POLG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.77762841
2proteasome assembly (GO:0043248)5.26064275
3ribosomal small subunit biogenesis (GO:0042274)4.73564805
4telomere maintenance via semi-conservative replication (GO:0032201)4.67137783
5termination of RNA polymerase III transcription (GO:0006386)4.46206885
6transcription elongation from RNA polymerase III promoter (GO:0006385)4.46206885
7rRNA modification (GO:0000154)4.39783049
8maturation of SSU-rRNA (GO:0030490)4.32949403
9telomere maintenance via recombination (GO:0000722)4.16955328
10DNA double-strand break processing (GO:0000729)4.16580451
11ribosomal large subunit biogenesis (GO:0042273)4.14024514
12DNA strand elongation involved in DNA replication (GO:0006271)4.08998106
13regulation of nuclear cell cycle DNA replication (GO:0033262)3.99000449
14ribosomal small subunit assembly (GO:0000028)3.96456988
15DNA strand elongation (GO:0022616)3.93867371
16DNA damage response, detection of DNA damage (GO:0042769)3.84344349
17ribonucleoprotein complex biogenesis (GO:0022613)3.82394401
18ribosome assembly (GO:0042255)3.82135341
197-methylguanosine mRNA capping (GO:0006370)3.81778466
20deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.80185652
21RNA capping (GO:0036260)3.76982612
227-methylguanosine RNA capping (GO:0009452)3.76982612
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.76913994
24DNA replication initiation (GO:0006270)3.76555653
25replication fork processing (GO:0031297)3.75271302
26DNA catabolic process, exonucleolytic (GO:0000738)3.72543385
27mitotic recombination (GO:0006312)3.71512718
28deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.69702416
29synapsis (GO:0007129)3.67094923
30viral transcription (GO:0019083)3.66170637
31transcription-coupled nucleotide-excision repair (GO:0006283)3.65046264
32deoxyribonucleotide biosynthetic process (GO:0009263)3.64418249
33telomere maintenance via telomere lengthening (GO:0010833)3.62846690
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62328485
35DNA replication checkpoint (GO:0000076)3.60434148
36pseudouridine synthesis (GO:0001522)3.56465166
37CENP-A containing nucleosome assembly (GO:0034080)3.55700469
38IMP biosynthetic process (GO:0006188)3.53514169
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51850533
40translational termination (GO:0006415)3.51014839
41transcription from RNA polymerase I promoter (GO:0006360)3.49947230
42rRNA processing (GO:0006364)3.49577304
43DNA ligation (GO:0006266)3.48100532
44termination of RNA polymerase I transcription (GO:0006363)3.45575571
45spliceosomal snRNP assembly (GO:0000387)3.43486721
46mitochondrial RNA metabolic process (GO:0000959)3.42193502
47rRNA methylation (GO:0031167)3.40331892
48chromatin remodeling at centromere (GO:0031055)3.40115818
49ribosome biogenesis (GO:0042254)3.38542300
50rRNA metabolic process (GO:0016072)3.37697015
51tRNA methylation (GO:0030488)3.36922308
52regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36283273
53regulation of mitotic spindle checkpoint (GO:1903504)3.36283273
54RNA methylation (GO:0001510)3.34545616
55transcription elongation from RNA polymerase I promoter (GO:0006362)3.34233767
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33385578
57protein-cofactor linkage (GO:0018065)3.32760107
58L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31955081
59folic acid-containing compound biosynthetic process (GO:0009396)3.31333676
60positive regulation of histone H3-K4 methylation (GO:0051571)3.29812637
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28765805
62centriole replication (GO:0007099)3.27795133
63maturation of 5.8S rRNA (GO:0000460)3.26994323
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.26906515
65regulation of centriole replication (GO:0046599)3.26034833
66double-strand break repair via homologous recombination (GO:0000724)3.25295276
67recombinational repair (GO:0000725)3.25083954
68mitochondrial DNA replication (GO:0006264)3.24260762
69cellular component biogenesis (GO:0044085)3.23492534
70regulation of mitochondrial translation (GO:0070129)3.22877156
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.21300452
72regulation of double-strand break repair via homologous recombination (GO:0010569)3.19289760
73somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.18041764
74somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.18041764
75isotype switching (GO:0045190)3.18041764
76non-recombinational repair (GO:0000726)3.18007931
77double-strand break repair via nonhomologous end joining (GO:0006303)3.18007931
78cotranslational protein targeting to membrane (GO:0006613)3.16706323
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16559326
80kinetochore organization (GO:0051383)3.14780589
81respiratory chain complex IV assembly (GO:0008535)3.13502428
82protein targeting to ER (GO:0045047)3.12226881
83negative regulation of DNA-dependent DNA replication (GO:2000104)3.12169682
84translation (GO:0006412)3.11725441
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11607663
86reciprocal DNA recombination (GO:0035825)3.09795918
87reciprocal meiotic recombination (GO:0007131)3.09795918
88amino acid salvage (GO:0043102)3.09565156
89L-methionine salvage (GO:0071267)3.09565156
90L-methionine biosynthetic process (GO:0071265)3.09565156
91kinetochore assembly (GO:0051382)3.09294422
92histone exchange (GO:0043486)3.07716710
93centriole assembly (GO:0098534)3.07004365
94spliceosomal complex assembly (GO:0000245)3.06571142
95tRNA modification (GO:0006400)3.05906146
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03618554
97purine nucleobase biosynthetic process (GO:0009113)3.03199092
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02331405
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02331405
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02331405
101translational elongation (GO:0006414)3.01409488
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98179261
103mannosylation (GO:0097502)2.96923639
104nucleobase biosynthetic process (GO:0046112)2.96828463
105positive regulation of protein homodimerization activity (GO:0090073)2.96169307
106RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95976031
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95976031
108protein localization to endoplasmic reticulum (GO:0070972)2.95881117
109transcription initiation from RNA polymerase I promoter (GO:0006361)2.94441051
110regulation of cellular amino acid metabolic process (GO:0006521)2.93956529
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93892520
112positive regulation of granulocyte differentiation (GO:0030854)2.93563339
113establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93265284
114somatic hypermutation of immunoglobulin genes (GO:0016446)2.93049700
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93049700
116IMP metabolic process (GO:0046040)2.92139564
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.91009704
118signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91009704
119signal transduction involved in cell cycle checkpoint (GO:0072395)2.90959478
120histone H2A acetylation (GO:0043968)2.90919404
121DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90034379
122negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.89370930
123resolution of meiotic recombination intermediates (GO:0000712)2.89314104
124transcription elongation from RNA polymerase II promoter (GO:0006368)2.89136875
125attachment of spindle microtubules to kinetochore (GO:0008608)2.88903813
126translational initiation (GO:0006413)2.88873016
127* DNA-dependent DNA replication (GO:0006261)2.87374148
128nuclear pore organization (GO:0006999)2.87347917
129ncRNA processing (GO:0034470)2.86147440
130mitotic nuclear envelope disassembly (GO:0007077)2.86007933
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85444999
132negative regulation of ligase activity (GO:0051352)2.85444999
133signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84598054
134intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84598054
135peptidyl-histidine modification (GO:0018202)2.83390882
136DNA recombination (GO:0006310)2.82999761
137regulation of meiosis I (GO:0060631)2.81220070
138double-strand break repair (GO:0006302)2.81164230
139tRNA processing (GO:0008033)2.80106359
140RNA destabilization (GO:0050779)2.78573405
141negative regulation of mRNA processing (GO:0050686)2.78492933
142viral life cycle (GO:0019058)2.77950418
143ncRNA metabolic process (GO:0034660)2.77601241
144preassembly of GPI anchor in ER membrane (GO:0016254)2.77356544
145cullin deneddylation (GO:0010388)2.77228573
146DNA-templated transcription, termination (GO:0006353)2.77039377
147cytochrome complex assembly (GO:0017004)2.76914737
148regulation of helicase activity (GO:0051095)2.76870756
149mitotic sister chromatid segregation (GO:0000070)2.75857332
150positive regulation of histone methylation (GO:0031062)2.74986952
151protein deneddylation (GO:0000338)2.74639782
152transcription from mitochondrial promoter (GO:0006390)2.71856370
153DNA topological change (GO:0006265)2.71604004
154male meiosis I (GO:0007141)2.69493137
155somatic diversification of immunoglobulins (GO:0016445)2.69077602
156meiotic chromosome segregation (GO:0045132)2.68418856
157DNA methylation involved in gamete generation (GO:0043046)2.68192601
158negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67163276
159sister chromatid segregation (GO:0000819)2.67058847
160viral mRNA export from host cell nucleus (GO:0046784)2.66901518
161DNA replication-dependent nucleosome assembly (GO:0006335)2.66357899
162DNA replication-dependent nucleosome organization (GO:0034723)2.66357899
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65798536
164mitochondrial respiratory chain complex I assembly (GO:0032981)2.65798536
165NADH dehydrogenase complex assembly (GO:0010257)2.65798536
166negative regulation of mRNA metabolic process (GO:1903312)2.65484490
167nuclear pore complex assembly (GO:0051292)2.65297790
168tRNA metabolic process (GO:0006399)2.64954820
169somatic recombination of immunoglobulin gene segments (GO:0016447)2.64864166
170DNA replication-independent nucleosome organization (GO:0034724)2.64034393
171DNA replication-independent nucleosome assembly (GO:0006336)2.64034393
172somatic diversification of immune receptors (GO:0002200)2.62872063
173spindle checkpoint (GO:0031577)2.62229720
174termination of RNA polymerase II transcription (GO:0006369)2.60911985
175postreplication repair (GO:0006301)2.60883759
176regulation of centrosome cycle (GO:0046605)2.60223222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.84221446
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.68453452
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.97415491
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.96938753
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.91373025
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68788627
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.56584146
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.48432892
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.40348903
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.38163558
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22264401
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.12574558
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05485526
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89832163
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86908631
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82941923
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79059387
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74985586
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74659993
20* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72151157
21* VDR_23849224_ChIP-Seq_CD4+_Human2.61919094
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39183405
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35199553
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24391957
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.22503370
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.18282032
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09814203
28FOXP3_21729870_ChIP-Seq_TREG_Human2.09745591
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09566598
30ELK1_19687146_ChIP-ChIP_HELA_Human2.09497733
31* XRN2_22483619_ChIP-Seq_HELA_Human2.07550185
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.06389677
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03741920
34* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98733393
35TTF2_22483619_ChIP-Seq_HELA_Human1.94811259
36DCP1A_22483619_ChIP-Seq_HELA_Human1.94147142
37ZNF274_21170338_ChIP-Seq_K562_Hela1.92484647
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87075583
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86293686
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85887835
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78639175
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73918106
43FUS_26573619_Chip-Seq_HEK293_Human1.71203074
44* EWS_26573619_Chip-Seq_HEK293_Human1.66994728
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65630504
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64015187
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63236068
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59095324
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58646477
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58646477
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58646477
52* NOTCH1_21737748_ChIP-Seq_TLL_Human1.58439201
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.57372169
54* GABP_19822575_ChIP-Seq_HepG2_Human1.56421031
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53942032
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53182272
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52798468
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51742325
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.44717282
60IRF1_19129219_ChIP-ChIP_H3396_Human1.43748800
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40558360
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.36982212
63* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36693884
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33825796
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29713961
66MYC_18940864_ChIP-ChIP_HL60_Human1.27257501
67VDR_22108803_ChIP-Seq_LS180_Human1.23957202
68CIITA_25753668_ChIP-Seq_RAJI_Human1.23950626
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23911895
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22426309
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21384351
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.20941327
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17127772
74* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15799971
75* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15343754
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12677883
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09971561
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09550468
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06928973
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04903970
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.04203523
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04166843
83TP53_22573176_ChIP-Seq_HFKS_Human1.03796294
84AR_21909140_ChIP-Seq_LNCAP_Human1.02402946
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02338667
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98531629
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97571058
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97478936
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96596633
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96247826
91MYB_26560356_Chip-Seq_TH2_Human0.95900633
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94837337
93IGF1R_20145208_ChIP-Seq_DFB_Human0.93631313
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93578842
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91661830
96KDM5A_27292631_Chip-Seq_BREAST_Human0.89079586
97SPI1_23547873_ChIP-Seq_NB4_Human0.88371986
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.88316371
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88179211
100TFEB_21752829_ChIP-Seq_HELA_Human0.87210263
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85878843
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.84935800
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84231423
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82657824
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82107441
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82057055
107ER_23166858_ChIP-Seq_MCF-7_Human0.81258590
108MYB_26560356_Chip-Seq_TH1_Human0.81146181
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80518957
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79621629
111* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77604911
112NFE2_27457419_Chip-Seq_LIVER_Mouse0.76933040
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76019222
114GATA3_26560356_Chip-Seq_TH2_Human0.75237754
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.72999688
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72449463
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71894572
118CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71166096
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70189418
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.69740199
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69227661
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.69041508
123* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68876367
124* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.68780293
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.68254425
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.68192976
127GATA3_26560356_Chip-Seq_TH1_Human0.67728814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.64284410
2MP0001986_abnormal_taste_sensitivity3.52911204
3MP0008058_abnormal_DNA_repair3.36328565
4MP0008057_abnormal_DNA_replication3.29737611
5MP0009379_abnormal_foot_pigmentation3.23102286
6MP0006292_abnormal_olfactory_placode2.91612664
7MP0003111_abnormal_nucleus_morphology2.82810041
8MP0000566_synostosis2.81876635
9MP0010094_abnormal_chromosome_stability2.77783473
10MP0003136_yellow_coat_color2.77777946
11MP0005409_darkened_coat_color2.76377064
12MP0008007_abnormal_cellular_replicative2.57577430
13MP0003718_maternal_effect2.56312928
14MP0003077_abnormal_cell_cycle2.39591807
15MP0004957_abnormal_blastocyst_morpholog2.36774748
16MP0004381_abnormal_hair_follicle2.34713808
17MP0001188_hyperpigmentation2.27164053
18MP0002277_abnormal_respiratory_mucosa2.16421936
19MP0008932_abnormal_embryonic_tissue2.09237091
20MP0003786_premature_aging2.01098853
21MP0005075_abnormal_melanosome_morpholog1.88770175
22MP0002160_abnormal_reproductive_system1.82623238
23MP0000372_irregular_coat_pigmentation1.77570970
24MP0003941_abnormal_skin_development1.77217184
25MP0002132_abnormal_respiratory_system1.73646238
26MP0003890_abnormal_embryonic-extraembry1.67498293
27MP0003806_abnormal_nucleotide_metabolis1.62710759
28MP0003763_abnormal_thymus_physiology1.61714602
29MP0006035_abnormal_mitochondrial_morpho1.58181461
30MP0000015_abnormal_ear_pigmentation1.57404317
31MP0008260_abnormal_autophagy1.53536364
32MP0006036_abnormal_mitochondrial_physio1.47201550
33MP0008877_abnormal_DNA_methylation1.46272488
34MP0005389_reproductive_system_phenotype1.46139015
35MP0002148_abnormal_hypersensitivity_rea1.43523587
36MP0002102_abnormal_ear_morphology1.40899953
37MP0000490_abnormal_crypts_of1.38090449
38MP0001853_heart_inflammation1.37207577
39MP0006072_abnormal_retinal_apoptosis1.37135139
40MP0009333_abnormal_splenocyte_physiolog1.32576393
41MP0003567_abnormal_fetal_cardiomyocyte1.31781179
42MP0005084_abnormal_gallbladder_morpholo1.30474057
43MP0010307_abnormal_tumor_latency1.29063528
44MP0002928_abnormal_bile_duct1.29028709
45MP0005174_abnormal_tail_pigmentation1.28676881
46MP0001293_anophthalmia1.25983601
47MP0008789_abnormal_olfactory_epithelium1.25306511
48MP0004133_heterotaxia1.24708706
49MP0003724_increased_susceptibility_to1.24206438
50MP0003878_abnormal_ear_physiology1.22789094
51MP0005377_hearing/vestibular/ear_phenot1.22789094
52MP0002210_abnormal_sex_determination1.19303486
53MP0002163_abnormal_gland_morphology1.19129703
54MP0005171_absent_coat_pigmentation1.18637056
55MP0003698_abnormal_male_reproductive1.17601945
56MP0001697_abnormal_embryo_size1.16342077
57MP0000613_abnormal_salivary_gland1.15830728
58MP0005423_abnormal_somatic_nervous1.14219764
59MP0005367_renal/urinary_system_phenotyp1.13956015
60MP0000516_abnormal_urinary_system1.13956015
61MP0001730_embryonic_growth_arrest1.13489143
62MP0002095_abnormal_skin_pigmentation1.13128203
63MP0004808_abnormal_hematopoietic_stem1.12513858
64MP0001919_abnormal_reproductive_system1.09245540
65MP0002009_preneoplasia1.08425672
66MP0000358_abnormal_cell_content/1.06688945
67MP0005253_abnormal_eye_physiology1.06062758
68MP0004147_increased_porphyrin_level1.05949863
69MP0003950_abnormal_plasma_membrane1.04744542
70MP0003186_abnormal_redox_activity1.04185513
71MP0001672_abnormal_embryogenesis/_devel1.03992696
72MP0005380_embryogenesis_phenotype1.03992696
73MP0002876_abnormal_thyroid_physiology1.03902352
74MP0003943_abnormal_hepatobiliary_system1.02901757
75MP0004197_abnormal_fetal_growth/weight/1.02562675
76MP0003984_embryonic_growth_retardation1.01384335
77MP0002088_abnormal_embryonic_growth/wei1.01303667
78MP0009785_altered_susceptibility_to0.99843248
79MP0002396_abnormal_hematopoietic_system0.99273735
80MP0005395_other_phenotype0.98033229
81MP0001145_abnormal_male_reproductive0.97596758
82MP0005000_abnormal_immune_tolerance0.96584844
83MP0001764_abnormal_homeostasis0.96130469
84MP0001119_abnormal_female_reproductive0.93527567
85MP0003121_genomic_imprinting0.93085104
86MP0001661_extended_life_span0.91170708
87MP0001186_pigmentation_phenotype0.89841038
88MP0005083_abnormal_biliary_tract0.89603963
89MP0000313_abnormal_cell_death0.89304155
90MP0000653_abnormal_sex_gland0.89232312
91MP0005671_abnormal_response_to0.89213053
92MP0004142_abnormal_muscle_tone0.88952836
93MP0003787_abnormal_imprinting0.88779317
94MP0005646_abnormal_pituitary_gland0.87489389
95MP0001929_abnormal_gametogenesis0.86032561
96MP0002080_prenatal_lethality0.85712997
97MP0003938_abnormal_ear_development0.85286475
98MP0000678_abnormal_parathyroid_gland0.84810891
99MP0000631_abnormal_neuroendocrine_gland0.84729928
100MP0003315_abnormal_perineum_morphology0.84560338
101MP0000703_abnormal_thymus_morphology0.83890073
102MP0002638_abnormal_pupillary_reflex0.82348675
103MP0000689_abnormal_spleen_morphology0.81845557
104MP0002722_abnormal_immune_system0.81750123
105MP0003195_calcinosis0.81404719
106MP0002751_abnormal_autonomic_nervous0.79860126
107MP0002938_white_spotting0.79406915
108MP0002723_abnormal_immune_serum0.78213171
109MP0001835_abnormal_antigen_presentation0.77424383
110MP0002420_abnormal_adaptive_immunity0.77326241
111MP0001800_abnormal_humoral_immune0.77271912
112MP0008872_abnormal_physiological_respon0.77242910
113MP0001905_abnormal_dopamine_level0.77229789
114MP0000350_abnormal_cell_proliferation0.77196836
115MP0005499_abnormal_olfactory_system0.77049169
116MP0005394_taste/olfaction_phenotype0.77049169
117MP0001819_abnormal_immune_cell0.76887741
118MP0009697_abnormal_copulation0.76635214
119MP0009765_abnormal_xenobiotic_induced0.75915855
120MP0005025_abnormal_response_to0.75864591
121MP0002452_abnormal_antigen_presenting0.75432254
122MP0002084_abnormal_developmental_patter0.74299752
123MP0003656_abnormal_erythrocyte_physiolo0.73858818
124MP0000858_altered_metastatic_potential0.73267741
125MP0002019_abnormal_tumor_incidence0.72878231
126MP0002429_abnormal_blood_cell0.72737031
127MP0009703_decreased_birth_body0.72716240
128MP0003699_abnormal_female_reproductive0.72499124
129MP0005391_vision/eye_phenotype0.72409439
130MP0005408_hypopigmentation0.71990140
131MP0005551_abnormal_eye_electrophysiolog0.71809447
132MP0002075_abnormal_coat/hair_pigmentati0.71423656
133MP0001545_abnormal_hematopoietic_system0.70140990
134MP0005397_hematopoietic_system_phenotyp0.70140990
135MP0002398_abnormal_bone_marrow0.70119864
136MP0000716_abnormal_immune_system0.69008333
137MP0008873_increased_physiological_sensi0.68901777
138MP0003221_abnormal_cardiomyocyte_apopto0.68733477
139MP0002419_abnormal_innate_immunity0.68285771
140MP0001286_abnormal_eye_development0.68275414
141MP0008995_early_reproductive_senescence0.66975065
142MP0001324_abnormal_eye_pigmentation0.66888021
143MP0002086_abnormal_extraembryonic_tissu0.66862645
144MP0001485_abnormal_pinna_reflex0.66127285
145MP0003011_delayed_dark_adaptation0.65941876
146MP0002161_abnormal_fertility/fecundity0.65623808
147MP0001542_abnormal_bone_strength0.65484607
148MP0005379_endocrine/exocrine_gland_phen0.65382883

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.37128598
2Birth length less than 3rd percentile (HP:0003561)4.15103359
3Duplicated collecting system (HP:0000081)4.02943166
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84167353
5Abnormality of the renal collecting system (HP:0004742)3.72885524
6Reticulocytopenia (HP:0001896)3.67459438
7Chromsome breakage (HP:0040012)3.64864865
8Type I transferrin isoform profile (HP:0003642)3.44731637
93-Methylglutaconic aciduria (HP:0003535)3.39497762
10* Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.20370079
11Granulocytopenia (HP:0001913)3.07637539
12Cerebral hypomyelination (HP:0006808)3.00043199
13Macrocytic anemia (HP:0001972)2.93687979
14Colon cancer (HP:0003003)2.80201044
15Abnormality of cells of the erythroid lineage (HP:0012130)2.75312591
16Abnormal number of erythroid precursors (HP:0012131)2.73082334
17Abnormality of alanine metabolism (HP:0010916)2.70783177
18Hyperalaninemia (HP:0003348)2.70783177
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70783177
20Abnormality of the preputium (HP:0100587)2.70347102
21Meckel diverticulum (HP:0002245)2.68906142
22Tubulointerstitial nephritis (HP:0001970)2.66793743
23Renal Fanconi syndrome (HP:0001994)2.63720714
24Myelodysplasia (HP:0002863)2.63150901
25Reduced antithrombin III activity (HP:0001976)2.60117069
26Volvulus (HP:0002580)2.60032234
27Rough bone trabeculation (HP:0100670)2.58059329
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57246685
29Carpal bone hypoplasia (HP:0001498)2.55927229
30Sloping forehead (HP:0000340)2.53579638
31Abnormality of the ileum (HP:0001549)2.53542570
32Congenital stationary night blindness (HP:0007642)2.52663731
33Aplasia/hypoplasia of the uterus (HP:0008684)2.49740191
34Increased hepatocellular lipid droplets (HP:0006565)2.44949537
35Hepatocellular necrosis (HP:0001404)2.44827701
36Mitochondrial inheritance (HP:0001427)2.40077138
37Medial flaring of the eyebrow (HP:0010747)2.39882915
38Methylmalonic acidemia (HP:0002912)2.37824764
39Microvesicular hepatic steatosis (HP:0001414)2.37598776
40Stomach cancer (HP:0012126)2.36613387
41Hyperglycinemia (HP:0002154)2.35310815
42Type 2 muscle fiber atrophy (HP:0003554)2.33228641
43Abnormal protein N-linked glycosylation (HP:0012347)2.32229879
44Abnormal protein glycosylation (HP:0012346)2.32229879
45Abnormal glycosylation (HP:0012345)2.32229879
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32229879
47Attenuation of retinal blood vessels (HP:0007843)2.31046200
48Prolonged neonatal jaundice (HP:0006579)2.30854273
49Pallor (HP:0000980)2.30187664
50Absent radius (HP:0003974)2.27995632
51Triphalangeal thumb (HP:0001199)2.27805341
52Abnormality of the duodenum (HP:0002246)2.27296331
53Acute necrotizing encephalopathy (HP:0006965)2.26780284
54Pancreatic cysts (HP:0001737)2.24733153
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.24586827
56Abnormality of chromosome stability (HP:0003220)2.23738669
57Abnormality of DNA repair (HP:0003254)2.23561865
58Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23378729
59Clubbing of toes (HP:0100760)2.23180778
60* Increased serum lactate (HP:0002151)2.22207462
61Exertional dyspnea (HP:0002875)2.22149465
62Abnormality of the labia minora (HP:0012880)2.20348979
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19725730
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19725730
65Eosinophilia (HP:0001880)2.19468396
66Conical tooth (HP:0000698)2.18493905
67Abnormality of B cell number (HP:0010975)2.18229258
68Aplasia/Hypoplasia of the earlobes (HP:0009906)2.17953304
69Parakeratosis (HP:0001036)2.16783714
70Aplasia involving forearm bones (HP:0009822)2.14867152
71Absent forearm bone (HP:0003953)2.14867152
72Abnormal trabecular bone morphology (HP:0100671)2.14520119
73Acute encephalopathy (HP:0006846)2.13243235
74Aplastic anemia (HP:0001915)2.12961797
75Increased CSF lactate (HP:0002490)2.12900541
76Bone marrow hypocellularity (HP:0005528)2.11929374
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11797283
78B lymphocytopenia (HP:0010976)2.11345266
79Abnormality of serum amino acid levels (HP:0003112)2.10956867
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09929728
81Oral leukoplakia (HP:0002745)2.09322277
82Renal cortical cysts (HP:0000803)2.07391581
83* Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07360404
84Intestinal atresia (HP:0011100)2.06824921
85Hepatic necrosis (HP:0002605)2.05569374
86Patellar aplasia (HP:0006443)2.04802471
87Muscle fiber atrophy (HP:0100295)2.04790698
88Nephroblastoma (Wilms tumor) (HP:0002667)2.04442680
89Aplasia/Hypoplasia of the spleen (HP:0010451)2.03449114
90Premature graying of hair (HP:0002216)2.02175999
91Abnormality of renal resorption (HP:0011038)2.01126074
92Pancytopenia (HP:0001876)2.00728145
93Congenital primary aphakia (HP:0007707)2.00563645
94Abnormality of the renal cortex (HP:0011035)2.00038497
95Severe visual impairment (HP:0001141)1.99592957
96Absent thumb (HP:0009777)1.99573123
97Abnormality of methionine metabolism (HP:0010901)1.98282662
98True hermaphroditism (HP:0010459)1.98148585
99Aplasia/Hypoplasia of the patella (HP:0006498)1.98004005
100Nephrogenic diabetes insipidus (HP:0009806)1.96430196
101Asplenia (HP:0001746)1.96157055
102Septo-optic dysplasia (HP:0100842)1.96134286
103Methylmalonic aciduria (HP:0012120)1.95673991
104Progressive macrocephaly (HP:0004481)1.95439530
105* Progressive external ophthalmoplegia (HP:0000590)1.95288137
106Lipid accumulation in hepatocytes (HP:0006561)1.94679690
107Abnormal lung lobation (HP:0002101)1.94675143
108Horseshoe kidney (HP:0000085)1.94617770
109Embryonal renal neoplasm (HP:0011794)1.94591135
110Abnormality of the pons (HP:0007361)1.94292425
111Supernumerary spleens (HP:0009799)1.93942721
112Abnormality of homocysteine metabolism (HP:0010919)1.92929170
113Homocystinuria (HP:0002156)1.92929170
114Acute lymphatic leukemia (HP:0006721)1.92361640
115Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90751606
116Astigmatism (HP:0000483)1.88840140
117Microretrognathia (HP:0000308)1.87986883
118Proximal tubulopathy (HP:0000114)1.87289900
119Adrenal hypoplasia (HP:0000835)1.86827793
120Severe combined immunodeficiency (HP:0004430)1.86696752
121Molar tooth sign on MRI (HP:0002419)1.86676635
122Abnormality of midbrain morphology (HP:0002418)1.86676635
123Abnormality of eosinophils (HP:0001879)1.86536002
124Hypoplasia of the pons (HP:0012110)1.85572448
125Ependymoma (HP:0002888)1.84465750
126Panhypogammaglobulinemia (HP:0003139)1.84210998
127Neutropenia (HP:0001875)1.82815060
128Sparse eyelashes (HP:0000653)1.82775849
129Impulsivity (HP:0100710)1.82753603
130Duodenal stenosis (HP:0100867)1.81501207
131Small intestinal stenosis (HP:0012848)1.81501207
132Abnormal mitochondria in muscle tissue (HP:0008316)1.80684345
133Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79823146
134Abnormal biliary tract physiology (HP:0012439)1.79723997
135Bile duct proliferation (HP:0001408)1.79723997
136Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79168870
137Ectopic kidney (HP:0000086)1.79031713
138Optic disc pallor (HP:0000543)1.78901239
139Pancreatic fibrosis (HP:0100732)1.78559728
140Ureteral duplication (HP:0000073)1.78488287
141Pulmonary artery stenosis (HP:0004415)1.76724431
142Gait imbalance (HP:0002141)1.76233273
143Lactic acidosis (HP:0003128)1.75142824
144Abnormality of placental membranes (HP:0011409)1.74008349
145Amniotic constriction ring (HP:0009775)1.74008349
146Abnormality of glycine metabolism (HP:0010895)1.72152837
147Abnormality of serine family amino acid metabolism (HP:0010894)1.72152837
148Neoplasm of the adrenal cortex (HP:0100641)1.71981065
149Cerebellar dysplasia (HP:0007033)1.71733900
150Cerebral edema (HP:0002181)1.71659959
151Pancreatic islet-cell hyperplasia (HP:0004510)1.70177958
152Abnormality of the carotid arteries (HP:0005344)1.68615965
153Pendular nystagmus (HP:0012043)1.68311949
154Poor coordination (HP:0002370)1.68012173
155Chronic hepatic failure (HP:0100626)1.67899065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.45418384
2PLK44.13092129
3STK164.00688720
4BUB13.74431683
5IRAK43.43299777
6ZAK3.21207206
7TAOK32.95246978
8IRAK22.82231301
9FRK2.59447275
10IRAK12.45943450
11SRPK12.41932314
12EIF2AK12.29411164
13WEE12.20512061
14VRK22.17064279
15MARK12.13620185
16CDK122.03623878
17TAF11.99092862
18TRIM281.98829959
19TLK11.88433950
20EIF2AK31.87389567
21VRK11.87209874
22MKNK11.81560200
23TSSK61.78558113
24TNIK1.73104788
25PDK21.66144241
26TIE11.61406103
27MKNK21.52946751
28SIK31.50690710
29TTK1.50064602
30NME21.47590871
31WNK31.42282200
32TESK21.36273458
33NLK1.36147624
34PBK1.34873893
35DYRK31.29885795
36EPHA21.29024174
37MAP4K21.25923231
38CASK1.25005709
39EIF2AK21.24505748
40NEK11.24269184
41TEC1.20731277
42FLT31.20135713
43CCNB11.13875128
44BMPR1B1.12428735
45TXK1.09478392
46PASK1.07139733
47CDC71.04118163
48AKT31.03570416
49PLK31.02871079
50YES11.00224593
51CLK10.99920566
52NME10.98365555
53PLK10.96968604
54DYRK20.94399856
55NEK60.91735418
56GRK10.90687712
57MARK30.88946746
58ATR0.85963132
59IKBKB0.80861190
60PRKCI0.78194967
61PIM20.76286133
62STK100.75654943
63BMPR20.75489820
64PNCK0.74445227
65MAP2K60.74325965
66CDK70.74183637
67RPS6KA50.73990435
68WNK40.72647403
69MAP3K40.71347133
70KDR0.70970465
71CHEK20.70342192
72CDK90.69776391
73CDK30.69332048
74STK390.68469902
75NEK20.67747367
76STK38L0.66071141
77ADRBK20.64651052
78AURKA0.62843491
79BRSK20.62540231
80MST40.62485897
81TGFBR10.61993081
82TNK20.60856329
83CSNK1G10.59316701
84AURKB0.57740292
85MAPKAPK50.55019958
86STK40.54319967
87ACVR1B0.54058140
88RPS6KB20.53607214
89MAP3K140.53039282
90CDK40.50578799
91CSNK1A1L0.49871218
92BLK0.49720861
93CSNK2A10.49645749
94STK30.49097700
95PRPF4B0.49026091
96OXSR10.48803676
97MUSK0.48779096
98BRAF0.48432142
99CSNK1G30.46195363
100KIT0.45892045
101MAPK70.45762067
102BRD40.45306351
103CDK60.44731833
104PLK20.43936580
105CDK20.43762681
106ABL20.43485587
107BTK0.41758416
108GRK70.41229716
109RPS6KA40.41041825
110CDK10.40813796
111CSNK2A20.39284191
112JAK30.39124915
113CDK80.37949956
114NUAK10.37582592
115IKBKE0.37229408
116MAPK130.36849270
117CAMK2B0.36724335
118FGFR10.36710932
119CHEK10.36021006
120BCKDK0.35851158
121PKN10.33663651
122ITK0.33355421
123FES0.33202027
124GRK60.32731225
125MAPK40.32722849
126ATM0.32598335
127PIM10.31903977
128CSNK1G20.31804930
129PINK10.31480888
130PRKCQ0.31261507
131LYN0.30949864
132MAP2K20.30794470
133FGR0.30775125
134INSRR0.30293380
135DYRK1A0.29937849
136CAMK2D0.29575572
137RAF10.29137628
138PRKD20.29074889
139MAP3K110.28672557
140MELK0.28196335
141ERBB30.27241804
142TYK20.27115648
143CAMK2G0.26838623
144PAK10.25213278
145MAP4K10.23651515
146BRSK10.23274852

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.12064673
2RNA polymerase_Homo sapiens_hsa030204.07559436
3DNA replication_Homo sapiens_hsa030304.06947106
4Proteasome_Homo sapiens_hsa030503.56155632
5Mismatch repair_Homo sapiens_hsa034303.42810034
6Homologous recombination_Homo sapiens_hsa034403.07220431
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94572522
8Pyrimidine metabolism_Homo sapiens_hsa002402.81182428
9Fanconi anemia pathway_Homo sapiens_hsa034602.78372584
10Spliceosome_Homo sapiens_hsa030402.68782917
11Nucleotide excision repair_Homo sapiens_hsa034202.36665077
12Base excision repair_Homo sapiens_hsa034102.30969722
13Basal transcription factors_Homo sapiens_hsa030222.13924093
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09105846
15Propanoate metabolism_Homo sapiens_hsa006401.99242125
16Non-homologous end-joining_Homo sapiens_hsa034501.87086149
17Selenocompound metabolism_Homo sapiens_hsa004501.78798458
18RNA transport_Homo sapiens_hsa030131.78465558
19One carbon pool by folate_Homo sapiens_hsa006701.77325897
20Protein export_Homo sapiens_hsa030601.75324760
21Purine metabolism_Homo sapiens_hsa002301.74522643
22Oxidative phosphorylation_Homo sapiens_hsa001901.72173376
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64857617
24RNA degradation_Homo sapiens_hsa030181.64806474
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63573774
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59540863
27Cell cycle_Homo sapiens_hsa041101.48643157
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43021787
29Phototransduction_Homo sapiens_hsa047441.40434500
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38863045
31Huntingtons disease_Homo sapiens_hsa050161.35699962
32Parkinsons disease_Homo sapiens_hsa050121.35038513
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30516508
34p53 signaling pathway_Homo sapiens_hsa041151.22485258
35Arachidonic acid metabolism_Homo sapiens_hsa005901.22410162
36Butanoate metabolism_Homo sapiens_hsa006501.22400301
37Folate biosynthesis_Homo sapiens_hsa007901.17240514
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14447339
39Epstein-Barr virus infection_Homo sapiens_hsa051691.10214927
40Primary immunodeficiency_Homo sapiens_hsa053401.08145761
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02037630
42Vitamin B6 metabolism_Homo sapiens_hsa007501.01881294
43Glutathione metabolism_Homo sapiens_hsa004800.97841229
44Sphingolipid metabolism_Homo sapiens_hsa006000.94030184
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93979863
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.91851165
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90760925
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.89349474
49Linoleic acid metabolism_Homo sapiens_hsa005910.89328435
50Ether lipid metabolism_Homo sapiens_hsa005650.88625366
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87301129
52Alzheimers disease_Homo sapiens_hsa050100.83033652
53Other glycan degradation_Homo sapiens_hsa005110.78781239
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78377077
55Peroxisome_Homo sapiens_hsa041460.77298847
56Pyruvate metabolism_Homo sapiens_hsa006200.77113148
57Herpes simplex infection_Homo sapiens_hsa051680.74816136
58Sulfur relay system_Homo sapiens_hsa041220.74014757
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72164958
60Oocyte meiosis_Homo sapiens_hsa041140.72100615
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71419922
62Fatty acid metabolism_Homo sapiens_hsa012120.70796529
63Asthma_Homo sapiens_hsa053100.68837622
64mRNA surveillance pathway_Homo sapiens_hsa030150.68151592
65Steroid biosynthesis_Homo sapiens_hsa001000.66219048
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64558822
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.63268050
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.62205952
69Systemic lupus erythematosus_Homo sapiens_hsa053220.60635525
70* Metabolic pathways_Homo sapiens_hsa011000.60234660
71Graft-versus-host disease_Homo sapiens_hsa053320.59794792
72Allograft rejection_Homo sapiens_hsa053300.59152775
73Lysine degradation_Homo sapiens_hsa003100.57826811
74Pentose phosphate pathway_Homo sapiens_hsa000300.57691063
75Autoimmune thyroid disease_Homo sapiens_hsa053200.57577760
76Measles_Homo sapiens_hsa051620.53668335
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52366200
78Caffeine metabolism_Homo sapiens_hsa002320.50072839
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.49793297
80Retinol metabolism_Homo sapiens_hsa008300.48165725
81Nitrogen metabolism_Homo sapiens_hsa009100.47703373
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47668330
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46590766
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46499733
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.46218762
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45879837
87Fatty acid elongation_Homo sapiens_hsa000620.45019156
88Regulation of autophagy_Homo sapiens_hsa041400.44883084
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44456215
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43921336
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43639093
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42345440
93Carbon metabolism_Homo sapiens_hsa012000.41599566
94Fatty acid biosynthesis_Homo sapiens_hsa000610.41525459
95Arginine and proline metabolism_Homo sapiens_hsa003300.41463106
96Biosynthesis of amino acids_Homo sapiens_hsa012300.39779106
97Vitamin digestion and absorption_Homo sapiens_hsa049770.39340283
98Antigen processing and presentation_Homo sapiens_hsa046120.38851477
99Hematopoietic cell lineage_Homo sapiens_hsa046400.35559952
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34752804
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34307221
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31853634
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31146988
104Rheumatoid arthritis_Homo sapiens_hsa053230.30482264
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.29396083
106Olfactory transduction_Homo sapiens_hsa047400.28431236
107Viral carcinogenesis_Homo sapiens_hsa052030.27722648
108Histidine metabolism_Homo sapiens_hsa003400.27381447
109Legionellosis_Homo sapiens_hsa051340.26029343
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25143884
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23589766
112Fatty acid degradation_Homo sapiens_hsa000710.22566571
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20035504
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.19906147
115HTLV-I infection_Homo sapiens_hsa051660.19461329
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19294040
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18196475
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17950183
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17838897
120Apoptosis_Homo sapiens_hsa042100.16115404
121Circadian rhythm_Homo sapiens_hsa047100.15083557
122Taste transduction_Homo sapiens_hsa047420.14163606
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14093589
124ABC transporters_Homo sapiens_hsa020100.12718202
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12693163
126Sulfur metabolism_Homo sapiens_hsa009200.12517595
127Influenza A_Homo sapiens_hsa051640.12382217
128Thyroid cancer_Homo sapiens_hsa052160.12301341
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.11849585
130Chemical carcinogenesis_Homo sapiens_hsa052040.11805196
131N-Glycan biosynthesis_Homo sapiens_hsa005100.11596985
132Leishmaniasis_Homo sapiens_hsa051400.11558575

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