POFUT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.65219278
2Golgi transport vesicle coating (GO:0048200)5.65219278
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.38693157
4protein retention in ER lumen (GO:0006621)4.23858986
5hemidesmosome assembly (GO:0031581)4.17146126
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15681205
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.98743555
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98743555
9proline biosynthetic process (GO:0006561)3.93328136
10skin morphogenesis (GO:0043589)3.87393659
11mitotic chromosome condensation (GO:0007076)3.65896024
12desmosome organization (GO:0002934)3.51605634
13positive regulation of gamma-delta T cell activation (GO:0046645)3.49342092
14antigen processing and presentation of endogenous antigen (GO:0019883)3.49119153
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.46499236
16negative regulation of granulocyte differentiation (GO:0030853)3.45415706
17positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.44039862
18DNA unwinding involved in DNA replication (GO:0006268)3.36668236
19cell-substrate adherens junction assembly (GO:0007045)3.36119216
20focal adhesion assembly (GO:0048041)3.36119216
21COPII vesicle coating (GO:0048208)3.29552750
22regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.27424943
23positive regulation of histone deacetylation (GO:0031065)3.25364353
24negative regulation of fibrinolysis (GO:0051918)3.20013733
25protein heterotrimerization (GO:0070208)3.16927716
26nuclear pore organization (GO:0006999)3.16532296
27protein localization to endosome (GO:0036010)3.12383175
28regulation of plasminogen activation (GO:0010755)3.07459745
29insulin-like growth factor receptor signaling pathway (GO:0048009)3.05083170
30epithelial cell-cell adhesion (GO:0090136)3.02032283
31peptidyl-proline hydroxylation (GO:0019511)3.00681757
32protein hydroxylation (GO:0018126)2.98354895
33protein carboxylation (GO:0018214)2.96070238
34peptidyl-glutamic acid carboxylation (GO:0017187)2.96070238
35protein maturation by protein folding (GO:0022417)2.95393459
36cell adhesion mediated by integrin (GO:0033627)2.95117651
37apoptotic cell clearance (GO:0043277)2.95084079
38proline metabolic process (GO:0006560)2.93339546
39collagen fibril organization (GO:0030199)2.92676479
40negative regulation of phagocytosis (GO:0050765)2.90341351
41endodermal cell differentiation (GO:0035987)2.88021417
42regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86268416
43definitive hemopoiesis (GO:0060216)2.83306143
44iron ion import (GO:0097286)2.80337007
45regulation of glucose import in response to insulin stimulus (GO:2001273)2.79950744
46vesicle coating (GO:0006901)2.78007839
47neuron projection extension involved in neuron projection guidance (GO:1902284)2.77702178
48axon extension involved in axon guidance (GO:0048846)2.77702178
49regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77322308
50activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76975409
51positive thymic T cell selection (GO:0045059)2.75098199
52positive regulation of natural killer cell differentiation (GO:0032825)2.74912919
53cellular protein complex localization (GO:0034629)2.73415385
54positive regulation of nuclease activity (GO:0032075)2.71739426
55activation of Rac GTPase activity (GO:0032863)2.71553315
56pore complex assembly (GO:0046931)2.70062852
57regulation of fibrinolysis (GO:0051917)2.69505342
58paraxial mesoderm development (GO:0048339)2.67917199
59regulation of interleukin-12 biosynthetic process (GO:0045075)2.66211424
60regulation of gamma-delta T cell differentiation (GO:0045586)2.65113841
61branching involved in mammary gland duct morphogenesis (GO:0060444)2.64690467
62membrane protein ectodomain proteolysis (GO:0006509)2.62611931
63vascular endothelial growth factor signaling pathway (GO:0038084)2.61287456
64negative regulation of erythrocyte differentiation (GO:0045647)2.60392640
65embryonic retina morphogenesis in camera-type eye (GO:0060059)2.59794433
664-hydroxyproline metabolic process (GO:0019471)2.59235248
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.58978458
68regulation of gamma-delta T cell activation (GO:0046643)2.57213254
69positive regulation of osteoblast proliferation (GO:0033690)2.56994344
70regulation of integrin activation (GO:0033623)2.56588683
71germ cell migration (GO:0008354)2.56502419
72endoplasmic reticulum unfolded protein response (GO:0030968)2.55926359
73regulation of translational termination (GO:0006449)2.53723534
74very-low-density lipoprotein particle assembly (GO:0034379)2.52616307
75regulation of early endosome to late endosome transport (GO:2000641)2.52427752
76substrate-dependent cell migration (GO:0006929)2.52426306
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.51696903
78regulation of cholesterol homeostasis (GO:2000188)2.48748694
79ER-nucleus signaling pathway (GO:0006984)2.48690896
80mesodermal cell differentiation (GO:0048333)2.47432783
81positive regulation of endothelial cell apoptotic process (GO:2000353)2.47346086
82glutamine family amino acid biosynthetic process (GO:0009084)2.47245164
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47217816
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.47217816
85modulation by symbiont of host immune response (GO:0052553)2.47217816
86positive regulation by symbiont of host defense response (GO:0052509)2.47217816
87modulation by symbiont of host defense response (GO:0052031)2.47217816
88modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47217816
89mitotic sister chromatid segregation (GO:0000070)2.46431377
90nucleobase-containing small molecule interconversion (GO:0015949)2.44181532
91establishment of apical/basal cell polarity (GO:0035089)2.43530706
92dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.42814561
93antigen processing and presentation via MHC class Ib (GO:0002475)2.42669492
94negative regulation of fatty acid transport (GO:2000192)2.42101397
95protein N-linked glycosylation via asparagine (GO:0018279)2.41637358
96regulation of cholesterol biosynthetic process (GO:0045540)2.41480661
97cell-substrate junction assembly (GO:0007044)2.41381933
98regulation of nuclease activity (GO:0032069)2.41115129
99nucleotide-sugar biosynthetic process (GO:0009226)2.40452612
100peptidyl-asparagine modification (GO:0018196)2.40444059
101basement membrane organization (GO:0071711)2.40112777
102mannose metabolic process (GO:0006013)2.38995735
103formation of translation preinitiation complex (GO:0001731)2.38708788
104cellular response to epidermal growth factor stimulus (GO:0071364)2.38129629
105protein complex localization (GO:0031503)2.37720593
106positive regulation of B cell differentiation (GO:0045579)2.37604875
107epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36919853
108growth hormone receptor signaling pathway (GO:0060396)2.36690224
109barbed-end actin filament capping (GO:0051016)2.36539361
110regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.36232204
111hypotonic response (GO:0006971)2.35856718
112peptidyl-lysine dimethylation (GO:0018027)2.35553185
113regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35227674
114apoptotic process involved in morphogenesis (GO:0060561)2.34722030
115cellular response to unfolded protein (GO:0034620)2.34383250
116chondrocyte proliferation (GO:0035988)2.33167506
117pentose-phosphate shunt (GO:0006098)2.33007703
118protein localization to microtubule (GO:0035372)2.32848147
119pre-miRNA processing (GO:0031054)2.32596906
120mitotic sister chromatid cohesion (GO:0007064)2.32491178
121Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32464245
122glucose catabolic process (GO:0006007)2.32445379
123mesenchymal-epithelial cell signaling (GO:0060638)2.32191438
124pinocytosis (GO:0006907)2.31873361
125response to fluid shear stress (GO:0034405)2.31328150
126maternal placenta development (GO:0001893)2.31170812
127regulation of B cell receptor signaling pathway (GO:0050855)2.30946914
128regulation of extracellular matrix disassembly (GO:0010715)2.30211409
129regulation of transforming growth factor beta1 production (GO:0032908)2.29626399
130mitotic cytokinesis (GO:0000281)2.29364604
131regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.29183536
132protein N-linked glycosylation (GO:0006487)2.28928879
133negative regulation of chondrocyte differentiation (GO:0032331)2.28551489
134mRNA stabilization (GO:0048255)2.28367950
135RNA stabilization (GO:0043489)2.28367950
136positive regulation of protein deacetylation (GO:0090312)2.28354723
137hippo signaling (GO:0035329)2.26822539
138nuclear pore complex assembly (GO:0051292)2.26473993
139chromosome condensation (GO:0030261)2.26175258
140muscle cell migration (GO:0014812)2.26033026
141JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.25990723
142cytoplasmic mRNA processing body assembly (GO:0033962)2.25699379
143cellular response to zinc ion (GO:0071294)2.23859419
144low-density lipoprotein particle clearance (GO:0034383)2.22126052
145negative regulation of translation, ncRNA-mediated (GO:0040033)2.21318066
146regulation of translation, ncRNA-mediated (GO:0045974)2.21318066
147negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.21318066
148I-kappaB phosphorylation (GO:0007252)2.21047758
149histone H3-K36 demethylation (GO:0070544)2.20095054
150collagen metabolic process (GO:0032963)2.19680041
151regulation of interferon-beta biosynthetic process (GO:0045357)2.19538086
152regulation of translational fidelity (GO:0006450)2.19275996
153wound healing, spreading of epidermal cells (GO:0035313)2.18555481
154positive regulation of SMAD protein import into nucleus (GO:0060391)2.18517864
155anatomical structure regression (GO:0060033)2.17675234
156hyaluronan catabolic process (GO:0030214)2.15952081
157natural killer cell differentiation (GO:0001779)2.15840263
158cortical actin cytoskeleton organization (GO:0030866)2.15408348
159histone H3-K4 trimethylation (GO:0080182)2.13933218
160collagen catabolic process (GO:0030574)2.13559464
161positive regulation of blood vessel endothelial cell migration (GO:0043536)2.13222485
162endothelial cell morphogenesis (GO:0001886)2.12509288
163venous blood vessel morphogenesis (GO:0048845)2.12163330
164multicellular organismal macromolecule metabolic process (GO:0044259)2.10722983
165cell proliferation involved in metanephros development (GO:0072203)2.09561834
166cellular response to growth hormone stimulus (GO:0071378)2.09235106
167dosage compensation (GO:0007549)2.08047503
168response to laminar fluid shear stress (GO:0034616)2.07974701
169response to UV-C (GO:0010225)2.07948298
170negative regulation of interleukin-12 production (GO:0032695)2.07509814
171neural tube development (GO:0021915)2.07415560
172regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.06567163
173adherens junction assembly (GO:0034333)2.05292459
174hyaluronan metabolic process (GO:0030212)2.05281139
175integrin-mediated signaling pathway (GO:0007229)2.05270578
176positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.04665663
177heart morphogenesis (GO:0003007)2.04624336
178planar cell polarity pathway involved in neural tube closure (GO:0090179)2.04182965
179retina vasculature morphogenesis in camera-type eye (GO:0061299)2.04179233
180atrial septum morphogenesis (GO:0060413)2.03235344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.39917183
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.96675897
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.87769887
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.64362492
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51751543
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.32761586
7ZNF263_19887448_ChIP-Seq_K562_Human3.28621649
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.14828215
9MYC_22102868_ChIP-Seq_BL_Human2.85588651
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.76467564
11AR_21909140_ChIP-Seq_LNCAP_Human2.69051970
12SCL_19346495_ChIP-Seq_HPC-7_Human2.61746981
13VDR_21846776_ChIP-Seq_THP-1_Human2.57594993
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49672971
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47661118
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.37517824
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36584690
18TCF7_22412390_ChIP-Seq_EML_Mouse2.28798100
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.25015080
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22902537
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22305965
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11291560
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10839694
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02266374
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.01492840
26* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.01284454
27* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00873440
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99392978
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99173885
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99038498
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.97914624
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95772222
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93773957
34KDM2B_26808549_Chip-Seq_DND41_Human1.92232244
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.91411561
36VDR_24763502_ChIP-Seq_THP-1_Human1.88745107
37MAF_26560356_Chip-Seq_TH1_Human1.88718881
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86637461
39RACK7_27058665_Chip-Seq_MCF-7_Human1.85173618
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85037928
41RUNX_20019798_ChIP-Seq_JUKART_Human1.83632077
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78360108
43UTX_26944678_Chip-Seq_JUKART_Human1.76725452
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76694083
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72513315
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71351055
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71023432
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68795362
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.65939876
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64906299
51CLOCK_20551151_ChIP-Seq_293T_Human1.64569315
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64093494
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64060878
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63526016
55ATF3_27146783_Chip-Seq_COLON_Human1.62445277
56SPI1_23127762_ChIP-Seq_K562_Human1.61134914
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58952699
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58859765
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58672518
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.57122176
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54877090
62TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.54487478
63MYB_26560356_Chip-Seq_TH2_Human1.53788144
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51432945
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51425986
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50724270
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50660210
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50637997
69MYB_26560356_Chip-Seq_TH1_Human1.49834356
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.47247661
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45487184
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44539587
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43336197
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.42898979
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42350012
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42283721
77BRD4_25478319_ChIP-Seq_HGPS_Human1.41264075
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41006164
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39933484
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39514449
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39219911
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38375392
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38288474
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37490765
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37478155
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.36372932
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.34226794
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33136910
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32905361
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.32205100
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30164393
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29747055
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29687100
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29509377
95* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29077083
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.28962589
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28911509
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.28010844
99TP53_22127205_ChIP-Seq_IMR90_Human1.27630359
100NCOR1_26117541_ChIP-Seq_K562_Human1.26691111
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26185820
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24696719
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24034531
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23070595
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22797630
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22482595
107XRN2_22483619_ChIP-Seq_HELA_Human1.22008561
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20834182
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20121431
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.18720296
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18477066
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17446276
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16576132
114PU_27001747_Chip-Seq_BMDM_Mouse1.16404287
115CHD1_26751641_Chip-Seq_LNCaP_Human1.16200396
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15939228
117* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15505335
118GATA1_19941826_ChIP-Seq_K562_Human1.14611577
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12848423
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12488025
121LXR_22292898_ChIP-Seq_THP-1_Human1.12454913
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12244853
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12244853
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11149929
125DCP1A_22483619_ChIP-Seq_HELA_Human1.10767061
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10326843
127GATA1_22025678_ChIP-Seq_K562_Human1.09504733
128VDR_24787735_ChIP-Seq_THP-1_Human1.09426638
129E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09166093
130TBX20_22080862_ChIP-Seq_HEART_Mouse1.08683025
131TBX20_22328084_ChIP-Seq_HEART_Mouse1.08683025
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08430380
133NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06527072
134SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06214800
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06009655
136GATA6_25053715_ChIP-Seq_YYC3_Human1.05151068
137SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04899479
138POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04259557
139* GATA1_19941827_ChIP-Seq_MEL_Mouse1.03096730
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02648914
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02439119
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01376806
143E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01112593
144ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00867731
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00082678
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.98578092
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.98466985
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98191201
149* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97345032
150KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96721630
151TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96565424
152GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96531806
153EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96417349
154SPI1_23547873_ChIP-Seq_NB4_Human0.96157114
155NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95753585
156ESR1_20079471_ChIP-ChIP_T-47D_Human0.95624330
157TET1_21451524_ChIP-Seq_MESCs_Mouse0.95512007
158SOX17_20123909_ChIP-Seq_XEN_Mouse0.94664677
159KDM2B_26808549_Chip-Seq_K562_Human0.94489069
160ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94384082
161PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93654719
162HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92845240
163* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92842096
164MAF_26560356_Chip-Seq_TH2_Human0.91942367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.12008234
2MP0003705_abnormal_hypodermis_morpholog3.39619677
3MP0005275_abnormal_skin_tensile2.51607874
4MP0003300_gastrointestinal_ulcer2.47862406
5MP0005503_abnormal_tendon_morphology2.43366890
6MP0000569_abnormal_digit_pigmentation2.28641815
7MP0005076_abnormal_cell_differentiation2.24707124
8MP0010234_abnormal_vibrissa_follicle2.23969483
9MP0010352_gastrointestinal_tract_polyps2.13297085
10MP0002396_abnormal_hematopoietic_system2.11512135
11MP0004808_abnormal_hematopoietic_stem2.07830699
12MP0009278_abnormal_bone_marrow2.07199796
13MP0003279_aneurysm2.05992920
14MP0003566_abnormal_cell_adhesion2.03292560
15MP0004272_abnormal_basement_membrane1.91823178
16MP0005451_abnormal_body_composition1.85214323
17MP0005409_darkened_coat_color1.84812390
18MP0003950_abnormal_plasma_membrane1.83164404
19MP0005360_urolithiasis1.82405588
20MP0002166_altered_tumor_susceptibility1.79236974
21MP0004233_abnormal_muscle_weight1.76525881
22MP0001958_emphysema1.76290165
23MP0000733_abnormal_muscle_development1.76158111
24MP0000537_abnormal_urethra_morphology1.75275441
25MP0001849_ear_inflammation1.72401435
26MP0000685_abnormal_immune_system1.72072291
27MP0010030_abnormal_orbit_morphology1.70617750
28MP0003303_peritoneal_inflammation1.67817127
29MP0004858_abnormal_nervous_system1.67317809
30MP0005058_abnormal_lysosome_morphology1.60767295
31MP0003091_abnormal_cell_migration1.60430252
32MP0006054_spinal_hemorrhage1.60326869
33MP0005257_abnormal_intraocular_pressure1.60037350
34MP0000767_abnormal_smooth_muscle1.51976222
35MP0001661_extended_life_span1.47642808
36MP0010307_abnormal_tumor_latency1.47548409
37MP0009840_abnormal_foam_cell1.45924385
38MP0003045_fibrosis1.45862585
39MP0001835_abnormal_antigen_presentation1.45473966
40MP0000003_abnormal_adipose_tissue1.42538166
41MP0003111_abnormal_nucleus_morphology1.42206507
42MP0003941_abnormal_skin_development1.35340347
43MP0003252_abnormal_bile_duct1.34418132
44MP0002060_abnormal_skin_morphology1.33005498
45MP0001790_abnormal_immune_system1.32470878
46MP0005387_immune_system_phenotype1.32470878
47MP0001730_embryonic_growth_arrest1.30834910
48MP0000751_myopathy1.30502546
49MP0000762_abnormal_tongue_morphology1.30299503
50MP0002006_tumorigenesis1.28895152
51MP0001348_abnormal_lacrimal_gland1.27728676
52MP0001545_abnormal_hematopoietic_system1.24586866
53MP0005397_hematopoietic_system_phenotyp1.24586866
54MP0001800_abnormal_humoral_immune1.24350006
55MP0003693_abnormal_embryo_hatching1.23679621
56MP0005023_abnormal_wound_healing1.21882810
57MP0002933_joint_inflammation1.21430418
58MP0009384_cardiac_valve_regurgitation1.20682107
59MP0005501_abnormal_skin_physiology1.19885114
60MP0004957_abnormal_blastocyst_morpholog1.19507253
61MP0000013_abnormal_adipose_tissue1.19328347
62MP0001915_intracranial_hemorrhage1.19198792
63MP0002452_abnormal_antigen_presenting1.16616401
64MP0009780_abnormal_chondrocyte_physiolo1.15830515
65MP0003453_abnormal_keratinocyte_physiol1.15752737
66MP0001879_abnormal_lymphatic_vessel1.12854978
67MP0004510_myositis1.12323297
68MP0003828_pulmonary_edema1.12245048
69MP0003385_abnormal_body_wall1.11705974
70MP0005464_abnormal_platelet_physiology1.10900847
71MP0004947_skin_inflammation1.10825426
72MP0003115_abnormal_respiratory_system1.10420360
73MP0003315_abnormal_perineum_morphology1.10415681
74MP0004185_abnormal_adipocyte_glucose1.09769984
75MP0003436_decreased_susceptibility_to1.08598528
76MP0010368_abnormal_lymphatic_system1.07657094
77MP0002928_abnormal_bile_duct1.06685775
78MP0003868_abnormal_feces_composition1.04854617
79MP0003448_altered_tumor_morphology1.04469756
80MP0005623_abnormal_meninges_morphology1.04418915
81MP0002796_impaired_skin_barrier1.04037610
82MP0002398_abnormal_bone_marrow1.03689728
83MP0008932_abnormal_embryonic_tissue1.03575520
84MP0000534_abnormal_ureter_morphology1.01926381
85MP0004130_abnormal_muscle_cell1.01862548
86MP0003172_abnormal_lysosome_physiology1.00050370
87MP0000383_abnormal_hair_follicle0.99919960
88MP0000428_abnormal_craniofacial_morphol0.99524523
89MP0004264_abnormal_extraembryonic_tissu0.98575338
90MP0003077_abnormal_cell_cycle0.98457881
91MP0000350_abnormal_cell_proliferation0.98377872
92MP0002419_abnormal_innate_immunity0.96927007
93MP0002998_abnormal_bone_remodeling0.96461575
94* MP0003984_embryonic_growth_retardation0.96457776
95MP0004197_abnormal_fetal_growth/weight/0.96107810
96MP0010630_abnormal_cardiac_muscle0.95251971
97* MP0001672_abnormal_embryogenesis/_devel0.95154876
98* MP0005380_embryogenesis_phenotype0.95154876
99MP0005666_abnormal_adipose_tissue0.94334523
100MP0009053_abnormal_anal_canal0.94330378
101MP0002420_abnormal_adaptive_immunity0.93821132
102MP0000467_abnormal_esophagus_morphology0.93598565
103MP0003942_abnormal_urinary_system0.93325025
104MP0002089_abnormal_postnatal_growth/wei0.93295639
105MP0001819_abnormal_immune_cell0.93110010
106MP0002723_abnormal_immune_serum0.93091709
107* MP0002925_abnormal_cardiovascular_devel0.92761303
108* MP0002080_prenatal_lethality0.92674585
109MP0005508_abnormal_skeleton_morphology0.92337497
110MP0001873_stomach_inflammation0.91045045
111MP0005197_abnormal_uvea_morphology0.90733472
112MP0005408_hypopigmentation0.90264821
113* MP0002088_abnormal_embryonic_growth/wei0.89778159
114MP0010155_abnormal_intestine_physiology0.89441899
115MP0005621_abnormal_cell_physiology0.88926951
116MP0002128_abnormal_blood_circulation0.87659742
117MP0000490_abnormal_crypts_of0.86991077
118MP0005025_abnormal_response_to0.86864669
119* MP0001614_abnormal_blood_vessel0.86747137
120MP0000465_gastrointestinal_hemorrhage0.86695450
121MP0000689_abnormal_spleen_morphology0.86689259
122* MP0001216_abnormal_epidermal_layer0.86022273
123MP0001533_abnormal_skeleton_physiology0.85857491
124MP0008007_abnormal_cellular_replicative0.85269647
125MP0000716_abnormal_immune_system0.85092890
126MP0005000_abnormal_immune_tolerance0.84671720
127MP0004782_abnormal_surfactant_physiolog0.84596346
128MP0005330_cardiomyopathy0.84422353
129MP0002722_abnormal_immune_system0.81762455
130MP0000747_muscle_weakness0.81618908
131MP0010678_abnormal_skin_adnexa0.80926119
132MP0002405_respiratory_system_inflammati0.80517734
133MP0000703_abnormal_thymus_morphology0.80304964
134MP0003191_abnormal_cellular_cholesterol0.79063298
135MP0005390_skeleton_phenotype0.78341681
136MP0002084_abnormal_developmental_patter0.78211654
137MP0000566_synostosis0.78197776
138MP0003567_abnormal_fetal_cardiomyocyte0.78006257
139MP0002877_abnormal_melanocyte_morpholog0.77769512
140MP0002092_abnormal_eye_morphology0.77661473
141MP0002429_abnormal_blood_cell0.77245453
142MP0005174_abnormal_tail_pigmentation0.76843065
143MP0000678_abnormal_parathyroid_gland0.76777392
144* MP0001697_abnormal_embryo_size0.76496961
145MP0002269_muscular_atrophy0.76465236
146* MP0002085_abnormal_embryonic_tissue0.76347795
147MP0002896_abnormal_bone_mineralization0.76320782
148MP0004087_abnormal_muscle_fiber0.76209393
149* MP0000266_abnormal_heart_morphology0.75746416
150MP0003123_paternal_imprinting0.75505367
151MP0009697_abnormal_copulation0.75056320
152MP0002139_abnormal_hepatobiliary_system0.74726664
153MP0010094_abnormal_chromosome_stability0.74715720
154MP0005375_adipose_tissue_phenotype0.74568227
155MP0000759_abnormal_skeletal_muscle0.74460994
156MP0000858_altered_metastatic_potential0.73877895
157MP0002697_abnormal_eye_size0.73650326
158MP0006138_congestive_heart_failure0.73605066
159MP0002113_abnormal_skeleton_development0.72678984
160* MP0002086_abnormal_extraembryonic_tissu0.72320267
161MP0001299_abnormal_eye_distance/0.72269612
162MP0009115_abnormal_fat_cell0.72101232
163MP0001243_abnormal_dermal_layer0.72032012

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.20359603
2Cerebral aneurysm (HP:0004944)4.14739114
3Premature rupture of membranes (HP:0001788)3.65849358
4Shallow orbits (HP:0000586)3.58238089
5Aortic aneurysm (HP:0004942)3.56699461
6Hyperacusis (HP:0010780)3.53212574
7Bladder diverticulum (HP:0000015)3.33659748
8Broad metatarsal (HP:0001783)3.29168059
9Aortic dissection (HP:0002647)3.27930343
10Deep venous thrombosis (HP:0002625)3.26975176
11Elfin facies (HP:0004428)3.25844590
12Renovascular hypertension (HP:0100817)3.17272887
13Renal duplication (HP:0000075)2.99281970
14Mitral valve prolapse (HP:0001634)2.95583833
15Short 4th metacarpal (HP:0010044)2.92074347
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92074347
17Ankle contracture (HP:0006466)2.91436347
18Dilatation of the ascending aorta (HP:0005111)2.88693281
19Spinal rigidity (HP:0003306)2.86440201
20Flat cornea (HP:0007720)2.85969347
21Bowel diverticulosis (HP:0005222)2.83589490
22Short nail (HP:0001799)2.79512874
23Atrophic scars (HP:0001075)2.76637130
24Chronic otitis media (HP:0000389)2.73835022
25Hematochezia (HP:0002573)2.72838228
26Abnormality of dentin (HP:0010299)2.64243837
27Flat acetabular roof (HP:0003180)2.63418063
28Overriding aorta (HP:0002623)2.61215730
29Asymmetry of the thorax (HP:0001555)2.50966215
30Aneurysm (HP:0002617)2.43512167
31Spinal cord lesions (HP:0100561)2.42490564
32Syringomyelia (HP:0003396)2.42490564
33Abnormality of carpal bone ossification (HP:0006257)2.41762286
34Increased density of long bones (HP:0006392)2.41512337
35Rectal prolapse (HP:0002035)2.37015378
36Abnormality of the 4th metacarpal (HP:0010012)2.36474809
37Subacute progressive viral hepatitis (HP:0006572)2.35076180
38Peritonitis (HP:0002586)2.34431579
39Mitral stenosis (HP:0001718)2.33905579
40Achilles tendon contracture (HP:0001771)2.33423904
41Elbow flexion contracture (HP:0002987)2.33124154
42Genu recurvatum (HP:0002816)2.30695100
43Hallux valgus (HP:0001822)2.30503125
44Abnormality of the Achilles tendon (HP:0005109)2.30493672
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.30459371
46Osteolytic defects of the hand bones (HP:0009699)2.30459371
47Abnormality of the acetabulum (HP:0003170)2.28755288
48Deviation of the hallux (HP:0010051)2.27076812
49Abnormal ossification of hand bones (HP:0005921)2.26499443
50Cervical subluxation (HP:0003308)2.26346519
51Mesomelia (HP:0003027)2.26256587
52Abnormal delivery (HP:0001787)2.23065428
53Soft skin (HP:0000977)2.22620561
54Type 1 muscle fiber predominance (HP:0003803)2.21451137
55Disproportionate tall stature (HP:0001519)2.20320016
56Broad face (HP:0000283)2.20232389
57Increased connective tissue (HP:0009025)2.19461008
58Absent frontal sinuses (HP:0002688)2.18631701
59Trismus (HP:0000211)2.16673283
60Neonatal short-limb short stature (HP:0008921)2.15726101
61Back pain (HP:0003418)2.14450743
62Insomnia (HP:0100785)2.14394856
63Thrombocytosis (HP:0001894)2.13727424
64Thin bony cortex (HP:0002753)2.12656600
65Fragile skin (HP:0001030)2.11423526
66Cardiovascular calcification (HP:0011915)2.10865124
67Natal tooth (HP:0000695)2.10172605
68Ulnar bowing (HP:0003031)2.07976116
69Abnormality of the distal phalanges of the toes (HP:0010182)2.06413543
70Mildly elevated creatine phosphokinase (HP:0008180)2.03371442
71Blue sclerae (HP:0000592)2.03166736
72Coxa vara (HP:0002812)2.02568394
73Abnormality of the fingertips (HP:0001211)2.01381279
74Slender build (HP:0001533)1.99734473
75Macroorchidism (HP:0000053)1.99080375
76Advanced eruption of teeth (HP:0006288)1.98904874
77Autoimmune thrombocytopenia (HP:0001973)1.98678023
78Periodontitis (HP:0000704)1.97526535
79Wrist flexion contracture (HP:0001239)1.97228863
80Distal upper limb amyotrophy (HP:0007149)1.95513687
81Upper limb amyotrophy (HP:0009129)1.95513687
82Generalized amyotrophy (HP:0003700)1.94936225
83Hyperextensible skin (HP:0000974)1.92673509
84High pitched voice (HP:0001620)1.92504533
85Breech presentation (HP:0001623)1.90539688
86Abnormality of the peritoneum (HP:0002585)1.88808038
87Bicuspid aortic valve (HP:0001647)1.87135363
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.86873313
89Camptodactyly of toe (HP:0001836)1.86173471
90Abnormal platelet volume (HP:0011876)1.85475109
91Increased mean platelet volume (HP:0011877)1.83402448
92Abnormality of the intrinsic pathway (HP:0010989)1.82806291
93Pterygium (HP:0001059)1.82685620
94Arterial tortuosity (HP:0005116)1.82593196
95Vascular calcification (HP:0004934)1.82135123
96Increased variability in muscle fiber diameter (HP:0003557)1.80291579
97Hemorrhage of the eye (HP:0011885)1.80231031
98Radial bowing (HP:0002986)1.79608278
99Nonimmune hydrops fetalis (HP:0001790)1.79093934
100Myocardial infarction (HP:0001658)1.78976993
101Ectopia lentis (HP:0001083)1.78889907
102Striae distensae (HP:0001065)1.78802037
103Long eyelashes (HP:0000527)1.78459706
104Mitral regurgitation (HP:0001653)1.78055070
105Joint laxity (HP:0001388)1.77499491
106Enlarged penis (HP:0000040)1.76944517
107Centrally nucleated skeletal muscle fibers (HP:0003687)1.76605970
108Deviation of the thumb (HP:0009603)1.76416625
109Narrow palate (HP:0000189)1.75308130
110Vascular tortuosity (HP:0004948)1.75287538
111Spinal cord compression (HP:0002176)1.73872338
112Cupped ribs (HP:0000887)1.73331093
113Right ventricular cardiomyopathy (HP:0011663)1.73159675
114Abnormal hand bone ossification (HP:0010660)1.72927155
115Abnormality of oral frenula (HP:0000190)1.72692185
116Increased nuchal translucency (HP:0010880)1.72223572
117Abnormality of the common coagulation pathway (HP:0010990)1.71864826
118Toxemia of pregnancy (HP:0100603)1.71191615
119Distal lower limb amyotrophy (HP:0008944)1.70442562
120Follicular hyperkeratosis (HP:0007502)1.70104900
121Premature skin wrinkling (HP:0100678)1.69704524
122Lymphangioma (HP:0100764)1.68113285
123Entropion (HP:0000621)1.67538451
124Reduced subcutaneous adipose tissue (HP:0003758)1.67503689
125Arnold-Chiari malformation (HP:0002308)1.67425752
126Bowed forearm bones (HP:0003956)1.67247668
127Bowing of the arm (HP:0006488)1.67247668
128Viral hepatitis (HP:0006562)1.67005065
129Wormian bones (HP:0002645)1.66911291
130Delayed closure of the anterior fontanelle (HP:0001476)1.66787089
131Broad ribs (HP:0000885)1.66627317
132Abnormality of skeletal muscle fiber size (HP:0012084)1.66259876
133Abnormality of the diencephalon (HP:0010662)1.66072153
134Spontaneous hematomas (HP:0007420)1.65731430
135Abnormality of the calcaneus (HP:0008364)1.65674949
136Megalocornea (HP:0000485)1.65261448
137Arterial thrombosis (HP:0004420)1.64547953
138Delayed cranial suture closure (HP:0000270)1.64334959
139Ureteral obstruction (HP:0006000)1.63662174
140Abnormal foot bone ossification (HP:0010675)1.62939220
141Coronal craniosynostosis (HP:0004440)1.62732430
142Neonatal death (HP:0003811)1.62361415
143Vertebral compression fractures (HP:0002953)1.62072538
144Ankyloglossia (HP:0010296)1.62068089
145Rhizomelia (HP:0008905)1.61865583
146Cellulitis (HP:0100658)1.61787136
147Persistence of primary teeth (HP:0006335)1.61777590
148Biconcave vertebral bodies (HP:0004586)1.60961117
149Obsessive-compulsive behavior (HP:0000722)1.60114342
150Abnormality of the umbilical cord (HP:0010881)1.59562477
151Long palpebral fissure (HP:0000637)1.59510781
152Colitis (HP:0002583)1.59007978
153Flexion contracture of toe (HP:0005830)1.58762355
154Joint contractures involving the joints of the feet (HP:0100492)1.58762355
155Long toe (HP:0010511)1.58761203
156Thin skin (HP:0000963)1.56539234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.51859064
2PKN23.46299049
3EPHA23.26495520
4MST1R3.04835748
5TTN3.02459637
6SMG12.88393595
7MAP3K102.78080316
8EEF2K2.73290868
9IRAK32.72629740
10SIK12.59185253
11CDK122.57677218
12TGFBR22.27523655
13RIPK12.20624159
14MET2.10588920
15PTK62.08069267
16CAMK1D2.05719217
17JAK31.98794603
18LATS21.94333957
19MAP4K11.93230073
20PTK21.85605813
21PDGFRA1.81958817
22FLT31.78286066
23TYK21.75290030
24JAK11.67388332
25ERN11.65350491
26DDR21.62771041
27KIT1.58628057
28LATS11.54521968
29CSF1R1.52191002
30CAMK1G1.51639412
31BUB11.50059948
32NTRK11.44262364
33CDK81.43360567
34SIK21.39348096
35BRD41.38465030
36ERBB41.33639632
37PRPF4B1.30869030
38FGFR31.30689468
39PBK1.29986327
40MAP3K141.23180418
41FGFR41.20541824
42PAK41.19087683
43CDK61.18287105
44RPS6KA41.18003758
45STK101.17890949
46EIF2AK11.16746361
47NEK21.14458455
48PDGFRB1.14205545
49ICK1.11258320
50LRRK21.10303851
51TESK11.09406138
52HCK1.08972330
53PAK21.08691117
54CDK71.07705979
55EPHB11.06012965
56MTOR1.04813246
57BTK1.03519156
58STK31.02597556
59TSSK61.00798729
60MAPK110.98767036
61MAP2K30.96883001
62NEK10.95931645
63EPHB20.95224809
64DMPK0.95014376
65TBK10.93569115
66TTK0.93526604
67CDK40.93150034
68TGFBR10.90856938
69ZAP700.89319031
70MAP3K70.88068690
71MOS0.87118189
72BMX0.85970192
73NME20.83988154
74MYLK0.81962624
75CHUK0.80489049
76STK40.79847866
77ARAF0.77706457
78CLK10.77120113
79JAK20.76912980
80FGFR10.76615945
81SCYL20.75932776
82NEK90.74384270
83PIK3CA0.74016781
84BRSK10.73397499
85BLK0.72575053
86EPHA30.72322781
87MELK0.71846550
88TAOK20.71601387
89IKBKB0.71509496
90ITK0.70563690
91KSR20.69857556
92LIMK10.67362022
93LCK0.67312370
94FGFR20.66802176
95TEC0.65247690
96CDC42BPA0.64963504
97FRK0.64127130
98PASK0.64077665
99ALK0.63964725
100TRPM70.62775335
101ILK0.62611345
102LMTK20.60119695
103CSK0.58263986
104AURKB0.57636139
105PRKCH0.57300823
106PIM10.57077120
107RPS6KC10.56886341
108RPS6KL10.56886341
109SGK30.56466631
110TIE10.54691160
111MAP3K80.53266214
112STK380.53258640
113IKBKE0.53146313
114CDK90.53034419
115RPS6KA60.52651384
116ATR0.52159231
117RPS6KB20.51578498
118WEE10.51431439
119RET0.51253642
120CHEK20.50645211
121EGFR0.49093354
122BRAF0.48675689
123TXK0.48377207
124PDPK10.47356608
125SYK0.47130232
126CHEK10.46267854
127BRSK20.45115146
128TESK20.45083302
129PRKAA20.44658187
130PRKG20.44146834
131LYN0.43808556
132MAP3K60.43429816
133AURKA0.41347698
134RPS6KA20.40801228
135PRKD20.40676550
136ZAK0.39699360
137KDR0.39673201
138INSR0.39376121
139MAP3K20.38875196
140ABL20.38721201
141IGF1R0.38490428
142AKT20.37279743
143ABL10.37031284
144PIM20.36343486
145IRAK40.36339994
146ROCK20.36269991
147MAP3K30.36092264
148SRC0.35814811
149MAPKAPK30.35672569
150CDC70.35060532
151AKT30.34639922
152SRPK10.31944697
153MAP3K90.31926303

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27812535
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.08481082
3Chronic myeloid leukemia_Homo sapiens_hsa052202.05348695
4Small cell lung cancer_Homo sapiens_hsa052222.04643425
5ECM-receptor interaction_Homo sapiens_hsa045121.97678199
6Biosynthesis of amino acids_Homo sapiens_hsa012301.94382297
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89397819
8Lysine degradation_Homo sapiens_hsa003101.81354734
9Other glycan degradation_Homo sapiens_hsa005111.78280609
10Focal adhesion_Homo sapiens_hsa045101.76072797
11Fructose and mannose metabolism_Homo sapiens_hsa000511.67636917
12Osteoclast differentiation_Homo sapiens_hsa043801.67160132
13Leishmaniasis_Homo sapiens_hsa051401.66278447
14B cell receptor signaling pathway_Homo sapiens_hsa046621.63125042
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61254100
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60832816
17Viral myocarditis_Homo sapiens_hsa054161.60747640
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.58529938
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.57668131
20Pentose phosphate pathway_Homo sapiens_hsa000301.53826784
21Toxoplasmosis_Homo sapiens_hsa051451.53097822
22DNA replication_Homo sapiens_hsa030301.52968192
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51647978
24Proteoglycans in cancer_Homo sapiens_hsa052051.51520408
25Galactose metabolism_Homo sapiens_hsa000521.47391689
26Thyroid cancer_Homo sapiens_hsa052161.47021051
27Complement and coagulation cascades_Homo sapiens_hsa046101.41547247
28Staphylococcus aureus infection_Homo sapiens_hsa051501.38906403
29Carbon metabolism_Homo sapiens_hsa012001.37522983
30MicroRNAs in cancer_Homo sapiens_hsa052061.36849479
31Measles_Homo sapiens_hsa051621.35846442
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35730146
33Arginine biosynthesis_Homo sapiens_hsa002201.35139870
34Vitamin B6 metabolism_Homo sapiens_hsa007501.33855011
35Primary immunodeficiency_Homo sapiens_hsa053401.32144525
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31775942
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31752438
38Notch signaling pathway_Homo sapiens_hsa043301.31431566
39Pancreatic cancer_Homo sapiens_hsa052121.29992548
40Prion diseases_Homo sapiens_hsa050201.28948894
41Acute myeloid leukemia_Homo sapiens_hsa052211.27689811
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24826426
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24096370
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23454125
45Amoebiasis_Homo sapiens_hsa051461.22963061
46Platelet activation_Homo sapiens_hsa046111.22906189
47Malaria_Homo sapiens_hsa051441.22488915
48TNF signaling pathway_Homo sapiens_hsa046681.21596936
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.21423523
50Insulin resistance_Homo sapiens_hsa049311.20534365
51Herpes simplex infection_Homo sapiens_hsa051681.20254959
52Adherens junction_Homo sapiens_hsa045201.15838448
53Hematopoietic cell lineage_Homo sapiens_hsa046401.15830143
54Sulfur relay system_Homo sapiens_hsa041221.15657916
55HTLV-I infection_Homo sapiens_hsa051661.14075859
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13731230
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.13072131
58Hepatitis B_Homo sapiens_hsa051611.10083058
59Non-small cell lung cancer_Homo sapiens_hsa052231.09361684
60Cell cycle_Homo sapiens_hsa041101.09186248
61Antigen processing and presentation_Homo sapiens_hsa046121.08754770
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.07314907
63Apoptosis_Homo sapiens_hsa042101.05448600
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05216295
65One carbon pool by folate_Homo sapiens_hsa006701.04547580
66Basal cell carcinoma_Homo sapiens_hsa052171.03588713
67Viral carcinogenesis_Homo sapiens_hsa052030.99532152
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99486341
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.96709056
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.96657495
71Systemic lupus erythematosus_Homo sapiens_hsa053220.96110601
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94989917
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94935051
74Pyruvate metabolism_Homo sapiens_hsa006200.94693022
75mTOR signaling pathway_Homo sapiens_hsa041500.91553318
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91515160
77Protein digestion and absorption_Homo sapiens_hsa049740.89685944
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89416998
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89123514
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88564284
81Hippo signaling pathway_Homo sapiens_hsa043900.88402012
82T cell receptor signaling pathway_Homo sapiens_hsa046600.87872602
83Nucleotide excision repair_Homo sapiens_hsa034200.86700220
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86505435
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86388767
86Influenza A_Homo sapiens_hsa051640.86089499
87Pathways in cancer_Homo sapiens_hsa052000.85809615
88Colorectal cancer_Homo sapiens_hsa052100.85584963
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.84650389
90Dilated cardiomyopathy_Homo sapiens_hsa054140.83894209
91Renal cell carcinoma_Homo sapiens_hsa052110.83287475
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81231899
93Phenylalanine metabolism_Homo sapiens_hsa003600.80913799
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.80669448
95Chemokine signaling pathway_Homo sapiens_hsa040620.80667281
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80436633
97Prostate cancer_Homo sapiens_hsa052150.79309121
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78578611
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78244212
100Legionellosis_Homo sapiens_hsa051340.78007743
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76932158
102Glioma_Homo sapiens_hsa052140.76089631
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76038978
104HIF-1 signaling pathway_Homo sapiens_hsa040660.75961542
105Endometrial cancer_Homo sapiens_hsa052130.75740070
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74568930
107Bladder cancer_Homo sapiens_hsa052190.74018193
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73737948
109Prolactin signaling pathway_Homo sapiens_hsa049170.73602247
110TGF-beta signaling pathway_Homo sapiens_hsa043500.73296626
111Tuberculosis_Homo sapiens_hsa051520.72838276
112Type II diabetes mellitus_Homo sapiens_hsa049300.71860259
113Fatty acid biosynthesis_Homo sapiens_hsa000610.71716877
114ABC transporters_Homo sapiens_hsa020100.71666733
115Vitamin digestion and absorption_Homo sapiens_hsa049770.70900199
116Renin-angiotensin system_Homo sapiens_hsa046140.70894564
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70128783
118Pertussis_Homo sapiens_hsa051330.69302226
119* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69095833
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69000998
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68871918
122Shigellosis_Homo sapiens_hsa051310.67938935
123Dorso-ventral axis formation_Homo sapiens_hsa043200.67861889
124RNA transport_Homo sapiens_hsa030130.66736669
125PPAR signaling pathway_Homo sapiens_hsa033200.66528057
126Arginine and proline metabolism_Homo sapiens_hsa003300.65888169
127N-Glycan biosynthesis_Homo sapiens_hsa005100.65745193
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63932470
129p53 signaling pathway_Homo sapiens_hsa041150.63738763
130AMPK signaling pathway_Homo sapiens_hsa041520.62124617
131Thyroid hormone synthesis_Homo sapiens_hsa049180.62002179
132Selenocompound metabolism_Homo sapiens_hsa004500.61505427
133Fatty acid metabolism_Homo sapiens_hsa012120.61501823
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61461992
135Insulin signaling pathway_Homo sapiens_hsa049100.61400103
136Hepatitis C_Homo sapiens_hsa051600.60860766
137Starch and sucrose metabolism_Homo sapiens_hsa005000.60144068
138FoxO signaling pathway_Homo sapiens_hsa040680.60060566
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59425450
140Glucagon signaling pathway_Homo sapiens_hsa049220.58946509
141VEGF signaling pathway_Homo sapiens_hsa043700.58653987
142Melanoma_Homo sapiens_hsa052180.58326948
143Bile secretion_Homo sapiens_hsa049760.58233875
144Rap1 signaling pathway_Homo sapiens_hsa040150.56865394
145mRNA surveillance pathway_Homo sapiens_hsa030150.56633232
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54795268
147Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54310044
148Salmonella infection_Homo sapiens_hsa051320.53715262
149Vibrio cholerae infection_Homo sapiens_hsa051100.53421484
150Tight junction_Homo sapiens_hsa045300.52724619
151Pyrimidine metabolism_Homo sapiens_hsa002400.52215896
152Tyrosine metabolism_Homo sapiens_hsa003500.51111180
153Sphingolipid metabolism_Homo sapiens_hsa006000.50052884
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.49926189
155ErbB signaling pathway_Homo sapiens_hsa040120.47885813

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