POLE4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.85472720
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.51243487
3DNA strand elongation involved in DNA replication (GO:0006271)4.87145663
4DNA replication initiation (GO:0006270)4.85874487
5telomere maintenance via semi-conservative replication (GO:0032201)4.84316181
6ATP synthesis coupled proton transport (GO:0015986)4.79620233
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.79620233
8DNA strand elongation (GO:0022616)4.66696904
9chaperone-mediated protein transport (GO:0072321)4.61482433
10ribosomal small subunit assembly (GO:0000028)4.52797646
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.43887234
12respiratory electron transport chain (GO:0022904)4.43025121
13DNA replication checkpoint (GO:0000076)4.32654914
14telomere maintenance via recombination (GO:0000722)4.32513786
15mitotic metaphase plate congression (GO:0007080)4.31271605
16electron transport chain (GO:0022900)4.29227351
17CENP-A containing nucleosome assembly (GO:0034080)4.24565579
18maturation of SSU-rRNA (GO:0030490)4.15358616
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.12602916
20chromatin remodeling at centromere (GO:0031055)4.11786086
212-deoxyribonucleotide biosynthetic process (GO:0009265)3.98006349
22deoxyribose phosphate biosynthetic process (GO:0046385)3.98006349
23translation (GO:0006412)3.97700427
24mitotic recombination (GO:0006312)3.92861969
25regulation of mitochondrial translation (GO:0070129)3.89104140
26DNA replication-independent nucleosome organization (GO:0034724)3.88615306
27DNA replication-independent nucleosome assembly (GO:0006336)3.88615306
28telomere maintenance via telomere lengthening (GO:0010833)3.87257462
29viral transcription (GO:0019083)3.86535333
30protein targeting to mitochondrion (GO:0006626)3.85621776
31protein localization to kinetochore (GO:0034501)3.83924690
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.83065789
33translational termination (GO:0006415)3.81791682
34negative regulation of ligase activity (GO:0051352)3.80419146
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.80419146
36proteasome assembly (GO:0043248)3.78441247
37nucleobase-containing small molecule interconversion (GO:0015949)3.76190749
38metaphase plate congression (GO:0051310)3.75853354
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.73747082
40deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.70441332
41regulation of cellular amino acid metabolic process (GO:0006521)3.70073935
42ribosomal small subunit biogenesis (GO:0042274)3.65855141
43purine nucleobase biosynthetic process (GO:0009113)3.63304271
44protein neddylation (GO:0045116)3.63129400
45nucleobase biosynthetic process (GO:0046112)3.62066283
46purine nucleotide salvage (GO:0032261)3.61628472
47protein localization to chromosome, centromeric region (GO:0071459)3.60848863
48attachment of spindle microtubules to kinetochore (GO:0008608)3.57202041
49establishment of protein localization to mitochondrion (GO:0072655)3.55898490
50protein complex biogenesis (GO:0070271)3.55526104
51ribosome biogenesis (GO:0042254)3.55509941
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.53671243
53translational elongation (GO:0006414)3.53547556
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.52498297
55ribonucleoprotein complex biogenesis (GO:0022613)3.51471772
56mitochondrial respiratory chain complex assembly (GO:0033108)3.51195479
57rRNA modification (GO:0000154)3.49977006
58DNA unwinding involved in DNA replication (GO:0006268)3.49506009
59cellular component biogenesis (GO:0044085)3.49195211
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.48086487
61protein maturation by protein folding (GO:0022417)3.47887514
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.47754028
63maturation of 5.8S rRNA (GO:0000460)3.43701745
64pseudouridine synthesis (GO:0001522)3.43663012
65formation of translation preinitiation complex (GO:0001731)3.41700478
66antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.40718447
67translational initiation (GO:0006413)3.39935441
68DNA replication-dependent nucleosome organization (GO:0034723)3.39219403
69DNA replication-dependent nucleosome assembly (GO:0006335)3.39219403
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.38756239
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.38756239
72transcription-coupled nucleotide-excision repair (GO:0006283)3.37987612
73histone exchange (GO:0043486)3.37469057
74establishment of chromosome localization (GO:0051303)3.36199906
75protein localization to mitochondrion (GO:0070585)3.33396823
76oxidative phosphorylation (GO:0006119)3.33370034
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33364987
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33364987
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33364987
80deoxyribonucleotide biosynthetic process (GO:0009263)3.32028170
81pyrimidine nucleotide catabolic process (GO:0006244)3.32004967
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.30861661
83mitotic nuclear envelope disassembly (GO:0007077)3.29378106
84deoxyribonucleotide catabolic process (GO:0009264)3.27912959
85kinetochore organization (GO:0051383)3.27613907
86ribosome assembly (GO:0042255)3.27179291
87ribosomal large subunit biogenesis (GO:0042273)3.26864676
88nucleoside salvage (GO:0043174)3.26592287
89rRNA processing (GO:0006364)3.26500559
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.25551130
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25551130
92folic acid-containing compound biosynthetic process (GO:0009396)3.23623382
93kinetochore assembly (GO:0051382)3.23594194
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22243660
95protein targeting to membrane (GO:0006612)3.22167284
96mitotic chromosome condensation (GO:0007076)3.22064157
97mitochondrial respiratory chain complex I assembly (GO:0032981)3.21506939
98NADH dehydrogenase complex assembly (GO:0010257)3.21506939
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21506939
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20643317
101protein complex disassembly (GO:0043241)3.19896389
102positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19422787
103deoxyribose phosphate catabolic process (GO:0046386)3.18974038
104signal transduction involved in cell cycle checkpoint (GO:0072395)3.17111856
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16062470
106rRNA metabolic process (GO:0016072)3.15257606
107protein K6-linked ubiquitination (GO:0085020)3.14673320
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14575970
109pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13810961
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09144483
111positive regulation of ligase activity (GO:0051351)3.08056177
112nucleotide salvage (GO:0043173)3.07554830
113spliceosomal snRNP assembly (GO:0000387)3.07350017
114cotranslational protein targeting to membrane (GO:0006613)3.07112255
115meiotic chromosome segregation (GO:0045132)3.06037021
116macromolecular complex disassembly (GO:0032984)3.05038373
117protein targeting to ER (GO:0045047)3.04542367
118GDP-mannose metabolic process (GO:0019673)3.02881723
119nuclear envelope disassembly (GO:0051081)3.02814606
120membrane disassembly (GO:0030397)3.02814606
1212-deoxyribonucleotide metabolic process (GO:0009394)3.01244203
122rRNA methylation (GO:0031167)3.00548276
123G1/S transition of mitotic cell cycle (GO:0000082)2.99296717
124cell cycle G1/S phase transition (GO:0044843)2.99296717
125viral life cycle (GO:0019058)2.99196339
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97621815
127protein deneddylation (GO:0000338)2.95891883
128telomere maintenance (GO:0000723)2.95508171
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95141546
130cellular protein complex disassembly (GO:0043624)2.95030182
131regulation of nuclear cell cycle DNA replication (GO:0033262)2.94986708
132chromatin assembly or disassembly (GO:0006333)2.94879058
133telomere organization (GO:0032200)2.94784017
134termination of RNA polymerase III transcription (GO:0006386)2.93824184
135transcription elongation from RNA polymerase III promoter (GO:0006385)2.93824184
136deoxyribose phosphate metabolic process (GO:0019692)2.93554047
137mismatch repair (GO:0006298)2.93040991
138protein localization to endoplasmic reticulum (GO:0070972)2.92473300
139guanosine-containing compound biosynthetic process (GO:1901070)2.92336837
140RNA capping (GO:0036260)2.92012360
1417-methylguanosine RNA capping (GO:0009452)2.92012360
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90939258
143regulation of ubiquitin-protein transferase activity (GO:0051438)2.90783036
1447-methylguanosine mRNA capping (GO:0006370)2.90042083
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.89346479
146somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89346479
147folic acid metabolic process (GO:0046655)2.88265133
148establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87649040
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85292024
150isotype switching (GO:0045190)2.85292024
151somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85292024
152purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.83931390
153mitochondrial transport (GO:0006839)2.83376807
154base-excision repair, AP site formation (GO:0006285)2.83046763
155regulation of ligase activity (GO:0051340)2.82454411
156regulation of spindle organization (GO:0090224)2.82437802
157pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.82430323
158pyrimidine nucleoside salvage (GO:0043097)2.81745555
159pyrimidine-containing compound salvage (GO:0008655)2.81745555
160positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81583056
161regulation of cellular amine metabolic process (GO:0033238)2.81277831
162GTP biosynthetic process (GO:0006183)2.81227262
163establishment of integrated proviral latency (GO:0075713)2.81052945
164mitotic sister chromatid segregation (GO:0000070)2.80105067
165IMP biosynthetic process (GO:0006188)2.79413411
166pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.78580590
167regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76821940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.95822211
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.27012493
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66234273
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.50992594
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41927581
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27945477
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13949462
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.10975484
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01269556
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90857729
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.86504848
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.82073767
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73420968
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71344323
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55953108
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51263290
17VDR_23849224_ChIP-Seq_CD4+_Human2.41966490
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29941103
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28060263
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24453599
21XRN2_22483619_ChIP-Seq_HELA_Human2.23069732
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19629751
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16499885
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.16341740
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13717332
26DCP1A_22483619_ChIP-Seq_HELA_Human2.11234916
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08805345
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05052261
29AR_21909140_ChIP-Seq_LNCAP_Human2.03639123
30* GABP_19822575_ChIP-Seq_HepG2_Human2.03298921
31FOXP3_21729870_ChIP-Seq_TREG_Human2.02847012
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93093475
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92548449
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90551046
35* E2F1_21310950_ChIP-Seq_MCF-7_Human1.90362329
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87644112
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85960484
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84331788
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81868393
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81747060
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81579886
42TTF2_22483619_ChIP-Seq_HELA_Human1.77188753
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.74205786
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70245414
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66856533
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65205094
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64705045
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.62547552
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59732589
50MYC_22102868_ChIP-Seq_BL_Human1.59613561
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58821856
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58556378
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54044618
54ELK1_19687146_ChIP-ChIP_HELA_Human1.50541293
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49807657
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48150535
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46722493
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46648543
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.45890380
60CIITA_25753668_ChIP-Seq_RAJI_Human1.45006038
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42348982
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40140279
63KDM5A_27292631_Chip-Seq_BREAST_Human1.38780655
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35472226
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30872174
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27242259
67MYC_18940864_ChIP-ChIP_HL60_Human1.25904087
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25451236
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24724736
70* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23054522
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21149827
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20702221
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19514055
74ZNF263_19887448_ChIP-Seq_K562_Human1.18954370
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.18466078
76SPI1_23547873_ChIP-Seq_NB4_Human1.17597915
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17084454
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15738127
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15012875
80* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14427999
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12958034
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12224586
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12218386
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11347165
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10732100
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09580188
87VDR_21846776_ChIP-Seq_THP-1_Human1.08193797
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05906951
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05772284
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.03159992
91TFEB_21752829_ChIP-Seq_HELA_Human1.03117578
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00566179
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00555598
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.00253429
95CTCF_26484167_Chip-Seq_Bcells_Mouse0.98089189
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97463307
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96027101
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95756806
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.95530588
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95466775
101IRF8_21731497_ChIP-ChIP_J774_Mouse0.94567869
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93701164
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93143093
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91209283
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91070844
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90961769
107PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90342870
108FOXP1_21924763_ChIP-Seq_HESCs_Human0.90170214
109MAF_26560356_Chip-Seq_TH2_Human0.89525561
110MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88453772
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87591261
112ELK1_22589737_ChIP-Seq_MCF10A_Human0.85595503
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84037851
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83479018
115MYB_26560356_Chip-Seq_TH2_Human0.81614052
116MYB_26560356_Chip-Seq_TH1_Human0.81181033
117STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78791929
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77670564
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77375950
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77210167
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76629105
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76595350
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76287949
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76193534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.09355441
2MP0010094_abnormal_chromosome_stability4.58898249
3MP0004957_abnormal_blastocyst_morpholog4.07760909
4MP0003111_abnormal_nucleus_morphology3.94723945
5MP0003077_abnormal_cell_cycle3.74796420
6MP0008058_abnormal_DNA_repair3.23371215
7MP0008057_abnormal_DNA_replication3.20837237
8MP0005058_abnormal_lysosome_morphology3.01723364
9MP0008007_abnormal_cellular_replicative2.84578180
10MP0002396_abnormal_hematopoietic_system2.74413304
11MP0003718_maternal_effect2.61292431
12MP0003763_abnormal_thymus_physiology2.53546213
13MP0002148_abnormal_hypersensitivity_rea2.50196140
14MP0002877_abnormal_melanocyte_morpholog2.26454947
15MP0005408_hypopigmentation2.21461538
16MP0008932_abnormal_embryonic_tissue2.21316624
17MP0000343_altered_response_to2.18903384
18MP0000490_abnormal_crypts_of2.15983347
19MP0003786_premature_aging2.09362680
20MP0002102_abnormal_ear_morphology2.01656143
21MP0003646_muscle_fatigue1.96709808
22MP0009333_abnormal_splenocyte_physiolog1.96553118
23MP0000350_abnormal_cell_proliferation1.86788318
24MP0008260_abnormal_autophagy1.83986689
25MP0001545_abnormal_hematopoietic_system1.77695415
26MP0005397_hematopoietic_system_phenotyp1.77695415
27MP0002019_abnormal_tumor_incidence1.77525597
28MP0002398_abnormal_bone_marrow1.70485954
29MP0006292_abnormal_olfactory_placode1.68465604
30MP0005671_abnormal_response_to1.63708296
31MP0001730_embryonic_growth_arrest1.63329560
32MP0004808_abnormal_hematopoietic_stem1.63289064
33MP0008877_abnormal_DNA_methylation1.60120933
34MP0001542_abnormal_bone_strength1.58990707
35MP0000685_abnormal_immune_system1.57562104
36MP0001835_abnormal_antigen_presentation1.56615593
37MP0000689_abnormal_spleen_morphology1.56226655
38MP0006082_CNS_inflammation1.55262679
39MP0009840_abnormal_foam_cell1.54484485
40MP0003123_paternal_imprinting1.54000029
41MP0001764_abnormal_homeostasis1.53805071
42MP0002722_abnormal_immune_system1.48120634
43MP0002419_abnormal_innate_immunity1.46543449
44MP0009379_abnormal_foot_pigmentation1.46257901
45MP0001119_abnormal_female_reproductive1.45584456
46MP0003186_abnormal_redox_activity1.43210934
47MP0000703_abnormal_thymus_morphology1.42068818
48MP0002210_abnormal_sex_determination1.40290444
49MP0001790_abnormal_immune_system1.38737442
50MP0005387_immune_system_phenotype1.38737442
51MP0001697_abnormal_embryo_size1.38409709
52MP0009785_altered_susceptibility_to1.38164213
53MP0003191_abnormal_cellular_cholesterol1.37571539
54MP0000313_abnormal_cell_death1.36923269
55MP0001853_heart_inflammation1.35969175
56MP0001800_abnormal_humoral_immune1.34633677
57MP0010307_abnormal_tumor_latency1.32548200
58MP0008469_abnormal_protein_level1.29187050
59MP0005501_abnormal_skin_physiology1.28879503
60MP0002132_abnormal_respiratory_system1.28739240
61MP0002429_abnormal_blood_cell1.27138440
62MP0000716_abnormal_immune_system1.25091668
63MP0001929_abnormal_gametogenesis1.24352225
64MP0000653_abnormal_sex_gland1.23097880
65MP0001873_stomach_inflammation1.22059819
66MP0001727_abnormal_embryo_implantation1.21515705
67MP0002080_prenatal_lethality1.21155526
68MP0005451_abnormal_body_composition1.19869445
69MP0001145_abnormal_male_reproductive1.17139420
70MP0002405_respiratory_system_inflammati1.17137347
71MP0002420_abnormal_adaptive_immunity1.17127587
72MP0001819_abnormal_immune_cell1.15085643
73MP0002006_tumorigenesis1.13533659
74MP0002723_abnormal_immune_serum1.12004564
75MP0002452_abnormal_antigen_presenting1.11941053
76MP0000858_altered_metastatic_potential1.10765988
77MP0001672_abnormal_embryogenesis/_devel1.09651828
78MP0005380_embryogenesis_phenotype1.09651828
79MP0003075_altered_response_to1.09132444
80MP0002095_abnormal_skin_pigmentation1.08952376
81MP0005360_urolithiasis1.08422294
82MP0009764_decreased_sensitivity_to1.05817088
83MP0005166_decreased_susceptibility_to1.04950196
84MP0000750_abnormal_muscle_regeneration1.04764522
85MP0003699_abnormal_female_reproductive1.03756931
86MP0002085_abnormal_embryonic_tissue1.02511566
87MP0001881_abnormal_mammary_gland1.01933167
88MP0005075_abnormal_melanosome_morpholog1.01000580
89MP0005319_abnormal_enzyme/_coenzyme1.00327312
90MP0003315_abnormal_perineum_morphology0.99742357
91MP0004947_skin_inflammation0.99693375
92MP0003806_abnormal_nucleotide_metabolis0.99553054
93MP0003724_increased_susceptibility_to0.99064443
94MP0003567_abnormal_fetal_cardiomyocyte0.97578470
95MP0006036_abnormal_mitochondrial_physio0.96228731
96MP0000371_diluted_coat_color0.95824676
97MP0000465_gastrointestinal_hemorrhage0.95532047
98MP0008875_abnormal_xenobiotic_pharmacok0.94803400
99MP0003448_altered_tumor_morphology0.94374039
100MP0010352_gastrointestinal_tract_polyps0.93726037
101MP0000372_irregular_coat_pigmentation0.93286719
102MP0005000_abnormal_immune_tolerance0.93264528
103MP0009763_increased_sensitivity_to0.92865320
104MP0003866_abnormal_defecation0.92536079
105MP0005330_cardiomyopathy0.92392551
106MP0005025_abnormal_response_to0.92252278
107MP0003984_embryonic_growth_retardation0.92028896
108MP0003221_abnormal_cardiomyocyte_apopto0.91474487
109MP0005165_increased_susceptibility_to0.91014090
110MP0002166_altered_tumor_susceptibility0.90133944
111MP0002086_abnormal_extraembryonic_tissu0.89450209
112MP0003436_decreased_susceptibility_to0.88984726
113MP0002088_abnormal_embryonic_growth/wei0.88525283
114MP0001905_abnormal_dopamine_level0.87967751
115MP0002277_abnormal_respiratory_mucosa0.87811538
116MP0003941_abnormal_skin_development0.86953841
117MP0005389_reproductive_system_phenotype0.86380465
118MP0002796_impaired_skin_barrier0.86213784
119MP0001919_abnormal_reproductive_system0.85870845
120MP0002653_abnormal_ependyma_morphology0.85735656
121MP0008873_increased_physiological_sensi0.85602160
122MP0002084_abnormal_developmental_patter0.84530205
123MP0000678_abnormal_parathyroid_gland0.82359390
124MP0000358_abnormal_cell_content/0.81395187
125MP0005395_other_phenotype0.80198528
126MP0005174_abnormal_tail_pigmentation0.79922680
127MP0003656_abnormal_erythrocyte_physiolo0.77596569
128MP0005584_abnormal_enzyme/coenzyme_acti0.77495003
129MP0009278_abnormal_bone_marrow0.76879922
130MP0010155_abnormal_intestine_physiology0.74909263
131MP0005266_abnormal_metabolism0.73230269
132MP0006035_abnormal_mitochondrial_morpho0.71548621
133MP0001533_abnormal_skeleton_physiology0.71328786
134MP0000749_muscle_degeneration0.71283800
135MP0003303_peritoneal_inflammation0.71149389
136MP0005464_abnormal_platelet_physiology0.70377252
137MP0002160_abnormal_reproductive_system0.70164070
138MP0000681_abnormal_thyroid_gland0.69323810
139MP0003011_delayed_dark_adaptation0.69255351
140MP0000477_abnormal_intestine_morphology0.65559584
141MP0006054_spinal_hemorrhage0.63014501
142MP0002638_abnormal_pupillary_reflex0.62643354
143MP0001845_abnormal_inflammatory_respons0.61175891
144MP0005384_cellular_phenotype0.61012949
145MP0009697_abnormal_copulation0.60932850
146MP0000015_abnormal_ear_pigmentation0.60709828

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.77619525
2Acute necrotizing encephalopathy (HP:0006965)5.72138024
3Birth length less than 3rd percentile (HP:0003561)5.61312653
4Mitochondrial inheritance (HP:0001427)5.39390346
5Acute encephalopathy (HP:0006846)4.85443065
6Increased CSF lactate (HP:0002490)4.65205330
7Abnormality of cells of the erythroid lineage (HP:0012130)4.56329831
8Abnormal number of erythroid precursors (HP:0012131)4.54770850
9Progressive macrocephaly (HP:0004481)4.51810659
10Oral leukoplakia (HP:0002745)4.36380145
11Increased intramyocellular lipid droplets (HP:0012240)4.36221838
12Hepatic necrosis (HP:0002605)4.24762932
13Breast hypoplasia (HP:0003187)4.22452585
14Increased hepatocellular lipid droplets (HP:0006565)4.18705767
15Aplastic anemia (HP:0001915)4.15434359
16Reticulocytopenia (HP:0001896)4.06353684
17Renal Fanconi syndrome (HP:0001994)4.04875737
18Increased muscle lipid content (HP:0009058)3.85930368
19Lipid accumulation in hepatocytes (HP:0006561)3.72919527
20Cerebral edema (HP:0002181)3.69462571
21Microretrognathia (HP:0000308)3.44209157
22Lactic acidosis (HP:0003128)3.40174402
23Exercise intolerance (HP:0003546)3.35762165
24Respiratory failure (HP:0002878)3.29663008
25Patellar aplasia (HP:0006443)3.21063263
26B lymphocytopenia (HP:0010976)3.16817589
27Thrombocytosis (HP:0001894)3.11614596
28Chromsome breakage (HP:0040012)3.09699078
29Aplasia/Hypoplasia of the patella (HP:0006498)2.99313884
30Rough bone trabeculation (HP:0100670)2.98930072
31Muscle fiber atrophy (HP:0100295)2.98231140
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.96279210
33Abnormality of alanine metabolism (HP:0010916)2.96279210
34Hyperalaninemia (HP:0003348)2.96279210
35Male infertility (HP:0003251)2.88256094
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88178851
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88178851
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85234915
39Poikiloderma (HP:0001029)2.84825954
40Colon cancer (HP:0003003)2.84233724
41Pallor (HP:0000980)2.83757728
42Macrocytic anemia (HP:0001972)2.83642261
43Premature graying of hair (HP:0002216)2.82883813
44IgM deficiency (HP:0002850)2.80332768
45Entropion (HP:0000621)2.80063135
46Type 2 muscle fiber atrophy (HP:0003554)2.78230384
47Secondary amenorrhea (HP:0000869)2.76992918
48Abnormality of B cell number (HP:0010975)2.76394994
49Increased serum pyruvate (HP:0003542)2.76094934
50Premature ovarian failure (HP:0008209)2.75665121
51Ragged-red muscle fibers (HP:0003200)2.71413267
52Abnormality of the preputium (HP:0100587)2.70584858
53Myelodysplasia (HP:0002863)2.69852762
54Carpal bone hypoplasia (HP:0001498)2.64928370
55Abnormality of chromosome stability (HP:0003220)2.59879420
56Meckel diverticulum (HP:0002245)2.56773563
57Abnormality of renal resorption (HP:0011038)2.54952248
58Supernumerary spleens (HP:0009799)2.53938929
59IgG deficiency (HP:0004315)2.52502759
60Abnormality of glycolipid metabolism (HP:0010969)2.52386559
61Abnormality of liposaccharide metabolism (HP:0010968)2.52386559
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.52386559
63Abnormality of the ileum (HP:0001549)2.49546995
64Basal cell carcinoma (HP:0002671)2.43896474
65Pulmonary fibrosis (HP:0002206)2.43162953
66Leukodystrophy (HP:0002415)2.41612062
67Bone marrow hypocellularity (HP:0005528)2.39539066
68Pancytopenia (HP:0001876)2.37319584
69Esophageal neoplasm (HP:0100751)2.36591629
70Neoplasm of head and neck (HP:0012288)2.36591629
71Agnosia (HP:0010524)2.35197674
72Cellular immunodeficiency (HP:0005374)2.32925051
73CNS demyelination (HP:0007305)2.31266020
74Facial hemangioma (HP:0000329)2.30562319
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.28944136
76Absent thumb (HP:0009777)2.28511111
77Neoplasm of the pancreas (HP:0002894)2.28371880
78Hepatosplenomegaly (HP:0001433)2.28087200
79Generalized aminoaciduria (HP:0002909)2.27113048
80Lymphoma (HP:0002665)2.26653638
81Emotional lability (HP:0000712)2.26110925
82Degeneration of anterior horn cells (HP:0002398)2.25015966
83Abnormality of the anterior horn cell (HP:0006802)2.25015966
84Abnormality of DNA repair (HP:0003254)2.23712472
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20835756
86Abnormality of the heme biosynthetic pathway (HP:0010472)2.18925689
87Elevated erythrocyte sedimentation rate (HP:0003565)2.18271658
88Optic disc pallor (HP:0000543)2.17496509
89Rhabdomyosarcoma (HP:0002859)2.17365356
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16886919
91Abnormal protein N-linked glycosylation (HP:0012347)2.16886919
92Abnormal protein glycosylation (HP:0012346)2.16886919
93Abnormal glycosylation (HP:0012345)2.16886919
94Combined immunodeficiency (HP:0005387)2.16783826
95Testicular atrophy (HP:0000029)2.15448134
96Obstructive lung disease (HP:0006536)2.14834661
97Chronic obstructive pulmonary disease (HP:0006510)2.14834661
98Selective tooth agenesis (HP:0001592)2.13066739
99Reduced antithrombin III activity (HP:0001976)2.13064700
100Dicarboxylic aciduria (HP:0003215)2.12911215
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12911215
102Cerebral hypomyelination (HP:0006808)2.12688811
103Exertional dyspnea (HP:0002875)2.11679578
104Opisthotonus (HP:0002179)2.11662492
105Myositis (HP:0100614)2.11447949
106Medulloblastoma (HP:0002885)2.11328698
107Lethargy (HP:0001254)2.09393491
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08625295
109Squamous cell carcinoma (HP:0002860)2.08325223
110Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06238137
111Vertebral compression fractures (HP:0002953)2.05847898
112Sloping forehead (HP:0000340)2.03394640
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02705641
114Abnormal trabecular bone morphology (HP:0100671)2.02592549
115Acute myeloid leukemia (HP:0004808)2.02221288
116Multiple enchondromatosis (HP:0005701)1.99750188
117Type I transferrin isoform profile (HP:0003642)1.99696430
118Abnormality of placental membranes (HP:0011409)1.99012880
119Amniotic constriction ring (HP:0009775)1.99012880
1203-Methylglutaconic aciduria (HP:0003535)1.98721544
121Petechiae (HP:0000967)1.97292056
122Absent radius (HP:0003974)1.97082250
123Duodenal stenosis (HP:0100867)1.96268138
124Small intestinal stenosis (HP:0012848)1.96268138
125Severe combined immunodeficiency (HP:0004430)1.92541306
126Abnormal spermatogenesis (HP:0008669)1.92156700
127Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91962370
128Increased serum lactate (HP:0002151)1.90878461
129Abnormality of T cell physiology (HP:0011840)1.90840135
130Hypoplastic pelvis (HP:0008839)1.89895121
131Triphalangeal thumb (HP:0001199)1.89804305
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88672762
133Recurrent bronchitis (HP:0002837)1.86083187
134Slender long bone (HP:0003100)1.84834805
135Progressive neurologic deterioration (HP:0002344)1.84504057
136Irregular epiphyses (HP:0010582)1.84391005
137Abnormality of T cells (HP:0002843)1.83995428
138Progressive muscle weakness (HP:0003323)1.83486648
139Abnormality of macrophages (HP:0004311)1.83175444
140Capillary hemangiomas (HP:0005306)1.82884541
141Microvesicular hepatic steatosis (HP:0001414)1.82609035
142Abnormality of lateral ventricle (HP:0030047)1.82604483
143Absent forearm bone (HP:0003953)1.82320648
144Aplasia involving forearm bones (HP:0009822)1.82320648
145Nasal polyposis (HP:0100582)1.80129138
146Gastrointestinal stroma tumor (HP:0100723)1.79367940
147Sparse eyelashes (HP:0000653)1.79236617
148Nausea (HP:0002018)1.78920416
149Mediastinal lymphadenopathy (HP:0100721)1.78572581
150Hypergonadotropic hypogonadism (HP:0000815)1.78247844
151Horseshoe kidney (HP:0000085)1.77878015
152Clubbing of toes (HP:0100760)1.77359216
153Hepatocellular necrosis (HP:0001404)1.77174378
154Reduced subcutaneous adipose tissue (HP:0003758)1.77040526
155Vacuolated lymphocytes (HP:0001922)1.76920573
156Respiratory difficulties (HP:0002880)1.75980518
157Abnormality of glycolysis (HP:0004366)1.74282036
158Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72693765
159Progressive microcephaly (HP:0000253)1.72229675
160Posterior subcapsular cataract (HP:0007787)1.72053758
161Methylmalonic aciduria (HP:0012120)1.71979855
162Rhabdomyolysis (HP:0003201)1.71533733
163Congenital ichthyosiform erythroderma (HP:0007431)1.70184233
164Abnormality of the umbilical cord (HP:0010881)1.70022665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.06608154
2VRK23.95492233
3WEE13.91475897
4CDC73.45189522
5ACVR1B3.00149239
6NME22.93599780
7EIF2AK12.74625607
8STK162.64274241
9TESK12.62604362
10IRAK32.48669360
11NEK22.45343566
12PLK42.41616505
13BRSK21.94722230
14TTK1.91426568
15MAPKAPK31.90291858
16DYRK31.89417253
17VRK11.85438479
18TESK21.80055551
19SRPK11.79457059
20PLK11.76435832
21LIMK11.76278330
22MAP4K11.72660458
23CDK81.71835688
24EIF2AK31.70379655
25MOS1.69372523
26RAF11.63959993
27ILK1.62796107
28MAP3K61.61996261
29RPS6KA41.57313000
30PBK1.56734397
31AURKB1.45054844
32CHEK21.39748777
33CDK71.39527063
34RPS6KB21.38374108
35SCYL21.35770018
36MUSK1.35557665
37BRAF1.35234548
38TLK11.30439945
39EEF2K1.28666058
40STK101.26390187
41MST41.25615370
42KIT1.25401268
43PIM21.23532555
44MAP3K81.23028894
45KDR1.21233010
46CCNB11.18423760
47AURKA1.13723782
48CDK41.13204510
49BRSK11.12195851
50MAP3K111.10839673
51MYLK1.09992655
52ATR1.09235636
53BMPR21.08460143
54DYRK21.07525801
55CSNK1G31.07387144
56MKNK11.06264422
57TGFBR11.05443835
58TXK1.05336680
59ERN11.04148942
60FLT31.02543389
61MKNK21.01026892
62ARAF0.99811618
63NEK10.96116787
64PIM10.94708332
65RIPK40.91002842
66TEC0.89493412
67JAK30.88445798
68PDK20.87856861
69LATS20.84195555
70CDK190.83993464
71SMG10.83712609
72DAPK30.82633426
73TAOK20.80661333
74MAP3K30.79522618
75NLK0.77704336
76CSNK1G10.76364529
77TAOK10.75805003
78PLK30.75732534
79GRK70.75447331
80MAP3K130.75170099
81TAOK30.73972790
82PRKCI0.73551539
83ZAP700.72710506
84LRRK20.72661836
85IRAK40.69338526
86IKBKB0.69026378
87TYK20.67923214
88MAPK110.67103915
89TSSK60.66128069
90CSNK1A1L0.65247311
91MELK0.64674098
92SIK30.63999696
93DAPK10.63082159
94ABL20.61218668
95CHEK10.61006570
96BCKDK0.60054775
97KSR20.59645597
98CDK90.58254263
99CSNK1G20.57002232
100STK40.56378413
101EIF2AK20.54798436
102GRK50.54644124
103CSNK2A10.53537947
104BTK0.52119968
105TBK10.51226451
106PAK40.50795988
107STK240.50475382
108NME10.50366310
109CAMK2G0.47571097
110ATM0.47510895
111CSF1R0.46881801
112CDK140.45824607
113CSK0.45593766
114MAP3K50.45051022
115PASK0.44710087
116PAK10.44673624
117GRK60.44478229
118STK38L0.44107926
119RPS6KA50.42931302
120LMTK20.42653824
121CDK20.42262533
122TRIM280.41909609
123CSNK2A20.41870120
124MAP2K30.41683437
125PINK10.41455491
126SYK0.40403330
127LYN0.39979459
128NEK90.39559532
129CLK10.38750741
130CDK11A0.37719233
131MAP3K120.37536852
132KSR10.35914282
133ZAK0.35512834
134MST1R0.34849370
135TGFBR20.34665035
136PRKG20.34196525
137IKBKE0.32293095
138CDK180.29199677

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.10790180
2Mismatch repair_Homo sapiens_hsa034304.42643853
3Ribosome_Homo sapiens_hsa030103.70738462
4RNA polymerase_Homo sapiens_hsa030203.50001581
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37290082
6* Base excision repair_Homo sapiens_hsa034103.11598697
7Homologous recombination_Homo sapiens_hsa034403.07851971
8Proteasome_Homo sapiens_hsa030503.01985868
9* Nucleotide excision repair_Homo sapiens_hsa034202.95644518
10Cell cycle_Homo sapiens_hsa041102.87750265
11Spliceosome_Homo sapiens_hsa030402.83455950
12* Pyrimidine metabolism_Homo sapiens_hsa002402.66498317
13RNA transport_Homo sapiens_hsa030132.66121167
14Alzheimers disease_Homo sapiens_hsa050102.40629044
15Fanconi anemia pathway_Homo sapiens_hsa034602.25878396
16RNA degradation_Homo sapiens_hsa030182.24662551
17Basal transcription factors_Homo sapiens_hsa030222.18994396
18One carbon pool by folate_Homo sapiens_hsa006701.91091025
19Non-homologous end-joining_Homo sapiens_hsa034501.75397420
20p53 signaling pathway_Homo sapiens_hsa041151.70990909
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61487629
22Folate biosynthesis_Homo sapiens_hsa007901.49161926
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46983069
24Sulfur metabolism_Homo sapiens_hsa009201.40867462
25* Purine metabolism_Homo sapiens_hsa002301.39523086
26Primary immunodeficiency_Homo sapiens_hsa053401.32373715
27mRNA surveillance pathway_Homo sapiens_hsa030151.29976115
28Fatty acid elongation_Homo sapiens_hsa000621.27612571
29Vitamin B6 metabolism_Homo sapiens_hsa007501.23009079
30Cardiac muscle contraction_Homo sapiens_hsa042601.21562229
31Sulfur relay system_Homo sapiens_hsa041221.16747913
32Herpes simplex infection_Homo sapiens_hsa051681.11394335
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.09162537
34Epstein-Barr virus infection_Homo sapiens_hsa051691.02831607
35Rheumatoid arthritis_Homo sapiens_hsa053230.95241190
36Oocyte meiosis_Homo sapiens_hsa041140.94620296
37Fructose and mannose metabolism_Homo sapiens_hsa000510.92372093
38Autoimmune thyroid disease_Homo sapiens_hsa053200.89145427
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88192055
40Antigen processing and presentation_Homo sapiens_hsa046120.85237960
41Galactose metabolism_Homo sapiens_hsa000520.82969006
42Pyruvate metabolism_Homo sapiens_hsa006200.81933885
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.78787312
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78695593
45Thyroid cancer_Homo sapiens_hsa052160.78355311
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78286005
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75350639
48Biosynthesis of amino acids_Homo sapiens_hsa012300.74335282
49Systemic lupus erythematosus_Homo sapiens_hsa053220.73222036
50Pentose phosphate pathway_Homo sapiens_hsa000300.71954906
51Graft-versus-host disease_Homo sapiens_hsa053320.71892947
52Other glycan degradation_Homo sapiens_hsa005110.69021017
53Measles_Homo sapiens_hsa051620.68916890
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68685441
55Protein export_Homo sapiens_hsa030600.66987991
56Vibrio cholerae infection_Homo sapiens_hsa051100.63927852
57Shigellosis_Homo sapiens_hsa051310.62561958
58Huntingtons disease_Homo sapiens_hsa050160.62159032
59Viral carcinogenesis_Homo sapiens_hsa052030.60187440
60* HTLV-I infection_Homo sapiens_hsa051660.59872703
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58472077
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57936038
63Lysosome_Homo sapiens_hsa041420.56455986
64Hepatitis B_Homo sapiens_hsa051610.55576763
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.55119739
66Collecting duct acid secretion_Homo sapiens_hsa049660.54632540
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53501998
68Viral myocarditis_Homo sapiens_hsa054160.53453604
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53171110
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.52991250
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52532263
72Apoptosis_Homo sapiens_hsa042100.52147065
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51264340
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51237273
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50717559
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49157282
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49082722
78Hematopoietic cell lineage_Homo sapiens_hsa046400.49071007
79Colorectal cancer_Homo sapiens_hsa052100.46534286
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.46270112
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45597742
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.42230980
83Small cell lung cancer_Homo sapiens_hsa052220.42141630
84B cell receptor signaling pathway_Homo sapiens_hsa046620.42030516
85Salmonella infection_Homo sapiens_hsa051320.41910458
86Glutathione metabolism_Homo sapiens_hsa004800.41130179
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.39511731
88Legionellosis_Homo sapiens_hsa051340.39146939
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38940423
90Influenza A_Homo sapiens_hsa051640.37461859
91Staphylococcus aureus infection_Homo sapiens_hsa051500.37426669
92Parkinsons disease_Homo sapiens_hsa050120.37253862
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36973733
94Allograft rejection_Homo sapiens_hsa053300.36592234
95Circadian rhythm_Homo sapiens_hsa047100.36144112
96Pancreatic cancer_Homo sapiens_hsa052120.35780776
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34660972
98TGF-beta signaling pathway_Homo sapiens_hsa043500.34510037
99Selenocompound metabolism_Homo sapiens_hsa004500.34068138
100MicroRNAs in cancer_Homo sapiens_hsa052060.32410454
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32181568
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31975093
103Phagosome_Homo sapiens_hsa041450.31727403
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31689988
105Acute myeloid leukemia_Homo sapiens_hsa052210.30678338
106T cell receptor signaling pathway_Homo sapiens_hsa046600.30232383
107Arginine and proline metabolism_Homo sapiens_hsa003300.29982453
108Regulation of autophagy_Homo sapiens_hsa041400.29462530
109Tyrosine metabolism_Homo sapiens_hsa003500.29446948
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29333891
111Leishmaniasis_Homo sapiens_hsa051400.28423809
112Peroxisome_Homo sapiens_hsa041460.27882312
113Caffeine metabolism_Homo sapiens_hsa002320.26770862
114* Metabolic pathways_Homo sapiens_hsa011000.25633321
115Tuberculosis_Homo sapiens_hsa051520.25204240
116N-Glycan biosynthesis_Homo sapiens_hsa005100.25116478
117Pertussis_Homo sapiens_hsa051330.24908741
118Phenylalanine metabolism_Homo sapiens_hsa003600.24844897
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24815742
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24751772
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23966089
122Type I diabetes mellitus_Homo sapiens_hsa049400.23645862
123Carbon metabolism_Homo sapiens_hsa012000.23420243
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22623083
125Asthma_Homo sapiens_hsa053100.21970038
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21345280
127Bladder cancer_Homo sapiens_hsa052190.20974603
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20115464
129Chronic myeloid leukemia_Homo sapiens_hsa052200.17196686
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15102959
131Oxidative phosphorylation_Homo sapiens_hsa001900.14809672
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14667803
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13649352
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12372580
135VEGF signaling pathway_Homo sapiens_hsa043700.11461793
136Prolactin signaling pathway_Homo sapiens_hsa049170.11150795

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