POFUT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.28173407
2Golgi transport vesicle coating (GO:0048200)9.28173407
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.86563427
4protein retention in ER lumen (GO:0006621)6.29659718
5COPII vesicle coating (GO:0048208)5.38197824
6activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.12294099
7protein maturation by protein folding (GO:0022417)5.07142900
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.04117524
9positive regulation of nuclease activity (GO:0032075)4.90929992
10collagen fibril organization (GO:0030199)4.45860986
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.45329672
12regulation of nuclease activity (GO:0032069)4.43372905
13exocrine pancreas development (GO:0031017)4.35999380
14endoplasmic reticulum unfolded protein response (GO:0030968)4.32079872
15cellular response to vitamin D (GO:0071305)4.27873054
16cellular response to unfolded protein (GO:0034620)4.21591527
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.12751693
18cellular response to topologically incorrect protein (GO:0035967)4.11006604
19protein heterotrimerization (GO:0070208)4.09374278
20vesicle coating (GO:0006901)4.06289599
21keratan sulfate catabolic process (GO:0042340)4.04328121
22type B pancreatic cell development (GO:0003323)3.96934347
23glandular epithelial cell development (GO:0002068)3.96730640
24regulation of type B pancreatic cell apoptotic process (GO:2000674)3.96071970
25ER-nucleus signaling pathway (GO:0006984)3.91877392
26sequestering of metal ion (GO:0051238)3.90608483
27cellular response to vitamin (GO:0071295)3.79534628
28peptidyl-proline hydroxylation (GO:0019511)3.75765516
29endocrine pancreas development (GO:0031018)3.72911191
30skin morphogenesis (GO:0043589)3.70376181
31positive regulation of blood vessel endothelial cell migration (GO:0043536)3.69134724
32signal peptide processing (GO:0006465)3.56952267
33peptide hormone processing (GO:0016486)3.56898186
34adherens junction assembly (GO:0034333)3.49821326
35response to unfolded protein (GO:0006986)3.48076469
36protein hydroxylation (GO:0018126)3.44262327
37protein localization to endosome (GO:0036010)3.42631225
38cell-substrate junction assembly (GO:0007044)3.41539346
39response to endoplasmic reticulum stress (GO:0034976)3.41113927
40response to topologically incorrect protein (GO:0035966)3.38525253
41negative regulation of fatty acid transport (GO:2000192)3.33076793
42endodermal cell differentiation (GO:0035987)3.32026694
43focal adhesion assembly (GO:0048041)3.31529901
44cell-substrate adherens junction assembly (GO:0007045)3.31529901
45mannose metabolic process (GO:0006013)3.28687760
464-hydroxyproline metabolic process (GO:0019471)3.27758794
47cellular response to nutrient (GO:0031670)3.24550867
48regulation of extracellular matrix disassembly (GO:0010715)3.23877038
49apoptotic cell clearance (GO:0043277)3.23203439
50substrate-dependent cell migration (GO:0006929)3.21758210
51semaphorin-plexin signaling pathway (GO:0071526)3.20968870
52chondrocyte proliferation (GO:0035988)3.17668389
53basement membrane organization (GO:0071711)3.16732549
54regulation of early endosome to late endosome transport (GO:2000641)3.14170720
55Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.12662363
56ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.12360846
57positive regulation of extracellular matrix organization (GO:1903055)3.11119289
58glandular epithelial cell differentiation (GO:0002067)3.08542039
59bone trabecula formation (GO:0060346)3.07998725
60cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.07903208
61dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.07486965
62kidney mesenchyme development (GO:0072074)3.04945055
63polarized epithelial cell differentiation (GO:0030859)3.01797475
64protein N-linked glycosylation via asparagine (GO:0018279)2.99817715
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99337918
66peptidyl-asparagine modification (GO:0018196)2.98852935
67regulation of establishment of planar polarity (GO:0090175)2.98600433
68cell migration involved in heart development (GO:0060973)2.94798221
69sequestering of extracellular ligand from receptor (GO:0035581)2.94131215
70vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.93327657
71atrioventricular valve morphogenesis (GO:0003181)2.93032724
72collagen metabolic process (GO:0032963)2.91500722
73epithelial cell-cell adhesion (GO:0090136)2.91285430
74establishment of apical/basal cell polarity (GO:0035089)2.90602972
75regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.88547408
76endothelial cell morphogenesis (GO:0001886)2.87496632
77extracellular matrix assembly (GO:0085029)2.86915428
78barbed-end actin filament capping (GO:0051016)2.85723855
79columnar/cuboidal epithelial cell development (GO:0002066)2.85243672
80hypotonic response (GO:0006971)2.84220052
81vascular endothelial growth factor signaling pathway (GO:0038084)2.84050578
82collagen catabolic process (GO:0030574)2.83619749
83wound healing, spreading of epidermal cells (GO:0035313)2.81387497
84convergent extension (GO:0060026)2.80706726
85wound healing, spreading of cells (GO:0044319)2.79057906
86mesodermal cell differentiation (GO:0048333)2.77855841
87regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.77542633
88response to laminar fluid shear stress (GO:0034616)2.76734498
89negative regulation of cartilage development (GO:0061037)2.73817350
90positive regulation of hormone biosynthetic process (GO:0046886)2.73594344
91type B pancreatic cell proliferation (GO:0044342)2.73009863
92positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.72751771
93positive regulation of osteoblast proliferation (GO:0033690)2.72523803
94venous blood vessel morphogenesis (GO:0048845)2.72320539
95protein N-linked glycosylation (GO:0006487)2.71220637
96folic acid-containing compound biosynthetic process (GO:0009396)2.71217844
97cochlea morphogenesis (GO:0090103)2.70763948
98epithelial cell fate commitment (GO:0072148)2.70416093
99multicellular organismal macromolecule metabolic process (GO:0044259)2.66921772
100ER to Golgi vesicle-mediated transport (GO:0006888)2.66348796
101fibril organization (GO:0097435)2.65182620
102extracellular matrix disassembly (GO:0022617)2.64289963
103multicellular organismal catabolic process (GO:0044243)2.64247077
104positive regulation of epithelial to mesenchymal transition (GO:0010718)2.63022079
105cytoskeletal anchoring at plasma membrane (GO:0007016)2.62823027
106maintenance of protein localization in organelle (GO:0072595)2.62690042
107endothelial cell chemotaxis (GO:0035767)2.62475828
108embryo implantation (GO:0007566)2.61629571
109multicellular organismal metabolic process (GO:0044236)2.61083365
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.61057691
111cell migration involved in sprouting angiogenesis (GO:0002042)2.60889737
112regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60707557
113hemidesmosome assembly (GO:0031581)2.60533224
114chondroitin sulfate biosynthetic process (GO:0030206)2.59844622
115toxin metabolic process (GO:0009404)2.59757966
116nitric oxide mediated signal transduction (GO:0007263)2.58302369
117gland morphogenesis (GO:0022612)2.58038697
118positive regulation of receptor recycling (GO:0001921)2.57965622
119negative regulation of smooth muscle cell migration (GO:0014912)2.57814248
120metanephric mesenchyme development (GO:0072075)2.56522058
121endocardial cushion development (GO:0003197)2.56433671
122extracellular fibril organization (GO:0043206)2.56237797
123heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.55840190
124regulation of integrin-mediated signaling pathway (GO:2001044)2.55155142
125adhesion of symbiont to host (GO:0044406)2.54120608
126positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.53490840
127regulation of plasminogen activation (GO:0010755)2.53192399
128positive regulation of glycogen biosynthetic process (GO:0045725)2.52799113
129positive regulation of endothelial cell apoptotic process (GO:2000353)2.51495893
130positive regulation of p38MAPK cascade (GO:1900745)2.50674505
131paraxial mesoderm development (GO:0048339)2.50643202
132stress fiber assembly (GO:0043149)2.50069820
133regulation of extracellular matrix organization (GO:1903053)2.49479800
134maternal placenta development (GO:0001893)2.46761498
135cardiac myofibril assembly (GO:0055003)2.46718052
136membrane protein ectodomain proteolysis (GO:0006509)2.46360823
137blood vessel endothelial cell migration (GO:0043534)2.45672563
138hyaluronan catabolic process (GO:0030214)2.44709098
139extracellular matrix organization (GO:0030198)2.44113240
140Golgi organization (GO:0007030)2.43944667
141tooth mineralization (GO:0034505)2.43735173
142chondrocyte development (GO:0002063)2.42944480
143regulation of apoptotic process involved in morphogenesis (GO:1902337)2.39576211
144astrocyte differentiation (GO:0048708)2.38824959
145positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.38205480
146L-alpha-amino acid transmembrane transport (GO:1902475)2.37664838
147regulation of SMAD protein import into nucleus (GO:0060390)2.37542715
148cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.35327169
149negative regulation of glycoprotein biosynthetic process (GO:0010561)2.33873283
150negative regulation of chondrocyte differentiation (GO:0032331)2.33445511
151decidualization (GO:0046697)2.33435502
152cell adhesion mediated by integrin (GO:0033627)2.33254396
153positive regulation of insulin secretion (GO:0032024)2.33184320
154regulation of transforming growth factor beta2 production (GO:0032909)2.33144104
155positive regulation of SMAD protein import into nucleus (GO:0060391)2.33107727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.23493623
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.75817923
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.43447244
4CLOCK_20551151_ChIP-Seq_293T_Human3.12391910
5DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.93132540
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.83710885
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.81968954
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.80220689
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52445809
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.37222206
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36700593
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14185177
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.13238937
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06110689
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.00446273
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99201858
17* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93063811
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92305729
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86135326
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84320926
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83746557
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.82896382
23TFEB_21752829_ChIP-Seq_HELA_Human1.79145035
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76717549
25ATF3_27146783_Chip-Seq_COLON_Human1.76155870
26CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70183587
27VDR_21846776_ChIP-Seq_THP-1_Human1.69441738
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69309884
29ZNF263_19887448_ChIP-Seq_K562_Human1.65996475
30MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.64868168
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64596306
32FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.63906948
33ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.63067449
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61940711
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61870613
36TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.57980546
37BRD4_25478319_ChIP-Seq_HGPS_Human1.56035329
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.55276848
39TBX20_22328084_ChIP-Seq_HEART_Mouse1.55276848
40RACK7_27058665_Chip-Seq_MCF-7_Human1.55023950
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.54818755
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52231024
43MYC_22102868_ChIP-Seq_BL_Human1.51092291
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50448851
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48382596
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48362721
47UBF1/2_26484160_Chip-Seq_HMECs_Human1.47947021
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.47675386
49LXR_22292898_ChIP-Seq_THP-1_Human1.46223081
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44719526
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41913671
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40429785
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39953911
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39949563
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39394636
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35809545
57* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34280892
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32851614
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31518476
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.31105390
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29593322
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28479910
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.26549905
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.25947821
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24931664
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23961442
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23835005
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22984432
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22336379
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.20788497
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20749931
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20622619
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20263976
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19673797
75CJUN_26792858_Chip-Seq_BT549_Human1.19473547
76* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18623704
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18225626
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16956698
79SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16432298
80CREB1_26743006_Chip-Seq_LNCaP_Human1.14979555
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13131941
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.13117152
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.12767198
84TP53_22127205_ChIP-Seq_IMR90_Human1.12555604
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.10860066
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10329581
87SMC4_20622854_ChIP-Seq_HELA_Human1.09766340
88CHD1_26751641_Chip-Seq_LNCaP_Human1.09195793
89TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08847444
90EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07759493
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07220178
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.06357961
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06059893
94NCOR1_26117541_ChIP-Seq_K562_Human1.05595386
95KDM2B_26808549_Chip-Seq_DND41_Human1.05528603
96TP53_23651856_ChIP-Seq_MEFs_Mouse1.04478163
97* TCF7_22412390_ChIP-Seq_EML_Mouse1.04034146
98* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03191370
99* GABP_19822575_ChIP-Seq_HepG2_Human1.03130101
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03107302
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02721724
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02649067
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02522900
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02303531
105JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01746998
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01152076
107* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00396595
108GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00337149
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.98997644
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97713594
111PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97526131
112GABP_17652178_ChIP-ChIP_JURKAT_Human0.97202358
113* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96676041
114* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96052946
115* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95988409
116VDR_24763502_ChIP-Seq_THP-1_Human0.93848917
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93691744
118RXR_22158963_ChIP-Seq_LIVER_Mouse0.93678784
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93636019
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.93561529
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93033744
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92643957
123* P68_20966046_ChIP-Seq_HELA_Human0.92539370
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91532962
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91254079
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91193894
127GATA1_22025678_ChIP-Seq_K562_Human0.91120225
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89866811
129SOX2_20726797_ChIP-Seq_SW620_Human0.89671324
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89331558
131* KDM2B_26808549_Chip-Seq_K562_Human0.89021999
132* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88358445
133SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87273768
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87273768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.55770941
2MP0002877_abnormal_melanocyte_morpholog3.62986898
3MP0003283_abnormal_digestive_organ3.40928511
4MP0005503_abnormal_tendon_morphology3.32568572
5MP0003705_abnormal_hypodermis_morpholog3.06201466
6MP0005275_abnormal_skin_tensile3.04746000
7MP0003279_aneurysm2.82188248
8MP0000013_abnormal_adipose_tissue2.78112796
9MP0004272_abnormal_basement_membrane2.55987145
10MP0005257_abnormal_intraocular_pressure2.47825171
11MP0006054_spinal_hemorrhage2.34914650
12MP0000678_abnormal_parathyroid_gland2.05420784
13MP0003566_abnormal_cell_adhesion2.02730945
14MP0002896_abnormal_bone_mineralization1.89351935
15MP0002837_dystrophic_cardiac_calcinosis1.88483576
16MP0005508_abnormal_skeleton_morphology1.86473563
17MP0000003_abnormal_adipose_tissue1.84772706
18MP0003122_maternal_imprinting1.80472646
19MP0001944_abnormal_pancreas_morphology1.79302746
20MP0005220_abnormal_exocrine_pancreas1.75071312
21MP0009384_cardiac_valve_regurgitation1.71998605
22MP0009840_abnormal_foam_cell1.67078508
23MP0010368_abnormal_lymphatic_system1.59688222
24MP0001958_emphysema1.58818113
25MP0002693_abnormal_pancreas_physiology1.54551400
26MP0010030_abnormal_orbit_morphology1.53240747
27MP0009780_abnormal_chondrocyte_physiolo1.52902238
28MP0003123_paternal_imprinting1.50645711
29MP0005623_abnormal_meninges_morphology1.49328469
30MP0005023_abnormal_wound_healing1.47241351
31MP0002909_abnormal_adrenal_gland1.46275211
32MP0003300_gastrointestinal_ulcer1.41650963
33MP0004084_abnormal_cardiac_muscle1.40258589
34MP0010352_gastrointestinal_tract_polyps1.38060441
35MP0005409_darkened_coat_color1.36125752
36MP0005451_abnormal_body_composition1.33293567
37MP0000163_abnormal_cartilage_morphology1.30816519
38MP0001348_abnormal_lacrimal_gland1.30532656
39MP0002295_abnormal_pulmonary_circulatio1.28960622
40MP0003942_abnormal_urinary_system1.25645178
41MP0000428_abnormal_craniofacial_morphol1.24167583
42MP0003950_abnormal_plasma_membrane1.21979995
43MP0001915_intracranial_hemorrhage1.21815455
44MP0001270_distended_abdomen1.21758921
45MP0005076_abnormal_cell_differentiation1.21606804
46MP0001542_abnormal_bone_strength1.21479430
47MP0010386_abnormal_urinary_bladder1.20429942
48MP0002060_abnormal_skin_morphology1.19700637
49MP0002249_abnormal_larynx_morphology1.18536208
50MP0003091_abnormal_cell_migration1.17996289
51MP0002933_joint_inflammation1.16972732
52MP0000750_abnormal_muscle_regeneration1.14977803
53MP0000858_altered_metastatic_potential1.14588870
54MP0005390_skeleton_phenotype1.13416171
55MP0003195_calcinosis1.12870100
56MP0000767_abnormal_smooth_muscle1.09894057
57MP0009053_abnormal_anal_canal1.07119061
58MP0002234_abnormal_pharynx_morphology1.06308099
59MP0002254_reproductive_system_inflammat1.05849049
60MP0003795_abnormal_bone_structure1.05403241
61MP0004233_abnormal_muscle_weight1.05319330
62MP0004043_abnormal_pH_regulation1.04010063
63MP0000537_abnormal_urethra_morphology1.03964440
64MP0002115_abnormal_skeleton_extremities1.03963593
65MP0002108_abnormal_muscle_morphology1.03561238
66MP0000749_muscle_degeneration1.03067793
67MP0009250_abnormal_appendicular_skeleto1.02185863
68MP0003191_abnormal_cellular_cholesterol1.01551401
69MP0000462_abnormal_digestive_system1.00640163
70MP0008260_abnormal_autophagy1.00512363
71MP0003385_abnormal_body_wall0.98869477
72MP0001299_abnormal_eye_distance/0.98700062
73MP0001614_abnormal_blood_vessel0.97671851
74MP0001243_abnormal_dermal_layer0.97458754
75MP0005058_abnormal_lysosome_morphology0.96716076
76MP0002113_abnormal_skeleton_development0.96669174
77MP0000534_abnormal_ureter_morphology0.94506945
78MP0005375_adipose_tissue_phenotype0.93157231
79MP0003119_abnormal_digestive_system0.93014298
80MP0002928_abnormal_bile_duct0.92694975
81MP0000733_abnormal_muscle_development0.91720074
82MP0003453_abnormal_keratinocyte_physiol0.88618601
83MP0002932_abnormal_joint_morphology0.87067016
84MP0001849_ear_inflammation0.87062419
85MP0002269_muscular_atrophy0.87020579
86MP0000049_abnormal_middle_ear0.86333238
87MP0000762_abnormal_tongue_morphology0.86218190
88MP0004185_abnormal_adipocyte_glucose0.86079307
89MP0001879_abnormal_lymphatic_vessel0.85943974
90MP0005164_abnormal_response_to0.85647152
91MP0000432_abnormal_head_morphology0.85279395
92MP0003935_abnormal_craniofacial_develop0.82774773
93MP0003329_amyloid_beta_deposits0.82458217
94MP0002168_other_aberrant_phenotype0.81806260
95MP0005595_abnormal_vascular_smooth0.79581671
96MP0002116_abnormal_craniofacial_bone0.79526584
97MP0003941_abnormal_skin_development0.79209623
98MP0004264_abnormal_extraembryonic_tissu0.78870695
99MP0003115_abnormal_respiratory_system0.78833700
100MP0002282_abnormal_trachea_morphology0.78773476
101MP0003045_fibrosis0.78092026
102MP0004036_abnormal_muscle_relaxation0.77693136
103MP0002653_abnormal_ependyma_morphology0.77504408
104MP0002078_abnormal_glucose_homeostasis0.77503709
105MP0005197_abnormal_uvea_morphology0.77480401
106MP0002925_abnormal_cardiovascular_devel0.76719542
107MP0004134_abnormal_chest_morphology0.76451535
108MP0006138_congestive_heart_failure0.76178313
109MP0000751_myopathy0.75673048
110MP0001533_abnormal_skeleton_physiology0.74952506
111MP0005621_abnormal_cell_physiology0.74548430
112MP0002998_abnormal_bone_remodeling0.74466009
113MP0000266_abnormal_heart_morphology0.73456870
114MP0003436_decreased_susceptibility_to0.72380652
115MP0002089_abnormal_postnatal_growth/wei0.71834675
116MP0009278_abnormal_bone_marrow0.71248178
117MP0005379_endocrine/exocrine_gland_phen0.71226646
118MP0004087_abnormal_muscle_fiber0.71185551
119MP0002092_abnormal_eye_morphology0.71134075
120MP0002128_abnormal_blood_circulation0.70784489
121MP0001175_abnormal_lung_morphology0.70618031
122MP0003448_altered_tumor_morphology0.69055186
123MP0002109_abnormal_limb_morphology0.68985384
124MP0000759_abnormal_skeletal_muscle0.68913217
125MP0003755_abnormal_palate_morphology0.68776261
126MP0002111_abnormal_tail_morphology0.68066312
127MP0003121_genomic_imprinting0.67512329
128MP0010630_abnormal_cardiac_muscle0.67506961
129MP0003172_abnormal_lysosome_physiology0.66708815
130MP0004858_abnormal_nervous_system0.66626593
131MP0004510_myositis0.63499780
132MP0002114_abnormal_axial_skeleton0.63481575

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.59146145
2Premature rupture of membranes (HP:0001788)5.95583791
3Cervical subluxation (HP:0003308)4.06371018
4Cerebral aneurysm (HP:0004944)3.89206439
5Hyperinsulinemic hypoglycemia (HP:0000825)3.78877216
6Aortic dissection (HP:0002647)3.61785765
7Soft skin (HP:0000977)3.61678668
8Ankle contracture (HP:0006466)3.58131284
9Abnormality of dentin (HP:0010299)3.51633627
10Vertebral compression fractures (HP:0002953)3.31273943
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.28408253
12Hypoglycemic seizures (HP:0002173)3.24428274
13Bladder diverticulum (HP:0000015)3.15814553
14Shallow orbits (HP:0000586)3.14169071
15Peritonitis (HP:0002586)3.14078410
16Aortic aneurysm (HP:0004942)3.09360570
17Hypoglycemic coma (HP:0001325)3.07866988
18Abnormal pancreas size (HP:0012094)3.03742867
19Atrophic scars (HP:0001075)2.91413436
20Ulnar bowing (HP:0003031)2.87929408
21Insulin-resistant diabetes mellitus (HP:0000831)2.87403623
22Symptomatic seizures (HP:0011145)2.83936599
23Disproportionate tall stature (HP:0001519)2.79572209
24Hyperglycemia (HP:0003074)2.77075748
25Blue sclerae (HP:0000592)2.75588465
26Mitral regurgitation (HP:0001653)2.75200007
27Large for gestational age (HP:0001520)2.71727029
28Thoracolumbar scoliosis (HP:0002944)2.69719151
29Dilatation of the ascending aorta (HP:0005111)2.67075269
30Hepatoblastoma (HP:0002884)2.66140836
31Wormian bones (HP:0002645)2.64217088
32Fragile skin (HP:0001030)2.63781935
33Aneurysm (HP:0002617)2.60917766
34Neonatal short-limb short stature (HP:0008921)2.60265373
35Abnormality of the acetabulum (HP:0003170)2.59961043
36Broad face (HP:0000283)2.51775005
37Spinal rigidity (HP:0003306)2.51432558
38Broad metatarsal (HP:0001783)2.45211503
39Genu recurvatum (HP:0002816)2.44893683
40Slender build (HP:0001533)2.41640083
41Mucopolysacchariduria (HP:0008155)2.41334746
42Urinary glycosaminoglycan excretion (HP:0003541)2.41334746
43Mildly elevated creatine phosphokinase (HP:0008180)2.39869706
44Hyperacusis (HP:0010780)2.39504090
45Hand muscle atrophy (HP:0009130)2.39273447
46Aortic regurgitation (HP:0001659)2.38693951
47Short nail (HP:0001799)2.38661478
48Platyspondyly (HP:0000926)2.38104341
49Biconcave vertebral bodies (HP:0004586)2.37348751
50Type 1 muscle fiber predominance (HP:0003803)2.37022919
51Abnormality of endocrine pancreas physiology (HP:0012093)2.36981114
52Abnormality of the pancreatic islet cells (HP:0006476)2.36981114
53Obstructive sleep apnea (HP:0002870)2.36357204
54Vascular tortuosity (HP:0004948)2.34585629
55Spondylolisthesis (HP:0003302)2.33649739
56Thin bony cortex (HP:0002753)2.32581894
57Mitral valve prolapse (HP:0001634)2.29656897
58Overgrowth (HP:0001548)2.29516222
59Achilles tendon contracture (HP:0001771)2.27925229
60Pancreatic islet-cell hyperplasia (HP:0004510)2.23209882
61Elbow flexion contracture (HP:0002987)2.22431676
62Hyperextensible skin (HP:0000974)2.22004046
63Arterial tortuosity (HP:0005116)2.19232674
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19061090
65Abnormality of polysaccharide metabolism (HP:0011012)2.19061090
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19061090
67Distal upper limb amyotrophy (HP:0007149)2.16321005
68Upper limb amyotrophy (HP:0009129)2.16321005
69Dysostosis multiplex (HP:0000943)2.13524448
70Osteoarthritis (HP:0002758)2.11628446
71Follicular hyperkeratosis (HP:0007502)2.11015367
72Beaking of vertebral bodies (HP:0004568)2.10624947
73Abnormality of skeletal muscle fiber size (HP:0012084)2.10154852
74Joint laxity (HP:0001388)2.09229664
75Insulin resistance (HP:0000855)2.09122994
76Increased connective tissue (HP:0009025)2.09121521
77Ketoacidosis (HP:0001993)2.07549965
78Long toe (HP:0010511)2.07345411
79Abnormal delivery (HP:0001787)2.07078863
80Abnormality of the Achilles tendon (HP:0005109)2.06657283
81Distal lower limb amyotrophy (HP:0008944)2.06164797
82Congenital glaucoma (HP:0001087)2.05235774
83Wide anterior fontanel (HP:0000260)2.05041790
84Metaphyseal cupping (HP:0003021)2.04739120
85Hypoplastic ischia (HP:0003175)2.04583036
86Hypoventilation (HP:0002791)2.04228292
87Joint stiffness (HP:0001387)2.03651401
88Epiphyseal dysplasia (HP:0002656)2.03220027
89Abnormality of calcium-phosphate metabolism (HP:0100530)2.01164131
90Coxa vara (HP:0002812)1.99326222
91Turricephaly (HP:0000262)1.98973166
92Exostoses (HP:0100777)1.98924530
93Atelectasis (HP:0100750)1.97713892
94Flat acetabular roof (HP:0003180)1.97294239
95Slender long bone (HP:0003100)1.96149938
96Ectopia lentis (HP:0001083)1.95873668
97Spinal cord lesions (HP:0100561)1.94303187
98Syringomyelia (HP:0003396)1.94303187
99Bowel diverticulosis (HP:0005222)1.94247176
100Premature skin wrinkling (HP:0100678)1.93600316
101Inguinal hernia (HP:0000023)1.92176228
102Missing ribs (HP:0000921)1.91856864
103Late onset (HP:0003584)1.91686882
104Camptodactyly of toe (HP:0001836)1.91357131
105Abnormality of the distal phalanges of the toes (HP:0010182)1.87913914
106Striae distensae (HP:0001065)1.87063040
107Mitral stenosis (HP:0001718)1.86994707
108Broad long bones (HP:0005622)1.86384376
109Nonimmune hydrops fetalis (HP:0001790)1.86315441
110Flat capital femoral epiphysis (HP:0003370)1.85803162
111Natal tooth (HP:0000695)1.85077355
112Breech presentation (HP:0001623)1.84045619
113Renal duplication (HP:0000075)1.83488400
114Thin ribs (HP:0000883)1.83007927
115Osteolytic defects of the hand bones (HP:0009699)1.82777279
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.82777279
117Ovoid vertebral bodies (HP:0003300)1.82602917
118Long palpebral fissure (HP:0000637)1.82038478
119Generalized amyotrophy (HP:0003700)1.81125320
120Asymmetric septal hypertrophy (HP:0001670)1.79660052
121Absent frontal sinuses (HP:0002688)1.78723471
122Osteopenia (HP:0000938)1.78595914
123Spinal cord compression (HP:0002176)1.77840576
124Mesomelia (HP:0003027)1.77436974
125Wrist flexion contracture (HP:0001239)1.76912203
126Hypoplasia of the odontoid process (HP:0003311)1.76745884
127Difficulty climbing stairs (HP:0003551)1.76485473
128Abnormality of the ischium (HP:0003174)1.76451014
129Coronal craniosynostosis (HP:0004440)1.76355104
130Arnold-Chiari malformation (HP:0002308)1.76346979
131Bowed forearm bones (HP:0003956)1.75990841
132Bowing of the arm (HP:0006488)1.75990841
133Hyperparathyroidism (HP:0000843)1.74532420
134Hypercortisolism (HP:0001578)1.74027476
135Radial bowing (HP:0002986)1.73056315
136Dislocated radial head (HP:0003083)1.73027427
137Cupped ribs (HP:0000887)1.72581989
138Increased variability in muscle fiber diameter (HP:0003557)1.72158698
139Arachnodactyly (HP:0001166)1.71489385
140Stridor (HP:0010307)1.71335379
141Abnormal ossification of hand bones (HP:0005921)1.71047034
142Aortic valve stenosis (HP:0001650)1.70458348
143Round ear (HP:0100830)1.69398743
144Venous abnormality (HP:0002624)1.69247541
145Mild short stature (HP:0003502)1.64982302
146Abnormality of skull ossification (HP:0002703)1.64340328
147Vertebral arch anomaly (HP:0008438)1.63941236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.14845999
2ERN14.03779912
3PASK3.93974978
4INSRR3.21289378
5PKN22.96205858
6PDGFRA2.88669260
7MAPK152.74750565
8FLT32.55132836
9ICK2.52325129
10SMG12.32181633
11DDR22.31772601
12LATS12.25044271
13PRPF4B2.22994647
14PRKD32.20512256
15TTN2.15728857
16RIPK12.02884890
17PTK21.80802538
18EPHA31.74013017
19LATS21.71826740
20HIPK21.70568315
21SIK11.70061543
22PTK61.67097225
23BRSK21.61779206
24TESK11.58565039
25STK31.52492111
26MAP2K31.47567276
27PAK41.33306835
28MAP3K31.32996125
29STK38L1.28230089
30TAOK31.28056142
31EPHA21.27775179
32MET1.25186541
33MARK21.23020493
34STK381.20489811
35MAP3K101.16596449
36PAK31.14153233
37NTRK11.10888867
38RPS6KA41.10704857
39KSR21.10431099
40SCYL21.09657688
41PIM21.06360576
42PAK21.05757097
43TYRO31.03834562
44MAP3K61.03371205
45MAP3K71.02723481
46CDC42BPA1.02352957
47MAP3K131.02164104
48DYRK1B1.01102008
49TAOK20.99694564
50MTOR0.99474088
51PRKG20.99291947
52DMPK0.97370860
53FER0.94994187
54LRRK20.94491508
55JAK30.91735908
56NEK90.91094752
57ILK0.89138379
58TGFBR20.89031670
59ARAF0.87876533
60MST1R0.87578060
61MYLK0.86526778
62CDK80.81793125
63LMTK20.78998066
64WNK40.76569460
65EPHB20.76189704
66MAP2K20.75198109
67MAPKAPK30.74222591
68PDPK10.71281431
69WNK10.69340733
70PDGFRB0.69156573
71PIK3CG0.66525546
72CAMKK20.65796435
73CDK120.65379655
74MAP3K10.65113712
75TRPM70.64888403
76ROCK20.63781207
77FGFR30.63211584
78KDR0.62654290
79DYRK30.61256820
80STK100.61178281
81PRKD20.60593753
82LIMK10.60592958
83BCKDK0.60472492
84BRSK10.59938028
85RPS6KC10.58287377
86RPS6KL10.58287377
87ERBB40.57828890
88ZAP700.57427979
89CHUK0.57231141
90NLK0.56670263
91TIE10.55497676
92MOS0.54880985
93EIF2AK30.54505809
94EPHB10.53959953
95TYK20.53504977
96BRD40.53465499
97MAPK70.53133540
98ERBB30.51681351
99PRKCI0.51641066
100TGFBR10.51351992
101CLK10.51131421
102TBK10.48666940
103MELK0.48641591
104SIK20.48620656
105PRKCH0.47471027
106AKT30.45643547
107CDK90.44900177
108ROCK10.44869203
109MAP2K10.44163620
110IRAK10.43249097
111FGFR10.42584508
112MAPKAPK20.41347430
113MAP3K80.41194904
114PAK10.41168555
115EEF2K0.41025414
116PRKD10.40566325
117IRAK30.40521175
118TAOK10.39769799
119FGFR40.39461212
120BRAF0.39280222
121BMX0.39153791
122STK240.38931447
123PTK2B0.38914518
124FRK0.38845794
125KSR10.37815503
126RPS6KA20.36949034
127RET0.36450035
128CDK70.35078867
129CAMK1G0.33883263
130MAPK110.33566699
131RPS6KA60.33325374
132MAP3K110.33307940
133GSK3A0.33135273
134MAP3K20.32904448
135WNK30.32692383
136JAK10.32677253

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.75591615
2Protein export_Homo sapiens_hsa030604.19487228
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.62123123
4ECM-receptor interaction_Homo sapiens_hsa045122.41328612
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.29077953
6N-Glycan biosynthesis_Homo sapiens_hsa005102.09334659
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.05770716
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99204076
9Protein digestion and absorption_Homo sapiens_hsa049741.85214591
10Focal adhesion_Homo sapiens_hsa045101.85147435
11Other glycan degradation_Homo sapiens_hsa005111.83722635
12Lysosome_Homo sapiens_hsa041421.74691905
13Vibrio cholerae infection_Homo sapiens_hsa051101.69951294
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57948545
15Bladder cancer_Homo sapiens_hsa052191.55716312
16Selenocompound metabolism_Homo sapiens_hsa004501.46943673
17Sulfur metabolism_Homo sapiens_hsa009201.46688584
18Galactose metabolism_Homo sapiens_hsa000521.41062549
19Insulin secretion_Homo sapiens_hsa049111.40512015
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37499728
21VEGF signaling pathway_Homo sapiens_hsa043701.35775822
22Non-small cell lung cancer_Homo sapiens_hsa052231.35155514
23Dilated cardiomyopathy_Homo sapiens_hsa054141.32970837
24Proteoglycans in cancer_Homo sapiens_hsa052051.27445863
25Amoebiasis_Homo sapiens_hsa051461.26207513
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22909259
27Adherens junction_Homo sapiens_hsa045201.22417303
28Insulin resistance_Homo sapiens_hsa049311.19139796
29Chronic myeloid leukemia_Homo sapiens_hsa052201.17553476
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16779410
31Small cell lung cancer_Homo sapiens_hsa052221.16607926
32Hippo signaling pathway_Homo sapiens_hsa043901.14950548
33Glioma_Homo sapiens_hsa052141.13636799
34TGF-beta signaling pathway_Homo sapiens_hsa043501.11417036
35Type II diabetes mellitus_Homo sapiens_hsa049301.10203334
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06461737
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.05436553
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05156701
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03988917
40ErbB signaling pathway_Homo sapiens_hsa040121.03164121
41Hedgehog signaling pathway_Homo sapiens_hsa043401.01168954
42p53 signaling pathway_Homo sapiens_hsa041150.96128501
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92818799
44Thyroid cancer_Homo sapiens_hsa052160.92234548
45Choline metabolism in cancer_Homo sapiens_hsa052310.91403161
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91218639
47Axon guidance_Homo sapiens_hsa043600.90844959
48Legionellosis_Homo sapiens_hsa051340.90438252
49MicroRNAs in cancer_Homo sapiens_hsa052060.88806588
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88585783
51* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86721387
52Complement and coagulation cascades_Homo sapiens_hsa046100.85665469
53Melanogenesis_Homo sapiens_hsa049160.85620080
54Rap1 signaling pathway_Homo sapiens_hsa040150.84815567
55GnRH signaling pathway_Homo sapiens_hsa049120.84742815
56Basal cell carcinoma_Homo sapiens_hsa052170.84369277
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84145679
58Malaria_Homo sapiens_hsa051440.83999250
59Endocytosis_Homo sapiens_hsa041440.83805519
60Cell cycle_Homo sapiens_hsa041100.83710564
61Prolactin signaling pathway_Homo sapiens_hsa049170.83526637
62Prostate cancer_Homo sapiens_hsa052150.83447746
63Fructose and mannose metabolism_Homo sapiens_hsa000510.83414881
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82927085
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82176672
66Pancreatic cancer_Homo sapiens_hsa052120.80772505
67HTLV-I infection_Homo sapiens_hsa051660.80643699
68Glucagon signaling pathway_Homo sapiens_hsa049220.79424743
69Hepatitis C_Homo sapiens_hsa051600.79354832
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.78734119
71Pentose phosphate pathway_Homo sapiens_hsa000300.78712674
72Thyroid hormone synthesis_Homo sapiens_hsa049180.77074502
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76795919
74Type I diabetes mellitus_Homo sapiens_hsa049400.76447333
75Tight junction_Homo sapiens_hsa045300.75653495
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75351324
77mTOR signaling pathway_Homo sapiens_hsa041500.72403317
78Toxoplasmosis_Homo sapiens_hsa051450.71721907
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70525191
80Viral carcinogenesis_Homo sapiens_hsa052030.70512140
81Salmonella infection_Homo sapiens_hsa051320.69351476
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.67574209
83TNF signaling pathway_Homo sapiens_hsa046680.66706557
84Circadian rhythm_Homo sapiens_hsa047100.66582200
85Phagosome_Homo sapiens_hsa041450.66025440
86Lysine degradation_Homo sapiens_hsa003100.65859445
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65580732
88Notch signaling pathway_Homo sapiens_hsa043300.65168174
89Osteoclast differentiation_Homo sapiens_hsa043800.62798746
90Gap junction_Homo sapiens_hsa045400.61695729
91Apoptosis_Homo sapiens_hsa042100.59923321
92Pathways in cancer_Homo sapiens_hsa052000.59717086
93Folate biosynthesis_Homo sapiens_hsa007900.59334875
94Inositol phosphate metabolism_Homo sapiens_hsa005620.57741596
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56915154
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56852507
97MAPK signaling pathway_Homo sapiens_hsa040100.56565340
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56557893
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56380374
100Antigen processing and presentation_Homo sapiens_hsa046120.55884999
101Insulin signaling pathway_Homo sapiens_hsa049100.55363579
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54447079
103Melanoma_Homo sapiens_hsa052180.54208529
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.53198804
105Ovarian steroidogenesis_Homo sapiens_hsa049130.53122764
106Estrogen signaling pathway_Homo sapiens_hsa049150.51775785
107Platelet activation_Homo sapiens_hsa046110.51568257
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.49537748
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49234378
110AMPK signaling pathway_Homo sapiens_hsa041520.48647158
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.48577706
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48548304
113Acute myeloid leukemia_Homo sapiens_hsa052210.48519322
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48114979
115Colorectal cancer_Homo sapiens_hsa052100.48012512
116Prion diseases_Homo sapiens_hsa050200.47789000
117FoxO signaling pathway_Homo sapiens_hsa040680.47771707
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47473251
119Renal cell carcinoma_Homo sapiens_hsa052110.47342897
120Hepatitis B_Homo sapiens_hsa051610.46831522
121Cocaine addiction_Homo sapiens_hsa050300.46183075
122Endometrial cancer_Homo sapiens_hsa052130.46121571
123Wnt signaling pathway_Homo sapiens_hsa043100.45910321
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45571848
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.45376649
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42187672
127HIF-1 signaling pathway_Homo sapiens_hsa040660.41448865
128Viral myocarditis_Homo sapiens_hsa054160.41233596
129Shigellosis_Homo sapiens_hsa051310.39297106
130Sphingolipid metabolism_Homo sapiens_hsa006000.38814145

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