POLDIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)4.76963885
2lysine catabolic process (GO:0006554)4.76963885
3COPI coating of Golgi vesicle (GO:0048205)4.72979344
4Golgi transport vesicle coating (GO:0048200)4.72979344
5glyoxylate metabolic process (GO:0046487)4.72346878
6L-phenylalanine metabolic process (GO:0006558)4.65668620
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.65668620
8L-phenylalanine catabolic process (GO:0006559)4.41671363
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.41671363
10tricarboxylic acid cycle (GO:0006099)4.38036564
11nucleobase-containing small molecule interconversion (GO:0015949)4.36365322
12glycine metabolic process (GO:0006544)4.33386362
13aspartate family amino acid catabolic process (GO:0009068)4.30596323
14branched-chain amino acid catabolic process (GO:0009083)4.29845049
15proline biosynthetic process (GO:0006561)4.24211924
16response to muscle activity (GO:0014850)4.17487284
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06357946
18serine family amino acid biosynthetic process (GO:0009070)4.06245295
19protein retention in ER lumen (GO:0006621)4.05057927
20fatty acid beta-oxidation (GO:0006635)4.02232762
21nucleoside diphosphate biosynthetic process (GO:0009133)4.00154853
22negative regulation of cell size (GO:0045792)3.99310241
23gluconeogenesis (GO:0006094)3.95038339
24serine family amino acid catabolic process (GO:0009071)3.88125858
25serine family amino acid metabolic process (GO:0009069)3.85875727
262-oxoglutarate metabolic process (GO:0006103)3.84368304
27cysteine metabolic process (GO:0006534)3.84138488
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.82353222
29hexose biosynthetic process (GO:0019319)3.81310129
30DNA deamination (GO:0045006)3.80861154
31acetyl-CoA metabolic process (GO:0006084)3.77713401
32aromatic amino acid family catabolic process (GO:0009074)3.75316976
33ATP synthesis coupled proton transport (GO:0015986)3.75194497
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75194497
35amino-acid betaine metabolic process (GO:0006577)3.74724898
36branched-chain amino acid metabolic process (GO:0009081)3.72755321
37monosaccharide biosynthetic process (GO:0046364)3.70800973
38AMP metabolic process (GO:0046033)3.69570286
39L-serine metabolic process (GO:0006563)3.69194892
40retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.68569919
41actin-myosin filament sliding (GO:0033275)3.67837927
42muscle filament sliding (GO:0030049)3.67837927
43oxidative phosphorylation (GO:0006119)3.67051123
44kynurenine metabolic process (GO:0070189)3.66116751
45short-chain fatty acid metabolic process (GO:0046459)3.63647093
46carnitine shuttle (GO:0006853)3.63395031
47alpha-linolenic acid metabolic process (GO:0036109)3.60703118
48fatty acid catabolic process (GO:0009062)3.57527128
49protein complex localization (GO:0031503)3.56862048
50fatty acid oxidation (GO:0019395)3.55480526
51regulation of oxidative phosphorylation (GO:0002082)3.54496879
52sulfur amino acid catabolic process (GO:0000098)3.54021938
53regulation of translational fidelity (GO:0006450)3.52570766
54peptidyl-arginine omega-N-methylation (GO:0035247)3.51017746
55alpha-amino acid catabolic process (GO:1901606)3.50279988
56triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.47958708
57regulation of oxidative stress-induced neuron death (GO:1903203)3.47804037
58lipid oxidation (GO:0034440)3.46867873
59fatty acid transmembrane transport (GO:1902001)3.46455252
60protein maturation by protein folding (GO:0022417)3.46176719
61negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.45248274
62biotin metabolic process (GO:0006768)3.42007337
63cellular amino acid catabolic process (GO:0009063)3.38889446
64folic acid metabolic process (GO:0046655)3.38881903
65muscle cell cellular homeostasis (GO:0046716)3.38336974
66regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.37522427
67respiratory electron transport chain (GO:0022904)3.36164109
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35999965
69monocarboxylic acid catabolic process (GO:0072329)3.33926856
70ethanol oxidation (GO:0006069)3.32941530
71carnitine metabolic process (GO:0009437)3.32455682
72cellular ketone body metabolic process (GO:0046950)3.32190773
73negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.29732372
74valine metabolic process (GO:0006573)3.29538769
75NADH metabolic process (GO:0006734)3.29256848
76glycolytic process (GO:0006096)3.29192835
77mitotic chromosome condensation (GO:0007076)3.29057563
78bile acid biosynthetic process (GO:0006699)3.26740066
79electron transport chain (GO:0022900)3.26458325
80tryptophan catabolic process (GO:0006569)3.25093922
81indole-containing compound catabolic process (GO:0042436)3.25093922
82indolalkylamine catabolic process (GO:0046218)3.25093922
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.24579882
84carboxylic acid catabolic process (GO:0046395)3.24003545
85organic acid catabolic process (GO:0016054)3.24003545
86regulation of triglyceride catabolic process (GO:0010896)3.22930089
87aspartate family amino acid metabolic process (GO:0009066)3.19966501
88regulation of mitochondrial translation (GO:0070129)3.19776610
89negative regulation of response to reactive oxygen species (GO:1901032)3.18870479
90regulation of cellular respiration (GO:0043457)3.18545697
91positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18291488
92tricarboxylic acid metabolic process (GO:0072350)3.16424997
93quinone biosynthetic process (GO:1901663)3.12712627
94ubiquinone biosynthetic process (GO:0006744)3.12712627
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10293013
96proline metabolic process (GO:0006560)3.08857314
97fructose metabolic process (GO:0006000)3.07879131
98oxaloacetate metabolic process (GO:0006107)3.05663507
99sarcomere organization (GO:0045214)3.05375608
100amino-acid betaine transport (GO:0015838)3.04828521
101carnitine transport (GO:0015879)3.04828521
102regulation of cofactor metabolic process (GO:0051193)3.04426776
103regulation of coenzyme metabolic process (GO:0051196)3.04426776
104creatine metabolic process (GO:0006600)3.04076738
105homocysteine metabolic process (GO:0050667)3.03687612
106negative regulation of fibrinolysis (GO:0051918)3.02517258
107carnitine transmembrane transport (GO:1902603)3.02178353
108regulation of acyl-CoA biosynthetic process (GO:0050812)3.01307385
109mitochondrial fusion (GO:0008053)3.01251857
110response to mercury ion (GO:0046689)3.00362487
111cellular modified amino acid catabolic process (GO:0042219)2.99518158
112regulation of hydrogen peroxide-induced cell death (GO:1903205)2.98303012
113urea cycle (GO:0000050)2.98247913
114sulfur amino acid biosynthetic process (GO:0000097)2.98176013
115negative regulation of fatty acid biosynthetic process (GO:0045717)2.97673619
116tryptophan metabolic process (GO:0006568)2.97582322
117glutamine family amino acid biosynthetic process (GO:0009084)2.96584822
118aromatic amino acid family metabolic process (GO:0009072)2.96488468
119actin-mediated cell contraction (GO:0070252)2.96400190
120regulation of sequestering of triglyceride (GO:0010889)2.95825836
121regulation of fatty acid oxidation (GO:0046320)2.95638390
122glutamate metabolic process (GO:0006536)2.94545687
123ribosome assembly (GO:0042255)2.93994061
124GDP-mannose metabolic process (GO:0019673)2.93956781
125regulation of mammary gland epithelial cell proliferation (GO:0033599)2.93498868
126pentose-phosphate shunt (GO:0006098)2.93098721
127focal adhesion assembly (GO:0048041)2.92377606
128cell-substrate adherens junction assembly (GO:0007045)2.92377606
129urea metabolic process (GO:0019627)2.91842022
130dicarboxylic acid biosynthetic process (GO:0043650)2.90521221
131coenzyme catabolic process (GO:0009109)2.90153326
132DNA unwinding involved in DNA replication (GO:0006268)2.89574846
133ketone body metabolic process (GO:1902224)2.88906459
134dicarboxylic acid metabolic process (GO:0043648)2.88275601
1354-hydroxyproline metabolic process (GO:0019471)2.87411497
136imidazole-containing compound metabolic process (GO:0052803)2.85318378
137acylglycerol homeostasis (GO:0055090)2.84921855
138triglyceride homeostasis (GO:0070328)2.84921855
139folic acid-containing compound biosynthetic process (GO:0009396)2.83911187
140positive regulation of fatty acid beta-oxidation (GO:0032000)2.82854524
141negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.79311830
142spliceosomal tri-snRNP complex assembly (GO:0000244)2.79180181
143histone arginine methylation (GO:0034969)2.78796176
144regulation of fibrinolysis (GO:0051917)2.76998068
145myofibril assembly (GO:0030239)2.76126297
146adherens junction assembly (GO:0034333)2.74857033
1473-UTR-mediated mRNA stabilization (GO:0070935)2.74809122
148one-carbon metabolic process (GO:0006730)2.74757973
149small molecule catabolic process (GO:0044282)2.73980003
150succinate metabolic process (GO:0006105)2.73565805
151ubiquinone metabolic process (GO:0006743)2.72555337
152barbed-end actin filament capping (GO:0051016)2.72324477
153response to nitrosative stress (GO:0051409)2.72061995
154L-methionine salvage (GO:0071267)2.70653846
155L-methionine biosynthetic process (GO:0071265)2.70653846
156amino acid salvage (GO:0043102)2.70653846
157ribosomal small subunit biogenesis (GO:0042274)2.69195247
158ADP metabolic process (GO:0046031)2.68639778
159nitrogen cycle metabolic process (GO:0071941)2.68381980
160cellular protein complex localization (GO:0034629)2.67721307
161DNA strand elongation involved in DNA replication (GO:0006271)2.67374803
162formation of translation preinitiation complex (GO:0001731)2.67182388
163peptidyl-arginine methylation (GO:0018216)2.66336859
164peptidyl-arginine N-methylation (GO:0035246)2.66336859
165regulation of protein sumoylation (GO:0033233)2.64597040
166DNA strand elongation (GO:0022616)2.63772065
167NADPH regeneration (GO:0006740)2.61872254
168pyruvate metabolic process (GO:0006090)2.60542338
169glycogen metabolic process (GO:0005977)2.55253404
170glucose catabolic process (GO:0006007)2.54976663
171apoptotic process involved in morphogenesis (GO:0060561)2.54397168
172IMP metabolic process (GO:0046040)2.52833185
173negative regulation of necroptotic process (GO:0060546)2.50772393
174positive regulation of catecholamine secretion (GO:0033605)2.50220554
175heterochromatin organization (GO:0070828)2.49402073
176rRNA transcription (GO:0009303)2.49051511
177maternal placenta development (GO:0001893)2.48551014
178glucan metabolic process (GO:0044042)2.48041429
179cellular glucan metabolic process (GO:0006073)2.48041429
180telomere maintenance via semi-conservative replication (GO:0032201)2.45128166
181regulation of autophagic vacuole assembly (GO:2000785)2.44888232
182nuclear envelope reassembly (GO:0031468)2.42862471
183mitotic nuclear envelope reassembly (GO:0007084)2.42862471
184negative regulation of microtubule polymerization (GO:0031115)2.41537918
185regulation of translational termination (GO:0006449)2.41491762
186glutamine family amino acid catabolic process (GO:0009065)2.38990290
187negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.38387081
188purine nucleoside diphosphate metabolic process (GO:0009135)2.37835928
189purine ribonucleoside diphosphate metabolic process (GO:0009179)2.37835928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.82477707
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.47800367
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.60833221
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.60535467
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53693218
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.26088824
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65474755
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60742643
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.59428753
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.57702268
11* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53398490
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.50425131
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49611322
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.45132794
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.37080177
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32123434
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24852879
18LXR_22292898_ChIP-Seq_THP-1_Human2.22566990
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22416914
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18532482
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17942647
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09368141
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.08995908
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.08759271
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02047681
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.98991928
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95593463
28VDR_21846776_ChIP-Seq_THP-1_Human1.94035674
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.90639895
30MYC_22102868_ChIP-Seq_BL_Human1.87771440
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87625562
32RACK7_27058665_Chip-Seq_MCF-7_Human1.87089257
33XRN2_22483619_ChIP-Seq_HELA_Human1.86507486
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.85959526
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84224427
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81000800
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.75599221
38E2F7_22180533_ChIP-Seq_HELA_Human1.66313846
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65638018
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.65161534
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64249297
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61438354
43ZNF263_19887448_ChIP-Seq_K562_Human1.61325942
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60613048
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.59545725
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.58958817
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57694541
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57253327
49CLOCK_20551151_ChIP-Seq_293T_Human1.55262576
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54156916
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50566956
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50441414
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49629271
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.49345360
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47803110
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47705669
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46828864
58* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46120282
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45656707
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45275989
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43675581
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.40772056
63* DCP1A_22483619_ChIP-Seq_HELA_Human1.39863367
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39564639
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33146683
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31797254
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.30370960
68SMC4_20622854_ChIP-Seq_HELA_Human1.29448734
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28503958
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27913794
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26589278
72KDM2B_26808549_Chip-Seq_DND41_Human1.25729883
73* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25636485
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.25480930
75ATF3_27146783_Chip-Seq_COLON_Human1.24347236
76SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23048390
77* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22992674
78* GABP_19822575_ChIP-Seq_HepG2_Human1.22882471
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.21865382
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21492975
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20349275
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.19277977
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19268950
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18522677
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18281091
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17908550
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16770827
88FOXP3_21729870_ChIP-Seq_TREG_Human1.16422507
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14749075
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14416837
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13885650
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13743770
93KDM5A_27292631_Chip-Seq_BREAST_Human1.13002697
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11398063
95FOXP1_21924763_ChIP-Seq_HESCs_Human1.10716398
96TTF2_22483619_ChIP-Seq_HELA_Human1.09687004
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09331840
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.09204362
99CTCF_21964334_Chip-Seq_Bcells_Human1.08416076
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08223994
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07095258
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06421086
103* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06392437
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05941706
105VDR_23849224_ChIP-Seq_CD4+_Human1.05775475
106AR_21909140_ChIP-Seq_LNCAP_Human1.05614172
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04917046
108CHD1_26751641_Chip-Seq_LNCaP_Human1.04274554
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04248618
110* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03411425
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03193798
112CREB1_26743006_Chip-Seq_LNCaP_Human1.02702779
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.01397878
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01210759
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00262802
116NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99399658
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99230531
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99170505
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99146357
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98656721
121P68_20966046_ChIP-Seq_HELA_Human0.98383860
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98240062
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97960320
124TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97952515
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97429414
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96182571
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95237496
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93206991
129* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92385105
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92148456
131TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91107328
132E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90744874
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89470132
134TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88797114
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88308285
136* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88189378
137CIITA_25753668_ChIP-Seq_RAJI_Human0.85492193
138CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85470961
139SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84656474
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84581704
141POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84537065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.02653596
2MP0003806_abnormal_nucleotide_metabolis4.89828542
3MP0005360_urolithiasis4.29326068
4MP0005085_abnormal_gallbladder_physiolo3.70462631
5MP0005365_abnormal_bile_salt3.62331948
6MP0003646_muscle_fatigue3.37215453
7MP0002837_dystrophic_cardiac_calcinosis3.30460672
8MP0005058_abnormal_lysosome_morphology2.85619672
9MP0005670_abnormal_white_adipose2.69237417
10MP0008875_abnormal_xenobiotic_pharmacok2.68287645
11MP0005332_abnormal_amino_acid2.63610804
12MP0006036_abnormal_mitochondrial_physio2.41781987
13MP0009840_abnormal_foam_cell2.41106908
14MP0003195_calcinosis2.37173864
15MP0000751_myopathy2.31770325
16MP0010329_abnormal_lipoprotein_level2.30398956
17MP0003315_abnormal_perineum_morphology2.22699356
18MP0005330_cardiomyopathy2.18445733
19MP0004215_abnormal_myocardial_fiber2.15322822
20MP0010234_abnormal_vibrissa_follicle2.07365033
21MP0004084_abnormal_cardiac_muscle2.03577815
22MP0005083_abnormal_biliary_tract2.00103647
23MP0001849_ear_inflammation1.98005934
24MP0002877_abnormal_melanocyte_morpholog1.92241347
25MP0005666_abnormal_adipose_tissue1.91178738
26MP0003186_abnormal_redox_activity1.90244635
27MP0003252_abnormal_bile_duct1.88237417
28MP0000537_abnormal_urethra_morphology1.87412136
29MP0002269_muscular_atrophy1.86738031
30MP0004858_abnormal_nervous_system1.82255842
31MP0006035_abnormal_mitochondrial_morpho1.78275504
32MP0000749_muscle_degeneration1.78261151
33MP0000733_abnormal_muscle_development1.71875351
34MP0004130_abnormal_muscle_cell1.67943407
35MP0003137_abnormal_impulse_conducting1.66365222
36MP0004233_abnormal_muscle_weight1.64048283
37MP0004036_abnormal_muscle_relaxation1.62309380
38MP0004019_abnormal_vitamin_homeostasis1.60554285
39MP0000750_abnormal_muscle_regeneration1.53705982
40MP0005319_abnormal_enzyme/_coenzyme1.50806853
41MP0002118_abnormal_lipid_homeostasis1.49414732
42MP0000678_abnormal_parathyroid_gland1.44199790
43MP0004087_abnormal_muscle_fiber1.40110389
44MP0004145_abnormal_muscle_electrophysio1.35474553
45MP0002796_impaired_skin_barrier1.34155228
46MP0008260_abnormal_autophagy1.33378769
47MP0000747_muscle_weakness1.32823486
48MP0005266_abnormal_metabolism1.30868364
49MP0010368_abnormal_lymphatic_system1.29802722
50MP0004272_abnormal_basement_membrane1.28803981
51MP0003011_delayed_dark_adaptation1.28605713
52MP0008775_abnormal_heart_ventricle1.27316625
53MP0001764_abnormal_homeostasis1.26317242
54MP0003566_abnormal_cell_adhesion1.26183132
55MP0005584_abnormal_enzyme/coenzyme_acti1.24383316
56MP0001730_embryonic_growth_arrest1.23749067
57MP0005501_abnormal_skin_physiology1.23726491
58MP0005620_abnormal_muscle_contractility1.21980985
59MP0003221_abnormal_cardiomyocyte_apopto1.21892934
60MP0009780_abnormal_chondrocyte_physiolo1.21348062
61MP0009697_abnormal_copulation1.20143741
62MP0003077_abnormal_cell_cycle1.19870967
63MP0001666_abnormal_nutrient_absorption1.19461483
64MP0002249_abnormal_larynx_morphology1.17887579
65MP0000003_abnormal_adipose_tissue1.17640625
66MP0010094_abnormal_chromosome_stability1.16635252
67MP0005375_adipose_tissue_phenotype1.15919113
68MP0000609_abnormal_liver_physiology1.15513360
69MP0009643_abnormal_urine_homeostasis1.11704181
70MP0003718_maternal_effect1.10833385
71MP0000759_abnormal_skeletal_muscle1.09505383
72MP0005410_abnormal_fertilization1.07938440
73MP0004185_abnormal_adipocyte_glucose1.07533899
74MP0005623_abnormal_meninges_morphology1.07419039
75MP0004133_heterotaxia1.06863750
76MP0002972_abnormal_cardiac_muscle1.06720366
77MP0004043_abnormal_pH_regulation1.06007347
78MP0002106_abnormal_muscle_physiology1.04648149
79MP0005076_abnormal_cell_differentiation1.02430877
80MP0001661_extended_life_span1.01352662
81MP0001544_abnormal_cardiovascular_syste1.00889059
82MP0005385_cardiovascular_system_phenoty1.00889059
83MP0001346_abnormal_lacrimal_gland0.99981164
84MP0010630_abnormal_cardiac_muscle0.94864912
85MP0002080_prenatal_lethality0.94670045
86MP0002160_abnormal_reproductive_system0.93815150
87MP0005369_muscle_phenotype0.91937661
88MP0003705_abnormal_hypodermis_morpholog0.91340739
89MP0008004_abnormal_stomach_pH0.91087767
90MP0002132_abnormal_respiratory_system0.90625799
91MP0000350_abnormal_cell_proliferation0.90575878
92MP0000762_abnormal_tongue_morphology0.88994578
93MP0002971_abnormal_brown_adipose0.88377143
94MP0006138_congestive_heart_failure0.88187440
95MP0003191_abnormal_cellular_cholesterol0.85629963
96MP0003385_abnormal_body_wall0.84619327
97MP0008007_abnormal_cellular_replicative0.84450162
98MP0000467_abnormal_esophagus_morphology0.82816141
99MP0003868_abnormal_feces_composition0.81035719
100MP0003111_abnormal_nucleus_morphology0.79855624
101MP0008932_abnormal_embryonic_tissue0.79575984
102MP0003453_abnormal_keratinocyte_physiol0.79470784
103MP0005376_homeostasis/metabolism_phenot0.79274643
104MP0005647_abnormal_sex_gland0.77622787
105MP0000358_abnormal_cell_content/0.76054040
106MP0000681_abnormal_thyroid_gland0.75283445
107MP0005380_embryogenesis_phenotype0.74325540
108MP0001672_abnormal_embryogenesis/_devel0.74325540
109MP0004510_myositis0.73758836
110MP0002078_abnormal_glucose_homeostasis0.73118161
111MP0002653_abnormal_ependyma_morphology0.72516440
112MP0002332_abnormal_exercise_endurance0.72434750
113MP0003329_amyloid_beta_deposits0.72359859
114MP0002089_abnormal_postnatal_growth/wei0.72159374
115MP0003984_embryonic_growth_retardation0.71898502
116MP0005636_abnormal_mineral_homeostasis0.71182736
117MP0000013_abnormal_adipose_tissue0.70304634
118MP0004085_abnormal_heartbeat0.68685586
119MP0004264_abnormal_extraembryonic_tissu0.66858429
120MP0002127_abnormal_cardiovascular_syste0.66789807
121MP0004957_abnormal_blastocyst_morpholog0.66519475
122MP0005451_abnormal_body_composition0.66241146
123MP0000566_synostosis0.65670368
124MP0002088_abnormal_embryonic_growth/wei0.65529926
125MP0005621_abnormal_cell_physiology0.64674439
126MP0000598_abnormal_liver_morphology0.64598125
127MP0008438_abnormal_cutaneous_collagen0.64576527
128MP0003567_abnormal_fetal_cardiomyocyte0.64128611
129MP0005334_abnormal_fat_pad0.63933136
130MP0002970_abnormal_white_adipose0.63175992
131MP0001727_abnormal_embryo_implantation0.63115200
132MP0001881_abnormal_mammary_gland0.61580929
133MP0003656_abnormal_erythrocyte_physiolo0.61422126
134MP0005535_abnormal_body_temperature0.59904681
135MP0010030_abnormal_orbit_morphology0.59223653
136MP0009672_abnormal_birth_weight0.58737373
137MP0002108_abnormal_muscle_morphology0.58731693
138MP0002210_abnormal_sex_determination0.57686055
139MP0001145_abnormal_male_reproductive0.57600112
140MP0009379_abnormal_foot_pigmentation0.55367783
141MP0003878_abnormal_ear_physiology0.54810903
142MP0005377_hearing/vestibular/ear_phenot0.54810903
143MP0005084_abnormal_gallbladder_morpholo0.54053133
144MP0001929_abnormal_gametogenesis0.53995074
145MP0003693_abnormal_embryo_hatching0.53860544
146MP0005395_other_phenotype0.53426239
147MP0003698_abnormal_male_reproductive0.53114343

Predicted human phenotypes

RankGene SetZ-score
1Centrally nucleated skeletal muscle fibers (HP:0003687)4.95384885
2Hyperglycinuria (HP:0003108)4.49189632
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.40485178
4Muscle fiber inclusion bodies (HP:0100299)4.39420859
5Myopathic facies (HP:0002058)4.16537286
6Hyperammonemia (HP:0001987)4.16426807
7Abnormality of serine family amino acid metabolism (HP:0010894)4.14956574
8Abnormality of glycine metabolism (HP:0010895)4.14956574
9Hepatic necrosis (HP:0002605)4.14155192
10Ketosis (HP:0001946)4.09579937
11Myoglobinuria (HP:0002913)3.96972876
12Hyperglycinemia (HP:0002154)3.90637264
13Cerebral edema (HP:0002181)3.80419900
14Hepatocellular necrosis (HP:0001404)3.80372944
15Dicarboxylic aciduria (HP:0003215)3.77161826
16Abnormality of dicarboxylic acid metabolism (HP:0010995)3.77161826
17EMG: myopathic abnormalities (HP:0003458)3.74372512
18Nemaline bodies (HP:0003798)3.74000049
19Abnormality of fatty-acid metabolism (HP:0004359)3.71810381
20Ketoacidosis (HP:0001993)3.71403687
21Hyporeflexia of lower limbs (HP:0002600)3.70976228
22Rhabdomyolysis (HP:0003201)3.65595221
23Spinal rigidity (HP:0003306)3.64437342
24Abnormality of aromatic amino acid family metabolism (HP:0004338)3.59588611
25Acute encephalopathy (HP:0006846)3.52669638
26Scapular winging (HP:0003691)3.49054817
27Hypoglycemic coma (HP:0001325)3.47986590
28Intrahepatic cholestasis (HP:0001406)3.43792601
29Abnormality of skeletal muscle fiber size (HP:0012084)3.39239479
30Decreased activity of mitochondrial respiratory chain (HP:0008972)3.36644149
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.36644149
32Abnormal mitochondria in muscle tissue (HP:0008316)3.36385222
33Increased variability in muscle fiber diameter (HP:0003557)3.31317185
34Abnormality of monocarboxylic acid metabolism (HP:0010996)3.30220516
35Type 1 muscle fiber predominance (HP:0003803)3.29414457
36Increased muscle lipid content (HP:0009058)3.29318693
37Lethargy (HP:0001254)3.28384376
38Lactic acidosis (HP:0003128)3.26833586
39Acute necrotizing encephalopathy (HP:0006965)3.26393407
40Xanthomatosis (HP:0000991)3.24901207
41Hypobetalipoproteinemia (HP:0003563)3.24200737
42Achilles tendon contracture (HP:0001771)3.22555577
43Abnormality of serum amino acid levels (HP:0003112)3.11678324
44Deep venous thrombosis (HP:0002625)3.10281342
45Rimmed vacuoles (HP:0003805)3.08497209
46Abnormality of the Achilles tendon (HP:0005109)3.06235694
47Neck muscle weakness (HP:0000467)3.05892574
48Progressive external ophthalmoplegia (HP:0000590)3.05811664
49Increased CSF lactate (HP:0002490)3.03801409
50Increased connective tissue (HP:0009025)3.03540365
51Mitochondrial inheritance (HP:0001427)3.03421891
52Reduced antithrombin III activity (HP:0001976)3.02483623
53Delayed CNS myelination (HP:0002188)3.00579719
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.99509325
55Increased serum lactate (HP:0002151)2.95167957
56Distal lower limb muscle weakness (HP:0009053)2.94808111
57Increased serum pyruvate (HP:0003542)2.89260777
58Abnormality of glycolysis (HP:0004366)2.89260777
59Hypolipoproteinemia (HP:0010981)2.87515651
60Increased intramyocellular lipid droplets (HP:0012240)2.86675602
61Abnormality of the calf musculature (HP:0001430)2.84705284
62Ragged-red muscle fibers (HP:0003200)2.82134974
63Distal lower limb amyotrophy (HP:0008944)2.81816838
64Hyperlipoproteinemia (HP:0010980)2.81345811
65Hypoalphalipoproteinemia (HP:0003233)2.80608100
66Proximal tubulopathy (HP:0000114)2.78925448
67Back pain (HP:0003418)2.78731748
68Progressive muscle weakness (HP:0003323)2.77868762
69Abnormality of alanine metabolism (HP:0010916)2.75884977
70Hyperalaninemia (HP:0003348)2.75884977
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75884977
72Resting tremor (HP:0002322)2.74906692
73Right ventricular cardiomyopathy (HP:0011663)2.72038201
74Sudden death (HP:0001699)2.70596213
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70513598
76Bulbar palsy (HP:0001283)2.65852873
77Abnormality of methionine metabolism (HP:0010901)2.65478415
78Metabolic acidosis (HP:0001942)2.61875716
79Exercise-induced myalgia (HP:0003738)2.61599869
80Limb-girdle muscle atrophy (HP:0003797)2.61366783
81Abnormality of the shoulder girdle musculature (HP:0001435)2.60864292
82Exercise intolerance (HP:0003546)2.57657174
83Foot dorsiflexor weakness (HP:0009027)2.56932191
84Lipid accumulation in hepatocytes (HP:0006561)2.56688444
85Progressive macrocephaly (HP:0004481)2.55278572
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.54744523
87Abnormality of pyrimidine metabolism (HP:0004353)2.53190332
88Hyperacusis (HP:0010780)2.53047024
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50277096
90Difficulty climbing stairs (HP:0003551)2.48903432
91Exercise-induced muscle cramps (HP:0003710)2.48194277
92Gout (HP:0001997)2.48084666
93Generalized aminoaciduria (HP:0002909)2.47860496
94Respiratory failure (HP:0002878)2.47321807
95CNS demyelination (HP:0007305)2.45138213
96Palpitations (HP:0001962)2.43292109
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42888920
98Abnormality of sulfur amino acid metabolism (HP:0004339)2.42628330
99Vertebral compression fractures (HP:0002953)2.42479732
100Prolonged partial thromboplastin time (HP:0003645)2.41785574
101Ventricular tachycardia (HP:0004756)2.39922710
102Vomiting (HP:0002013)2.38767987
103Abnormality of the foot musculature (HP:0001436)2.36587409
104Generalized amyotrophy (HP:0003700)2.34718603
105Muscle hypertrophy of the lower extremities (HP:0008968)2.30179235
106Methylmalonic aciduria (HP:0012120)2.27863923
107Muscle fiber splitting (HP:0003555)2.20169141
108Multiple enchondromatosis (HP:0005701)2.17137952
109Premature rupture of membranes (HP:0001788)2.12088779
110Thoracic kyphosis (HP:0002942)2.09505838
111Diaphragmatic weakness (HP:0009113)2.09053399
112Distal arthrogryposis (HP:0005684)2.08402291
113Lipoatrophy (HP:0100578)2.08138905
114Nausea (HP:0002018)2.08116020
115Mildly elevated creatine phosphokinase (HP:0008180)2.06604196
116Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06181780
117Abnormality of the intrinsic pathway (HP:0010989)2.05872799
118Abnormality of nucleobase metabolism (HP:0010932)2.04355618
119Testicular atrophy (HP:0000029)2.04217565
120Muscle stiffness (HP:0003552)2.03379232
121Increased hepatocellular lipid droplets (HP:0006565)2.02921929
122Late onset (HP:0003584)2.02604429
123Self-mutilation (HP:0000742)2.01824040
124Trismus (HP:0000211)2.00583990
125Reticulocytopenia (HP:0001896)2.00102673
126Microvesicular hepatic steatosis (HP:0001414)1.99483388
127Increased purine levels (HP:0004368)1.99159516
128Hyperuricemia (HP:0002149)1.99159516
129Dilated cardiomyopathy (HP:0001644)1.97320467
130Elbow flexion contracture (HP:0002987)1.95379993
131Protrusio acetabuli (HP:0003179)1.93257132
132Abnormal gallbladder morphology (HP:0012437)1.92632967
133Reticulocytosis (HP:0001923)1.90970446
134Epidermoid cyst (HP:0200040)1.90250014
135Abnormal gallbladder physiology (HP:0012438)1.89407107
136Cholecystitis (HP:0001082)1.89407107
137Shoulder girdle muscle weakness (HP:0003547)1.88674567
138Hyperbilirubinemia (HP:0002904)1.86939063
139Abnormality of the thoracic spine (HP:0100711)1.86899985
140Complement deficiency (HP:0004431)1.84443114
141Emotional lability (HP:0000712)1.83724167
142Cholelithiasis (HP:0001081)1.83546466
143Hyperinsulinemic hypoglycemia (HP:0000825)1.83328853
144Calf muscle hypertrophy (HP:0008981)1.83123170
145Glycosuria (HP:0003076)1.82660795
146Abnormality of urine glucose concentration (HP:0011016)1.82660795
147Neoplasm of the adrenal gland (HP:0100631)1.82074288
148Opisthotonus (HP:0002179)1.81954081
149Leukodystrophy (HP:0002415)1.81646576
150Lower limb amyotrophy (HP:0007210)1.80958630
151Asymmetric septal hypertrophy (HP:0001670)1.80026486
152Round ear (HP:0100830)1.79671840
153Ulnar bowing (HP:0003031)1.79304818
154Axonal loss (HP:0003447)1.77336073
155Breech presentation (HP:0001623)1.70746220
156Insomnia (HP:0100785)1.70480602
157Calcaneovalgus deformity (HP:0001848)1.70303346
158Abnormality of the umbilical cord (HP:0010881)1.67429790
159Pelvic girdle muscle weakness (HP:0003749)1.67424234
160Respiratory insufficiency due to muscle weakness (HP:0002747)1.67285039
161Frequent falls (HP:0002359)1.66469687
162Distal upper limb amyotrophy (HP:0007149)1.66368440
163Upper limb amyotrophy (HP:0009129)1.66368440
164Easy fatigability (HP:0003388)1.65779045
165Malignant hyperthermia (HP:0002047)1.65085128
166Abnormality of the tricuspid valve (HP:0001702)1.62721145
167Abnormality of the gallbladder (HP:0005264)1.62611582
168Abnormality of the columella (HP:0009929)1.58043486
169Sparse lateral eyebrow (HP:0005338)1.57606791
170Muscular dystrophy (HP:0003560)1.57446007
171Generalized muscle weakness (HP:0003324)1.57295353
172Proximal amyotrophy (HP:0007126)1.55058352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.95280133
2BUB13.44602191
3PDK43.33472163
4PDK33.33472163
5SMG12.87483870
6STK162.87075064
7EEF2K2.49403306
8NEK12.46039181
9IRAK32.38247784
10ARAF2.36685248
11ZAK2.34641724
12PINK12.31851111
13LMTK22.22614418
14PRPF4B1.97089327
15TLK11.97042320
16PKN21.90931544
17PHKG21.86490819
18PHKG11.86490819
19PDK21.86408362
20WEE11.85861310
21VRK21.81369291
22ERN11.78851112
23TRIB31.74511970
24NME21.71915319
25MARK11.71523953
26LATS21.70118084
27CDK121.68459044
28TTN1.68451615
29OBSCN1.59932599
30IRAK21.52201799
31PLK41.50524789
32TTK1.49336339
33MARK31.44632708
34EPHA21.44592910
35STK38L1.43166053
36MST1R1.41089440
37EIF2AK11.35595096
38TESK21.34092755
39MAP3K111.29431905
40PBK1.27421764
41PNCK1.27382320
42NME11.23401343
43DYRK31.21387503
44WNK41.19730820
45TESK11.19098992
46KDR1.16557992
47EPHA41.14631815
48MAP3K11.13902860
49SIK11.12472354
50MYLK1.09957812
51MAPKAPK31.02931504
52KSR21.01523581
53AURKA1.01217176
54RPS6KB20.99541975
55ICK0.96771605
56ABL20.96537216
57CDK80.94380472
58CCNB10.94075133
59RIPK10.92510947
60MAP3K100.91064271
61CSNK1A1L0.90777038
62IRAK10.89924025
63CSNK1G30.88791180
64SRPK10.87087853
65MAP2K30.85845905
66DAPK30.85711019
67MOS0.85521564
68BRAF0.84087247
69MAP3K130.83351212
70LATS10.78255235
71CAMK2G0.76507403
72FLT30.75906989
73MAP3K90.75285470
74CAMK2D0.75059108
75MUSK0.74828490
76CDC70.73290754
77NEK20.71882767
78CDK140.69790460
79MAP2K40.69292103
80EIF2AK30.67849280
81VRK10.67760442
82PRKD30.66964667
83PLK10.65854077
84RAF10.65435797
85SCYL20.64953003
86PDGFRA0.64799508
87LIMK10.64646993
88STK390.63637967
89EPHB10.62688857
90MAPK120.62399358
91PDPK10.61753859
92CDK70.61743084
93MAP2K70.58523971
94INSRR0.58512819
95TIE10.58033686
96FGFR40.55578649
97AKT20.55305294
98STK380.54685900
99TAOK20.54658958
100LRRK20.53955564
101DYRK20.53118962
102PTK20.52716509
103PRKCI0.52197414
104CHEK20.50418132
105MAP3K80.50275470
106MET0.49885984
107PRKG20.49662302
108DAPK10.49342211
109PAK60.49241460
110MAP3K50.48227485
111MAP3K30.47359506
112BRSK10.46514761
113PAK30.45581533
114CDK150.44225794
115PAK40.43818390
116CDK11A0.43726356
117CDK90.41669975
118CSNK1G10.41669655
119AURKB0.41233284
120ILK0.41086189
121CSNK1E0.40451677
122RPS6KB10.40041776
123PAK10.39999264
124PIK3CG0.39231870
125CDK180.39191600
126CAMK2B0.36845834
127CDC42BPA0.36719168
128ROCK10.36389092
129CSNK2A20.33376508
130CDK40.33257343
131ATR0.30289959
132PAK20.29623542
133MAPK110.29264194
134CSNK2A10.28667756
135MAP2K60.27606222
136FER0.27392417
137PRKAA10.27186611
138MAP3K60.26986129
139MTOR0.26634211
140PRKACG0.26257123
141MAP2K20.24650379
142PRKACB0.24377059
143PIM20.24272311

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.10082833
2Propanoate metabolism_Homo sapiens_hsa006403.02618972
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.00972113
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91635494
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82207402
6Fatty acid degradation_Homo sapiens_hsa000712.75870037
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51875342
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.29568136
9Carbon metabolism_Homo sapiens_hsa012002.28435649
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24210929
11Pyruvate metabolism_Homo sapiens_hsa006202.15425210
12Fatty acid metabolism_Homo sapiens_hsa012122.13186230
13Butanoate metabolism_Homo sapiens_hsa006502.01298669
14Biosynthesis of amino acids_Homo sapiens_hsa012301.97843336
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90926415
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88419989
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88265327
18Oxidative phosphorylation_Homo sapiens_hsa001901.86330069
19Nitrogen metabolism_Homo sapiens_hsa009101.85742736
20Tryptophan metabolism_Homo sapiens_hsa003801.85542333
21Arginine biosynthesis_Homo sapiens_hsa002201.83088525
22Parkinsons disease_Homo sapiens_hsa050121.75119597
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.70495929
24Peroxisome_Homo sapiens_hsa041461.69407914
25Ribosome_Homo sapiens_hsa030101.69258908
26beta-Alanine metabolism_Homo sapiens_hsa004101.64671455
27PPAR signaling pathway_Homo sapiens_hsa033201.56022555
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55370642
29One carbon pool by folate_Homo sapiens_hsa006701.54397141
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50177754
31Fatty acid elongation_Homo sapiens_hsa000621.48503002
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42728674
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38549274
34Selenocompound metabolism_Homo sapiens_hsa004501.37687772
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36463420
36Phenylalanine metabolism_Homo sapiens_hsa003601.34393080
37Huntingtons disease_Homo sapiens_hsa050161.29610742
38Folate biosynthesis_Homo sapiens_hsa007901.28691044
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.26630643
40DNA replication_Homo sapiens_hsa030301.25053131
41Cardiac muscle contraction_Homo sapiens_hsa042601.24533320
42Arginine and proline metabolism_Homo sapiens_hsa003301.23593184
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19846801
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19659342
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19101012
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18678688
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.17460908
48Pentose phosphate pathway_Homo sapiens_hsa000301.17359257
49Proteasome_Homo sapiens_hsa030501.16800172
50Sulfur relay system_Homo sapiens_hsa041221.15006386
51Tyrosine metabolism_Homo sapiens_hsa003501.14935589
52Chemical carcinogenesis_Homo sapiens_hsa052041.14680485
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14190954
54Glutathione metabolism_Homo sapiens_hsa004801.11618917
55Alzheimers disease_Homo sapiens_hsa050101.11106156
56Other glycan degradation_Homo sapiens_hsa005111.10816546
57Starch and sucrose metabolism_Homo sapiens_hsa005001.04848568
58Insulin signaling pathway_Homo sapiens_hsa049101.04151590
59Fat digestion and absorption_Homo sapiens_hsa049751.02742549
60Bladder cancer_Homo sapiens_hsa052191.02223889
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.97524218
62Pyrimidine metabolism_Homo sapiens_hsa002400.97312519
63Mismatch repair_Homo sapiens_hsa034300.95200877
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93567776
65Prion diseases_Homo sapiens_hsa050200.91191816
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90981277
67Histidine metabolism_Homo sapiens_hsa003400.90086284
68Retinol metabolism_Homo sapiens_hsa008300.89509806
69Complement and coagulation cascades_Homo sapiens_hsa046100.88701028
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88436671
71N-Glycan biosynthesis_Homo sapiens_hsa005100.87919464
72Dilated cardiomyopathy_Homo sapiens_hsa054140.87520214
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86482765
74Fatty acid biosynthesis_Homo sapiens_hsa000610.84275449
75Metabolic pathways_Homo sapiens_hsa011000.84038617
76Thyroid cancer_Homo sapiens_hsa052160.82148025
77RNA polymerase_Homo sapiens_hsa030200.80541590
78Vitamin B6 metabolism_Homo sapiens_hsa007500.79176626
79Glycerolipid metabolism_Homo sapiens_hsa005610.72043630
80Fructose and mannose metabolism_Homo sapiens_hsa000510.71604625
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70944368
82Sulfur metabolism_Homo sapiens_hsa009200.67667894
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67345971
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66929780
85Bile secretion_Homo sapiens_hsa049760.66132675
86Galactose metabolism_Homo sapiens_hsa000520.65908843
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65189384
88Caffeine metabolism_Homo sapiens_hsa002320.64027876
89Non-small cell lung cancer_Homo sapiens_hsa052230.62470720
90Endometrial cancer_Homo sapiens_hsa052130.62177087
91Lysine degradation_Homo sapiens_hsa003100.61081188
92Vibrio cholerae infection_Homo sapiens_hsa051100.60158961
93Nucleotide excision repair_Homo sapiens_hsa034200.58331048
94Chronic myeloid leukemia_Homo sapiens_hsa052200.55677189
95Cell cycle_Homo sapiens_hsa041100.52722952
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50923356
97Apoptosis_Homo sapiens_hsa042100.49814546
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49401555
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.49243304
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48241412
101Acute myeloid leukemia_Homo sapiens_hsa052210.47946595
102Spliceosome_Homo sapiens_hsa030400.46510778
103Vitamin digestion and absorption_Homo sapiens_hsa049770.46449752
104mRNA surveillance pathway_Homo sapiens_hsa030150.44470278
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44161584
106Purine metabolism_Homo sapiens_hsa002300.43091691
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41708179
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40738764
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39229344
110Glioma_Homo sapiens_hsa052140.38391776
111Systemic lupus erythematosus_Homo sapiens_hsa053220.37293166
112Homologous recombination_Homo sapiens_hsa034400.36551215
113Linoleic acid metabolism_Homo sapiens_hsa005910.36472335
114Base excision repair_Homo sapiens_hsa034100.35866824
115RNA transport_Homo sapiens_hsa030130.35479704
116Glucagon signaling pathway_Homo sapiens_hsa049220.35259610
117Insulin resistance_Homo sapiens_hsa049310.34508998
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34436561
119mTOR signaling pathway_Homo sapiens_hsa041500.33067281
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31154836
121Pancreatic cancer_Homo sapiens_hsa052120.30065111
122Gap junction_Homo sapiens_hsa045400.28748443
123Focal adhesion_Homo sapiens_hsa045100.27381447
124Fanconi anemia pathway_Homo sapiens_hsa034600.26630944
125ABC transporters_Homo sapiens_hsa020100.26150897
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25913706
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25732190
128Steroid biosynthesis_Homo sapiens_hsa001000.20864668
129AMPK signaling pathway_Homo sapiens_hsa041520.19741426
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18794146
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.17546931
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17423002
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.16517074
134Arachidonic acid metabolism_Homo sapiens_hsa005900.15743847
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.14378330

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