POC1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutation in this gene result in autosomal-recessive cone-rod dystrophy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.85250538
2DNA strand elongation involved in DNA replication (GO:0006271)4.64945855
3neural tube formation (GO:0001841)4.59646475
4DNA strand elongation (GO:0022616)4.41342536
5protein localization to chromosome, centromeric region (GO:0071459)4.31473107
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.17659001
7telomere maintenance via semi-conservative replication (GO:0032201)4.16636420
8mitotic sister chromatid cohesion (GO:0007064)4.13187356
9protein localization to kinetochore (GO:0034501)4.09500672
10thrombin receptor signaling pathway (GO:0070493)4.03959560
11protein K11-linked deubiquitination (GO:0035871)4.00825722
12indolalkylamine metabolic process (GO:0006586)3.91068861
13protein neddylation (GO:0045116)3.84576318
14indole-containing compound catabolic process (GO:0042436)3.82735022
15indolalkylamine catabolic process (GO:0046218)3.82735022
16tryptophan catabolic process (GO:0006569)3.82735022
17L-fucose catabolic process (GO:0042355)3.76724156
18fucose catabolic process (GO:0019317)3.76724156
19L-fucose metabolic process (GO:0042354)3.76724156
20telomere maintenance via recombination (GO:0000722)3.73091999
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71909087
22mitotic recombination (GO:0006312)3.67773017
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60607217
24ribosomal small subunit assembly (GO:0000028)3.54946296
25cilium or flagellum-dependent cell motility (GO:0001539)3.52710069
26tryptophan metabolic process (GO:0006568)3.51819185
27mitotic metaphase plate congression (GO:0007080)3.50243606
28nucleotide-excision repair, DNA gap filling (GO:0006297)3.49875567
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43707842
30mitotic chromosome condensation (GO:0007076)3.43356336
31regulation of memory T cell differentiation (GO:0043380)3.42236551
32telomere maintenance via telomere lengthening (GO:0010833)3.40368616
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.38623137
34purinergic nucleotide receptor signaling pathway (GO:0035590)3.37422833
35CENP-A containing nucleosome assembly (GO:0034080)3.36853302
36negative regulation of mast cell activation (GO:0033004)3.36366608
37chromatin remodeling at centromere (GO:0031055)3.35205285
38metaphase plate congression (GO:0051310)3.33339155
39DNA replication initiation (GO:0006270)3.32337898
40kinetochore organization (GO:0051383)3.31452954
41DNA replication-independent nucleosome assembly (GO:0006336)3.27906302
42DNA replication-independent nucleosome organization (GO:0034724)3.27906302
43DNA double-strand break processing (GO:0000729)3.26325245
44translesion synthesis (GO:0019985)3.25591779
45sister chromatid segregation (GO:0000819)3.24474867
46attachment of spindle microtubules to kinetochore (GO:0008608)3.23930514
473-UTR-mediated mRNA stabilization (GO:0070935)3.23098598
48adenosine metabolic process (GO:0046085)3.21777828
49establishment of chromosome localization (GO:0051303)3.20841380
50axoneme assembly (GO:0035082)3.14097901
51chromosome condensation (GO:0030261)3.12782368
52interkinetic nuclear migration (GO:0022027)3.12443759
53DNA topological change (GO:0006265)3.12155371
54mitotic nuclear envelope disassembly (GO:0007077)3.10905991
55viral transcription (GO:0019083)3.08589914
56mitotic sister chromatid segregation (GO:0000070)3.07297720
57hepatocyte apoptotic process (GO:0097284)3.04771473
58kynurenine metabolic process (GO:0070189)3.03298088
59replication fork processing (GO:0031297)3.02286794
60positive regulation of granulocyte differentiation (GO:0030854)3.01814888
61histone exchange (GO:0043486)2.98265115
62meiotic chromosome segregation (GO:0045132)2.96518988
63epithelial cilium movement (GO:0003351)2.96074076
64translational termination (GO:0006415)2.95099178
65regulation of MHC class II biosynthetic process (GO:0045346)2.93224878
66cellular biogenic amine catabolic process (GO:0042402)2.93032180
67amine catabolic process (GO:0009310)2.93032180
68DNA packaging (GO:0006323)2.91228793
69regulation of B cell receptor signaling pathway (GO:0050855)2.90852836
70protein K63-linked deubiquitination (GO:0070536)2.90192698
71rRNA catabolic process (GO:0016075)2.89715669
72regulation of chromosome segregation (GO:0051983)2.89469326
73DNA duplex unwinding (GO:0032508)2.88519151
74nuclear pore organization (GO:0006999)2.87501976
75DNA geometric change (GO:0032392)2.87021523
76DNA demethylation (GO:0080111)2.86738309
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86205029
78negative regulation of thymocyte apoptotic process (GO:0070244)2.85508669
79protein localization to chromosome (GO:0034502)2.85313120
80nuclear envelope disassembly (GO:0051081)2.84504760
81membrane disassembly (GO:0030397)2.84504760
82cilium movement (GO:0003341)2.83380189
83mismatch repair (GO:0006298)2.81572719
84detection of light stimulus involved in sensory perception (GO:0050962)2.79100012
85detection of light stimulus involved in visual perception (GO:0050908)2.79100012
86ATP-dependent chromatin remodeling (GO:0043044)2.79071707
87multicellular organism reproduction (GO:0032504)2.78936483
88DNA conformation change (GO:0071103)2.77698630
89establishment of protein localization to Golgi (GO:0072600)2.77506625
90negative regulation of RNA splicing (GO:0033119)2.77424845
91centriole replication (GO:0007099)2.77124535
92G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77076290
93microtubule depolymerization (GO:0007019)2.76392908
94negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76350645
95tyrosine phosphorylation of STAT protein (GO:0007260)2.76113114
96recombinational repair (GO:0000725)2.75499936
97protein targeting to ER (GO:0045047)2.74833898
98double-strand break repair via homologous recombination (GO:0000724)2.74444270
99telomere maintenance (GO:0000723)2.74141109
100cotranslational protein targeting to membrane (GO:0006613)2.74106350
101RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73587388
102regulation of cilium movement (GO:0003352)2.71928074
103negative regulation of T-helper cell differentiation (GO:0045623)2.71540313
104negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71540313
105RNA stabilization (GO:0043489)2.71329237
106mRNA stabilization (GO:0048255)2.71329237
107protein K48-linked deubiquitination (GO:0071108)2.71169221
108phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70606476
109spindle checkpoint (GO:0031577)2.70579038
110reciprocal DNA recombination (GO:0035825)2.70283976
111reciprocal meiotic recombination (GO:0007131)2.70283976
112adaptation of signaling pathway (GO:0023058)2.70257056
113dopamine transport (GO:0015872)2.69773782
114regulation of sister chromatid cohesion (GO:0007063)2.69446089
115negative regulation of calcium ion transport into cytosol (GO:0010523)2.69433008
116translational elongation (GO:0006414)2.69218223
117telomere organization (GO:0032200)2.68184222
118DNA replication-dependent nucleosome assembly (GO:0006335)2.68058755
119DNA replication-dependent nucleosome organization (GO:0034723)2.68058755
120nuclear pore complex assembly (GO:0051292)2.67492740
121spindle assembly checkpoint (GO:0071173)2.67396353
122regulation of pigment cell differentiation (GO:0050932)2.66941494
123base-excision repair (GO:0006284)2.66463832
124nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66373465
125chromatin assembly or disassembly (GO:0006333)2.65514332
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.65330856
127negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65330856
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65330856
129negative regulation of sister chromatid segregation (GO:0033046)2.65330856
130DNA replication checkpoint (GO:0000076)2.64741113
131activated T cell proliferation (GO:0050798)2.64439148
132negative regulation of chromosome segregation (GO:0051985)2.64291364
133photoreceptor cell maintenance (GO:0045494)2.63228844
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.63055120
135regulation of mitotic metaphase/anaphase transition (GO:0030071)2.63046149
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.61339551
137positive regulation of alpha-beta T cell proliferation (GO:0046641)2.60585747
138positive regulation of developmental pigmentation (GO:0048087)2.60236411
139NAD biosynthetic process (GO:0009435)2.59477604
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.59418522
141establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58503370
142preassembly of GPI anchor in ER membrane (GO:0016254)2.57895370
143neutrophil activation involved in immune response (GO:0002283)2.57588807
144indole-containing compound metabolic process (GO:0042430)2.57465916
145platelet dense granule organization (GO:0060155)2.56497224
146organelle membrane fusion (GO:0090174)2.55997861
147mitotic spindle assembly checkpoint (GO:0007094)2.55571240
148behavioral response to nicotine (GO:0035095)2.55358166
149positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.53554218
150dosage compensation (GO:0007549)2.53374231
151regulation of establishment of cell polarity (GO:2000114)2.52914562
152histone mRNA catabolic process (GO:0071044)2.52807183
153mitotic spindle checkpoint (GO:0071174)2.51940993
154negative regulation of mRNA metabolic process (GO:1903312)2.51810374
155kinetochore assembly (GO:0051382)2.51793632
156regulation of meiosis I (GO:0060631)2.51474638
157DNA deamination (GO:0045006)2.51073479
158protein localization to endoplasmic reticulum (GO:0070972)2.50668433
159positive regulation of chromosome segregation (GO:0051984)2.50629157
160sulfation (GO:0051923)2.50499683
161positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49936538
162negative regulation of mRNA processing (GO:0050686)2.49916376
163interferon-gamma production (GO:0032609)2.48450616
164regulation of histone H3-K9 methylation (GO:0051570)2.47212749
165fusion of sperm to egg plasma membrane (GO:0007342)2.46909005
166chromosome segregation (GO:0007059)2.46145378
167response to pheromone (GO:0019236)2.45894838
168regulation of sister chromatid segregation (GO:0033045)2.45754870
169regulation of mitotic sister chromatid separation (GO:0010965)2.45754870
170regulation of mitotic sister chromatid segregation (GO:0033047)2.45754870
171mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44382617
172autophagic vacuole fusion (GO:0000046)2.44201863
173type B pancreatic cell development (GO:0003323)2.44054237
174regulation of mRNA stability (GO:0043488)2.43990580
175regulation of regulatory T cell differentiation (GO:0045589)2.43966124
176regulation of stem cell maintenance (GO:2000036)2.43603659
177monoubiquitinated protein deubiquitination (GO:0035520)2.43362186
178neutrophil activation (GO:0042119)2.43099393
179embryonic epithelial tube formation (GO:0001838)2.42682219
180pericardium development (GO:0060039)2.40866775
181positive regulation of keratinocyte differentiation (GO:0045618)2.40808814
182regulation of RNA stability (GO:0043487)2.40740426
183benzene-containing compound metabolic process (GO:0042537)2.39486641
184superoxide anion generation (GO:0042554)2.39358169
185signal peptide processing (GO:0006465)2.39167023
186negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.39135501
187positive regulation of defense response to virus by host (GO:0002230)2.39130513
188regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37446773
189rhodopsin mediated signaling pathway (GO:0016056)2.37298780
190regulation of inositol phosphate biosynthetic process (GO:0010919)2.36397069
191negative regulation of DNA-dependent DNA replication (GO:2000104)2.36177853
192positive regulation of cAMP-mediated signaling (GO:0043950)2.35938770
193cellular response to ethanol (GO:0071361)2.35131011
194cilium morphogenesis (GO:0060271)2.33587879
195thyroid hormone metabolic process (GO:0042403)2.30503747
196regulation of platelet aggregation (GO:0090330)2.30045860
197DNA dealkylation (GO:0035510)2.29474492
198mast cell degranulation (GO:0043303)2.29265527
199mast cell activation involved in immune response (GO:0002279)2.29265527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.61011955
2FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.72346459
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65145306
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.30543028
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.22208706
6VDR_22108803_ChIP-Seq_LS180_Human3.07616779
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.98692615
8GBX2_23144817_ChIP-Seq_PC3_Human2.82578068
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82460918
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68536092
11MYC_22102868_ChIP-Seq_BL_Human2.63690512
12ZNF274_21170338_ChIP-Seq_K562_Hela2.62082950
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57923952
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.47514527
15AR_21909140_ChIP-Seq_LNCAP_Human2.40342180
16IGF1R_20145208_ChIP-Seq_DFB_Human2.35758565
17* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35476561
18TAF15_26573619_Chip-Seq_HEK293_Human2.33385792
19EWS_26573619_Chip-Seq_HEK293_Human2.29967763
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18107444
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.12746923
22VDR_21846776_ChIP-Seq_THP-1_Human2.10515650
23P300_19829295_ChIP-Seq_ESCs_Human2.05204850
24ER_23166858_ChIP-Seq_MCF-7_Human2.05144135
25FUS_26573619_Chip-Seq_HEK293_Human2.04436896
26CIITA_25753668_ChIP-Seq_RAJI_Human2.04430917
27E2F7_22180533_ChIP-Seq_HELA_Human10.5629539
28XRN2_22483619_ChIP-Seq_HELA_Human1.98378073
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97367903
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97207041
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.95937599
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92456766
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92169085
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88475732
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86490877
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85330757
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83876518
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79920746
39* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79823439
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74063414
41SCL_19346495_ChIP-Seq_HPC-7_Human1.70934157
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70704614
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.70139107
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67925105
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67697360
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.64487685
47* EZH2_27294783_Chip-Seq_NPCs_Mouse1.64075135
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63507266
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62683580
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62449635
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.62254995
52STAT3_23295773_ChIP-Seq_U87_Human1.57232144
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56761051
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.55977032
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55809157
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55499316
57SMAD4_21799915_ChIP-Seq_A2780_Human1.54455091
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.54378603
59* VDR_23849224_ChIP-Seq_CD4+_Human1.54311256
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54099481
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52991926
62BCAT_22108803_ChIP-Seq_LS180_Human1.50994730
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50651271
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48691721
65CBP_20019798_ChIP-Seq_JUKART_Human1.45980986
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45980986
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44958289
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44593084
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.44474083
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43911008
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43071455
72VDR_24763502_ChIP-Seq_THP-1_Human1.41050255
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40953571
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.40867267
75TCF4_23295773_ChIP-Seq_U87_Human1.40823011
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40748007
77AR_25329375_ChIP-Seq_VCAP_Human1.39851192
78MYB_26560356_Chip-Seq_TH2_Human1.39829714
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39140606
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39019091
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38834526
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38590724
83* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38448703
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38436329
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36146665
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35908665
87SPI1_23547873_ChIP-Seq_NB4_Human1.35659410
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35619519
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34842631
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33956716
91* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33566195
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33295646
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.33284362
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.32784683
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32413840
96TTF2_22483619_ChIP-Seq_HELA_Human1.31865495
97* CRX_20693478_ChIP-Seq_RETINA_Mouse1.31815287
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31466356
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31378908
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31253556
101HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30702331
102IRF1_19129219_ChIP-ChIP_H3396_Human1.30436338
103ETS1_20019798_ChIP-Seq_JURKAT_Human1.30236159
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.29292720
105CDX2_22108803_ChIP-Seq_LS180_Human1.29080633
106MYB_26560356_Chip-Seq_TH1_Human1.29049031
107* FLI1_21867929_ChIP-Seq_TH2_Mouse1.28709028
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28116385
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27981124
110SOX2_19829295_ChIP-Seq_ESCs_Human1.27906795
111NANOG_19829295_ChIP-Seq_ESCs_Human1.27906795
112GABP_19822575_ChIP-Seq_HepG2_Human1.27277910
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26999453
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26999453
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26034502
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25914690
117KDM5A_27292631_Chip-Seq_BREAST_Human1.25806312
118TCF7_22412390_ChIP-Seq_EML_Mouse1.24984249
119TCF4_22108803_ChIP-Seq_LS180_Human1.24914114
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24467663
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24447103
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23195948
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23185028
124P53_22387025_ChIP-Seq_ESCs_Mouse1.23169608
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.23020199
126TP53_22573176_ChIP-Seq_HFKS_Human1.22150776
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.21138757
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20498680
129GATA3_26560356_Chip-Seq_TH2_Human1.20323892
130ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20050876
131DCP1A_22483619_ChIP-Seq_HELA_Human1.19558604
132* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18989811
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18853518
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18736163
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18540682
136UTX_26944678_Chip-Seq_JUKART_Human1.18193271
137RUNX_20019798_ChIP-Seq_JUKART_Human1.17832848
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.17280047
139E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17252015
140BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16728766
141SMAD4_21741376_ChIP-Seq_EPCs_Human1.16148301
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15583432
143SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14791639
144* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14733869
145* FOXA1_25329375_ChIP-Seq_VCAP_Human1.14733869
146RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14461309
147* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14307788
148* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14118265
149TP53_16413492_ChIP-PET_HCT116_Human1.14028690
150* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13609875
151EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13582660
152BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13276447
153* RUNX2_22187159_ChIP-Seq_PCA_Human1.13068624
154MAF_26560356_Chip-Seq_TH1_Human1.11909591
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11858600
156DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11341166
157POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10329555
158SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10229224
159CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10074376
160AR_20517297_ChIP-Seq_VCAP_Human1.09795755
161STAT3_18555785_Chip-Seq_ESCs_Mouse1.09198785
162ELK1_19687146_ChIP-ChIP_HELA_Human1.09045302
163NOTCH1_21737748_ChIP-Seq_TLL_Human1.08238109
164KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07602088
165JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07212406
166CMYC_18555785_Chip-Seq_ESCs_Mouse1.07060558
167GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05146788
168IRF8_21731497_ChIP-ChIP_J774_Mouse1.04542436
169P300_18555785_Chip-Seq_ESCs_Mouse1.04249356
170* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04239111
171PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02887304
172RUNX1_22412390_ChIP-Seq_EML_Mouse1.01059192
173GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98609332
174STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97447249
175STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96684388
176STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96187658
177YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96093832
178FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95712235
179DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94862582
180KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91474427
181NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90180165
182STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88722181
183MAF_26560356_Chip-Seq_TH2_Human0.83809527
184TFEB_21752829_ChIP-Seq_HELA_Human0.82295661
185PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78979181
186MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78875987
187CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78722220
188TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78469740
189E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78312284
190CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77976006
191ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.77715824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.29886981
2MP0010094_abnormal_chromosome_stability3.23584727
3MP0004147_increased_porphyrin_level2.78616529
4MP0003111_abnormal_nucleus_morphology2.76934632
5MP0000566_synostosis2.74000562
6MP0002102_abnormal_ear_morphology2.68818079
7MP0002396_abnormal_hematopoietic_system2.64882846
8MP0003077_abnormal_cell_cycle2.57655120
9MP0010352_gastrointestinal_tract_polyps2.55973099
10MP0008057_abnormal_DNA_replication2.54662758
11MP0004957_abnormal_blastocyst_morpholog2.53828027
12MP0003195_calcinosis2.41872958
13MP0002736_abnormal_nociception_after2.33974242
14MP0003724_increased_susceptibility_to2.29400358
15MP0008007_abnormal_cellular_replicative2.19076432
16MP0006054_spinal_hemorrhage2.15371871
17MP0008872_abnormal_physiological_respon2.15175809
18MP0010030_abnormal_orbit_morphology2.13449720
19MP0003300_gastrointestinal_ulcer2.03037110
20MP0000372_irregular_coat_pigmentation2.01255199
21MP0004808_abnormal_hematopoietic_stem1.98363485
22MP0001968_abnormal_touch/_nociception1.94432047
23MP0008058_abnormal_DNA_repair1.86975566
24MP0002009_preneoplasia1.80457368
25MP0003763_abnormal_thymus_physiology1.77322696
26MP0000490_abnormal_crypts_of1.75447046
27MP0002166_altered_tumor_susceptibility1.74636424
28MP0001835_abnormal_antigen_presentation1.72303974
29MP0005551_abnormal_eye_electrophysiolog1.72199104
30MP0005075_abnormal_melanosome_morpholog1.70554539
31MP0003787_abnormal_imprinting1.68204781
32MP0008932_abnormal_embryonic_tissue1.64899822
33MP0005646_abnormal_pituitary_gland1.63876152
34MP0001873_stomach_inflammation1.63042332
35MP0009278_abnormal_bone_marrow1.61564977
36MP0002653_abnormal_ependyma_morphology1.58479436
37MP0003718_maternal_effect1.55356812
38MP0000427_abnormal_hair_cycle1.54481099
39MP0009697_abnormal_copulation1.53923650
40MP0003646_muscle_fatigue1.53141925
41MP0000685_abnormal_immune_system1.49507147
42MP0008875_abnormal_xenobiotic_pharmacok1.49090238
43MP0000350_abnormal_cell_proliferation1.47680485
44MP0010307_abnormal_tumor_latency1.47565597
45MP0002148_abnormal_hypersensitivity_rea1.46953497
46MP0005167_abnormal_blood-brain_barrier1.42256724
47MP0004043_abnormal_pH_regulation1.41817850
48MP0002398_abnormal_bone_marrow1.39614734
49MP0005397_hematopoietic_system_phenotyp1.36920029
50MP0001545_abnormal_hematopoietic_system1.36920029
51MP0003183_abnormal_peptide_metabolism1.34446463
52MP0005253_abnormal_eye_physiology1.33875635
53MP0009053_abnormal_anal_canal1.33286602
54MP0003656_abnormal_erythrocyte_physiolo1.32915054
55MP0000230_abnormal_systemic_arterial1.32491682
56MP0005084_abnormal_gallbladder_morpholo1.32226617
57MP0001730_embryonic_growth_arrest1.31757260
58MP0000703_abnormal_thymus_morphology1.30948764
59MP0000015_abnormal_ear_pigmentation1.30562858
60MP0005410_abnormal_fertilization1.24457458
61MP0004264_abnormal_extraembryonic_tissu1.23101707
62MP0002877_abnormal_melanocyte_morpholog1.22937789
63MP0001293_anophthalmia1.22724511
64MP0009764_decreased_sensitivity_to1.21611320
65MP0008004_abnormal_stomach_pH1.21543522
66MP0005310_abnormal_salivary_gland1.17711594
67MP0004142_abnormal_muscle_tone1.17600064
68MP0003252_abnormal_bile_duct1.17537739
69MP0003283_abnormal_digestive_organ1.17356935
70MP0010155_abnormal_intestine_physiology1.16882462
71MP0002019_abnormal_tumor_incidence1.14892191
72MP0002006_tumorigenesis1.14446658
73MP0001800_abnormal_humoral_immune1.13672231
74MP0005076_abnormal_cell_differentiation1.12104873
75MP0005220_abnormal_exocrine_pancreas1.11717061
76MP0001697_abnormal_embryo_size1.11657766
77MP0009785_altered_susceptibility_to1.11346874
78MP0001929_abnormal_gametogenesis1.11238154
79MP0006276_abnormal_autonomic_nervous1.10973341
80MP0002722_abnormal_immune_system1.10829890
81MP0003984_embryonic_growth_retardation1.10306021
82MP0001672_abnormal_embryogenesis/_devel1.09006102
83MP0005380_embryogenesis_phenotype1.09006102
84MP0003045_fibrosis1.08942272
85MP0001501_abnormal_sleep_pattern1.08930817
86MP0000716_abnormal_immune_system1.08502016
87MP0002088_abnormal_embryonic_growth/wei1.08038939
88MP0002452_abnormal_antigen_presenting1.07888002
89MP0002138_abnormal_hepatobiliary_system1.07527737
90MP0002429_abnormal_blood_cell1.06697422
91MP0000689_abnormal_spleen_morphology1.06579352
92MP0005387_immune_system_phenotype1.06255956
93MP0003121_genomic_imprinting1.05836200
94MP0002420_abnormal_adaptive_immunity1.05377662
95MP0000383_abnormal_hair_follicle1.05198311
96MP0008877_abnormal_DNA_methylation1.04935750
97MP0009333_abnormal_splenocyte_physiolog1.04929240
98MP0005671_abnormal_response_to1.04479680
99MP0000313_abnormal_cell_death1.03845400
100MP0005645_abnormal_hypothalamus_physiol1.03826571
101MP0001819_abnormal_immune_cell1.03241863
102MP0000465_gastrointestinal_hemorrhage1.00792942
103MP0000569_abnormal_digit_pigmentation1.00541256
104MP0005085_abnormal_gallbladder_physiolo1.00484169
105MP0000858_altered_metastatic_potential0.99838768
106MP0002092_abnormal_eye_morphology0.99810077
107MP0002095_abnormal_skin_pigmentation0.99081364
108MP0001986_abnormal_taste_sensitivity0.98479777
109MP0002876_abnormal_thyroid_physiology0.98326016
110MP0002085_abnormal_embryonic_tissue0.98184859
111MP0003136_yellow_coat_color0.97505294
112MP0002938_white_spotting0.97228289
113MP0004197_abnormal_fetal_growth/weight/0.96702460
114MP0004215_abnormal_myocardial_fiber0.96314973
115MP0005083_abnormal_biliary_tract0.96083961
116MP0002086_abnormal_extraembryonic_tissu0.95358848
117MP0002080_prenatal_lethality0.94824751
118MP0005395_other_phenotype0.94646574
119MP0001485_abnormal_pinna_reflex0.94370148
120MP0003123_paternal_imprinting0.93694139
121MP0005174_abnormal_tail_pigmentation0.92951410
122MP0005025_abnormal_response_to0.92568506
123MP0003943_abnormal_hepatobiliary_system0.92455053
124MP0010386_abnormal_urinary_bladder0.92454079
125MP0002405_respiratory_system_inflammati0.92368273
126MP0002084_abnormal_developmental_patter0.91578110
127MP0002723_abnormal_immune_serum0.90698829
128MP0003436_decreased_susceptibility_to0.87466634
129MP0001919_abnormal_reproductive_system0.86419981
130MP0003890_abnormal_embryonic-extraembry0.84043810
131MP0004484_altered_response_of0.83700140
132MP0002210_abnormal_sex_determination0.83291733
133MP0009046_muscle_twitch0.82983748
134MP0005389_reproductive_system_phenotype0.82550748
135MP0002249_abnormal_larynx_morphology0.82474111
136MP0000477_abnormal_intestine_morphology0.81967023
137MP0005000_abnormal_immune_tolerance0.81843191
138MP0003866_abnormal_defecation0.81827352
139MP0005464_abnormal_platelet_physiology0.80942615
140MP0002837_dystrophic_cardiac_calcinosis0.80749984
141MP0005647_abnormal_sex_gland0.78495393
142MP0002928_abnormal_bile_duct0.78434053
143MP0009672_abnormal_birth_weight0.77621477
144MP0001845_abnormal_inflammatory_respons0.77218063
145MP0001145_abnormal_male_reproductive0.77117607
146MP0002168_other_aberrant_phenotype0.76232309
147MP0000428_abnormal_craniofacial_morphol0.76022892
148MP0003115_abnormal_respiratory_system0.74570273
149MP0002277_abnormal_respiratory_mucosa0.74357726
150MP0000049_abnormal_middle_ear0.73922003
151MP0001764_abnormal_homeostasis0.73639405
152MP0002419_abnormal_innate_immunity0.73361797
153MP0002733_abnormal_thermal_nociception0.73171130
154MP0003698_abnormal_male_reproductive0.71970567
155MP0008995_early_reproductive_senescence0.71059024
156MP0005257_abnormal_intraocular_pressure0.70438310
157MP0002932_abnormal_joint_morphology0.70403324
158MP0002282_abnormal_trachea_morphology0.69646807
159MP0003638_abnormal_response/metabolism_0.69001489
160MP0000653_abnormal_sex_gland0.68629645
161MP0010678_abnormal_skin_adnexa0.68182274
162MP0001119_abnormal_female_reproductive0.68149839
163MP0001790_abnormal_immune_system0.67132672

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.07327545
2Pancreatic fibrosis (HP:0100732)3.60917323
3Abnormality of midbrain morphology (HP:0002418)3.47437820
4Molar tooth sign on MRI (HP:0002419)3.47437820
5Colon cancer (HP:0003003)3.45590232
6True hermaphroditism (HP:0010459)3.41648529
7Reticulocytopenia (HP:0001896)3.34032537
8Abnormality of the renal cortex (HP:0011035)3.30811784
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.29237019
10Absent/shortened dynein arms (HP:0200106)3.29237019
11Congenital stationary night blindness (HP:0007642)3.20139156
12Attenuation of retinal blood vessels (HP:0007843)3.19259843
13Prolonged bleeding time (HP:0003010)3.05253279
14Abolished electroretinogram (ERG) (HP:0000550)2.97880001
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93079080
16Short 4th metacarpal (HP:0010044)2.93079080
17Stomatitis (HP:0010280)2.91019126
18Medulloblastoma (HP:0002885)2.84985762
19Increased nuchal translucency (HP:0010880)2.83446034
20Chromsome breakage (HP:0040012)2.80390584
21Renal cortical cysts (HP:0000803)2.80001947
22Volvulus (HP:0002580)2.74457953
23Abnormal ciliary motility (HP:0012262)2.73904658
24Decreased central vision (HP:0007663)2.72208480
25Aplastic anemia (HP:0001915)2.69580225
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68823826
27Gaze-evoked nystagmus (HP:0000640)2.68650319
28Chronic hepatic failure (HP:0100626)2.68233299
29Abnormal respiratory motile cilium morphology (HP:0005938)2.66521342
30Abnormal respiratory epithelium morphology (HP:0012253)2.66521342
31Optic nerve coloboma (HP:0000588)2.64172589
32Hyperventilation (HP:0002883)2.63616389
33Nephronophthisis (HP:0000090)2.62653378
3411 pairs of ribs (HP:0000878)2.60168588
35Medial flaring of the eyebrow (HP:0010747)2.58402756
36Abnormality of T cell number (HP:0011839)2.58177138
37Abnormality of the renal medulla (HP:0100957)2.57574029
38Thrombocytosis (HP:0001894)2.56457408
39Recurrent bronchitis (HP:0002837)2.53692412
40Thyroiditis (HP:0100646)2.51432695
41Abnormality of the fingertips (HP:0001211)2.47677905
42Abnormal respiratory motile cilium physiology (HP:0012261)2.42038164
43Nasal polyposis (HP:0100582)2.41022502
44Abnormal number of erythroid precursors (HP:0012131)2.40704764
45Bronchitis (HP:0012387)2.38596239
46Abnormality of chromosome stability (HP:0003220)2.36935210
47Spondylolisthesis (HP:0003302)2.34021897
48Stomach cancer (HP:0012126)2.33862143
49Partial duplication of the phalanx of hand (HP:0009999)2.31359900
50Partial duplication of thumb phalanx (HP:0009944)2.30498647
51Abnormality of cells of the erythroid lineage (HP:0012130)2.30367878
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28447319
53Abnormal number of incisors (HP:0011064)2.27522212
54Cystic liver disease (HP:0006706)2.27102426
55Increased mean platelet volume (HP:0011877)2.26709587
56Autoimmune hemolytic anemia (HP:0001890)2.22805860
57Dyschromatopsia (HP:0007641)2.22202208
58Abnormality of the nasal mucosa (HP:0000433)2.20828507
59Recurrent viral infections (HP:0004429)2.20639964
60Genetic anticipation (HP:0003743)2.18386702
61Hypoproteinemia (HP:0003075)2.17317946
62Abnormality of the preputium (HP:0100587)2.16854829
63Chronic bronchitis (HP:0004469)2.15951979
64Febrile seizures (HP:0002373)2.14608337
65Abnormal rod and cone electroretinograms (HP:0008323)2.13557761
66Petechiae (HP:0000967)2.09573142
67Agnosia (HP:0010524)2.09447690
68Proximal placement of thumb (HP:0009623)2.09108839
69IgG deficiency (HP:0004315)2.06079344
70Abnormal platelet volume (HP:0011876)2.05818175
71Thyroid-stimulating hormone excess (HP:0002925)2.04882140
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.03142076
73Epistaxis (HP:0000421)2.03087429
74Severe combined immunodeficiency (HP:0004430)2.03011868
75Polydipsia (HP:0001959)2.02197123
76Abnormal drinking behavior (HP:0030082)2.02197123
77Congenital hepatic fibrosis (HP:0002612)2.01604789
78Male pseudohermaphroditism (HP:0000037)2.00774192
79Ectopic kidney (HP:0000086)1.99543644
80Menorrhagia (HP:0000132)1.99485307
81Selective tooth agenesis (HP:0001592)1.98981894
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.98691815
83Gastrointestinal carcinoma (HP:0002672)1.97358202
84Malignant gastrointestinal tract tumors (HP:0006749)1.97358202
85Abnormality of the prostate (HP:0008775)1.97356671
86Neonatal death (HP:0003811)1.97044618
87Central scotoma (HP:0000603)1.96885175
88Myelodysplasia (HP:0002863)1.96642705
89Deviation of the thumb (HP:0009603)1.95335727
90Fair hair (HP:0002286)1.95197360
91Abnormality of the 4th metacarpal (HP:0010012)1.95164049
92Encephalitis (HP:0002383)1.94804120
93Poikilocytosis (HP:0004447)1.93912829
94Duodenal stenosis (HP:0100867)1.93640107
95Small intestinal stenosis (HP:0012848)1.93640107
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.92971772
97Bicuspid aortic valve (HP:0001647)1.92931010
98IgM deficiency (HP:0002850)1.92357999
99Spontaneous hematomas (HP:0007420)1.92071957
100Rhinitis (HP:0012384)1.92005506
101B lymphocytopenia (HP:0010976)1.91752910
102Abnormality of B cell number (HP:0010975)1.91752910
103Chronic otitis media (HP:0000389)1.91647396
104Tubular atrophy (HP:0000092)1.90922602
105Abnormality of cells of the lymphoid lineage (HP:0012140)1.89650989
106Abnormality of alanine metabolism (HP:0010916)1.89530297
107Hyperalaninemia (HP:0003348)1.89530297
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89530297
109Duplication of thumb phalanx (HP:0009942)1.89332798
110Decreased circulating renin level (HP:0003351)1.88282382
111Poikiloderma (HP:0001029)1.87865341
112Periodontitis (HP:0000704)1.87429334
113Atresia of the external auditory canal (HP:0000413)1.87281895
114Clumsiness (HP:0002312)1.87239779
115Acute lymphatic leukemia (HP:0006721)1.86685400
116Bony spicule pigmentary retinopathy (HP:0007737)1.86072673
117Abnormality of the anterior horn cell (HP:0006802)1.85984846
118Degeneration of anterior horn cells (HP:0002398)1.85984846
119Constricted visual fields (HP:0001133)1.85775203
120Cutis marmorata (HP:0000965)1.85666862
121Abnormality of eosinophils (HP:0001879)1.84803524
122Abnormality of macular pigmentation (HP:0008002)1.84767960
123Abnormal delayed hypersensitivity skin test (HP:0002963)1.83664750
124Congenital primary aphakia (HP:0007707)1.83353374
125Abnormality of T cell physiology (HP:0011840)1.82593442
126Type II lissencephaly (HP:0007260)1.81991301
127Chronic diarrhea (HP:0002028)1.81852901
128Widely spaced teeth (HP:0000687)1.81138302
129Abnormality of the right ventricle (HP:0001707)1.80901351
130Furrowed tongue (HP:0000221)1.80901312
131Cellulitis (HP:0100658)1.80808696
132Xerostomia (HP:0000217)1.79600030
133Cleft eyelid (HP:0000625)1.79232201
134Meckel diverticulum (HP:0002245)1.79168769
135Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79122514
136Acute myeloid leukemia (HP:0004808)1.78953069
137Abnormality of T cells (HP:0002843)1.77894654
138Abnormality of the ileum (HP:0001549)1.77104144
139Progressive inability to walk (HP:0002505)1.76802281
140Congenital sensorineural hearing impairment (HP:0008527)1.75982332
141Gastrointestinal inflammation (HP:0004386)1.75492468
142Retrobulbar optic neuritis (HP:0100654)1.75416253
143Optic neuritis (HP:0100653)1.75416253
144Abnormality of the carotid arteries (HP:0005344)1.75064296
145Gait imbalance (HP:0002141)1.74842310
146Rectal prolapse (HP:0002035)1.74308212
1473-Methylglutaconic aciduria (HP:0003535)1.74204023
148Pallor (HP:0000980)1.74051033
149Renal duplication (HP:0000075)1.73927590
150Eosinophilia (HP:0001880)1.73327408
151Heterotopia (HP:0002282)1.72922362
152Lymphoma (HP:0002665)1.72871709
153Nephrogenic diabetes insipidus (HP:0009806)1.72171556
154Absent speech (HP:0001344)1.71775611
155Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71743988
156Gingival bleeding (HP:0000225)1.70737701
157Panhypogammaglobulinemia (HP:0003139)1.70535912
158Abnormality of the duodenum (HP:0002246)1.70360823
159Keratoconjunctivitis (HP:0001096)1.70331730
160Genital tract atresia (HP:0001827)1.69899312
161Lymphopenia (HP:0001888)1.69736026
162Recurrent otitis media (HP:0000403)1.69710569
163Bile duct proliferation (HP:0001408)1.69494968
164Abnormal biliary tract physiology (HP:0012439)1.69494968
165Hypochromic microcytic anemia (HP:0004840)1.68582552
166Hyperacusis (HP:0010780)1.68282371
167Acanthocytosis (HP:0001927)1.68085811
168Postaxial foot polydactyly (HP:0001830)1.67924092
169Long eyelashes (HP:0000527)1.67415259
170Porencephaly (HP:0002132)1.66459959
171Bone marrow hypocellularity (HP:0005528)1.66246045
172T lymphocytopenia (HP:0005403)1.66194846
173Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.65932665
174Oral leukoplakia (HP:0002745)1.65021778
175Impulsivity (HP:0100710)1.64748082
176Basal cell carcinoma (HP:0002671)1.64514421
177Triphalangeal thumb (HP:0001199)1.64050271
178Recurrent bacterial skin infections (HP:0005406)1.64046150
179Sloping forehead (HP:0000340)1.63824860
180Uterine neoplasm (HP:0010784)1.63186954
181Inflammation of the large intestine (HP:0002037)1.62601937
182Clubbing of toes (HP:0100760)1.61193032
183Rhabdomyosarcoma (HP:0002859)1.61175113
184Limited elbow extension (HP:0001377)1.59598662
185Bronchiectasis (HP:0002110)1.58521288
186Transitional cell carcinoma of the bladder (HP:0006740)1.57486421
187Ependymoma (HP:0002888)1.57087644
188Recurrent abscess formation (HP:0002722)1.56907257
189Neoplasm of the pancreas (HP:0002894)1.56455990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.16087295
2BUB13.50771461
3EEF2K3.40616093
4CDC73.17471772
5MST42.89745783
6NEK22.83995271
7MAP3K102.73461438
8MAP4K12.38929400
9ADRBK22.38189981
10PASK2.38066449
11BMPR1B2.33201413
12MAP4K22.27861456
13WNK32.07755996
14ZAK1.91089331
15DYRK31.90709303
16WEE11.88953033
17TGFBR11.86794338
18CDK121.78191272
19CDK41.78122692
20EIF2AK31.75843678
21RPS6KA41.75786183
22OXSR11.68300439
23ATR1.68238850
24TTK1.63266175
25STK101.61778393
26TNIK1.56847189
27BRSK21.55724045
28TRIM281.52963389
29STK391.52262761
30FGFR31.48135843
31IRAK11.47850218
32MAPK131.46486863
33CDK61.42230975
34GRK11.41230100
35AURKB1.41127275
36PTK2B1.38228451
37BTK1.37684074
38CDK91.36811642
39CCNB11.36484176
40FLT31.36410959
41CDK81.34927062
42ACVR1B1.34054837
43EIF2AK11.32163945
44PLK11.30907190
45CDK71.26622080
46TAOK31.26524995
47KIT1.25245460
48TGFBR21.23590052
49RPS6KB21.22644002
50INSRR1.21550788
51STK31.17521981
52IRAK41.16926092
53TEC1.15945709
54MKNK11.15739715
55PIK3CG1.15394662
56CAMKK21.15281385
57PINK11.15087860
58LRRK21.14567899
59TESK11.13945469
60PKN21.13289783
61PAK41.13003088
62VRK11.10651053
63MELK1.08517474
64ERBB31.06563234
65PLK21.06065373
66ERN11.05655485
67ADRBK11.01614942
68PTK61.01441544
69BCR0.99001596
70CSF1R0.98430034
71CHEK20.97835173
72TYK20.94122136
73CHEK10.91554225
74SRPK10.91014558
75ITK0.90506690
76MAP3K80.89602841
77RIPK40.89191520
78SCYL20.88334682
79JAK30.87975054
80PLK40.87062646
81PIM10.86383273
82HIPK20.84471793
83IKBKB0.83917673
84NME20.83277044
85TRPM70.82634655
86KDR0.81338825
87WNK40.80764010
88DAPK20.80630860
89BMPR20.80376389
90STK40.78504929
91NEK90.77012194
92DYRK1B0.76928973
93PIK3CA0.75315120
94NLK0.75179844
95MAP3K40.74458740
96MARK30.74118295
97TNK20.73803784
98ATM0.73070825
99TESK20.73040677
100BRD40.71730864
101TRIB30.71569999
102MAPK150.71120118
103NUAK10.70714487
104CLK10.70434784
105FER0.70083265
106GRK50.69626741
107ZAP700.68165781
108TAF10.67837498
109PRKCQ0.64806263
110PNCK0.62820567
111PRKD30.62038482
112GRK70.61051450
113BRSK10.61044260
114MUSK0.61035060
115ERBB20.57608157
116MATK0.57484446
117CDK20.57440360
118TLK10.57151832
119MTOR0.56192060
120MAPKAPK20.56100248
121PAK30.55868379
122SIK30.54813639
123EIF2AK20.54782227
124BLK0.54204455
125IKBKE0.53550726
126PLK30.52518741
127BCKDK0.52078655
128SYK0.51656022
129EPHA30.50920205
130CDK30.50853120
131GRK60.49399557
132CHUK0.49150959
133HCK0.49046995
134PRKCE0.48700367
135LYN0.46847032
136CDK190.45641410
137FGR0.45457486
138LCK0.45022440
139MAP3K60.44913231
140PRKG20.44768709
141TXK0.43928781
142CASK0.43917426
143STK38L0.43896191
144AKT30.43867285
145AURKA0.43062619
146LATS10.42504298
147MKNK20.41834898
148MAPKAPK50.41546552
149MAPKAPK30.41246571
150CDK10.40557098
151MAP2K30.40102039
152YES10.38804526
153PKN10.38344565
154CSNK2A20.38069608
155IGF1R0.37175931
156FES0.36621176
157CSNK2A10.36491253
158CSNK1G10.36149095
159CSNK1A1L0.35560151
160SGK20.35389452
161MYLK0.34189510
162BMX0.33227857
163PRKAA20.32329202
164PRKG10.30092042
165ABL10.28476673

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.33800324
2Mismatch repair_Homo sapiens_hsa034303.99126622
3Base excision repair_Homo sapiens_hsa034103.36712920
4Nitrogen metabolism_Homo sapiens_hsa009102.99371853
5Cell cycle_Homo sapiens_hsa041102.91498984
6Homologous recombination_Homo sapiens_hsa034402.66478566
7Spliceosome_Homo sapiens_hsa030402.64003388
8Linoleic acid metabolism_Homo sapiens_hsa005912.48150146
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.43201769
10Phototransduction_Homo sapiens_hsa047442.42359559
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.36478916
12Ribosome_Homo sapiens_hsa030102.28119662
13Nucleotide excision repair_Homo sapiens_hsa034202.27453885
14Caffeine metabolism_Homo sapiens_hsa002322.16676336
15RNA transport_Homo sapiens_hsa030132.07718736
16Fanconi anemia pathway_Homo sapiens_hsa034602.00353050
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92969790
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80675327
19Antigen processing and presentation_Homo sapiens_hsa046121.79316563
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.77640204
21Non-homologous end-joining_Homo sapiens_hsa034501.77029786
22Arachidonic acid metabolism_Homo sapiens_hsa005901.72625452
23Pyrimidine metabolism_Homo sapiens_hsa002401.65576431
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.63497382
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62814241
26Ether lipid metabolism_Homo sapiens_hsa005651.62189013
27One carbon pool by folate_Homo sapiens_hsa006701.58479914
28RNA degradation_Homo sapiens_hsa030181.57694753
29Tryptophan metabolism_Homo sapiens_hsa003801.55346081
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.52660127
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52045718
32Primary immunodeficiency_Homo sapiens_hsa053401.48515713
33p53 signaling pathway_Homo sapiens_hsa041151.46551209
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46420623
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45177155
36ABC transporters_Homo sapiens_hsa020101.44876532
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.43741414
38Olfactory transduction_Homo sapiens_hsa047401.43459218
39Protein export_Homo sapiens_hsa030601.43378547
40Notch signaling pathway_Homo sapiens_hsa043301.42282089
41mRNA surveillance pathway_Homo sapiens_hsa030151.39802092
42Graft-versus-host disease_Homo sapiens_hsa053321.39404235
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34186644
44Butanoate metabolism_Homo sapiens_hsa006501.33869040
45Basal transcription factors_Homo sapiens_hsa030221.31613998
46HTLV-I infection_Homo sapiens_hsa051661.28588174
47Propanoate metabolism_Homo sapiens_hsa006401.28311559
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27483325
49Allograft rejection_Homo sapiens_hsa053301.23533838
50Chemical carcinogenesis_Homo sapiens_hsa052041.22488128
51Herpes simplex infection_Homo sapiens_hsa051681.22428596
52N-Glycan biosynthesis_Homo sapiens_hsa005101.20361698
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19969281
54Selenocompound metabolism_Homo sapiens_hsa004501.19629463
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.18592867
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18376250
57Viral carcinogenesis_Homo sapiens_hsa052031.16343922
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16068182
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15972056
60Serotonergic synapse_Homo sapiens_hsa047261.14961915
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09817173
62Autoimmune thyroid disease_Homo sapiens_hsa053201.09330838
63Basal cell carcinoma_Homo sapiens_hsa052171.07940299
64Regulation of autophagy_Homo sapiens_hsa041401.06295208
65Small cell lung cancer_Homo sapiens_hsa052221.05875659
66NF-kappa B signaling pathway_Homo sapiens_hsa040641.05523992
67MicroRNAs in cancer_Homo sapiens_hsa052061.04520995
68Glycerolipid metabolism_Homo sapiens_hsa005611.04385202
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04280531
70Chronic myeloid leukemia_Homo sapiens_hsa052201.03889634
71Hepatitis B_Homo sapiens_hsa051611.01087400
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00998890
73Epstein-Barr virus infection_Homo sapiens_hsa051691.00821292
74Taste transduction_Homo sapiens_hsa047421.00762110
75B cell receptor signaling pathway_Homo sapiens_hsa046620.98946871
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.97613068
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97294146
78RNA polymerase_Homo sapiens_hsa030200.96665706
79Systemic lupus erythematosus_Homo sapiens_hsa053220.94732253
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92368808
81Retinol metabolism_Homo sapiens_hsa008300.91977851
82Measles_Homo sapiens_hsa051620.91146632
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88389936
84Pancreatic cancer_Homo sapiens_hsa052120.87472956
85Legionellosis_Homo sapiens_hsa051340.87016707
86Peroxisome_Homo sapiens_hsa041460.86258761
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83759258
88Lysine degradation_Homo sapiens_hsa003100.81161246
89Type I diabetes mellitus_Homo sapiens_hsa049400.80964819
90Histidine metabolism_Homo sapiens_hsa003400.78618079
91Colorectal cancer_Homo sapiens_hsa052100.77724056
92Purine metabolism_Homo sapiens_hsa002300.75523339
93Hedgehog signaling pathway_Homo sapiens_hsa043400.75502201
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74930208
95Sulfur metabolism_Homo sapiens_hsa009200.74296180
96Apoptosis_Homo sapiens_hsa042100.73044199
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70942800
98Pentose phosphate pathway_Homo sapiens_hsa000300.70476388
99Morphine addiction_Homo sapiens_hsa050320.70346750
100Osteoclast differentiation_Homo sapiens_hsa043800.69707529
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.67582461
102beta-Alanine metabolism_Homo sapiens_hsa004100.66329163
103Leishmaniasis_Homo sapiens_hsa051400.66300253
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66165741
105Hematopoietic cell lineage_Homo sapiens_hsa046400.65944200
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65322537
107Adherens junction_Homo sapiens_hsa045200.65141567
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.64589168
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.63954562
110Oocyte meiosis_Homo sapiens_hsa041140.63125896
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62221491
112Salivary secretion_Homo sapiens_hsa049700.60610375
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59180449
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.57971992
115Bladder cancer_Homo sapiens_hsa052190.56588448
116Thyroid cancer_Homo sapiens_hsa052160.55841186
117Rheumatoid arthritis_Homo sapiens_hsa053230.54283449
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54268140
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.53603060
120Renin-angiotensin system_Homo sapiens_hsa046140.53590768
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53359668
122Acute myeloid leukemia_Homo sapiens_hsa052210.52737556
123Viral myocarditis_Homo sapiens_hsa054160.52591895
124Influenza A_Homo sapiens_hsa051640.51904516
125Pathways in cancer_Homo sapiens_hsa052000.51175468
126Calcium signaling pathway_Homo sapiens_hsa040200.51073239
127Collecting duct acid secretion_Homo sapiens_hsa049660.50528484
128Ovarian steroidogenesis_Homo sapiens_hsa049130.49768402
129Glutathione metabolism_Homo sapiens_hsa004800.49746918
130Chemokine signaling pathway_Homo sapiens_hsa040620.49715046
131Shigellosis_Homo sapiens_hsa051310.49690713
132Sphingolipid metabolism_Homo sapiens_hsa006000.49618599
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49116996
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.48744562
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48441091
136Dorso-ventral axis formation_Homo sapiens_hsa043200.48375983
137Folate biosynthesis_Homo sapiens_hsa007900.48215635
138Nicotine addiction_Homo sapiens_hsa050330.48081909
139Toxoplasmosis_Homo sapiens_hsa051450.46421717
140Hippo signaling pathway_Homo sapiens_hsa043900.45643853
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44984050
142Proteasome_Homo sapiens_hsa030500.44567917
143Fat digestion and absorption_Homo sapiens_hsa049750.44244939
144Non-small cell lung cancer_Homo sapiens_hsa052230.44171979
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43601175
146Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43234111
147Pancreatic secretion_Homo sapiens_hsa049720.41812646
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40923604
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39499658
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38293202
151Prostate cancer_Homo sapiens_hsa052150.38225133
152TGF-beta signaling pathway_Homo sapiens_hsa043500.37531157
153RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36988261
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35529087
155T cell receptor signaling pathway_Homo sapiens_hsa046600.35106267
156Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35043690
157Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33834822
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33030921
159Wnt signaling pathway_Homo sapiens_hsa043100.32511224
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31030809
161Asthma_Homo sapiens_hsa053100.30146435
162Platelet activation_Homo sapiens_hsa046110.29296995

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