POGZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.38299973
2histone H3-K4 trimethylation (GO:0080182)4.17449922
3presynaptic membrane assembly (GO:0097105)3.74628649
4histone H3-K4 methylation (GO:0051568)3.67365787
5nuclear pore complex assembly (GO:0051292)3.66595270
6* mitotic sister chromatid cohesion (GO:0007064)3.58955141
7DNA strand renaturation (GO:0000733)3.49262340
8cytoplasmic mRNA processing body assembly (GO:0033962)3.43663891
9negative regulation of histone methylation (GO:0031061)3.42855892
10presynaptic membrane organization (GO:0097090)3.39371555
11nuclear pore organization (GO:0006999)3.38025926
12embryonic retina morphogenesis in camera-type eye (GO:0060059)3.29509916
13mRNA splice site selection (GO:0006376)3.29434896
14regulation of RNA export from nucleus (GO:0046831)3.27292217
15positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.15724701
16negative regulation of translation, ncRNA-mediated (GO:0040033)3.15601511
17regulation of translation, ncRNA-mediated (GO:0045974)3.15601511
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.15601511
19histone H4-K8 acetylation (GO:0043982)3.13439475
20histone H4-K5 acetylation (GO:0043981)3.13439475
21peptidyl-lysine trimethylation (GO:0018023)3.12328685
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.12094762
23histone H4-K16 acetylation (GO:0043984)3.10927323
24histone lysine methylation (GO:0034968)3.07281665
25stress granule assembly (GO:0034063)3.04453119
26paraxial mesoderm development (GO:0048339)3.01111608
27head development (GO:0060322)2.90034193
28histone H3-K9 methylation (GO:0051567)2.88142017
29histone H4-K12 acetylation (GO:0043983)2.87833476
30glucocorticoid receptor signaling pathway (GO:0042921)2.87500704
31regulation of DNA endoreduplication (GO:0032875)2.86847980
32regulation of NFAT protein import into nucleus (GO:0051532)2.83388591
33histone methylation (GO:0016571)2.81530998
34monoubiquitinated protein deubiquitination (GO:0035520)2.79392847
35layer formation in cerebral cortex (GO:0021819)2.76220472
36negative regulation of mRNA processing (GO:0050686)2.75794218
37regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.75153734
38NLS-bearing protein import into nucleus (GO:0006607)2.73565719
39negative regulation of dendrite development (GO:2000171)2.69379029
40central nervous system projection neuron axonogenesis (GO:0021952)2.68060004
41lateral sprouting from an epithelium (GO:0060601)2.68021530
42pore complex assembly (GO:0046931)2.63053682
43planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62919762
44positive regulation of RNA splicing (GO:0033120)2.61469605
45regulation of nucleobase-containing compound transport (GO:0032239)2.61296652
46regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60733316
47central nervous system neuron axonogenesis (GO:0021955)2.60400146
48pyrimidine nucleobase catabolic process (GO:0006208)2.59984773
49negative regulation of RNA splicing (GO:0033119)2.59619613
50negative regulation of dendrite morphogenesis (GO:0050774)2.59068460
51embryonic camera-type eye morphogenesis (GO:0048596)2.58914419
52hindbrain development (GO:0030902)2.58637474
53histone H4 acetylation (GO:0043967)2.57149392
54interkinetic nuclear migration (GO:0022027)2.56320078
55positive regulation of gene expression, epigenetic (GO:0045815)2.55329315
56regulation of histone H3-K27 methylation (GO:0061085)2.54582435
57regulation of histone H3-K9 methylation (GO:0051570)2.54521228
58postsynaptic membrane organization (GO:0001941)2.54260460
59negative regulation of mRNA metabolic process (GO:1903312)2.53665913
60regulation of histone H3-K4 methylation (GO:0051569)2.53404305
61cell migration in hindbrain (GO:0021535)2.53124506
62spinal cord development (GO:0021510)2.53038372
63establishment of nucleus localization (GO:0040023)2.52003672
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51919545
65apical protein localization (GO:0045176)2.51910348
66positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.50161324
67regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.50161324
68cerebellar Purkinje cell differentiation (GO:0021702)2.49259006
69histone H3-K9 modification (GO:0061647)2.48775295
70protein-DNA complex disassembly (GO:0032986)2.46980787
71nucleosome disassembly (GO:0006337)2.46980787
72cellular response to sterol (GO:0036315)2.45681375
73dendritic spine morphogenesis (GO:0060997)2.45038529
74heterochromatin organization (GO:0070828)2.44931624
75peptidyl-lysine methylation (GO:0018022)2.42784630
76regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.40645167
77axonal fasciculation (GO:0007413)2.39764454
78hippo signaling (GO:0035329)2.39268054
79vocalization behavior (GO:0071625)2.39115673
80DNA methylation (GO:0006306)2.37643864
81DNA alkylation (GO:0006305)2.37643864
82limb development (GO:0060173)2.37284867
83appendage development (GO:0048736)2.37284867
84neuron recognition (GO:0008038)2.37086720
85cerebral cortex development (GO:0021987)2.35830464
86nucleus localization (GO:0051647)2.35010218
87histone acetylation (GO:0016573)2.34555121
88histone deubiquitination (GO:0016578)2.33885923
89negative regulation of cytosolic calcium ion concentration (GO:0051481)2.32927530
90limb bud formation (GO:0060174)2.32595797
91cerebral cortex radially oriented cell migration (GO:0021799)2.32079060
92cellular response to cholesterol (GO:0071397)2.31921792
93synaptic vesicle docking involved in exocytosis (GO:0016081)2.31878617
94regulation of histone methylation (GO:0031060)2.31398162
95negative regulation of histone modification (GO:0031057)2.31229313
96regulation of Rac protein signal transduction (GO:0035020)2.31131688
97gene silencing by RNA (GO:0031047)2.30669494
98peptidyl-lysine dimethylation (GO:0018027)2.30493648
99internal peptidyl-lysine acetylation (GO:0018393)2.29572767
100gastrulation with mouth forming second (GO:0001702)2.28453185
101olfactory bulb development (GO:0021772)2.27675475
102regulation of neuron migration (GO:2001222)2.27486945
103glial cell proliferation (GO:0014009)2.27405888
104histone lysine demethylation (GO:0070076)2.26794039
105regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.26293312
106positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.26293312
107gene silencing (GO:0016458)2.24811540
108generation of neurons (GO:0048699)2.24745548
109neuron cell-cell adhesion (GO:0007158)2.24566984
110negative regulation of DNA repair (GO:0045738)2.24451585
111negative regulation of chromatin modification (GO:1903309)2.24289846
112histone H2A acetylation (GO:0043968)2.23633161
113positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.22678537
114peptidyl-arginine methylation (GO:0018216)2.22676639
115peptidyl-arginine N-methylation (GO:0035246)2.22676639
116peptidyl-lysine acetylation (GO:0018394)2.22232644
117dendrite morphogenesis (GO:0048813)2.21638172
118regulation of meiosis I (GO:0060631)2.21583676
119corticosteroid receptor signaling pathway (GO:0031958)2.21453570
120histone H3-K9 demethylation (GO:0033169)2.20974889
121regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.20682512
122heart morphogenesis (GO:0003007)2.20583386
123regulation of axon extension involved in axon guidance (GO:0048841)2.19945150
124synaptic vesicle endocytosis (GO:0048488)2.19907754
125response to pheromone (GO:0019236)2.19870478
126regulation of short-term neuronal synaptic plasticity (GO:0048172)2.19361437
127ionotropic glutamate receptor signaling pathway (GO:0035235)2.19291638
128embryonic foregut morphogenesis (GO:0048617)2.19278330
129regulation of axon guidance (GO:1902667)2.19097233
130positive regulation of mRNA processing (GO:0050685)2.18902341
131positive regulation of dendritic spine morphogenesis (GO:0061003)2.18866716
132regulation of telomere maintenance (GO:0032204)2.18739293
133DNA methylation or demethylation (GO:0044728)2.18735291
134regulation of mRNA splicing, via spliceosome (GO:0048024)2.18442530
135histone H3-K36 demethylation (GO:0070544)2.17732365
136sympathetic nervous system development (GO:0048485)2.17731143
137neurotransmitter-gated ion channel clustering (GO:0072578)2.15584732
138negative regulation of neurotransmitter secretion (GO:0046929)2.15362186
139regulation of respiratory system process (GO:0044065)2.14294765
140microtubule anchoring (GO:0034453)2.12928620
141phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.12377008
142fibroblast migration (GO:0010761)2.11860848
143myotube differentiation (GO:0014902)2.11699052
144positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.10618638
145dorsal/ventral axis specification (GO:0009950)2.10049363
146positive regulation of CREB transcription factor activity (GO:0032793)2.09325680
147prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.08482364
148atrial cardiac muscle cell action potential (GO:0086014)2.08146361
149genitalia morphogenesis (GO:0035112)2.07642175
150regulation of dendritic spine morphogenesis (GO:0061001)2.06170756
151chromatin silencing (GO:0006342)2.03601404
152sister chromatid segregation (GO:0000819)2.03326125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.62749567
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.55452659
3E2F7_22180533_ChIP-Seq_HELA_Human3.44313370
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.35603321
5EZH2_22144423_ChIP-Seq_EOC_Human3.22029855
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88854811
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.80339360
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.68709110
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.54407596
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38163003
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.24681427
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.97895877
13TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.97704729
14SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.94386975
15* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.91623199
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90116825
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89387882
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88766933
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87176186
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86684484
21ZFP281_27345836_Chip-Seq_ESCs_Mouse1.86574743
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83018803
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.82800040
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80976212
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80562984
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80354727
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.80017909
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79801409
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79764908
30* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79586456
31GBX2_23144817_ChIP-Seq_PC3_Human1.76968018
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.70647001
33FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.69096619
34TAF15_26573619_Chip-Seq_HEK293_Human1.63629842
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62205273
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62170403
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.60138589
38* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58916598
39DROSHA_22980978_ChIP-Seq_HELA_Human1.53978588
40* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52632935
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.51866177
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50965438
43ZNF274_21170338_ChIP-Seq_K562_Hela1.49984280
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.47191231
45MYC_22102868_ChIP-Seq_BL_Human1.46840989
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46752633
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46405944
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46405944
49P300_19829295_ChIP-Seq_ESCs_Human1.45915596
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45245463
51STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.45229831
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.44851043
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.42821150
54FUS_26573619_Chip-Seq_HEK293_Human1.42719629
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42698576
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41709523
57* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40821462
58TBX3_20139965_ChIP-Seq_ESCs_Mouse1.40306693
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40188495
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39307056
61TBX3_20139965_ChIP-Seq_MESCs_Mouse1.38757599
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.33347798
63ER_23166858_ChIP-Seq_MCF-7_Human1.33061156
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30916224
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30745998
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30404005
67IGF1R_20145208_ChIP-Seq_DFB_Human1.28578247
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26378851
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25846758
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25846758
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25304359
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24731083
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.24689261
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.23596627
75AR_25329375_ChIP-Seq_VCAP_Human1.22326480
76RNF2_27304074_Chip-Seq_NSC_Mouse1.22256950
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22202573
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22058471
79AR_19668381_ChIP-Seq_PC3_Human1.21907934
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20932285
81KDM2B_26808549_Chip-Seq_K562_Human1.20551869
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.19356278
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18358171
84BCAT_22108803_ChIP-Seq_LS180_Human1.18257216
85POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17556896
86REST_21632747_ChIP-Seq_MESCs_Mouse1.17291717
87STAT3_23295773_ChIP-Seq_U87_Human1.15373202
88EWS_26573619_Chip-Seq_HEK293_Human1.15359547
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15317303
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15311183
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14531506
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14469053
93RUNX2_22187159_ChIP-Seq_PCA_Human1.13905854
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13748692
95AR_21572438_ChIP-Seq_LNCaP_Human1.13084011
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12982967
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.12192881
98CIITA_25753668_ChIP-Seq_RAJI_Human1.11174959
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11165673
100SMAD4_21799915_ChIP-Seq_A2780_Human1.09487253
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.08856970
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08575919
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08339066
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08091316
105AHR_22903824_ChIP-Seq_MCF-7_Human1.07370458
106TCF7_22412390_ChIP-Seq_EML_Mouse1.07003230
107JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06750936
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06694244
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.06166031
110* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05835982
111* KDM2B_26808549_Chip-Seq_DND41_Human1.05823974
112KDM2B_26808549_Chip-Seq_REH_Human1.05570498
113* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04182401
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04110223
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03916348
116TP53_16413492_ChIP-PET_HCT116_Human1.03908313
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02828640
118NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02334993
119SOX9_26525672_Chip-Seq_HEART_Mouse1.01859386
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01758364
121TCF4_23295773_ChIP-Seq_U87_Human1.00893832
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00222496
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99940764
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99702477
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.99203591
126VDR_22108803_ChIP-Seq_LS180_Human0.99173618
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99078940
128EED_16625203_ChIP-ChIP_MESCs_Mouse0.98744706
129TCF4_22108803_ChIP-Seq_LS180_Human0.98579060
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98336637
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.98332667
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.98222111
133CBP_20019798_ChIP-Seq_JUKART_Human0.98122451
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98122451
135POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97852033
136CBX2_27304074_Chip-Seq_ESCs_Mouse0.97019989
137TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96857660
138SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96239366
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.95812483
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94574101
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94206656
142* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93366070
143RING1B_27294783_Chip-Seq_ESCs_Mouse0.92937230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.52617026
2MP0003890_abnormal_embryonic-extraembry2.89464526
3MP0003121_genomic_imprinting2.66792377
4MP0003122_maternal_imprinting2.62884472
5MP0003787_abnormal_imprinting2.36404040
6MP0006292_abnormal_olfactory_placode2.34517726
7MP0005423_abnormal_somatic_nervous2.22306272
8MP0004859_abnormal_synaptic_plasticity2.04802605
9MP0005076_abnormal_cell_differentiation2.03329516
10MP0008877_abnormal_DNA_methylation1.94800590
11MP0003123_paternal_imprinting1.94109488
12MP0010030_abnormal_orbit_morphology1.90090286
13MP0003880_abnormal_central_pattern1.82031734
14MP0000778_abnormal_nervous_system1.80111589
15MP0008961_abnormal_basal_metabolism1.77427153
16MP0005499_abnormal_olfactory_system1.74970653
17MP0005394_taste/olfaction_phenotype1.74970653
18MP0008057_abnormal_DNA_replication1.71496827
19MP0003283_abnormal_digestive_organ1.68579598
20MP0000383_abnormal_hair_follicle1.55787620
21MP0003935_abnormal_craniofacial_develop1.55051732
22MP0003385_abnormal_body_wall1.53478853
23MP0005248_abnormal_Harderian_gland1.52062537
24MP0009780_abnormal_chondrocyte_physiolo1.50839968
25MP0001293_anophthalmia1.49644045
26MP0000566_synostosis1.49477372
27MP0003861_abnormal_nervous_system1.45567943
28MP0002084_abnormal_developmental_patter1.43346690
29MP0003111_abnormal_nucleus_morphology1.42984710
30MP0005409_darkened_coat_color1.42944179
31MP0002653_abnormal_ependyma_morphology1.42246282
32MP0002009_preneoplasia1.41765637
33MP0003937_abnormal_limbs/digits/tail_de1.40281130
34MP0003755_abnormal_palate_morphology1.39953276
35MP0002938_white_spotting1.38799127
36MP0000428_abnormal_craniofacial_morphol1.38272828
37MP0002116_abnormal_craniofacial_bone1.36629794
38MP0009046_muscle_twitch1.36145948
39MP0001177_atelectasis1.33823483
40MP0009703_decreased_birth_body1.33584092
41MP0003119_abnormal_digestive_system1.33359010
42MP0003635_abnormal_synaptic_transmissio1.31587534
43MP0002085_abnormal_embryonic_tissue1.30978727
44MP0002734_abnormal_mechanical_nocicepti1.29741769
45MP0010094_abnormal_chromosome_stability1.28463907
46MP0004197_abnormal_fetal_growth/weight/1.27393319
47MP0000049_abnormal_middle_ear1.24551974
48MP0003942_abnormal_urinary_system1.24484490
49MP0009053_abnormal_anal_canal1.23453201
50MP0002063_abnormal_learning/memory/cond1.23331293
51MP0010678_abnormal_skin_adnexa1.23278381
52MP0005645_abnormal_hypothalamus_physiol1.22934618
53MP0004133_heterotaxia1.22311400
54MP0008789_abnormal_olfactory_epithelium1.21463256
55MP0003136_yellow_coat_color1.21167441
56MP0000537_abnormal_urethra_morphology1.20682798
57MP0000432_abnormal_head_morphology1.20259142
58MP0000534_abnormal_ureter_morphology1.19094157
59MP0001188_hyperpigmentation1.18645820
60MP0003943_abnormal_hepatobiliary_system1.17776618
61MP0005187_abnormal_penis_morphology1.17754763
62MP0002064_seizures1.17408797
63MP0000631_abnormal_neuroendocrine_gland1.17052978
64MP0003115_abnormal_respiratory_system1.16836309
65MP0009745_abnormal_behavioral_response1.16178268
66MP0008995_early_reproductive_senescence1.15887716
67MP0002735_abnormal_chemical_nociception1.14889268
68MP0001346_abnormal_lacrimal_gland1.14760294
69MP0005380_embryogenesis_phenotype1.14364592
70MP0001672_abnormal_embryogenesis/_devel1.14364592
71MP0000733_abnormal_muscle_development1.13769597
72MP0001299_abnormal_eye_distance/1.12490246
73MP0002233_abnormal_nose_morphology1.11156702
74MP0002249_abnormal_larynx_morphology1.10604370
75MP0003077_abnormal_cell_cycle1.09428106
76MP0004043_abnormal_pH_regulation1.09091197
77MP0003941_abnormal_skin_development1.08915184
78MP0002932_abnormal_joint_morphology1.08405678
79MP0002088_abnormal_embryonic_growth/wei1.07954255
80MP0004270_analgesia1.07574393
81MP0004924_abnormal_behavior1.07113651
82MP0005386_behavior/neurological_phenoty1.07113651
83MP0003984_embryonic_growth_retardation1.04890438
84MP0002152_abnormal_brain_morphology1.04832828
85MP0002081_perinatal_lethality1.04551677
86MP0001486_abnormal_startle_reflex1.03647257
87MP0005220_abnormal_exocrine_pancreas1.03355440
88MP0002697_abnormal_eye_size1.02629606
89MP0006072_abnormal_retinal_apoptosis1.02380329
90MP0005551_abnormal_eye_electrophysiolog1.02256025
91MP0005367_renal/urinary_system_phenotyp1.02210096
92MP0000516_abnormal_urinary_system1.02210096
93MP0001501_abnormal_sleep_pattern1.01413295
94MP0002638_abnormal_pupillary_reflex1.01403150
95MP0000350_abnormal_cell_proliferation1.00886035
96MP0004885_abnormal_endolymph1.00673141
97MP0009672_abnormal_birth_weight1.00462046
98MP0001502_abnormal_circadian_rhythm1.00004700
99MP0003567_abnormal_fetal_cardiomyocyte0.99246155
100MP0002114_abnormal_axial_skeleton0.99063864
101MP0001286_abnormal_eye_development0.99043468
102MP0003938_abnormal_ear_development0.98964947
103MP0002184_abnormal_innervation0.98500220
104MP0000427_abnormal_hair_cycle0.98059475
105MP0002272_abnormal_nervous_system0.97755061
106MP0001968_abnormal_touch/_nociception0.97659321
107MP0004233_abnormal_muscle_weight0.97407170
108MP0002092_abnormal_eye_morphology0.97021338
109MP0002086_abnormal_extraembryonic_tissu0.96030295
110MP0002572_abnormal_emotion/affect_behav0.94257643
111MP0001697_abnormal_embryo_size0.93833848
112MP0004808_abnormal_hematopoietic_stem0.92893922
113MP0002925_abnormal_cardiovascular_devel0.92871859
114MP0002557_abnormal_social/conspecific_i0.90117972
115MP0004811_abnormal_neuron_physiology0.89275751
116MP0002067_abnormal_sensory_capabilities0.89167946
117MP0001984_abnormal_olfaction0.89030228
118MP0001730_embryonic_growth_arrest0.88629912
119MP0002751_abnormal_autonomic_nervous0.88549695
120MP0001944_abnormal_pancreas_morphology0.87946672
121MP0002752_abnormal_somatic_nervous0.87762148
122MP0001485_abnormal_pinna_reflex0.87502801
123MP0010352_gastrointestinal_tract_polyps0.86691354
124MP0002082_postnatal_lethality0.85261033
125MP0010770_preweaning_lethality0.85261033
126MP0002108_abnormal_muscle_morphology0.85007612
127MP0002109_abnormal_limb_morphology0.84494489
128MP0005391_vision/eye_phenotype0.83907570
129MP0000955_abnormal_spinal_cord0.83890952
130MP0009250_abnormal_appendicular_skeleto0.82739398
131MP0005646_abnormal_pituitary_gland0.81902232
132MP0008569_lethality_at_weaning0.80303829
133MP0001849_ear_inflammation0.79755048
134MP0002177_abnormal_outer_ear0.77067494
135MP0002882_abnormal_neuron_morphology0.76782734
136MP0002234_abnormal_pharynx_morphology0.76446109
137MP0008058_abnormal_DNA_repair0.74358643

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.59969407
2Short 4th metacarpal (HP:0010044)3.59969407
3Volvulus (HP:0002580)3.41458493
4Hyperventilation (HP:0002883)3.20325073
5Macroorchidism (HP:0000053)2.87197876
6Abnormality of the fingertips (HP:0001211)2.80213834
7Trigonocephaly (HP:0000243)2.69115467
8Asymmetry of the thorax (HP:0001555)2.64928474
9Neoplasm of the adrenal cortex (HP:0100641)2.59709625
10Long eyelashes (HP:0000527)2.58320479
11Midline defect of the nose (HP:0004122)2.54627362
12Abnormality of the 4th metacarpal (HP:0010012)2.54539927
13Anal stenosis (HP:0002025)2.54231967
14Obsessive-compulsive behavior (HP:0000722)2.51930118
15Abnormality of the ischium (HP:0003174)2.50798351
16Supernumerary ribs (HP:0005815)2.44608812
17Hypoplastic ischia (HP:0003175)2.42342108
18Intestinal atresia (HP:0011100)2.41924777
19Increased nuchal translucency (HP:0010880)2.41251412
20Narrow palate (HP:0000189)2.38623889
21Astrocytoma (HP:0009592)2.36235416
22Abnormality of the astrocytes (HP:0100707)2.36235416
23Renal duplication (HP:0000075)2.35652521
24Abnormality of the labia minora (HP:0012880)2.23122862
25Progressive cerebellar ataxia (HP:0002073)2.20032484
26Cutaneous finger syndactyly (HP:0010554)2.19682575
27Genetic anticipation (HP:0003743)2.18787702
28Enlarged penis (HP:0000040)2.17516544
29Urethral obstruction (HP:0000796)2.17213792
30Chromsome breakage (HP:0040012)2.15649686
31Obstructive sleep apnea (HP:0002870)2.15571295
32Ependymoma (HP:0002888)2.14808064
33Abnormality of the nasal septum (HP:0000419)2.14257203
34Supernumerary bones of the axial skeleton (HP:0009144)2.13590632
35Abnormal number of incisors (HP:0011064)2.09921602
36Hypoplasia of the maxilla (HP:0000327)2.09663583
37Hyperacusis (HP:0010780)2.09615072
38Glioma (HP:0009733)2.07673197
39Broad thumb (HP:0011304)2.03689070
40Gaze-evoked nystagmus (HP:0000640)2.03280909
41Neoplasm of the oral cavity (HP:0100649)2.01697835
42Hepatoblastoma (HP:0002884)2.01337689
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01287547
44Fibular aplasia (HP:0002990)2.00799698
45Abnormality of the phalanges of the hallux (HP:0010057)1.97202737
46Shallow orbits (HP:0000586)1.96897002
47Medulloblastoma (HP:0002885)1.94844878
48Cutaneous syndactyly (HP:0012725)1.94162238
49Bronchomalacia (HP:0002780)1.93781420
50Drooling (HP:0002307)1.92101269
51Excessive salivation (HP:0003781)1.92101269
52Abnormality of the distal phalanx of the thumb (HP:0009617)1.91933502
53Cystic hygroma (HP:0000476)1.91547294
54Tented upper lip vermilion (HP:0010804)1.90655156
55Gastroesophageal reflux (HP:0002020)1.89073806
56Focal seizures (HP:0007359)1.88215380
57Abnormality of the aortic arch (HP:0012303)1.86790650
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86405635
59Sacral dimple (HP:0000960)1.85935910
60Thick eyebrow (HP:0000574)1.84397396
61Chronic hepatic failure (HP:0100626)1.83843185
62Absent speech (HP:0001344)1.81862393
63Laryngomalacia (HP:0001601)1.81758167
64Pointed chin (HP:0000307)1.81624687
65Papillary thyroid carcinoma (HP:0002895)1.80863507
66Tracheomalacia (HP:0002779)1.80499349
67Highly arched eyebrow (HP:0002553)1.80419311
68Abnormality of the labia majora (HP:0012881)1.79491095
69Abnormality of the parietal bone (HP:0002696)1.77960231
70Prominent nose (HP:0000448)1.77026648
71Renovascular hypertension (HP:0100817)1.76874364
72Tubulointerstitial nephritis (HP:0001970)1.76786349
73Abnormality of the diencephalon (HP:0010662)1.76056481
74Abnormality of the parathyroid morphology (HP:0011766)1.75869635
75Skull defect (HP:0001362)1.75519273
76Broad palm (HP:0001169)1.75507366
77Synophrys (HP:0000664)1.74960663
78Widely spaced teeth (HP:0000687)1.74628100
79Cutis marmorata (HP:0000965)1.74288250
80Smooth philtrum (HP:0000319)1.73679573
81Aplasia/Hypoplasia of the sternum (HP:0006714)1.73518359
82Truncal obesity (HP:0001956)1.73515779
83Elfin facies (HP:0004428)1.73206868
84Short philtrum (HP:0000322)1.73114420
85Increased number of teeth (HP:0011069)1.71508139
86Heterotopia (HP:0002282)1.71363643
87Neoplasm of striated muscle (HP:0009728)1.71334305
88Spina bifida occulta (HP:0003298)1.71148683
89Germ cell neoplasia (HP:0100728)1.71101150
90Protruding tongue (HP:0010808)1.71050376
91Attention deficit hyperactivity disorder (HP:0007018)1.70802962
92Ankyloglossia (HP:0010296)1.70393456
93Nephronophthisis (HP:0000090)1.70353128
94Lymphangioma (HP:0100764)1.69999992
95Facial hemangioma (HP:0000329)1.69566279
96Oligodactyly (hands) (HP:0001180)1.69416562
97Aqueductal stenosis (HP:0002410)1.69104562
98Transitional cell carcinoma of the bladder (HP:0006740)1.68991979
99Broad phalanges of the hand (HP:0009768)1.68823203
100Hypopigmentation of the fundus (HP:0007894)1.68763323
101Hypoplastic labia majora (HP:0000059)1.68515347
102Lip pit (HP:0100267)1.68198272
103Renal hypoplasia (HP:0000089)1.68055489
104Ectopic kidney (HP:0000086)1.68017724
105Abnormality of the pubic bones (HP:0003172)1.67303199
106Proximal placement of thumb (HP:0009623)1.66148729
107Abnormality of the renal medulla (HP:0100957)1.66122277
108Acute lymphatic leukemia (HP:0006721)1.65735655
109Leiomyosarcoma (HP:0100243)1.65688848
110Uterine leiomyosarcoma (HP:0002891)1.65688848
111Long clavicles (HP:0000890)1.65034769
112Neoplasm of the heart (HP:0100544)1.64215834
113Shawl scrotum (HP:0000049)1.64078278
114Partial agenesis of the corpus callosum (HP:0001338)1.63968032
115Abnormality of chromosome stability (HP:0003220)1.63246182
116Large earlobe (HP:0009748)1.62688517
117Dental malocclusion (HP:0000689)1.62289087
118Broad finger (HP:0001500)1.61735252
119Hamartoma (HP:0010566)1.61330376
120Cupped ear (HP:0000378)1.60408514
121Deviation of the thumb (HP:0009603)1.60102568
122Patellar dislocation (HP:0002999)1.59819128
123High anterior hairline (HP:0009890)1.58898626
124Abnormality of chromosome segregation (HP:0002916)1.58847054
125Blue irides (HP:0000635)1.58669145
126Epileptic encephalopathy (HP:0200134)1.58595773
127Sandal gap (HP:0001852)1.58309099
128Rib fusion (HP:0000902)1.57753666
129Overlapping toe (HP:0001845)1.57749915
130Low anterior hairline (HP:0000294)1.57637012
131Downturned corners of mouth (HP:0002714)1.57545757
132Abnormality of the intervertebral disk (HP:0005108)1.57268256
133Febrile seizures (HP:0002373)1.56188145
134Skin tags (HP:0010609)1.55999541
135Abnormality of the incisor (HP:0000676)1.55347399
136Hypoplastic iliac wings (HP:0002866)1.54588830
137Vesicoureteral reflux (HP:0000076)1.54519492
138Overriding aorta (HP:0002623)1.54140335
139Nephroblastoma (Wilms tumor) (HP:0002667)1.53781362
140Oligodontia (HP:0000677)1.53752304
141Hyperkalemia (HP:0002153)1.53562187
142Patellar aplasia (HP:0006443)1.52193608
143Bladder neoplasm (HP:0009725)1.51801364
144Bladder carcinoma (HP:0002862)1.51801364
145Bilateral microphthalmos (HP:0007633)1.50881415
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.50678641
147Deep philtrum (HP:0002002)1.50603226
148Oligodactyly (HP:0012165)1.50523219
149Broad-based gait (HP:0002136)1.50298274
150Autism (HP:0000717)1.50040905
151Hemiparesis (HP:0001269)1.49817507
152Labial hypoplasia (HP:0000066)1.48391331
153Intellectual disability, moderate (HP:0002342)1.47360374
154Blepharophimosis (HP:0000581)1.47270571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.42130242
2FRK3.88562239
3BRD43.56948816
4CDC72.93822023
5CASK2.88128665
6CAMK1G2.59883245
7SIK22.49741759
8CAMK1D2.26101549
9TNIK2.14392232
10MAP3K102.06015616
11LATS11.98784645
12NTRK31.98697904
13INSRR1.84164720
14SIK31.81870902
15FGFR21.78163768
16BRSK21.69741417
17KSR11.68742134
18NTRK21.67184686
19TYRO31.63131662
20MARK11.61852837
21PNCK1.58045806
22SGK21.53948898
23NLK1.52800411
24ICK1.46761028
25SGK31.43686246
26MAP3K41.37319813
27WEE11.28110141
28DMPK1.24696264
29DYRK1A1.24393164
30BMPR1B1.23725030
31FGFR31.22315196
32PDGFRA1.22187893
33MTOR1.20494530
34MARK21.20170837
35ACVR1B1.18194173
36EPHA31.16033507
37CAMK41.13582941
38FGFR11.11256699
39EPHA41.09769794
40ATR1.09141719
41MKNK11.08919551
42MKNK21.07186305
43ALK1.06292416
44CHEK11.04958736
45TAF11.03446931
46MAP3K91.01368671
47NUAK11.00643556
48PKN20.99557948
49LATS20.96773966
50MINK10.94643610
51ATM0.94109069
52YES10.94020209
53TNK20.93798882
54CDK30.92649916
55TRIB30.90888786
56NEK20.90881807
57CDK20.90608366
58WNK10.90566328
59CDK70.88998503
60PRKD30.88145974
61PAK30.87458283
62ERBB30.87193844
63PLK30.86757996
64WNK30.86722983
65DYRK1B0.85168373
66ERBB20.83320624
67CDC42BPA0.81663147
68RIPK10.81152800
69SGK4940.79219175
70SGK2230.79219175
71* CDK10.78782915
72CHEK20.78693558
73PDGFRB0.76912065
74* GSK3B0.76674000
75CDK90.76042464
76SRPK10.75675969
77MAPK100.74358461
78PAK60.73775763
79MAPK140.72858829
80SGK10.72457803
81PLK40.72345337
82CSNK1D0.71741007
83STK110.71609465
84MAPK70.71414611
85MELK0.70977734
86CSNK1A1L0.70493026
87MAP3K70.69272023
88* MAPK80.67749277
89CDK60.67554479
90CCNB10.67499477
91CDK40.66834891
92BRSK10.64896110
93UHMK10.64534649
94CSNK1E0.64422213
95SIK10.63905918
96STK380.63159706
97HIPK20.62252825
98PRPF4B0.61333371
99PRKAA10.61023645
100MAPK90.60305446
101STK38L0.59462290
102TTK0.59224234
103EEF2K0.58983706
104MAPK130.58659241
105PRKDC0.58005154
106AKT10.56986641
107AKT30.56412193
108EPHB20.56373054
109PRKD20.56301557
110FGFR40.56289432
111MAPK10.55396870
112AKT20.54225580
113CSNK1G20.53328489
114PLK20.53185713
115RPS6KA30.49477419
116RPS6KB10.49426233
117DYRK20.48332288
118STK30.47830709
119FER0.46879766
120PRKCZ0.46684131
121CSNK1G10.45922761
122CHUK0.45688420
123CAMK10.45066568
124STK390.44213680
125DAPK20.43839341
126PRKAA20.42774555
127CAMKK10.42578454
128PKN10.42330703
129PASK0.41553523
130PRKCH0.40958005
131IRAK10.40496039
132CDK50.40347757
133TRIM280.40053378
134DDR20.39547780

Predicted pathways (KEGG)

RankGene SetZ-score
1mRNA surveillance pathway_Homo sapiens_hsa030151.91632146
2Basal cell carcinoma_Homo sapiens_hsa052171.78128516
3Nicotine addiction_Homo sapiens_hsa050331.66487571
4Long-term potentiation_Homo sapiens_hsa047201.58801767
5Wnt signaling pathway_Homo sapiens_hsa043101.54096153
6Thyroid hormone signaling pathway_Homo sapiens_hsa049191.47295080
7Hedgehog signaling pathway_Homo sapiens_hsa043401.46937198
8Lysine degradation_Homo sapiens_hsa003101.43787406
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41986726
10Colorectal cancer_Homo sapiens_hsa052101.39913956
11Circadian entrainment_Homo sapiens_hsa047131.38119326
12MicroRNAs in cancer_Homo sapiens_hsa052061.37683090
13Notch signaling pathway_Homo sapiens_hsa043301.35877069
14Endometrial cancer_Homo sapiens_hsa052131.35374649
15Hippo signaling pathway_Homo sapiens_hsa043901.35032361
16mTOR signaling pathway_Homo sapiens_hsa041501.35026275
17Phototransduction_Homo sapiens_hsa047441.34748322
18Axon guidance_Homo sapiens_hsa043601.34189127
19Adherens junction_Homo sapiens_hsa045201.29251571
20Glutamatergic synapse_Homo sapiens_hsa047241.26235354
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23779877
22Cell cycle_Homo sapiens_hsa041101.22587890
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.21548043
24Glioma_Homo sapiens_hsa052141.20128530
25Chronic myeloid leukemia_Homo sapiens_hsa052201.20060474
26Amphetamine addiction_Homo sapiens_hsa050311.19763143
27Dorso-ventral axis formation_Homo sapiens_hsa043201.16868635
28ErbB signaling pathway_Homo sapiens_hsa040121.16718239
29Dopaminergic synapse_Homo sapiens_hsa047281.14936408
30Melanogenesis_Homo sapiens_hsa049161.14674508
31Morphine addiction_Homo sapiens_hsa050321.14084345
32Cocaine addiction_Homo sapiens_hsa050301.12869946
33Circadian rhythm_Homo sapiens_hsa047101.12324318
34Non-small cell lung cancer_Homo sapiens_hsa052231.12033570
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11562725
36Spliceosome_Homo sapiens_hsa030401.11123055
37Type II diabetes mellitus_Homo sapiens_hsa049301.10875029
38Cholinergic synapse_Homo sapiens_hsa047251.10325925
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09285478
40Olfactory transduction_Homo sapiens_hsa047401.09253825
41Oocyte meiosis_Homo sapiens_hsa041141.08764031
42Long-term depression_Homo sapiens_hsa047301.08457694
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08239360
44RNA transport_Homo sapiens_hsa030131.07822598
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07788599
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07489393
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06235795
48ABC transporters_Homo sapiens_hsa020101.04885174
49Oxytocin signaling pathway_Homo sapiens_hsa049211.04708141
50GABAergic synapse_Homo sapiens_hsa047271.04707592
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04118144
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.03921905
53Tight junction_Homo sapiens_hsa045301.03475171
54MAPK signaling pathway_Homo sapiens_hsa040101.00827611
55Insulin secretion_Homo sapiens_hsa049111.00466798
56Renal cell carcinoma_Homo sapiens_hsa052111.00444453
57Taste transduction_Homo sapiens_hsa047420.99660418
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98390635
59Prostate cancer_Homo sapiens_hsa052150.98153359
60Gap junction_Homo sapiens_hsa045400.97135692
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95801313
62Proteoglycans in cancer_Homo sapiens_hsa052050.94956577
63TGF-beta signaling pathway_Homo sapiens_hsa043500.94630695
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94479816
65Renin secretion_Homo sapiens_hsa049240.94117096
66Estrogen signaling pathway_Homo sapiens_hsa049150.93665948
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92934088
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92020617
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91984905
70Thyroid hormone synthesis_Homo sapiens_hsa049180.91973694
71Glucagon signaling pathway_Homo sapiens_hsa049220.91724337
72cAMP signaling pathway_Homo sapiens_hsa040240.91453757
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88837080
74HTLV-I infection_Homo sapiens_hsa051660.88534027
75Pathways in cancer_Homo sapiens_hsa052000.87937211
76Ovarian steroidogenesis_Homo sapiens_hsa049130.87741399
77Pancreatic cancer_Homo sapiens_hsa052120.86347553
78GnRH signaling pathway_Homo sapiens_hsa049120.85802668
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85309993
80Prolactin signaling pathway_Homo sapiens_hsa049170.84660349
81Choline metabolism in cancer_Homo sapiens_hsa052310.84234693
82FoxO signaling pathway_Homo sapiens_hsa040680.84215841
83Butanoate metabolism_Homo sapiens_hsa006500.83537509
84AMPK signaling pathway_Homo sapiens_hsa041520.83530606
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81660006
86Rap1 signaling pathway_Homo sapiens_hsa040150.81431768
87RNA degradation_Homo sapiens_hsa030180.81403547
88Salivary secretion_Homo sapiens_hsa049700.80510731
89T cell receptor signaling pathway_Homo sapiens_hsa046600.79295463
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.78922085
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77839037
92Gastric acid secretion_Homo sapiens_hsa049710.75570402
93Fanconi anemia pathway_Homo sapiens_hsa034600.74970065
94Insulin signaling pathway_Homo sapiens_hsa049100.74829346
95Serotonergic synapse_Homo sapiens_hsa047260.74356694
96Acute myeloid leukemia_Homo sapiens_hsa052210.73933443
97Calcium signaling pathway_Homo sapiens_hsa040200.73773321
98Dilated cardiomyopathy_Homo sapiens_hsa054140.72960170
99Small cell lung cancer_Homo sapiens_hsa052220.71406512
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70783413
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70507123
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70412957
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.70380158
104Insulin resistance_Homo sapiens_hsa049310.70259661
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69842834
106Inositol phosphate metabolism_Homo sapiens_hsa005620.69331916
107Melanoma_Homo sapiens_hsa052180.69019796
108Pancreatic secretion_Homo sapiens_hsa049720.66274673
109Thyroid cancer_Homo sapiens_hsa052160.65975915
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65313635
111Viral myocarditis_Homo sapiens_hsa054160.65172937
112VEGF signaling pathway_Homo sapiens_hsa043700.65004964
113B cell receptor signaling pathway_Homo sapiens_hsa046620.64816162
114Hepatitis B_Homo sapiens_hsa051610.64122265
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63621769
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.63364549
117Non-homologous end-joining_Homo sapiens_hsa034500.62829021
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62739529
119Ras signaling pathway_Homo sapiens_hsa040140.60417054
120Ether lipid metabolism_Homo sapiens_hsa005650.57676601
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56550816
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56477681
123Bile secretion_Homo sapiens_hsa049760.55509626
124Propanoate metabolism_Homo sapiens_hsa006400.55132233
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52137191

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