POLE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.56876103
2DNA strand elongation (GO:0022616)5.29333217
3* DNA replication initiation (GO:0006270)5.23564765
4DNA unwinding involved in DNA replication (GO:0006268)5.21888028
5* telomere maintenance via semi-conservative replication (GO:0032201)5.20043846
6establishment of integrated proviral latency (GO:0075713)4.82481649
7DNA replication checkpoint (GO:0000076)4.76138180
8* telomere maintenance via recombination (GO:0000722)4.67745101
9ribosomal small subunit assembly (GO:0000028)4.64615621
10* mitotic recombination (GO:0006312)4.52393666
11protein localization to kinetochore (GO:0034501)4.46922776
12CENP-A containing nucleosome assembly (GO:0034080)4.35181322
13proteasome assembly (GO:0043248)4.29052643
14chromatin remodeling at centromere (GO:0031055)4.26296975
15nucleobase biosynthetic process (GO:0046112)4.25372165
16mitotic metaphase plate congression (GO:0007080)4.24385895
17* telomere maintenance via telomere lengthening (GO:0010833)4.15833830
18regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.08351285
19kinetochore organization (GO:0051383)4.00244022
20DNA replication-dependent nucleosome assembly (GO:0006335)3.99479685
21DNA replication-dependent nucleosome organization (GO:0034723)3.99479685
22DNA replication-independent nucleosome organization (GO:0034724)3.98720888
23DNA replication-independent nucleosome assembly (GO:0006336)3.98720888
24IMP biosynthetic process (GO:0006188)3.98566442
25mitotic nuclear envelope disassembly (GO:0007077)3.95232125
26nuclear pore organization (GO:0006999)3.92844727
27* nucleotide-excision repair, DNA gap filling (GO:0006297)3.91347489
28purine nucleobase biosynthetic process (GO:0009113)3.88397936
29maturation of SSU-rRNA (GO:0030490)3.86734716
30protein localization to chromosome, centromeric region (GO:0071459)3.86726641
31DNA ligation (GO:0006266)3.82884353
32nuclear pore complex assembly (GO:0051292)3.79506776
33DNA deamination (GO:0045006)3.78921715
34formation of translation preinitiation complex (GO:0001731)3.77602509
35DNA double-strand break processing (GO:0000729)3.77478423
36metaphase plate congression (GO:0051310)3.74657099
37establishment of viral latency (GO:0019043)3.70204111
38folic acid-containing compound biosynthetic process (GO:0009396)3.70120181
39attachment of spindle microtubules to kinetochore (GO:0008608)3.68564970
40replication fork processing (GO:0031297)3.64447201
41nuclear envelope disassembly (GO:0051081)3.64086880
42membrane disassembly (GO:0030397)3.64086880
43non-recombinational repair (GO:0000726)3.63770359
44double-strand break repair via nonhomologous end joining (GO:0006303)3.63770359
45viral transcription (GO:0019083)3.60116035
46mitotic chromosome condensation (GO:0007076)3.59227112
47translational termination (GO:0006415)3.57371247
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55240312
49histone exchange (GO:0043486)3.55064746
50kinetochore assembly (GO:0051382)3.53279420
51IMP metabolic process (GO:0046040)3.50741800
52mitotic sister chromatid segregation (GO:0000070)3.48706920
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47068273
54ribosome biogenesis (GO:0042254)3.44753949
55regulation of centriole replication (GO:0046599)3.44135137
56mitotic spindle checkpoint (GO:0071174)3.42968676
57establishment of chromosome localization (GO:0051303)3.40953326
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39996968
59ribosome assembly (GO:0042255)3.39456435
60ribosomal large subunit biogenesis (GO:0042273)3.39407232
61DNA duplex unwinding (GO:0032508)3.38635927
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.37663652
63DNA geometric change (GO:0032392)3.36967973
64postreplication repair (GO:0006301)3.36155292
65ribonucleoprotein complex biogenesis (GO:0022613)3.35179590
66sister chromatid segregation (GO:0000819)3.32989816
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.30450110
68regulation of DNA endoreduplication (GO:0032875)3.30193164
69regulation of mitochondrial translation (GO:0070129)3.30059479
70regulation of spindle organization (GO:0090224)3.29756310
71translational elongation (GO:0006414)3.29735659
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.29014998
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29014998
74DNA catabolic process, exonucleolytic (GO:0000738)3.27944203
75* telomere maintenance (GO:0000723)3.27811038
76establishment of protein localization to mitochondrial membrane (GO:0090151)3.26750472
77* telomere organization (GO:0032200)3.26549626
78ribosomal small subunit biogenesis (GO:0042274)3.25532885
79regulation of nuclear cell cycle DNA replication (GO:0033262)3.25426668
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23416250
81regulation of mitotic sister chromatid separation (GO:0010965)3.22111247
82regulation of mitotic sister chromatid segregation (GO:0033047)3.22111247
83regulation of sister chromatid segregation (GO:0033045)3.22111247
84translational initiation (GO:0006413)3.21807309
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21647774
86negative regulation of ligase activity (GO:0051352)3.21647774
87chromosome segregation (GO:0007059)3.17277680
88chromatin assembly or disassembly (GO:0006333)3.16744985
89pore complex assembly (GO:0046931)3.16397951
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15943283
91protein K6-linked ubiquitination (GO:0085020)3.15139230
92translesion synthesis (GO:0019985)3.14823840
93synapsis (GO:0007129)3.14272436
94pseudouridine synthesis (GO:0001522)3.12958281
95DNA topological change (GO:0006265)3.12730672
96regulation of centrosome cycle (GO:0046605)3.11939380
97rRNA processing (GO:0006364)3.11007128
98mismatch repair (GO:0006298)3.10687219
99* cell cycle G1/S phase transition (GO:0044843)3.07516504
100* G1/S transition of mitotic cell cycle (GO:0000082)3.07516504
101* transcription-coupled nucleotide-excision repair (GO:0006283)3.07415170
102mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06667551
103meiotic chromosome segregation (GO:0045132)3.06464378
104SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05569530
105regulation of double-strand break repair via homologous recombination (GO:0010569)3.04795362
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02749146
107mitotic G2/M transition checkpoint (GO:0044818)3.02688502
108negative regulation of chromosome segregation (GO:0051985)3.02562122
109negative regulation of mitotic sister chromatid separation (GO:2000816)3.01543479
110negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01543479
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01543479
112negative regulation of sister chromatid segregation (GO:0033046)3.01543479
113rRNA metabolic process (GO:0016072)3.01528695
114spindle checkpoint (GO:0031577)3.01417533
115DNA strand renaturation (GO:0000733)3.01002942
116regulation of helicase activity (GO:0051095)3.00113425
117spliceosomal snRNP assembly (GO:0000387)3.00055338
118cotranslational protein targeting to membrane (GO:0006613)2.96049557
119protein targeting to ER (GO:0045047)2.95045141
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94531392
121spindle assembly checkpoint (GO:0071173)2.94433742
122regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94404976
123ATP-dependent chromatin remodeling (GO:0043044)2.93245712
124regulation of chromosome segregation (GO:0051983)2.90754162
125positive regulation of chromosome segregation (GO:0051984)2.90678864
126DNA conformation change (GO:0071103)2.90134179
127* DNA replication (GO:0006260)2.89256762
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89148783
129negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88822472
130mitotic spindle assembly checkpoint (GO:0007094)2.88444739
131mitotic sister chromatid cohesion (GO:0007064)2.87921496
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87876434
133base-excision repair (GO:0006284)2.87591237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.32196794
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.13540238
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00025887
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63486386
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26375785
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99016405
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86760000
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73967362
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.73439676
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70237149
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.56028711
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.50767765
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47847786
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43966718
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32945214
16* AR_21909140_ChIP-Seq_LNCAP_Human2.31645576
17XRN2_22483619_ChIP-Seq_HELA_Human2.24041998
18* E2F1_21310950_ChIP-Seq_MCF-7_Human2.20831026
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18930203
20VDR_23849224_ChIP-Seq_CD4+_Human2.15861742
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.07868642
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06065057
23E2F7_22180533_ChIP-Seq_HELA_Human10.2412594
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96162349
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92600000
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89368719
27FOXP3_21729870_ChIP-Seq_TREG_Human1.88994236
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88956279
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84475496
30DCP1A_22483619_ChIP-Seq_HELA_Human1.83166183
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79469173
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77635566
33GABP_19822575_ChIP-Seq_HepG2_Human1.73877432
34TTF2_22483619_ChIP-Seq_HELA_Human1.73673417
35MYC_22102868_ChIP-Seq_BL_Human1.71981050
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71916594
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68120631
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63741189
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63487649
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63093253
41ELK1_19687146_ChIP-ChIP_HELA_Human1.61096343
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59487723
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57420494
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57283412
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56287311
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55961589
47CIITA_25753668_ChIP-Seq_RAJI_Human1.54236694
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52312629
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49670402
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46386295
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44097583
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35520571
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35149546
54KDM5A_27292631_Chip-Seq_BREAST_Human1.33594814
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33375805
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.29885018
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29813296
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28278201
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26649120
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.25094938
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21288904
62* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20761693
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.20342644
64IRF1_19129219_ChIP-ChIP_H3396_Human1.18547655
65EWS_26573619_Chip-Seq_HEK293_Human1.17468521
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15052762
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.13995737
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13663394
69VDR_21846776_ChIP-Seq_THP-1_Human1.13442688
70* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13249795
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10751398
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09886311
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08759032
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08233276
75TFEB_21752829_ChIP-Seq_HELA_Human1.08189424
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07405929
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07218313
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.04264232
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03732545
80SPI1_23547873_ChIP-Seq_NB4_Human1.03388569
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02973616
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01543225
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01094861
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.00865196
85MYC_18940864_ChIP-ChIP_HL60_Human1.00468053
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00324804
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98445965
88FUS_26573619_Chip-Seq_HEK293_Human0.95110921
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92708341
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.92330322
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91448605
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89747077
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89197640
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89080002
95ZNF274_21170338_ChIP-Seq_K562_Hela0.88499265
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86500981
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85702830
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84774670
99* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82979757
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82212420
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79944758
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79843656
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79227274
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75316100
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.73105424
106* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72128421
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.72053262
108VDR_22108803_ChIP-Seq_LS180_Human0.71644939
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.71141331
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.69952312
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.69791341
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.69709424
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69628968
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69248090
115MYB_26560356_Chip-Seq_TH1_Human0.68605823
116IGF1R_20145208_ChIP-Seq_DFB_Human0.67440162
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.65242574
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.60411176
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.60102818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.32498860
2MP0010094_abnormal_chromosome_stability5.03535222
3MP0003111_abnormal_nucleus_morphology4.65624002
4MP0004957_abnormal_blastocyst_morpholog4.42345584
5MP0008057_abnormal_DNA_replication4.16929339
6MP0003077_abnormal_cell_cycle4.10442165
7MP0008058_abnormal_DNA_repair3.37948834
8MP0002396_abnormal_hematopoietic_system3.25402436
9MP0008007_abnormal_cellular_replicative2.90950751
10MP0008932_abnormal_embryonic_tissue2.61295118
11MP0009697_abnormal_copulation2.44889583
12MP0010352_gastrointestinal_tract_polyps2.34193152
13MP0003123_paternal_imprinting2.26761026
14MP0000350_abnormal_cell_proliferation2.23891580
15MP0001730_embryonic_growth_arrest2.22510423
16MP0000490_abnormal_crypts_of1.99276550
17MP0010307_abnormal_tumor_latency1.96357008
18MP0008877_abnormal_DNA_methylation1.85924849
19MP0003786_premature_aging1.81134642
20MP0004808_abnormal_hematopoietic_stem1.76184743
21MP0001697_abnormal_embryo_size1.66290819
22MP0005380_embryogenesis_phenotype1.65833857
23MP0001672_abnormal_embryogenesis/_devel1.65833857
24MP0003941_abnormal_skin_development1.58206364
25MP0002019_abnormal_tumor_incidence1.57828306
26MP0006054_spinal_hemorrhage1.57540217
27MP0006035_abnormal_mitochondrial_morpho1.56025725
28MP0002080_prenatal_lethality1.52568934
29MP0000313_abnormal_cell_death1.51850547
30MP0001545_abnormal_hematopoietic_system1.51097380
31MP0005397_hematopoietic_system_phenotyp1.51097380
32MP0003984_embryonic_growth_retardation1.49007275
33MP0002088_abnormal_embryonic_growth/wei1.45153936
34MP0003763_abnormal_thymus_physiology1.44570243
35MP0002085_abnormal_embryonic_tissue1.39882088
36MP0009333_abnormal_splenocyte_physiolog1.35697410
37MP0002086_abnormal_extraembryonic_tissu1.34881893
38MP0008789_abnormal_olfactory_epithelium1.33664006
39MP0003718_maternal_effect1.33627745
40MP0001529_abnormal_vocalization1.32982790
41MP0002398_abnormal_bone_marrow1.30142925
42MP0000703_abnormal_thymus_morphology1.29061299
43MP0006036_abnormal_mitochondrial_physio1.29016204
44MP0002084_abnormal_developmental_patter1.28436731
45MP0004197_abnormal_fetal_growth/weight/1.25595555
46MP0003121_genomic_imprinting1.25379007
47MP0003567_abnormal_fetal_cardiomyocyte1.24418247
48MP0003136_yellow_coat_color1.22432443
49MP0002722_abnormal_immune_system1.21050691
50MP0006072_abnormal_retinal_apoptosis1.16714295
51MP0000689_abnormal_spleen_morphology1.16439099
52MP0003806_abnormal_nucleotide_metabolis1.11578493
53MP0002210_abnormal_sex_determination1.07579914
54MP0005076_abnormal_cell_differentiation1.07014733
55MP0010030_abnormal_orbit_morphology1.05826913
56MP0001293_anophthalmia1.05446210
57MP0002429_abnormal_blood_cell1.01467379
58MP0002233_abnormal_nose_morphology1.00336254
59MP0002697_abnormal_eye_size0.97721921
60MP0000858_altered_metastatic_potential0.95437586
61MP0001145_abnormal_male_reproductive0.94431407
62MP0003186_abnormal_redox_activity0.93364417
63MP0008995_early_reproductive_senescence0.92880800
64MP0001286_abnormal_eye_development0.92796068
65MP0005499_abnormal_olfactory_system0.92428402
66MP0005394_taste/olfaction_phenotype0.92428402
67MP0000465_gastrointestinal_hemorrhage0.90676988
68MP0003890_abnormal_embryonic-extraembry0.90094456
69MP0003315_abnormal_perineum_morphology0.88525979
70MP0000716_abnormal_immune_system0.87873752
71MP0003698_abnormal_male_reproductive0.86529143
72MP0002102_abnormal_ear_morphology0.85231639
73MP0000372_irregular_coat_pigmentation0.84905096
74MP0001764_abnormal_homeostasis0.83951496
75MP0001929_abnormal_gametogenesis0.82931579
76MP0002095_abnormal_skin_pigmentation0.82918431
77MP0000653_abnormal_sex_gland0.82397685
78MP0006292_abnormal_olfactory_placode0.82391347
79MP0002160_abnormal_reproductive_system0.82379987
80MP0000358_abnormal_cell_content/0.82056274
81MP0001853_heart_inflammation0.81898004
82MP0001119_abnormal_female_reproductive0.81778878
83MP0001346_abnormal_lacrimal_gland0.80729948
84MP0000647_abnormal_sebaceous_gland0.80093163
85MP0009672_abnormal_birth_weight0.79226039
86MP0005023_abnormal_wound_healing0.78801974
87MP0005384_cellular_phenotype0.78659177
88MP0004147_increased_porphyrin_level0.76307365
89MP0005395_other_phenotype0.75865256
90MP0005174_abnormal_tail_pigmentation0.75279013
91MP0009053_abnormal_anal_canal0.74699613
92MP0003656_abnormal_erythrocyte_physiolo0.74579338
93MP0005389_reproductive_system_phenotype0.72907920
94MP0005621_abnormal_cell_physiology0.72861323
95MP0005075_abnormal_melanosome_morpholog0.72609418
96MP0001800_abnormal_humoral_immune0.72336328
97MP0002234_abnormal_pharynx_morphology0.71767086
98MP0002420_abnormal_adaptive_immunity0.70698751
99MP0003566_abnormal_cell_adhesion0.70324566
100MP0005408_hypopigmentation0.69452999
101MP0009278_abnormal_bone_marrow0.69190907
102MP0003646_muscle_fatigue0.69106375
103MP0002405_respiratory_system_inflammati0.69029714
104MP0001819_abnormal_immune_cell0.68772038
105MP0002111_abnormal_tail_morphology0.68473068
106MP0001835_abnormal_antigen_presentation0.68304013
107MP0002452_abnormal_antigen_presenting0.66696941
108MP0000477_abnormal_intestine_morphology0.65872659
109MP0001915_intracranial_hemorrhage0.65542346
110MP0002006_tumorigenesis0.65118303
111MP0002161_abnormal_fertility/fecundity0.64894712
112MP0003755_abnormal_palate_morphology0.64707379
113MP0003699_abnormal_female_reproductive0.64636561
114MP0003950_abnormal_plasma_membrane0.64195849
115MP0005671_abnormal_response_to0.63558678
116MP0000428_abnormal_craniofacial_morphol0.63350809
117MP0002132_abnormal_respiratory_system0.62855329
118MP0003937_abnormal_limbs/digits/tail_de0.62693317
119MP0003119_abnormal_digestive_system0.62647855
120MP0005171_absent_coat_pigmentation0.62467982
121MP0002736_abnormal_nociception_after0.61803520
122MP0002282_abnormal_trachea_morphology0.61592751
123MP0002166_altered_tumor_susceptibility0.61585785
124MP0009703_decreased_birth_body0.61272571
125MP0005253_abnormal_eye_physiology0.61088863
126MP0003861_abnormal_nervous_system0.59671535
127MP0002837_dystrophic_cardiac_calcinosis0.59613065
128MP0005391_vision/eye_phenotype0.59285761
129MP0002751_abnormal_autonomic_nervous0.59106669
130MP0001243_abnormal_dermal_layer0.58842049
131MP0009379_abnormal_foot_pigmentation0.58029135
132MP0000049_abnormal_middle_ear0.57422514
133MP0003221_abnormal_cardiomyocyte_apopto0.56346067
134MP0003936_abnormal_reproductive_system0.56120522
135MP0000537_abnormal_urethra_morphology0.55847212
136MP0003448_altered_tumor_morphology0.55562438
137MP0000631_abnormal_neuroendocrine_gland0.54792641
138MP0001661_extended_life_span0.54650458
139MP0002075_abnormal_coat/hair_pigmentati0.54359118
140MP0000566_synostosis0.53712404
141MP0002938_white_spotting0.52623267
142MP0001919_abnormal_reproductive_system0.52230643
143MP0002163_abnormal_gland_morphology0.51046843

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.61102564
2Reticulocytopenia (HP:0001896)4.60414214
3Chromsome breakage (HP:0040012)4.42635326
4Colon cancer (HP:0003003)4.28379835
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.15673267
6Abnormality of cells of the erythroid lineage (HP:0012130)4.02801961
7Abnormal number of erythroid precursors (HP:0012131)3.96521659
8Breast hypoplasia (HP:0003187)3.83324764
9Oral leukoplakia (HP:0002745)3.79613173
10Abnormality of chromosome stability (HP:0003220)3.56571635
11Abnormality of the preputium (HP:0100587)3.48391741
12Aplastic anemia (HP:0001915)3.44117977
13Patellar aplasia (HP:0006443)3.40288903
14Medulloblastoma (HP:0002885)3.29887730
15Meckel diverticulum (HP:0002245)3.28918805
16Selective tooth agenesis (HP:0001592)3.24742537
17Acute necrotizing encephalopathy (HP:0006965)3.19227206
18Increased hepatocellular lipid droplets (HP:0006565)3.17721339
19Aplasia/Hypoplasia of the patella (HP:0006498)3.16583900
20Abnormality of the ileum (HP:0001549)3.11598102
21Acute encephalopathy (HP:0006846)3.07905893
22Myelodysplasia (HP:0002863)3.00486899
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.94364558
24Abnormal mitochondria in muscle tissue (HP:0008316)2.90310184
25Abnormality of the anterior horn cell (HP:0006802)2.88150502
26Degeneration of anterior horn cells (HP:0002398)2.88150502
27Lipid accumulation in hepatocytes (HP:0006561)2.86581672
28Absent thumb (HP:0009777)2.85119384
29Increased CSF lactate (HP:0002490)2.80367707
30Agnosia (HP:0010524)2.80145228
31Small intestinal stenosis (HP:0012848)2.78668282
32Duodenal stenosis (HP:0100867)2.78668282
33Macrocytic anemia (HP:0001972)2.77326120
34Mitochondrial inheritance (HP:0001427)2.75184654
35Pallor (HP:0000980)2.72425397
36Carpal bone hypoplasia (HP:0001498)2.70896414
37Hepatocellular necrosis (HP:0001404)2.68061711
38Rough bone trabeculation (HP:0100670)2.66257199
39Premature graying of hair (HP:0002216)2.57902371
40Ependymoma (HP:0002888)2.56392968
41Microretrognathia (HP:0000308)2.55351504
42Bone marrow hypocellularity (HP:0005528)2.55215125
43Thrombocytosis (HP:0001894)2.53938617
44Increased serum pyruvate (HP:0003542)2.53341343
4511 pairs of ribs (HP:0000878)2.51828295
46Progressive macrocephaly (HP:0004481)2.51457479
47Squamous cell carcinoma (HP:0002860)2.48620140
48Microvesicular hepatic steatosis (HP:0001414)2.47877801
49Basal cell carcinoma (HP:0002671)2.47178314
50Abnormal number of incisors (HP:0011064)2.46875478
51Cerebral edema (HP:0002181)2.43482960
52Abnormal lung lobation (HP:0002101)2.43447156
53Ectopic kidney (HP:0000086)2.42134801
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39269774
55Absent radius (HP:0003974)2.39146883
56Duplicated collecting system (HP:0000081)2.39136956
57Neoplasm of the pancreas (HP:0002894)2.37806074
58Rhabdomyosarcoma (HP:0002859)2.34497586
59Abnormality of glycolysis (HP:0004366)2.33363662
60Hepatic necrosis (HP:0002605)2.32317324
61IgM deficiency (HP:0002850)2.29165549
62Impulsivity (HP:0100710)2.28339467
63Increased serum lactate (HP:0002151)2.26573334
64Sloping forehead (HP:0000340)2.24245267
65Abnormality of the duodenum (HP:0002246)2.20743925
66Absent forearm bone (HP:0003953)2.19840971
67Aplasia involving forearm bones (HP:0009822)2.19840971
68Lymphoma (HP:0002665)2.17896304
69Abnormality of DNA repair (HP:0003254)2.17340903
70Abnormality of the heme biosynthetic pathway (HP:0010472)2.17216758
71Slender long bone (HP:0003100)2.16184514
72Tracheoesophageal fistula (HP:0002575)2.16177184
73Cellular immunodeficiency (HP:0005374)2.15624059
74Renal Fanconi syndrome (HP:0001994)2.12321348
75Atresia of the external auditory canal (HP:0000413)2.11336165
76Abnormality of the carotid arteries (HP:0005344)2.10224132
77Abnormality of the renal collecting system (HP:0004742)2.09451818
78Pancytopenia (HP:0001876)2.08333795
79High pitched voice (HP:0001620)2.07741144
80Neoplasm of the colon (HP:0100273)2.07048565
81Clubbing of toes (HP:0100760)2.06938736
82Triphalangeal thumb (HP:0001199)2.06905948
83Increased nuchal translucency (HP:0010880)2.05115841
84Hyperglycinemia (HP:0002154)2.04581466
85Horseshoe kidney (HP:0000085)2.04362855
86Abnormality of reticulocytes (HP:0004312)2.00250317
87Cafe-au-lait spot (HP:0000957)1.99261681
88Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99040111
89Cerebral hypomyelination (HP:0006808)1.98316217
90Nephroblastoma (Wilms tumor) (HP:0002667)1.96598487
91Short thumb (HP:0009778)1.93521384
92Petechiae (HP:0000967)1.93483834
93Abnormality of the labia minora (HP:0012880)1.93478442
94Supernumerary spleens (HP:0009799)1.93197221
95Hypoplastic pelvis (HP:0008839)1.92135003
96Abnormality of methionine metabolism (HP:0010901)1.90519968
97Abnormality of pyrimidine metabolism (HP:0004353)1.89640384
98Lactic acidosis (HP:0003128)1.89464039
99Abnormal trabecular bone morphology (HP:0100671)1.89062594
100Type I transferrin isoform profile (HP:0003642)1.87773869
101Increased intramyocellular lipid droplets (HP:0012240)1.87545336
102Prominent nose (HP:0000448)1.84053232
103Choanal atresia (HP:0000453)1.83821243
104Amaurosis fugax (HP:0100576)1.83684452
105Trismus (HP:0000211)1.82281303
106Abnormality of cochlea (HP:0000375)1.81817934
107Volvulus (HP:0002580)1.81458879
108Embryonal renal neoplasm (HP:0011794)1.80990762
109Short 4th metacarpal (HP:0010044)1.80960459
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80960459
111Abnormality of the astrocytes (HP:0100707)1.79366478
112Astrocytoma (HP:0009592)1.79366478
113Arteriovenous malformation (HP:0100026)1.78466333
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78402248
115Cleft eyelid (HP:0000625)1.78223009
116Acute myeloid leukemia (HP:0004808)1.77909739
117Leukodystrophy (HP:0002415)1.77306615
118Proximal placement of thumb (HP:0009623)1.77242126
119Respiratory difficulties (HP:0002880)1.77100813
120Facial cleft (HP:0002006)1.76576249
121Duplication of thumb phalanx (HP:0009942)1.74944217
122Deviation of the thumb (HP:0009603)1.74832956
123Multiple enchondromatosis (HP:0005701)1.74664500
124Exercise intolerance (HP:0003546)1.74531053
125Abnormality of serum amino acid levels (HP:0003112)1.74076942
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.73976584
127Pulmonary fibrosis (HP:0002206)1.72421349
128Glioma (HP:0009733)1.72051931
129Hyperglycinuria (HP:0003108)1.71586565
130Embryonal neoplasm (HP:0002898)1.70892320
131Neoplasm of the oral cavity (HP:0100649)1.70403790
132Megaloblastic anemia (HP:0001889)1.69824087
133Abnormality of T cell physiology (HP:0011840)1.68950919
134Intestinal atresia (HP:0011100)1.68784471
135Poikiloderma (HP:0001029)1.68418248
136Cutaneous melanoma (HP:0012056)1.67842469
137Cortical dysplasia (HP:0002539)1.66384380
138Astigmatism (HP:0000483)1.65263246
139Preaxial hand polydactyly (HP:0001177)1.62790554
140Respiratory failure (HP:0002878)1.62575739
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.61862641
142Small hand (HP:0200055)1.61785434
143Abnormality of serine family amino acid metabolism (HP:0010894)1.60621514
144Abnormality of glycine metabolism (HP:0010895)1.60621514
145Exertional dyspnea (HP:0002875)1.59978237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.75252526
2BUB14.69925780
3WEE14.57274883
4EIF2AK13.15142649
5VRK23.11746238
6NEK22.76017082
7NME22.50690338
8TTK2.45028229
9SRPK12.41327768
10BRSK22.22935472
11STK162.16539060
12NEK12.07604838
13PLK42.04837446
14ACVR1B1.94999472
15EIF2AK31.91834340
16PLK11.90426709
17VRK11.89436588
18TGFBR11.84972527
19TSSK61.84769064
20CDK71.83689015
21MST41.83164795
22ATR1.78118310
23AURKB1.68213283
24MKNK11.68099607
25RPS6KA41.67865122
26TESK21.61958493
27PASK1.57769003
28TAF11.53442874
29RPS6KB21.52112171
30ZAK1.48970878
31TLK11.48418081
32BRSK11.42141277
33DYRK31.41961889
34PLK31.40295918
35CHEK21.38639024
36MAP3K81.37271491
37STK101.36223607
38TRIM281.35198190
39CDK41.32292807
40CCNB11.30634272
41SCYL21.25150534
42NME11.24864380
43EEF2K1.24056313
44CDK121.23923889
45CHEK11.14145721
46BMPR1B1.13785244
47STK41.12328440
48AURKA1.08946744
49MKNK21.08295665
50WNK31.04319890
51CDK81.03799976
52TNIK1.00327431
53PIM20.99587812
54PIM10.98884601
55PNCK0.98579204
56MAP3K100.94320729
57PAK40.94007701
58MAP4K10.93670900
59LRRK20.91094472
60FLT30.87990405
61ATM0.86343446
62STK38L0.84698567
63MAP4K20.82915384
64BRD40.81803715
65CDK20.80020592
66BCKDK0.79725886
67EPHA20.76383451
68KDR0.71394170
69PKN20.69903287
70CDK60.69676845
71CLK10.69401107
72PLK20.69170653
73PDK20.67779850
74BTK0.67495834
75EIF2AK20.67316630
76STK30.66929637
77BRAF0.63858816
78TEC0.63636401
79CSNK2A10.62834383
80CSNK2A20.61885448
81CDK10.58114269
82CSNK1G10.58002857
83ALK0.57880550
84MELK0.57528827
85BCR0.56468086
86GRK60.55243911
87ERBB40.54138606
88RPS6KA50.53058630
89MAP2K30.51953627
90TESK10.49531348
91DAPK10.49502846
92CSNK1G30.49439163
93PAK10.47895698
94DYRK20.45517811
95ERBB30.44921487
96IRAK40.44546420
97FGFR10.42471501
98CSF1R0.41823825
99CDK30.40876123
100LATS10.39043012
101INSRR0.38240005
102KIT0.37736329
103CSNK1E0.37610384
104CSNK1G20.36764610
105JAK30.36328656
106CSNK1A1L0.35425597
107TYK20.34362422
108TGFBR20.33559089
109STK390.32903517
110MAP3K40.32465364
111TAOK20.32093562
112MARK30.31336500
113RPS6KA60.29271747
114ZAP700.29258359
115RAF10.28551676
116PRKCI0.28448986
117MAPKAPK50.27740642
118RPS6KC10.27131406
119RPS6KL10.27131406
120PBK0.25487080
121PRKDC0.25056191
122LYN0.23863380
123MAP2K70.23290191
124CDK90.23010515
125NEK90.22875288
126AKT20.22737390
127CDK180.21530743
128NUAK10.21493479
129MAPK140.20593604
130MAPKAPK30.20490628
131STK240.19852621
132MAP3K110.19793058
133BLK0.19618080
134MAPK110.19316271
135MTOR0.18758627

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.70502268
2Mismatch repair_Homo sapiens_hsa034304.76118425
3Homologous recombination_Homo sapiens_hsa034403.43096255
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41640866
5Ribosome_Homo sapiens_hsa030103.34062143
6* Base excision repair_Homo sapiens_hsa034103.28241119
7Spliceosome_Homo sapiens_hsa030403.18736311
8* Nucleotide excision repair_Homo sapiens_hsa034202.98797114
9RNA transport_Homo sapiens_hsa030132.94525816
10Cell cycle_Homo sapiens_hsa041102.94042979
11Proteasome_Homo sapiens_hsa030502.89494194
12RNA polymerase_Homo sapiens_hsa030202.85884518
13One carbon pool by folate_Homo sapiens_hsa006702.71820306
14* Pyrimidine metabolism_Homo sapiens_hsa002402.50899114
15Fanconi anemia pathway_Homo sapiens_hsa034602.45735479
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12809098
17Non-homologous end-joining_Homo sapiens_hsa034502.05888954
18RNA degradation_Homo sapiens_hsa030181.96995349
19Oxidative phosphorylation_Homo sapiens_hsa001901.83789380
20Parkinsons disease_Homo sapiens_hsa050121.73271486
21p53 signaling pathway_Homo sapiens_hsa041151.72023304
22Basal transcription factors_Homo sapiens_hsa030221.69571341
23mRNA surveillance pathway_Homo sapiens_hsa030151.58806525
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52313153
25Propanoate metabolism_Homo sapiens_hsa006401.46455394
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45171274
27Pyruvate metabolism_Homo sapiens_hsa006201.33325474
28Systemic lupus erythematosus_Homo sapiens_hsa053221.30691108
29* Purine metabolism_Homo sapiens_hsa002301.30085258
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14711275
31Epstein-Barr virus infection_Homo sapiens_hsa051691.10882525
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10529950
33Fatty acid elongation_Homo sapiens_hsa000621.09621615
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07327256
35Steroid biosynthesis_Homo sapiens_hsa001001.06410320
36Herpes simplex infection_Homo sapiens_hsa051681.02769545
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01486785
38Antigen processing and presentation_Homo sapiens_hsa046121.01282744
39Viral carcinogenesis_Homo sapiens_hsa052030.95674475
40Alzheimers disease_Homo sapiens_hsa050100.91629283
41Folate biosynthesis_Homo sapiens_hsa007900.89834706
42Oocyte meiosis_Homo sapiens_hsa041140.87912164
43Pentose phosphate pathway_Homo sapiens_hsa000300.79901697
44* HTLV-I infection_Homo sapiens_hsa051660.75930849
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.75888940
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75194890
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75169730
48Primary immunodeficiency_Homo sapiens_hsa053400.75163426
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72824790
50Selenocompound metabolism_Homo sapiens_hsa004500.67700711
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.67476479
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.66946734
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65521369
54Biosynthesis of amino acids_Homo sapiens_hsa012300.63617325
55Protein export_Homo sapiens_hsa030600.63503276
56Small cell lung cancer_Homo sapiens_hsa052220.62731547
57MicroRNAs in cancer_Homo sapiens_hsa052060.60503639
58Thyroid cancer_Homo sapiens_hsa052160.58029410
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57938974
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56075549
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55892924
62Legionellosis_Homo sapiens_hsa051340.53708817
63Fatty acid metabolism_Homo sapiens_hsa012120.52254477
64Sulfur relay system_Homo sapiens_hsa041220.50996581
65Apoptosis_Homo sapiens_hsa042100.50495666
66N-Glycan biosynthesis_Homo sapiens_hsa005100.49398049
67Glutathione metabolism_Homo sapiens_hsa004800.49036341
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48287018
69Butanoate metabolism_Homo sapiens_hsa006500.47805737
70Measles_Homo sapiens_hsa051620.45691776
71Vitamin B6 metabolism_Homo sapiens_hsa007500.45565403
72Hepatitis B_Homo sapiens_hsa051610.45549472
73Lysine degradation_Homo sapiens_hsa003100.43820354
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42452677
75Alcoholism_Homo sapiens_hsa050340.42448364
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.38885161
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37463062
78Colorectal cancer_Homo sapiens_hsa052100.36910544
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35306097
80Chronic myeloid leukemia_Homo sapiens_hsa052200.35109629
81Shigellosis_Homo sapiens_hsa051310.35089122
82Fatty acid degradation_Homo sapiens_hsa000710.34246499
83Peroxisome_Homo sapiens_hsa041460.33916674
84Arginine and proline metabolism_Homo sapiens_hsa003300.32812984
85Hematopoietic cell lineage_Homo sapiens_hsa046400.32791379
86Cardiac muscle contraction_Homo sapiens_hsa042600.32214213
87Carbon metabolism_Homo sapiens_hsa012000.31732163
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31603074
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.31052512
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30611550
91Acute myeloid leukemia_Homo sapiens_hsa052210.29932577
92Nitrogen metabolism_Homo sapiens_hsa009100.29487832
93Huntingtons disease_Homo sapiens_hsa050160.28968798
94TGF-beta signaling pathway_Homo sapiens_hsa043500.28175677
95Viral myocarditis_Homo sapiens_hsa054160.26857178
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26564293
97Influenza A_Homo sapiens_hsa051640.26370864
98Phototransduction_Homo sapiens_hsa047440.25686827
99Bladder cancer_Homo sapiens_hsa052190.24792583
100Hippo signaling pathway_Homo sapiens_hsa043900.23614225
101Pathways in cancer_Homo sapiens_hsa052000.23424783
102Basal cell carcinoma_Homo sapiens_hsa052170.22245841
103Non-small cell lung cancer_Homo sapiens_hsa052230.21769516
104Galactose metabolism_Homo sapiens_hsa000520.21663334
105beta-Alanine metabolism_Homo sapiens_hsa004100.20661518
106HIF-1 signaling pathway_Homo sapiens_hsa040660.20140894
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20049525
108Renin-angiotensin system_Homo sapiens_hsa046140.19549727
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18821331
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18613062
111Tryptophan metabolism_Homo sapiens_hsa003800.18595281
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18386727
113Notch signaling pathway_Homo sapiens_hsa043300.17807839
114Wnt signaling pathway_Homo sapiens_hsa043100.17231938
115Pancreatic cancer_Homo sapiens_hsa052120.15802255
116Prostate cancer_Homo sapiens_hsa052150.15334873
117Leishmaniasis_Homo sapiens_hsa051400.15295341
118Fructose and mannose metabolism_Homo sapiens_hsa000510.14853652
119Arachidonic acid metabolism_Homo sapiens_hsa005900.14418212
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14092101
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13911371
122* Metabolic pathways_Homo sapiens_hsa011000.13707610
123Hedgehog signaling pathway_Homo sapiens_hsa043400.13608117
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13397284
125Olfactory transduction_Homo sapiens_hsa047400.13360090
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12834658
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12626364
128B cell receptor signaling pathway_Homo sapiens_hsa046620.11446607
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11150918
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10573475
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.10015338
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.09714191
133Caffeine metabolism_Homo sapiens_hsa002320.08832946
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.08511790
135Tyrosine metabolism_Homo sapiens_hsa003500.06742420
136Sulfur metabolism_Homo sapiens_hsa009200.05179458
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04884169
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.04760388

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »