POLA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA strand elongation involved in DNA replication (GO:0006271)5.04721954
2DNA unwinding involved in DNA replication (GO:0006268)5.00789366
3* telomere maintenance via semi-conservative replication (GO:0032201)4.95655050
4protein localization to kinetochore (GO:0034501)4.94137639
5* DNA replication initiation (GO:0006270)4.85316165
6DNA replication checkpoint (GO:0000076)4.83778634
7* DNA strand elongation (GO:0022616)4.80853830
8kinetochore organization (GO:0051383)4.62568418
9* telomere maintenance via recombination (GO:0000722)4.61045093
10* mitotic recombination (GO:0006312)4.58043575
11CENP-A containing nucleosome assembly (GO:0034080)4.45663390
12chromatin remodeling at centromere (GO:0031055)4.44836500
13nuclear pore organization (GO:0006999)4.37679125
14nuclear pore complex assembly (GO:0051292)4.28567606
15mitotic chromosome condensation (GO:0007076)4.20687723
16protein localization to chromosome, centromeric region (GO:0071459)4.19437164
17DNA replication-dependent nucleosome assembly (GO:0006335)4.19062249
18DNA replication-dependent nucleosome organization (GO:0034723)4.19062249
19mitotic metaphase plate congression (GO:0007080)4.16942937
20DNA replication-independent nucleosome assembly (GO:0006336)4.15645461
21DNA replication-independent nucleosome organization (GO:0034724)4.15645461
22establishment of integrated proviral latency (GO:0075713)4.11965131
23meiotic chromosome segregation (GO:0045132)4.01236920
24kinetochore assembly (GO:0051382)4.01080217
25* telomere maintenance via telomere lengthening (GO:0010833)3.99889724
26DNA ligation (GO:0006266)3.95701737
27metaphase plate congression (GO:0051310)3.88263218
28mitotic sister chromatid segregation (GO:0000070)3.81721490
29mitotic nuclear envelope disassembly (GO:0007077)3.81152759
30sister chromatid segregation (GO:0000819)3.80391695
31attachment of spindle microtubules to kinetochore (GO:0008608)3.77645400
32* double-strand break repair via nonhomologous end joining (GO:0006303)3.76040687
33* non-recombinational repair (GO:0000726)3.76040687
34* nucleotide-excision repair, DNA gap filling (GO:0006297)3.72267219
35chromosome condensation (GO:0030261)3.70971098
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.69980138
37histone exchange (GO:0043486)3.69069020
38IMP biosynthetic process (GO:0006188)3.62425841
39mitotic sister chromatid cohesion (GO:0007064)3.62367475
40DNA geometric change (GO:0032392)3.61945695
41DNA duplex unwinding (GO:0032508)3.60769228
42* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59710806
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.58157620
44nucleobase biosynthetic process (GO:0046112)3.57432793
45establishment of chromosome localization (GO:0051303)3.57382868
46heterochromatin organization (GO:0070828)3.56936215
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.52561498
48nuclear envelope disassembly (GO:0051081)3.49772600
49membrane disassembly (GO:0030397)3.49772600
50regulation of mitotic spindle organization (GO:0060236)3.49156883
51regulation of translational fidelity (GO:0006450)3.47642674
52protein K6-linked ubiquitination (GO:0085020)3.45750411
53pore complex assembly (GO:0046931)3.44754108
54chromatin assembly or disassembly (GO:0006333)3.44006682
55regulation of centrosome duplication (GO:0010824)3.43211490
56mismatch repair (GO:0006298)3.42569985
57DNA packaging (GO:0006323)3.41987581
58* telomere maintenance (GO:0000723)3.39534803
59* telomere organization (GO:0032200)3.37713336
60purine nucleobase biosynthetic process (GO:0009113)3.34249678
61regulation of helicase activity (GO:0051095)3.34118734
62regulation of histone H3-K9 methylation (GO:0051570)3.30458444
63pre-miRNA processing (GO:0031054)3.29816062
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.29590234
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29590234
66regulation of double-strand break repair via homologous recombination (GO:0010569)3.29545315
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29277015
68regulation of centrosome cycle (GO:0046605)3.29250789
69regulation of centriole replication (GO:0046599)3.27676776
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27364296
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.26912866
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.26912866
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.26912866
74regulation of spindle organization (GO:0090224)3.25836700
75folic acid-containing compound biosynthetic process (GO:0009396)3.24697220
76spindle checkpoint (GO:0031577)3.24095286
77chromosome segregation (GO:0007059)3.24046095
78protein complex localization (GO:0031503)3.23836347
79nuclear envelope organization (GO:0006998)3.21428443
80sister chromatid cohesion (GO:0007062)3.19459597
81IMP metabolic process (GO:0046040)3.18317808
82replication fork processing (GO:0031297)3.18070583
83regulation of RNA export from nucleus (GO:0046831)3.16923568
84ribosomal small subunit assembly (GO:0000028)3.15935613
85spindle assembly checkpoint (GO:0071173)3.15718900
86chromatin assembly (GO:0031497)3.14845655
87protein localization to chromosome (GO:0034502)3.13706629
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13599990
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13405613
90intra-S DNA damage checkpoint (GO:0031573)3.13129006
91regulation of chromosome segregation (GO:0051983)3.12219201
92negative regulation of chromosome segregation (GO:0051985)3.11845481
93DNA conformation change (GO:0071103)3.11768000
94positive regulation of chromosome segregation (GO:0051984)3.11258563
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10422388
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10422388
97negative regulation of sister chromatid segregation (GO:0033046)3.10422388
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.10422388
99regulation of DNA endoreduplication (GO:0032875)3.09240371
100ATP-dependent chromatin remodeling (GO:0043044)3.08591206
101mitotic G2/M transition checkpoint (GO:0044818)3.08213866
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06406169
103DNA double-strand break processing (GO:0000729)3.05586616
104DNA topological change (GO:0006265)3.04759431
105mitotic spindle assembly checkpoint (GO:0007094)3.02212062
106ribosome assembly (GO:0042255)3.01295838
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01206196
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00923828
109maturation of SSU-rRNA (GO:0030490)2.98202305
110* DNA synthesis involved in DNA repair (GO:0000731)2.98190635
111dosage compensation (GO:0007549)2.97055251
112* DNA replication (GO:0006260)2.96856910
113regulation of mitotic sister chromatid separation (GO:0010965)2.96177813
114regulation of mitotic sister chromatid segregation (GO:0033047)2.96177813
115regulation of sister chromatid segregation (GO:0033045)2.96177813
116mitotic spindle checkpoint (GO:0071174)2.95426813
117* translesion synthesis (GO:0019985)2.93128398
118regulation of sister chromatid cohesion (GO:0007063)2.92713156
119DNA deamination (GO:0045006)2.92313951
120formation of translation preinitiation complex (GO:0001731)2.91836488
121ribosome biogenesis (GO:0042254)2.90190614

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.20486898
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.69682588
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.77873423
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.66949729
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82163413
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81054065
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59976627
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59969837
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.52431794
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.45202289
11AR_21909140_ChIP-Seq_LNCAP_Human2.36375368
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32353832
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.31535211
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26169048
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25050248
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.20649618
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16178295
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.12850577
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12660203
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10651899
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09742409
22VDR_23849224_ChIP-Seq_CD4+_Human2.05515788
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03031394
24* E2F7_22180533_ChIP-Seq_HELA_Human11.5182913
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98341537
26XRN2_22483619_ChIP-Seq_HELA_Human1.93860807
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93634791
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92458747
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.85299163
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83614251
31FOXP3_21729870_ChIP-Seq_TREG_Human1.81870612
32ELK1_19687146_ChIP-ChIP_HELA_Human1.81642623
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74631992
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73563369
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69850806
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67879925
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67472440
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66471519
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65060841
40DCP1A_22483619_ChIP-Seq_HELA_Human1.60830472
41TTF2_22483619_ChIP-Seq_HELA_Human1.58532185
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56352268
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56330806
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51463473
45CIITA_25753668_ChIP-Seq_RAJI_Human1.49845587
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48848701
47GABP_19822575_ChIP-Seq_HepG2_Human1.46518713
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46313967
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.42366882
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42243636
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41913512
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37328008
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36064921
54MYC_22102868_ChIP-Seq_BL_Human1.35505032
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35375469
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31528472
57KDM5A_27292631_Chip-Seq_BREAST_Human1.30420080
58* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30417247
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29517469
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28195526
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28148281
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28069688
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25934952
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24078743
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23589202
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14168988
67* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12308345
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.10683307
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07662106
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07338345
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04818014
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04158936
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.03115999
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02807423
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02696411
76SOX17_20123909_ChIP-Seq_XEN_Mouse1.00243309
77TFEB_21752829_ChIP-Seq_HELA_Human0.99754262
78MYC_18940864_ChIP-ChIP_HL60_Human0.99032763
79NOTCH1_21737748_ChIP-Seq_TLL_Human0.98762142
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95784945
81SPI1_23547873_ChIP-Seq_NB4_Human0.95444799
82STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93479226
83KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93422276
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92854587
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92439213
86CHD1_26751641_Chip-Seq_LNCaP_Human0.92021047
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90831545
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89466952
89EWS_26573619_Chip-Seq_HEK293_Human0.88589047
90FUS_26573619_Chip-Seq_HEK293_Human0.85829374
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85162490
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84583286
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.81478999
94* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81127231
95VDR_21846776_ChIP-Seq_THP-1_Human0.81116667
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78331567
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76829729
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76829729
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76829729
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75412668
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74109141
102ZNF263_19887448_ChIP-Seq_K562_Human0.73127312
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.73051487
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.72243552
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71304235
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71095430
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70446725
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.69752166
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.68819438
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.67796168
111POU5F1_16153702_ChIP-ChIP_HESCs_Human0.67357615
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.64064843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.91933540
2MP0003693_abnormal_embryo_hatching4.88930540
3MP0008057_abnormal_DNA_replication4.58547372
4MP0003111_abnormal_nucleus_morphology4.42517550
5MP0003077_abnormal_cell_cycle3.89631947
6MP0004957_abnormal_blastocyst_morpholog3.65062037
7MP0008058_abnormal_DNA_repair3.56629397
8MP0002396_abnormal_hematopoietic_system2.90537928
9MP0008007_abnormal_cellular_replicative2.80222842
10MP0008932_abnormal_embryonic_tissue2.53697973
11MP0010307_abnormal_tumor_latency2.51616139
12MP0000350_abnormal_cell_proliferation2.17208402
13MP0010352_gastrointestinal_tract_polyps2.11867826
14MP0008877_abnormal_DNA_methylation2.07631975
15MP0003786_premature_aging1.99109787
16MP0001730_embryonic_growth_arrest1.89258536
17MP0000490_abnormal_crypts_of1.82864248
18MP0004808_abnormal_hematopoietic_stem1.74268452
19MP0009672_abnormal_birth_weight1.69810221
20MP0003123_paternal_imprinting1.63614938
21MP0005076_abnormal_cell_differentiation1.61895612
22MP0003121_genomic_imprinting1.58947797
23MP0005380_embryogenesis_phenotype1.58908247
24MP0001672_abnormal_embryogenesis/_devel1.58908247
25MP0001697_abnormal_embryo_size1.48701807
26MP0003890_abnormal_embryonic-extraembry1.46434531
27MP0002085_abnormal_embryonic_tissue1.46020761
28MP0003984_embryonic_growth_retardation1.41249302
29MP0000313_abnormal_cell_death1.39924497
30MP0002019_abnormal_tumor_incidence1.38640988
31MP0006292_abnormal_olfactory_placode1.38244881
32MP0002088_abnormal_embryonic_growth/wei1.37194960
33MP0002084_abnormal_developmental_patter1.35538570
34MP0004197_abnormal_fetal_growth/weight/1.35396640
35MP0001293_anophthalmia1.35001904
36MP0002080_prenatal_lethality1.32373639
37MP0002877_abnormal_melanocyte_morpholog1.31938345
38MP0000569_abnormal_digit_pigmentation1.28650972
39MP0002086_abnormal_extraembryonic_tissu1.26216848
40MP0004233_abnormal_muscle_weight1.24571239
41MP0001346_abnormal_lacrimal_gland1.22400995
42MP0000703_abnormal_thymus_morphology1.19354223
43MP0001661_extended_life_span1.17284387
44MP0003567_abnormal_fetal_cardiomyocyte1.16234959
45MP0002210_abnormal_sex_determination1.12630796
46MP0001545_abnormal_hematopoietic_system1.12335223
47MP0005397_hematopoietic_system_phenotyp1.12335223
48MP0010030_abnormal_orbit_morphology1.12173390
49MP0003315_abnormal_perineum_morphology1.10239951
50MP0004185_abnormal_adipocyte_glucose1.07958622
51MP0010234_abnormal_vibrissa_follicle1.07282820
52MP0003763_abnormal_thymus_physiology1.07251382
53MP0002398_abnormal_bone_marrow1.07177349
54MP0003705_abnormal_hypodermis_morpholog1.06340062
55MP0003718_maternal_effect1.05798718
56MP0002233_abnormal_nose_morphology0.98871381
57MP0002722_abnormal_immune_system0.97825909
58MP0003937_abnormal_limbs/digits/tail_de0.97323619
59MP0002095_abnormal_skin_pigmentation0.96641581
60MP0000371_diluted_coat_color0.95563085
61MP0000358_abnormal_cell_content/0.94821946
62MP0006035_abnormal_mitochondrial_morpho0.93471801
63MP0000689_abnormal_spleen_morphology0.93461572
64MP0001145_abnormal_male_reproductive0.92800853
65MP0006054_spinal_hemorrhage0.91382338
66MP0001119_abnormal_female_reproductive0.91036906
67MP0005174_abnormal_tail_pigmentation0.91021862
68MP0009333_abnormal_splenocyte_physiolog0.89814228
69MP0000566_synostosis0.89699241
70MP0002075_abnormal_coat/hair_pigmentati0.87793470
71MP0009053_abnormal_anal_canal0.87091211
72MP0000015_abnormal_ear_pigmentation0.87016069
73MP0002006_tumorigenesis0.86969391
74MP0005075_abnormal_melanosome_morpholog0.84967433
75MP0003385_abnormal_body_wall0.84604786
76MP0009278_abnormal_bone_marrow0.83132354
77MP0001929_abnormal_gametogenesis0.82234582
78MP0003935_abnormal_craniofacial_develop0.81854591
79MP0001835_abnormal_antigen_presentation0.81633411
80MP0002092_abnormal_eye_morphology0.80656084
81MP0003861_abnormal_nervous_system0.80072227
82MP0005384_cellular_phenotype0.79467560
83MP0000653_abnormal_sex_gland0.78766904
84MP0000537_abnormal_urethra_morphology0.78378342
85MP0002429_abnormal_blood_cell0.77949521
86MP0005621_abnormal_cell_physiology0.77908008
87MP0003221_abnormal_cardiomyocyte_apopto0.77610997
88MP0004133_heterotaxia0.77604726
89MP0000579_abnormal_nail_morphology0.77560668
90MP0000428_abnormal_craniofacial_morphol0.77109347
91MP0001186_pigmentation_phenotype0.77045402
92MP0002102_abnormal_ear_morphology0.76629614
93MP0003119_abnormal_digestive_system0.76519371
94MP0002938_white_spotting0.76325099
95MP0003943_abnormal_hepatobiliary_system0.76305026
96MP0000858_altered_metastatic_potential0.75806151
97MP0002160_abnormal_reproductive_system0.75567381
98MP0002111_abnormal_tail_morphology0.75564697
99MP0009703_decreased_birth_body0.75417303
100MP0005389_reproductive_system_phenotype0.73621857
101MP0001286_abnormal_eye_development0.73186470
102MP0003941_abnormal_skin_development0.72920960
103MP0002234_abnormal_pharynx_morphology0.70544567
104MP0000383_abnormal_hair_follicle0.70416473
105MP0001915_intracranial_hemorrhage0.68452132
106MP0000716_abnormal_immune_system0.68295809
107MP0003699_abnormal_female_reproductive0.67550772
108MP0004147_increased_porphyrin_level0.67147320
109MP0002166_altered_tumor_susceptibility0.66072300
110MP0002697_abnormal_eye_size0.65984890
111MP0003755_abnormal_palate_morphology0.65970390
112MP0003950_abnormal_plasma_membrane0.65474056
113MP0005023_abnormal_wound_healing0.65182590
114MP0003787_abnormal_imprinting0.64942012
115MP0002114_abnormal_axial_skeleton0.63341583
116MP0003136_yellow_coat_color0.63118692
117MP0001800_abnormal_humoral_immune0.62776859
118MP0003115_abnormal_respiratory_system0.62066296
119MP0005187_abnormal_penis_morphology0.62030112
120MP0003448_altered_tumor_morphology0.61841042
121MP0000432_abnormal_head_morphology0.61800028
122MP0010678_abnormal_skin_adnexa0.59393264
123MP0005623_abnormal_meninges_morphology0.59143106
124MP0002277_abnormal_respiratory_mucosa0.59063814
125MP0009697_abnormal_copulation0.58846288
126MP0005671_abnormal_response_to0.58548545
127MP0002009_preneoplasia0.57756973
128MP0002452_abnormal_antigen_presenting0.57122263
129MP0000647_abnormal_sebaceous_gland0.57088493
130MP0005391_vision/eye_phenotype0.56753989
131MP0002420_abnormal_adaptive_immunity0.56651863
132MP0002081_perinatal_lethality0.56645408
133MP0005501_abnormal_skin_physiology0.55657307
134MP0002161_abnormal_fertility/fecundity0.55574507
135MP0001299_abnormal_eye_distance/0.54152507
136MP0004264_abnormal_extraembryonic_tissu0.53031370
137MP0003698_abnormal_male_reproductive0.52209323
138MP0002163_abnormal_gland_morphology0.51717020

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.72783168
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.61717353
3Birth length less than 3rd percentile (HP:0003561)4.47067284
4* Abnormality of chromosome stability (HP:0003220)3.94614949
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.92326100
6Meckel diverticulum (HP:0002245)3.71118959
7Reticulocytopenia (HP:0001896)3.69450093
8Abnormality of the preputium (HP:0100587)3.63678355
9Abnormality of the ileum (HP:0001549)3.56065139
10Patellar aplasia (HP:0006443)3.26953621
11Medulloblastoma (HP:0002885)3.16815229
12Ependymoma (HP:0002888)3.13573547
13Colon cancer (HP:0003003)3.11731773
14Small intestinal stenosis (HP:0012848)3.11247479
15Duodenal stenosis (HP:0100867)3.11247479
16Ectopic kidney (HP:0000086)3.08395060
17Breast hypoplasia (HP:0003187)3.05504861
18Impulsivity (HP:0100710)3.05002492
19Duplicated collecting system (HP:0000081)3.04661547
20Selective tooth agenesis (HP:0001592)3.02844238
21Aplasia/Hypoplasia of the patella (HP:0006498)3.01392276
22Myelodysplasia (HP:0002863)2.97917893
23Agnosia (HP:0010524)2.92354833
24Abnormality of the anterior horn cell (HP:0006802)2.82759104
25Degeneration of anterior horn cells (HP:0002398)2.82759104
26Abnormality of the renal collecting system (HP:0004742)2.82399485
27Abnormal number of incisors (HP:0011064)2.79508697
28Volvulus (HP:0002580)2.74367274
29Cortical dysplasia (HP:0002539)2.72341261
30Clubbing of toes (HP:0100760)2.71854874
31Abnormality of the carotid arteries (HP:0005344)2.70835720
32Absent radius (HP:0003974)2.64849494
33Bone marrow hypocellularity (HP:0005528)2.63291851
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62073492
35Oral leukoplakia (HP:0002745)2.61802083
36Abnormality of the labia minora (HP:0012880)2.61384481
37Abnormality of the duodenum (HP:0002246)2.60907086
38Carpal bone hypoplasia (HP:0001498)2.60171627
39Abnormality of cochlea (HP:0000375)2.54458471
40Sloping forehead (HP:0000340)2.52116782
41Glioma (HP:0009733)2.49453082
42Absent thumb (HP:0009777)2.46423560
43Rhabdomyosarcoma (HP:0002859)2.44312932
44Aplasia involving forearm bones (HP:0009822)2.44020088
45Absent forearm bone (HP:0003953)2.44020088
46High anterior hairline (HP:0009890)2.37537856
47Increased nuchal translucency (HP:0010880)2.32784871
48Aplastic anemia (HP:0001915)2.29118741
49Neoplasm of the pancreas (HP:0002894)2.28943059
5011 pairs of ribs (HP:0000878)2.28682844
51Premature graying of hair (HP:0002216)2.27406777
52Tracheoesophageal fistula (HP:0002575)2.26128669
53Multiple enchondromatosis (HP:0005701)2.25954043
54Triphalangeal thumb (HP:0001199)2.25619046
55Short thumb (HP:0009778)2.23800914
56Astrocytoma (HP:0009592)2.22119652
57Abnormality of the astrocytes (HP:0100707)2.22119652
58Prominent nose (HP:0000448)2.22112271
59IgM deficiency (HP:0002850)2.21626923
60Cafe-au-lait spot (HP:0000957)2.14960886
61Microvesicular hepatic steatosis (HP:0001414)2.13391186
62Abnormality of cells of the erythroid lineage (HP:0012130)2.13045333
63Abnormal number of erythroid precursors (HP:0012131)2.12848160
64Rough bone trabeculation (HP:0100670)2.12199061
65Lymphoma (HP:0002665)2.09905417
66Nephroblastoma (Wilms tumor) (HP:0002667)2.09167098
67Proximal placement of thumb (HP:0009623)2.08717062
68Supernumerary spleens (HP:0009799)2.05655421
69Abnormality of DNA repair (HP:0003254)2.04291481
70Duplication of thumb phalanx (HP:0009942)2.03283617
71Facial cleft (HP:0002006)2.03179975
72Horseshoe kidney (HP:0000085)2.03005772
73Overlapping toe (HP:0001845)2.02011125
74Deviation of the thumb (HP:0009603)2.01500485
75Progressive muscle weakness (HP:0003323)2.00159393
76Abnormal lung lobation (HP:0002101)1.98898003
77Sandal gap (HP:0001852)1.98560086
78Neoplasm of the oral cavity (HP:0100649)1.97533239
79Amaurosis fugax (HP:0100576)1.97420965
80Prostate neoplasm (HP:0100787)1.96130564
81Cellular immunodeficiency (HP:0005374)1.96042098
82Missing ribs (HP:0000921)1.95066076
83High pitched voice (HP:0001620)1.94699676
84Embryonal neoplasm (HP:0002898)1.94173400
85Progressive external ophthalmoplegia (HP:0000590)1.94056118
86Aplasia/Hypoplasia of the earlobes (HP:0009906)1.92999856
87Embryonal renal neoplasm (HP:0011794)1.91974961
88Abnormality of the fingertips (HP:0001211)1.91111177
89Acute lymphatic leukemia (HP:0006721)1.90225646
90Biliary tract neoplasm (HP:0100574)1.88776921
91Neoplasm of the colon (HP:0100273)1.87865218
92Spinal muscular atrophy (HP:0007269)1.86297475
93Long eyelashes (HP:0000527)1.84603091
94Facial hemangioma (HP:0000329)1.84127427
95Basal cell carcinoma (HP:0002671)1.81561103
96Abnormality of the calcaneus (HP:0008364)1.81204392
97Morphological abnormality of the inner ear (HP:0011390)1.79810900
98Acute myeloid leukemia (HP:0004808)1.79397080
99Atresia of the external auditory canal (HP:0000413)1.79374270
100Arteriovenous malformation (HP:0100026)1.79128863
101Pallor (HP:0000980)1.78263321
102Anal stenosis (HP:0002025)1.77959716
103Leukopenia (HP:0001882)1.77496898
104Microglossia (HP:0000171)1.75812528
105Obsessive-compulsive behavior (HP:0000722)1.74304662
106Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72424360
107Squamous cell carcinoma (HP:0002860)1.72185632
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70637838
109Short 4th metacarpal (HP:0010044)1.70637838
110Deep philtrum (HP:0002002)1.69979981
111Slender long bone (HP:0003100)1.69918496
112Microretrognathia (HP:0000308)1.68856524
113Microtia (HP:0008551)1.66918876
114Abnormality of abdominal situs (HP:0011620)1.66366174
115Abdominal situs inversus (HP:0003363)1.66366174
116Calcaneovalgus deformity (HP:0001848)1.65931283
117Abnormality of chromosome segregation (HP:0002916)1.65857242
118Premature ovarian failure (HP:0008209)1.65570910
119Neoplasm of striated muscle (HP:0009728)1.65339394
120Abnormality of glycolysis (HP:0004366)1.65226569
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.64818309
122Hypoplasia of the pons (HP:0012110)1.64760450
123Choanal atresia (HP:0000453)1.64639131
124Single umbilical artery (HP:0001195)1.63991100
125Abnormality of the fetal cardiovascular system (HP:0010948)1.63991100
126Abnormal umbilical cord blood vessels (HP:0011403)1.63991100
127Gastrointestinal carcinoma (HP:0002672)1.63888583
128Malignant gastrointestinal tract tumors (HP:0006749)1.63888583
129Long clavicles (HP:0000890)1.62958931
130Overriding aorta (HP:0002623)1.62474536
131Spastic diplegia (HP:0001264)1.62457496
132Abnormality of the pons (HP:0007361)1.61960332
133Septate vagina (HP:0001153)1.60449417
134Short middle phalanx of the 5th finger (HP:0004220)1.52179096
135Neoplasm of the adrenal cortex (HP:0100641)1.49744675
136Abnormality of the umbilical cord (HP:0010881)1.49677920
137Abnormal foot bone ossification (HP:0010675)1.48814620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.77807922
2WEE14.07541919
3BUB13.40562001
4EIF2AK13.14239029
5SRPK13.04299699
6TTK2.92085259
7PLK42.80157084
8ZAK2.68732156
9NEK22.65577667
10EIF2AK32.62634105
11ATR2.26120701
12ACVR1B2.25198210
13PLK12.08915144
14TLK12.06957941
15VRK11.98346451
16BRSK21.95108297
17AURKB1.89587918
18MKNK11.84024250
19NEK11.80150321
20PASK1.79671317
21CDK121.79024235
22CHEK21.73991050
23PLK31.71454898
24TSSK61.70239831
25TAF11.63648981
26PDK21.61116612
27STK41.60772443
28CDK71.59828089
29RPS6KB21.49980640
30DYRK31.43531260
31STK161.42240795
32CCNB11.34382087
33CHEK11.34350461
34MKNK21.32192077
35CDK41.30757899
36EEF2K1.29879584
37SMG11.24918985
38SIK31.20032510
39EPHA21.18832657
40RPS6KA41.18070017
41VRK21.17402038
42MAP3K81.15531069
43ATM1.15295403
44BRD41.15172006
45EIF2AK21.14352438
46BRSK11.10112495
47CAMK1G1.08521810
48IRAK31.01002990
49NME21.00848507
50TRIM281.00827482
51PIM10.98891345
52STK100.97880343
53AURKA0.94685414
54IRAK40.94424814
55STK30.92411919
56* CDK20.88817983
57SCYL20.87110086
58CDK80.86671216
59PAK40.86606663
60MELK0.85943352
61CAMK1D0.85015899
62CDK60.80352061
63BMPR1B0.79404385
64TGFBR10.77231056
65MST1R0.76515659
66CDK10.75692379
67FLT30.75307475
68CLK10.73286660
69PBK0.72724805
70MAP3K100.72610294
71MST40.71046286
72NME10.70575602
73TESK20.69885960
74ERBB40.69814703
75RPS6KA50.69039126
76ICK0.66910884
77STK240.62660577
78YES10.61183184
79LATS10.60734992
80BRAF0.58944475
81FGFR10.56908995
82MAP4K10.54588596
83CHUK0.54416761
84CSNK2A10.54003795
85BTK0.53721689
86TEC0.52769873
87KSR10.51757902
88CSNK2A20.51176269
89STK390.50316773
90CDK30.49335475
91BCR0.47242906
92STK38L0.46662331
93NEK90.45684879
94MAPKAPK30.44787596
95MET0.43905932
96CSF1R0.43326423
97PRKDC0.40541283
98LATS20.39031159
99ALK0.38126290
100TNIK0.37771949
101CSNK1G10.37611117
102NEK60.35662716
103GSK3B0.35188884
104JAK30.34947855
105TRPM70.34682737
106IKBKB0.34388917
107PNCK0.33732669
108ERBB30.33638475
109CDK90.33266671
110CSNK1D0.33241307
111MTOR0.33130471
112AKT10.32511673
113NUAK10.31941842
114AKT20.31439973
115CDK180.30759986
116CDK150.30464332
117* MAPK140.30267473
118TXK0.29754743
119CDK11A0.29493571
120PRKCI0.28573694
121PAK10.25043192
122CSNK1E0.22929293
123KIT0.22379331
124LYN0.21942913
125RPS6KB10.21865861
126PKN20.19715918
127ERBB20.18247356

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.33328052
2Mismatch repair_Homo sapiens_hsa034304.63858425
3Homologous recombination_Homo sapiens_hsa034403.52802952
4Base excision repair_Homo sapiens_hsa034103.19980702
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18977701
6Cell cycle_Homo sapiens_hsa041103.11210261
7Spliceosome_Homo sapiens_hsa030403.10070728
8Fanconi anemia pathway_Homo sapiens_hsa034603.06031645
9Nucleotide excision repair_Homo sapiens_hsa034202.87585581
10RNA transport_Homo sapiens_hsa030132.80468057
11One carbon pool by folate_Homo sapiens_hsa006702.73034213
12RNA polymerase_Homo sapiens_hsa030202.54098942
13Non-homologous end-joining_Homo sapiens_hsa034502.46471866
14Ribosome_Homo sapiens_hsa030102.32652704
15* Pyrimidine metabolism_Homo sapiens_hsa002402.26265599
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12596678
17Systemic lupus erythematosus_Homo sapiens_hsa053222.07902818
18Proteasome_Homo sapiens_hsa030502.04458642
19RNA degradation_Homo sapiens_hsa030181.90759881
20p53 signaling pathway_Homo sapiens_hsa041151.76827471
21mRNA surveillance pathway_Homo sapiens_hsa030151.74956397
22Basal transcription factors_Homo sapiens_hsa030221.72931468
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44872317
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32194855
25Viral carcinogenesis_Homo sapiens_hsa052031.24500456
26* Purine metabolism_Homo sapiens_hsa002301.20835407
27Herpes simplex infection_Homo sapiens_hsa051681.17588946
28Epstein-Barr virus infection_Homo sapiens_hsa051691.17341296
29Pyruvate metabolism_Homo sapiens_hsa006201.15604129
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13192870
31Carbon metabolism_Homo sapiens_hsa012001.08539049
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07453216
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00995953
34HTLV-I infection_Homo sapiens_hsa051660.93461612
35MicroRNAs in cancer_Homo sapiens_hsa052060.92211553
36Antigen processing and presentation_Homo sapiens_hsa046120.90955294
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86525330
38Alcoholism_Homo sapiens_hsa050340.85789449
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82628849
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82421973
41Small cell lung cancer_Homo sapiens_hsa052220.80498255
42Oocyte meiosis_Homo sapiens_hsa041140.80484246
43Steroid biosynthesis_Homo sapiens_hsa001000.78700751
44Propanoate metabolism_Homo sapiens_hsa006400.76005090
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74835538
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74708171
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.74539055
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.72806927
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70155336
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70093837
51Primary immunodeficiency_Homo sapiens_hsa053400.68077006
52Measles_Homo sapiens_hsa051620.67539056
53Hepatitis B_Homo sapiens_hsa051610.62428301
54Apoptosis_Homo sapiens_hsa042100.60522531
55Legionellosis_Homo sapiens_hsa051340.58597609
56Chronic myeloid leukemia_Homo sapiens_hsa052200.57633568
57Sulfur relay system_Homo sapiens_hsa041220.56899898
58Colorectal cancer_Homo sapiens_hsa052100.54789517
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54244973
60Notch signaling pathway_Homo sapiens_hsa043300.53528601
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.52713846
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51711634
63Selenocompound metabolism_Homo sapiens_hsa004500.51689293
64N-Glycan biosynthesis_Homo sapiens_hsa005100.51096549
65Wnt signaling pathway_Homo sapiens_hsa043100.50584502
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.50033215
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48485269
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48352132
69Basal cell carcinoma_Homo sapiens_hsa052170.47811278
70Thyroid cancer_Homo sapiens_hsa052160.47540032
71Hedgehog signaling pathway_Homo sapiens_hsa043400.46749225
72TGF-beta signaling pathway_Homo sapiens_hsa043500.46394371
73Folate biosynthesis_Homo sapiens_hsa007900.44646124
74Influenza A_Homo sapiens_hsa051640.43759306
75Pentose phosphate pathway_Homo sapiens_hsa000300.43357636
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41532415
77Hematopoietic cell lineage_Homo sapiens_hsa046400.41267542
78Fatty acid elongation_Homo sapiens_hsa000620.40751050
79Vitamin B6 metabolism_Homo sapiens_hsa007500.39680469
80Shigellosis_Homo sapiens_hsa051310.38160576
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37584173
82Lysine degradation_Homo sapiens_hsa003100.37204381
83Hippo signaling pathway_Homo sapiens_hsa043900.36950109
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36837013
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35623299
86Pathways in cancer_Homo sapiens_hsa052000.35242121
87Prostate cancer_Homo sapiens_hsa052150.35186050
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34405218
89Viral myocarditis_Homo sapiens_hsa054160.33881571
90Pancreatic cancer_Homo sapiens_hsa052120.33448604
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.33008900
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32733072
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32623250
94Leishmaniasis_Homo sapiens_hsa051400.31517110
95Fatty acid metabolism_Homo sapiens_hsa012120.30021072
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29514248
97Arginine biosynthesis_Homo sapiens_hsa002200.28702848
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28452423
99Huntingtons disease_Homo sapiens_hsa050160.27623033
100Adherens junction_Homo sapiens_hsa045200.27368008
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26662694
102Glutathione metabolism_Homo sapiens_hsa004800.26596616
103Tight junction_Homo sapiens_hsa045300.26111217
104Endometrial cancer_Homo sapiens_hsa052130.26068425
105Glioma_Homo sapiens_hsa052140.25382754
106Allograft rejection_Homo sapiens_hsa053300.24380526
107Asthma_Homo sapiens_hsa053100.24346186
108Non-small cell lung cancer_Homo sapiens_hsa052230.24188034
109Bladder cancer_Homo sapiens_hsa052190.24082922
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.22872731
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22749715
112Protein export_Homo sapiens_hsa030600.22544476
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22477458
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21661035
115Proteoglycans in cancer_Homo sapiens_hsa052050.20789089
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20741018
117Biosynthesis of amino acids_Homo sapiens_hsa012300.20707872
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.20428623
119Renin-angiotensin system_Homo sapiens_hsa046140.20275891
120* Metabolic pathways_Homo sapiens_hsa011000.20088802
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20063786
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19922291
123Fructose and mannose metabolism_Homo sapiens_hsa000510.19586248
124HIF-1 signaling pathway_Homo sapiens_hsa040660.19572695
125Autoimmune thyroid disease_Homo sapiens_hsa053200.19422349
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18797306
127Melanoma_Homo sapiens_hsa052180.18364894
128FoxO signaling pathway_Homo sapiens_hsa040680.18331467
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18070935
130Acute myeloid leukemia_Homo sapiens_hsa052210.17767558
131AMPK signaling pathway_Homo sapiens_hsa041520.17016236
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16988954
133Graft-versus-host disease_Homo sapiens_hsa053320.15825266
134B cell receptor signaling pathway_Homo sapiens_hsa046620.15820979
135Arginine and proline metabolism_Homo sapiens_hsa003300.15198122
136TNF signaling pathway_Homo sapiens_hsa046680.14158200

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