PODN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the small leucine-rich repeat protein family and contains an amino terminal CX3CXCX7C cysteine-rich cluster followed by a leucine-rich repeat domain. Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type B pancreatic cell proliferation (GO:0044342)5.91667720
2cell migration involved in heart development (GO:0060973)5.44379099
3protein heterotrimerization (GO:0070208)5.10483387
4peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.05555337
5regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.88382883
6collagen fibril organization (GO:0030199)4.44154330
7negative regulation of smooth muscle cell migration (GO:0014912)4.35816106
8regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.10950217
9kidney mesenchyme development (GO:0072074)4.05662997
10tooth mineralization (GO:0034505)3.98483738
11keratan sulfate catabolic process (GO:0042340)3.88935903
12carnitine shuttle (GO:0006853)3.88360300
13bone trabecula formation (GO:0060346)3.86572508
14dermatan sulfate metabolic process (GO:0030205)3.84954610
15low-density lipoprotein particle clearance (GO:0034383)3.84346658
16positive regulation of fatty acid beta-oxidation (GO:0032000)3.80988616
17dermatan sulfate biosynthetic process (GO:0030208)3.80746791
18positive regulation of fatty acid oxidation (GO:0046321)3.79367455
19fatty acid transmembrane transport (GO:1902001)3.79149861
20extracellular matrix assembly (GO:0085029)3.78287790
21mesenchymal-epithelial cell signaling (GO:0060638)3.77718746
22endocardial cushion development (GO:0003197)3.69613813
23regulation of sequestering of triglyceride (GO:0010889)3.54302160
24barbed-end actin filament capping (GO:0051016)3.53663869
25retina vasculature morphogenesis in camera-type eye (GO:0061299)3.44509913
26extracellular fibril organization (GO:0043206)3.42058546
27adhesion of symbiont to host cell (GO:0044650)3.38987413
28virion attachment to host cell (GO:0019062)3.38987413
29smooth muscle tissue development (GO:0048745)3.37380085
30sequestering of extracellular ligand from receptor (GO:0035581)3.35854130
31valine metabolic process (GO:0006573)3.29850734
32cellular response to vitamin (GO:0071295)3.22744207
33multicellular organismal macromolecule metabolic process (GO:0044259)3.22327292
34fatty acid beta-oxidation (GO:0006635)3.21780928
35cell proliferation involved in metanephros development (GO:0072203)3.21718472
36collagen metabolic process (GO:0032963)3.20995988
37middle ear morphogenesis (GO:0042474)3.18725747
38multicellular organismal metabolic process (GO:0044236)3.17119203
39cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.16713326
40regulation of fatty acid oxidation (GO:0046320)3.16574285
41negative regulation of leukocyte chemotaxis (GO:0002689)3.11191766
42biotin metabolic process (GO:0006768)3.10352360
43apoptotic cell clearance (GO:0043277)3.08805513
44collagen catabolic process (GO:0030574)3.08194016
45cardiac myofibril assembly (GO:0055003)3.05457697
46adhesion of symbiont to host (GO:0044406)3.04264669
47venous blood vessel morphogenesis (GO:0048845)3.04156481
48chondroitin sulfate catabolic process (GO:0030207)3.03623330
49multicellular organismal catabolic process (GO:0044243)3.02822337
50axon extension involved in axon guidance (GO:0048846)3.01771851
51neuron projection extension involved in neuron projection guidance (GO:1902284)3.01771851
52carnitine transmembrane transport (GO:1902603)3.01715258
53plasma membrane repair (GO:0001778)3.01235351
54amino-acid betaine transport (GO:0015838)3.00060840
55carnitine transport (GO:0015879)3.00060840
56protein localization to cell surface (GO:0034394)2.98856458
57extracellular matrix organization (GO:0030198)2.97882591
58extracellular structure organization (GO:0043062)2.96799571
59regulation of fatty acid beta-oxidation (GO:0031998)2.96036047
60stress fiber assembly (GO:0043149)2.95652779
61regulation of integrin-mediated signaling pathway (GO:2001044)2.95134421
62basement membrane organization (GO:0071711)2.94535106
63fibril organization (GO:0097435)2.94116144
64positive regulation of glycogen biosynthetic process (GO:0045725)2.89962362
65hyaluronan catabolic process (GO:0030214)2.88795294
66glomerular basement membrane development (GO:0032836)2.87529470
67endodermal cell differentiation (GO:0035987)2.87168345
68regulation of extracellular matrix disassembly (GO:0010715)2.84647077
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84263224
70sarcomere organization (GO:0045214)2.83333016
71regulation of plasminogen activation (GO:0010755)2.83020304
72white fat cell differentiation (GO:0050872)2.82226633
73vascular endothelial growth factor signaling pathway (GO:0038084)2.81185460
74negative regulation of BMP signaling pathway (GO:0030514)2.81101549
75glomerular filtration (GO:0003094)2.80763041
76skin morphogenesis (GO:0043589)2.80091135
77brown fat cell differentiation (GO:0050873)2.78970409
78fatty acid oxidation (GO:0019395)2.78785925
79regulation of skeletal muscle contraction (GO:0014819)2.77838338
80positive regulation of p38MAPK cascade (GO:1900745)2.77708723
81positive regulation of fibroblast migration (GO:0010763)2.77600905
82regulation of p38MAPK cascade (GO:1900744)2.75163506
83blood vessel maturation (GO:0001955)2.73749877
84extracellular negative regulation of signal transduction (GO:1900116)2.73539244
85extracellular regulation of signal transduction (GO:1900115)2.73539244
86regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.73171539
87regulation of smooth muscle cell migration (GO:0014910)2.72870015
88lipid oxidation (GO:0034440)2.72261454
89positive regulation of fatty acid metabolic process (GO:0045923)2.68739653
90glycosaminoglycan catabolic process (GO:0006027)2.67955291
91outer ear morphogenesis (GO:0042473)2.67152108
92fatty acid catabolic process (GO:0009062)2.66972516
93negative regulation of chondrocyte differentiation (GO:0032331)2.65574987
94insulin-like growth factor receptor signaling pathway (GO:0048009)2.65361786
95negative regulation of fatty acid transport (GO:2000192)2.64772176
96endothelial cell morphogenesis (GO:0001886)2.64756179
97complement activation, alternative pathway (GO:0006957)2.64415334
98negative regulation of cardiac muscle tissue growth (GO:0055022)2.63580906
99negative regulation of heart growth (GO:0061117)2.63580906
100epithelial cell-cell adhesion (GO:0090136)2.63288701
101lipid particle organization (GO:0034389)2.63158834
102myofibril assembly (GO:0030239)2.62524608
103trabecula formation (GO:0060343)2.62424800
104extracellular matrix disassembly (GO:0022617)2.61627518
105positive regulation of glycogen metabolic process (GO:0070875)2.60859315
106chondrocyte proliferation (GO:0035988)2.60727651
107positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.59725318
108regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59613671
109cell proliferation involved in kidney development (GO:0072111)2.59230843
1102-oxoglutarate metabolic process (GO:0006103)2.57246344
111regulation of tight junction assembly (GO:2000810)2.57053718
112pericardium development (GO:0060039)2.56680650
113growth hormone receptor signaling pathway (GO:0060396)2.56289532
114renal filtration (GO:0097205)2.56261637
115triglyceride catabolic process (GO:0019433)2.54683539
116phagocytosis, recognition (GO:0006910)2.53913409
117artery morphogenesis (GO:0048844)2.52403845
118cGMP-mediated signaling (GO:0019934)2.51753736
119positive regulation of gastrulation (GO:2000543)2.51707643
120tricarboxylic acid metabolic process (GO:0072350)2.51663840
121regulation of collagen metabolic process (GO:0010712)2.51432803
122mesenchymal cell differentiation involved in renal system development (GO:2001012)2.51160021
123mesenchymal cell differentiation involved in kidney development (GO:0072161)2.51160021
124embryo implantation (GO:0007566)2.49228019
125lysine metabolic process (GO:0006553)2.48696063
126lysine catabolic process (GO:0006554)2.48696063
127negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.46595003
128muscle cell migration (GO:0014812)2.46206173
129regulation of phospholipase A2 activity (GO:0032429)2.46152279
130positive regulation of mesenchymal cell proliferation (GO:0002053)2.45746324
131cell-substrate junction assembly (GO:0007044)2.44985174
132positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.44797017
133intracellular lipid transport (GO:0032365)2.44724007
134oxaloacetate metabolic process (GO:0006107)2.44650274
135quaternary ammonium group transport (GO:0015697)2.43880441
136bundle of His cell to Purkinje myocyte communication (GO:0086069)2.43812529
137epoxygenase P450 pathway (GO:0019373)2.43755406
138cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.43184289
139cell migration involved in sprouting angiogenesis (GO:0002042)2.42978856
140regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.42740344
141branched-chain amino acid metabolic process (GO:0009081)2.42169137
142fibroblast migration (GO:0010761)2.40888938
143negative regulation of complement activation (GO:0045916)2.40581425
144aminoglycan catabolic process (GO:0006026)2.39880580
145tricarboxylic acid cycle (GO:0006099)2.39699596
146negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.39439514
147metanephric mesenchyme development (GO:0072075)2.39385759
148negative regulation of smooth muscle cell proliferation (GO:0048662)2.39199161
149lung vasculature development (GO:0060426)2.38476413
150negative regulation of cartilage development (GO:0061037)2.38156467
151endocrine hormone secretion (GO:0060986)2.38037406
152homocysteine metabolic process (GO:0050667)2.37360063
153protein hydroxylation (GO:0018126)2.36606677
154embryonic retina morphogenesis in camera-type eye (GO:0060059)2.36368656
155positive regulation of lipid catabolic process (GO:0050996)2.35520009
156NADH metabolic process (GO:0006734)2.33817224
157muscle filament sliding (GO:0030049)2.33498032
158actin-myosin filament sliding (GO:0033275)2.33498032
159cellular response to nutrient (GO:0031670)2.33493492
160positive regulation of endothelial cell apoptotic process (GO:2000353)2.31959148
161acylglycerol catabolic process (GO:0046464)2.31142860
162neutral lipid catabolic process (GO:0046461)2.31142860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.50367353
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.92299892
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.30844893
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.10836649
5CLOCK_20551151_ChIP-Seq_293T_Human2.99897772
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.86325649
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74781143
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.52850804
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.46444212
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.34553078
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.27784184
12* RXR_22158963_ChIP-Seq_LIVER_Mouse2.21957003
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.13666430
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.01691495
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.00275610
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.98575281
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95505039
18PPARA_22158963_ChIP-Seq_LIVER_Mouse1.90423458
19* CJUN_26792858_Chip-Seq_BT549_Human1.83793025
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75844427
21* TBX20_22328084_ChIP-Seq_HEART_Mouse1.70284898
22* TBX20_22080862_ChIP-Seq_HEART_Mouse1.70284898
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.69827881
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.56329833
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53266230
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49885931
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49885931
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49781340
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.46889647
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43259149
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42914900
32SMC3_22415368_ChIP-Seq_MEFs_Mouse1.42822098
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.42512373
34* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40354552
35SA1_22415368_ChIP-Seq_MEFs_Mouse1.40200564
36* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39782395
37DROSHA_22980978_ChIP-Seq_HELA_Human1.39327258
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.39127938
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37368625
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36832656
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34352228
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34352228
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33150453
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32381614
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32308124
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30332626
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27521088
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.25786934
49* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25168433
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23692645
51* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23260533
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22426230
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.22139828
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20889882
55EZH2_22144423_ChIP-Seq_EOC_Human1.20809141
56RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19492163
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18585326
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18355065
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18330420
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16289329
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15026133
62* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12621270
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.12096563
64* TP53_23651856_ChIP-Seq_MEFs_Mouse1.12015104
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10904843
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.09017113
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07544253
68GATA1_22025678_ChIP-Seq_K562_Human1.06845636
69SOX2_20726797_ChIP-Seq_SW620_Human1.06788992
70* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05850880
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.05633005
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.04728228
73BRD4_25478319_ChIP-Seq_HGPS_Human1.03529846
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01268336
75ERG_21242973_ChIP-ChIP_JURKAT_Human0.99834978
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99307866
77TP53_22127205_ChIP-Seq_IMR90_Human0.98018563
78JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97706549
79* ISL1_27105846_Chip-Seq_CPCs_Mouse0.97676810
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95866264
81* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.95843959
82TP53_18474530_ChIP-ChIP_U2OS_Human0.95584668
83MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94892506
84P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94856073
85* LXR_22292898_ChIP-Seq_THP-1_Human0.94606389
86WT1_19549856_ChIP-ChIP_CCG9911_Human0.94568337
87NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94370624
88* CTCF_27219007_Chip-Seq_Bcells_Human0.94116847
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.93357917
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.93170611
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.92652807
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92236011
93* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91817230
94CDX2_20551321_ChIP-Seq_CACO-2_Human0.90720620
95SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90516142
96AHR_22903824_ChIP-Seq_MCF-7_Human0.90303572
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90134485
98RACK7_27058665_Chip-Seq_MCF-7_Human0.89341505
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89095420
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88594835
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88368838
102KDM2B_26808549_Chip-Seq_K562_Human0.87950541
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87660306
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87164224
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87139156
106CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87055325
107RXR_22108803_ChIP-Seq_LS180_Human0.87037761
108TP53_16413492_ChIP-PET_HCT116_Human0.86680389
109* TET1_21490601_ChIP-Seq_MESCs_Mouse0.86531984
110TCF4_18268006_ChIP-ChIP_LS174T_Human0.86521321
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86137304
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85295466
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85266393
114UBF1/2_26484160_Chip-Seq_HMECs_Human0.84711413
115BCAT_22108803_ChIP-Seq_LS180_Human0.83894016
116GBX2_23144817_ChIP-Seq_PC3_Human0.83820324
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83775914
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83597054
119STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82751733
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.82488593
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82356157
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82282649
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.81604822
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80730007
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80680636
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.80090623
127* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79793080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.50984522
2MP0005275_abnormal_skin_tensile5.39905848
3MP0005503_abnormal_tendon_morphology4.91555119
4MP0002837_dystrophic_cardiac_calcinosis4.05032193
5MP0003705_abnormal_hypodermis_morpholog3.35722663
6MP0005670_abnormal_white_adipose3.19841328
7MP0001958_emphysema2.88577753
8MP0003279_aneurysm2.59438654
9MP0000751_myopathy2.48314031
10MP0005257_abnormal_intraocular_pressure2.43122772
11MP0004272_abnormal_basement_membrane2.25709670
12MP0005666_abnormal_adipose_tissue2.18861881
13MP0000013_abnormal_adipose_tissue2.13881296
14MP0004130_abnormal_muscle_cell2.10968595
15MP0002108_abnormal_muscle_morphology1.96595869
16MP0005375_adipose_tissue_phenotype1.83557011
17MP0002060_abnormal_skin_morphology1.77385127
18MP0006054_spinal_hemorrhage1.75679764
19MP0004185_abnormal_adipocyte_glucose1.70848074
20MP0000003_abnormal_adipose_tissue1.61527898
21MP0005508_abnormal_skeleton_morphology1.60199987
22MP0004084_abnormal_cardiac_muscle1.59743107
23MP0009780_abnormal_chondrocyte_physiolo1.59298646
24MP0002295_abnormal_pulmonary_circulatio1.58795930
25MP0000749_muscle_degeneration1.56799083
26MP0003566_abnormal_cell_adhesion1.52542496
27MP0003646_muscle_fatigue1.51750099
28MP0009384_cardiac_valve_regurgitation1.50803451
29MP0005360_urolithiasis1.45646489
30MP0000750_abnormal_muscle_regeneration1.45408356
31MP0003091_abnormal_cell_migration1.42613075
32MP0005330_cardiomyopathy1.41498649
33MP0003045_fibrosis1.36950167
34MP0003252_abnormal_bile_duct1.34933441
35MP0004215_abnormal_myocardial_fiber1.34832570
36MP0010368_abnormal_lymphatic_system1.32575542
37MP0004087_abnormal_muscle_fiber1.30792232
38MP0006138_congestive_heart_failure1.30487118
39MP0004036_abnormal_muscle_relaxation1.25318577
40MP0004858_abnormal_nervous_system1.23282025
41MP0002254_reproductive_system_inflammat1.21842136
42MP0005620_abnormal_muscle_contractility1.21062023
43MP0008775_abnormal_heart_ventricle1.20593990
44MP0000049_abnormal_middle_ear1.16705548
45MP0002971_abnormal_brown_adipose1.15506377
46MP0010329_abnormal_lipoprotein_level1.15253063
47MP0000759_abnormal_skeletal_muscle1.14332595
48MP0001348_abnormal_lacrimal_gland1.12386135
49MP0002972_abnormal_cardiac_muscle1.12025937
50MP0010386_abnormal_urinary_bladder1.11927121
51MP0001299_abnormal_eye_distance/1.11385963
52MP0005369_muscle_phenotype1.10811859
53MP0001544_abnormal_cardiovascular_syste1.09965672
54MP0005385_cardiovascular_system_phenoty1.09965672
55MP0005164_abnormal_response_to1.09635346
56MP0005623_abnormal_meninges_morphology1.08837522
57MP0002139_abnormal_hepatobiliary_system1.08592169
58MP0009115_abnormal_fat_cell1.06914860
59MP0002896_abnormal_bone_mineralization1.04074232
60MP0003828_pulmonary_edema1.03548121
61MP0003191_abnormal_cellular_cholesterol1.02739404
62MP0000534_abnormal_ureter_morphology1.01473249
63MP0005023_abnormal_wound_healing1.00129459
64MP0003942_abnormal_urinary_system0.97637319
65MP0002933_joint_inflammation0.95150084
66MP0010030_abnormal_orbit_morphology0.94826159
67MP0005365_abnormal_bile_salt0.94721385
68MP0002249_abnormal_larynx_morphology0.94283470
69MP0002168_other_aberrant_phenotype0.94249929
70MP0002877_abnormal_melanocyte_morpholog0.92152759
71MP0005334_abnormal_fat_pad0.91989987
72MP0002106_abnormal_muscle_physiology0.91556956
73MP0003385_abnormal_body_wall0.89897966
74MP0003283_abnormal_digestive_organ0.89437840
75MP0001849_ear_inflammation0.87951873
76MP0000163_abnormal_cartilage_morphology0.87664967
77MP0003011_delayed_dark_adaptation0.87413445
78MP0005390_skeleton_phenotype0.86855530
79MP0010630_abnormal_cardiac_muscle0.85229559
80MP0000767_abnormal_smooth_muscle0.85097527
81MP0002876_abnormal_thyroid_physiology0.84433955
82MP0002118_abnormal_lipid_homeostasis0.84430373
83MP0000428_abnormal_craniofacial_morphol0.83273796
84MP0000747_muscle_weakness0.83012340
85MP0004145_abnormal_muscle_electrophysio0.82426794
86MP0004883_abnormal_blood_vessel0.81779998
87MP0004484_altered_response_of0.81206326
88MP0000343_altered_response_to0.81196907
89MP0002269_muscular_atrophy0.80984630
90MP0005595_abnormal_vascular_smooth0.80399362
91MP0001879_abnormal_lymphatic_vessel0.79415541
92MP0002998_abnormal_bone_remodeling0.79174330
93MP0004134_abnormal_chest_morphology0.78920729
94MP0000462_abnormal_digestive_system0.77805495
95MP0001243_abnormal_dermal_layer0.77415597
96MP0001756_abnormal_urination0.74897848
97MP0000230_abnormal_systemic_arterial0.74397692
98MP0009250_abnormal_appendicular_skeleto0.73957707
99MP0002113_abnormal_skeleton_development0.73491823
100MP0002115_abnormal_skeleton_extremities0.72796781
101MP0002970_abnormal_white_adipose0.71428953
102MP0000538_abnormal_urinary_bladder0.70966114
103MP0003115_abnormal_respiratory_system0.70584170
104MP0005058_abnormal_lysosome_morphology0.70379772
105MP0002127_abnormal_cardiovascular_syste0.70204771
106MP0001542_abnormal_bone_strength0.69713791
107MP0001661_extended_life_span0.69687868
108MP0004043_abnormal_pH_regulation0.69108419
109MP0000733_abnormal_muscle_development0.68935688
110MP0003795_abnormal_bone_structure0.68674413
111MP0001614_abnormal_blood_vessel0.68497356
112MP0005388_respiratory_system_phenotype0.68489460
113MP0002133_abnormal_respiratory_system0.68489460
114MP0009643_abnormal_urine_homeostasis0.67112672
115MP0009840_abnormal_foam_cell0.66640276
116MP0002128_abnormal_blood_circulation0.66149881
117MP0003300_gastrointestinal_ulcer0.65776545
118MP0000681_abnormal_thyroid_gland0.65579601
119MP0001175_abnormal_lung_morphology0.64937592
120MP0002078_abnormal_glucose_homeostasis0.64703463
121MP0003941_abnormal_skin_development0.64259094
122MP0005171_absent_coat_pigmentation0.63836851
123MP0002932_abnormal_joint_morphology0.62621756
124MP0005332_abnormal_amino_acid0.62331793
125MP0003950_abnormal_plasma_membrane0.61779904
126MP0000249_abnormal_blood_vessel0.61498697
127MP0001533_abnormal_skeleton_physiology0.61453787
128MP0003724_increased_susceptibility_to0.61179123
129MP0003448_altered_tumor_morphology0.60368096
130MP0005448_abnormal_energy_balance0.60266205
131MP0004510_myositis0.58954343
132MP0002116_abnormal_craniofacial_bone0.58261773
133MP0000762_abnormal_tongue_morphology0.53066162
134MP0000432_abnormal_head_morphology0.52957557
135MP0005197_abnormal_uvea_morphology0.52738492

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.15181649
2Premature rupture of membranes (HP:0001788)6.40838334
3Broad metatarsal (HP:0001783)5.26675375
4Increased connective tissue (HP:0009025)4.56341111
5Ankle contracture (HP:0006466)4.32809894
6Aortic dissection (HP:0002647)4.25875763
7Muscle fiber splitting (HP:0003555)3.97833958
8Type 1 muscle fiber predominance (HP:0003803)3.91312877
9Arterial tortuosity (HP:0005116)3.89701775
10Soft skin (HP:0000977)3.88406159
11Aortic aneurysm (HP:0004942)3.87192002
12Shallow orbits (HP:0000586)3.87051516
13Right ventricular cardiomyopathy (HP:0011663)3.77811465
14Cerebral aneurysm (HP:0004944)3.62388734
15Bladder diverticulum (HP:0000015)3.53662459
16Atrophic scars (HP:0001075)3.47264209
17Aortic regurgitation (HP:0001659)3.30078509
18Fragile skin (HP:0001030)3.23733837
19Cervical subluxation (HP:0003308)3.15729164
20Peritonitis (HP:0002586)3.12404467
21Dilatation of the ascending aorta (HP:0005111)3.11917020
22Spinal rigidity (HP:0003306)3.10476726
23Follicular hyperkeratosis (HP:0007502)3.08504020
24Increased variability in muscle fiber diameter (HP:0003557)3.08000570
25Mitral valve prolapse (HP:0001634)2.92398578
26Wrist flexion contracture (HP:0001239)2.89455143
27Vertebral compression fractures (HP:0002953)2.88151560
28Aortic valve stenosis (HP:0001650)2.84502017
29Lipoatrophy (HP:0100578)2.82590382
30Blue sclerae (HP:0000592)2.80066737
31Sudden death (HP:0001699)2.77108858
32Aneurysm (HP:0002617)2.75676420
33Ventricular tachycardia (HP:0004756)2.72651109
34Hyporeflexia of lower limbs (HP:0002600)2.69918650
35Myoglobinuria (HP:0002913)2.67436451
36Abnormality of skeletal muscle fiber size (HP:0012084)2.65357960
37Mildly elevated creatine phosphokinase (HP:0008180)2.64905664
38Hyperextensible skin (HP:0000974)2.63269961
39Coronal craniosynostosis (HP:0004440)2.62950969
40Joint stiffness (HP:0001387)2.62017049
41Round ear (HP:0100830)2.59840619
42Hypoventilation (HP:0002791)2.54435490
43Asymmetric septal hypertrophy (HP:0001670)2.47631823
44Oligomenorrhea (HP:0000876)2.46210261
45Abnormality of proline metabolism (HP:0010907)2.44767599
46Hydroxyprolinuria (HP:0003080)2.44767599
47Genu recurvatum (HP:0002816)2.43886684
48Ectopia lentis (HP:0001083)2.41106590
49Calf muscle hypertrophy (HP:0008981)2.37490617
50Thin bony cortex (HP:0002753)2.36790548
51Difficulty running (HP:0009046)2.35805128
52Exercise-induced myalgia (HP:0003738)2.35741216
53Abnormality of the calf musculature (HP:0001430)2.33125287
54Nonimmune hydrops fetalis (HP:0001790)2.33003908
55Hypoglycemic coma (HP:0001325)2.31960980
56Wormian bones (HP:0002645)2.31821671
57Mild short stature (HP:0003502)2.31122773
58Emphysema (HP:0002097)2.29659769
59Slender build (HP:0001533)2.28698329
60Abnormality of dentin (HP:0010299)2.25427948
61Abnormality of complement system (HP:0005339)2.24934686
62Striae distensae (HP:0001065)2.24455665
63Neonatal short-limb short stature (HP:0008921)2.24229869
64Complement deficiency (HP:0004431)2.22872912
65Atrial fibrillation (HP:0005110)2.21499620
66Redundant skin (HP:0001582)2.20065171
67Joint laxity (HP:0001388)2.19400537
68Vascular tortuosity (HP:0004948)2.19320086
69Abnormal delivery (HP:0001787)2.17957345
70Ketoacidosis (HP:0001993)2.17103534
71Hyperglycinuria (HP:0003108)2.16859092
72Long toe (HP:0010511)2.16338471
73Ovoid vertebral bodies (HP:0003300)2.14720750
74Acanthosis nigricans (HP:0000956)2.14637027
75Bell-shaped thorax (HP:0001591)2.14429874
76Persistence of primary teeth (HP:0006335)2.14404900
77Osteolytic defects of the hand bones (HP:0009699)2.13934106
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.13934106
79Skin nodule (HP:0200036)2.13068720
80Bowel diverticulosis (HP:0005222)2.09904509
81Rectal prolapse (HP:0002035)2.09695563
82Muscle hypertrophy of the lower extremities (HP:0008968)2.07777063
83Systemic lupus erythematosus (HP:0002725)2.06865907
84Overgrowth (HP:0001548)2.06510662
85Mitral stenosis (HP:0001718)2.06170071
86Wide anterior fontanel (HP:0000260)2.04135031
87Delayed closure of the anterior fontanelle (HP:0001476)2.03218850
88Biconcave vertebral bodies (HP:0004586)2.01890444
89Infantile muscular hypotonia (HP:0008947)2.00305662
90Exercise-induced muscle cramps (HP:0003710)1.98830976
91Primary atrial arrhythmia (HP:0001692)1.98814326
92Hip contracture (HP:0003273)1.97581496
93Generalized aminoaciduria (HP:0002909)1.93522405
94Mesomelia (HP:0003027)1.93341086
95Camptodactyly of toe (HP:0001836)1.92988965
96Turricephaly (HP:0000262)1.92730498
97Venous abnormality (HP:0002624)1.91873213
98Lymphangioma (HP:0100764)1.89938579
99Ulnar bowing (HP:0003031)1.89933477
100Supraventricular arrhythmia (HP:0005115)1.89465424
101Breech presentation (HP:0001623)1.89275291
102Delayed cranial suture closure (HP:0000270)1.89197959
103Dilated cardiomyopathy (HP:0001644)1.88154215
104Abnormality of the acetabulum (HP:0003170)1.87773571
105Ketosis (HP:0001946)1.87286496
106Abnormality of fatty-acid metabolism (HP:0004359)1.86867621
107Broad ribs (HP:0000885)1.85560783
108Gingival overgrowth (HP:0000212)1.85340701
109Venous insufficiency (HP:0005293)1.85138854
110Inguinal hernia (HP:0000023)1.83553115
111Flat cornea (HP:0007720)1.83187974
112Obstructive sleep apnea (HP:0002870)1.83007753
113Supraventricular tachycardia (HP:0004755)1.82960388
114Limited hip movement (HP:0008800)1.82480173
115Natal tooth (HP:0000695)1.81548616
116Protruding ear (HP:0000411)1.81365749
117Insulin-resistant diabetes mellitus (HP:0000831)1.81267269
118Hypoplasia of the iris (HP:0007676)1.80262601
119Spondylolisthesis (HP:0003302)1.79389539
120Bundle branch block (HP:0011710)1.78243406
121Hypoplastic ischia (HP:0003175)1.78072248
122Disproportionate tall stature (HP:0001519)1.77043767
123Deviation of the hallux (HP:0010051)1.76330494
124Pulmonary artery stenosis (HP:0004415)1.75359410
125Myotonia (HP:0002486)1.75266119
126Osteoarthritis (HP:0002758)1.75050019
127Thoracolumbar scoliosis (HP:0002944)1.74808513
128Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74588776
129Mitral regurgitation (HP:0001653)1.73843553
130Elbow flexion contracture (HP:0002987)1.73798530
131Narrow nasal bridge (HP:0000446)1.73660056
132Generalized amyotrophy (HP:0003700)1.73298752
133Tarsal synostosis (HP:0008368)1.72636591
134Coxa vara (HP:0002812)1.72236954
135Flared iliac wings (HP:0002869)1.72234348
136Limb-girdle muscle weakness (HP:0003325)1.71673460
137Ulnar deviation of the wrist (HP:0003049)1.71135769
138Abnormality of skull ossification (HP:0002703)1.70778306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.04889385
2TTN3.96829312
3SIK13.37996186
4ERN13.03996812
5KIT2.65947989
6CAMK1D2.60303110
7LATS12.58769946
8LMTK22.58044290
9RIPK12.56108534
10DDR22.49579356
11PDGFRA2.39771387
12BCKDK2.38025908
13MYLK2.37093292
14INSRR2.16756353
15PRKD32.11037288
16CAMK1G2.09926478
17TESK11.97600213
18DMPK1.94413095
19GRK11.91994068
20PHKG11.87265043
21PHKG21.87265043
22LATS21.82403141
23PDK31.81675650
24PDK41.81675650
25GRK51.80934581
26OBSCN1.80375976
27EPHB21.75691651
28PIK3CA1.71302994
29FRK1.63624538
30EPHA31.55200623
31TGFBR21.52173133
32FER1.46858633
33PKN21.46448355
34ADRBK11.43680005
35STK38L1.40939725
36MST1R1.34486060
37MAPK71.30936087
38ADRBK21.25700429
39LIMK11.23684368
40ABL21.23436191
41TIE11.23214782
42GRK71.22937665
43PDK21.11379427
44FGFR41.09527083
45PRKAA21.08827476
46PAK31.03855260
47PRKCH1.03456440
48EPHB11.02085687
49PRKD20.97166962
50PRKD10.96572880
51MAPKAPK30.96472127
52PTK60.95525936
53MET0.91128297
54JAK10.87862117
55PIK3CG0.85831352
56MAP3K30.85050543
57MAP3K70.83904190
58PTK20.83161385
59PAK20.83054199
60RPS6KC10.82866217
61RPS6KL10.82866217
62FGFR30.82338190
63PINK10.81275581
64CDC42BPA0.80927243
65MOS0.80300665
66STK380.77201295
67PDGFRB0.75330365
68MTOR0.74881260
69PRKAA10.73543628
70WNK40.73253963
71GRK60.72051035
72WNK10.70352774
73RPS6KA60.70329825
74ROCK10.68900735
75FGFR20.67852030
76MAP3K20.66414739
77MAP2K10.65684521
78PTK2B0.63730774
79MAPK40.63555929
80BMX0.59397309
81EEF2K0.58893051
82ROCK20.58056418
83AKT30.56365839
84TGFBR10.56225527
85HIPK20.56194187
86CAMK2G0.54640429
87IRAK10.54329884
88ILK0.52816298
89MAP2K30.51644432
90MARK20.49848546
91TYK20.49076856
92NEK90.48548245
93SGK30.48131000
94GSK3A0.47962433
95CAMK40.46161301
96RET0.46102645
97TBK10.45801900
98STK30.45759988
99IRAK30.45034305
100ZAK0.43809261
101PRKCE0.43319245
102FLT30.43076609
103MARK10.41671270
104CAMK10.41101550
105PAK10.39252392
106PRKG20.39201447
107NLK0.37518872
108FGFR10.37160488
109PIM20.37056051
110NEK20.36958171
111RPS6KA20.36425002
112MAPK120.36391947
113PDPK10.36347481
114MAPK110.35774961
115ARAF0.35561288
116MAPK150.35470509
117ZAP700.34953465
118TRPM70.34222208
119MAPKAPK20.34003248
120DAPK30.33976738
121ICK0.33450311
122ERBB40.32973146
123JAK20.32493629
124PAK40.31499101
125PRKACG0.31436713
126CSK0.30397828
127JAK30.29955617
128DYRK1B0.29180276
129PRKG10.28948533
130SRC0.27053319
131MAP3K60.26370343
132INSR0.26233585
133CDK60.24305011
134NTRK10.23363906
135TAOK10.23185833
136SGK20.22560743

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.03185069
2Propanoate metabolism_Homo sapiens_hsa006402.74517248
3ECM-receptor interaction_Homo sapiens_hsa045122.74486507
4PPAR signaling pathway_Homo sapiens_hsa033202.54426593
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51640955
6Fatty acid degradation_Homo sapiens_hsa000712.49421686
7Fatty acid metabolism_Homo sapiens_hsa012122.24684491
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20740733
9Protein digestion and absorption_Homo sapiens_hsa049742.18056454
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.03456352
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.91260325
12Dilated cardiomyopathy_Homo sapiens_hsa054141.86051646
13Focal adhesion_Homo sapiens_hsa045101.73741333
14Tryptophan metabolism_Homo sapiens_hsa003801.58193463
15Caffeine metabolism_Homo sapiens_hsa002321.57595010
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56046893
17Butanoate metabolism_Homo sapiens_hsa006501.52195172
18Starch and sucrose metabolism_Homo sapiens_hsa005001.49630243
19Fat digestion and absorption_Homo sapiens_hsa049751.48800334
20Fatty acid biosynthesis_Homo sapiens_hsa000611.48682855
21Pyruvate metabolism_Homo sapiens_hsa006201.46356430
22Insulin resistance_Homo sapiens_hsa049311.43823975
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.42394628
24beta-Alanine metabolism_Homo sapiens_hsa004101.35991712
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26148955
26Hedgehog signaling pathway_Homo sapiens_hsa043401.25815885
27AMPK signaling pathway_Homo sapiens_hsa041521.25241359
28Glycerolipid metabolism_Homo sapiens_hsa005611.22186057
29Carbon metabolism_Homo sapiens_hsa012001.13884670
30Lysine degradation_Homo sapiens_hsa003101.13040742
31Amoebiasis_Homo sapiens_hsa051461.10502955
32Pertussis_Homo sapiens_hsa051331.09785923
33Melanogenesis_Homo sapiens_hsa049161.08979071
34Peroxisome_Homo sapiens_hsa041461.08381811
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.06473813
36Gap junction_Homo sapiens_hsa045401.03751213
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.03492347
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03043773
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00598807
40Insulin signaling pathway_Homo sapiens_hsa049100.95805927
41Sulfur metabolism_Homo sapiens_hsa009200.94957485
42Complement and coagulation cascades_Homo sapiens_hsa046100.93899632
43Phenylalanine metabolism_Homo sapiens_hsa003600.93340069
44Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92559480
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91958917
46Axon guidance_Homo sapiens_hsa043600.91831130
47Pathways in cancer_Homo sapiens_hsa052000.91777360
48Glucagon signaling pathway_Homo sapiens_hsa049220.91090738
49Galactose metabolism_Homo sapiens_hsa000520.88292891
50Notch signaling pathway_Homo sapiens_hsa043300.87716870
51Platelet activation_Homo sapiens_hsa046110.86314014
52Oxytocin signaling pathway_Homo sapiens_hsa049210.86183060
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86110140
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85863355
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85625735
56Type II diabetes mellitus_Homo sapiens_hsa049300.84502486
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83764799
58Rap1 signaling pathway_Homo sapiens_hsa040150.83243416
59Proteoglycans in cancer_Homo sapiens_hsa052050.82622011
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.82472298
61Nitrogen metabolism_Homo sapiens_hsa009100.81502823
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80973470
63Calcium signaling pathway_Homo sapiens_hsa040200.79592150
64Arginine biosynthesis_Homo sapiens_hsa002200.78411945
65Renin-angiotensin system_Homo sapiens_hsa046140.78373613
66GnRH signaling pathway_Homo sapiens_hsa049120.76922323
67Bladder cancer_Homo sapiens_hsa052190.75860221
68Adherens junction_Homo sapiens_hsa045200.75343227
69Prostate cancer_Homo sapiens_hsa052150.75081348
70Cocaine addiction_Homo sapiens_hsa050300.74578593
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74548520
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74335013
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73795431
74Bile secretion_Homo sapiens_hsa049760.73363485
75Malaria_Homo sapiens_hsa051440.72564187
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72283532
77MicroRNAs in cancer_Homo sapiens_hsa052060.70750676
78cAMP signaling pathway_Homo sapiens_hsa040240.68930164
79Ras signaling pathway_Homo sapiens_hsa040140.67998179
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.67616446
81Tight junction_Homo sapiens_hsa045300.67108700
82Phagosome_Homo sapiens_hsa041450.66749657
83Vitamin digestion and absorption_Homo sapiens_hsa049770.65530148
84Estrogen signaling pathway_Homo sapiens_hsa049150.65517172
85ABC transporters_Homo sapiens_hsa020100.65229968
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64951395
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64878237
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64771217
89Tyrosine metabolism_Homo sapiens_hsa003500.64701638
90MAPK signaling pathway_Homo sapiens_hsa040100.63865298
91Arachidonic acid metabolism_Homo sapiens_hsa005900.62192053
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61496076
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60133896
94TNF signaling pathway_Homo sapiens_hsa046680.59659398
95Wnt signaling pathway_Homo sapiens_hsa043100.58539361
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.58348791
97Basal cell carcinoma_Homo sapiens_hsa052170.57696439
98Glioma_Homo sapiens_hsa052140.56741901
99Histidine metabolism_Homo sapiens_hsa003400.56666972
100Fatty acid elongation_Homo sapiens_hsa000620.56628732
101Arginine and proline metabolism_Homo sapiens_hsa003300.56070798
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55371429
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55197919
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55109237
105Renin secretion_Homo sapiens_hsa049240.54421175
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53631706
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53414958
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53257533
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53015485
110Cardiac muscle contraction_Homo sapiens_hsa042600.52532557
111Melanoma_Homo sapiens_hsa052180.52419711
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.52284147
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52105721
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51780374
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.50967900
116TGF-beta signaling pathway_Homo sapiens_hsa043500.50395947
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49560737
118Endocytosis_Homo sapiens_hsa041440.47446739
119Viral myocarditis_Homo sapiens_hsa054160.47345330
120Gastric acid secretion_Homo sapiens_hsa049710.46827802
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46673723
122Lysosome_Homo sapiens_hsa041420.46299043
123Small cell lung cancer_Homo sapiens_hsa052220.45995030
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45898342
125Toxoplasmosis_Homo sapiens_hsa051450.45031125
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.44985582
127Staphylococcus aureus infection_Homo sapiens_hsa051500.44133964
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.44006108
129Fructose and mannose metabolism_Homo sapiens_hsa000510.43793094
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43558179
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43418820
132mTOR signaling pathway_Homo sapiens_hsa041500.43059654
133Circadian rhythm_Homo sapiens_hsa047100.42675298
134Choline metabolism in cancer_Homo sapiens_hsa052310.42497006
135Osteoclast differentiation_Homo sapiens_hsa043800.41642312
136Other glycan degradation_Homo sapiens_hsa005110.40092857
137Thyroid hormone synthesis_Homo sapiens_hsa049180.39813132
138Insulin secretion_Homo sapiens_hsa049110.39145467
139Chronic myeloid leukemia_Homo sapiens_hsa052200.38918337
140Prion diseases_Homo sapiens_hsa050200.38321848
141Retinol metabolism_Homo sapiens_hsa008300.38168929
142Chemical carcinogenesis_Homo sapiens_hsa052040.37752032
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37135666
144Ovarian steroidogenesis_Homo sapiens_hsa049130.36524601
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36249751
146Hippo signaling pathway_Homo sapiens_hsa043900.36070081
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34836908
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34620309
149Mineral absorption_Homo sapiens_hsa049780.33639014

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