POLD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.74088935
2antigen processing and presentation of endogenous antigen (GO:0019883)5.03056317
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.48402393
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.48402393
5regulation of B cell receptor signaling pathway (GO:0050855)4.33923575
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28745859
7negative regulation of cell killing (GO:0031342)4.28745859
8neutrophil activation involved in immune response (GO:0002283)4.28610586
9positive regulation of gamma-delta T cell activation (GO:0046645)4.27433954
10cellular response to zinc ion (GO:0071294)4.18155087
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.11998015
12immunoglobulin mediated immune response (GO:0016064)4.07807972
13B cell receptor signaling pathway (GO:0050853)4.06424573
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.89012003
15detection of bacterium (GO:0016045)3.85526676
16regulation of B cell differentiation (GO:0045577)3.83168242
17positive regulation of B cell differentiation (GO:0045579)3.80165623
18respiratory burst (GO:0045730)3.73436808
19positive regulation of interferon-alpha production (GO:0032727)3.71611921
20detection of other organism (GO:0098543)3.68710647
21cytidine metabolic process (GO:0046087)3.65514239
22cytidine catabolic process (GO:0006216)3.65514239
23cytidine deamination (GO:0009972)3.65514239
24defense response to protozoan (GO:0042832)3.64799907
25regulation of interferon-beta biosynthetic process (GO:0045357)3.57083815
26ribosomal small subunit assembly (GO:0000028)3.50521785
27regulation of interferon-alpha production (GO:0032647)3.49417598
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41499346
29sequestering of actin monomers (GO:0042989)3.40759203
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.37788666
31cellular response to interferon-beta (GO:0035458)3.37032136
32response to protozoan (GO:0001562)3.35673204
33response to type I interferon (GO:0034340)3.34076715
34type I interferon signaling pathway (GO:0060337)3.33012298
35cellular response to type I interferon (GO:0071357)3.33012298
36response to interferon-beta (GO:0035456)3.28263842
37B cell mediated immunity (GO:0019724)3.25068357
38positive thymic T cell selection (GO:0045059)3.17390376
39modulation by symbiont of host defense response (GO:0052031)3.16361743
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16361743
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16361743
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.16361743
43modulation by symbiont of host immune response (GO:0052553)3.16361743
44positive regulation by symbiont of host defense response (GO:0052509)3.16361743
45interferon-gamma-mediated signaling pathway (GO:0060333)3.15100727
46NIK/NF-kappaB signaling (GO:0038061)3.14179639
47leukocyte aggregation (GO:0070486)3.13513478
48response to peptidoglycan (GO:0032494)3.13008596
49cellular response to exogenous dsRNA (GO:0071360)3.12050993
50neutrophil activation (GO:0042119)3.09135253
51T-helper 1 type immune response (GO:0042088)3.09090229
52granulocyte activation (GO:0036230)3.03298995
53negative regulation of phagocytosis (GO:0050765)3.00966142
54mast cell activation (GO:0045576)2.99363588
55regulation of gamma-delta T cell differentiation (GO:0045586)2.98494071
56mature B cell differentiation (GO:0002335)2.97050541
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.96853625
58antigen processing and presentation via MHC class Ib (GO:0002475)2.96722062
59myeloid dendritic cell activation (GO:0001773)2.95933259
60positive regulation of natural killer cell differentiation (GO:0032825)2.94624876
61mature B cell differentiation involved in immune response (GO:0002313)2.91555132
62detection of external biotic stimulus (GO:0098581)2.90698657
63regulation of gamma-delta T cell activation (GO:0046643)2.90063627
64regulation of mast cell degranulation (GO:0043304)2.88975946
65positive regulation of antigen processing and presentation (GO:0002579)2.88813803
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.88525190
67positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88339421
68natural killer cell mediated immunity (GO:0002228)2.86656572
69natural killer cell mediated cytotoxicity (GO:0042267)2.86656572
70T cell migration (GO:0072678)2.86204336
71myeloid dendritic cell differentiation (GO:0043011)2.85446036
72macrophage activation involved in immune response (GO:0002281)2.84823895
73actin nucleation (GO:0045010)2.84730552
74germinal center formation (GO:0002467)2.83511614
75regulation of T cell mediated cytotoxicity (GO:0001914)2.83317000
76myeloid cell activation involved in immune response (GO:0002275)2.80722644
77lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78072513
78pyrimidine ribonucleoside catabolic process (GO:0046133)2.77033852
79negative regulation of interleukin-12 production (GO:0032695)2.70780862
80response to muramyl dipeptide (GO:0032495)2.66818685
81cellular response to interferon-gamma (GO:0071346)2.66622286
82positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.66053904
83lymph node development (GO:0048535)2.65940295
84negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.65214198
85regulation of cellular extravasation (GO:0002691)2.64864091
86positive regulation of cytokine biosynthetic process (GO:0042108)2.64424284
87negative regulation of innate immune response (GO:0045824)2.62103247
88positive regulation of interferon-beta production (GO:0032728)2.61887968
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58389614
90regulation of T-helper 1 cell differentiation (GO:0045625)2.57828887
91negative thymic T cell selection (GO:0045060)2.56750361
92positive regulation of macrophage differentiation (GO:0045651)2.56368912
93regulation of mast cell activation involved in immune response (GO:0033006)2.55960119
94T cell costimulation (GO:0031295)2.54391639
95viral transcription (GO:0019083)2.54307766
96response to interferon-gamma (GO:0034341)2.54255144
97positive regulation of interleukin-12 production (GO:0032735)2.53428657
98regulation of alpha-beta T cell proliferation (GO:0046640)2.53409119
99negative regulation of lymphocyte mediated immunity (GO:0002707)2.52619372
100regulation of myeloid leukocyte mediated immunity (GO:0002886)2.52353330
101positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52316699
102regulation of response to interferon-gamma (GO:0060330)2.52275119
103cellular extravasation (GO:0045123)2.51785768
104regulation of antigen processing and presentation (GO:0002577)2.50642215
105lymphocyte costimulation (GO:0031294)2.50302461
106negative regulation of leukocyte mediated immunity (GO:0002704)2.50227320
107negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.50169804
108response to host immune response (GO:0052572)2.50016416
109response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.50016416
110regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.49797974
111positive regulation of Cdc42 GTPase activity (GO:0043089)2.49590635
112amino sugar catabolic process (GO:0046348)2.48955381
113regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48895496
114production of molecular mediator involved in inflammatory response (GO:0002532)2.47335064
115positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.47045046
116JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46817658
117leukocyte mediated cytotoxicity (GO:0001909)2.45854074
118dendritic cell differentiation (GO:0097028)2.45674507
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.45338010
120regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.44582455
121detection of biotic stimulus (GO:0009595)2.44467304
122GDP-mannose metabolic process (GO:0019673)2.43886454
123positive regulation of chemokine biosynthetic process (GO:0045080)2.43537221
124natural killer cell differentiation (GO:0001779)2.42961874
125regulation of leukocyte degranulation (GO:0043300)2.42623575
126response to interferon-alpha (GO:0035455)2.42529430
127positive regulation of lamellipodium assembly (GO:0010592)2.42265498
128regulation of T cell receptor signaling pathway (GO:0050856)2.41952661
129hydrogen peroxide biosynthetic process (GO:0050665)2.41795690
130regulation of chemokine biosynthetic process (GO:0045073)2.41536106
131negative T cell selection (GO:0043383)2.40931901
132regulation of mast cell activation (GO:0033003)2.38533797
133thymic T cell selection (GO:0045061)2.38306776
134response to host (GO:0075136)2.37900004
135response to host defenses (GO:0052200)2.37900004
136response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.37900004
137negative regulation of cytokine production involved in immune response (GO:0002719)2.37377908
138interferon-gamma secretion (GO:0072643)2.36981929
139negative regulation of interleukin-6 production (GO:0032715)2.34615280
140T cell selection (GO:0045058)2.34512661
141positive regulation of mast cell activation (GO:0033005)2.33142089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.63210762
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.39806930
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.99932100
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.56723051
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.24795142
6* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.20852462
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20641582
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74184818
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.70058291
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56350635
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53099182
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51905750
13* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.41822851
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40146897
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.36936126
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35900535
17MYC_22102868_ChIP-Seq_BL_Human2.34865815
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31778980
19VDR_21846776_ChIP-Seq_THP-1_Human2.29700534
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24668682
21* SPI1_23547873_ChIP-Seq_NB4_Human2.23373523
22* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21377182
23LXR_22292898_ChIP-Seq_THP-1_Human2.17974069
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09609497
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05425315
26SCL_19346495_ChIP-Seq_HPC-7_Human2.03047618
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01783739
28MYB_26560356_Chip-Seq_TH2_Human1.99707316
29* MAF_26560356_Chip-Seq_TH1_Human1.97073666
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91720956
31* VDR_24763502_ChIP-Seq_THP-1_Human1.90270273
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86926825
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84722206
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.80624903
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80319526
36MYB_26560356_Chip-Seq_TH1_Human1.74099248
37* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72242999
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71219681
39E2F7_22180533_ChIP-Seq_HELA_Human1.70398776
40RUNX_20019798_ChIP-Seq_JUKART_Human1.67797066
41BCOR_27268052_Chip-Seq_Bcells_Human1.65580699
42UTX_26944678_Chip-Seq_JUKART_Human1.60361618
43* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58660392
44* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55077836
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53266908
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52897060
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52150952
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48025658
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.44349375
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43357520
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42413448
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41611313
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41270598
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39892642
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39088463
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.38696424
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38372779
58* SPI1_23127762_ChIP-Seq_K562_Human1.38266604
59* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38058024
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35727194
61* RACK7_27058665_Chip-Seq_MCF-7_Human1.35090333
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34548497
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34363158
64* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32147114
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31481097
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30970015
67* MAF_26560356_Chip-Seq_TH2_Human1.30642684
68GATA1_22025678_ChIP-Seq_K562_Human1.30355935
69* P68_20966046_ChIP-Seq_HELA_Human1.29153716
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29026958
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27313904
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27277498
73* ELK3_25401928_ChIP-Seq_HUVEC_Human1.26691389
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26619820
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26222341
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24320083
77* TET1_21451524_ChIP-Seq_MESCs_Mouse1.22766350
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.22750890
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21999984
80KDM2B_26808549_Chip-Seq_DND41_Human1.21955307
81TCF7_22412390_ChIP-Seq_EML_Mouse1.21824848
82PU_27001747_Chip-Seq_BMDM_Mouse1.19565420
83STAT1_20625510_ChIP-Seq_HELA_Human1.17550670
84* P300_27268052_Chip-Seq_Bcells_Human1.16945373
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16771161
86GATA3_27048872_Chip-Seq_THYMUS_Human1.16498271
87E2F1_20622854_ChIP-Seq_HELA_Human1.16430015
88* SA1_27219007_Chip-Seq_ERYTHROID_Human1.15468535
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15086732
90* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15084379
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14491397
92VDR_23849224_ChIP-Seq_CD4+_Human1.14113583
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13409721
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12482890
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.10942102
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10220773
97* CTCF_26484167_Chip-Seq_Bcells_Mouse1.09233309
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08704228
99SA1_27219007_Chip-Seq_Bcells_Human1.08041019
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07838025
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07796107
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07226595
103* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07170840
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05792170
105PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05764874
106TFEB_21752829_ChIP-Seq_HELA_Human1.04544306
107SPI1_20517297_ChIP-Seq_HL60_Human1.04111887
108* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02821950
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02545810
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02328945
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.02233164
112* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01471694
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01294218
114* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01208492
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97030948
116EST1_17652178_ChIP-ChIP_JURKAT_Human0.96503521
117FOXP3_21729870_ChIP-Seq_TREG_Human0.95269437
118* GATA3_26560356_Chip-Seq_TH2_Human0.94910328
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94142660
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.93600924
121* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92170730
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92001522
123BCL6_27268052_Chip-Seq_Bcells_Human0.91734455
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89421647
125RXR_22158963_ChIP-Seq_LIVER_Mouse0.89261130
126CIITA_25753668_ChIP-Seq_RAJI_Human0.88646881
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87874998
128ELK1_19687146_ChIP-ChIP_HELA_Human0.86229407
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.84499306
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84055199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.92190713
2MP0000685_abnormal_immune_system3.42494336
3MP0009785_altered_susceptibility_to3.35074424
4MP0003436_decreased_susceptibility_to3.27455541
5MP0001790_abnormal_immune_system3.16686288
6MP0005387_immune_system_phenotype3.16686288
7MP0001800_abnormal_humoral_immune3.15300560
8MP0002148_abnormal_hypersensitivity_rea3.06667430
9MP0005000_abnormal_immune_tolerance3.05954499
10MP0005671_abnormal_response_to3.00605238
11MP0002452_abnormal_antigen_presenting2.87830596
12MP0005025_abnormal_response_to2.73388310
13MP0002723_abnormal_immune_serum2.66014322
14MP0002419_abnormal_innate_immunity2.61173672
15MP0002139_abnormal_hepatobiliary_system2.53237666
16MP0002420_abnormal_adaptive_immunity2.50442211
17MP0001819_abnormal_immune_cell2.48603245
18MP0003303_peritoneal_inflammation2.31366114
19MP0003724_increased_susceptibility_to2.22219215
20MP0006082_CNS_inflammation2.18413967
21MP0002398_abnormal_bone_marrow2.12447940
22MP0003806_abnormal_nucleotide_metabolis2.12169198
23MP0005464_abnormal_platelet_physiology2.07887469
24MP0002405_respiratory_system_inflammati2.07035222
25MP0005360_urolithiasis2.06932524
26MP0001853_heart_inflammation2.06881096
27MP0009333_abnormal_splenocyte_physiolog2.05020391
28MP0000716_abnormal_immune_system2.03549235
29MP0002166_altered_tumor_susceptibility1.96612909
30MP0003763_abnormal_thymus_physiology1.94546733
31MP0001845_abnormal_inflammatory_respons1.87448450
32MP0005451_abnormal_body_composition1.87210898
33MP0000689_abnormal_spleen_morphology1.85396740
34MP0010155_abnormal_intestine_physiology1.81931877
35MP0002429_abnormal_blood_cell1.72354217
36MP0001533_abnormal_skeleton_physiology1.72095431
37MP0004510_myositis1.71880367
38MP0002006_tumorigenesis1.71782389
39MP0002722_abnormal_immune_system1.71447939
40MP0002396_abnormal_hematopoietic_system1.67808332
41MP0004947_skin_inflammation1.60772620
42MP0008469_abnormal_protein_level1.59760913
43MP0002933_joint_inflammation1.55657520
44MP0005058_abnormal_lysosome_morphology1.53920515
45MP0003191_abnormal_cellular_cholesterol1.52541712
46MP0009840_abnormal_foam_cell1.40362863
47MP0003300_gastrointestinal_ulcer1.40070470
48MP0005365_abnormal_bile_salt1.39165621
49MP0009764_decreased_sensitivity_to1.38881685
50MP0000858_altered_metastatic_potential1.38318158
51MP0001873_stomach_inflammation1.36941086
52MP0000343_altered_response_to1.35893579
53MP0004808_abnormal_hematopoietic_stem1.31369943
54MP0001545_abnormal_hematopoietic_system1.30424063
55MP0005397_hematopoietic_system_phenotyp1.30424063
56MP0003866_abnormal_defecation1.23481303
57MP0005310_abnormal_salivary_gland1.23160848
58MP0003186_abnormal_redox_activity1.23111987
59MP0005085_abnormal_gallbladder_physiolo1.20685296
60MP0008260_abnormal_autophagy1.19272246
61MP0000490_abnormal_crypts_of1.09165161
62MP0000703_abnormal_thymus_morphology1.08205121
63MP0003448_altered_tumor_morphology1.04733787
64MP0002998_abnormal_bone_remodeling1.03158515
65MP0003172_abnormal_lysosome_physiology1.03150930
66MP0000604_amyloidosis1.02346304
67MP0000465_gastrointestinal_hemorrhage1.01620667
68MP0006054_spinal_hemorrhage1.01532164
69MP0002138_abnormal_hepatobiliary_system0.98214304
70MP0008438_abnormal_cutaneous_collagen0.98167761
71MP0009278_abnormal_bone_marrow0.95662840
72MP0002019_abnormal_tumor_incidence0.92596769
73MP0003279_aneurysm0.92371029
74MP0009763_increased_sensitivity_to0.90549675
75MP0005174_abnormal_tail_pigmentation0.89143642
76MP0001666_abnormal_nutrient_absorption0.86257129
77MP0005381_digestive/alimentary_phenotyp0.85177300
78MP0005166_decreased_susceptibility_to0.83401156
79MP0001764_abnormal_homeostasis0.83310096
80MP0002136_abnormal_kidney_physiology0.83130843
81MP0004019_abnormal_vitamin_homeostasis0.82331410
82MP0003656_abnormal_erythrocyte_physiolo0.81717645
83MP0000249_abnormal_blood_vessel0.81254747
84MP0008875_abnormal_xenobiotic_pharmacok0.80892254
85MP0005390_skeleton_phenotype0.80280446
86MP0003566_abnormal_cell_adhesion0.79417015
87MP0003183_abnormal_peptide_metabolism0.79071014
88MP0004883_abnormal_blood_vessel0.78511327
89MP0003075_altered_response_to0.77279941
90MP0002132_abnormal_respiratory_system0.75821607
91MP0005165_increased_susceptibility_to0.74725465
92MP0000609_abnormal_liver_physiology0.73275742
93MP0010307_abnormal_tumor_latency0.72812529
94MP0009643_abnormal_urine_homeostasis0.72525801
95MP0005023_abnormal_wound_healing0.72253458
96MP0010329_abnormal_lipoprotein_level0.71735378
97MP0005584_abnormal_enzyme/coenzyme_acti0.71044567
98MP0003828_pulmonary_edema0.70506532
99MP0000598_abnormal_liver_morphology0.70119094
100MP0008004_abnormal_stomach_pH0.69107093
101MP0003252_abnormal_bile_duct0.68566377
102MP0005319_abnormal_enzyme/_coenzyme0.67204107
103MP0001663_abnormal_digestive_system0.65486482
104MP0002118_abnormal_lipid_homeostasis0.64998256
105MP0004782_abnormal_surfactant_physiolog0.64305120
106MP0001348_abnormal_lacrimal_gland0.63620501
107MP0003795_abnormal_bone_structure0.63566588
108MP0008874_decreased_physiological_sensi0.63302025
109MP0001986_abnormal_taste_sensitivity0.63135445
110MP0001851_eye_inflammation0.62526345
111MP0002277_abnormal_respiratory_mucosa0.61404756
112MP0010352_gastrointestinal_tract_polyps0.61235473
113MP0009642_abnormal_blood_homeostasis0.60107940
114MP0002254_reproductive_system_inflammat0.58475039
115MP0005075_abnormal_melanosome_morpholog0.57934091
116MP0001958_emphysema0.57534373
117MP0005164_abnormal_response_to0.55911586
118MP0008873_increased_physiological_sensi0.54675069
119MP0000015_abnormal_ear_pigmentation0.53840309
120MP0003045_fibrosis0.53570965
121MP0003091_abnormal_cell_migration0.53304440
122MP0002693_abnormal_pancreas_physiology0.52237201
123MP0002135_abnormal_kidney_morphology0.51929224
124MP0001542_abnormal_bone_strength0.51197376

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.22831250
2Recurrent bacterial skin infections (HP:0005406)4.85276346
3Eczematoid dermatitis (HP:0000976)4.79999525
4Agammaglobulinemia (HP:0004432)4.65105396
5Elevated erythrocyte sedimentation rate (HP:0003565)4.53774152
6Cellulitis (HP:0100658)4.26469370
7Recurrent bronchitis (HP:0002837)4.08852910
8Autoimmune thrombocytopenia (HP:0001973)3.92897127
9Gastrointestinal stroma tumor (HP:0100723)3.91864966
10Abnormality of liposaccharide metabolism (HP:0010968)3.90975994
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.90975994
12Abnormality of glycolipid metabolism (HP:0010969)3.90975994
13Recurrent gram-negative bacterial infections (HP:0005420)3.85973010
14IgM deficiency (HP:0002850)3.78215335
15Myositis (HP:0100614)3.78184578
16Recurrent fungal infections (HP:0002841)3.65964269
17Recurrent viral infections (HP:0004429)3.61228622
18Recurrent skin infections (HP:0001581)3.60250940
19Meningitis (HP:0001287)3.55901397
20Vasculitis (HP:0002633)3.54556527
21Thrombocytosis (HP:0001894)3.54322072
22Mediastinal lymphadenopathy (HP:0100721)3.39872127
23Vacuolated lymphocytes (HP:0001922)3.28575225
24Abnormality of macrophages (HP:0004311)3.25984693
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.24702585
26Chronic mucocutaneous candidiasis (HP:0002728)3.19667479
27Recurrent cutaneous fungal infections (HP:0011370)3.19667479
28Interstitial pulmonary disease (HP:0006530)3.18775942
29Lymphopenia (HP:0001888)3.07814998
30Petechiae (HP:0000967)3.07504602
31Abnormality of cells of the lymphoid lineage (HP:0012140)3.07074442
32Recurrent lower respiratory tract infections (HP:0002783)3.06550439
33Chronic otitis media (HP:0000389)3.06327886
34Abnormality of T cell physiology (HP:0011840)3.03294442
35Inflammation of the large intestine (HP:0002037)3.01986821
36Recurrent pneumonia (HP:0006532)3.01519151
37Osteomyelitis (HP:0002754)2.94548081
38Gastrointestinal inflammation (HP:0004386)2.93768860
39Chronic obstructive pulmonary disease (HP:0006510)2.92210114
40Obstructive lung disease (HP:0006536)2.92210114
41Colitis (HP:0002583)2.91118148
42Abnormality of T cells (HP:0002843)2.84560036
43Papilloma (HP:0012740)2.84428744
44Verrucae (HP:0200043)2.84428744
45Orchitis (HP:0100796)2.83820643
46Panhypogammaglobulinemia (HP:0003139)2.79038264
47Recurrent sinusitis (HP:0011108)2.76593256
48IgA deficiency (HP:0002720)2.65868172
49Systemic lupus erythematosus (HP:0002725)2.62792558
50Emphysema (HP:0002097)2.62774054
51Pustule (HP:0200039)2.62206294
52Malnutrition (HP:0004395)2.61522149
53Abnormality of T cell number (HP:0011839)2.59906274
54IgG deficiency (HP:0004315)2.56238741
55Abnormality of polysaccharide metabolism (HP:0011012)2.53338203
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.53338203
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.53338203
58Vertebral compression fractures (HP:0002953)2.52633218
59Gingival bleeding (HP:0000225)2.47384849
60Optic neuritis (HP:0100653)2.44572411
61Retrobulbar optic neuritis (HP:0100654)2.44572411
62Purpura (HP:0000979)2.44428159
63Chronic sinusitis (HP:0011109)2.43963961
64Gingivitis (HP:0000230)2.43958160
65Sepsis (HP:0100806)2.41976292
66Increased serum ferritin (HP:0003281)2.41386447
67Spontaneous hematomas (HP:0007420)2.41048523
68Pulmonary infiltrates (HP:0002113)2.40597582
69Urticaria (HP:0001025)2.39429891
70T lymphocytopenia (HP:0005403)2.36887027
71Gastrointestinal infarctions (HP:0005244)2.36667905
72Hypergammaglobulinemia (HP:0010702)2.35849811
73Abnormality of B cell number (HP:0010975)2.35201350
74B lymphocytopenia (HP:0010976)2.35201350
75Thyroiditis (HP:0100646)2.31980743
76Periodontitis (HP:0000704)2.29109306
77Skin rash (HP:0000988)2.26346202
78Restrictive lung disease (HP:0002091)2.26067641
79Nasal polyposis (HP:0100582)2.25673545
80Basal ganglia calcification (HP:0002135)2.21628264
81Epistaxis (HP:0000421)2.21379061
82Arterial thrombosis (HP:0004420)2.21183833
83Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20019278
84Poor head control (HP:0002421)2.20011275
85Increased IgM level (HP:0003496)2.17548677
86Hypertensive crisis (HP:0100735)2.14779088
87Skin ulcer (HP:0200042)2.14178276
88Chronic diarrhea (HP:0002028)2.12829920
89Leukocytosis (HP:0001974)2.12464243
90Hepatosplenomegaly (HP:0001433)2.11498975
91Bronchitis (HP:0012387)2.10689735
92Loss of speech (HP:0002371)2.10016727
93Neutropenia (HP:0001875)2.09965119
94Amyloidosis (HP:0011034)2.09894119
95Granulocytopenia (HP:0001913)2.09805555
96Dysostosis multiplex (HP:0000943)2.09689591
97Axonal loss (HP:0003447)2.09080646
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.08754758
99Abnormality of iron homeostasis (HP:0011031)2.08163825
100Abnormality of the nasal mucosa (HP:0000433)2.08155209
101Encephalitis (HP:0002383)2.05963598
102Arthralgia (HP:0002829)2.05936069
103Combined immunodeficiency (HP:0005387)2.05817980
104Stomatitis (HP:0010280)2.05520907
105Increased cerebral lipofuscin (HP:0011813)2.03359724
106Prolonged bleeding time (HP:0003010)1.98167399
107Hemoptysis (HP:0002105)1.97889018
108Mitral stenosis (HP:0001718)1.97852899
109Hemorrhage of the eye (HP:0011885)1.96429474
110Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96123854
111Chest pain (HP:0100749)1.95489921
112Myocardial infarction (HP:0001658)1.94296259
113Mucopolysacchariduria (HP:0008155)1.93970824
114Urinary glycosaminoglycan excretion (HP:0003541)1.93970824
115Increased IgE level (HP:0003212)1.93666297
116Glomerulonephritis (HP:0000099)1.92734697
117Abnormality of the pleura (HP:0002103)1.92489559
118Progressive neurologic deterioration (HP:0002344)1.92058549
119Severe combined immunodeficiency (HP:0004430)1.91616259
120Lymphoma (HP:0002665)1.90237353
121Prolonged neonatal jaundice (HP:0006579)1.90112301
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89567398
123Eosinophilia (HP:0001880)1.89068809
124Abnormality of complement system (HP:0005339)1.88191557
125Premature loss of primary teeth (HP:0006323)1.86967783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.69866569
2ERN13.55554225
3BLK3.34386837
4TBK12.82586086
5MAP3K142.57938472
6KIT2.51494603
7BTK2.47604008
8NME22.36346724
9TYK22.34597453
10PIM22.32137742
11JAK32.17300913
12CSF1R2.12842044
13ZAP702.12390804
14IKBKE2.11931856
15SYK2.08670103
16IRAK41.97602443
17IKBKB1.89511095
18TLK11.86203220
19TEC1.85573862
20LRRK21.63349444
21IRAK31.62122251
22RIPK41.61923084
23FLT31.60959087
24TXK1.56571028
25MAP2K31.55334061
26TRIB31.55161270
27PRPF4B1.47410579
28MAP3K101.45141395
29JAK11.42673341
30GRK61.41289458
31LYN1.41104131
32STK101.37217368
33EPHA21.33942701
34NEK91.31395931
35RPS6KA41.29786274
36TESK11.28645142
37TESK21.23822325
38TAOK21.23424619
39TAOK11.22185714
40CSK1.18887233
41CHUK1.18582926
42LCK1.17101368
43ITK1.16262208
44PIK3CG1.12922034
45KDR1.11367891
46HCK1.11332268
47PIM11.08717673
48TGFBR21.06012371
49MAP3K11.06005189
50PKN21.05301338
51FGFR41.02304169
52ACVR1B0.97968416
53MAP3K130.96142124
54MATK0.94145848
55PRKD20.93932752
56ARAF0.90583626
57MST1R0.88292667
58EEF2K0.86614152
59EIF2AK10.84192674
60CDC42BPA0.83326533
61SCYL20.82630575
62TAOK30.81486496
63MAP2K20.81224024
64MST40.79433411
65MAP3K110.77529808
66SIK30.77217500
67EIF2AK30.75690221
68CLK10.72817480
69NLK0.72448022
70BMPR20.72372636
71MAP2K60.71043201
72GRK70.70945109
73BCKDK0.69959847
74PDPK10.69619067
75BUB10.69131570
76CDK190.68326810
77PDK10.66295018
78FGFR30.65988502
79FGR0.65319927
80HIPK20.65141836
81MAPK120.64399908
82SMG10.64395870
83MAP3K120.63406208
84ILK0.63087998
85MAPK70.61779884
86TRPM70.60479395
87MAP3K30.60164124
88STK40.60034433
89TGFBR10.59433188
90PRKCQ0.57394639
91EPHB10.57243351
92MYLK0.56828699
93JAK20.55698338
94MAPKAPK20.55263194
95MARK30.54535389
96PRKCD0.54292080
97LMTK20.51916798
98SIK10.50405046
99ABL20.50364070
100RPS6KA60.49835045
101TNK20.49686993
102ADRBK20.49403803
103VRK20.47829759
104MAPK110.47123887
105FES0.45573440
106PRKCH0.44525601
107EPHA30.44349131
108EPHB20.44057968
109DDR20.42474381
110SIK20.42473744
111PBK0.42073689
112ABL10.41169426
113ADRBK10.41075593
114MAPKAPK30.38896115
115LIMK10.38557318
116FYN0.38506605
117MAPK40.35834406
118MAP3K80.35286833
119PAK40.34801309
120PTK60.34323168
121IRAK10.34017651
122RPS6KC10.31946106
123RPS6KL10.31946106
124MOS0.30621333
125CDK40.29903440
126PRKG20.29708687
127DAPK30.28483569
128DYRK1B0.27812839
129RAF10.26950721

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.61145086
2Leishmaniasis_Homo sapiens_hsa051402.90524696
3B cell receptor signaling pathway_Homo sapiens_hsa046622.78082255
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.63438193
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.52303005
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51984674
7Graft-versus-host disease_Homo sapiens_hsa053322.25743301
8Allograft rejection_Homo sapiens_hsa053302.19406366
9Antigen processing and presentation_Homo sapiens_hsa046122.17344310
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08701705
11Measles_Homo sapiens_hsa051622.08658507
12Legionellosis_Homo sapiens_hsa051342.07649940
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06675538
14Ribosome_Homo sapiens_hsa030102.04008910
15Osteoclast differentiation_Homo sapiens_hsa043802.03678642
16Hematopoietic cell lineage_Homo sapiens_hsa046401.98067642
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93384068
18Staphylococcus aureus infection_Homo sapiens_hsa051501.76327198
19Tuberculosis_Homo sapiens_hsa051521.72445875
20Pertussis_Homo sapiens_hsa051331.70578878
21Malaria_Homo sapiens_hsa051441.64735597
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61719642
23Asthma_Homo sapiens_hsa053101.59256833
24Other glycan degradation_Homo sapiens_hsa005111.57310766
25Shigellosis_Homo sapiens_hsa051311.55554037
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.52216005
27Herpes simplex infection_Homo sapiens_hsa051681.49261941
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47658907
29Proteasome_Homo sapiens_hsa030501.45912844
30Apoptosis_Homo sapiens_hsa042101.41957780
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.40818557
32Influenza A_Homo sapiens_hsa051641.40334621
33Lysosome_Homo sapiens_hsa041421.37480468
34Toxoplasmosis_Homo sapiens_hsa051451.35953219
35Caffeine metabolism_Homo sapiens_hsa002321.34931757
36Salmonella infection_Homo sapiens_hsa051321.30643739
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26453352
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25381236
39Rheumatoid arthritis_Homo sapiens_hsa053231.23798277
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23754508
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.23083010
42Type I diabetes mellitus_Homo sapiens_hsa049401.22121001
43TNF signaling pathway_Homo sapiens_hsa046681.20128479
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14921164
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13489147
46Viral myocarditis_Homo sapiens_hsa054161.13216467
47Fructose and mannose metabolism_Homo sapiens_hsa000511.05694359
48Sulfur metabolism_Homo sapiens_hsa009201.04765275
49Hepatitis B_Homo sapiens_hsa051611.03364529
50Protein export_Homo sapiens_hsa030601.02518652
51T cell receptor signaling pathway_Homo sapiens_hsa046600.99978831
52Chemokine signaling pathway_Homo sapiens_hsa040620.99857811
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99247686
54Phagosome_Homo sapiens_hsa041450.98302982
55Acute myeloid leukemia_Homo sapiens_hsa052210.96979902
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.96549207
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96013658
58African trypanosomiasis_Homo sapiens_hsa051430.94508736
59Arachidonic acid metabolism_Homo sapiens_hsa005900.91135253
60* DNA replication_Homo sapiens_hsa030300.89803322
61* Base excision repair_Homo sapiens_hsa034100.89274668
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88896497
63Epstein-Barr virus infection_Homo sapiens_hsa051690.86864473
64Pentose phosphate pathway_Homo sapiens_hsa000300.86690381
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82105915
66Autoimmune thyroid disease_Homo sapiens_hsa053200.78736436
67Fat digestion and absorption_Homo sapiens_hsa049750.78592219
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77772617
69Platelet activation_Homo sapiens_hsa046110.77359616
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73885592
71Chemical carcinogenesis_Homo sapiens_hsa052040.72338336
72Hepatitis C_Homo sapiens_hsa051600.70886999
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70431388
74Renin-angiotensin system_Homo sapiens_hsa046140.69848869
75Mineral absorption_Homo sapiens_hsa049780.68023763
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65936571
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64437878
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64307967
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63781634
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63612461
81Complement and coagulation cascades_Homo sapiens_hsa046100.61499041
82Chronic myeloid leukemia_Homo sapiens_hsa052200.59425455
83PPAR signaling pathway_Homo sapiens_hsa033200.57800642
84p53 signaling pathway_Homo sapiens_hsa041150.57281544
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57185398
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57000733
87Vitamin digestion and absorption_Homo sapiens_hsa049770.56904763
88Viral carcinogenesis_Homo sapiens_hsa052030.56138380
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54090083
90Pancreatic cancer_Homo sapiens_hsa052120.53475961
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.52316927
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.50153292
93Linoleic acid metabolism_Homo sapiens_hsa005910.50123186
94Galactose metabolism_Homo sapiens_hsa000520.48738615
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48497944
96Starch and sucrose metabolism_Homo sapiens_hsa005000.47194686
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.46348173
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45837426
99Sulfur relay system_Homo sapiens_hsa041220.44212401
100Glutathione metabolism_Homo sapiens_hsa004800.43980575
101* Pyrimidine metabolism_Homo sapiens_hsa002400.42123061
102Prolactin signaling pathway_Homo sapiens_hsa049170.41621960
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41436692
104Retinol metabolism_Homo sapiens_hsa008300.41429927
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.41298112
106N-Glycan biosynthesis_Homo sapiens_hsa005100.40500374
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39442756
108* HTLV-I infection_Homo sapiens_hsa051660.38961714
109Folate biosynthesis_Homo sapiens_hsa007900.38642175
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.38365037
111Phenylalanine metabolism_Homo sapiens_hsa003600.36172028
112Collecting duct acid secretion_Homo sapiens_hsa049660.36059424
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35855431
114HIF-1 signaling pathway_Homo sapiens_hsa040660.35445961
115Amoebiasis_Homo sapiens_hsa051460.33523626
116Glycerolipid metabolism_Homo sapiens_hsa005610.33196725
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.32278789
118Endocytosis_Homo sapiens_hsa041440.31392916
119Small cell lung cancer_Homo sapiens_hsa052220.31340310
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30056921
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25352133
122Non-homologous end-joining_Homo sapiens_hsa034500.25052422
123Insulin resistance_Homo sapiens_hsa049310.24144750
124Systemic lupus erythematosus_Homo sapiens_hsa053220.23888510
125Peroxisome_Homo sapiens_hsa041460.22970048
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22304773
127Histidine metabolism_Homo sapiens_hsa003400.20460693
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19685034

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