PODXL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cell differentiation involved in kidney development (GO:0035850)8.34238404
2regulation of gene silencing by RNA (GO:0060966)7.91361084
3regulation of posttranscriptional gene silencing (GO:0060147)7.91361084
4regulation of gene silencing by miRNA (GO:0060964)7.91361084
5vascular endothelial growth factor signaling pathway (GO:0038084)6.84295664
6endothelial cell chemotaxis (GO:0035767)6.20277771
7pre-miRNA processing (GO:0031054)6.11808527
8paraxial mesoderm development (GO:0048339)6.11011957
9negative regulation of axon guidance (GO:1902668)6.04701680
10regulation of axon guidance (GO:1902667)5.96466666
11coronary vasculature morphogenesis (GO:0060977)5.82031321
12establishment of integrated proviral latency (GO:0075713)5.51663791
13cell migration involved in sprouting angiogenesis (GO:0002042)5.50386511
14positive regulation of p38MAPK cascade (GO:1900745)5.39109850
15surfactant homeostasis (GO:0043129)5.38118324
16positive regulation of SMAD protein import into nucleus (GO:0060391)5.37560233
17protein complex localization (GO:0031503)5.29601830
18regulation of cell fate specification (GO:0042659)5.22021020
19heterochromatin organization (GO:0070828)5.03415241
20lymphangiogenesis (GO:0001946)5.00844952
21venous blood vessel morphogenesis (GO:0048845)4.99093445
22DNA unwinding involved in DNA replication (GO:0006268)4.87444710
23endothelium development (GO:0003158)4.81633218
24lymph vessel development (GO:0001945)4.81497490
25cell adhesion mediated by integrin (GO:0033627)4.80507941
26renal filtration (GO:0097205)4.80499177
27regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.80453647
28protein localization to endosome (GO:0036010)4.72270062
29nuclear pore complex assembly (GO:0051292)4.64449663
30regulation of histone H3-K9 methylation (GO:0051570)4.64366672
31regulation of axon extension involved in axon guidance (GO:0048841)4.59472190
32kidney mesenchyme development (GO:0072074)4.48760564
33cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.43564864
34regulation of glomerular filtration (GO:0003093)4.40786814
35vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.36851622
36protein localization to kinetochore (GO:0034501)4.29130799
37chemical homeostasis within a tissue (GO:0048875)4.27668848
38angiotensin maturation (GO:0002003)4.27426843
39activation of Rac GTPase activity (GO:0032863)4.24647990
40L-serine metabolic process (GO:0006563)4.24356161
41regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.23934778
42negative regulation of histone methylation (GO:0031061)4.15062071
43regulation of p38MAPK cascade (GO:1900744)4.13050218
44patterning of blood vessels (GO:0001569)4.09970249
45blood vessel endothelial cell migration (GO:0043534)4.09447907
46establishment of viral latency (GO:0019043)4.07929374
47metanephric mesenchyme development (GO:0072075)4.07703944
48lung vasculature development (GO:0060426)4.06154650
49regulation of gene silencing (GO:0060968)4.02816333
50nuclear pore organization (GO:0006999)4.01650142
51lung-associated mesenchyme development (GO:0060484)4.00342139
52wound healing, spreading of epidermal cells (GO:0035313)3.98181783
53cell differentiation involved in kidney development (GO:0061005)3.97830570
54mesodermal cell differentiation (GO:0048333)3.94207398
55regulation of SMAD protein import into nucleus (GO:0060390)3.92356320
56cellular protein complex localization (GO:0034629)3.91213773
57histone arginine methylation (GO:0034969)3.89170748
58negative regulation of cell fate specification (GO:0009996)3.88860880
59sprouting angiogenesis (GO:0002040)3.88374940
60regulation of endothelial cell chemotaxis (GO:2001026)3.87634893
61negative regulation of homotypic cell-cell adhesion (GO:0034111)3.86866519
62notochord development (GO:0030903)3.84019246
63axon extension involved in axon guidance (GO:0048846)3.83933271
64neuron projection extension involved in neuron projection guidance (GO:1902284)3.83933271
65retina vasculature morphogenesis in camera-type eye (GO:0061299)3.82640580
66convergent extension (GO:0060026)3.79668590
67negative regulation of axon extension involved in axon guidance (GO:0048843)3.78207557
68L-alpha-amino acid transmembrane transport (GO:1902475)3.77555185
69diaphragm development (GO:0060539)3.75400260
70negative regulation of gene silencing (GO:0060969)3.71052593
71renal system process involved in regulation of blood volume (GO:0001977)3.68047289
72protein localization to chromosome, centromeric region (GO:0071459)3.67763542
73cell fate commitment involved in formation of primary germ layer (GO:0060795)3.66765537
74planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64635970
75negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.60724291
76negative regulation of translation, ncRNA-mediated (GO:0040033)3.60724291
77regulation of translation, ncRNA-mediated (GO:0045974)3.60724291
78platelet-derived growth factor receptor signaling pathway (GO:0048008)3.50183364
79regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.48254969
80auditory receptor cell stereocilium organization (GO:0060088)3.47278878
81positive regulation of focal adhesion assembly (GO:0051894)3.46716003
82positive regulation of cell junction assembly (GO:1901890)3.46716003
83regulation of alkaline phosphatase activity (GO:0010692)3.46583836
84positive regulation of vascular permeability (GO:0043117)3.42925056
85branching involved in salivary gland morphogenesis (GO:0060445)3.40920612
86skeletal muscle organ development (GO:0060538)3.39782198
87smooth muscle tissue development (GO:0048745)3.39653065
88positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.39629930
89positive regulation of adherens junction organization (GO:1903393)3.35360860
90regulation of Rac protein signal transduction (GO:0035020)3.32288030
91regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.32268918
92regulation of chromatin silencing (GO:0031935)3.30465335
93regulation of cell fate commitment (GO:0010453)3.29505653
94establishment of apical/basal cell polarity (GO:0035089)3.27858515
95protein-DNA complex disassembly (GO:0032986)3.25741050
96nucleosome disassembly (GO:0006337)3.25741050
97negative regulation of androgen receptor signaling pathway (GO:0060766)3.25127184
98endothelial cell morphogenesis (GO:0001886)3.23147488
99pore complex assembly (GO:0046931)3.22644423
100dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.20091837
101regulation of vascular permeability (GO:0043114)3.19578126
102regulation of stem cell maintenance (GO:2000036)3.18611800
103negative regulation of cell fate commitment (GO:0010454)3.15848740
104glomerular filtration (GO:0003094)3.15271328
105endothelial cell migration (GO:0043542)3.13373394
106dopaminergic neuron differentiation (GO:0071542)3.12445892
107stress fiber assembly (GO:0043149)3.10187882
108epithelial cell-cell adhesion (GO:0090136)3.08915586
109G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.04560597
110ganglion development (GO:0061548)3.02216504
111mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.02033140
112DNA strand elongation involved in DNA replication (GO:0006271)3.01861321
113endocytic recycling (GO:0032456)3.00417120
114positive regulation of cell cycle G2/M phase transition (GO:1902751)3.00103981
115positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.00103981
116regulation of helicase activity (GO:0051095)2.99641355
117regulation of catenin import into nucleus (GO:0035412)2.98938111
118anterior/posterior axis specification, embryo (GO:0008595)2.97786992
119gap junction assembly (GO:0016264)2.97777627
120somatic stem cell division (GO:0048103)2.97656240
121regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.97370842
122establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.96223595
123protein heterotrimerization (GO:0070208)2.95888678
124positive regulation of catenin import into nucleus (GO:0035413)2.95846934
125labyrinthine layer development (GO:0060711)2.94483891
126regulation of extracellular matrix disassembly (GO:0010715)2.94279609
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93751568
128IMP biosynthetic process (GO:0006188)2.93491544
129DNA strand elongation (GO:0022616)2.93412631
130hippo signaling (GO:0035329)2.91719025
131substrate adhesion-dependent cell spreading (GO:0034446)2.91548823
132IMP metabolic process (GO:0046040)2.91230782
133mitotic sister chromatid cohesion (GO:0007064)2.90134832
134morphogenesis of an epithelial sheet (GO:0002011)2.89542495
135negative regulation of vascular permeability (GO:0043116)2.88949234
136metanephric epithelium development (GO:0072207)2.88837503
137ureteric bud development (GO:0001657)2.88716301
138substrate-dependent cell migration (GO:0006929)2.87792488
139renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.87467354
140mesenchymal to epithelial transition (GO:0060231)2.87450904
141cell surface receptor signaling pathway involved in heart development (GO:0061311)2.85990150
142regulation of translational fidelity (GO:0006450)2.85298459
143negative regulation of platelet activation (GO:0010544)2.84912935
144cardiac muscle cell proliferation (GO:0060038)2.83709954
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.83143433
146dorsal/ventral axis specification (GO:0009950)2.82413288
147mitotic metaphase plate congression (GO:0007080)2.82266418
148DNA duplex unwinding (GO:0032508)2.81756782
149myoblast fusion (GO:0007520)2.81052635
150mesonephric epithelium development (GO:0072163)2.81027822
151embryonic heart tube development (GO:0035050)2.80763577
152mesonephric tubule development (GO:0072164)2.80449274
153cell migration involved in gastrulation (GO:0042074)2.79758121
154positive regulation of axon extension (GO:0045773)2.79289510
155ATP-dependent chromatin remodeling (GO:0043044)2.76576227
156establishment or maintenance of apical/basal cell polarity (GO:0035088)2.76499517
157establishment or maintenance of bipolar cell polarity (GO:0061245)2.76499517
158mitotic chromosome condensation (GO:0007076)2.75247102
159lysine catabolic process (GO:0006554)2.75221690
160lysine metabolic process (GO:0006553)2.75221690
161positive regulation of chromosome segregation (GO:0051984)2.75181068
162semaphorin-plexin signaling pathway (GO:0071526)2.74776782
163basement membrane organization (GO:0071711)2.74143594
164RNA stabilization (GO:0043489)2.72251339
165mRNA stabilization (GO:0048255)2.72251339
166regulation of corticosteroid hormone secretion (GO:2000846)2.71134406
167regulation of cell proliferation involved in kidney development (GO:1901722)2.68617183
168neural tube development (GO:0021915)2.68458352
169DNA geometric change (GO:0032392)2.68015393
170NLS-bearing protein import into nucleus (GO:0006607)2.67590475
171chromatin assembly (GO:0031497)2.67505758
172negative regulation of chemotaxis (GO:0050922)2.67441025
173positive regulation of histone deacetylation (GO:0031065)2.67173744
174establishment or maintenance of monopolar cell polarity (GO:0061339)2.65924623
175establishment of monopolar cell polarity (GO:0061162)2.65924623
176positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.65643038
177peptidyl-arginine omega-N-methylation (GO:0035247)2.63244316
178DNA replication initiation (GO:0006270)2.63101484
179wound healing, spreading of cells (GO:0044319)2.61327648
180negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61301457
181excretion (GO:0007588)2.60757966
182adherens junction assembly (GO:0034333)2.60579020
183positive regulation of protein kinase C signaling (GO:0090037)2.58248240
184neuron remodeling (GO:0016322)2.55887168
185negative regulation of fibroblast apoptotic process (GO:2000270)2.55473531
186cellular response to hepatocyte growth factor stimulus (GO:0035729)2.55003072
187response to hepatocyte growth factor (GO:0035728)2.55003072
188nodal signaling pathway (GO:0038092)2.53419778
189outer ear morphogenesis (GO:0042473)2.52905227
190generation of neurons (GO:0048699)2.50965898
191mRNA transcription from RNA polymerase II promoter (GO:0042789)2.50894542
192lateral sprouting from an epithelium (GO:0060601)2.50211204
193regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.47388137
194* glomerular visceral epithelial cell development (GO:0072015)18.7681001
195glomerular basement membrane development (GO:0032836)18.5337530
196* glomerular epithelial cell development (GO:0072310)16.3552938
197glomerulus development (GO:0032835)12.3494118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.85503586
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.44844527
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.44021563
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.21006304
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.21006304
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.21006304
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.81796340
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.40019065
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.24341799
10CLOCK_20551151_ChIP-Seq_293T_Human3.21786781
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.00201530
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.77331357
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74417687
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64936128
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.60477857
16* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.59946211
17EZH2_22144423_ChIP-Seq_EOC_Human2.59866537
18NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.58022520
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.55690271
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55195074
21* WT1_19549856_ChIP-ChIP_CCG9911_Human2.52430365
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46871166
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37517984
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.35508245
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32745183
26* ESR1_21235772_ChIP-Seq_MCF-7_Human2.32073316
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.30969098
28* WT1_25993318_ChIP-Seq_PODOCYTE_Human2.29262490
29GATA2_21666600_ChIP-Seq_HMVEC_Human2.27003804
30* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26399098
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25636722
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17857988
33* ESR2_21235772_ChIP-Seq_MCF-7_Human2.17542450
34SOX2_16153702_ChIP-ChIP_HESCs_Human2.14293639
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12053187
36* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.08868444
37POU5F1_16153702_ChIP-ChIP_HESCs_Human2.07563064
38* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03666574
39SOX2_18555785_ChIP-Seq_MESCs_Mouse2.03432883
40* NANOG_16153702_ChIP-ChIP_HESCs_Human2.03260206
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.98108241
42AR_21909140_ChIP-Seq_LNCAP_Human1.95414209
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93522272
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91261291
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90206326
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89686828
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83634467
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.81177718
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80622715
50* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80501115
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78130865
52AHR_22903824_ChIP-Seq_MCF-7_Human1.73177975
53* ERG_21242973_ChIP-ChIP_JURKAT_Human1.72544427
54* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.71459005
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.69579117
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.68535468
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.65604536
58* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65259753
59* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65259753
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64786695
61* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64159806
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63722398
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.61753057
64* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60787146
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.60743048
66* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60110900
67KDM2B_26808549_Chip-Seq_K562_Human1.58830761
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58307491
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58179617
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57845332
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.57584527
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54862989
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54529223
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53846960
75* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53344768
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52897319
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52414055
78* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52369584
79* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50669465
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50367500
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.48852494
82* NANOG_21062744_ChIP-ChIP_HESCs_Human1.48630808
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48473439
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48317870
85* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.47022608
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46845379
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46692187
88* EED_16625203_ChIP-ChIP_MESCs_Mouse1.46549657
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43507918
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43198371
91POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.42848136
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42791478
93* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.41397567
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40344893
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39650298
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38458958
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38194361
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.37966560
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.37966560
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.37529700
101E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37021725
102* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.33184233
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.33046387
104* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32246912
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30824664
106* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29942003
107* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27718354
108* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.27706217
109* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27652430
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.27563445
111* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26542103
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26242347
113TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25306023
114* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.25212900
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25195910
116* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25040553
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24477329
118TBX3_20139965_ChIP-Seq_MESCs_Mouse1.24371404
119* SMAD3_21741376_ChIP-Seq_HESCs_Human1.23898429
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23026045
121ELK3_25401928_ChIP-Seq_HUVEC_Human1.22940638
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22439568
123ESR1_20079471_ChIP-ChIP_T-47D_Human1.21678437
124CJUN_26792858_Chip-Seq_BT549_Human1.20818353
125* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20795879
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20748147
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19956330
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19935607
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19634157
130* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18762441
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17644928
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17102519
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17092039
134* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16909975
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16615267
136XRN2_22483619_ChIP-Seq_HELA_Human1.16153544
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16102076
138* KAP1_27257070_Chip-Seq_ESCs_Mouse1.16058602
139EZH2_27294783_Chip-Seq_ESCs_Mouse1.15874132
140SOX17_20123909_ChIP-Seq_XEN_Mouse1.14932090
141* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.14569622
142* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14273854
143RXR_22108803_ChIP-Seq_LS180_Human1.14100309
144YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13783724
145JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13761322
146* BRD4_25478319_ChIP-Seq_HGPS_Human1.13069893
147RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12264314
148* NANOG_16518401_ChIP-PET_MESCs_Mouse1.11790392
149NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11108946
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10416640
151ZNF263_19887448_ChIP-Seq_K562_Human1.10113800
152* SOX2_20726797_ChIP-Seq_SW620_Human1.10040569
153CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09670403
154NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09398311
155EGR1_19374776_ChIP-ChIP_THP-1_Human1.08266536
156FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07525043
157CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07427921
158RNF2_27304074_Chip-Seq_ESCs_Mouse1.07258197
159* ISL1_27105846_Chip-Seq_CPCs_Mouse1.07051284
160CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05943671
161MYC_22102868_ChIP-Seq_BL_Human1.05450920
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04712020
163* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04566829
164* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04259066
165* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03210573
166ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03097647
167FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02736023
168SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02343725
169PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01946669
170THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01861562
171CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01855203
172PIAS1_25552417_ChIP-Seq_VCAP_Human1.01800638
173GATA1_19941826_ChIP-Seq_K562_Human1.00802943
174RING1B_27294783_Chip-Seq_NPCs_Mouse1.00698478
175ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00389429
176FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00228145
177* TP53_20018659_ChIP-ChIP_R1E_Mouse0.99962229
178P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99787803
179KDM2B_26808549_Chip-Seq_DND41_Human0.99553240
180SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97494432
181* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97373286
182* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95698185
183HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95647964
184* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94316245
185CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94219095
186TP53_16413492_ChIP-PET_HCT116_Human0.93331024
187EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91854931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane5.94082839
2MP0005623_abnormal_meninges_morphology5.80227615
3MP0010368_abnormal_lymphatic_system5.65565783
4MP0002254_reproductive_system_inflammat5.24765964
5MP0001879_abnormal_lymphatic_vessel4.71756087
6MP0004084_abnormal_cardiac_muscle4.51993365
7MP0000537_abnormal_urethra_morphology3.49741846
8MP0004036_abnormal_muscle_relaxation2.89330351
9MP0009672_abnormal_birth_weight2.88271329
10MP0004957_abnormal_blastocyst_morpholog2.85321332
11MP0001661_extended_life_span2.83868237
12MP0003693_abnormal_embryo_hatching2.71657723
13MP0005167_abnormal_blood-brain_barrier2.61628578
14MP0003942_abnormal_urinary_system2.56369481
15MP0003890_abnormal_embryonic-extraembry2.55025938
16MP0003111_abnormal_nucleus_morphology2.41247061
17MP0000534_abnormal_ureter_morphology2.37473544
18MP0010030_abnormal_orbit_morphology2.21805170
19MP0008932_abnormal_embryonic_tissue2.14077607
20MP0001730_embryonic_growth_arrest2.10282362
21MP0010352_gastrointestinal_tract_polyps2.06125411
22MP0008057_abnormal_DNA_replication2.03277545
23MP0009643_abnormal_urine_homeostasis2.00794563
24MP0001849_ear_inflammation1.99518093
25* MP0002136_abnormal_kidney_physiology1.99031490
26MP0003567_abnormal_fetal_cardiomyocyte1.95958263
27* MP0002135_abnormal_kidney_morphology1.89901296
28MP0001293_anophthalmia1.89534000
29MP0003136_yellow_coat_color1.88795303
30MP0010094_abnormal_chromosome_stability1.88634353
31MP0001299_abnormal_eye_distance/1.86879967
32MP0005332_abnormal_amino_acid1.85733209
33MP0003941_abnormal_skin_development1.85521305
34* MP0000230_abnormal_systemic_arterial1.83748362
35MP0002084_abnormal_developmental_patter1.83310874
36MP0001672_abnormal_embryogenesis/_devel1.83002067
37MP0005380_embryogenesis_phenotype1.83002067
38MP0002085_abnormal_embryonic_tissue1.81023354
39MP0004133_heterotaxia1.75992746
40MP0006138_congestive_heart_failure1.73681613
41MP0003566_abnormal_cell_adhesion1.73064598
42MP0003984_embryonic_growth_retardation1.71464521
43MP0009384_cardiac_valve_regurgitation1.71071812
44MP0003705_abnormal_hypodermis_morpholog1.70433853
45MP0005187_abnormal_penis_morphology1.70092062
46MP0001756_abnormal_urination1.69708247
47MP0002128_abnormal_blood_circulation1.66604777
48MP0003091_abnormal_cell_migration1.65999055
49MP0000428_abnormal_craniofacial_morphol1.65657769
50MP0002088_abnormal_embryonic_growth/wei1.65575689
51MP0003077_abnormal_cell_cycle1.65327174
52MP0000013_abnormal_adipose_tissue1.63239395
53MP0000767_abnormal_smooth_muscle1.58813946
54MP0003283_abnormal_digestive_organ1.58524486
55MP0003279_aneurysm1.58168452
56MP0009703_decreased_birth_body1.56551612
57MP0008775_abnormal_heart_ventricle1.48355529
58MP0003718_maternal_effect1.46305220
59MP0002295_abnormal_pulmonary_circulatio1.42891485
60MP0005385_cardiovascular_system_phenoty1.40749690
61MP0001544_abnormal_cardiovascular_syste1.40749690
62MP0001697_abnormal_embryo_size1.40204259
63MP0005257_abnormal_intraocular_pressure1.39374071
64MP0000566_synostosis1.39024843
65* MP0001614_abnormal_blood_vessel1.38647316
66MP0004233_abnormal_muscle_weight1.37191585
67MP0005165_increased_susceptibility_to1.35747540
68MP0000350_abnormal_cell_proliferation1.35138890
69MP0004197_abnormal_fetal_growth/weight/1.34782654
70MP0002080_prenatal_lethality1.34706724
71MP0008877_abnormal_DNA_methylation1.34331366
72MP0001915_intracranial_hemorrhage1.33731120
73MP0000049_abnormal_middle_ear1.33064489
74MP0003828_pulmonary_edema1.32348017
75MP0002796_impaired_skin_barrier1.30457306
76MP0002925_abnormal_cardiovascular_devel1.30254020
77MP0005197_abnormal_uvea_morphology1.29550285
78MP0005367_renal/urinary_system_phenotyp1.28514226
79MP0000516_abnormal_urinary_system1.28514226
80MP0004185_abnormal_adipocyte_glucose1.26880922
81MP0000432_abnormal_head_morphology1.26240074
82MP0004264_abnormal_extraembryonic_tissu1.25266660
83MP0002111_abnormal_tail_morphology1.24769372
84MP0003861_abnormal_nervous_system1.20719967
85MP0008961_abnormal_basal_metabolism1.19805206
86MP0004484_altered_response_of1.18160014
87MP0003115_abnormal_respiratory_system1.17834196
88MP0004858_abnormal_nervous_system1.16672712
89MP0005503_abnormal_tendon_morphology1.16641952
90MP0002972_abnormal_cardiac_muscle1.16632422
91MP0010630_abnormal_cardiac_muscle1.14778544
92MP0002233_abnormal_nose_morphology1.09946558
93* MP0001784_abnormal_fluid_regulation1.08446663
94MP0000762_abnormal_tongue_morphology1.07061452
95MP0002092_abnormal_eye_morphology1.07052405
96MP0008058_abnormal_DNA_repair1.06694880
97MP0003878_abnormal_ear_physiology1.03634430
98MP0005377_hearing/vestibular/ear_phenot1.03634430
99MP0000003_abnormal_adipose_tissue1.01331884
100MP0003935_abnormal_craniofacial_develop1.01152108
101MP0003300_gastrointestinal_ulcer0.99516548
102MP0003943_abnormal_hepatobiliary_system0.99223248
103MP0003937_abnormal_limbs/digits/tail_de0.96776721
104MP0003303_peritoneal_inflammation0.96727615
105MP0000747_muscle_weakness0.96649474
106MP0006292_abnormal_olfactory_placode0.96622469
107MP0005076_abnormal_cell_differentiation0.95934461
108MP0005620_abnormal_muscle_contractility0.94952505
109MP0005193_abnormal_anterior_eye0.94926698
110MP0002089_abnormal_postnatal_growth/wei0.93471674
111MP0005595_abnormal_vascular_smooth0.90258662
112MP0009697_abnormal_copulation0.87963918
113MP0002877_abnormal_melanocyte_morpholog0.87836188
114MP0000678_abnormal_parathyroid_gland0.86457155
115MP0002127_abnormal_cardiovascular_syste0.86183112
116MP0000266_abnormal_heart_morphology0.83508938
117MP0005501_abnormal_skin_physiology0.82690079
118MP0001188_hyperpigmentation0.81949211
119MP0000751_myopathy0.81105901
120MP0003385_abnormal_body_wall0.78479914
121MP0002697_abnormal_eye_size0.77883910
122MP0003755_abnormal_palate_morphology0.76664275
123MP0002090_abnormal_vision0.74894937
124MP0004085_abnormal_heartbeat0.74727012
125MP0000163_abnormal_cartilage_morphology0.74596104
126* MP0002081_perinatal_lethality0.74510792
127MP0006072_abnormal_retinal_apoptosis0.73596188
128MP0001177_atelectasis0.72729703
129MP0008007_abnormal_cellular_replicative0.72490467
130MP0000579_abnormal_nail_morphology0.70847742
131MP0004130_abnormal_muscle_cell0.70774202
132MP0005375_adipose_tissue_phenotype0.70723090
133MP0002116_abnormal_craniofacial_bone0.70611354
134MP0000462_abnormal_digestive_system0.70290405
135MP0008770_decreased_survivor_rate0.69408526
136MP0004087_abnormal_muscle_fiber0.69268861
137MP0003121_genomic_imprinting0.68485735
138MP0005330_cardiomyopathy0.68131997
139MP0002896_abnormal_bone_mineralization0.67121865
140MP0010234_abnormal_vibrissa_follicle0.66119277
141MP0001175_abnormal_lung_morphology0.65948902
142MP0000313_abnormal_cell_death0.65676230
143MP0002932_abnormal_joint_morphology0.65185086
144MP0002269_muscular_atrophy0.64665554
145MP0001286_abnormal_eye_development0.63787188
146MP0002086_abnormal_extraembryonic_tissu0.60137328
147MP0009053_abnormal_anal_canal0.59611086
148MP0005023_abnormal_wound_healing0.59476127
149MP0001346_abnormal_lacrimal_gland0.59238977
150MP0009278_abnormal_bone_marrow0.59072287
151MP0000343_altered_response_to0.58803778
152MP0004215_abnormal_myocardial_fiber0.58485510
153MP0003123_paternal_imprinting0.56506912
154MP0003119_abnormal_digestive_system0.56004242
155MP0001324_abnormal_eye_pigmentation0.55954153
156MP0005508_abnormal_skeleton_morphology0.53531711
157MP0010386_abnormal_urinary_bladder0.52799509
158MP0010307_abnormal_tumor_latency0.52684758
159MP0005666_abnormal_adipose_tissue0.51694170
160MP0002282_abnormal_trachea_morphology0.51687997
161MP0004859_abnormal_synaptic_plasticity0.51283794
162MP0009780_abnormal_chondrocyte_physiolo0.51190871
163MP0002113_abnormal_skeleton_development0.51026094
164MP0002138_abnormal_hepatobiliary_system0.50910566

Predicted human phenotypes

RankGene SetZ-score
1Glomerulosclerosis (HP:0000096)9.31527511
2Hypoalbuminemia (HP:0003073)9.14455038
3Abnormal albumin level (HP:0012116)9.14455038
4Nephritis (HP:0000123)6.95407748
5Glomerulonephritis (HP:0000099)6.68100465
6Stage 5 chronic kidney disease (HP:0003774)6.51157499
7Nephrotic syndrome (HP:0000100)4.91194071
8Tubular atrophy (HP:0000092)4.63967248
9Hepatoblastoma (HP:0002884)4.22724966
10Hypoproteinemia (HP:0003075)4.07909311
11Proteinuria (HP:0000093)4.06162856
12Lymphangioma (HP:0100764)4.01704274
13Corneal erosion (HP:0200020)3.94269003
14Metaphyseal dysplasia (HP:0100255)3.87107488
15Rapidly progressive (HP:0003678)3.86600677
16Spastic diplegia (HP:0001264)3.86252693
17Nonprogressive disorder (HP:0003680)3.81944933
18Neonatal respiratory distress (HP:0002643)3.68080981
19Hematuria (HP:0000790)3.59945120
20Potter facies (HP:0002009)3.39541288
21Facial shape deformation (HP:0011334)3.39541288
22Polycythemia (HP:0001901)3.37913909
23Hematochezia (HP:0002573)3.34759000
24Septo-optic dysplasia (HP:0100842)3.27467660
25Cortical dysplasia (HP:0002539)3.21968127
26Selective tooth agenesis (HP:0001592)3.19511235
27Polar cataract (HP:0010696)3.12028887
28Deep venous thrombosis (HP:0002625)3.08835201
29Visceral angiomatosis (HP:0100761)3.00513538
30Nephroblastoma (Wilms tumor) (HP:0002667)2.99103462
31Skull defect (HP:0001362)2.98192383
32Metaphyseal cupping (HP:0003021)2.95994774
33Tubulointerstitial fibrosis (HP:0005576)2.92295528
34Bronchomalacia (HP:0002780)2.91442818
35Aplasia involving bones of the upper limbs (HP:0009823)2.85638461
36Aplasia of the phalanges of the hand (HP:0009802)2.85638461
37Aplasia involving bones of the extremities (HP:0009825)2.85638461
38Embryonal renal neoplasm (HP:0011794)2.84660867
39Hemangiomatosis (HP:0007461)2.78997873
40Colon cancer (HP:0003003)2.71142957
41Bilateral microphthalmos (HP:0007633)2.69202997
42Myelomeningocele (HP:0002475)2.65642838
43Short hallux (HP:0010109)2.63197428
44Maternal diabetes (HP:0009800)2.58775005
45Broad thumb (HP:0011304)2.55203935
46Arnold-Chiari malformation (HP:0002308)2.49118490
47Pterygium (HP:0001059)2.45703211
48Absent eyebrow (HP:0002223)2.45630668
49Stenosis of the external auditory canal (HP:0000402)2.45440543
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.44076019
51Abnormality of the labia minora (HP:0012880)2.42604121
52Partial duplication of thumb phalanx (HP:0009944)2.42535652
53Aortic aneurysm (HP:0004942)2.41724740
54Cutaneous syndactyly (HP:0012725)2.39637543
55Persistence of primary teeth (HP:0006335)2.37063612
56Increased nuchal translucency (HP:0010880)2.36095825
57Venous insufficiency (HP:0005293)2.35476385
58Overriding aorta (HP:0002623)2.35394199
59Abnormal tarsal ossification (HP:0008369)2.34870586
60Coronal craniosynostosis (HP:0004440)2.34788563
61Gastrointestinal carcinoma (HP:0002672)2.34176478
62Malignant gastrointestinal tract tumors (HP:0006749)2.34176478
63Ridged nail (HP:0001807)2.31244480
64Aplasia of the musculature (HP:0100854)2.27966542
65Spontaneous hematomas (HP:0007420)2.27655893
66Anomalous pulmonary venous return (HP:0010772)2.25425974
67Aplasia/Hypoplasia of the sternum (HP:0006714)2.25100279
68Down-sloping shoulders (HP:0200021)2.24389786
69Chronic bronchitis (HP:0004469)2.22296540
70Hypoparathyroidism (HP:0000829)2.17636815
71Preaxial foot polydactyly (HP:0001841)2.17211519
72Hypophosphatemia (HP:0002148)2.16860604
73Abnormality of the pulmonary veins (HP:0011718)2.15985515
74Absent eyelashes (HP:0000561)2.14560353
75Hip contracture (HP:0003273)2.13903579
76Shawl scrotum (HP:0000049)2.13123806
77Retinal atrophy (HP:0001105)2.11913661
78Abnormality of the septum pellucidum (HP:0007375)2.11420389
79Abnormality of the lacrimal duct (HP:0011481)2.10407975
80Premature rupture of membranes (HP:0001788)2.10392599
81Abnormal lung lobation (HP:0002101)2.10268317
82High anterior hairline (HP:0009890)2.07869952
83Ankle contracture (HP:0006466)2.07210162
84Cutaneous finger syndactyly (HP:0010554)2.06825967
85Omphalocele (HP:0001539)2.05180234
86Abnormality of the fingertips (HP:0001211)2.04829377
87Trigonocephaly (HP:0000243)2.04272303
88Facial cleft (HP:0002006)2.02804573
89Germ cell neoplasia (HP:0100728)2.01545446
90Partial duplication of the phalanx of hand (HP:0009999)2.01387421
91Duplication of thumb phalanx (HP:0009942)2.01011966
92Cerebral hemorrhage (HP:0001342)2.00824391
93Esophageal varix (HP:0002040)2.00308177
94Mesangial abnormality (HP:0001966)12.0939857
95Focal segmental glomerulosclerosis (HP:0000097)11.9939305
96Aneurysm (HP:0002617)1.99973064
97Cavernous hemangioma (HP:0001048)1.98956242
98Broad phalanges of the hand (HP:0009768)1.98252572
99Broad finger (HP:0001500)1.96943226
100Abnormality of the salivary glands (HP:0010286)1.96073787
101Hyperacusis (HP:0010780)1.95770865
102Absent septum pellucidum (HP:0001331)1.95624830
103Absent radius (HP:0003974)1.94070365
104Abnormality of the middle phalanges of the toes (HP:0010183)1.93662066
105Breast aplasia (HP:0100783)1.92151163
106Broad long bones (HP:0005622)1.91176397
107Venous abnormality (HP:0002624)1.90131973
108Humeroradial synostosis (HP:0003041)1.88762280
109Synostosis involving the elbow (HP:0003938)1.88762280
110Hypoglycemic seizures (HP:0002173)1.88540099
111Vertebral clefting (HP:0008428)1.87924028
112Shoulder girdle muscle weakness (HP:0003547)1.87432913
113Rectovaginal fistula (HP:0000143)1.87321671
114Rectal fistula (HP:0100590)1.87321671
115Fused cervical vertebrae (HP:0002949)1.86298120
116Esophageal atresia (HP:0002032)1.86290162
117Vaginal fistula (HP:0004320)1.86157627
118Aplasia/Hypoplasia of the breasts (HP:0010311)1.85917175
119Absent toe (HP:0010760)1.85045306
120Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85031130
121Concave nail (HP:0001598)1.84477459
122Cerebral aneurysm (HP:0004944)1.84435320
123Generalized hypotonia (HP:0001290)1.84313177
124Ependymoma (HP:0002888)1.84073202
125Short humerus (HP:0005792)1.83468380
126Hypoplasia of the iris (HP:0007676)1.82397150
127Choanal stenosis (HP:0000452)1.80184277
128Bifid tongue (HP:0010297)1.79971441
129Lower limb amyotrophy (HP:0007210)1.79288024
130Increased circulating renin level (HP:0000848)1.78986392
131Interstitial pulmonary disease (HP:0006530)1.78871509
132Absent forearm bone (HP:0003953)1.78771165
133Aplasia involving forearm bones (HP:0009822)1.78771165
134Hypoplastic left heart (HP:0004383)1.78084093
135Deviation of the thumb (HP:0009603)1.78008253
136Chondrocalcinosis (HP:0000934)1.77153894
137Nephrocalcinosis (HP:0000121)1.76984684
138Ulnar bowing (HP:0003031)1.76725159
139Intestinal fistula (HP:0100819)1.76279514
140Abnormality of the nasolacrimal system (HP:0000614)1.74970495
141Aplasia/hypoplasia of the humerus (HP:0006507)1.74377427
142Abnormal foot bone ossification (HP:0010675)1.74337478
143Knee flexion contracture (HP:0006380)1.74172920
144Broad metatarsal (HP:0001783)1.74148709
145Broad phalanx (HP:0006009)1.73706392
146Abnormality of the peritoneum (HP:0002585)1.73529539
147Vertebral arch anomaly (HP:0008438)1.73326644
148Exostoses (HP:0100777)1.72857695
149Uterine neoplasm (HP:0010784)1.72515204
150Renal duplication (HP:0000075)1.72080755
151Abnormality of the nasal mucosa (HP:0000433)1.71295267
152Abnormality of abdominal situs (HP:0011620)1.71049778
153Abdominal situs inversus (HP:0003363)1.71049778
154Back pain (HP:0003418)1.71035412
155Uterine leiomyosarcoma (HP:0002891)1.70288307
156Leiomyosarcoma (HP:0100243)1.70288307
157Bicornuate uterus (HP:0000813)1.70281114
158Multiple enchondromatosis (HP:0005701)1.68759424
159Embryonal neoplasm (HP:0002898)1.66238773
160Wide nose (HP:0000445)1.65809705
161Testicular neoplasm (HP:0010788)1.65730063
162Rectal prolapse (HP:0002035)1.65111305
163Abnormal number of incisors (HP:0011064)1.64978077
164Pseudobulbar signs (HP:0002200)1.64932330
165Delayed epiphyseal ossification (HP:0002663)1.64558414
166Exercise-induced muscle cramps (HP:0003710)1.64188874
167Hyporeflexia of lower limbs (HP:0002600)1.64128281
168Chromosomal breakage induced by crosslinking agents (HP:0003221)1.63683225
169Biliary tract neoplasm (HP:0100574)1.62811019
170Muscle fiber splitting (HP:0003555)1.61305463
171Abnormality of Sharpey fibers (HP:0100685)1.61072323
172Hypokalemic alkalosis (HP:0001949)1.60757021
173Hydroxyprolinuria (HP:0003080)1.58869918
174Abnormality of proline metabolism (HP:0010907)1.58869918
175Limited hip movement (HP:0008800)1.58292090
176Seborrheic dermatitis (HP:0001051)1.55709344
177Difficulty running (HP:0009046)1.53706601
178Tubulointerstitial abnormality (HP:0001969)1.52106776
179Conjunctival telangiectasia (HP:0000524)1.51193970
180Hypertensive crisis (HP:0100735)1.50923995
181Autoimmune thrombocytopenia (HP:0001973)1.50649684
182Hyperthyroidism (HP:0000836)1.47185660
183Advanced eruption of teeth (HP:0006288)1.46973387
184Hypercalciuria (HP:0002150)1.43153881
185Absent phalangeal crease (HP:0006109)1.41342199
186Midline defect of the nose (HP:0004122)1.41157565
187Exotropia (HP:0000577)1.39896576
188Shallow orbits (HP:0000586)1.38898632
189Abnormality of calcium-phosphate metabolism (HP:0100530)1.37838075
190Aqueductal stenosis (HP:0002410)1.36342466
191Arterial tortuosity (HP:0005116)1.35068190
192Vascular calcification (HP:0004934)1.34084394
193Turricephaly (HP:0000262)1.32739031
194Right ventricular cardiomyopathy (HP:0011663)1.32427469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.87537537
2EPHB25.77279944
3KDR4.72632855
4TGFBR24.19207638
5MYLK3.51151530
6PAK43.45851505
7CDC73.41441964
8TSSK63.08400995
9MAP3K103.05218940
10TTK2.93678266
11TGFBR12.91720241
12WNK42.78731003
13SMG12.76309135
14OXSR12.70731900
15TAF12.54702745
16SRPK12.43599467
17VRK22.41483432
18EEF2K2.28085398
19PDGFRA2.23127972
20STK392.07803293
21MKNK12.05552641
22TRIB31.89136995
23LATS11.83197379
24BUB11.76972810
25MKNK21.76196905
26PLK31.75312763
27TNIK1.72554591
28MAP3K91.69072535
29ERBB41.52202573
30PLK41.47934732
31RIPK11.47420137
32EPHB11.44220682
33CAMK2B1.41027948
34FGFR41.38342635
35FER1.34224161
36PAK21.28816794
37PNCK1.28758839
38NTRK11.25723860
39LRRK21.23290724
40PTK61.18079334
41ROCK11.15337011
42NEK21.14646166
43ALK1.11469559
44TTN1.11463423
45PASK1.07149924
46KIT1.06789672
47PAK31.05763112
48MAP3K71.03683419
49MST41.03384301
50STK241.02631748
51BRD41.01437160
52CHEK20.98027121
53STK100.97521080
54DYRK20.96027693
55PLK10.95802185
56WEE10.94355601
57PDK20.93040336
58PDGFRB0.92259082
59DYRK30.92080614
60GSK3A0.88085692
61PBK0.86951382
62AKT30.86817926
63LATS20.85998484
64RPS6KB20.81171851
65ERN10.78746135
66PRKCH0.78724072
67CDK70.77034045
68CHEK10.77003759
69MAP2K10.76548504
70FGFR20.73731385
71ABL20.73475380
72DMPK0.72457099
73PTK2B0.72187565
74MAP3K80.71085396
75PTK20.70258740
76PRKD10.69918465
77ZAK0.69750097
78ATR0.69392324
79ATM0.68393280
80MAPK150.67802435
81ICK0.67682197
82AURKB0.67357722
83GRK10.66382095
84CAMK1G0.66277015
85CDK40.64868312
86PKN20.61591476
87SIK10.60687731
88PDPK10.59895179
89CDK190.59084381
90MAP2K30.58565236
91CSNK1G10.58402510
92NEK10.58195137
93FGFR10.58192910
94CDK60.57420349
95FGFR30.56896339
96MTOR0.55328926
97JAK10.55272013
98CDK10.55206622
99PRKD30.54918907
100PRKG20.54890790
101MAPK120.54835283
102CDK20.54772362
103STK40.53412315
104BRSK20.53260684
105MAPK90.52301932
106SRC0.52097947
107VRK10.50912792
108PRKDC0.50747480
109FLT30.49986743
110CSNK1E0.49568820
111BMX0.49553700
112NLK0.48002853
113TYK20.46272394
114CDK150.45570084
115WNK10.45501248
116DAPK10.45316291
117CDK11A0.44918855
118AURKA0.44492378
119CAMK1D0.44319379
120CDK180.44001298
121NEK90.42790682
122TYRO30.42787517
123PRKCE0.42498864
124JAK20.42417585
125SCYL20.42273478
126IGF1R0.40901576
127RET0.40785873
128BRAF0.40408885
129EIF2AK20.39964196
130EGFR0.39597752
131BCR0.38832472
132MAPK100.38523560
133YES10.38304359
134AKT20.38247060
135CDK120.36214428
136GSK3B0.34238426
137NME10.34223780
138ROCK20.33877845
139PRKD20.32568158
140RPS6KA10.32558923
141FYN0.32226480
142ADRBK10.31783146
143CASK0.31069463
144KSR20.30714422
145WNK30.30429371
146RPS6KA40.30132034
147ARAF0.29743242
148PHKG10.28839124
149PHKG20.28839124
150MAP3K20.28785737
151EPHA20.28136494
152MARK20.27527184
153CAMK40.27022848
154MET0.26462256
155MAP2K20.25511086
156PRKACB0.25296269
157ZAP700.23891712
158MAPK70.23855745
159ABL10.22564192
160PDK10.22206684
161INSR0.21972008
162MAP3K30.21590484
163STK30.21582790
164STK38L0.20129272
165CDK140.19997528

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.77985801
2Renin-angiotensin system_Homo sapiens_hsa046143.59699813
3DNA replication_Homo sapiens_hsa030303.29121625
4Small cell lung cancer_Homo sapiens_hsa052223.20060432
5Focal adhesion_Homo sapiens_hsa045103.11952064
6Axon guidance_Homo sapiens_hsa043602.77104899
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.75040214
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.74491112
9Amoebiasis_Homo sapiens_hsa051462.74190851
10Mismatch repair_Homo sapiens_hsa034302.64825815
11Protein digestion and absorption_Homo sapiens_hsa049742.51471107
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43497315
13Dilated cardiomyopathy_Homo sapiens_hsa054142.34380712
14Spliceosome_Homo sapiens_hsa030402.24201806
15Cell cycle_Homo sapiens_hsa041102.21324937
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.20135880
17Non-homologous end-joining_Homo sapiens_hsa034502.12858435
18RNA transport_Homo sapiens_hsa030132.11607788
19mRNA surveillance pathway_Homo sapiens_hsa030152.09647934
20Basal cell carcinoma_Homo sapiens_hsa052172.07653036
21Thyroid cancer_Homo sapiens_hsa052162.00681160
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96565082
23Biosynthesis of amino acids_Homo sapiens_hsa012301.94846075
24Selenocompound metabolism_Homo sapiens_hsa004501.94217208
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.94181612
26Adherens junction_Homo sapiens_hsa045201.85539213
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84600152
28Base excision repair_Homo sapiens_hsa034101.81965411
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71554680
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66845134
31Proteoglycans in cancer_Homo sapiens_hsa052051.59923022
32Renal cell carcinoma_Homo sapiens_hsa052111.50361742
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.46826082
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.45415074
35Rap1 signaling pathway_Homo sapiens_hsa040151.45346356
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43447382
37Tight junction_Homo sapiens_hsa045301.41434996
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40787246
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40049122
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.33075803
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31036120
42One carbon pool by folate_Homo sapiens_hsa006701.29123063
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23879566
44Dorso-ventral axis formation_Homo sapiens_hsa043201.21973516
45Hippo signaling pathway_Homo sapiens_hsa043901.21923284
46Nucleotide excision repair_Homo sapiens_hsa034201.20289646
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19768639
48VEGF signaling pathway_Homo sapiens_hsa043701.19082821
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16657966
50Bladder cancer_Homo sapiens_hsa052191.14922115
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14775188
52Platelet activation_Homo sapiens_hsa046111.14573702
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13552310
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.12501221
55Hedgehog signaling pathway_Homo sapiens_hsa043401.11292210
56Renin secretion_Homo sapiens_hsa049241.11055017
57Pathways in cancer_Homo sapiens_hsa052001.09143169
58Colorectal cancer_Homo sapiens_hsa052101.07887378
59N-Glycan biosynthesis_Homo sapiens_hsa005101.05837604
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02714497
61Carbon metabolism_Homo sapiens_hsa012001.02504238
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02347532
63Vitamin B6 metabolism_Homo sapiens_hsa007501.02066372
64Pancreatic cancer_Homo sapiens_hsa052121.01777639
65Lysine degradation_Homo sapiens_hsa003101.00027569
66Gap junction_Homo sapiens_hsa045400.99914386
67Pentose phosphate pathway_Homo sapiens_hsa000300.93872583
68Gastric acid secretion_Homo sapiens_hsa049710.93653399
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92844607
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92528577
71Viral myocarditis_Homo sapiens_hsa054160.92379021
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91082888
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90898125
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89869353
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89518675
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89184765
77Oocyte meiosis_Homo sapiens_hsa041140.87382193
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.86865129
79Basal transcription factors_Homo sapiens_hsa030220.86667539
80Galactose metabolism_Homo sapiens_hsa000520.86452000
81mTOR signaling pathway_Homo sapiens_hsa041500.86107085
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81921580
83Endocytosis_Homo sapiens_hsa041440.79746234
84Pyruvate metabolism_Homo sapiens_hsa006200.79653384
85Ras signaling pathway_Homo sapiens_hsa040140.78672120
86RNA degradation_Homo sapiens_hsa030180.76919301
87Nitrogen metabolism_Homo sapiens_hsa009100.76689758
88Complement and coagulation cascades_Homo sapiens_hsa046100.75547890
89Notch signaling pathway_Homo sapiens_hsa043300.72413238
90MicroRNAs in cancer_Homo sapiens_hsa052060.71849230
91p53 signaling pathway_Homo sapiens_hsa041150.71250196
92Homologous recombination_Homo sapiens_hsa034400.70457047
93Thyroid hormone synthesis_Homo sapiens_hsa049180.69918861
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.69262012
95Glioma_Homo sapiens_hsa052140.69177679
96RNA polymerase_Homo sapiens_hsa030200.68330461
97Bile secretion_Homo sapiens_hsa049760.66904525
98cAMP signaling pathway_Homo sapiens_hsa040240.66077393
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65360013
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64903718
101Estrogen signaling pathway_Homo sapiens_hsa049150.64119370
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62353747
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62330765
104Prostate cancer_Homo sapiens_hsa052150.61921442
105Oxytocin signaling pathway_Homo sapiens_hsa049210.59847940
106Insulin resistance_Homo sapiens_hsa049310.59675568
107HIF-1 signaling pathway_Homo sapiens_hsa040660.58887912
108Arginine and proline metabolism_Homo sapiens_hsa003300.58777223
109Folate biosynthesis_Homo sapiens_hsa007900.58686022
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56737757
111Steroid biosynthesis_Homo sapiens_hsa001000.56603717
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56532300
113Arginine biosynthesis_Homo sapiens_hsa002200.55809981
114Chronic myeloid leukemia_Homo sapiens_hsa052200.54664923
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54229748
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52708207
117Pyrimidine metabolism_Homo sapiens_hsa002400.52658805
118Fanconi anemia pathway_Homo sapiens_hsa034600.51647424
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51494045
120TGF-beta signaling pathway_Homo sapiens_hsa043500.50745460
121Toxoplasmosis_Homo sapiens_hsa051450.49562029
122Wnt signaling pathway_Homo sapiens_hsa043100.49514397
123Vitamin digestion and absorption_Homo sapiens_hsa049770.48130810
124Endometrial cancer_Homo sapiens_hsa052130.47583908
125Salivary secretion_Homo sapiens_hsa049700.46869417
126Glucagon signaling pathway_Homo sapiens_hsa049220.45583215
127Insulin signaling pathway_Homo sapiens_hsa049100.45438423
128Purine metabolism_Homo sapiens_hsa002300.42100766
129Non-small cell lung cancer_Homo sapiens_hsa052230.40517334
130AMPK signaling pathway_Homo sapiens_hsa041520.39543003
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38165250
132Melanoma_Homo sapiens_hsa052180.37862575
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.37468646
134Melanogenesis_Homo sapiens_hsa049160.36766526
135Insulin secretion_Homo sapiens_hsa049110.36497080
136ErbB signaling pathway_Homo sapiens_hsa040120.36346070
137Fatty acid degradation_Homo sapiens_hsa000710.35789857
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.35458881
139Salmonella infection_Homo sapiens_hsa051320.34822332
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33705621
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33311281
142Long-term potentiation_Homo sapiens_hsa047200.32538539
143Choline metabolism in cancer_Homo sapiens_hsa052310.32029047
144MAPK signaling pathway_Homo sapiens_hsa040100.31676287
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31235182
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30622811
147Circadian entrainment_Homo sapiens_hsa047130.29530319
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28898343
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.28254986
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27965208
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27694506
152Shigellosis_Homo sapiens_hsa051310.27620619
153GnRH signaling pathway_Homo sapiens_hsa049120.24928261
154Inositol phosphate metabolism_Homo sapiens_hsa005620.23847756
155Cholinergic synapse_Homo sapiens_hsa047250.23687734
156FoxO signaling pathway_Homo sapiens_hsa040680.23455258

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