POLB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.07374012
2regulation of meiosis I (GO:0060631)4.82493056
3behavioral response to nicotine (GO:0035095)4.61812193
4long-chain fatty acid biosynthetic process (GO:0042759)4.43865281
5startle response (GO:0001964)4.25007128
6pyrimidine nucleobase catabolic process (GO:0006208)4.11845174
7presynaptic membrane organization (GO:0097090)4.08803734
8presynaptic membrane assembly (GO:0097105)3.96051734
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.94522054
10DNA methylation involved in gamete generation (GO:0043046)3.86356461
11protein neddylation (GO:0045116)3.85088527
12neuron cell-cell adhesion (GO:0007158)3.79117253
13centriole replication (GO:0007099)3.77702630
14protein polyglutamylation (GO:0018095)3.68562231
15protein complex biogenesis (GO:0070271)3.68533847
16chaperone-mediated protein transport (GO:0072321)3.59394093
17retinal cone cell development (GO:0046549)3.56568506
18male meiosis I (GO:0007141)3.54325368
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50764066
20ATP synthesis coupled proton transport (GO:0015986)3.50764066
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48411285
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.47973308
23NADH dehydrogenase complex assembly (GO:0010257)3.47973308
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47973308
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43221613
26auditory behavior (GO:0031223)3.35169787
27mechanosensory behavior (GO:0007638)3.33270074
28neural tube formation (GO:0001841)3.28810611
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24253075
30nucleobase catabolic process (GO:0046113)3.21641505
31response to pheromone (GO:0019236)3.20076006
32synapsis (GO:0007129)3.18122721
33mitochondrial respiratory chain complex assembly (GO:0033108)3.17647531
34gamma-aminobutyric acid transport (GO:0015812)3.17123501
35seminiferous tubule development (GO:0072520)3.15636742
36protein localization to cilium (GO:0061512)3.14291958
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11863225
38resolution of meiotic recombination intermediates (GO:0000712)3.11713133
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.09500800
40intraciliary transport (GO:0042073)3.09438076
41meiotic cell cycle (GO:0051321)3.07892839
42replication fork processing (GO:0031297)3.06337060
43positive regulation of mitochondrial fission (GO:0090141)3.03260318
44negative regulation of DNA-dependent DNA replication (GO:2000104)3.00801770
45acrosome reaction (GO:0007340)3.00714953
46cullin deneddylation (GO:0010388)2.99276232
47epithelial cilium movement (GO:0003351)2.98833267
48gamma-aminobutyric acid signaling pathway (GO:0007214)2.98709401
49protein localization to synapse (GO:0035418)2.97521135
50somite rostral/caudal axis specification (GO:0032525)2.92160073
51glutamate receptor signaling pathway (GO:0007215)2.89834193
52meiosis I (GO:0007127)2.88673569
53respiratory electron transport chain (GO:0022904)2.87748230
54chromatin remodeling at centromere (GO:0031055)2.87350497
55male meiosis (GO:0007140)2.86862469
56positive regulation of gastrulation (GO:2000543)2.85123033
57regulation of mitotic spindle checkpoint (GO:1903504)2.84777015
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84777015
59proteasome assembly (GO:0043248)2.83262826
60regulation of cilium movement (GO:0003352)2.82534482
61electron transport chain (GO:0022900)2.81168369
62RNA capping (GO:0036260)2.80732654
637-methylguanosine RNA capping (GO:0009452)2.80732654
64central nervous system myelination (GO:0022010)2.80480806
65axon ensheathment in central nervous system (GO:0032291)2.80480806
66neuron-neuron synaptic transmission (GO:0007270)2.77533176
67detection of light stimulus involved in visual perception (GO:0050908)2.77048506
68detection of light stimulus involved in sensory perception (GO:0050962)2.77048506
69ionotropic glutamate receptor signaling pathway (GO:0035235)2.76370654
70positive regulation of synapse assembly (GO:0051965)2.76317556
71regulation of DNA methylation (GO:0044030)2.75990981
72synaptic transmission, glutamatergic (GO:0035249)2.75527327
73regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.75257904
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74921943
75multicellular organism reproduction (GO:0032504)2.74651230
76synaptic vesicle exocytosis (GO:0016079)2.73638769
777-methylguanosine mRNA capping (GO:0006370)2.72473085
78regulation of nuclear cell cycle DNA replication (GO:0033262)2.71603887
79transferrin transport (GO:0033572)2.71476487
80negative regulation of neurotransmitter transport (GO:0051589)2.69952006
81CENP-A containing nucleosome assembly (GO:0034080)2.69255151
82protein deneddylation (GO:0000338)2.68165671
83DNA double-strand break processing (GO:0000729)2.67263713
84neurofilament cytoskeleton organization (GO:0060052)2.64869833
85positive regulation of meiosis (GO:0045836)2.64474406
86transmission of nerve impulse (GO:0019226)2.64021090
87sperm motility (GO:0030317)2.63697156
88histone exchange (GO:0043486)2.63422746
89postsynaptic membrane organization (GO:0001941)2.61472582
90single strand break repair (GO:0000012)2.60646496
91response to redox state (GO:0051775)2.59586333
92microtubule polymerization or depolymerization (GO:0031109)2.59071772
93mannosylation (GO:0097502)2.58915761
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57945582
95vocalization behavior (GO:0071625)2.57861313
96negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57798040
97response to auditory stimulus (GO:0010996)2.57687953
98protein-cofactor linkage (GO:0018065)2.57412116
99cytochrome complex assembly (GO:0017004)2.56733573
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56033644
101regulation of female gonad development (GO:2000194)2.55942993
102centriole assembly (GO:0098534)2.55478275
103positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.55267218
104somite development (GO:0061053)2.54668480
105serotonin receptor signaling pathway (GO:0007210)2.53871443
106positive regulation of action potential (GO:0045760)2.53508410
107phagosome maturation (GO:0090382)2.52633022
108cilium movement (GO:0003341)2.51909085
109positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.51476168
110regulation of glutamate secretion (GO:0014048)2.50917259
111cilium assembly (GO:0042384)2.50801639
112viral protein processing (GO:0019082)2.50327798
113axoneme assembly (GO:0035082)2.48567206
114positive regulation of meiotic cell cycle (GO:0051446)2.47948036
115sympathetic nervous system development (GO:0048485)2.47477801
116limb bud formation (GO:0060174)2.46758398
117axonemal dynein complex assembly (GO:0070286)2.46351819
118regulation of timing of cell differentiation (GO:0048505)2.45608105
119protein K11-linked deubiquitination (GO:0035871)2.45372339
120negative regulation of appetite (GO:0032099)2.45054441
121negative regulation of response to food (GO:0032096)2.45054441
122GTP biosynthetic process (GO:0006183)2.44823155
123trivalent inorganic cation transport (GO:0072512)2.44586608
124ferric iron transport (GO:0015682)2.44586608
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.44089841
126reciprocal meiotic recombination (GO:0007131)2.43708016
127reciprocal DNA recombination (GO:0035825)2.43708016
128nonmotile primary cilium assembly (GO:0035058)2.43687850
129sperm-egg recognition (GO:0035036)2.43312691
130neuron recognition (GO:0008038)2.43280199
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.42901157
132gene silencing by RNA (GO:0031047)2.42435538
133cilium or flagellum-dependent cell motility (GO:0001539)2.42318504
134rhodopsin mediated signaling pathway (GO:0016056)2.42255924
135ubiquinone biosynthetic process (GO:0006744)2.42045565
136hydrogen ion transmembrane transport (GO:1902600)2.41207619
137glycerophospholipid catabolic process (GO:0046475)2.40690679
138ATP hydrolysis coupled proton transport (GO:0015991)2.40124112
139energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.40124112
140ubiquinone metabolic process (GO:0006743)2.39992903
141calcium ion-dependent exocytosis (GO:0017156)2.39839249
142RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.39794539
143tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.39794539
144negative regulation of telomere maintenance (GO:0032205)2.38609092
145regulation of development, heterochronic (GO:0040034)2.38004007
146cilium organization (GO:0044782)2.37750813
147spinal cord motor neuron differentiation (GO:0021522)2.37541379
148righting reflex (GO:0060013)2.37196076
149microtubule depolymerization (GO:0007019)2.37141885
150GPI anchor biosynthetic process (GO:0006506)2.37091520
151dopamine transport (GO:0015872)2.37025592
152DNA damage response, detection of DNA damage (GO:0042769)2.36498316
153organelle disassembly (GO:1903008)2.36172561
154somatic hypermutation of immunoglobulin genes (GO:0016446)2.36034744
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35368998
156neuronal action potential propagation (GO:0019227)2.34990363
157cochlea development (GO:0090102)2.33440677
158respiratory chain complex IV assembly (GO:0008535)2.33131674
159guanosine-containing compound biosynthetic process (GO:1901070)2.32656916
160innervation (GO:0060384)2.32536188
161regulation of synaptic transmission, GABAergic (GO:0032228)2.31391888
162urinary tract smooth muscle contraction (GO:0014848)2.31311488
163synaptic vesicle endocytosis (GO:0048488)2.31118431
164fatty acid elongation (GO:0030497)2.29760943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.94780951
2GBX2_23144817_ChIP-Seq_PC3_Human3.74235735
3ZNF274_21170338_ChIP-Seq_K562_Hela3.49462738
4* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.27790917
5ZFP57_27257070_Chip-Seq_ESCs_Mouse3.01584286
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95638064
7TAF15_26573619_Chip-Seq_HEK293_Human2.60490813
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.42461662
9VDR_22108803_ChIP-Seq_LS180_Human2.40336412
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35918437
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.33909716
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30055106
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26167237
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21368825
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12660017
16FUS_26573619_Chip-Seq_HEK293_Human2.08409928
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05071396
18P300_19829295_ChIP-Seq_ESCs_Human1.99034768
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.98575839
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94614128
21RNF2_27304074_Chip-Seq_NSC_Mouse1.91842899
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90866463
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90220248
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.89396610
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.87845730
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.85957545
27IRF1_19129219_ChIP-ChIP_H3396_Human1.75068667
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74489312
29ER_23166858_ChIP-Seq_MCF-7_Human1.74003362
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71289389
31REST_21632747_ChIP-Seq_MESCs_Mouse1.65400028
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64946394
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62992746
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59864500
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.59219189
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58284904
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57192545
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57140819
39SMAD4_21799915_ChIP-Seq_A2780_Human1.55372523
40EWS_26573619_Chip-Seq_HEK293_Human1.55101776
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54922123
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54737866
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.54621332
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51044898
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.49825347
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48723655
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48501728
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47475080
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47066198
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46993053
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46826674
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45094571
53TP53_22573176_ChIP-Seq_HFKS_Human1.42346963
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.41884887
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41851426
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41799221
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.41761029
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41578385
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41528385
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41289774
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.39528119
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39401511
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39204993
64P53_22387025_ChIP-Seq_ESCs_Mouse1.38829935
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.37829524
66EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37630114
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.37449808
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35098506
69STAT3_18555785_Chip-Seq_ESCs_Mouse1.35016444
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.34090490
71IGF1R_20145208_ChIP-Seq_DFB_Human1.33735188
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33605602
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31933141
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31933141
75MYC_18940864_ChIP-ChIP_HL60_Human1.31537208
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.31519703
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30959886
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30959886
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30794353
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30277965
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29915064
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27803238
83P300_18555785_Chip-Seq_ESCs_Mouse1.26979528
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.25555714
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25453281
86AR_25329375_ChIP-Seq_VCAP_Human1.24398674
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.23726727
88VDR_23849224_ChIP-Seq_CD4+_Human1.23584252
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22813463
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.22534568
91ELK1_19687146_ChIP-ChIP_HELA_Human1.22330157
92BCAT_22108803_ChIP-Seq_LS180_Human1.21512746
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21487573
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.21162474
95NANOG_19829295_ChIP-Seq_ESCs_Human1.20113151
96SOX2_19829295_ChIP-Seq_ESCs_Human1.20113151
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18876732
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18409103
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17966206
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17460243
101RUNX2_22187159_ChIP-Seq_PCA_Human1.17230203
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.17068713
103RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17058880
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16122376
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15602631
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.14956008
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.14401068
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14165742
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13532532
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13173617
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.12740748
112KLF4_18555785_Chip-Seq_ESCs_Mouse1.12508673
113* PRDM14_20953172_ChIP-Seq_ESCs_Human1.11302201
114REST_18959480_ChIP-ChIP_MESCs_Mouse1.10853392
115SOX9_26525672_Chip-Seq_HEART_Mouse1.10378175
116KDM2B_26808549_Chip-Seq_REH_Human1.10285058
117JUN_21703547_ChIP-Seq_K562_Human1.09712786
118AR_21572438_ChIP-Seq_LNCaP_Human1.09678862
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09024176
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06382188
121ZFX_18555785_Chip-Seq_ESCs_Mouse1.06158077
122* TCF4_23295773_ChIP-Seq_U87_Human1.04818878
123STAT3_23295773_ChIP-Seq_U87_Human1.04694274
124CBP_20019798_ChIP-Seq_JUKART_Human1.04196129
125TCF4_22108803_ChIP-Seq_LS180_Human1.03082574
126FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02890906
127FOXA1_25329375_ChIP-Seq_VCAP_Human1.02890906
128NCOR_22424771_ChIP-Seq_293T_Human0.99473145
129ETS1_20019798_ChIP-Seq_JURKAT_Human0.99468953
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99383603
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96657214
132HTT_18923047_ChIP-ChIP_STHdh_Human0.93632250
133FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93301211
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92815495
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92270301
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91555559
137E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89751193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.39771464
2MP0002736_abnormal_nociception_after2.90046837
3MP0001529_abnormal_vocalization2.75136619
4MP0001984_abnormal_olfaction2.59236021
5MP0001968_abnormal_touch/_nociception2.58408120
6MP0005423_abnormal_somatic_nervous2.51325190
7MP0001905_abnormal_dopamine_level2.48802976
8MP0001188_hyperpigmentation2.46728641
9MP0004859_abnormal_synaptic_plasticity2.39754313
10MP0005410_abnormal_fertilization2.34471782
11MP0003890_abnormal_embryonic-extraembry2.22363505
12MP0009745_abnormal_behavioral_response2.18769340
13MP0003635_abnormal_synaptic_transmissio2.17039892
14MP0000778_abnormal_nervous_system2.16091581
15MP0006292_abnormal_olfactory_placode2.16022567
16MP0008058_abnormal_DNA_repair2.13729295
17MP0001346_abnormal_lacrimal_gland2.13709367
18MP0003136_yellow_coat_color2.10109726
19MP0003787_abnormal_imprinting2.06311808
20MP0002272_abnormal_nervous_system2.06054968
21MP0002163_abnormal_gland_morphology2.05053333
22MP0005646_abnormal_pituitary_gland2.04429086
23MP0002063_abnormal_learning/memory/cond2.04210115
24MP0009046_muscle_twitch2.03320615
25MP0001486_abnormal_startle_reflex2.02198729
26MP0006276_abnormal_autonomic_nervous1.98629090
27MP0002734_abnormal_mechanical_nocicepti1.98227737
28MP0002064_seizures1.97994145
29MP0002572_abnormal_emotion/affect_behav1.97683038
30MP0005551_abnormal_eye_electrophysiolog1.96698117
31MP0005171_absent_coat_pigmentation1.89987330
32MP0002822_catalepsy1.88933569
33MP0002735_abnormal_chemical_nociception1.88505169
34MP0004270_analgesia1.79604586
35MP0010386_abnormal_urinary_bladder1.76902894
36MP0002102_abnormal_ear_morphology1.75802986
37MP0002184_abnormal_innervation1.71774527
38MP0001502_abnormal_circadian_rhythm1.70558960
39MP0008877_abnormal_DNA_methylation1.68678058
40MP0001986_abnormal_taste_sensitivity1.67966048
41MP0004142_abnormal_muscle_tone1.66283703
42MP0004742_abnormal_vestibular_system1.62990791
43* MP0002067_abnormal_sensory_capabilities1.61104584
44MP0000569_abnormal_digit_pigmentation1.59234233
45MP0002876_abnormal_thyroid_physiology1.54912636
46MP0002210_abnormal_sex_determination1.50962696
47MP0002234_abnormal_pharynx_morphology1.50474335
48MP0005409_darkened_coat_color1.49615910
49MP0005386_behavior/neurological_phenoty1.43277986
50MP0004924_abnormal_behavior1.43277986
51MP0008995_early_reproductive_senescence1.39027030
52MP0001440_abnormal_grooming_behavior1.38919533
53MP0002638_abnormal_pupillary_reflex1.37653711
54MP0001970_abnormal_pain_threshold1.36695492
55MP0008789_abnormal_olfactory_epithelium1.28705702
56MP0000026_abnormal_inner_ear1.28310546
57MP0001501_abnormal_sleep_pattern1.26689053
58MP0005379_endocrine/exocrine_gland_phen1.25783256
59MP0000566_synostosis1.25222695
60MP0000920_abnormal_myelination1.24115938
61MP0001293_anophthalmia1.23624291
62MP0002557_abnormal_social/conspecific_i1.19887677
63MP0004133_heterotaxia1.19446072
64MP0002752_abnormal_somatic_nervous1.19239578
65MP0000653_abnormal_sex_gland1.18947277
66MP0003698_abnormal_male_reproductive1.18663952
67MP0006072_abnormal_retinal_apoptosis1.18513089
68MP0002277_abnormal_respiratory_mucosa1.18368080
69MP0002160_abnormal_reproductive_system1.17619336
70MP0001963_abnormal_hearing_physiology1.17357565
71MP0002837_dystrophic_cardiac_calcinosis1.16697861
72* MP0002882_abnormal_neuron_morphology1.15786595
73MP0005394_taste/olfaction_phenotype1.14448940
74MP0005499_abnormal_olfactory_system1.14448940
75MP0001145_abnormal_male_reproductive1.14297467
76MP0003646_muscle_fatigue1.13873568
77MP0000049_abnormal_middle_ear1.13855225
78MP0005645_abnormal_hypothalamus_physiol1.12565349
79MP0000015_abnormal_ear_pigmentation1.12553609
80MP0005253_abnormal_eye_physiology1.12148942
81MP0006035_abnormal_mitochondrial_morpho1.10825880
82MP0008872_abnormal_physiological_respon1.08782037
83MP0003119_abnormal_digestive_system1.08654404
84MP0000955_abnormal_spinal_cord1.07506257
85MP0002733_abnormal_thermal_nociception1.07347581
86MP0003195_calcinosis1.07046534
87MP0005248_abnormal_Harderian_gland1.06452570
88MP0003121_genomic_imprinting1.04541961
89MP0000427_abnormal_hair_cycle1.04124045
90MP0000631_abnormal_neuroendocrine_gland1.02241571
91MP0003693_abnormal_embryo_hatching1.02156281
92MP0002653_abnormal_ependyma_morphology1.01889019
93MP0002229_neurodegeneration1.01554085
94MP0004885_abnormal_endolymph1.00849163
95MP0002751_abnormal_autonomic_nervous1.00090964
96MP0008569_lethality_at_weaning0.97447117
97MP0003122_maternal_imprinting0.97203131
98MP0002928_abnormal_bile_duct0.94871681
99MP0004215_abnormal_myocardial_fiber0.93736695
100* MP0002066_abnormal_motor_capabilities/c0.93097252
101MP0008260_abnormal_autophagy0.90971638
102MP0002161_abnormal_fertility/fecundity0.90642596
103MP0003938_abnormal_ear_development0.89773598
104MP0004381_abnormal_hair_follicle0.89540516
105MP0009379_abnormal_foot_pigmentation0.88800974
106MP0003011_delayed_dark_adaptation0.88075799
107MP0003567_abnormal_fetal_cardiomyocyte0.87074628
108MP0009697_abnormal_copulation0.86234521
109MP0005389_reproductive_system_phenotype0.86090591
110MP0008057_abnormal_DNA_replication0.84876916
111MP0003632_abnormal_nervous_system0.83146372
112MP0002938_white_spotting0.83020808
113MP0005084_abnormal_gallbladder_morpholo0.82389413
114MP0005195_abnormal_posterior_eye0.82348454
115MP0001485_abnormal_pinna_reflex0.79637538
116MP0000372_irregular_coat_pigmentation0.78543737
117MP0005395_other_phenotype0.77421492
118MP0001929_abnormal_gametogenesis0.77007238
119* MP0004811_abnormal_neuron_physiology0.76204674
120MP0006036_abnormal_mitochondrial_physio0.75412468
121MP0002233_abnormal_nose_morphology0.74878288
122MP0002148_abnormal_hypersensitivity_rea0.74287711
123MP0004782_abnormal_surfactant_physiolog0.74043917
124MP0001835_abnormal_antigen_presentation0.73717542
125MP0004145_abnormal_muscle_electrophysio0.73541494
126* MP0002152_abnormal_brain_morphology0.73177321
127MP0004147_increased_porphyrin_level0.72594613
128MP0003631_nervous_system_phenotype0.69421767
129MP0002090_abnormal_vision0.67837357
130MP0005451_abnormal_body_composition0.65624071
131MP0003718_maternal_effect0.63871265
132MP0004134_abnormal_chest_morphology0.63869593

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.11891138
2Abnormal hair whorl (HP:0010721)4.02696871
3Absent/shortened dynein arms (HP:0200106)3.87437196
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.87437196
5Abnormal mitochondria in muscle tissue (HP:0008316)3.55963206
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.55446854
7Progressive macrocephaly (HP:0004481)3.49068616
8Medial flaring of the eyebrow (HP:0010747)3.47598294
9Parakeratosis (HP:0001036)3.24941043
10Mitochondrial inheritance (HP:0001427)3.22464668
11Focal motor seizures (HP:0011153)3.20545020
12Optic disc pallor (HP:0000543)3.06605729
13Abnormality of the labia minora (HP:0012880)3.00957717
14Gait imbalance (HP:0002141)2.98391795
15Febrile seizures (HP:0002373)2.96893817
16True hermaphroditism (HP:0010459)2.94141395
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.93571637
18Epileptic encephalopathy (HP:0200134)2.92834024
19Acute encephalopathy (HP:0006846)2.86405723
20Abnormal ciliary motility (HP:0012262)2.83159200
21Pancreatic fibrosis (HP:0100732)2.81271238
22Abnormal respiratory motile cilium physiology (HP:0012261)2.81122113
23Atonic seizures (HP:0010819)2.80069031
24Congenital primary aphakia (HP:0007707)2.79026683
25Abnormal respiratory motile cilium morphology (HP:0005938)2.76827887
26Abnormal respiratory epithelium morphology (HP:0012253)2.76827887
27Nephronophthisis (HP:0000090)2.72424765
28Nephrogenic diabetes insipidus (HP:0009806)2.72027145
293-Methylglutaconic aciduria (HP:0003535)2.71898104
30Congenital stationary night blindness (HP:0007642)2.64239192
31Type II lissencephaly (HP:0007260)2.61276685
32Oligodactyly (hands) (HP:0001180)2.61103977
33Increased CSF lactate (HP:0002490)2.59711754
34Genital tract atresia (HP:0001827)2.52568941
35Septo-optic dysplasia (HP:0100842)2.50036144
36Abnormality of the renal cortex (HP:0011035)2.49617810
37Molar tooth sign on MRI (HP:0002419)2.48255959
38Abnormality of midbrain morphology (HP:0002418)2.48255959
39Vaginal atresia (HP:0000148)2.47843488
40Hypothermia (HP:0002045)2.43910107
41Hyperventilation (HP:0002883)2.42715476
42Myokymia (HP:0002411)2.42147826
43Volvulus (HP:0002580)2.41066721
44Progressive cerebellar ataxia (HP:0002073)2.39169123
45Pancreatic cysts (HP:0001737)2.39092245
46Poor coordination (HP:0002370)2.33768922
47Leukodystrophy (HP:0002415)2.32777644
48Pendular nystagmus (HP:0012043)2.31762531
49Supernumerary spleens (HP:0009799)2.29915502
50Pheochromocytoma (HP:0002666)2.27726940
51Decreased central vision (HP:0007663)2.27367656
52Colon cancer (HP:0003003)2.22151874
53Neuroendocrine neoplasm (HP:0100634)2.22076593
54Retinal dysplasia (HP:0007973)2.21045225
55Optic nerve hypoplasia (HP:0000609)2.18677377
56Renal Fanconi syndrome (HP:0001994)2.17344977
57Renal cortical cysts (HP:0000803)2.16446260
58Increased serum pyruvate (HP:0003542)2.15239876
59Abnormality of glycolysis (HP:0004366)2.15239876
60Anencephaly (HP:0002323)2.09955149
61Patchy hypopigmentation of hair (HP:0011365)2.09095121
62Abnormality of the renal medulla (HP:0100957)2.08107396
63Abnormality of macular pigmentation (HP:0008002)2.05618123
64Hyperglycinemia (HP:0002154)2.04986184
65Hepatocellular necrosis (HP:0001404)2.02593547
66White forelock (HP:0002211)2.00647600
67Abnormality of the septum pellucidum (HP:0007375)1.99394822
68Attenuation of retinal blood vessels (HP:0007843)1.98904902
69Increased hepatocellular lipid droplets (HP:0006565)1.97878202
70Preaxial hand polydactyly (HP:0001177)1.97674330
71Broad-based gait (HP:0002136)1.96525423
72Methylmalonic acidemia (HP:0002912)1.95256659
73Retrobulbar optic neuritis (HP:0100654)1.94437689
74Optic neuritis (HP:0100653)1.94437689
75Abnormality of incisor morphology (HP:0011063)1.93549277
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.92373176
77Pachygyria (HP:0001302)1.91610837
78Limb dystonia (HP:0002451)1.91157355
79Severe visual impairment (HP:0001141)1.90972765
80Sclerocornea (HP:0000647)1.90854291
81Fetal akinesia sequence (HP:0001989)1.88525170
82Focal seizures (HP:0007359)1.85975597
83Abnormality of renal resorption (HP:0011038)1.85912908
84Lipid accumulation in hepatocytes (HP:0006561)1.85887865
85Aplasia/Hypoplasia of the lens (HP:0008063)1.85278341
86Tubulointerstitial nephritis (HP:0001970)1.84644760
87Thyroid-stimulating hormone excess (HP:0002925)1.84398144
88Bile duct proliferation (HP:0001408)1.83898566
89Abnormal biliary tract physiology (HP:0012439)1.83898566
90Bony spicule pigmentary retinopathy (HP:0007737)1.83836141
91Cystic liver disease (HP:0006706)1.83726240
92Gaze-evoked nystagmus (HP:0000640)1.82981864
93Drooling (HP:0002307)1.82840420
94Absent septum pellucidum (HP:0001331)1.82827052
95Abolished electroretinogram (ERG) (HP:0000550)1.81725880
96Abnormality of the corticospinal tract (HP:0002492)1.81563099
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.81293365
98Severe Myopia (HP:0011003)1.80993979
99Congenital ichthyosiform erythroderma (HP:0007431)1.80449191
100Cerebellar dysplasia (HP:0007033)1.80243578
101Dialeptic seizures (HP:0011146)1.79727941
102Genetic anticipation (HP:0003743)1.78809565
103Chorioretinal coloboma (HP:0000567)1.78093059
104Duplicated collecting system (HP:0000081)1.78010809
105Polyphagia (HP:0002591)1.77329541
106Exercise intolerance (HP:0003546)1.77221939
107Postaxial foot polydactyly (HP:0001830)1.76581198
108Rhinitis (HP:0012384)1.76392341
109Central scotoma (HP:0000603)1.75270870
110Dyskinesia (HP:0100660)1.74675768
111Specific learning disability (HP:0001328)1.74012622
112Male pseudohermaphroditism (HP:0000037)1.73762280
113Type 2 muscle fiber atrophy (HP:0003554)1.73431283
114Patellar aplasia (HP:0006443)1.73366884
115Absence seizures (HP:0002121)1.72902508
116Increased IgM level (HP:0003496)1.71656666
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71513907
118Abnormality of alanine metabolism (HP:0010916)1.71513907
119Hyperalaninemia (HP:0003348)1.71513907
120Progressive inability to walk (HP:0002505)1.71008517
121Abnormal rod and cone electroretinograms (HP:0008323)1.70840930
122Narrow forehead (HP:0000341)1.70595291
123Inability to walk (HP:0002540)1.69674630
124Tubular atrophy (HP:0000092)1.68817804
125Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68658112
126Small hand (HP:0200055)1.68282371
127Abnormality of the renal collecting system (HP:0004742)1.67656147
128Abnormality of the ileum (HP:0001549)1.66415919
129Aplasia/Hypoplasia of the patella (HP:0006498)1.66248572
130Sensory axonal neuropathy (HP:0003390)1.64663219
131Aganglionic megacolon (HP:0002251)1.64234442
132Esotropia (HP:0000565)1.62661831
133Adrenal hypoplasia (HP:0000835)1.62188571
134Postaxial hand polydactyly (HP:0001162)1.61370877
135Occipital encephalocele (HP:0002085)1.61302281
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.60769533
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.60769533
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60657141
139Short tibia (HP:0005736)1.59802219
140Chronic hepatic failure (HP:0100626)1.59118196
141Lissencephaly (HP:0001339)1.58537968
142Protruding tongue (HP:0010808)1.57574682
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.56542740
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.55730072
145Gastroesophageal reflux (HP:0002020)1.54920337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.88292311
2PRPF4B3.86281055
3MAP2K72.80559762
4TNIK2.51449014
5BCR2.49883106
6NUAK12.42892311
7BMPR1B2.42385603
8TRIM282.38171357
9FRK2.27069020
10MAP4K22.26760822
11MARK12.19705357
12MAP3K122.17150187
13NME12.12060696
14MAPK131.92436321
15STK161.86633204
16TAOK31.80722012
17BMPR21.79081650
18OXSR11.65687894
19ACVR1B1.64903330
20PLK21.64045153
21NTRK31.62723343
22NTRK21.57183534
23MAP3K41.54954545
24EPHA41.52180705
25STK391.48932050
26SRPK11.48141593
27SIK31.47390668
28DYRK21.41912103
29GRK71.41030377
30ADRBK21.35397100
31ERBB31.35267558
32PKN11.33780468
33YES11.30911064
34DYRK31.25970598
35ARAF1.25671166
36CDC71.25576726
37AKT31.20500394
38CSNK1G31.19010185
39PNCK1.13976752
40CDK31.12678896
41PBK1.12051071
42BRAF1.11005388
43STK38L1.10870898
44NEK61.09953070
45TAOK21.07033012
46CDK191.06342291
47GRK51.05544421
48MKNK11.04102971
49CSNK1A1L1.03452679
50OBSCN0.96920910
51MAPKAPK50.95013921
52TLK10.94720602
53PAK30.94077441
54BCKDK0.93638318
55TXK0.93081932
56SGK4940.92915008
57SGK2230.92915008
58CAMK2A0.89990653
59DYRK1A0.89656877
60PLK40.89210305
61ZAK0.88798128
62MAP3K140.87614528
63PLK10.85210970
64MINK10.85026365
65CAMK2B0.84024273
66MAP3K90.83739736
67CDK80.82822352
68TTK0.82458395
69PRKCE0.82135395
70CSNK1G20.80668181
71PDK30.80108417
72PDK40.80108417
73MKNK20.79620991
74VRK10.78530210
75MYLK0.77290199
76BUB10.75368695
77IRAK40.74759293
78PDK20.71525264
79SGK20.68258506
80EIF2AK20.66766190
81MST40.66492293
82EIF2AK30.66242610
83CSNK1G10.65483257
84UHMK10.64431043
85GRK10.62895667
86INSRR0.62399409
87PLK30.60171824
88WEE10.59823151
89PRKCG0.59711388
90DAPK20.58942173
91CDK50.58801400
92PHKG20.57789400
93PHKG10.57789400
94LIMK10.55453860
95CAMK2D0.55060542
96ATR0.54887256
97FGR0.54691735
98MAP2K40.53912619
99RPS6KA50.53420701
100TSSK60.50921577
101TGFBR10.50752284
102CAMK2G0.50442789
103WNK10.50076857
104PINK10.49865931
105PRKG10.49041153
106CLK10.48485967
107AURKA0.48111854
108STK240.48070886
109WNK40.47121628
110TAF10.47083556
111MUSK0.46861014
112KSR10.46114687
113ADRBK10.45050695
114NEK20.44475340
115CCNB10.43539148
116CHEK20.43382141
117TIE10.43049906
118TNK20.42993648
119CSNK1E0.42802816
120PRKACA0.42782688
121DYRK1B0.42649138
122PRKCZ0.42511936
123ROCK20.41454925
124LATS10.40983086
125CAMK10.40525212
126RIPK40.39772759
127ATM0.38044283
128WNK30.37512838
129PRKCI0.37443819
130IRAK10.37119074
131STK30.36734575
132SIK20.36552124
133CDK180.36481835
134PRKACB0.36434060
135STK110.36204301
136IKBKB0.35964284
137MAP2K60.35844861
138PIM20.35552518

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.92033648
2Nicotine addiction_Homo sapiens_hsa050333.17796792
3Parkinsons disease_Homo sapiens_hsa050123.15379045
4Proteasome_Homo sapiens_hsa030502.79036748
5Collecting duct acid secretion_Homo sapiens_hsa049662.70458702
6Alzheimers disease_Homo sapiens_hsa050102.57455993
7Huntingtons disease_Homo sapiens_hsa050162.39051705
8Synaptic vesicle cycle_Homo sapiens_hsa047212.21060457
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18213489
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04835564
11Homologous recombination_Homo sapiens_hsa034401.98351934
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95138915
13Phototransduction_Homo sapiens_hsa047441.94868246
14Serotonergic synapse_Homo sapiens_hsa047261.80681379
15Mismatch repair_Homo sapiens_hsa034301.79317918
16RNA polymerase_Homo sapiens_hsa030201.78652582
17Allograft rejection_Homo sapiens_hsa053301.75608928
18Butanoate metabolism_Homo sapiens_hsa006501.72402937
19Rheumatoid arthritis_Homo sapiens_hsa053231.71393106
20Cardiac muscle contraction_Homo sapiens_hsa042601.70682364
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67218650
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67218254
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66984872
24Ether lipid metabolism_Homo sapiens_hsa005651.66154628
25GABAergic synapse_Homo sapiens_hsa047271.65120994
26Morphine addiction_Homo sapiens_hsa050321.62457762
27Protein export_Homo sapiens_hsa030601.59951094
28Propanoate metabolism_Homo sapiens_hsa006401.57733403
29Glutamatergic synapse_Homo sapiens_hsa047241.57730166
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.55561449
31Autoimmune thyroid disease_Homo sapiens_hsa053201.55148107
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53772199
33Selenocompound metabolism_Homo sapiens_hsa004501.52701609
34Circadian entrainment_Homo sapiens_hsa047131.51126386
35Vibrio cholerae infection_Homo sapiens_hsa051101.49884629
36Basal transcription factors_Homo sapiens_hsa030221.48891409
37Graft-versus-host disease_Homo sapiens_hsa053321.45337781
38Taste transduction_Homo sapiens_hsa047421.45227265
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39722313
40RNA transport_Homo sapiens_hsa030131.35901442
41Type I diabetes mellitus_Homo sapiens_hsa049401.31916027
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30002284
43Caffeine metabolism_Homo sapiens_hsa002321.25419118
44Olfactory transduction_Homo sapiens_hsa047401.23829269
45Oocyte meiosis_Homo sapiens_hsa041141.23126659
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18801359
47Non-homologous end-joining_Homo sapiens_hsa034501.16929727
48Dopaminergic synapse_Homo sapiens_hsa047281.10156043
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04032346
50Sphingolipid metabolism_Homo sapiens_hsa006001.02691393
51Amphetamine addiction_Homo sapiens_hsa050311.01815266
52Axon guidance_Homo sapiens_hsa043600.98964428
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98557892
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97821229
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97758792
56Fatty acid elongation_Homo sapiens_hsa000620.97338826
57Cell cycle_Homo sapiens_hsa041100.96825253
58Peroxisome_Homo sapiens_hsa041460.94668211
59Linoleic acid metabolism_Homo sapiens_hsa005910.94278957
60Phagosome_Homo sapiens_hsa041450.93974025
61Long-term depression_Homo sapiens_hsa047300.93796955
62Arachidonic acid metabolism_Homo sapiens_hsa005900.91857443
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91097445
64Tryptophan metabolism_Homo sapiens_hsa003800.90820503
65Calcium signaling pathway_Homo sapiens_hsa040200.87942094
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.84334346
67Fanconi anemia pathway_Homo sapiens_hsa034600.83858208
68Renin secretion_Homo sapiens_hsa049240.83081383
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.82928963
70Long-term potentiation_Homo sapiens_hsa047200.82832439
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.80952431
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80049488
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.79138772
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79023056
75Steroid biosynthesis_Homo sapiens_hsa001000.77532311
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77162342
77DNA replication_Homo sapiens_hsa030300.77033732
78Vitamin B6 metabolism_Homo sapiens_hsa007500.76928160
79Cholinergic synapse_Homo sapiens_hsa047250.75117472
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73675814
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73118711
82Purine metabolism_Homo sapiens_hsa002300.72858261
83Asthma_Homo sapiens_hsa053100.72563571
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71957591
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71429238
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70093442
87* Base excision repair_Homo sapiens_hsa034100.69726037
88Cocaine addiction_Homo sapiens_hsa050300.69660378
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69258251
90Nitrogen metabolism_Homo sapiens_hsa009100.66621535
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63188666
92RNA degradation_Homo sapiens_hsa030180.60769611
93Retinol metabolism_Homo sapiens_hsa008300.60336602
94Oxytocin signaling pathway_Homo sapiens_hsa049210.60321487
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59865828
96mRNA surveillance pathway_Homo sapiens_hsa030150.59559134
97African trypanosomiasis_Homo sapiens_hsa051430.57591881
98Insulin secretion_Homo sapiens_hsa049110.55360594
99Salivary secretion_Homo sapiens_hsa049700.55140098
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54857402
101Dorso-ventral axis formation_Homo sapiens_hsa043200.54631106
102ABC transporters_Homo sapiens_hsa020100.52864861
103Ovarian steroidogenesis_Homo sapiens_hsa049130.52381827
104Circadian rhythm_Homo sapiens_hsa047100.48664601
105Pyruvate metabolism_Homo sapiens_hsa006200.48569778
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48547761
107Pyrimidine metabolism_Homo sapiens_hsa002400.47259696
108Ras signaling pathway_Homo sapiens_hsa040140.47142232
109Chemical carcinogenesis_Homo sapiens_hsa052040.46680157
110p53 signaling pathway_Homo sapiens_hsa041150.46395975
111Regulation of autophagy_Homo sapiens_hsa041400.45732178
112beta-Alanine metabolism_Homo sapiens_hsa004100.43928168
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.42566662
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.40921935
115Hedgehog signaling pathway_Homo sapiens_hsa043400.40571388
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38696814
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37338579
118Ribosome_Homo sapiens_hsa030100.37279251
119Nucleotide excision repair_Homo sapiens_hsa034200.35383738
120MAPK signaling pathway_Homo sapiens_hsa040100.35339515
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34962380
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33529569
123Epstein-Barr virus infection_Homo sapiens_hsa051690.33075221
124Metabolic pathways_Homo sapiens_hsa011000.32578219
125Folate biosynthesis_Homo sapiens_hsa007900.32313552
126Salmonella infection_Homo sapiens_hsa051320.32056569
127Fat digestion and absorption_Homo sapiens_hsa049750.31817147
128Spliceosome_Homo sapiens_hsa030400.30834194
129GnRH signaling pathway_Homo sapiens_hsa049120.30769396
130Gap junction_Homo sapiens_hsa045400.30514775
131ErbB signaling pathway_Homo sapiens_hsa040120.29161713
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29093026
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28443090
134Alcoholism_Homo sapiens_hsa050340.28271435
135cAMP signaling pathway_Homo sapiens_hsa040240.28074391
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25301261
137Wnt signaling pathway_Homo sapiens_hsa043100.24694952
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24240968
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23681024
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21062835
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19462758
142Inositol phosphate metabolism_Homo sapiens_hsa005620.19295667
143Chemokine signaling pathway_Homo sapiens_hsa040620.18094410

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