POLG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.60231928
2polyketide metabolic process (GO:0030638)6.60231928
3doxorubicin metabolic process (GO:0044598)6.60231928
4protein localization to kinetochore (GO:0034501)5.48260181
5nuclear pore complex assembly (GO:0051292)5.08245633
6histone H4-K12 acetylation (GO:0043983)5.03314743
7heterochromatin organization (GO:0070828)5.02713290
8positive regulation of histone deacetylation (GO:0031065)4.95677977
9regulation of telomere maintenance via telomerase (GO:0032210)4.92649560
10negative regulation of telomerase activity (GO:0051974)4.81583164
11maintenance of protein location in nucleus (GO:0051457)4.77485527
12negative regulation of epidermis development (GO:0045683)4.68781701
13positive regulation of gamma-delta T cell activation (GO:0046645)4.66444420
14negative regulation of erythrocyte differentiation (GO:0045647)4.66359729
15histone H4-K5 acetylation (GO:0043981)4.65156152
16histone H4-K8 acetylation (GO:0043982)4.65156152
17negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.64454514
18negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.59631821
19nuclear pore organization (GO:0006999)4.57705146
20pre-miRNA processing (GO:0031054)4.53631415
21mitotic sister chromatid segregation (GO:0000070)4.47407420
22chromatin assembly (GO:0031497)4.45772125
23regulation of mammary gland epithelial cell proliferation (GO:0033599)4.41221599
24protein localization to chromosome, centromeric region (GO:0071459)4.39800530
25DNA replication-dependent nucleosome organization (GO:0034723)4.39347471
26DNA replication-dependent nucleosome assembly (GO:0006335)4.39347471
27somite rostral/caudal axis specification (GO:0032525)4.28947089
28muscle organ morphogenesis (GO:0048644)4.28563299
29positive regulation of protein deacetylation (GO:0090312)4.26213311
30RNA stabilization (GO:0043489)4.12643410
31mRNA stabilization (GO:0048255)4.12643410
32negative regulation of cell cycle G2/M phase transition (GO:1902750)4.11863906
33regulation of nuclear cell cycle DNA replication (GO:0033262)4.10967833
34aminoglycoside antibiotic metabolic process (GO:0030647)4.06122182
35sister chromatid segregation (GO:0000819)3.98844031
36pore complex assembly (GO:0046931)3.98290815
37regulation of response to osmotic stress (GO:0047484)3.93982952
38regulation of gene silencing by miRNA (GO:0060964)3.93969020
39regulation of gene silencing by RNA (GO:0060966)3.93969020
40regulation of posttranscriptional gene silencing (GO:0060147)3.93969020
41maternal placenta development (GO:0001893)3.87131497
42positive thymic T cell selection (GO:0045059)3.84383616
43histone H4-K16 acetylation (GO:0043984)3.81055575
44regulation of MHC class I biosynthetic process (GO:0045343)3.79078851
45notochord development (GO:0030903)3.76570996
46interferon-gamma production (GO:0032609)3.72909743
47mannose metabolic process (GO:0006013)3.71198556
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70735908
49thymic T cell selection (GO:0045061)3.68609864
50rRNA transcription (GO:0009303)3.66988748
51negative regulation of cell killing (GO:0031342)3.65189417
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65189417
53cellular modified amino acid catabolic process (GO:0042219)3.57931673
54trophectodermal cell differentiation (GO:0001829)3.54195995
55cytidine metabolic process (GO:0046087)3.50464266
56cytidine catabolic process (GO:0006216)3.50464266
57cytidine deamination (GO:0009972)3.50464266
58primitive streak formation (GO:0090009)3.49625581
59hormone catabolic process (GO:0042447)3.49464152
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49292279
61regulation of gamma-delta T cell differentiation (GO:0045586)3.48015302
62antigen processing and presentation of endogenous antigen (GO:0019883)3.47880705
63regulation of gamma-delta T cell activation (GO:0046643)3.46202253
64DNA duplex unwinding (GO:0032508)3.39102574
65DNA geometric change (GO:0032392)3.34006999
66regulation of translation in response to stress (GO:0043555)3.29358597
67negative regulation of epidermal cell differentiation (GO:0045605)3.27714647
68regulation of apoptotic process involved in morphogenesis (GO:1902337)3.24498131
69NIK/NF-kappaB signaling (GO:0038061)3.23966634
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23759521
71NLS-bearing protein import into nucleus (GO:0006607)3.23123133
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.22015556
73branching involved in mammary gland duct morphogenesis (GO:0060444)3.21573493
74response to muramyl dipeptide (GO:0032495)3.20937950
75positive regulation of DNA-dependent DNA replication (GO:2000105)3.20353375
76response to laminar fluid shear stress (GO:0034616)3.18826408
77mitotic chromosome condensation (GO:0007076)3.17612523
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16834823
79regulation of hippo signaling (GO:0035330)3.13639615
80T cell selection (GO:0045058)3.12213945
81negative thymic T cell selection (GO:0045060)3.11624240
82regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.10614654
83entrainment of circadian clock by photoperiod (GO:0043153)3.10399831
84apoptotic process involved in morphogenesis (GO:0060561)3.09174069
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08418641
86positive regulation by organism of defense response of other organism involved in symbiotic interact3.08418641
87modulation by symbiont of host immune response (GO:0052553)3.08418641
88positive regulation by symbiont of host defense response (GO:0052509)3.08418641
89modulation by symbiont of host defense response (GO:0052031)3.08418641
90modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08418641
91positive T cell selection (GO:0043368)3.04644510
92omega-hydroxylase P450 pathway (GO:0097267)3.02799398
93negative T cell selection (GO:0043383)3.01762929
94epoxygenase P450 pathway (GO:0019373)3.00209276
95intracellular estrogen receptor signaling pathway (GO:0030520)2.99776082
96DNA replication checkpoint (GO:0000076)2.99107267
97regulation of type I interferon-mediated signaling pathway (GO:0060338)2.97938120
98DNA unwinding involved in DNA replication (GO:0006268)2.97025633
99positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96557049
100response to peptidoglycan (GO:0032494)2.95885997
101negative regulation of cell size (GO:0045792)2.95218446
102B cell receptor signaling pathway (GO:0050853)2.93463880
103receptor recycling (GO:0001881)2.93213638
104regulation of B cell receptor signaling pathway (GO:0050855)2.91914141
105coenzyme catabolic process (GO:0009109)2.90204638
106embryonic process involved in female pregnancy (GO:0060136)2.89595096
107leukocyte aggregation (GO:0070486)2.89007581
108pinocytosis (GO:0006907)2.86690722
109retinoic acid receptor signaling pathway (GO:0048384)2.85542505
110detection of other organism (GO:0098543)2.85261762
111detection of bacterium (GO:0016045)2.84942768
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83522656
113modulation by symbiont of host cellular process (GO:0044068)2.82740416
114negative regulation of telomere maintenance (GO:0032205)2.81526320
115chromosome condensation (GO:0030261)2.78998368
116intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.78841812
117histone H3-K4 methylation (GO:0051568)2.76033985
118response to dietary excess (GO:0002021)2.75718265
119cell migration involved in gastrulation (GO:0042074)2.75618203
120protein localization to endosome (GO:0036010)2.72599335
121regulation of telomerase activity (GO:0051972)2.72175651
122intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.69592756
1233-UTR-mediated mRNA stabilization (GO:0070935)2.69412076
124regulation of cilium movement (GO:0003352)2.68521454
125spliceosomal tri-snRNP complex assembly (GO:0000244)2.68230277
126negative regulation of bone resorption (GO:0045779)2.67605795
127embryonic placenta development (GO:0001892)2.65694778
128regulation of interleukin-2 biosynthetic process (GO:0045076)2.65468212
129regulation of NFAT protein import into nucleus (GO:0051532)2.64348858
130macrophage activation involved in immune response (GO:0002281)2.64041393
131pyrimidine ribonucleoside catabolic process (GO:0046133)2.63747101
132mucosal-associated lymphoid tissue development (GO:0048537)2.63685529
133Peyers patch development (GO:0048541)2.63685529
134spindle assembly (GO:0051225)2.63348210
135regulation of gene silencing (GO:0060968)2.63035703
136activation of Rac GTPase activity (GO:0032863)2.62968246
137positive regulation of Cdc42 GTPase activity (GO:0043089)2.62939504
138DNA conformation change (GO:0071103)2.62757032
139determination of adult lifespan (GO:0008340)2.62709322
140regulation of telomere maintenance (GO:0032204)2.62372058
141histone H3 acetylation (GO:0043966)2.62301123
142regulation of necroptotic process (GO:0060544)2.62022865
143folic acid-containing compound biosynthetic process (GO:0009396)2.61774512
144negative regulation of DNA biosynthetic process (GO:2000279)2.59831126
145response to interleukin-15 (GO:0070672)2.59538521
146cell fate commitment involved in formation of primary germ layer (GO:0060795)2.58425707
147epithelial cell differentiation involved in prostate gland development (GO:0060742)2.57345379
148negative regulation of histone methylation (GO:0031061)2.56302221
149cellular hyperosmotic response (GO:0071474)2.55035074
150mitochondrion distribution (GO:0048311)2.54834097
151regulation of mRNA stability (GO:0043488)2.54674316
152T cell migration (GO:0072678)2.53728327
153regulation of histone H3-K27 methylation (GO:0061085)2.53394881
154COPI coating of Golgi vesicle (GO:0048205)2.53375730
155Golgi transport vesicle coating (GO:0048200)2.53375730
156lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52872512
157modulation by virus of host process (GO:0019054)2.52798397
158negative regulation of myotube differentiation (GO:0010832)2.50572398
159positive regulation of B cell differentiation (GO:0045579)2.50345644
160negative regulation of necroptotic process (GO:0060546)2.49588019
161germinal center formation (GO:0002467)2.47869926
162histone H3-K36 demethylation (GO:0070544)2.45107404
163focal adhesion assembly (GO:0048041)2.44235901
164cell-substrate adherens junction assembly (GO:0007045)2.44235901
165negative regulation of viral release from host cell (GO:1902187)2.43845658
166cellular response to interleukin-4 (GO:0071353)2.42630536
167cellular response to virus (GO:0098586)2.40505748
168adherens junction assembly (GO:0034333)2.37656088
169regulation of interferon-beta biosynthetic process (GO:0045357)2.34633156
170natural killer cell differentiation (GO:0001779)2.33264276
171response to interleukin-4 (GO:0070670)2.30604491
172negative regulation of phagocytosis (GO:0050765)2.30092268
173regulation of early endosome to late endosome transport (GO:2000641)2.29389605
174regulation of integrin activation (GO:0033623)2.28519380
175regulation of B cell differentiation (GO:0045577)2.27237258
176regulation of leukocyte degranulation (GO:0043300)2.27015317
177antigen processing and presentation via MHC class Ib (GO:0002475)2.26025474
178negative regulation of interleukin-12 production (GO:0032695)2.25163845
179pentose-phosphate shunt (GO:0006098)2.25106639
180type I interferon signaling pathway (GO:0060337)2.23895770
181cellular response to type I interferon (GO:0071357)2.23895770
182regulation of nucleobase-containing compound transport (GO:0032239)2.23806282
183response to type I interferon (GO:0034340)2.22820329
184regulation of defense response to virus by virus (GO:0050690)2.21459444
185detection of external biotic stimulus (GO:0098581)2.21276069
186regulation of glucose import in response to insulin stimulus (GO:2001273)2.20499475
187regulation of necrotic cell death (GO:0010939)2.20098086
188negative regulation of leukocyte mediated immunity (GO:0002704)2.20070738
189positive regulation of keratinocyte differentiation (GO:0045618)2.20051469
190myeloid dendritic cell differentiation (GO:0043011)2.19888183
191regulation of monocyte differentiation (GO:0045655)2.19244662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.09995507
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.88865823
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.88865823
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.88865823
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.80654264
6* FOXM1_23109430_ChIP-Seq_U2OS_Human3.29861549
7MYC_22102868_ChIP-Seq_BL_Human2.86304120
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.78703871
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.59576856
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.38231402
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36126451
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32415960
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.31063074
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.25288983
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.14505324
16STAT3_1855785_ChIP-Seq_MESCs_Mouse2.04896121
17TCF7_22412390_ChIP-Seq_EML_Mouse2.02327359
18SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.00396269
19VDR_24763502_ChIP-Seq_THP-1_Human1.96399961
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.96248580
21TCF3_18692474_ChIP-Seq_MESCs_Mouse1.95049734
22TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88994901
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85517916
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83800416
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83763757
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80348604
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78917832
28* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78448742
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77147768
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.77113788
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.75859872
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66539728
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63868507
34* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63562326
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63236297
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.60315557
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60158518
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59973117
39* RUNX1_22412390_ChIP-Seq_EML_Mouse1.58763697
40* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58613060
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57592858
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57292379
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56902703
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54845432
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52633605
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51789159
47VDR_21846776_ChIP-Seq_THP-1_Human1.51252913
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50593067
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50014382
50NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.49031229
51KDM2B_26808549_Chip-Seq_DND41_Human1.47865249
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47129968
53ZNF263_19887448_ChIP-Seq_K562_Human1.45399745
54* NCOR1_26117541_ChIP-Seq_K562_Human1.45333894
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44242208
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41795705
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40818654
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.40589298
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40328661
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39967235
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37127188
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35303412
63SCL_19346495_ChIP-Seq_HPC-7_Human1.34167125
64TP53_22127205_ChIP-Seq_IMR90_Human1.34105738
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33490580
66POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32849407
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32379114
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31116226
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30150010
70* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29440594
71* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28810519
72MAF_26560356_Chip-Seq_TH1_Human1.25974514
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25237740
74* SPI1_23547873_ChIP-Seq_NB4_Human1.23830604
75LXR_22292898_ChIP-Seq_THP-1_Human1.23742921
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21595020
77* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21476644
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20179169
79* MYB_26560356_Chip-Seq_TH2_Human1.20172211
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19737274
81TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19547290
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19429857
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.18849741
84* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.18075998
85PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17843733
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17563909
87PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17258359
88* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17213802
89* RACK7_27058665_Chip-Seq_MCF-7_Human1.16911635
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14862966
91SPI1_23127762_ChIP-Seq_K562_Human1.14834778
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14662587
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.13898799
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.13491198
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11773816
96* UTX_26944678_Chip-Seq_JUKART_Human1.11729294
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11300164
98SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11090443
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10926517
100IRF8_27001747_Chip-Seq_BMDM_Mouse1.10890426
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10567462
102CLOCK_20551151_ChIP-Seq_293T_Human1.10172977
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10166720
104KDM2B_26808549_Chip-Seq_K562_Human1.09237378
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09234987
106* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08572287
107GATA1_19941827_ChIP-Seq_MEL_Mouse1.07679130
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07579515
109* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06832298
110NANOG_21062744_ChIP-ChIP_HESCs_Human1.06608629
111NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06510177
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06202134
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05240786
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04535279
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04267926
116CDX2_20551321_ChIP-Seq_CACO-2_Human1.03931680
117* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03515809
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.03243500
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02803344
120* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02654957
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02627128
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02465729
123* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02448398
124CIITA_25753668_ChIP-Seq_RAJI_Human1.02062687
125P68_20966046_ChIP-Seq_HELA_Human1.02054736
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01592823
127FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01490876
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01444314
129MYB_26560356_Chip-Seq_TH1_Human1.01078852
130GATA1_22025678_ChIP-Seq_K562_Human1.00591746
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.00495697
132ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00078924
133NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99853089
134BCOR_27268052_Chip-Seq_Bcells_Human0.99557481
135* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99504931
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97957515
137ATF3_27146783_Chip-Seq_COLON_Human0.97895355
138CTCF_21964334_Chip-Seq_Bcells_Human0.97521236
139ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97275848
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97233685
141BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96843718
142* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95860254
143MAF_26560356_Chip-Seq_TH2_Human0.93895405
144* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92012631
145RXR_22158963_ChIP-Seq_LIVER_Mouse0.91836440
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91566049
147ELF1_20517297_ChIP-Seq_JURKAT_Human0.90835754
148SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89319224
149* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88748402
150* KDM2B_26808549_Chip-Seq_JURKAT_Human0.88153428
151SMC4_20622854_ChIP-Seq_HELA_Human0.87783010
152* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87725326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.86641901
2MP0003705_abnormal_hypodermis_morpholog3.75947544
3MP0003011_delayed_dark_adaptation3.55490649
4MP0004264_abnormal_extraembryonic_tissu3.49393515
5MP0005451_abnormal_body_composition3.25897391
6MP0003890_abnormal_embryonic-extraembry2.79136979
7* MP0003763_abnormal_thymus_physiology2.78856467
8MP0003436_decreased_susceptibility_to2.74249641
9MP0005075_abnormal_melanosome_morpholog2.40283056
10MP0004957_abnormal_blastocyst_morpholog2.39714645
11MP0010352_gastrointestinal_tract_polyps2.33595913
12MP0008961_abnormal_basal_metabolism2.29958107
13MP0008260_abnormal_autophagy2.29101610
14MP0005257_abnormal_intraocular_pressure2.28723026
15MP0005058_abnormal_lysosome_morphology2.19667045
16MP0001835_abnormal_antigen_presentation2.18149414
17MP0003183_abnormal_peptide_metabolism2.14260715
18MP0002332_abnormal_exercise_endurance2.11516039
19MP0009333_abnormal_splenocyte_physiolog2.08994200
20MP0009278_abnormal_bone_marrow2.03077313
21* MP0005380_embryogenesis_phenotype2.02302770
22* MP0001672_abnormal_embryogenesis/_devel2.02302770
23MP0002877_abnormal_melanocyte_morpholog2.02231334
24MP0004858_abnormal_nervous_system1.99121757
25* MP0002088_abnormal_embryonic_growth/wei1.96496620
26MP0009840_abnormal_foam_cell1.95893861
27MP0002653_abnormal_ependyma_morphology1.95173769
28MP0008057_abnormal_DNA_replication1.93912241
29* MP0003984_embryonic_growth_retardation1.93710720
30MP0004947_skin_inflammation1.87931723
31MP0001800_abnormal_humoral_immune1.85387099
32MP0005000_abnormal_immune_tolerance1.81969550
33MP0003121_genomic_imprinting1.81947582
34MP0003122_maternal_imprinting1.81136824
35MP0000685_abnormal_immune_system1.80785879
36MP0002086_abnormal_extraembryonic_tissu1.79794904
37MP0006292_abnormal_olfactory_placode1.76597668
38MP0005387_immune_system_phenotype1.75035243
39MP0001790_abnormal_immune_system1.75035243
40MP0003172_abnormal_lysosome_physiology1.75006444
41MP0003191_abnormal_cellular_cholesterol1.73849227
42MP0002398_abnormal_bone_marrow1.68547001
43MP0005499_abnormal_olfactory_system1.67621056
44MP0005394_taste/olfaction_phenotype1.67621056
45MP0005671_abnormal_response_to1.67607818
46MP0005025_abnormal_response_to1.66168154
47MP0003111_abnormal_nucleus_morphology1.65028626
48MP0002419_abnormal_innate_immunity1.64875700
49MP0002420_abnormal_adaptive_immunity1.63406660
50MP0001819_abnormal_immune_cell1.61666358
51MP0002723_abnormal_immune_serum1.60789026
52MP0000350_abnormal_cell_proliferation1.60359914
53MP0001873_stomach_inflammation1.60261432
54MP0002452_abnormal_antigen_presenting1.58150164
55MP0002396_abnormal_hematopoietic_system1.55139399
56MP0003123_paternal_imprinting1.51730294
57MP0006035_abnormal_mitochondrial_morpho1.50151473
58MP0004197_abnormal_fetal_growth/weight/1.46544908
59MP0005670_abnormal_white_adipose1.44578880
60MP0003077_abnormal_cell_cycle1.43907996
61MP0002405_respiratory_system_inflammati1.43267881
62MP0002084_abnormal_developmental_patter1.43001508
63MP0000716_abnormal_immune_system1.42371083
64MP0001730_embryonic_growth_arrest1.42003994
65MP0004185_abnormal_adipocyte_glucose1.41610137
66MP0002127_abnormal_cardiovascular_syste1.38454060
67MP0010155_abnormal_intestine_physiology1.38037119
68MP0001849_ear_inflammation1.37147293
69MP0002166_altered_tumor_susceptibility1.35328536
70MP0002085_abnormal_embryonic_tissue1.34740624
71MP0004233_abnormal_muscle_weight1.34134879
72MP0002009_preneoplasia1.33829131
73MP0002092_abnormal_eye_morphology1.33112189
74MP0010234_abnormal_vibrissa_follicle1.33051908
75MP0005076_abnormal_cell_differentiation1.32091757
76* MP0002429_abnormal_blood_cell1.30524652
77MP0010094_abnormal_chromosome_stability1.29289682
78MP0004381_abnormal_hair_follicle1.27197436
79MP0003566_abnormal_cell_adhesion1.26632774
80MP0005666_abnormal_adipose_tissue1.25733650
81MP0005023_abnormal_wound_healing1.24788214
82MP0005464_abnormal_platelet_physiology1.21324392
83MP0003806_abnormal_nucleotide_metabolis1.20253146
84MP0003119_abnormal_digestive_system1.19821650
85MP0000428_abnormal_craniofacial_morphol1.18807769
86MP0003300_gastrointestinal_ulcer1.18680831
87MP0001348_abnormal_lacrimal_gland1.18092184
88MP0003303_peritoneal_inflammation1.17235048
89MP0010030_abnormal_orbit_morphology1.16504625
90MP0009785_altered_susceptibility_to1.15436198
91* MP0002080_prenatal_lethality1.15318369
92MP0002925_abnormal_cardiovascular_devel1.15248393
93MP0001545_abnormal_hematopoietic_system1.14283639
94MP0005397_hematopoietic_system_phenotyp1.14283639
95MP0001293_anophthalmia1.14154389
96MP0001853_heart_inflammation1.13052597
97* MP0001697_abnormal_embryo_size1.12628936
98MP0008770_decreased_survivor_rate1.11315852
99MP0005266_abnormal_metabolism1.10263327
100MP0000609_abnormal_liver_physiology1.08134504
101MP0002148_abnormal_hypersensitivity_rea1.06479790
102MP0003724_increased_susceptibility_to1.05508695
103MP0003938_abnormal_ear_development1.05221183
104MP0002796_impaired_skin_barrier1.04761949
105MP0002998_abnormal_bone_remodeling1.04042707
106MP0001533_abnormal_skeleton_physiology1.03690603
107MP0010307_abnormal_tumor_latency1.03219832
108MP0000733_abnormal_muscle_development1.01973645
109MP0005409_darkened_coat_color1.01603117
110MP0002269_muscular_atrophy1.00333325
111MP0005621_abnormal_cell_physiology1.00157677
112MP0001845_abnormal_inflammatory_respons0.99850217
113MP0010368_abnormal_lymphatic_system0.98734184
114* MP0002970_abnormal_white_adipose0.97851487
115MP0008007_abnormal_cellular_replicative0.96192689
116MP0005360_urolithiasis0.94751727
117* MP0000490_abnormal_crypts_of0.94608150
118MP0002932_abnormal_joint_morphology0.94511622
119MP0008438_abnormal_cutaneous_collagen0.93958569
120MP0004272_abnormal_basement_membrane0.92984884
121MP0000678_abnormal_parathyroid_gland0.91912615
122MP0005310_abnormal_salivary_gland0.91463808
123MP0000432_abnormal_head_morphology0.91380165
124MP0005167_abnormal_blood-brain_barrier0.91114524
125MP0003935_abnormal_craniofacial_develop0.91040570
126MP0003828_pulmonary_edema0.89116168
127MP0005501_abnormal_skin_physiology0.88685720
128MP0004510_myositis0.88204592
129MP0003866_abnormal_defecation0.88198954
130MP0001851_eye_inflammation0.87124477
131MP0002006_tumorigenesis0.87040127
132MP0000465_gastrointestinal_hemorrhage0.86491535
133* MP0000313_abnormal_cell_death0.86411918
134MP0003091_abnormal_cell_migration0.85262888
135MP0003448_altered_tumor_morphology0.85004371
136MP0000003_abnormal_adipose_tissue0.84990160
137MP0002722_abnormal_immune_system0.83029338
138MP0003221_abnormal_cardiomyocyte_apopto0.82737249
139MP0000604_amyloidosis0.82605739
140MP0008469_abnormal_protein_level0.82173940
141MP0004808_abnormal_hematopoietic_stem0.81483689
142MP0000750_abnormal_muscle_regeneration0.81349031
143MP0000689_abnormal_spleen_morphology0.80644712
144MP0000858_altered_metastatic_potential0.80624201
145MP0009931_abnormal_skin_appearance0.80473444
146MP0000749_muscle_degeneration0.78123098
147MP0002139_abnormal_hepatobiliary_system0.76922168
148MP0000598_abnormal_liver_morphology0.76877919
149MP0000703_abnormal_thymus_morphology0.76699033
150MP0002019_abnormal_tumor_incidence0.76516189
151MP0003787_abnormal_imprinting0.76280020
152* MP0000266_abnormal_heart_morphology0.75832865
153MP0001216_abnormal_epidermal_layer0.75438839
154MP0005623_abnormal_meninges_morphology0.75223250
155* MP0010630_abnormal_cardiac_muscle0.75139519
156MP0005319_abnormal_enzyme/_coenzyme0.73571756
157MP0009115_abnormal_fat_cell0.73187149
158MP0006082_CNS_inflammation0.73107325
159MP0000762_abnormal_tongue_morphology0.69699934
160MP0009703_decreased_birth_body0.69503585
161MP0001915_intracranial_hemorrhage0.69121381
162MP0008932_abnormal_embryonic_tissue0.68291003
163MP0000767_abnormal_smooth_muscle0.67150319
164MP0003693_abnormal_embryo_hatching0.66371334
165MP0005375_adipose_tissue_phenotype0.66111748
166MP0000358_abnormal_cell_content/0.65551403
167MP0003453_abnormal_keratinocyte_physiol0.65430909

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.28920378
2Hypochromic microcytic anemia (HP:0004840)5.12636878
3Abnormality of the lower motor neuron (HP:0002366)4.67670571
4Multiple enchondromatosis (HP:0005701)4.36551568
5Ependymoma (HP:0002888)4.27388499
6Hepatoblastoma (HP:0002884)3.88254904
7Rib fusion (HP:0000902)3.75456217
8Neoplasm of striated muscle (HP:0009728)3.75118301
9Eczematoid dermatitis (HP:0000976)3.65637117
10Rhabdomyosarcoma (HP:0002859)3.48018773
11Increased connective tissue (HP:0009025)3.17457491
12Pseudobulbar signs (HP:0002200)3.12858957
13Hyperinsulinemic hypoglycemia (HP:0000825)2.95908602
14Abnormality of the astrocytes (HP:0100707)2.92015381
15Astrocytoma (HP:0009592)2.92015381
16Colitis (HP:0002583)2.87654174
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86768094
18Preauricular skin tag (HP:0000384)2.84162161
19Nephroblastoma (Wilms tumor) (HP:0002667)2.84108999
20Cellulitis (HP:0100658)2.83730011
21Impulsivity (HP:0100710)2.82158769
22Difficulty running (HP:0009046)2.80110477
23Skin tags (HP:0010609)2.78103295
24Hyperacusis (HP:0010780)2.76482749
25Hypopigmentation of the fundus (HP:0007894)2.75639036
26Intestinal fistula (HP:0100819)2.73325968
27Broad face (HP:0000283)2.71121216
28Abnormality of the fingertips (HP:0001211)2.70372662
29Achilles tendon contracture (HP:0001771)2.69864612
30Hypochromic anemia (HP:0001931)2.67184885
31Recurrent bacterial skin infections (HP:0005406)2.66624538
32Distal lower limb amyotrophy (HP:0008944)2.65658509
33Recurrent abscess formation (HP:0002722)2.64968453
34Recurrent viral infections (HP:0004429)2.63878671
35Heterotopia (HP:0002282)2.61370281
36Abnormality of the Achilles tendon (HP:0005109)2.60229335
37Embryonal renal neoplasm (HP:0011794)2.57701048
38Partial duplication of thumb phalanx (HP:0009944)2.53484973
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.53110995
40Abnormal cartilage morphology (HP:0002763)2.52875486
41Abnormality of the salivary glands (HP:0010286)2.52344703
42Rectovaginal fistula (HP:0000143)2.50612687
43Rectal fistula (HP:0100590)2.50612687
44Large earlobe (HP:0009748)2.49901106
45Gastrointestinal inflammation (HP:0004386)2.49378929
46Abnormality of macrophages (HP:0004311)2.48382786
47Chromsome breakage (HP:0040012)2.47826249
48Mediastinal lymphadenopathy (HP:0100721)2.47793033
49Increased IgE level (HP:0003212)2.47465844
50Short humerus (HP:0005792)2.43931364
51Nasal polyposis (HP:0100582)2.42997233
52Renal duplication (HP:0000075)2.42930960
53Fused cervical vertebrae (HP:0002949)2.41744284
54Aplasia/hypoplasia of the humerus (HP:0006507)2.34901411
55Vertebral compression fractures (HP:0002953)2.33193661
56Horizontal nystagmus (HP:0000666)2.32946817
57Partial duplication of the phalanx of hand (HP:0009999)2.31633706
58Abnormality of the nasal mucosa (HP:0000433)2.30305414
59Generalized hypotonia (HP:0001290)2.30287835
60Supernumerary ribs (HP:0005815)2.30186103
61Fatigue (HP:0012378)2.30145466
62Inflammation of the large intestine (HP:0002037)2.26927182
63Trismus (HP:0000211)2.26176468
64Thin bony cortex (HP:0002753)2.25602799
65Vaginal fistula (HP:0004320)2.23544432
66Meckel diverticulum (HP:0002245)2.21290333
67Recurrent fungal infections (HP:0002841)2.18620743
68Periauricular skin pits (HP:0100277)2.17635617
69Preauricular pit (HP:0004467)2.17635617
70Chronic obstructive pulmonary disease (HP:0006510)2.13770127
71Obstructive lung disease (HP:0006536)2.13770127
72Neoplasm of the heart (HP:0100544)2.12250057
73Hand muscle atrophy (HP:0009130)2.11095988
74Hyperglycinuria (HP:0003108)2.10941442
75Meningitis (HP:0001287)2.10585326
76Abnormality of the thoracic spine (HP:0100711)2.10400008
77Abnormality of oral frenula (HP:0000190)2.07988731
78Gingivitis (HP:0000230)2.07532161
79Upper motor neuron abnormality (HP:0002127)2.07380380
80Amyotrophic lateral sclerosis (HP:0007354)2.06017097
81Disproportionate tall stature (HP:0001519)2.04942420
82Abnormality of the ileum (HP:0001549)2.04867879
83Spinal cord lesions (HP:0100561)2.04797616
84Syringomyelia (HP:0003396)2.04797616
85Supernumerary bones of the axial skeleton (HP:0009144)2.04402077
86Dislocated radial head (HP:0003083)2.03965451
87Abnormality of the musculature of the hand (HP:0001421)2.01591469
88Combined immunodeficiency (HP:0005387)2.01220046
89Reticulocytosis (HP:0001923)2.00643680
90EMG: neuropathic changes (HP:0003445)2.00450513
91Reduced antithrombin III activity (HP:0001976)1.99244173
92Distal upper limb amyotrophy (HP:0007149)1.99123569
93Upper limb amyotrophy (HP:0009129)1.99123569
94Glioma (HP:0009733)1.98654334
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.98488571
96Short 5th finger (HP:0009237)1.98248362
97Cerebral aneurysm (HP:0004944)1.98215854
98Flat acetabular roof (HP:0003180)1.97255854
99Gastrointestinal stroma tumor (HP:0100723)1.96808304
100Thoracic kyphosis (HP:0002942)1.95827496
101Abnormality of the phalanges of the hallux (HP:0010057)1.95801853
102Myositis (HP:0100614)1.95434271
103Protrusio acetabuli (HP:0003179)1.94957479
104Abnormality of chromosome segregation (HP:0002916)1.94806256
105Adenoma sebaceum (HP:0009720)1.94261272
106Angiofibromas (HP:0010615)1.94261272
107Medulloblastoma (HP:0002885)1.94194904
108Slow saccadic eye movements (HP:0000514)1.91150730
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.90945042
110Missing ribs (HP:0000921)1.90156451
111Abnormal lung lobation (HP:0002101)1.90091461
112Prominent occiput (HP:0000269)1.90077321
113Selective tooth agenesis (HP:0001592)1.89605526
114Agammaglobulinemia (HP:0004432)1.88853958
115Villous atrophy (HP:0011473)1.86597712
116Abnormality of small intestinal villus morphology (HP:0011472)1.86597712
117Myopathic facies (HP:0002058)1.85699279
118Aplasia/Hypoplasia of the macula (HP:0008059)1.85287956
119Prominent nose (HP:0000448)1.85024306
120Ulnar bowing (HP:0003031)1.84513156
121Supernumerary spleens (HP:0009799)1.84466335
122T lymphocytopenia (HP:0005403)1.84301776
123Vertebral fusion (HP:0002948)1.83780729
124Long palpebral fissure (HP:0000637)1.83564668
125Hemiparesis (HP:0001269)1.83229115
126Increased cerebral lipofuscin (HP:0011813)1.83160329
127Abnormality of the radial head (HP:0003995)1.83156326
128Interstitial pulmonary disease (HP:0006530)1.82730951
129Skin pits (HP:0100276)1.82662997
130Hypertensive crisis (HP:0100735)1.81721072
131Dysmetric saccades (HP:0000641)1.81185535
132Hemorrhage of the eye (HP:0011885)1.81121418
133Upper limb muscle weakness (HP:0003484)1.80921117
134Increased nuchal translucency (HP:0010880)1.79543845
135Segmental peripheral demyelination/remyelination (HP:0003481)1.79373831
136Recurrent gram-negative bacterial infections (HP:0005420)1.79351594
137Malignant neoplasm of the central nervous system (HP:0100836)1.79326686
138Viral hepatitis (HP:0006562)1.79301577
139Spontaneous hematomas (HP:0007420)1.79071452
140Gastrointestinal infarctions (HP:0005244)1.78417248
141Aplasia/Hypoplasia affecting the retina (HP:0008061)1.78372417
142Recurrent skin infections (HP:0001581)1.78069143
143Ankyloglossia (HP:0010296)1.77818514
144Hypoplasia of the fovea (HP:0007750)1.77580998
145Aplasia/Hypoplasia of the fovea (HP:0008060)1.77580998
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77330410
147Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.76126248
148Lymphangioma (HP:0100764)1.75798070
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.75311794
150Loss of speech (HP:0002371)1.75008655
151Chronic mucocutaneous candidiasis (HP:0002728)1.73217600
152Recurrent cutaneous fungal infections (HP:0011370)1.73217600
153Broad alveolar ridges (HP:0000187)1.72111426
154Emphysema (HP:0002097)1.72074264
155Dysostosis multiplex (HP:0000943)1.71696431
156Atresia of the external auditory canal (HP:0000413)1.71188568
157Distal lower limb muscle weakness (HP:0009053)1.69934090
158Deep palmar crease (HP:0006191)1.68080568
159Abnormality of the peritoneum (HP:0002585)1.68072503
160Ventricular tachycardia (HP:0004756)1.67663366
161Osteomyelitis (HP:0002754)1.67092371
162Dilatation of the ascending aorta (HP:0005111)1.67005663
163Lower limb amyotrophy (HP:0007210)1.66056057
164Subacute progressive viral hepatitis (HP:0006572)1.65646398
165Osteolytic defects of the hand bones (HP:0009699)1.65616872
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.65616872
167Stridor (HP:0010307)1.64753405
168Pustule (HP:0200039)1.64381257
169Abnormality of liposaccharide metabolism (HP:0010968)1.63776757
170Abnormality of glycosphingolipid metabolism (HP:0004343)1.63776757
171Abnormality of glycolipid metabolism (HP:0010969)1.63776757
172Biconcave vertebral bodies (HP:0004586)1.63621151
173Orchitis (HP:0100796)1.63474067
174Papilloma (HP:0012740)1.62878001
175Verrucae (HP:0200043)1.62878001
176Obstructive sleep apnea (HP:0002870)1.62613012
177Metaphyseal cupping (HP:0003021)1.61557143
178Abnormality of cells of the lymphoid lineage (HP:0012140)1.60269029
179Abnormal delayed hypersensitivity skin test (HP:0002963)1.60154921
180Persistence of primary teeth (HP:0006335)1.58565834
181Lymphopenia (HP:0001888)1.58021804
182Abnormality of the calcaneus (HP:0008364)1.57563328
183Polygenic inheritance (HP:0010982)1.56964993
184Exercise-induced myalgia (HP:0003738)1.56456675
185Broad distal phalanx of finger (HP:0009836)1.56005079
186Vasculitis (HP:0002633)1.55563199
187Aneurysm (HP:0002617)1.55224101
188Abnormal gallbladder physiology (HP:0012438)1.52383547
189Cholecystitis (HP:0001082)1.52383547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.59687160
2ERN13.92517650
3PRPF4B3.92136732
4GRK63.77799092
5SMG13.33243965
6GRK52.91517471
7MAP3K102.77197676
8IRAK32.50176799
9STK102.45917137
10TYRO32.32942582
11TGFBR22.32649822
12CSF1R2.24315220
13GRK12.10774793
14TRIB32.08265129
15TTK2.00243893
16PKN21.86555300
17RIPK41.82507682
18MAP3K131.77557085
19TYK21.67199823
20MAPK71.60475131
21MAP3K141.51349923
22EEF2K1.51049524
23TLK11.50250480
24IRAK41.44307298
25WNK11.41852609
26TAOK21.40442669
27MAP3K71.39199439
28TTN1.36697831
29FGFR31.31200167
30NEK21.30811033
31MATK1.26524050
32CDK71.24529373
33MAP3K31.22489516
34RIPK11.19672392
35CAMK41.18879593
36KSR21.18186305
37ALK1.17258763
38MARK21.15433472
39MAP3K111.13870149
40MOS1.11902438
41TBK11.11709046
42PAK41.10948137
43JAK31.10739478
44ADRBK21.10725984
45EPHA21.09998872
46CSK1.08828650
47MAP4K11.08251035
48CDC42BPA1.07960740
49PDGFRA1.06526703
50MTOR1.06350132
51MAP3K11.06119774
52HIPK21.05700506
53TESK21.04875536
54CDK41.04010104
55PRKG21.03288205
56PRKD21.02752055
57BTK1.02558938
58FES1.00825530
59ICK0.95539101
60CDC70.95524076
61SCYL20.90915145
62GRK70.90208242
63BMX0.88538980
64STK380.87012089
65SIK10.86666181
66PIM20.84020967
67RPS6KB20.83990762
68PDPK10.81652644
69NTRK10.81402952
70IRAK20.81184139
71JAK10.80661150
72BRD40.80638766
73CHEK20.78858080
74PDK30.77639734
75PDK40.77639734
76CHEK10.76225791
77ITK0.73478799
78AKT20.72980524
79FGFR40.70409351
80PLK10.69689614
81RAF10.69505512
82MAPK120.68889929
83EPHB10.68857544
84IKBKE0.68621105
85CLK10.68545143
86RPS6KC10.67911903
87RPS6KL10.67911903
88MAP2K40.67664300
89SIK30.64804017
90MELK0.63641246
91MKNK20.62172777
92FLT30.61768918
93ARAF0.61636075
94PTK60.61400563
95MAP3K80.59379358
96MST1R0.59256898
97SIK20.58935374
98DYRK1B0.58146779
99PTK20.57307719
100MAP3K60.54178705
101RPS6KA20.54069355
102BLK0.52806005
103MAP2K30.52319577
104SYK0.51174261
105CDK20.49867220
106MAP2K20.49791759
107LCK0.49571726
108MAPK110.49323100
109STK40.48821818
110CDK60.48438511
111HCK0.47368023
112PAK20.47358492
113TNK20.47277155
114RPS6KA60.45465492
115KDR0.44110073
116CAMKK10.43980452
117CAMK1D0.43886010
118FGR0.42585023
119WEE10.42044087
120RET0.40614742
121MAPKAPK30.40316741
122CDK80.39316601
123CAMK1G0.39279556
124LRRK20.39049169
125ATM0.38805772
126PRKAA20.38610745
127AURKB0.38462143
128TXK0.38340206
129JAK20.37809122
130MAPKAPK20.37605849
131PIM10.37494528
132TAOK10.36611379
133ERBB20.35990032
134MAP2K60.33768933
135ADRBK10.31875535
136MARK30.31094321
137PDGFRB0.31041255
138CHUK0.29811647
139ZAP700.29613933
140IGF1R0.29351832
141PRKAA10.28959966
142MAP3K90.28932802
143PRKD30.28838595
144PRKCI0.28604009
145NME20.28060645
146MAPK100.27792607
147MAPK10.27414065
148PDK10.27401673
149INSR0.26922757
150PRKD10.25924172

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.83855555
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.63416608
3One carbon pool by folate_Homo sapiens_hsa006702.42455002
4Other glycan degradation_Homo sapiens_hsa005112.42066027
5Fructose and mannose metabolism_Homo sapiens_hsa000512.41987284
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11951696
7Nitrogen metabolism_Homo sapiens_hsa009102.02757933
8Osteoclast differentiation_Homo sapiens_hsa043801.80160164
9Thyroid cancer_Homo sapiens_hsa052161.72872771
10Leishmaniasis_Homo sapiens_hsa051401.70849279
11Pancreatic cancer_Homo sapiens_hsa052121.69310093
12Lysine degradation_Homo sapiens_hsa003101.65508850
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62639213
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59675056
15Galactose metabolism_Homo sapiens_hsa000521.53096923
16mTOR signaling pathway_Homo sapiens_hsa041501.52883593
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52766112
18Measles_Homo sapiens_hsa051621.50616563
19Hepatitis B_Homo sapiens_hsa051611.46681255
20Arginine biosynthesis_Homo sapiens_hsa002201.44295627
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.44049487
22mRNA surveillance pathway_Homo sapiens_hsa030151.42070807
23Influenza A_Homo sapiens_hsa051641.39183098
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38262866
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36082329
26Toxoplasmosis_Homo sapiens_hsa051451.32918375
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27799283
28Acute myeloid leukemia_Homo sapiens_hsa052211.27640694
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27312506
30Endometrial cancer_Homo sapiens_hsa052131.26052490
31RNA transport_Homo sapiens_hsa030131.25856590
32Apoptosis_Homo sapiens_hsa042101.24733103
33Renal cell carcinoma_Homo sapiens_hsa052111.24018245
34TNF signaling pathway_Homo sapiens_hsa046681.21952711
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21832217
36Allograft rejection_Homo sapiens_hsa053301.20735557
37Pentose phosphate pathway_Homo sapiens_hsa000301.18391691
38Complement and coagulation cascades_Homo sapiens_hsa046101.17130343
39Viral myocarditis_Homo sapiens_hsa054161.16794990
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15718377
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.15334550
42Fanconi anemia pathway_Homo sapiens_hsa034601.15261899
43Graft-versus-host disease_Homo sapiens_hsa053321.11630204
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11214374
45Notch signaling pathway_Homo sapiens_hsa043301.10868629
46DNA replication_Homo sapiens_hsa030301.10804599
47Autoimmune thyroid disease_Homo sapiens_hsa053201.10616313
48Hepatitis C_Homo sapiens_hsa051601.10298620
49Basal cell carcinoma_Homo sapiens_hsa052171.09435607
50Tuberculosis_Homo sapiens_hsa051521.07475277
51Carbon metabolism_Homo sapiens_hsa012001.07474155
52Selenocompound metabolism_Homo sapiens_hsa004501.07428764
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07415751
54MicroRNAs in cancer_Homo sapiens_hsa052061.06994590
55Biosynthesis of amino acids_Homo sapiens_hsa012301.06652778
56Sulfur relay system_Homo sapiens_hsa041221.06569724
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05634234
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02907048
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02403919
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00601982
61PPAR signaling pathway_Homo sapiens_hsa033200.99631244
62Colorectal cancer_Homo sapiens_hsa052100.99366143
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.98967178
64Small cell lung cancer_Homo sapiens_hsa052220.98561433
65Tryptophan metabolism_Homo sapiens_hsa003800.98215968
66Glioma_Homo sapiens_hsa052140.98147083
67Antigen processing and presentation_Homo sapiens_hsa046120.97791068
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.97568801
69Prostate cancer_Homo sapiens_hsa052150.95403053
70Non-small cell lung cancer_Homo sapiens_hsa052230.93732270
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93450537
72Epstein-Barr virus infection_Homo sapiens_hsa051690.93371591
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93200336
74AMPK signaling pathway_Homo sapiens_hsa041520.92165689
75Bladder cancer_Homo sapiens_hsa052190.91936709
76Insulin resistance_Homo sapiens_hsa049310.91619211
77Prolactin signaling pathway_Homo sapiens_hsa049170.91352474
78Prion diseases_Homo sapiens_hsa050200.90873015
79ErbB signaling pathway_Homo sapiens_hsa040120.90834109
80Bile secretion_Homo sapiens_hsa049760.90660565
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90453559
82Primary immunodeficiency_Homo sapiens_hsa053400.89494798
83B cell receptor signaling pathway_Homo sapiens_hsa046620.89068221
84Chemokine signaling pathway_Homo sapiens_hsa040620.83840468
85Shigellosis_Homo sapiens_hsa051310.83810097
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83690076
87Inositol phosphate metabolism_Homo sapiens_hsa005620.83411138
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83356458
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82781629
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82589083
91Staphylococcus aureus infection_Homo sapiens_hsa051500.82547663
92ABC transporters_Homo sapiens_hsa020100.81634849
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81568344
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.81264109
95Hematopoietic cell lineage_Homo sapiens_hsa046400.81223330
96Malaria_Homo sapiens_hsa051440.80684656
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.80596336
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79121110
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78115377
100Arachidonic acid metabolism_Homo sapiens_hsa005900.77649798
101Salmonella infection_Homo sapiens_hsa051320.77146552
102Systemic lupus erythematosus_Homo sapiens_hsa053220.77079904
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77064751
104VEGF signaling pathway_Homo sapiens_hsa043700.76297629
105Dorso-ventral axis formation_Homo sapiens_hsa043200.75797377
106Proteoglycans in cancer_Homo sapiens_hsa052050.74998733
107Glycerolipid metabolism_Homo sapiens_hsa005610.74098933
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73735261
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72848854
110GnRH signaling pathway_Homo sapiens_hsa049120.72600863
111HTLV-I infection_Homo sapiens_hsa051660.71980443
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71662972
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.71446659
114Cell cycle_Homo sapiens_hsa041100.71384966
115Pathways in cancer_Homo sapiens_hsa052000.71335861
116Legionellosis_Homo sapiens_hsa051340.70963962
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.70713304
118Amoebiasis_Homo sapiens_hsa051460.69938948
119Viral carcinogenesis_Homo sapiens_hsa052030.68988721
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67913412
121Homologous recombination_Homo sapiens_hsa034400.67306260
122FoxO signaling pathway_Homo sapiens_hsa040680.67264140
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67236387
124Lysosome_Homo sapiens_hsa041420.66415821
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65463912
126Chronic myeloid leukemia_Homo sapiens_hsa052200.64477746
127Rap1 signaling pathway_Homo sapiens_hsa040150.63634263
128Linoleic acid metabolism_Homo sapiens_hsa005910.63326273
129T cell receptor signaling pathway_Homo sapiens_hsa046600.61726965
130p53 signaling pathway_Homo sapiens_hsa041150.61211569
131Fatty acid degradation_Homo sapiens_hsa000710.61145319
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.60881175
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.60364316
134Platelet activation_Homo sapiens_hsa046110.59945524
135Herpes simplex infection_Homo sapiens_hsa051680.58882904
136Spliceosome_Homo sapiens_hsa030400.58624703
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58506926
138Chemical carcinogenesis_Homo sapiens_hsa052040.58183412
139Pertussis_Homo sapiens_hsa051330.56508625
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54390336
141Focal adhesion_Homo sapiens_hsa045100.53880661
142Endocytosis_Homo sapiens_hsa041440.53672202
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.51020937
144Adherens junction_Homo sapiens_hsa045200.50786563
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50150672
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50035549
147Hippo signaling pathway_Homo sapiens_hsa043900.48271950
148Choline metabolism in cancer_Homo sapiens_hsa052310.48076647
149Insulin signaling pathway_Homo sapiens_hsa049100.47632776
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47407823
151NF-kappa B signaling pathway_Homo sapiens_hsa040640.46825210
152HIF-1 signaling pathway_Homo sapiens_hsa040660.45598440
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.45137460
154Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45044576
155Glucagon signaling pathway_Homo sapiens_hsa049220.43840641

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