POC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.78854338
2protein localization to kinetochore (GO:0034501)4.49304044
3DNA double-strand break processing (GO:0000729)4.48935351
4mitotic metaphase plate congression (GO:0007080)4.44397497
5mitotic chromosome condensation (GO:0007076)4.42199602
6protein localization to chromosome, centromeric region (GO:0071459)4.21069696
7centriole replication (GO:0007099)4.18706324
8mitotic sister chromatid segregation (GO:0000070)4.16071121
9DNA ligation (GO:0006266)4.12995990
10kinetochore assembly (GO:0051382)4.12784455
11regulation of DNA endoreduplication (GO:0032875)3.99324065
12synapsis (GO:0007129)3.96220706
13regulation of spindle organization (GO:0090224)3.93145910
14sister chromatid segregation (GO:0000819)3.87844134
15resolution of meiotic recombination intermediates (GO:0000712)3.73253814
16attachment of spindle microtubules to kinetochore (GO:0008608)3.70819535
17metaphase plate congression (GO:0051310)3.70212491
18proteasome assembly (GO:0043248)3.68328415
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68023244
20DNA catabolic process, exonucleolytic (GO:0000738)3.60980719
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56234521
22regulation of mitotic spindle organization (GO:0060236)3.54691611
23protein localization to chromosome (GO:0034502)3.52865713
24cullin deneddylation (GO:0010388)3.51622988
25mitotic sister chromatid cohesion (GO:0007064)3.50168848
26protein deneddylation (GO:0000338)3.49776382
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49565643
28establishment of integrated proviral latency (GO:0075713)3.48335684
29establishment of chromosome localization (GO:0051303)3.48288836
30regulation of centriole replication (GO:0046599)3.48166439
31DNA replication-dependent nucleosome assembly (GO:0006335)3.44476218
32DNA replication-dependent nucleosome organization (GO:0034723)3.44476218
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44091274
34rRNA modification (GO:0000154)3.40902784
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.37583547
36cilium or flagellum-dependent cell motility (GO:0001539)3.35733671
37positive regulation of chromosome segregation (GO:0051984)3.34768369
38replication fork processing (GO:0031297)3.32882183
39DNA strand elongation involved in DNA replication (GO:0006271)3.31712299
40regulation of mitotic spindle checkpoint (GO:1903504)3.31020836
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.31020836
42piRNA metabolic process (GO:0034587)3.30393345
43telomere maintenance via semi-conservative replication (GO:0032201)3.27902078
44mitotic G2/M transition checkpoint (GO:0044818)3.27654223
45DNA topological change (GO:0006265)3.22447214
46synaptonemal complex assembly (GO:0007130)3.20571201
47regulation of chromosome segregation (GO:0051983)3.20343232
48negative regulation of DNA recombination (GO:0045910)3.19469109
49mitotic recombination (GO:0006312)3.18030350
50DNA strand elongation (GO:0022616)3.17908863
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17857485
52histone exchange (GO:0043486)3.16748524
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16168026
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15889498
55mitotic nuclear envelope disassembly (GO:0007077)3.15572661
56male meiosis (GO:0007140)3.15328889
57positive regulation of histone H3-K4 methylation (GO:0051571)3.14699201
58synaptonemal complex organization (GO:0070193)3.14211307
59non-recombinational repair (GO:0000726)3.13997977
60double-strand break repair via nonhomologous end joining (GO:0006303)3.13997977
61DNA replication-independent nucleosome assembly (GO:0006336)3.12899264
62DNA replication-independent nucleosome organization (GO:0034724)3.12899264
63negative regulation of ligase activity (GO:0051352)3.11919745
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11919745
65nuclear envelope disassembly (GO:0051081)3.10933859
66membrane disassembly (GO:0030397)3.10933859
67spindle checkpoint (GO:0031577)3.09910103
68viral mRNA export from host cell nucleus (GO:0046784)3.08933486
69chromosome segregation (GO:0007059)3.05695037
70CENP-A containing nucleosome assembly (GO:0034080)3.05633099
71histone mRNA metabolic process (GO:0008334)3.05617760
72positive regulation of ligase activity (GO:0051351)3.04990281
73regulation of exit from mitosis (GO:0007096)3.03868293
74centriole assembly (GO:0098534)3.02364626
75regulation of centrosome cycle (GO:0046605)3.01990767
76RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01707005
77microtubule polymerization or depolymerization (GO:0031109)3.00828581
78meiosis I (GO:0007127)3.00521712
79chromatin remodeling at centromere (GO:0031055)2.99324462
80rRNA methylation (GO:0031167)2.98938287
81ribosome assembly (GO:0042255)2.98792757
82DNA replication initiation (GO:0006270)2.98564804
83nucleotide-excision repair, DNA gap filling (GO:0006297)2.98476974
84nuclear pore organization (GO:0006999)2.95581589
85regulation of short-term neuronal synaptic plasticity (GO:0048172)2.95335975
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93966017
87regulation of telomere maintenance via telomerase (GO:0032210)2.92716140
88mitotic G2 DNA damage checkpoint (GO:0007095)2.92539660
89meiotic nuclear division (GO:0007126)2.85778833
90protein complex localization (GO:0031503)2.85525231
91positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.84649750
92chromosome condensation (GO:0030261)2.83829469
93male meiosis I (GO:0007141)2.83428958
94mitotic spindle checkpoint (GO:0071174)2.83179618
95DNA unwinding involved in DNA replication (GO:0006268)2.82866927
96negative regulation of histone methylation (GO:0031061)2.82725514
97protein K6-linked ubiquitination (GO:0085020)2.80955653
98negative regulation of organelle assembly (GO:1902116)2.80769306
99histone H2A acetylation (GO:0043968)2.80605254
100negative regulation of chromosome segregation (GO:0051985)2.79303247
101nuclear pore complex assembly (GO:0051292)2.79108725
102kinetochore organization (GO:0051383)2.77083790
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.76830484
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76830484
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76830484
106negative regulation of sister chromatid segregation (GO:0033046)2.76830484
107spindle assembly checkpoint (GO:0071173)2.76823098
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76591892
109synaptic vesicle exocytosis (GO:0016079)2.76161805
110mitotic spindle assembly checkpoint (GO:0007094)2.75541264
111positive regulation of mitotic sister chromatid separation (GO:1901970)2.73328169
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73328169
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73328169
114meiotic chromosome segregation (GO:0045132)2.71195480
115regulation of chromatin binding (GO:0035561)2.71105514
116microtubule depolymerization (GO:0007019)2.70624606
117microtubule severing (GO:0051013)2.69854187
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68888590
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68884720
120synaptic vesicle docking involved in exocytosis (GO:0016081)2.68310837
121mitotic spindle organization (GO:0007052)2.67962232
122chromatin assembly or disassembly (GO:0006333)2.67948494
123meiotic cell cycle process (GO:1903046)2.67085805
124postreplication repair (GO:0006301)2.64524354
125regulation of mitotic sister chromatid separation (GO:0010965)2.64250740
126regulation of mitotic sister chromatid segregation (GO:0033047)2.64250740
127regulation of sister chromatid segregation (GO:0033045)2.64250740
128regulation of sister chromatid cohesion (GO:0007063)2.63477764
129cilium movement (GO:0003341)2.62776722
130axonemal dynein complex assembly (GO:0070286)2.60199902
131synaptic vesicle maturation (GO:0016188)2.58634269
132peptidyl-arginine N-methylation (GO:0035246)2.58307600
133peptidyl-arginine methylation (GO:0018216)2.58307600
134meiotic cell cycle (GO:0051321)2.57945109
135DNA replication checkpoint (GO:0000076)2.57602448
136regulation of cilium movement (GO:0003352)2.57051887
137nuclear envelope organization (GO:0006998)2.56823486
138protein polyglutamylation (GO:0018095)2.54171799
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.53946170
140glutamate secretion (GO:0014047)2.53261004
141regulation of meiosis I (GO:0060631)2.53246456
142regulation of RNA export from nucleus (GO:0046831)2.49350892
143DNA packaging (GO:0006323)2.48646493
144peptidyl-arginine omega-N-methylation (GO:0035247)2.47556232
145mitotic cell cycle (GO:0000278)2.47515987
146ATP-dependent chromatin remodeling (GO:0043044)2.43072954
147monoubiquitinated protein deubiquitination (GO:0035520)2.42542727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.67011590
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.10231530
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.49135816
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30634690
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03930735
6ELK1_19687146_ChIP-ChIP_HELA_Human2.99834042
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81620189
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69791240
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69145149
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66435221
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37613566
12EZH2_22144423_ChIP-Seq_EOC_Human2.35739851
13AR_21909140_ChIP-Seq_LNCAP_Human2.26298332
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.20974138
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.11649110
16HOXB4_20404135_ChIP-ChIP_EML_Mouse2.09023245
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.07076696
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05313775
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94435526
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92876132
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92399682
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.90393434
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.88795614
24CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.87861157
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86663117
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85332454
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84384647
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82638130
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78699360
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78439706
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78007270
32XRN2_22483619_ChIP-Seq_HELA_Human1.76168687
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69572633
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69566402
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68649836
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67614625
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66414528
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.65257703
39GABP_19822575_ChIP-Seq_HepG2_Human1.64479025
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64144256
41CIITA_25753668_ChIP-Seq_RAJI_Human1.59901396
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58463621
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57800468
44EWS_26573619_Chip-Seq_HEK293_Human1.57333418
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54741603
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.54430564
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52341857
48VDR_23849224_ChIP-Seq_CD4+_Human1.49931689
49* KDM5A_27292631_Chip-Seq_BREAST_Human1.49401047
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46183585
51MYC_18940864_ChIP-ChIP_HL60_Human1.45722387
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.43283347
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42812671
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40657132
55FUS_26573619_Chip-Seq_HEK293_Human1.39537549
56* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39415959
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39098348
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.37088223
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34736641
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34528896
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32465669
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32237567
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31611314
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31360234
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30897037
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29965364
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.29835053
68DCP1A_22483619_ChIP-Seq_HELA_Human1.28984127
69ZNF274_21170338_ChIP-Seq_K562_Hela1.27360277
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25542608
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22557857
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22499968
73* GATA1_26923725_Chip-Seq_HPCs_Mouse1.22189882
74IGF1R_20145208_ChIP-Seq_DFB_Human1.20793323
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.19961291
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.19526119
77REST_21632747_ChIP-Seq_MESCs_Mouse1.17409494
78MYC_22102868_ChIP-Seq_BL_Human1.17362750
79CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15673753
80IRF1_19129219_ChIP-ChIP_H3396_Human1.14951462
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13910507
82* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13589567
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.13180818
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13080382
85FOXP3_21729870_ChIP-Seq_TREG_Human1.12734406
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11185908
87TTF2_22483619_ChIP-Seq_HELA_Human1.10123939
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10049251
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08451200
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07471769
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07193153
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07132390
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04230811
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.03798729
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03221287
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00102411
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99753182
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99448689
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98955426
100TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97990884
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97783162
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97547129
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94920759
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94579254
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94198153
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91637762
107TP63_19390658_ChIP-ChIP_HaCaT_Human0.91279694
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90844918
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90803029
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90695435
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90344978
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89971486
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88883005
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88613424
115ZNF263_19887448_ChIP-Seq_K562_Human0.88553293
116NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86086912
117SALL4_22934838_ChIP-ChIP_CD34+_Human0.84968427
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84825299
119VDR_22108803_ChIP-Seq_LS180_Human0.84185393
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83537751
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.82964837
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80458361
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79695832
124EGR1_19374776_ChIP-ChIP_THP-1_Human0.79316678
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.78139897
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77681840
127POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.77610830
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.77263847
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77249041
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77100680
131TP53_22573176_ChIP-Seq_HFKS_Human0.76658129
132* SPI1_23547873_ChIP-Seq_NB4_Human0.76348127
133TAF15_26573619_Chip-Seq_HEK293_Human0.75950642
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75212964
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73711473
136TFEB_21752829_ChIP-Seq_HELA_Human0.73671257
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73241182
138FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73131783
139SOX2_16153702_ChIP-ChIP_HESCs_Human0.72813391
140* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72738794
141WDR5_24793694_ChIP-Seq_LNCAP_Human0.72730189
142POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.71656867
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71242674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.62859809
2MP0004859_abnormal_synaptic_plasticity3.62363044
3MP0002653_abnormal_ependyma_morphology3.54230139
4MP0003111_abnormal_nucleus_morphology3.47739185
5MP0008877_abnormal_DNA_methylation3.27604483
6MP0010094_abnormal_chromosome_stability3.21100133
7MP0003077_abnormal_cell_cycle2.81938016
8MP0004957_abnormal_blastocyst_morpholog2.69869958
9MP0009697_abnormal_copulation2.23982273
10MP0004270_analgesia2.23175883
11MP0003123_paternal_imprinting2.15437088
12MP0003635_abnormal_synaptic_transmissio2.09595790
13MP0005075_abnormal_melanosome_morpholog2.06673740
14MP0000372_irregular_coat_pigmentation1.99964501
15MP0001730_embryonic_growth_arrest1.93293999
16MP0006035_abnormal_mitochondrial_morpho1.91708931
17MP0001929_abnormal_gametogenesis1.89575991
18MP0000569_abnormal_digit_pigmentation1.89263510
19MP0008057_abnormal_DNA_replication1.86625898
20MP0005410_abnormal_fertilization1.82837295
21MP0002396_abnormal_hematopoietic_system1.82418858
22MP0008058_abnormal_DNA_repair1.82410530
23MP0003787_abnormal_imprinting1.74242451
24MP0003698_abnormal_male_reproductive1.71322244
25MP0008932_abnormal_embryonic_tissue1.67725544
26MP0000350_abnormal_cell_proliferation1.67609134
27MP0002734_abnormal_mechanical_nocicepti1.67018438
28MP0009046_muscle_twitch1.63390028
29MP0002210_abnormal_sex_determination1.61918488
30MP0000778_abnormal_nervous_system1.59230759
31MP0008007_abnormal_cellular_replicative1.57465337
32MP0001984_abnormal_olfaction1.56898084
33MP0002063_abnormal_learning/memory/cond1.56737552
34MP0003121_genomic_imprinting1.51610086
35MP0005394_taste/olfaction_phenotype1.49495789
36MP0005499_abnormal_olfactory_system1.49495789
37MP0008789_abnormal_olfactory_epithelium1.48506723
38MP0006072_abnormal_retinal_apoptosis1.47159160
39MP0002064_seizures1.45506985
40MP0005084_abnormal_gallbladder_morpholo1.45303615
41MP0002184_abnormal_innervation1.44678144
42MP0002102_abnormal_ear_morphology1.41983549
43MP0001697_abnormal_embryo_size1.41512239
44MP0008995_early_reproductive_senescence1.41440270
45MP0003861_abnormal_nervous_system1.40855891
46MP0004811_abnormal_neuron_physiology1.40838912
47MP0001145_abnormal_male_reproductive1.40761209
48MP0005423_abnormal_somatic_nervous1.39550730
49MP0002084_abnormal_developmental_patter1.37555831
50MP0003880_abnormal_central_pattern1.36439706
51MP0002085_abnormal_embryonic_tissue1.34859749
52MP0000653_abnormal_sex_gland1.31462770
53MP0004147_increased_porphyrin_level1.30462096
54MP0006036_abnormal_mitochondrial_physio1.29703268
55MP0002161_abnormal_fertility/fecundity1.28409541
56MP0010307_abnormal_tumor_latency1.26862982
57MP0003186_abnormal_redox_activity1.26575624
58MP0003718_maternal_effect1.26417335
59MP0001968_abnormal_touch/_nociception1.26410858
60MP0002152_abnormal_brain_morphology1.25817432
61MP0002160_abnormal_reproductive_system1.25639814
62MP0009745_abnormal_behavioral_response1.24640026
63MP0005174_abnormal_tail_pigmentation1.24240005
64MP0001188_hyperpigmentation1.22946582
65MP0002272_abnormal_nervous_system1.20614055
66MP0001529_abnormal_vocalization1.19398162
67MP0002019_abnormal_tumor_incidence1.18588727
68MP0005395_other_phenotype1.18024313
69MP0002080_prenatal_lethality1.17704881
70MP0000955_abnormal_spinal_cord1.16921356
71MP0002882_abnormal_neuron_morphology1.16502776
72MP0001672_abnormal_embryogenesis/_devel1.16225137
73MP0005380_embryogenesis_phenotype1.16225137
74MP0003656_abnormal_erythrocyte_physiolo1.14873033
75MP0001293_anophthalmia1.14627558
76MP0002095_abnormal_skin_pigmentation1.13481579
77MP0001119_abnormal_female_reproductive1.12131370
78MP0005551_abnormal_eye_electrophysiolog1.11599448
79MP0006292_abnormal_olfactory_placode1.11414541
80MP0000015_abnormal_ear_pigmentation1.11389662
81MP0004808_abnormal_hematopoietic_stem1.10616481
82MP0003943_abnormal_hepatobiliary_system1.09856499
83MP0002572_abnormal_emotion/affect_behav1.07053526
84MP0005623_abnormal_meninges_morphology1.06024158
85MP0000703_abnormal_thymus_morphology1.04040221
86MP0000631_abnormal_neuroendocrine_gland1.03576512
87MP0003806_abnormal_nucleotide_metabolis1.02640460
88MP0000516_abnormal_urinary_system1.02625938
89MP0005367_renal/urinary_system_phenotyp1.02625938
90MP0001486_abnormal_startle_reflex1.00315623
91MP0004233_abnormal_muscle_weight0.99191459
92MP0003984_embryonic_growth_retardation0.99076199
93MP0002088_abnormal_embryonic_growth/wei0.96799146
94MP0008569_lethality_at_weaning0.96280799
95MP0003890_abnormal_embryonic-extraembry0.95861616
96MP0005076_abnormal_cell_differentiation0.95641111
97MP0003315_abnormal_perineum_morphology0.95375238
98MP0002067_abnormal_sensory_capabilities0.94190075
99MP0001919_abnormal_reproductive_system0.93548328
100MP0003786_premature_aging0.93419518
101MP0002398_abnormal_bone_marrow0.91975576
102MP0010030_abnormal_orbit_morphology0.91900730
103MP0002638_abnormal_pupillary_reflex0.91526096
104MP0003329_amyloid_beta_deposits0.90678771
105MP0005253_abnormal_eye_physiology0.87297124
106MP0002752_abnormal_somatic_nervous0.87214883
107MP0000689_abnormal_spleen_morphology0.85581884
108MP0005646_abnormal_pituitary_gland0.85512809
109MP0001970_abnormal_pain_threshold0.83460662
110MP0003646_muscle_fatigue0.82485401
111MP0002066_abnormal_motor_capabilities/c0.82469518
112MP0002733_abnormal_thermal_nociception0.82384002
113MP0000427_abnormal_hair_cycle0.82039134
114MP0002163_abnormal_gland_morphology0.81867577
115MP0003567_abnormal_fetal_cardiomyocyte0.80492230
116MP0003699_abnormal_female_reproductive0.80442193
117MP0004924_abnormal_behavior0.79882779
118MP0005386_behavior/neurological_phenoty0.79882779
119MP0002751_abnormal_autonomic_nervous0.79209384
120MP0002086_abnormal_extraembryonic_tissu0.79008311
121MP0005187_abnormal_penis_morphology0.77938842
122MP0002938_white_spotting0.77417672
123MP0002722_abnormal_immune_system0.77318050
124MP0000358_abnormal_cell_content/0.76896437
125MP0001835_abnormal_antigen_presentation0.76702173
126MP0000647_abnormal_sebaceous_gland0.76684725
127MP0000313_abnormal_cell_death0.76500042
128MP0001485_abnormal_pinna_reflex0.76486391
129MP0005389_reproductive_system_phenotype0.75582915
130MP0002735_abnormal_chemical_nociception0.74849397
131MP0002736_abnormal_nociception_after0.74825430
132MP0001440_abnormal_grooming_behavior0.74513200
133MP0005384_cellular_phenotype0.73188927
134MP0001764_abnormal_homeostasis0.72818249
135MP0002557_abnormal_social/conspecific_i0.72154194
136MP0005408_hypopigmentation0.71852851
137MP0005621_abnormal_cell_physiology0.71475415
138MP0009703_decreased_birth_body0.71114241
139MP0004197_abnormal_fetal_growth/weight/0.71027625
140MP0003763_abnormal_thymus_physiology0.69956226
141MP0001324_abnormal_eye_pigmentation0.69938164
142MP0000490_abnormal_crypts_of0.69363144
143MP0001727_abnormal_embryo_implantation0.69278635
144MP0008873_increased_physiological_sensi0.66068330
145MP0002138_abnormal_hepatobiliary_system0.64127796
146MP0003011_delayed_dark_adaptation0.63553694
147MP0001286_abnormal_eye_development0.62035590
148MP0002429_abnormal_blood_cell0.61808656

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.71226733
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.20998801
3Chromsome breakage (HP:0040012)4.12475597
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.92652368
5Facial hemangioma (HP:0000329)3.40376536
6Cerebral hypomyelination (HP:0006808)3.31571910
7Chronic bronchitis (HP:0004469)3.24782336
8Abnormality of the lower motor neuron (HP:0002366)3.20502184
9Abnormal respiratory motile cilium physiology (HP:0012261)3.19036259
10Abnormal lung lobation (HP:0002101)3.16061663
11Rhinitis (HP:0012384)3.11410480
12Birth length less than 3rd percentile (HP:0003561)3.11381881
13Small intestinal stenosis (HP:0012848)3.11126453
14Duodenal stenosis (HP:0100867)3.11126453
15Acute necrotizing encephalopathy (HP:0006965)3.07112040
16Abnormality of the preputium (HP:0100587)3.03943730
17Acute encephalopathy (HP:0006846)2.85392620
18Myokymia (HP:0002411)2.79172878
19Myelodysplasia (HP:0002863)2.78034890
20Combined immunodeficiency (HP:0005387)2.74577055
21Mitochondrial inheritance (HP:0001427)2.69312453
22Abnormality of the duodenum (HP:0002246)2.68524658
23Increased CSF lactate (HP:0002490)2.65290225
24Progressive macrocephaly (HP:0004481)2.62640858
25Amyotrophic lateral sclerosis (HP:0007354)2.61945650
26Breast hypoplasia (HP:0003187)2.61740935
27Patellar aplasia (HP:0006443)2.61592500
28Abnormal mitochondria in muscle tissue (HP:0008316)2.58305163
29Increased hepatocellular lipid droplets (HP:0006565)2.58155116
30Carpal bone hypoplasia (HP:0001498)2.57469504
31Severe combined immunodeficiency (HP:0004430)2.56230931
32Aplastic anemia (HP:0001915)2.55286713
33Nephroblastoma (Wilms tumor) (HP:0002667)2.51925783
34Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44966088
35Aplasia/Hypoplasia of the patella (HP:0006498)2.44885995
36Lipid accumulation in hepatocytes (HP:0006561)2.43192616
373-Methylglutaconic aciduria (HP:0003535)2.43084496
38Absent/shortened dynein arms (HP:0200106)2.42086904
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.42086904
40Embryonal renal neoplasm (HP:0011794)2.37673911
41Cerebral edema (HP:0002181)2.35933024
42Hepatocellular necrosis (HP:0001404)2.34952924
43Abnormality of methionine metabolism (HP:0010901)2.34829348
44Pelvic girdle muscle weakness (HP:0003749)2.34434140
45Methylmalonic acidemia (HP:0002912)2.34374719
46CNS hypomyelination (HP:0003429)2.34317672
47Abnormality of the musculature of the pelvis (HP:0001469)2.34037177
48Abnormality of the hip-girdle musculature (HP:0001445)2.34037177
49Clubbing of toes (HP:0100760)2.33680926
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.32193384
51Abnormal ciliary motility (HP:0012262)2.32070075
52Impulsivity (HP:0100710)2.30653386
53Shoulder girdle muscle weakness (HP:0003547)2.30341555
54Abnormal respiratory epithelium morphology (HP:0012253)2.29201995
55Abnormal respiratory motile cilium morphology (HP:0005938)2.29201995
56Abnormality of B cell number (HP:0010975)2.28704700
57Supernumerary spleens (HP:0009799)2.28281156
58Increased serum lactate (HP:0002151)2.28191687
59Degeneration of anterior horn cells (HP:0002398)2.24146856
60Abnormality of the anterior horn cell (HP:0006802)2.24146856
61Focal motor seizures (HP:0011153)2.22973719
62Atrophy/Degeneration involving motor neurons (HP:0007373)2.22663778
63Volvulus (HP:0002580)2.22270970
64Oligodactyly (HP:0012165)2.20899377
65Visual hallucinations (HP:0002367)2.20744926
66Colon cancer (HP:0003003)2.18326734
67Cortical dysplasia (HP:0002539)2.17199758
68B lymphocytopenia (HP:0010976)2.17154125
69Unsteady gait (HP:0002317)2.15474434
70Bony spicule pigmentary retinopathy (HP:0007737)2.13997047
71Abnormality of alanine metabolism (HP:0010916)2.12013851
72Hyperalaninemia (HP:0003348)2.12013851
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12013851
74Focal seizures (HP:0007359)2.11117069
75Gait imbalance (HP:0002141)2.10930370
76Hepatic necrosis (HP:0002605)2.10904802
77Median cleft lip (HP:0000161)2.08632179
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08229893
79Infertility (HP:0000789)2.07476085
80IgM deficiency (HP:0002850)2.07088583
81Renal cortical cysts (HP:0000803)2.06935266
82Male infertility (HP:0003251)2.04090446
83Pancreatic cysts (HP:0001737)2.02017614
84Rhabdomyosarcoma (HP:0002859)2.01416381
85Truncal ataxia (HP:0002078)2.00867063
86Renal Fanconi syndrome (HP:0001994)1.99375535
87Intestinal atresia (HP:0011100)1.98866318
88Pancreatic fibrosis (HP:0100732)1.98563005
89Broad distal phalanx of finger (HP:0009836)1.97102718
90Lactic acidosis (HP:0003128)1.97065288
91Ependymoma (HP:0002888)1.96936042
92Microvesicular hepatic steatosis (HP:0001414)1.96527024
93Abnormality of midbrain morphology (HP:0002418)1.95749567
94Molar tooth sign on MRI (HP:0002419)1.95749567
95Neoplasm of the colon (HP:0100273)1.95204419
96Sloping forehead (HP:0000340)1.94958920
97Impaired smooth pursuit (HP:0007772)1.94910643
98Abnormality of ocular smooth pursuit (HP:0000617)1.94909991
99Abnormality of the pons (HP:0007361)1.93695605
100Bone marrow hypocellularity (HP:0005528)1.92621583
101Pancytopenia (HP:0001876)1.91945706
102Breast aplasia (HP:0100783)1.91421035
103Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91273904
104Tubulointerstitial nephritis (HP:0001970)1.90727073
105Heterotopia (HP:0002282)1.89065276
106Abnormal hair whorl (HP:0010721)1.88737189
107Spinal muscular atrophy (HP:0007269)1.88578740
108Aplasia/Hypoplasia of the uvula (HP:0010293)1.87318878
109Short tibia (HP:0005736)1.87278760
110Abnormal spermatogenesis (HP:0008669)1.86569766
111Papillary thyroid carcinoma (HP:0002895)1.86241917
112Congenital primary aphakia (HP:0007707)1.85338198
113Panhypogammaglobulinemia (HP:0003139)1.85271234
114Horseshoe kidney (HP:0000085)1.84536866
115Absent epiphyses (HP:0010577)1.84510833
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84510833
117Central scotoma (HP:0000603)1.84125265
118Mutism (HP:0002300)1.83719409
119Reticulocytopenia (HP:0001896)1.83523848
120Atonic seizures (HP:0010819)1.81556344
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81377086
122Abnormal protein N-linked glycosylation (HP:0012347)1.81377086
123Abnormal protein glycosylation (HP:0012346)1.81377086
124Abnormal glycosylation (HP:0012345)1.81377086
125Oligodactyly (hands) (HP:0001180)1.81357033
126Cellular immunodeficiency (HP:0005374)1.81151382
127Increased nuchal translucency (HP:0010880)1.80844497
128Microglossia (HP:0000171)1.80712571
129Aplasia/Hypoplasia of the breasts (HP:0010311)1.80548299
130Congenital stationary night blindness (HP:0007642)1.80111253
131Methylmalonic aciduria (HP:0012120)1.78109135
132Thyroiditis (HP:0100646)1.77650154
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77485709
134Short 4th metacarpal (HP:0010044)1.77485709
135Deep palmar crease (HP:0006191)1.77458182
136Medial flaring of the eyebrow (HP:0010747)1.77347108
137Ankle clonus (HP:0011448)1.76774329
138Abnormality of chromosome stability (HP:0003220)1.76599416
139Pointed chin (HP:0000307)1.76489138
140Respiratory difficulties (HP:0002880)1.76435480
141Absent thumb (HP:0009777)1.75026273
142Abnormality of serum amino acid levels (HP:0003112)1.74796170
143Secondary amenorrhea (HP:0000869)1.74721547
144Glioma (HP:0009733)1.74164213
145Hypoplasia of the pons (HP:0012110)1.72999212
146Exertional dyspnea (HP:0002875)1.72611078
147Cafe-au-lait spot (HP:0000957)1.72334488
148Neoplasm of the oral cavity (HP:0100649)1.72119812
149Progressive cerebellar ataxia (HP:0002073)1.71993191
150Nephrogenic diabetes insipidus (HP:0009806)1.71489972
151Limb hypertonia (HP:0002509)1.70731113
152Nephronophthisis (HP:0000090)1.70471925
153Delusions (HP:0000746)1.69010174
154Meckel diverticulum (HP:0002245)1.68682151
155Overlapping toe (HP:0001845)1.68679617
156Abnormality of DNA repair (HP:0003254)1.68570817
157Abnormality of the astrocytes (HP:0100707)1.68431443
158Astrocytoma (HP:0009592)1.68431443
159Abnormality of chromosome segregation (HP:0002916)1.68357719
160Truncal obesity (HP:0001956)1.67878446
161Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67609395
162Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67609395
163Neutropenia (HP:0001875)1.66444646
164Medulloblastoma (HP:0002885)1.65611077
165Poor coordination (HP:0002370)1.65534101
166Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65036808
167Impaired vibration sensation in the lower limbs (HP:0002166)1.63987899
168Peripheral hypomyelination (HP:0007182)1.63911660
169Aplasia/Hypoplasia of the tongue (HP:0010295)1.63007902
170Abnormality of abdominal situs (HP:0011620)1.61755670
171Abdominal situs inversus (HP:0003363)1.61755670
172Abnormality of the ileum (HP:0001549)1.59926981
173Abnormality of the labia (HP:0000058)1.58896031
174Prominent nose (HP:0000448)1.58542144
175Urinary urgency (HP:0000012)1.57765605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.54875780
2PBK3.14212800
3MAP3K93.02922398
4WEE13.02264425
5PNCK3.00087029
6NEK22.89099680
7CCNB12.56576346
8CDC72.54717195
9MST42.43195542
10NEK12.37898386
11TTK2.30474476
12TRIM282.24635554
13MAP3K42.23841972
14MARK12.23336782
15KSR12.23066182
16NUAK12.21513297
17ZAK2.18607459
18PLK42.17226494
19MAP4K22.15970065
20PDK42.05749802
21PDK32.05749802
22KSR22.01846749
23BRSK11.96415811
24DYRK31.87297340
25PRKD31.83424592
26NTRK21.73250791
27LATS21.72275941
28BMPR1B1.70813104
29PAK61.67869133
30BRSK21.65424763
31PLK11.65194872
32TAOK31.64248129
33PLK31.59794180
34VRK21.51108348
35STK161.49735260
36MELK1.49481068
37ARAF1.48874498
38MKNK11.46308139
39MKNK21.41740247
40MINK11.39354776
41SCYL21.39340588
42CHEK21.37782215
43BRAF1.35895380
44SRPK11.35082726
45MAP2K71.27765468
46TAOK11.24893648
47EEF2K1.24849537
48EIF2AK11.21415910
49WNK31.17027531
50ACVR1B1.16932039
51AURKA1.16884987
52EIF2AK21.15812278
53TSSK61.12420049
54MAP3K121.10245238
55STK101.05516312
56TNIK1.04134683
57CHEK11.04042309
58STK381.03749528
59DYRK21.02283513
60RAF10.98373724
61CDK180.96935982
62CDK140.96208234
63STK40.96174069
64CDK150.94741515
65TYRO30.91964445
66CLK10.91962750
67CAMKK10.91292401
68SIK30.90823643
69PDK20.89823516
70NTRK30.89584691
71ATR0.85671740
72AURKB0.84655778
73NTRK10.84161000
74CDK11A0.82365481
75MAP3K80.81981831
76STK30.81815585
77BCKDK0.73253574
78MAPK130.73250391
79TESK20.73036594
80CDK20.72602712
81ALK0.72501556
82CAMKK20.69003987
83CDK70.68735024
84STK38L0.68414175
85CDK10.68012551
86EPHA40.66861553
87STK110.66656597
88BRD40.66595682
89CSNK1G20.65755215
90TLK10.65257248
91LMTK20.62749460
92STK240.61939873
93CDK30.61326864
94ICK0.61031000
95ATM0.59853509
96PLK20.59599042
97VRK10.59369866
98TEC0.57841868
99DAPK20.57077080
100CDK50.56203930
101PRKCG0.55863470
102TESK10.54438187
103CSNK1G30.53506009
104FLT30.53263319
105CDK80.52874978
106CSNK1G10.52126995
107MAPK100.51651014
108BCR0.50785618
109KIT0.50320990
110CDK40.49678826
111CSNK2A20.47724302
112SGK4940.45899453
113SGK2230.45899453
114RET0.45407873
115DYRK1A0.44959615
116MAP3K100.43524033
117LIMK10.42668333
118MAP2K40.42368835
119CSNK2A10.41434870
120TRIB30.41311113
121RPS6KA40.40759578
122GSK3B0.40085510
123TAF10.40058428
124CSNK1E0.39885011
125DAPK10.37884472
126NEK60.37337020
127PRKCI0.37280962
128TGFBR10.36100344
129ERBB30.34429635
130PASK0.34286947
131PAK10.34204956
132EIF2AK30.33788874
133CSNK1A1L0.33211568
134CDK90.33008339
135NME10.31999280
136PKN10.31931102
137UHMK10.31391806
138TXK0.30774028
139MARK30.30665097
140FRK0.30524440
141PAK30.30382918
142RPS6KB20.30214298
143SGK20.30125551
144ILK0.28980610
145PRKACB0.28179998
146LYN0.25151325
147MAP3K50.22005464
148PIK3CG0.20639538
149EGFR0.20421510

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.97834004
2Cell cycle_Homo sapiens_hsa041102.86783117
3Oocyte meiosis_Homo sapiens_hsa041142.69695823
4RNA transport_Homo sapiens_hsa030132.52347429
5Vitamin B6 metabolism_Homo sapiens_hsa007502.35345617
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24998568
7Oxidative phosphorylation_Homo sapiens_hsa001902.23557289
8DNA replication_Homo sapiens_hsa030302.22843675
9Basal transcription factors_Homo sapiens_hsa030222.13858354
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.13425531
11Ribosome_Homo sapiens_hsa030102.11939977
12Synaptic vesicle cycle_Homo sapiens_hsa047212.11479539
13Parkinsons disease_Homo sapiens_hsa050122.05713359
14Spliceosome_Homo sapiens_hsa030401.96044352
15mRNA surveillance pathway_Homo sapiens_hsa030151.93468741
16RNA polymerase_Homo sapiens_hsa030201.92236029
17Mismatch repair_Homo sapiens_hsa034301.91792394
18Olfactory transduction_Homo sapiens_hsa047401.79770539
19Homologous recombination_Homo sapiens_hsa034401.72637243
20Propanoate metabolism_Homo sapiens_hsa006401.62344609
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61912454
22Huntingtons disease_Homo sapiens_hsa050161.56976446
23Long-term potentiation_Homo sapiens_hsa047201.55116023
24Fanconi anemia pathway_Homo sapiens_hsa034601.55004403
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49355827
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47914080
27Nucleotide excision repair_Homo sapiens_hsa034201.46561216
28RNA degradation_Homo sapiens_hsa030181.43062468
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39982606
30Nicotine addiction_Homo sapiens_hsa050331.38092934
31Amphetamine addiction_Homo sapiens_hsa050311.35504575
32Dopaminergic synapse_Homo sapiens_hsa047281.33787127
33Phototransduction_Homo sapiens_hsa047441.33360461
34Base excision repair_Homo sapiens_hsa034101.31687905
35Alcoholism_Homo sapiens_hsa050341.29575899
36Colorectal cancer_Homo sapiens_hsa052101.26032051
37GABAergic synapse_Homo sapiens_hsa047271.25578205
38Fatty acid elongation_Homo sapiens_hsa000621.23137866
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23066194
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22584266
41Glutamatergic synapse_Homo sapiens_hsa047241.21185759
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20470457
43mTOR signaling pathway_Homo sapiens_hsa041501.16171170
44Circadian entrainment_Homo sapiens_hsa047131.14394836
45Steroid biosynthesis_Homo sapiens_hsa001001.13298206
46Circadian rhythm_Homo sapiens_hsa047101.12720571
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11170361
48Pyrimidine metabolism_Homo sapiens_hsa002401.09095908
49Morphine addiction_Homo sapiens_hsa050321.08489448
50Alzheimers disease_Homo sapiens_hsa050101.07197046
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.05741550
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03095345
53Epstein-Barr virus infection_Homo sapiens_hsa051691.03014932
54Selenocompound metabolism_Homo sapiens_hsa004501.02976913
55Primary immunodeficiency_Homo sapiens_hsa053401.02254293
56Proteasome_Homo sapiens_hsa030501.00343709
57Renal cell carcinoma_Homo sapiens_hsa052111.00080331
58Estrogen signaling pathway_Homo sapiens_hsa049150.97061093
59p53 signaling pathway_Homo sapiens_hsa041150.95682587
60Purine metabolism_Homo sapiens_hsa002300.95628706
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95347936
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94196970
63Gap junction_Homo sapiens_hsa045400.93450150
64Cholinergic synapse_Homo sapiens_hsa047250.93331243
65Glioma_Homo sapiens_hsa052140.91357787
66Endometrial cancer_Homo sapiens_hsa052130.90370716
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90145079
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89594560
69GnRH signaling pathway_Homo sapiens_hsa049120.88360249
70Insulin secretion_Homo sapiens_hsa049110.85999046
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85175196
72Oxytocin signaling pathway_Homo sapiens_hsa049210.85036922
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83160307
74Hippo signaling pathway_Homo sapiens_hsa043900.82470895
75Cocaine addiction_Homo sapiens_hsa050300.81712507
76Long-term depression_Homo sapiens_hsa047300.80671251
77Viral carcinogenesis_Homo sapiens_hsa052030.79627238
78ErbB signaling pathway_Homo sapiens_hsa040120.78140487
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76763629
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75202430
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74191043
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71613994
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70636530
84Non-homologous end-joining_Homo sapiens_hsa034500.68666672
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.67753216
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67745442
87Endocytosis_Homo sapiens_hsa041440.67486768
88Choline metabolism in cancer_Homo sapiens_hsa052310.67307219
89VEGF signaling pathway_Homo sapiens_hsa043700.67097046
90Pancreatic cancer_Homo sapiens_hsa052120.65981067
91Pyruvate metabolism_Homo sapiens_hsa006200.65779859
92Gastric acid secretion_Homo sapiens_hsa049710.63467559
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.62805366
94Systemic lupus erythematosus_Homo sapiens_hsa053220.62584642
95Non-small cell lung cancer_Homo sapiens_hsa052230.62185160
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61443529
97FoxO signaling pathway_Homo sapiens_hsa040680.61220645
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61147867
99One carbon pool by folate_Homo sapiens_hsa006700.60781576
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59236303
101Chronic myeloid leukemia_Homo sapiens_hsa052200.58880911
102Dorso-ventral axis formation_Homo sapiens_hsa043200.58842538
103MicroRNAs in cancer_Homo sapiens_hsa052060.58484828
104Glutathione metabolism_Homo sapiens_hsa004800.57646271
105Glucagon signaling pathway_Homo sapiens_hsa049220.56331216
106Folate biosynthesis_Homo sapiens_hsa007900.55751783
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.55093689
108Inositol phosphate metabolism_Homo sapiens_hsa005620.53842449
109Collecting duct acid secretion_Homo sapiens_hsa049660.53350611
110Herpes simplex infection_Homo sapiens_hsa051680.53159610
111Salivary secretion_Homo sapiens_hsa049700.52848941
112HTLV-I infection_Homo sapiens_hsa051660.52146887
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51115391
114TGF-beta signaling pathway_Homo sapiens_hsa043500.50342591
115Regulation of autophagy_Homo sapiens_hsa041400.50046957
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.50035810
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49902782
118MAPK signaling pathway_Homo sapiens_hsa040100.49562966
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49524531
120Tight junction_Homo sapiens_hsa045300.49187107
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48526591
122Insulin signaling pathway_Homo sapiens_hsa049100.47999398
123Serotonergic synapse_Homo sapiens_hsa047260.46240594
124AMPK signaling pathway_Homo sapiens_hsa041520.46216757
125Wnt signaling pathway_Homo sapiens_hsa043100.45891434
126Hedgehog signaling pathway_Homo sapiens_hsa043400.45550144
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44560658
128Metabolic pathways_Homo sapiens_hsa011000.44439062
129Type II diabetes mellitus_Homo sapiens_hsa049300.44029217
130Axon guidance_Homo sapiens_hsa043600.43997310
131Sulfur metabolism_Homo sapiens_hsa009200.41562774
132N-Glycan biosynthesis_Homo sapiens_hsa005100.37892804
133Antigen processing and presentation_Homo sapiens_hsa046120.33214566
134Peroxisome_Homo sapiens_hsa041460.32317483
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27089158
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26737828
137Carbon metabolism_Homo sapiens_hsa012000.26274888
138Caffeine metabolism_Homo sapiens_hsa002320.26164428
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26047586
140Measles_Homo sapiens_hsa051620.22084919
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21602023
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.21229722
143Type I diabetes mellitus_Homo sapiens_hsa049400.20399181
144Shigellosis_Homo sapiens_hsa051310.19416845
145Allograft rejection_Homo sapiens_hsa053300.17875176
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17012307
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16820093
148Autoimmune thyroid disease_Homo sapiens_hsa053200.16583445
1492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15652329
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15634280
151Asthma_Homo sapiens_hsa053100.14908272
152Butanoate metabolism_Homo sapiens_hsa006500.12786358
153Legionellosis_Homo sapiens_hsa051340.12420938
154Intestinal immune network for IgA production_Homo sapiens_hsa046720.11313694
155Graft-versus-host disease_Homo sapiens_hsa053320.11000376
156Hepatitis B_Homo sapiens_hsa051610.10469367
157Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09945681
158Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09892084
159Thyroid cancer_Homo sapiens_hsa052160.09809165
160Biosynthesis of amino acids_Homo sapiens_hsa012300.08091603
161Hematopoietic cell lineage_Homo sapiens_hsa046400.07199195
162Cardiac muscle contraction_Homo sapiens_hsa042600.06487397
163Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.02859575

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