POF1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called 'POF1' and 'POF2' have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)9.24422512
2water homeostasis (GO:0030104)7.67655616
3keratinocyte differentiation (GO:0030216)7.45384994
4keratinocyte proliferation (GO:0043616)6.97302260
5hemidesmosome assembly (GO:0031581)6.80711929
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.68675461
7molting cycle (GO:0042303)6.64587180
8hair cycle (GO:0042633)6.64587180
9peptide cross-linking (GO:0018149)6.44267939
10epidermal cell differentiation (GO:0009913)6.27037631
11angiotensin maturation (GO:0002003)5.90416902
12regulation of transforming growth factor beta1 production (GO:0032908)5.80373923
13detection of bacterium (GO:0016045)5.66814897
14sphingoid metabolic process (GO:0046519)5.63683779
15intermediate filament organization (GO:0045109)5.44225809
16epidermis development (GO:0008544)5.38439244
17regulation of cell proliferation involved in kidney development (GO:1901722)5.26191634
18sphingosine metabolic process (GO:0006670)5.06546444
19intestinal absorption (GO:0050892)5.00065859
20regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.96787152
21skin morphogenesis (GO:0043589)4.93387561
22positive regulation of glomerulus development (GO:0090193)4.90612262
23detection of other organism (GO:0098543)4.89176558
24positive regulation of interleukin-8 secretion (GO:2000484)4.88993652
25regulation of ruffle assembly (GO:1900027)4.71015987
26diol metabolic process (GO:0034311)4.67328445
27regulation of phospholipase A2 activity (GO:0032429)4.67059318
28regulation of bile acid biosynthetic process (GO:0070857)4.66919358
29cellular glucuronidation (GO:0052695)4.47709061
30surfactant homeostasis (GO:0043129)4.39495292
31regulation of guanylate cyclase activity (GO:0031282)4.39444723
32chemical homeostasis within a tissue (GO:0048875)4.37104583
33regulation of cholesterol homeostasis (GO:2000188)4.34784790
34long-chain fatty acid biosynthetic process (GO:0042759)4.34409628
35keratinocyte development (GO:0003334)4.26311880
36flavonoid metabolic process (GO:0009812)4.24888419
37glucuronate metabolic process (GO:0019585)4.24523516
38uronic acid metabolic process (GO:0006063)4.24523516
39negative regulation of keratinocyte proliferation (GO:0010839)4.17007021
40fatty acid elongation (GO:0030497)4.10244250
41bile acid and bile salt transport (GO:0015721)4.07251066
42ectoderm development (GO:0007398)4.06096684
43epoxygenase P450 pathway (GO:0019373)4.03307078
44glucosamine-containing compound catabolic process (GO:1901072)4.02633472
45interferon-gamma secretion (GO:0072643)3.97392580
46antimicrobial humoral response (GO:0019730)3.93551445
47phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.88642897
48G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.84013457
49regulation of interleukin-8 secretion (GO:2000482)3.81812156
50viral transcription (GO:0019083)3.67675920
51regulation of chemokine secretion (GO:0090196)3.64514942
52renal system process involved in regulation of blood volume (GO:0001977)3.63390569
53negative regulation of cell fate specification (GO:0009996)3.59325260
54maintenance of gastrointestinal epithelium (GO:0030277)3.55775991
55phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.54596739
56sulfate transmembrane transport (GO:1902358)3.54020779
57intermediate filament cytoskeleton organization (GO:0045104)3.48732361
58O-glycan processing (GO:0016266)3.45983956
59lipoprotein transport (GO:0042953)3.45607631
60regulation of systemic arterial blood pressure by hormone (GO:0001990)3.45524417
61regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.45524417
62endocrine process (GO:0050886)3.45524417
63phospholipid scrambling (GO:0017121)3.43923577
64NADH metabolic process (GO:0006734)3.43581356
65antibacterial humoral response (GO:0019731)3.43330797
66auditory receptor cell differentiation (GO:0042491)3.43081276
67translational termination (GO:0006415)3.43038405
68regulation of glomerulus development (GO:0090192)3.42260924
69phospholipid efflux (GO:0033700)3.42048933
70intermediate filament-based process (GO:0045103)3.41675059
71negative regulation of cell fate commitment (GO:0010454)3.41058062
72atrioventricular valve morphogenesis (GO:0003181)3.41056952
73regulation of keratinocyte differentiation (GO:0045616)3.39642414
74phosphatidylcholine acyl-chain remodeling (GO:0036151)3.37080967
75gap junction assembly (GO:0016264)3.35402039
76positive regulation of guanylate cyclase activity (GO:0031284)3.34285070
77regulation of natural killer cell differentiation (GO:0032823)3.24904661
78fat-soluble vitamin biosynthetic process (GO:0042362)3.24866839
79urea cycle (GO:0000050)3.22939300
80positive regulation of cholesterol efflux (GO:0010875)3.22581938
81ribosomal small subunit biogenesis (GO:0042274)3.18734296
82intestinal epithelial cell development (GO:0060576)3.14242954
83regulation of cellular extravasation (GO:0002691)3.11696141
84regulation of vitamin metabolic process (GO:0030656)3.10817302
85virion attachment to host cell (GO:0019062)3.07798575
86adhesion of symbiont to host cell (GO:0044650)3.07798575
87planar cell polarity pathway involved in neural tube closure (GO:0090179)3.07214031
88drug metabolic process (GO:0017144)3.07156468
89regulation of systemic arterial blood pressure (GO:0003073)3.05808806
90positive regulation of epidermis development (GO:0045684)3.04923333
91urea metabolic process (GO:0019627)3.03926441
92digestion (GO:0007586)3.02195231
93phosphatidylserine metabolic process (GO:0006658)3.00328089
94transcytosis (GO:0045056)3.00012618
95lipoxygenase pathway (GO:0019372)2.99612543
96linoleic acid metabolic process (GO:0043651)2.97936910
97gland morphogenesis (GO:0022612)2.96518122
98negative regulation of interferon-gamma production (GO:0032689)2.95696958
99hormone catabolic process (GO:0042447)2.95533724
100sphingomyelin metabolic process (GO:0006684)2.92708811
101negative regulation of stress fiber assembly (GO:0051497)2.91104968
102receptor guanylyl cyclase signaling pathway (GO:0007168)2.89757006
103positive regulation of sterol transport (GO:0032373)2.89518590
104positive regulation of cholesterol transport (GO:0032376)2.89518590
105regulation of cardioblast differentiation (GO:0051890)2.88446226
106transepithelial transport (GO:0070633)2.86389903
107sulfate transport (GO:0008272)2.85636108
108eyelid development in camera-type eye (GO:0061029)2.84804222
109regulation of glomerular filtration (GO:0003093)2.81310091
110very long-chain fatty acid metabolic process (GO:0000038)2.80924855
111positive regulation of epidermal cell differentiation (GO:0045606)2.79499594
112viral life cycle (GO:0019058)2.78386016
113cyclooxygenase pathway (GO:0019371)2.78335954
114phosphatidylinositol acyl-chain remodeling (GO:0036149)2.77963179
115long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.77743144
116alditol phosphate metabolic process (GO:0052646)2.77537666
117drug transmembrane transport (GO:0006855)2.76900518
118glomerular filtration (GO:0003094)2.76728798
119primary alcohol catabolic process (GO:0034310)2.75087390
120negative regulation of T cell mediated immunity (GO:0002710)2.73563744
121nitrogen cycle metabolic process (GO:0071941)2.72736095
122regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.72539963
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71294521
124hair cell differentiation (GO:0035315)2.70658543
125fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.69082301
126positive regulation of pseudopodium assembly (GO:0031274)2.68115322
127positive regulation of glycoprotein biosynthetic process (GO:0010560)2.66900798
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66704988
129epithelium development (GO:0060429)2.66270742
130digestive system process (GO:0022600)2.65455783
131protein targeting to ER (GO:0045047)2.63769977
132ethanol metabolic process (GO:0006067)2.63070316
133epithelial cell-cell adhesion (GO:0090136)2.62240996
134skin development (GO:0043588)2.61343106
135translational elongation (GO:0006414)2.61325263
136cellular protein complex disassembly (GO:0043624)2.60546777
137cotranslational protein targeting to membrane (GO:0006613)2.60106076
138establishment of tissue polarity (GO:0007164)2.59621371
139establishment of planar polarity (GO:0001736)2.59621371
140positive regulation of chemokine secretion (GO:0090197)2.59433896
141heart valve morphogenesis (GO:0003179)2.59422792
142ventricular cardiac muscle cell action potential (GO:0086005)2.59409519
143cardiac right ventricle morphogenesis (GO:0003215)2.59120056
144regulation of hypersensitivity (GO:0002883)2.58900635
145establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58442385
146positive regulation of hair cycle (GO:0042635)2.58140850
147positive regulation of hair follicle development (GO:0051798)2.58140850
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.57687433
149positive regulation of glycoprotein metabolic process (GO:1903020)2.57616978
150regulation of keratinocyte proliferation (GO:0010837)2.57289241
151phosphatidylserine acyl-chain remodeling (GO:0036150)2.57142060
152trophectodermal cell differentiation (GO:0001829)2.56750826
153primary alcohol metabolic process (GO:0034308)2.56605276
154positive regulation of transforming growth factor beta production (GO:0071636)2.56384733
155renal filtration (GO:0097205)2.56246050
156regulation of cGMP biosynthetic process (GO:0030826)2.56048843
157calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.53442717
158establishment of skin barrier (GO:0061436)15.2356535
159desmosome organization (GO:0002934)14.3025647
160regulation of water loss via skin (GO:0033561)13.5795184
161keratinization (GO:0031424)11.0994324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.54331083
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.03654955
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.97839536
4P63_26484246_Chip-Seq_KERATINOCYTES_Human2.90208411
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.75964773
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.56839990
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.24281037
8FOXO3_23340844_ChIP-Seq_DLD1_Human2.13551111
9SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.11585852
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.11585852
11TP63_17297297_ChIP-ChIP_HaCaT_Human14.2263373
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98331554
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90171775
14ZNF263_19887448_ChIP-Seq_K562_Human1.87874840
15TCF4_18268006_ChIP-ChIP_LS174T_Human1.79189625
16* SOX2_20726797_ChIP-Seq_SW620_Human1.75791576
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74762966
18LXR_22158963_ChIP-Seq_LIVER_Mouse1.61597888
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60938031
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59549403
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57088683
22TP63_23658742_ChIP-Seq_EP156T_Human1.56373438
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50668885
24GATA4_25053715_ChIP-Seq_YYC3_Human1.49140666
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48553649
26TP53_18474530_ChIP-ChIP_U2OS_Human1.48067084
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.47980620
28CDX2_22108803_ChIP-Seq_LS180_Human1.45040787
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.43417529
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36844660
31CJUN_26792858_Chip-Seq_BT549_Human1.35561971
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34447153
33* KLF5_25053715_ChIP-Seq_YYC3_Human1.33662939
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.33389835
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30072507
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29029872
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25841511
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25688757
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23077325
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22684557
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22663319
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22177907
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21757139
44AR_21572438_ChIP-Seq_LNCaP_Human1.20171091
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.18221922
46RXR_22108803_ChIP-Seq_LS180_Human1.14847534
47TP63_22573176_ChIP-Seq_HFKS_Human1.12700298
48GATA6_25053715_ChIP-Seq_YYC3_Human1.10671011
49BCAT_22108803_ChIP-Seq_LS180_Human1.10336371
50VDR_22108803_ChIP-Seq_LS180_Human1.09683052
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09587950
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09126761
53GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07913882
54AHR_22903824_ChIP-Seq_MCF-7_Human1.05926416
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.04890688
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04498001
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03776853
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01636734
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.01416321
60FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01100084
61RACK7_27058665_Chip-Seq_MCF-7_Human1.00683525
62ATF3_27146783_Chip-Seq_COLON_Human0.99444901
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98405663
64CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97438715
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96148309
66UBF1/2_26484160_Chip-Seq_HMECs_Human0.95624400
67* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95040004
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94841120
69GATA1_22025678_ChIP-Seq_K562_Human0.93410541
70GATA2_19941826_ChIP-Seq_K562_Human0.93269017
71CEBPB_22108803_ChIP-Seq_LS180_Human0.93221112
72NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92727554
73TP53_20018659_ChIP-ChIP_R1E_Mouse0.92685243
74TP53_16413492_ChIP-PET_HCT116_Human0.92333809
75* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92275598
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90453826
77GATA6_21074721_ChIP-Seq_CACO-2_Human0.89382962
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89046712
79CLOCK_20551151_ChIP-Seq_293T_Human0.87058157
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86052633
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85610633
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84118999
83SUZ12_27294783_Chip-Seq_ESCs_Mouse0.83991180
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83027208
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.82239696
86EED_16625203_ChIP-ChIP_MESCs_Mouse0.82190816
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81637090
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80874028
89TCF4_22108803_ChIP-Seq_LS180_Human0.80428448
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78550993
91AR_21909140_ChIP-Seq_LNCAP_Human0.77321092
92BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76734454
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75558801
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.74772002
95HNF4A_19822575_ChIP-Seq_HepG2_Human0.74203050
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.73869245
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73556515
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72504479
99JARID2_20075857_ChIP-Seq_MESCs_Mouse0.70532140
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.70475933
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70437397
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.70305476
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.70185037
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.69907454
105GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.69889274
106EGR1_19032775_ChIP-ChIP_M12_Human0.69145850
107CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.69070910
108EZH2_27304074_Chip-Seq_ESCs_Mouse0.68904827
109RBPJ_21746931_ChIP-Seq_IB4_Human0.68667440
110EZH2_27294783_Chip-Seq_ESCs_Mouse0.68122283
111CTCF_27219007_Chip-Seq_Bcells_Human0.67027652
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.66670360
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.65540108
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.65081818
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63727674
116RNF2_27304074_Chip-Seq_ESCs_Mouse0.63583322
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.63346572
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63096622
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.63006817
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62969657
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62969657
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.62623288
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.62293414
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.62212425
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.61643690
126STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.61614050
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.59418161
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.59004457
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58857705
130P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.58822429
131HNFA_21074721_ChIP-Seq_CACO-2_Human0.58718307
132PPARA_22158963_ChIP-Seq_LIVER_Mouse0.58687585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.91426666
2MP0010234_abnormal_vibrissa_follicle6.87311921
3MP0005275_abnormal_skin_tensile5.73352301
4MP0003941_abnormal_skin_development5.31177685
5MP0005501_abnormal_skin_physiology4.80789840
6MP0000579_abnormal_nail_morphology3.81445594
7MP0004381_abnormal_hair_follicle3.53488757
8MP0005360_urolithiasis3.45322823
9MP0005451_abnormal_body_composition3.44754626
10MP0010678_abnormal_skin_adnexa3.36631557
11MP0002060_abnormal_skin_morphology3.31675403
12MP0002254_reproductive_system_inflammat3.30948208
13MP0001216_abnormal_epidermal_layer3.23241002
14MP0002098_abnormal_vibrissa_morphology3.16229745
15MP0010771_integument_phenotype2.92967529
16MP0004947_skin_inflammation2.84031236
17MP0000383_abnormal_hair_follicle2.82305441
18MP0000647_abnormal_sebaceous_gland2.58690304
19MP0003453_abnormal_keratinocyte_physiol2.56881657
20MP0005085_abnormal_gallbladder_physiolo2.56776995
21MP0000377_abnormal_hair_follicle2.44297911
22MP0002139_abnormal_hepatobiliary_system2.37318178
23MP0005365_abnormal_bile_salt2.27059753
24MP0000427_abnormal_hair_cycle2.21913841
25MP0003183_abnormal_peptide_metabolism2.21844078
26MP0002009_preneoplasia2.06594735
27MP0000467_abnormal_esophagus_morphology2.05957826
28MP0009379_abnormal_foot_pigmentation1.88772981
29MP0003705_abnormal_hypodermis_morpholog1.83612668
30MP0000762_abnormal_tongue_morphology1.76887048
31MP0001346_abnormal_lacrimal_gland1.76685524
32MP0003191_abnormal_cellular_cholesterol1.71295199
33MP0000566_synostosis1.70908300
34MP0009931_abnormal_skin_appearance1.65460580
35MP0004043_abnormal_pH_regulation1.64443001
36MP0004147_increased_porphyrin_level1.60951591
37MP0001664_abnormal_digestion1.59535135
38MP0003866_abnormal_defecation1.56107096
39MP0001191_abnormal_skin_condition1.53197625
40MP0004185_abnormal_adipocyte_glucose1.46229618
41MP0003566_abnormal_cell_adhesion1.43719352
42MP0004782_abnormal_surfactant_physiolog1.43699584
43MP0000367_abnormal_coat/_hair1.31491034
44MP0003868_abnormal_feces_composition1.26266610
45MP0001243_abnormal_dermal_layer1.25659685
46MP0000477_abnormal_intestine_morphology1.16493782
47MP0001765_abnormal_ion_homeostasis1.16302844
48MP0003252_abnormal_bile_duct1.08806595
49MP0000015_abnormal_ear_pigmentation1.03101839
50MP0005174_abnormal_tail_pigmentation1.01511254
51MP0009840_abnormal_foam_cell1.00101919
52MP0000465_gastrointestinal_hemorrhage0.98088295
53MP0000490_abnormal_crypts_of0.97122470
54MP0008004_abnormal_stomach_pH0.96076233
55MP0010352_gastrointestinal_tract_polyps0.91181880
56MP0009643_abnormal_urine_homeostasis0.89401845
57MP0001340_abnormal_eyelid_morphology0.88972274
58MP0009780_abnormal_chondrocyte_physiolo0.88507806
59MP0001851_eye_inflammation0.87714277
60MP0010329_abnormal_lipoprotein_level0.87169796
61MP0000537_abnormal_urethra_morphology0.86975565
62MP0005670_abnormal_white_adipose0.85937569
63MP0004264_abnormal_extraembryonic_tissu0.85714123
64MP0005636_abnormal_mineral_homeostasis0.83156840
65MP0002138_abnormal_hepatobiliary_system0.81118038
66MP0002136_abnormal_kidney_physiology0.77408334
67MP0003950_abnormal_plasma_membrane0.75549423
68MP0001756_abnormal_urination0.72644751
69MP0001663_abnormal_digestive_system0.70179583
70MP0005381_digestive/alimentary_phenotyp0.69594268
71MP0009384_cardiac_valve_regurgitation0.69094422
72MP0003315_abnormal_perineum_morphology0.67106561
73MP0002166_altered_tumor_susceptibility0.66753129
74MP0001485_abnormal_pinna_reflex0.66589431
75MP0005166_decreased_susceptibility_to0.66230775
76MP0002249_abnormal_larynx_morphology0.66193120
77MP0000516_abnormal_urinary_system0.64687850
78MP0005367_renal/urinary_system_phenotyp0.64687850
79MP0010030_abnormal_orbit_morphology0.63828392
80MP0002877_abnormal_melanocyte_morpholog0.63807400
81MP0002234_abnormal_pharynx_morphology0.63256907
82MP0002006_tumorigenesis0.62053033
83MP0005332_abnormal_amino_acid0.59902440
84MP0005023_abnormal_wound_healing0.59656446
85MP0009053_abnormal_anal_canal0.59306692
86MP0002177_abnormal_outer_ear0.58397705
87MP0001873_stomach_inflammation0.58026977
88MP0000627_abnormal_mammary_gland0.57860498
89MP0001784_abnormal_fluid_regulation0.57520355
90MP0000538_abnormal_urinary_bladder0.56890604
91MP0002277_abnormal_respiratory_mucosa0.56383603
92MP0002118_abnormal_lipid_homeostasis0.56224050
93MP0008875_abnormal_xenobiotic_pharmacok0.55189242
94MP0002876_abnormal_thyroid_physiology0.53979933
95MP0001764_abnormal_homeostasis0.53075334
96MP0003878_abnormal_ear_physiology0.52080101
97MP0005377_hearing/vestibular/ear_phenot0.52080101
98MP0000470_abnormal_stomach_morphology0.51359281
99MP0003136_yellow_coat_color0.51211528
100MP0000678_abnormal_parathyroid_gland0.50076205
101MP0006054_spinal_hemorrhage0.49627793
102MP0005076_abnormal_cell_differentiation0.49263241
103MP0001849_ear_inflammation0.48589017
104MP0001666_abnormal_nutrient_absorption0.48150990
105MP0002282_abnormal_trachea_morphology0.48071285
106MP0002095_abnormal_skin_pigmentation0.47643270
107MP0004019_abnormal_vitamin_homeostasis0.47498483
108MP0001501_abnormal_sleep_pattern0.45780012
109MP0003755_abnormal_palate_morphology0.45759304
110MP0009115_abnormal_fat_cell0.45136537
111MP0005187_abnormal_penis_morphology0.44372413
112MP0004272_abnormal_basement_membrane0.44270450
113MP0000230_abnormal_systemic_arterial0.44069234
114MP0003011_delayed_dark_adaptation0.43919680
115MP0009333_abnormal_splenocyte_physiolog0.43482551
116MP0001177_atelectasis0.42769911
117MP0005508_abnormal_skeleton_morphology0.41645529
118MP0000609_abnormal_liver_physiology0.41424444
119MP0002971_abnormal_brown_adipose0.40238970
120MP0000613_abnormal_salivary_gland0.38012005
121MP0005666_abnormal_adipose_tissue0.35291116
122MP0008961_abnormal_basal_metabolism0.35024793
123MP0005409_darkened_coat_color0.33622297
124MP0005248_abnormal_Harderian_gland0.33380872
125MP0010155_abnormal_intestine_physiology0.32876874
126MP0002111_abnormal_tail_morphology0.32012651
127MP0003300_gastrointestinal_ulcer0.31191413
128MP0000432_abnormal_head_morphology0.30780509
129MP0002233_abnormal_nose_morphology0.29861528
130MP0003638_abnormal_response/metabolism_0.28468625
131MP0003385_abnormal_body_wall0.28352618
132MP0005075_abnormal_melanosome_morpholog0.28177916
133MP0009250_abnormal_appendicular_skeleto0.26506075
134MP0002896_abnormal_bone_mineralization0.26236136
135MP0005375_adipose_tissue_phenotype0.25906423
136MP0002133_abnormal_respiratory_system0.22587511
137MP0005388_respiratory_system_phenotype0.22587511
138MP0003828_pulmonary_edema0.21683647
139MP0002090_abnormal_vision0.20511832
140MP0001188_hyperpigmentation0.20178184
141MP0003763_abnormal_thymus_physiology0.19400163
142MP0005647_abnormal_sex_gland0.19372914
143MP0000462_abnormal_digestive_system0.19332894

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.34445663
2Congenital ichthyosiform erythroderma (HP:0007431)7.81058081
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.16544335
4Hypotrichosis (HP:0001006)6.96769380
5Abnormality of nail color (HP:0100643)6.87062605
6Woolly hair (HP:0002224)6.73526440
7Right ventricular cardiomyopathy (HP:0011663)6.53695607
8Onycholysis (HP:0001806)6.06099235
9Plantar hyperkeratosis (HP:0007556)6.02084481
10Palmoplantar hyperkeratosis (HP:0000972)5.55225619
11Fragile nails (HP:0001808)5.32978419
12Erythroderma (HP:0001019)5.28473570
13Palmar hyperkeratosis (HP:0010765)5.24418582
14Erythema (HP:0010783)5.23829247
15Parakeratosis (HP:0001036)5.23314918
16Hyperactive renin-angiotensin system (HP:0000841)5.17876673
17Lip pit (HP:0100267)5.10786829
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.75922083
19Pili torti (HP:0003777)4.38635716
20Malnutrition (HP:0004395)4.33853347
21Gangrene (HP:0100758)4.29429143
22Ectropion (HP:0000656)4.18487718
23Milia (HP:0001056)4.02568955
24Abnormal blistering of the skin (HP:0008066)3.89006050
25Corneal erosion (HP:0200020)3.80425430
26Sparse scalp hair (HP:0002209)3.77404323
27Curly hair (HP:0002212)3.76468980
28Hyporeflexia of lower limbs (HP:0002600)3.74605652
29Natal tooth (HP:0000695)3.70427574
30Nail dystrophy (HP:0008404)3.57885967
31Decreased circulating renin level (HP:0003351)3.54571432
32Pruritus (HP:0000989)3.53873753
33Hypohidrosis (HP:0000966)3.44366736
34Thick nail (HP:0001805)3.39979537
35Sparse eyelashes (HP:0000653)3.35181746
36Ileus (HP:0002595)3.31237004
37Acanthosis nigricans (HP:0000956)3.30267092
38Conjunctival hamartoma (HP:0100780)3.30115799
39Advanced eruption of teeth (HP:0006288)3.25096718
40Palmoplantar keratoderma (HP:0000982)3.23197868
41Hydroxyprolinuria (HP:0003080)3.19112400
42Abnormality of proline metabolism (HP:0010907)3.19112400
43Abnormality of renin-angiotensin system (HP:0000847)3.15737568
44Chronic diarrhea (HP:0002028)3.15383091
45Abnormality of the axillary hair (HP:0100134)3.10965203
46Abnormality of secondary sexual hair (HP:0009888)3.10965203
47Distal lower limb muscle weakness (HP:0009053)3.08091548
48Ventricular tachycardia (HP:0004756)3.00085270
49Fat malabsorption (HP:0002630)2.93490470
50Acanthocytosis (HP:0001927)2.91648851
51Dehydration (HP:0001944)2.87809724
52Metabolic alkalosis (HP:0200114)2.87756021
53Abnormality of chloride homeostasis (HP:0011422)2.85396433
54Congenital, generalized hypertrichosis (HP:0004540)2.80644304
55Brittle hair (HP:0002299)2.80219406
56Abnormality of monocarboxylic acid metabolism (HP:0010996)2.71623092
57Alopecia of scalp (HP:0002293)2.67691394
58Eczematoid dermatitis (HP:0000976)2.67298392
59Abnormal hair laboratory examination (HP:0003328)2.64910800
60Atrophic scars (HP:0001075)2.59692280
61Oral leukoplakia (HP:0002745)2.59088428
62Popliteal pterygium (HP:0009756)2.53872973
63Areflexia of lower limbs (HP:0002522)2.49680712
64Lack of skin elasticity (HP:0100679)2.48141851
65Flat acetabular roof (HP:0003180)2.47784080
66Dry skin (HP:0000958)2.44083844
67Hyperaldosteronism (HP:0000859)2.43467807
68Concave nail (HP:0001598)2.43300694
69Villous atrophy (HP:0011473)2.42404427
70Abnormality of small intestinal villus morphology (HP:0011472)2.42404427
71Ridged nail (HP:0001807)2.38727288
72Abnormality of the vitamin B12 metabolism (HP:0004341)2.38602805
73Abnormality of the gastric mucosa (HP:0004295)2.36352868
74Alkalosis (HP:0001948)2.34796557
75Hypergammaglobulinemia (HP:0010702)2.33800592
76Intrahepatic cholestasis (HP:0001406)2.31899160
77Abdominal distention (HP:0003270)2.25168024
78Abnormality of vitamin B metabolism (HP:0004340)2.21659699
79Hyperkalemia (HP:0002153)2.21638953
80Ventricular fibrillation (HP:0001663)2.21081563
81Abnormality of the salivary glands (HP:0010286)2.20194516
82Hypoplastic labia majora (HP:0000059)2.17755893
83Widely patent fontanelles and sutures (HP:0004492)2.16490040
84Aplasia cutis congenita (HP:0001057)2.12850470
85Conjugated hyperbilirubinemia (HP:0002908)2.12808756
86Congenital sensorineural hearing impairment (HP:0008527)2.08728823
87Abnormal hemoglobin (HP:0011902)2.08079609
88Abnormality of sodium homeostasis (HP:0010931)2.04846894
89Abnormality of the dental root (HP:0006486)2.03290810
90Taurodontia (HP:0000679)2.03290810
91Abnormality of permanent molar morphology (HP:0011071)2.03290810
92Malignant hyperthermia (HP:0002047)2.01834813
93Absent eyelashes (HP:0000561)2.01186262
94Abnormality of vitamin metabolism (HP:0100508)2.00389328
95Neonatal short-limb short stature (HP:0008921)2.00318121
96Pustule (HP:0200039)1.97750313
97Hypobetalipoproteinemia (HP:0003563)1.96292946
98Abnormality of the labia majora (HP:0012881)1.95886033
99Septate vagina (HP:0001153)1.95790893
100Blepharitis (HP:0000498)1.95344998
101Thin bony cortex (HP:0002753)1.94996572
102Abnormality of cells of the erythroid lineage (HP:0012130)1.94247123
103Abnormal biliary tract morphology (HP:0012440)1.92150994
104Anhidrosis (HP:0000970)1.91488423
105Reticulocytopenia (HP:0001896)1.89738688
106Abnormality of molar (HP:0011077)1.89260639
107Abnormality of molar morphology (HP:0011070)1.89260639
108Hamartoma of the eye (HP:0010568)1.88980149
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.87738083
110Follicular hyperkeratosis (HP:0007502)1.87006249
111Abnormality of the dental pulp (HP:0006479)1.84228475
112Neonatal death (HP:0003811)1.82072607
113Pterygium (HP:0001059)1.80352057
114Pigmentary retinal degeneration (HP:0001146)1.78092948
115Oligodontia (HP:0000677)1.77943024
116Xerostomia (HP:0000217)1.77096948
117Sepsis (HP:0100806)1.76675976
118Hyperhidrosis (HP:0000975)1.76306838
119Dry hair (HP:0011359)1.76136815
120Severe Myopia (HP:0011003)1.75711074
121Stenosis of the external auditory canal (HP:0000402)1.74791761
122Hyponatremia (HP:0002902)1.74418192
123Tetraparesis (HP:0002273)1.73970651
124Fragile skin (HP:0001030)1.73521563
125Focal segmental glomerulosclerosis (HP:0000097)1.73308022
126Hypoplasia of dental enamel (HP:0006297)1.71671131
127Abnormality of the neuromuscular junction (HP:0003398)1.71648856
128Fatigable weakness (HP:0003473)1.71648856
129Abnormality of potassium homeostasis (HP:0011042)1.71425264
130Corneal dystrophy (HP:0001131)1.67861697
131Skin ulcer (HP:0200042)1.67068754
132Down-sloping shoulders (HP:0200021)1.65799842
133Hypodontia (HP:0000668)1.64802104
134Laryngomalacia (HP:0001601)1.64238890
135Increased connective tissue (HP:0009025)1.60293243
136Aplasia involving bones of the extremities (HP:0009825)1.60080364
137Aplasia involving bones of the upper limbs (HP:0009823)1.60080364
138Aplasia of the phalanges of the hand (HP:0009802)1.60080364
139Achilles tendon contracture (HP:0001771)1.59279412
140Anonychia (HP:0001798)1.59018553
141Abnormal number of erythroid precursors (HP:0012131)1.58181011
142Ulnar claw (HP:0001178)1.57671460
143Urticaria (HP:0001025)1.56542603
144Asthma (HP:0002099)1.53899998
145Sensory axonal neuropathy (HP:0003390)1.52726543
146Skin pits (HP:0100276)1.51461438
147Abnormality of the distal phalanges of the toes (HP:0010182)1.50008425
148Amelogenesis imperfecta (HP:0000705)1.48529040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.06838879
2MAPKAPK35.00320058
3MST1R4.78021415
4ACVR1B4.35504730
5STK393.80747708
6FER3.66099729
7MAP3K32.96015961
8EPHB22.89142256
9MAP3K22.74776113
10RPS6KB22.63742313
11LATS12.58710517
12OXSR12.34784499
13PIK3CA2.34392216
14TRPM72.12927056
15EPHA22.08663352
16ERBB32.03581833
17PRKG21.90881150
18STK241.77362893
19BCR1.70923322
20PTK61.67307899
21MAP3K101.67090922
22ERN11.65936454
23LRRK21.63117545
24FGFR11.58085405
25PIM21.54842541
26STK101.46981321
27MET1.38968517
28DYRK1B1.33683115
29MAPKAPK51.32913151
30FRK1.30248430
31PIK3CG1.22762641
32MAP3K61.22444092
33MAP3K111.21580819
34TESK11.19947048
35GRK11.14608696
36EPHA31.08807636
37BMPR1B1.04612365
38MAP2K21.04265627
39MAP3K11.02310157
40CDK60.96800818
41EPHB10.96198565
42EEF2K0.91744262
43MAP3K70.91537309
44IRAK10.91196579
45PRKAA20.90928264
46MAP3K140.90562534
47IRAK30.87523978
48NLK0.86336942
49MAP2K60.86289222
50RIPK10.84827063
51PDK20.83312709
52AKT30.78906820
53MAPKAPK20.77874758
54ERBB40.77100287
55TAOK10.75687489
56ITK0.74993183
57BMPR20.74356797
58FGFR20.74194478
59MYLK0.73154450
60FGFR30.73069112
61SIK10.72167020
62LMTK20.67495958
63PRKD10.66720414
64PTK20.66568128
65FGFR40.66173809
66STK30.65382537
67MAP2K10.64684788
68PRKCI0.64395749
69ERBB20.62942519
70PAK30.62408344
71MAPK150.58895397
72TTN0.57528219
73ROCK10.57505231
74MAP3K120.56811567
75NEK60.56671477
76PBK0.54992207
77PRPF4B0.53465687
78LATS20.51883707
79GRK60.49865023
80RPS6KB10.49007577
81MAP3K90.48898988
82MAPK70.48279595
83NME10.47028752
84TGFBR20.45670644
85BLK0.45423563
86LIMK10.45069440
87WNK40.44870313
88RPS6KA10.42513081
89TNK20.42402949
90IKBKE0.42319214
91DDR20.39815487
92WNK10.39195307
93TYK20.39087872
94TGFBR10.37953426
95SRPK10.37795275
96PRKCE0.37099675
97PAK40.37001075
98NUAK10.36201150
99IKBKB0.35812621
100CSNK1D0.35357355
101MATK0.35046648
102HIPK20.33729730
103ADRBK10.33352974
104ABL20.33330579
105DMPK0.33039235
106PDPK10.32687312
107CASK0.32686805
108BMX0.31584513
109DYRK30.31400567
110CAMK2D0.31012588
111EIF2AK30.30652221
112PDGFRB0.30599012
113CDC42BPA0.30352536
114RET0.30337561
115ICK0.30253168
116NEK90.29265712
117MELK0.28366318
118STK38L0.28168492
119EPHA40.27755744
120AURKB0.27465386
121SGK4940.27030008
122SGK2230.27030008
123OBSCN0.26946780
124RPS6KL10.26848128
125RPS6KC10.26848128
126GRK50.26780854
127PRKCA0.26018903
128JAK10.25948739
129ABL10.25345087
130PKN10.25219454
131GSK3A0.24994256
132CHUK0.24686516
133AURKA0.24638070
134STK110.23927145
135MAPK110.23259296
136IRAK20.22351303
137EIF2AK20.22125073
138SRC0.22043954
139ILK0.21931674
140PDGFRA0.21651406
141PRKACG0.21524860
142BRSK20.18345880

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.70387611
2Sphingolipid metabolism_Homo sapiens_hsa006003.41702959
3Ribosome_Homo sapiens_hsa030103.02187672
4Linoleic acid metabolism_Homo sapiens_hsa005912.86632545
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.82195889
6Fatty acid elongation_Homo sapiens_hsa000622.44965635
7Arachidonic acid metabolism_Homo sapiens_hsa005902.43030862
8Retinol metabolism_Homo sapiens_hsa008302.30070077
9Histidine metabolism_Homo sapiens_hsa003402.08288451
10Starch and sucrose metabolism_Homo sapiens_hsa005002.06392515
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02751556
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01590365
13Tight junction_Homo sapiens_hsa045301.96872251
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95379907
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93713574
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88894942
17Fat digestion and absorption_Homo sapiens_hsa049751.87088482
18Arginine biosynthesis_Homo sapiens_hsa002201.78446002
19Basal cell carcinoma_Homo sapiens_hsa052171.78379588
20Adherens junction_Homo sapiens_hsa045201.76668194
21Ether lipid metabolism_Homo sapiens_hsa005651.72503144
22Mineral absorption_Homo sapiens_hsa049781.70292250
23ABC transporters_Homo sapiens_hsa020101.66065065
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.62342402
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59268646
26Chemical carcinogenesis_Homo sapiens_hsa052041.55281914
27Phenylalanine metabolism_Homo sapiens_hsa003601.55266189
28Bile secretion_Homo sapiens_hsa049761.47472048
29Hippo signaling pathway_Homo sapiens_hsa043901.39436213
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39345914
31Fructose and mannose metabolism_Homo sapiens_hsa000511.29592185
32Axon guidance_Homo sapiens_hsa043601.27732854
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.27293431
34Nitrogen metabolism_Homo sapiens_hsa009101.26707449
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25550072
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20923473
37Galactose metabolism_Homo sapiens_hsa000521.19242223
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.18561078
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17330243
40Sulfur metabolism_Homo sapiens_hsa009201.16246330
41ECM-receptor interaction_Homo sapiens_hsa045121.16226983
42Glutathione metabolism_Homo sapiens_hsa004801.16016827
43Glycerolipid metabolism_Homo sapiens_hsa005611.09937771
44Bladder cancer_Homo sapiens_hsa052191.08571430
45VEGF signaling pathway_Homo sapiens_hsa043701.08516870
46Melanogenesis_Homo sapiens_hsa049161.07984342
47Proteoglycans in cancer_Homo sapiens_hsa052051.00957085
48Hepatitis C_Homo sapiens_hsa051600.99711426
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96607498
50Renin secretion_Homo sapiens_hsa049240.96461042
51Arginine and proline metabolism_Homo sapiens_hsa003300.95128580
52Pancreatic secretion_Homo sapiens_hsa049720.94766241
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.94316057
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94153701
55Protein digestion and absorption_Homo sapiens_hsa049740.93247645
56Tyrosine metabolism_Homo sapiens_hsa003500.93169491
57Hedgehog signaling pathway_Homo sapiens_hsa043400.92193162
58Caffeine metabolism_Homo sapiens_hsa002320.91710009
59TGF-beta signaling pathway_Homo sapiens_hsa043500.89610479
60Tryptophan metabolism_Homo sapiens_hsa003800.89290803
61p53 signaling pathway_Homo sapiens_hsa041150.87644577
62Gastric acid secretion_Homo sapiens_hsa049710.86805560
63GnRH signaling pathway_Homo sapiens_hsa049120.86410160
64Phototransduction_Homo sapiens_hsa047440.83780870
65Amoebiasis_Homo sapiens_hsa051460.80510328
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79772415
67Fatty acid biosynthesis_Homo sapiens_hsa000610.79226542
68MicroRNAs in cancer_Homo sapiens_hsa052060.70832626
69ErbB signaling pathway_Homo sapiens_hsa040120.70732587
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70244036
71Wnt signaling pathway_Homo sapiens_hsa043100.69013001
72Renin-angiotensin system_Homo sapiens_hsa046140.68823236
73Pertussis_Homo sapiens_hsa051330.68341195
74Ras signaling pathway_Homo sapiens_hsa040140.67851880
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66505749
76Vitamin digestion and absorption_Homo sapiens_hsa049770.66439843
77Thyroid cancer_Homo sapiens_hsa052160.64385725
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64199191
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63892765
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62978978
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62175952
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61006637
83Circadian rhythm_Homo sapiens_hsa047100.59047426
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58440733
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.57374911
86Dorso-ventral axis formation_Homo sapiens_hsa043200.57347706
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.56574356
88Ovarian steroidogenesis_Homo sapiens_hsa049130.56496477
89Rap1 signaling pathway_Homo sapiens_hsa040150.54084223
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.52732616
91Toxoplasmosis_Homo sapiens_hsa051450.52463766
92Platelet activation_Homo sapiens_hsa046110.52052527
93Steroid biosynthesis_Homo sapiens_hsa001000.51069176
94Melanoma_Homo sapiens_hsa052180.50970848
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47914869
96Salivary secretion_Homo sapiens_hsa049700.47301470
97Collecting duct acid secretion_Homo sapiens_hsa049660.47284934
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.47249546
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46140800
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.45942213
101Fatty acid metabolism_Homo sapiens_hsa012120.43881867
102Serotonergic synapse_Homo sapiens_hsa047260.43125870
103Choline metabolism in cancer_Homo sapiens_hsa052310.42194277
104Staphylococcus aureus infection_Homo sapiens_hsa051500.41398842
105Small cell lung cancer_Homo sapiens_hsa052220.40457966
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38195023
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37628756
108Salmonella infection_Homo sapiens_hsa051320.37587269
109Long-term depression_Homo sapiens_hsa047300.35932439
110TNF signaling pathway_Homo sapiens_hsa046680.35927776
111beta-Alanine metabolism_Homo sapiens_hsa004100.35307104
112Fatty acid degradation_Homo sapiens_hsa000710.35202944
113PPAR signaling pathway_Homo sapiens_hsa033200.34963321
114Asthma_Homo sapiens_hsa053100.34500208
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34390582
116Tuberculosis_Homo sapiens_hsa051520.33214732
117Endocytosis_Homo sapiens_hsa041440.33018186
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32620680
119Inositol phosphate metabolism_Homo sapiens_hsa005620.32483214
120Oxytocin signaling pathway_Homo sapiens_hsa049210.32445579
121Focal adhesion_Homo sapiens_hsa045100.30611819
122Pathways in cancer_Homo sapiens_hsa052000.30490938
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29531804
124Insulin resistance_Homo sapiens_hsa049310.29078824
125Long-term potentiation_Homo sapiens_hsa047200.28931683
126Peroxisome_Homo sapiens_hsa041460.25639062
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23427443
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.22859784
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.21049119
130Glucagon signaling pathway_Homo sapiens_hsa049220.19072140
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17641300
132Allograft rejection_Homo sapiens_hsa053300.17360063
133Autoimmune thyroid disease_Homo sapiens_hsa053200.16469615
134Thyroid hormone synthesis_Homo sapiens_hsa049180.16453664
135Graft-versus-host disease_Homo sapiens_hsa053320.16365749
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14158217
137Vibrio cholerae infection_Homo sapiens_hsa051100.13204853
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.09453043
139AMPK signaling pathway_Homo sapiens_hsa041520.08904848

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