POGK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.79313298
2nuclear pore organization (GO:0006999)5.81848584
3pore complex assembly (GO:0046931)5.01196938
4fat-soluble vitamin catabolic process (GO:0042363)4.55763036
5vitamin catabolic process (GO:0009111)4.55763036
6neuron cell-cell adhesion (GO:0007158)4.53524997
7regulation of NFAT protein import into nucleus (GO:0051532)4.52128073
8axonal fasciculation (GO:0007413)4.25238456
9vocalization behavior (GO:0071625)4.18844571
10glial cell proliferation (GO:0014009)4.13134205
11dendrite morphogenesis (GO:0048813)4.11511184
12DNA unwinding involved in DNA replication (GO:0006268)4.07545381
13layer formation in cerebral cortex (GO:0021819)3.99593810
14regulation of centriole replication (GO:0046599)3.99080924
15central nervous system projection neuron axonogenesis (GO:0021952)3.95274129
16pre-miRNA processing (GO:0031054)3.94010064
17cell migration in hindbrain (GO:0021535)3.90159070
18cerebral cortex radially oriented cell migration (GO:0021799)3.88890606
19neuron recognition (GO:0008038)3.86685225
20dendritic spine morphogenesis (GO:0060997)3.81041964
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.80696118
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.77464036
23locomotory exploration behavior (GO:0035641)3.71431203
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.68277909
25synaptic vesicle maturation (GO:0016188)3.64940705
26limb bud formation (GO:0060174)3.59408019
27postsynaptic membrane organization (GO:0001941)3.58389830
28regulation of translational fidelity (GO:0006450)3.46899442
29regulation of RNA export from nucleus (GO:0046831)3.41315877
30nerve growth factor signaling pathway (GO:0038180)3.41010048
31spliceosomal tri-snRNP complex assembly (GO:0000244)3.41000728
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.39146116
33regulation of synaptic vesicle exocytosis (GO:2000300)3.38584765
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.36304594
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34159361
36regulation of synapse structural plasticity (GO:0051823)3.33898173
37regulation of glutamate receptor signaling pathway (GO:1900449)3.33628139
38presynaptic membrane assembly (GO:0097105)3.33283642
39protein localization to synapse (GO:0035418)3.25776292
40glucocorticoid receptor signaling pathway (GO:0042921)3.25384547
41positive regulation of cell cycle checkpoint (GO:1901978)3.23864317
42regulation of nucleobase-containing compound transport (GO:0032239)3.19981531
43central nervous system neuron axonogenesis (GO:0021955)3.19950356
44cytoplasmic mRNA processing body assembly (GO:0033962)3.19090439
45presynaptic membrane organization (GO:0097090)3.17703839
46regulation of centrosome duplication (GO:0010824)3.16621913
47pyrimidine nucleobase catabolic process (GO:0006208)3.14580393
48DNA duplex unwinding (GO:0032508)3.13740680
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12275380
50protein export from nucleus (GO:0006611)3.06775988
51ectodermal placode formation (GO:0060788)3.04228328
52DNA geometric change (GO:0032392)3.01992116
53synaptic vesicle docking involved in exocytosis (GO:0016081)2.97835584
54peptidyl-lysine dimethylation (GO:0018027)2.96949778
55synaptic transmission, glutamatergic (GO:0035249)2.96573824
56dosage compensation (GO:0007549)2.96061945
57cellular protein complex localization (GO:0034629)2.95027542
58embryonic camera-type eye morphogenesis (GO:0048596)2.93788262
59protein localization to endosome (GO:0036010)2.93562563
60cerebellar Purkinje cell differentiation (GO:0021702)2.90448735
61cranial suture morphogenesis (GO:0060363)2.89708243
62histone H2B ubiquitination (GO:0033523)2.87825798
63cerebellar granule cell differentiation (GO:0021707)2.87080024
64mitotic chromosome condensation (GO:0007076)2.86808400
65exploration behavior (GO:0035640)2.85791406
66activation of Rac GTPase activity (GO:0032863)2.83849559
67synaptic vesicle exocytosis (GO:0016079)2.82723861
68regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82371243
69glutamate receptor signaling pathway (GO:0007215)2.82203992
70positive regulation of synapse assembly (GO:0051965)2.80885434
71regulation of centrosome cycle (GO:0046605)2.80813907
72prepulse inhibition (GO:0060134)2.80602815
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.80154922
74establishment of nucleus localization (GO:0040023)2.80135214
75synaptic vesicle endocytosis (GO:0048488)2.80101497
76sister chromatid segregation (GO:0000819)2.79569365
77nucleosome disassembly (GO:0006337)2.79542026
78protein-DNA complex disassembly (GO:0032986)2.79542026
79regulation of synaptic vesicle transport (GO:1902803)2.78601972
80regulation of neuronal synaptic plasticity (GO:0048168)2.77037441
81glutamate secretion (GO:0014047)2.74809395
82regulation of axon extension involved in axon guidance (GO:0048841)2.74460773
83protein complex localization (GO:0031503)2.73805138
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72933958
85RNA stabilization (GO:0043489)2.71731204
86mRNA stabilization (GO:0048255)2.71731204
87axonogenesis (GO:0007409)2.70564776
88axon extension (GO:0048675)2.70107404
89regulation of dendritic spine morphogenesis (GO:0061001)2.69240821
90cranial nerve morphogenesis (GO:0021602)2.68766026
91neurotransmitter secretion (GO:0007269)2.68407193
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.68314687
93synapse assembly (GO:0007416)2.68039708
94craniofacial suture morphogenesis (GO:0097094)2.67517366
95regulation of axon guidance (GO:1902667)2.66804063
96regulation of mammary gland epithelial cell proliferation (GO:0033599)2.65996402
97sister chromatid cohesion (GO:0007062)2.65409450
98neuron projection morphogenesis (GO:0048812)2.65095424
99protein localization to chromosome, centromeric region (GO:0071459)2.64600564
100neuron-neuron synaptic transmission (GO:0007270)2.63853342
101regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63699749
102hippocampus development (GO:0021766)2.61949990
103regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61820922
104auditory behavior (GO:0031223)2.61801004
105adult walking behavior (GO:0007628)2.61702381
106response to pheromone (GO:0019236)2.61349864
107cornea development in camera-type eye (GO:0061303)2.60652008
108negative regulation of axon extension involved in axon guidance (GO:0048843)2.59723069
109organelle transport along microtubule (GO:0072384)2.59499819
110negative regulation of axon extension (GO:0030517)2.59355632
111regulation of respiratory system process (GO:0044065)2.58974403
112regulation of sister chromatid cohesion (GO:0007063)2.58728287
113proximal/distal pattern formation (GO:0009954)2.57407596
114innervation (GO:0060384)2.57376622
115positive regulation of synapse maturation (GO:0090129)2.57083752
116axon ensheathment in central nervous system (GO:0032291)2.57060302
117central nervous system myelination (GO:0022010)2.57060302
118neuronal ion channel clustering (GO:0045161)2.56456785
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56064573
120neuronal action potential propagation (GO:0019227)2.56023997
121gamma-aminobutyric acid transport (GO:0015812)2.55834039
122negative regulation of axonogenesis (GO:0050771)2.54669122
123membrane hyperpolarization (GO:0060081)2.54427229
124establishment of mitochondrion localization (GO:0051654)2.53860363
125mitotic sister chromatid segregation (GO:0000070)2.52880831
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.52814653
127positive regulation of RNA splicing (GO:0033120)2.52517904
128embryonic eye morphogenesis (GO:0048048)2.52025695
129DNA topological change (GO:0006265)2.51664737
130regulation of chromatin binding (GO:0035561)2.51094360
131DNA synthesis involved in DNA repair (GO:0000731)2.50924738
132negative regulation of axon guidance (GO:1902668)2.50569555
133NLS-bearing protein import into nucleus (GO:0006607)2.50363976
134regulation of excitatory postsynaptic membrane potential (GO:0060079)2.50328857
135regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.49902673
136asymmetric protein localization (GO:0008105)2.48590545
137membrane disassembly (GO:0030397)2.46999797
138nuclear envelope disassembly (GO:0051081)2.46999797
139clathrin coat assembly (GO:0048268)2.46475112
140regulation of synapse assembly (GO:0051963)2.46001716
141regulation of histone H3-K27 methylation (GO:0061085)2.45550529
142COPI coating of Golgi vesicle (GO:0048205)2.44793780
143Golgi transport vesicle coating (GO:0048200)2.44793780
144mitotic nuclear envelope disassembly (GO:0007077)2.44149839
145negative regulation of oligodendrocyte differentiation (GO:0048715)2.43971714
146corticosteroid receptor signaling pathway (GO:0031958)2.43860120
147vesicle transport along microtubule (GO:0047496)2.42499665
148spinal cord development (GO:0021510)2.42178291
149histone H3-K36 demethylation (GO:0070544)2.42076854
150cerebellum development (GO:0021549)2.41719853
151mechanosensory behavior (GO:0007638)2.41630793
152apical protein localization (GO:0045176)2.41108564
153morphogenesis of an epithelial sheet (GO:0002011)2.40991418
154peptidyl-arginine omega-N-methylation (GO:0035247)2.40494899
155snRNA metabolic process (GO:0016073)2.39947094
156mRNA transport (GO:0051028)2.39157004
157synapse organization (GO:0050808)2.38679131
158regulation of postsynaptic membrane potential (GO:0060078)2.37838092
159lens fiber cell development (GO:0070307)2.37799082
160glycine transport (GO:0015816)2.37364423
161histone H3-K4 trimethylation (GO:0080182)2.37357064
162neuron projection extension (GO:1990138)2.37236787
163protein retention in ER lumen (GO:0006621)2.37210865
164non-recombinational repair (GO:0000726)2.37172250
165double-strand break repair via nonhomologous end joining (GO:0006303)2.37172250
166negative regulation of histone methylation (GO:0031061)2.37128672
167peptidyl-arginine N-methylation (GO:0035246)2.37085273
168peptidyl-arginine methylation (GO:0018216)2.37085273
169positive regulation of membrane potential (GO:0045838)2.36971564
170neuromuscular process controlling balance (GO:0050885)2.36800268
171histone H4-K16 acetylation (GO:0043984)2.36505289
172mitotic sister chromatid cohesion (GO:0007064)2.36235304
173semaphorin-plexin signaling pathway (GO:0071526)2.35759391
174maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.35285724
175intracellular estrogen receptor signaling pathway (GO:0030520)2.33770040
176nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.32007298
177peptidyl-threonine modification (GO:0018210)2.31947619
178embryonic body morphogenesis (GO:0010172)2.31618936
179monoubiquitinated protein deubiquitination (GO:0035520)2.31595455
180protein localization to microtubule (GO:0035372)2.30998435
181negative regulation of mRNA metabolic process (GO:1903312)2.30194936
182adherens junction assembly (GO:0034333)2.29981172
183positive regulation of keratinocyte differentiation (GO:0045618)2.29818191
184peptidyl-threonine phosphorylation (GO:0018107)2.29733352
185nuclear envelope organization (GO:0006998)2.29686348
186stress granule assembly (GO:0034063)2.29596123
187hippo signaling (GO:0035329)2.28874009
188amino acid import (GO:0043090)2.28599845
189DNA conformation change (GO:0071103)2.27984567
190negative regulation of mRNA processing (GO:0050686)2.27600822
191epithelial cell differentiation involved in prostate gland development (GO:0060742)2.27435985
192positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.27001323
193regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.27001323
194body morphogenesis (GO:0010171)2.25253250
195nucleus organization (GO:0006997)2.24930352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.65126335
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.75082635
3EZH2_22144423_ChIP-Seq_EOC_Human4.62903921
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.50328778
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23370435
6MYC_22102868_ChIP-Seq_BL_Human3.12212930
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.88430650
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82975455
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69040905
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67774627
11GBX2_23144817_ChIP-Seq_PC3_Human2.65401262
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61083992
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61083992
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.58250899
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56169834
16CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.42943253
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41944141
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32957320
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31829521
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.31002245
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30388652
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.24709700
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23985978
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23804846
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.20953189
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.20781691
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10940672
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09251254
29PKCTHETA_26484144_Chip-Seq_BREAST_Human2.07727112
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.06609863
31DROSHA_22980978_ChIP-Seq_HELA_Human2.06588339
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00775573
33AR_21572438_ChIP-Seq_LNCaP_Human1.98843137
34AR_21909140_ChIP-Seq_LNCAP_Human1.91125800
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.87870935
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87414091
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84456428
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84083490
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82199980
40* CHD1_26751641_Chip-Seq_LNCaP_Human1.82047686
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81699085
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80719375
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78550060
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78200424
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.77206991
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76406655
47* RARB_27405468_Chip-Seq_BRAIN_Mouse1.76162234
48REST_21632747_ChIP-Seq_MESCs_Mouse1.75336045
49IGF1R_20145208_ChIP-Seq_DFB_Human1.75071360
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.73773907
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.73555107
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73011177
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.72496470
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72353074
55KDM5A_27292631_Chip-Seq_BREAST_Human1.71037797
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70105419
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68546416
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67851558
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66788000
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65025093
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63240211
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62895541
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.62677408
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60704843
65* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59029920
66XRN2_22483619_ChIP-Seq_HELA_Human1.58863955
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58615210
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57709635
69VDR_21846776_ChIP-Seq_THP-1_Human1.57172854
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.57085970
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55250485
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52469811
73TCF7_22412390_ChIP-Seq_EML_Mouse1.51628759
74SMAD4_21799915_ChIP-Seq_A2780_Human1.50895669
75CLOCK_20551151_ChIP-Seq_293T_Human1.49170879
76* RING1B_27294783_Chip-Seq_NPCs_Mouse1.48194187
77* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48040357
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47372444
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46309562
80FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.45495956
81TAF15_26573619_Chip-Seq_HEK293_Human1.44745073
82* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44337256
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.42765007
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42301365
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42226809
86* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40384703
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40297963
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39998685
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.39553023
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38962250
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38158621
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35122413
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.35080307
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32828293
95AHR_22903824_ChIP-Seq_MCF-7_Human1.32676231
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.32527972
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32333672
98* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31303128
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.31251178
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31143594
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.30983334
102P300_19829295_ChIP-Seq_ESCs_Human1.30464204
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29776366
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29230207
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28527929
106* REST_18959480_ChIP-ChIP_MESCs_Mouse1.27951663
107MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27858781
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27286387
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.26631785
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26329034
111* RACK7_27058665_Chip-Seq_MCF-7_Human1.26112553
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25955235
113* KDM2B_26808549_Chip-Seq_DND41_Human1.25939200
114* KDM2B_26808549_Chip-Seq_K562_Human1.25753945
115* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25431785
116AR_19668381_ChIP-Seq_PC3_Human1.24763965
117* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24063863
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23965006
119* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23833556
120TP53_16413492_ChIP-PET_HCT116_Human1.23658505
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22967074
122ESR1_21235772_ChIP-Seq_MCF-7_Human1.22136141
123CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21908071
124POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21491852
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21429554
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21429554
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20281137
128RNF2_27304074_Chip-Seq_NSC_Mouse1.17804558
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.17597096
130CIITA_25753668_ChIP-Seq_RAJI_Human1.17569107
131TFEB_21752829_ChIP-Seq_HELA_Human1.17317150
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16645006
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15130989
134BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15071091
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14938089
136STAT3_23295773_ChIP-Seq_U87_Human1.14887350
137TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.14817979
138YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14792758
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13669630
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12772767
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12359329
142* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11315285
143AR_25329375_ChIP-Seq_VCAP_Human1.11298114
144NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10692930
145UBF1/2_26484160_Chip-Seq_HMECs_Human1.08860668
146RUNX1_27514584_Chip-Seq_MCF-7_Human1.08605258
147EP300_21415370_ChIP-Seq_HL-1_Mouse1.06817418
148IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06345935
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06070130
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05326859
151STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04963339
152* RUNX2_22187159_ChIP-Seq_PCA_Human1.04743193
153SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04584539
154SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04584539
155WT1_19549856_ChIP-ChIP_CCG9911_Human1.04287937
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04282273
157ZNF274_21170338_ChIP-Seq_K562_Hela1.03964221
158* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03483236
159CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03110494
160OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02993594
161TCF4_23295773_ChIP-Seq_U87_Human1.02668684
162SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02321112
163TP53_18474530_ChIP-ChIP_U2OS_Human1.01437301
164CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00707465
165TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00496628
166* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99823790
167TCF4_18268006_ChIP-ChIP_LS174T_Human0.97941793
168* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97628904
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96637582
170ISL1_27105846_Chip-Seq_CPCs_Mouse0.95727482
171SMAD4_21741376_ChIP-Seq_HESCs_Human0.95696526
172TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94561234
173MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94435322
174HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94331689
175ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94207525
176MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94111239
177ZNF263_19887448_ChIP-Seq_K562_Human0.94069778
178TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93990055
179SMAD3_21741376_ChIP-Seq_ESCs_Human0.93220448
180MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91844627
181EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90632705
182CREB1_26743006_Chip-Seq_LNCaP_Human0.87722570
183ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85984365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.22933838
2MP0004859_abnormal_synaptic_plasticity4.17014907
3MP0003880_abnormal_central_pattern3.08264638
4MP0000778_abnormal_nervous_system2.94496676
5MP0004270_analgesia2.84623979
6MP0002009_preneoplasia2.74132104
7MP0000569_abnormal_digit_pigmentation2.73679918
8MP0003635_abnormal_synaptic_transmissio2.73660763
9MP0005423_abnormal_somatic_nervous2.65506118
10MP0010234_abnormal_vibrissa_follicle2.47833277
11MP0010094_abnormal_chromosome_stability2.42838345
12MP0003705_abnormal_hypodermis_morpholog2.41235792
13MP0003111_abnormal_nucleus_morphology2.32108250
14MP0003787_abnormal_imprinting2.28064969
15MP0002063_abnormal_learning/memory/cond2.27824273
16MP0005076_abnormal_cell_differentiation2.22357728
17MP0003077_abnormal_cell_cycle2.20525449
18MP0001486_abnormal_startle_reflex2.12794672
19MP0002184_abnormal_innervation2.08855822
20MP0006292_abnormal_olfactory_placode2.00623189
21MP0010352_gastrointestinal_tract_polyps1.94320484
22MP0009745_abnormal_behavioral_response1.93757872
23MP0002064_seizures1.90910280
24MP0004885_abnormal_endolymph1.82566278
25MP0003890_abnormal_embryonic-extraembry1.77224158
26MP0002572_abnormal_emotion/affect_behav1.76517312
27MP0002734_abnormal_mechanical_nocicepti1.76497613
28MP0009046_muscle_twitch1.71553666
29MP0005394_taste/olfaction_phenotype1.69437243
30MP0005499_abnormal_olfactory_system1.69437243
31MP0008789_abnormal_olfactory_epithelium1.67186124
32MP0002697_abnormal_eye_size1.64517663
33MP0004811_abnormal_neuron_physiology1.64291760
34MP0001984_abnormal_olfaction1.64103180
35MP0000350_abnormal_cell_proliferation1.63875399
36MP0004808_abnormal_hematopoietic_stem1.63794410
37MP0004742_abnormal_vestibular_system1.61603506
38MP0003385_abnormal_body_wall1.61320394
39MP0002938_white_spotting1.61226676
40MP0002557_abnormal_social/conspecific_i1.59964806
41MP0002272_abnormal_nervous_system1.58849672
42MP0009250_abnormal_appendicular_skeleto1.57763753
43MP0008961_abnormal_basal_metabolism1.56027744
44MP0000955_abnormal_spinal_cord1.55592022
45MP0004264_abnormal_extraembryonic_tissu1.54718463
46MP0002877_abnormal_melanocyte_morpholog1.54661275
47MP0001968_abnormal_touch/_nociception1.53957594
48MP0008569_lethality_at_weaning1.53192251
49MP0008932_abnormal_embryonic_tissue1.49813353
50MP0004197_abnormal_fetal_growth/weight/1.49682193
51MP0003693_abnormal_embryo_hatching1.48814789
52MP0002882_abnormal_neuron_morphology1.48434947
53MP0004858_abnormal_nervous_system1.47710609
54MP0004957_abnormal_blastocyst_morpholog1.45573620
55MP0003122_maternal_imprinting1.45078277
56MP0000049_abnormal_middle_ear1.44528083
57MP0004185_abnormal_adipocyte_glucose1.44137189
58MP0003136_yellow_coat_color1.44002736
59MP0002067_abnormal_sensory_capabilities1.43921374
60MP0000566_synostosis1.43263681
61MP0000631_abnormal_neuroendocrine_gland1.42515334
62MP0002084_abnormal_developmental_patter1.41173456
63MP0009780_abnormal_chondrocyte_physiolo1.38928746
64MP0003943_abnormal_hepatobiliary_system1.38840156
65MP0003984_embryonic_growth_retardation1.38554836
66MP0001672_abnormal_embryogenesis/_devel1.38278588
67MP0005380_embryogenesis_phenotype1.38278588
68MP0001299_abnormal_eye_distance/1.36782559
69MP0003755_abnormal_palate_morphology1.36337980
70MP0003115_abnormal_respiratory_system1.36005426
71MP0001730_embryonic_growth_arrest1.35788739
72MP0005187_abnormal_penis_morphology1.35114131
73MP0002088_abnormal_embryonic_growth/wei1.33539770
74MP0003453_abnormal_keratinocyte_physiol1.32199054
75MP0002092_abnormal_eye_morphology1.30772992
76MP0002249_abnormal_larynx_morphology1.29455410
77MP0002751_abnormal_autonomic_nervous1.29445420
78MP0004134_abnormal_chest_morphology1.28034130
79MP0002152_abnormal_brain_morphology1.26937276
80MP0003938_abnormal_ear_development1.26454932
81MP0003091_abnormal_cell_migration1.26333211
82MP0002085_abnormal_embryonic_tissue1.26189386
83MP0001177_atelectasis1.25788432
84MP0010030_abnormal_orbit_morphology1.24910498
85MP0000377_abnormal_hair_follicle1.24717168
86MP0003935_abnormal_craniofacial_develop1.24037933
87MP0002233_abnormal_nose_morphology1.23692808
88MP0001346_abnormal_lacrimal_gland1.23377628
89MP0000428_abnormal_craniofacial_morphol1.23340525
90MP0001697_abnormal_embryo_size1.22977421
91MP0009672_abnormal_birth_weight1.22230016
92MP0005501_abnormal_skin_physiology1.21639279
93MP0002098_abnormal_vibrissa_morphology1.21079303
94MP0006276_abnormal_autonomic_nervous1.20669077
95MP0003861_abnormal_nervous_system1.20609399
96MP0005248_abnormal_Harderian_gland1.20570479
97MP0002086_abnormal_extraembryonic_tissu1.20389100
98MP0001849_ear_inflammation1.19845756
99MP0000920_abnormal_myelination1.19294208
100MP0003121_genomic_imprinting1.19146039
101MP0003123_paternal_imprinting1.18745390
102MP0002396_abnormal_hematopoietic_system1.18699658
103MP0004924_abnormal_behavior1.18144811
104MP0005386_behavior/neurological_phenoty1.18144811
105MP0002733_abnormal_thermal_nociception1.16799793
106MP0002080_prenatal_lethality1.15921205
107MP0001970_abnormal_pain_threshold1.15005403
108MP0003937_abnormal_limbs/digits/tail_de1.14332412
109MP0002796_impaired_skin_barrier1.14241413
110MP0003566_abnormal_cell_adhesion1.11067024
111MP0004381_abnormal_hair_follicle1.10525553
112MP0005171_absent_coat_pigmentation1.10407247
113MP0001348_abnormal_lacrimal_gland1.10172932
114MP0009703_decreased_birth_body1.09258889
115MP0005220_abnormal_exocrine_pancreas1.09198308
116MP0002735_abnormal_chemical_nociception1.08898876
117MP0005621_abnormal_cell_physiology1.08836683
118MP0005409_darkened_coat_color1.08196151
119MP0005551_abnormal_eye_electrophysiolog1.06409459
120MP0000383_abnormal_hair_follicle1.06151760
121MP0002066_abnormal_motor_capabilities/c1.05853821
122MP0002116_abnormal_craniofacial_bone1.05750384
123MP0000537_abnormal_urethra_morphology1.04475672
124MP0002752_abnormal_somatic_nervous1.00941757
125MP0010307_abnormal_tumor_latency1.00256817
126MP0001188_hyperpigmentation0.99405074
127MP0003634_abnormal_glial_cell0.98503287
128MP0001502_abnormal_circadian_rhythm0.98396337
129MP0005623_abnormal_meninges_morphology0.98158290
130MP0003941_abnormal_skin_development0.97769626
131MP0003221_abnormal_cardiomyocyte_apopto0.97383257
132MP0002736_abnormal_nociception_after0.95778053
133MP0002177_abnormal_outer_ear0.95015199
134MP0005257_abnormal_intraocular_pressure0.94705581
135MP0008007_abnormal_cellular_replicative0.94489918
136MP0001286_abnormal_eye_development0.93822952
137MP0002081_perinatal_lethality0.93146323
138MP0000432_abnormal_head_morphology0.92740478
139MP0009053_abnormal_anal_canal0.92646631
140MP0008058_abnormal_DNA_repair0.92226798
141MP0001915_intracranial_hemorrhage0.90843789
142MP0005645_abnormal_hypothalamus_physiol0.90681096
143MP0005253_abnormal_eye_physiology0.90473363
144MP0002234_abnormal_pharynx_morphology0.89965905
145MP0005646_abnormal_pituitary_gland0.89330081
146MP0000427_abnormal_hair_cycle0.89195262
147MP0002638_abnormal_pupillary_reflex0.88872149
148MP0005384_cellular_phenotype0.88680719
149MP0003137_abnormal_impulse_conducting0.86615221
150MP0001440_abnormal_grooming_behavior0.86600060
151MP0003942_abnormal_urinary_system0.85698353
152MP0006072_abnormal_retinal_apoptosis0.85123838
153MP0000762_abnormal_tongue_morphology0.84047227
154MP0002932_abnormal_joint_morphology0.82476509
155MP0003633_abnormal_nervous_system0.82360116
156MP0001485_abnormal_pinna_reflex0.81892399
157MP0001270_distended_abdomen0.79367532
158MP0000534_abnormal_ureter_morphology0.79012023
159MP0000579_abnormal_nail_morphology0.78882382
160MP0004142_abnormal_muscle_tone0.78186640
161MP0002822_catalepsy0.77955678
162MP0001943_abnormal_respiration0.77240156
163MP0001340_abnormal_eyelid_morphology0.75910398
164MP0003631_nervous_system_phenotype0.74845762
165MP0004233_abnormal_muscle_weight0.73390687
166MP0010678_abnormal_skin_adnexa0.73077665
167MP0003632_abnormal_nervous_system0.72966002

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)3.12169121
2Short 4th metacarpal (HP:0010044)2.99910400
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.99910400
4Myokymia (HP:0002411)2.95168161
5Hepatoblastoma (HP:0002884)2.94586616
6Focal motor seizures (HP:0011153)2.93362478
7Broad-based gait (HP:0002136)2.92723551
8Cortical dysplasia (HP:0002539)2.87435155
9Deep philtrum (HP:0002002)2.83197964
10Ankle clonus (HP:0011448)2.78367025
11Heterotopia (HP:0002282)2.74714748
12Alacrima (HP:0000522)2.70239805
13Shallow orbits (HP:0000586)2.67238642
14Action tremor (HP:0002345)2.62509210
15Focal seizures (HP:0007359)2.57471485
16Abnormality of the corticospinal tract (HP:0002492)2.55320941
17Overlapping toe (HP:0001845)2.54979018
18Elfin facies (HP:0004428)2.50601203
19Exotropia (HP:0000577)2.48954071
20Overriding aorta (HP:0002623)2.46992960
21Increased nuchal translucency (HP:0010880)2.46354632
22Urinary urgency (HP:0000012)2.44844117
23Hyperacusis (HP:0010780)2.44553020
24Hyperventilation (HP:0002883)2.41139057
25Truncal ataxia (HP:0002078)2.36819197
26Febrile seizures (HP:0002373)2.36061197
27Excessive salivation (HP:0003781)2.32411240
28Drooling (HP:0002307)2.32411240
29Sparse lateral eyebrow (HP:0005338)2.32383551
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30361448
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.30361448
32Decreased lacrimation (HP:0000633)2.29924298
33Megalencephaly (HP:0001355)2.29683724
34Broad ribs (HP:0000885)2.28113990
35Urinary bladder sphincter dysfunction (HP:0002839)2.27821152
36Macroorchidism (HP:0000053)2.27204805
37Germ cell neoplasia (HP:0100728)2.23998456
38Missing ribs (HP:0000921)2.23723256
39Abnormality of the 4th metacarpal (HP:0010012)2.23525798
40Epileptic encephalopathy (HP:0200134)2.23386649
41Termporal pattern (HP:0011008)2.20274283
42Insidious onset (HP:0003587)2.20274283
43Midline defect of the nose (HP:0004122)2.19199126
44Supranuclear gaze palsy (HP:0000605)2.18902897
45Volvulus (HP:0002580)2.17824440
46High anterior hairline (HP:0009890)2.17308427
47Spastic gait (HP:0002064)2.16863541
48Aqueductal stenosis (HP:0002410)2.16432791
49Abnormality of the distal phalanx of the thumb (HP:0009617)2.15230724
50Agitation (HP:0000713)2.13972524
51Poor eye contact (HP:0000817)2.13610097
52Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13473620
53Long palpebral fissure (HP:0000637)2.12023949
54Intellectual disability, moderate (HP:0002342)2.09574047
55Renal duplication (HP:0000075)2.07119651
56Impaired social interactions (HP:0000735)2.06592387
57Abnormal social behavior (HP:0012433)2.06592387
58Cutaneous finger syndactyly (HP:0010554)2.06143219
59Insomnia (HP:0100785)2.03964382
60Impaired vibration sensation in the lower limbs (HP:0002166)2.03962454
61Septate vagina (HP:0001153)2.03648388
62Renovascular hypertension (HP:0100817)2.03303260
63Dysmetric saccades (HP:0000641)2.01425388
64Genetic anticipation (HP:0003743)2.00624138
65Pheochromocytoma (HP:0002666)2.00077642
66Gaze-evoked nystagmus (HP:0000640)1.98918163
67Abnormality of the diencephalon (HP:0010662)1.98337665
68Stereotypic behavior (HP:0000733)1.97795646
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95899775
70Spinal cord lesions (HP:0100561)1.95524108
71Syringomyelia (HP:0003396)1.95524108
72Obsessive-compulsive behavior (HP:0000722)1.93113239
73Large earlobe (HP:0009748)1.92857571
74Medulloblastoma (HP:0002885)1.92638918
75Pseudobulbar signs (HP:0002200)1.92005971
76Blue irides (HP:0000635)1.90097627
77Curly hair (HP:0002212)1.89724020
78Urethral obstruction (HP:0000796)1.89663945
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.89576105
80Abnormality of the lower motor neuron (HP:0002366)1.88872651
81Visual hallucinations (HP:0002367)1.88366334
82Amblyopia (HP:0000646)1.88318056
83Broad face (HP:0000283)1.87839566
84Inappropriate behavior (HP:0000719)1.87836340
85Ankyloglossia (HP:0010296)1.87399401
86Tented upper lip vermilion (HP:0010804)1.86972415
87Abnormality of the fingertips (HP:0001211)1.86581536
88Flat cornea (HP:0007720)1.86246557
89Deviation of the thumb (HP:0009603)1.86198340
90Patellar dislocation (HP:0002999)1.83772057
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83711754
92Proximal placement of thumb (HP:0009623)1.82605194
93Deep palmar crease (HP:0006191)1.81774836
94Mutism (HP:0002300)1.81323560
95Cutaneous syndactyly (HP:0012725)1.81056466
96Lip pit (HP:0100267)1.80382116
97Pointed chin (HP:0000307)1.79665988
98Widely spaced teeth (HP:0000687)1.79356444
99Anteriorly placed anus (HP:0001545)1.79217945
100Cubitus valgus (HP:0002967)1.78971636
101Scanning speech (HP:0002168)1.78884193
102Sandal gap (HP:0001852)1.78511010
103Absent speech (HP:0001344)1.77978538
104Glossoptosis (HP:0000162)1.77715697
105Sacral dimple (HP:0000960)1.77690666
106Ulnar bowing (HP:0003031)1.77673827
107Hypoplastic nipples (HP:0002557)1.76628196
108Chromsome breakage (HP:0040012)1.76542831
109Long eyelashes (HP:0000527)1.76426789
110Trigonocephaly (HP:0000243)1.75992912
111Low anterior hairline (HP:0000294)1.75864083
112Facial hemangioma (HP:0000329)1.74860060
113Poikiloderma (HP:0001029)1.74615952
114Open mouth (HP:0000194)1.74456928
115Anal stenosis (HP:0002025)1.74319545
116Sporadic (HP:0003745)1.73847142
117Asymmetry of the thorax (HP:0001555)1.73593189
118Overgrowth (HP:0001548)1.72174097
119Relative macrocephaly (HP:0004482)1.71631320
120Protruding tongue (HP:0010808)1.71242742
121Limb dystonia (HP:0002451)1.70431392
122Vertebral arch anomaly (HP:0008438)1.69369673
123Coronal craniosynostosis (HP:0004440)1.69034120
124Buphthalmos (HP:0000557)1.68188573
125Depression (HP:0000716)1.67658419
126Abnormality of the gastric mucosa (HP:0004295)1.67563289
127Intention tremor (HP:0002080)1.67457393
128Capillary hemangiomas (HP:0005306)1.66857732
129Hypopigmentation of the fundus (HP:0007894)1.66821250
130Lower limb muscle weakness (HP:0007340)1.65814538
131Dysmetria (HP:0001310)1.65293223
132Neoplasm of the oral cavity (HP:0100649)1.64579698
133Postural tremor (HP:0002174)1.63919209
134Arnold-Chiari malformation (HP:0002308)1.62887627
135Thick eyebrow (HP:0000574)1.62034351
136Broad metatarsal (HP:0001783)1.60984563
137Papillary thyroid carcinoma (HP:0002895)1.60907927
138Oligodactyly (HP:0012165)1.60888866
139Subacute progressive viral hepatitis (HP:0006572)1.60710226
140Nephroblastoma (Wilms tumor) (HP:0002667)1.60639394
141Myelomeningocele (HP:0002475)1.60464204
142Morphological abnormality of the middle ear (HP:0008609)1.60308376
143Autism (HP:0000717)1.60122852
144Cutis marmorata (HP:0000965)1.59099512
145Hammertoe (HP:0001765)1.59074198
146Spina bifida occulta (HP:0003298)1.58905079
147Leiomyosarcoma (HP:0100243)1.58697404
148Uterine leiomyosarcoma (HP:0002891)1.58697404
149Abnormality of the intervertebral disk (HP:0005108)1.58552617
150Cystic hygroma (HP:0000476)1.58517665
151Thickened helices (HP:0000391)1.57961297
152Neoplasm of the peripheral nervous system (HP:0100007)1.57555750
153Bowel incontinence (HP:0002607)1.57070382
154Dental malocclusion (HP:0000689)1.56267373
155Cafe-au-lait spot (HP:0000957)1.56047287
156Smooth philtrum (HP:0000319)1.55799472
157Obstructive sleep apnea (HP:0002870)1.55796427
158Transitional cell carcinoma of the bladder (HP:0006740)1.55562564
159Selective tooth agenesis (HP:0001592)1.54260988
160Hamartoma (HP:0010566)1.50909448
161Abnormal large intestine physiology (HP:0012700)1.50407204
162Progressive external ophthalmoplegia (HP:0000590)1.49395854
163Freckling (HP:0001480)1.49311084
164Neonatal hypoglycemia (HP:0001998)1.49215772
165Embryonal renal neoplasm (HP:0011794)1.48880043
166Broad nasal tip (HP:0000455)1.48478106
167Abnormality of chromosome segregation (HP:0002916)1.47381777
168Natal tooth (HP:0000695)1.47194466
169Abnormality of the antihelix (HP:0009738)1.44393644
170Spastic paraplegia (HP:0001258)1.43668035
171Attention deficit hyperactivity disorder (HP:0007018)1.42978125
172Partial agenesis of the corpus callosum (HP:0001338)1.42569238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.21510500
2CDK123.49594708
3MAP3K103.33534873
4EEF2K3.00066808
5TRIB32.93499868
6MAP3K42.49907000
7EPHA42.47312115
8NTRK32.24588450
9NTRK22.21712467
10PAK62.13374078
11DYRK22.03693161
12MAP2K72.02019577
13SRPK12.00120615
14MAPK131.88056401
15MAP3K91.88016821
16KSR11.85926892
17CDC71.82068270
18MINK11.76762278
19UHMK11.75523553
20CASK1.61132489
21EPHB21.59379986
22SIK21.56839525
23SMG11.56260325
24CDK61.56218718
25SCYL21.55496612
26PRKD31.54312449
27MAP3K21.53187572
28DAPK21.52956801
29SGK4941.52003026
30SGK2231.52003026
31FGFR21.48818359
32EPHA31.48016986
33INSRR1.47873214
34ERBB31.47479318
35PHKG11.41062869
36PHKG21.41062869
37PKN21.40755359
38DYRK1B1.37731534
39TNIK1.34902411
40MTOR1.34000121
41TYRO31.32813732
42CAMK1G1.32403248
43CSNK1A1L1.32181579
44PKN11.31857114
45WEE11.31737580
46LATS11.27770218
47MKNK11.27375700
48CDK51.23549803
49SIK11.22987659
50MAP3K61.22735941
51RPS6KA41.22345981
52CSNK1G21.20657847
53TSSK61.20337267
54KSR21.18950308
55CAMKK11.18634290
56RAF11.17042736
57PRKCH1.16343630
58RPS6KB21.14830569
59STK38L1.13697182
60SGK31.13099814
61DYRK1A1.12625803
62SGK21.09027980
63STK111.07282043
64CDK191.05271981
65BCR1.04521063
66CDK71.04184088
67NTRK11.04089428
68STK391.03974035
69MKNK21.03351107
70WNK11.02835098
71CSNK1G31.00603533
72NEK61.00556387
73IRAK30.96020432
74PRPF4B0.95027927
75IRAK20.90479225
76PLK20.90401087
77HIPK20.89890213
78EIF2AK10.89798568
79NUAK10.88484721
80LATS20.88438239
81ERBB20.87495348
82MARK20.87013078
83PBK0.84974466
84RPS6KA20.84787925
85STK30.83950652
86OXSR10.83645630
87CDK40.83597906
88BMPR1B0.82841078
89RIPK10.82350583
90ATR0.81049357
91AKT30.79483727
92RET0.77720424
93CHEK20.74515651
94CHEK10.73367414
95CSNK1G10.72742992
96CAMKK20.71000656
97MAP2K40.70872811
98MST1R0.67418659
99STK380.67325600
100FGFR40.66949820
101LIMK10.66312049
102DMPK0.66237355
103MAPK100.66171405
104CAMK1D0.65648805
105MAPK80.65060023
106ATM0.64763667
107CAMK40.64298070
108LMTK20.63546250
109CAMK2B0.63223647
110SGK10.63191872
111CDK20.63169279
112PAK30.63164281
113ICK0.62400483
114PRKCE0.62090900
115DYRK30.62066397
116ALK0.61747362
117STK240.61098658
118TRIM280.60095717
119BRD40.59958923
120PRKCG0.59740716
121ERBB40.59466818
122CDK30.59008097
123ROCK10.58382580
124ROCK20.57684338
125CDK10.57507615
126PRKCZ0.56724742
127PRKD20.56386085
128TTK0.56334733
129CDK180.56130848
130MAPK90.53987032
131PAK40.53846296
132CDK150.52753535
133CAMK10.52622625
134CDC42BPA0.52328342
135PDGFRA0.51737513
136PDGFRB0.51224062
137DDR20.50517490
138AURKB0.50401930
139MET0.49587535
140CDK140.49060802
141FES0.48987556
142PRKDC0.48843549
143FYN0.48774330
144PTK20.48526571
145PNCK0.47988933
146CAMK2A0.47291849
147PINK10.46912844
148EIF2AK20.46906534
149RPS6KA30.46273617
150CDK11A0.45309514
151SIK30.44653896
152GSK3B0.44574430
153YES10.44168682
154FGR0.41472715
155EPHB10.41468117

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.18280621
2Nicotine addiction_Homo sapiens_hsa050332.15130569
3Glutamatergic synapse_Homo sapiens_hsa047242.13858691
4Olfactory transduction_Homo sapiens_hsa047402.07744749
5Circadian entrainment_Homo sapiens_hsa047132.04953333
6GABAergic synapse_Homo sapiens_hsa047271.92185642
7Non-homologous end-joining_Homo sapiens_hsa034501.90234424
8Morphine addiction_Homo sapiens_hsa050321.88635713
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82662720
10Dopaminergic synapse_Homo sapiens_hsa047281.77227034
11Thyroid cancer_Homo sapiens_hsa052161.76572596
12Cholinergic synapse_Homo sapiens_hsa047251.71885869
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69481151
14Long-term potentiation_Homo sapiens_hsa047201.68811236
15Synaptic vesicle cycle_Homo sapiens_hsa047211.65371340
16Cell cycle_Homo sapiens_hsa041101.64977222
17mRNA surveillance pathway_Homo sapiens_hsa030151.61281540
18Amphetamine addiction_Homo sapiens_hsa050311.49334587
19Adherens junction_Homo sapiens_hsa045201.48356796
20Long-term depression_Homo sapiens_hsa047301.45838985
21Bladder cancer_Homo sapiens_hsa052191.43662846
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.43621530
23Serotonergic synapse_Homo sapiens_hsa047261.41739583
24Phototransduction_Homo sapiens_hsa047441.41689486
25Gap junction_Homo sapiens_hsa045401.41356651
26Taste transduction_Homo sapiens_hsa047421.41246433
27ErbB signaling pathway_Homo sapiens_hsa040121.40316778
28Renin secretion_Homo sapiens_hsa049241.39888831
29Inositol phosphate metabolism_Homo sapiens_hsa005621.39667466
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39502023
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39315254
32Cocaine addiction_Homo sapiens_hsa050301.38231682
33Gastric acid secretion_Homo sapiens_hsa049711.35291862
34Prostate cancer_Homo sapiens_hsa052151.34055807
35Insulin secretion_Homo sapiens_hsa049111.32729033
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32638158
37Lysine degradation_Homo sapiens_hsa003101.32259599
38Oxytocin signaling pathway_Homo sapiens_hsa049211.30458817
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30131856
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29639967
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29469654
42GnRH signaling pathway_Homo sapiens_hsa049121.28225067
43Salivary secretion_Homo sapiens_hsa049701.27106283
44Glioma_Homo sapiens_hsa052141.26602338
45Type II diabetes mellitus_Homo sapiens_hsa049301.26463290
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23225504
47Renal cell carcinoma_Homo sapiens_hsa052111.22287815
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22210801
49Endometrial cancer_Homo sapiens_hsa052131.21266628
50cAMP signaling pathway_Homo sapiens_hsa040241.17305264
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16747887
52Melanogenesis_Homo sapiens_hsa049161.16401616
53Small cell lung cancer_Homo sapiens_hsa052221.13708301
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13088700
55Spliceosome_Homo sapiens_hsa030401.11203010
56Wnt signaling pathway_Homo sapiens_hsa043101.11175974
57RNA transport_Homo sapiens_hsa030131.10908433
58Colorectal cancer_Homo sapiens_hsa052101.09102381
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07868046
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.07238207
61Hedgehog signaling pathway_Homo sapiens_hsa043401.05858375
62Basal cell carcinoma_Homo sapiens_hsa052171.05456416
63Acute myeloid leukemia_Homo sapiens_hsa052211.02671086
64Calcium signaling pathway_Homo sapiens_hsa040201.02118254
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01544328
66DNA replication_Homo sapiens_hsa030301.01179515
67Estrogen signaling pathway_Homo sapiens_hsa049151.00563335
68Dorso-ventral axis formation_Homo sapiens_hsa043200.97975755
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95442382
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94661317
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.94526357
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93864470
73Dilated cardiomyopathy_Homo sapiens_hsa054140.93476144
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92925821
75MAPK signaling pathway_Homo sapiens_hsa040100.92474044
76Hippo signaling pathway_Homo sapiens_hsa043900.92159240
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88505549
78VEGF signaling pathway_Homo sapiens_hsa043700.88179669
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88002681
80AMPK signaling pathway_Homo sapiens_hsa041520.87884950
81Hepatitis B_Homo sapiens_hsa051610.87239789
82Ras signaling pathway_Homo sapiens_hsa040140.84157204
83Alcoholism_Homo sapiens_hsa050340.83540700
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83442424
85Choline metabolism in cancer_Homo sapiens_hsa052310.82501390
86Rap1 signaling pathway_Homo sapiens_hsa040150.81403217
87Chronic myeloid leukemia_Homo sapiens_hsa052200.80429487
88Viral carcinogenesis_Homo sapiens_hsa052030.80157987
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79180638
90FoxO signaling pathway_Homo sapiens_hsa040680.78113146
91Vibrio cholerae infection_Homo sapiens_hsa051100.77980632
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77207714
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76333443
94B cell receptor signaling pathway_Homo sapiens_hsa046620.75405735
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75371176
96Shigellosis_Homo sapiens_hsa051310.75216807
97Pathways in cancer_Homo sapiens_hsa052000.75113867
98mTOR signaling pathway_Homo sapiens_hsa041500.74302297
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.73926179
100Proteoglycans in cancer_Homo sapiens_hsa052050.71832202
101Tight junction_Homo sapiens_hsa045300.71699233
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.71023561
103Viral myocarditis_Homo sapiens_hsa054160.70879891
104Sphingolipid metabolism_Homo sapiens_hsa006000.70302452
105Non-small cell lung cancer_Homo sapiens_hsa052230.69887106
106T cell receptor signaling pathway_Homo sapiens_hsa046600.69725519
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68461187
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68444478
109Vitamin B6 metabolism_Homo sapiens_hsa007500.68438500
110Pancreatic cancer_Homo sapiens_hsa052120.67987021
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67715964
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65098625
113Prolactin signaling pathway_Homo sapiens_hsa049170.65095740
114TGF-beta signaling pathway_Homo sapiens_hsa043500.64562113
115Ovarian steroidogenesis_Homo sapiens_hsa049130.64552482
116Endocytosis_Homo sapiens_hsa041440.63965255
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63380509
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63243054
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63219735
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62919926
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62420229
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62183974
123Focal adhesion_Homo sapiens_hsa045100.61631108
124Notch signaling pathway_Homo sapiens_hsa043300.61167841
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60965762
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60252115
127Chemokine signaling pathway_Homo sapiens_hsa040620.59531896
128Pancreatic secretion_Homo sapiens_hsa049720.59426315
129Oocyte meiosis_Homo sapiens_hsa041140.58637656
130Insulin signaling pathway_Homo sapiens_hsa049100.57725658
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56192397
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55738201
133MicroRNAs in cancer_Homo sapiens_hsa052060.55343689
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54848146
135Thyroid hormone synthesis_Homo sapiens_hsa049180.54470301
136Circadian rhythm_Homo sapiens_hsa047100.54223580
137Melanoma_Homo sapiens_hsa052180.53841546
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53808652
139Hepatitis C_Homo sapiens_hsa051600.52131031

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