simplex infection_Homo sapiens_hsa051681.24825841
31Phototransduction_Homo sapiens_hsa047441.23022518
32Caffeine metabolism_Homo sapiens_hsa002321.21744961
33mRNA surveillance pathway_Homo sapiens_hsa030151.21429013
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19005987
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.17837805
36Steroid biosynthesis_Homo sapiens_hsa001001.16310119
37Viral carcinogenesis_Homo sapiens_hsa052031.11081486
38Huntingtons disease_Homo sapiens_hsa050161.09375259
39Basal transcription factors_Homo sapiens_hsa030221.08498311
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08473922
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07698655
42Carbon metabolism_Homo sapiens_hsa012001.06960866
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06134266
44Tryptophan metabolism_Homo sapiens_hsa003801.05451550
45Pentose phosphate pathway_Homo sapiens_hsa000301.01463091
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.00125285
47Fatty acid elongation_Homo sapiens_hsa000621.00108207
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99222628
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98909742
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98561829
51Epstein-Barr virus infection_Homo sapiens_hsa051690.96543075
52Legionellosis_Homo sapiens_hsa051340.95247839
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90836766
54Folate biosynthesis_Homo sapiens_hsa007900.84904125
55Ether lipid metabolism_Homo sapiens_hsa005650.81441882
56Alzheimers disease_Homo sapiens_hsa050100.79194714
57Measles_Homo sapiens_hsa051620.78915064
58* Purine metabolism_Homo sapiens_hsa002300.78889430
59Linoleic acid metabolism_Homo sapiens_hsa005910.78260339
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78019400
61Sulfur metabolism_Homo sapiens_hsa009200.74217920
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73936569
63Small cell lung cancer_Homo sapiens_hsa052220.71556289
64Sulfur relay system_Homo sapiens_hsa041220.70668557
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68799141
66Metabolic pathways_Homo sapiens_hsa011000.68295327
67Propanoate metabolism_Homo sapiens_hsa006400.66984777
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66929118
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65994004
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65553095
71Fatty acid metabolism_Homo sapiens_hsa012120.65409040
72Protein export_Homo sapiens_hsa030600.65057330
73Thyroid cancer_Homo sapiens_hsa052160.63267635
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.62861889
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61706208
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60585947
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59747103
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.59742129
79beta-Alanine metabolism_Homo sapiens_hsa004100.59555844
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.59357340
81Glutathione metabolism_Homo sapiens_hsa004800.59030940
82HTLV-I infection_Homo sapiens_hsa051660.58897835
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58839538
84Lysine degradation_Homo sapiens_hsa003100.57223707
85Influenza A_Homo sapiens_hsa051640.57000266
86Vitamin digestion and absorption_Homo sapiens_hsa049770.55806343
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55528974
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52973104
89Nitrogen metabolism_Homo sapiens_hsa009100.52704328
90Apoptosis_Homo sapiens_hsa042100.51619692
91Fat digestion and absorption_Homo sapiens_hsa049750.51058809
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50219915
93Leishmaniasis_Homo sapiens_hsa051400.49075376
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47514072
95Fatty acid degradation_Homo sapiens_hsa000710.46534716
96MicroRNAs in cancer_Homo sapiens_hsa052060.46474150
97Galactose metabolism_Homo sapiens_hsa000520.46434229
98Pyruvate metabolism_Homo sapiens_hsa006200.46304452
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.45632998
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45543438
101Hepatitis B_Homo sapiens_hsa051610.43875441
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42201097
103Vitamin B6 metabolism_Homo sapiens_hsa007500.40720469
104Renin-angiotensin system_Homo sapiens_hsa046140.38696343
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38089941
106Oocyte meiosis_Homo sapiens_hsa041140.38019361
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.37188699
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.37161478
109Complement and coagulation cascades_Homo sapiens_hsa046100.37122434
110Arginine biosynthesis_Homo sapiens_hsa002200.36849395
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36376687
112Regulation of autophagy_Homo sapiens_hsa041400.36295576
113Alcoholism_Homo sapiens_hsa050340.35629751
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35052844
115Fatty acid biosynthesis_Homo sapiens_hsa000610.34306488
116Olfactory transduction_Homo sapiens_hsa047400.33846553
117Primary immunodeficiency_Homo sapiens_hsa053400.33790473
118Chemical carcinogenesis_Homo sapiens_hsa052040.33780956
119Allograft rejection_Homo sapiens_hsa053300.32900666
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32588540
121Cardiac muscle contraction_Homo sapiens_hsa042600.32189486
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30797914
123TGF-beta signaling pathway_Homo sapiens_hsa043500.30528030
124Staphylococcus aureus infection_Homo sapiens_hsa051500.30076560
125ABC transporters_Homo sapiens_hsa020100.29627625
126Peroxisome_Homo sapiens_hsa041460.28341278
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27496564
128HIF-1 signaling pathway_Homo sapiens_hsa040660.26682490
129Sphingolipid metabolism_Homo sapiens_hsa006000.26537381
130Graft-versus-host disease_Homo sapiens_hsa053320.25668623
131Arginine and proline metabolism_Homo sapiens_hsa003300.25291269
132N-Glycan biosynthesis_Homo sapiens_hsa005100.24664478
133Hepatitis C_Homo sapiens_hsa051600.23708236
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23097369
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.22996364
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22802881
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21907259
138Shigellosis_Homo sapiens_hsa051310.21441985
139Taste transduction_Homo sapiens_hsa047420.20753227
140Hematopoietic cell lineage_Homo sapiens_hsa046400.20202529

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