POLH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.41980876
2DNA unwinding involved in DNA replication (GO:0006268)5.34037398
3nuclear pore complex assembly (GO:0051292)5.00681524
4nuclear pore organization (GO:0006999)4.91130994
5protein localization to chromosome, centromeric region (GO:0071459)4.82161372
6mitotic chromosome condensation (GO:0007076)4.44665752
7sister chromatid segregation (GO:0000819)4.40646303
8folic acid-containing compound biosynthetic process (GO:0009396)4.35119704
9mitotic sister chromatid cohesion (GO:0007064)4.18295115
10regulation of centriole replication (GO:0046599)4.18240732
11mitotic nuclear envelope disassembly (GO:0007077)4.17068559
12mitotic sister chromatid segregation (GO:0000070)4.03810413
13IMP biosynthetic process (GO:0006188)3.98702897
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.93310574
15pore complex assembly (GO:0046931)3.92947099
16nuclear envelope disassembly (GO:0051081)3.90777637
17membrane disassembly (GO:0030397)3.90777637
18regulation of spindle organization (GO:0090224)3.86929361
19DNA strand elongation involved in DNA replication (GO:0006271)3.86302009
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.83758746
21DNA replication initiation (GO:0006270)3.79921339
22DNA replication-dependent nucleosome organization (GO:0034723)3.71460055
23DNA replication-dependent nucleosome assembly (GO:0006335)3.71460055
24DNA strand elongation (GO:0022616)3.70585022
25DNA duplex unwinding (GO:0032508)3.58124178
26DNA geometric change (GO:0032392)3.56834026
27IMP metabolic process (GO:0046040)3.52748241
28regulation of translation in response to stress (GO:0043555)3.47742958
29attachment of spindle microtubules to kinetochore (GO:0008608)3.46617825
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.44791038
31translesion synthesis (GO:0019985)3.44718927
32telomere maintenance via semi-conservative replication (GO:0032201)3.44623823
33DNA topological change (GO:0006265)3.43701002
34regulation of histone H3-K9 methylation (GO:0051570)3.42197346
35positive regulation of chromosome segregation (GO:0051984)3.40068527
36regulation of centrosome duplication (GO:0010824)3.39985317
37protein K6-linked ubiquitination (GO:0085020)3.38295360
38mitotic recombination (GO:0006312)3.37426693
39regulation of translational fidelity (GO:0006450)3.33956998
40ER overload response (GO:0006983)3.31818329
41chromatin assembly (GO:0031497)3.30559351
42protein localization to chromosome (GO:0034502)3.29543017
43chromosome condensation (GO:0030261)3.23356333
44histone-serine phosphorylation (GO:0035404)3.21088666
45regulation of RNA export from nucleus (GO:0046831)3.21067155
46telomere maintenance via recombination (GO:0000722)3.19207245
47regulation of mitotic spindle organization (GO:0060236)3.17863630
48nuclear envelope organization (GO:0006998)3.15246402
49chromatin assembly or disassembly (GO:0006333)3.15167968
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.13022688
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.13022688
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.13022688
53kinetochore organization (GO:0051383)3.11232071
54rRNA methylation (GO:0031167)3.10947904
55DNA conformation change (GO:0071103)3.09928834
56dosage compensation (GO:0007549)2.98821050
57meiotic chromosome segregation (GO:0045132)2.97699576
58mitotic metaphase plate congression (GO:0007080)2.95163239
59wound healing, spreading of epidermal cells (GO:0035313)2.94313749
60rRNA modification (GO:0000154)2.93243410
61DNA packaging (GO:0006323)2.88101830
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87197716
63antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87197716
64regulation of DNA endoreduplication (GO:0032875)2.86983161
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86634425
66regulation of translational termination (GO:0006449)2.86595342
67DNA ligation (GO:0006266)2.86279850
68DNA replication-independent nucleosome organization (GO:0034724)2.86024273
69DNA replication-independent nucleosome assembly (GO:0006336)2.86024273
70DNA replication checkpoint (GO:0000076)2.85235682
71positive regulation of gamma-delta T cell activation (GO:0046645)2.83084218
72centriole replication (GO:0007099)2.82778176
73microtubule nucleation (GO:0007020)2.81914028
74CENP-A containing nucleosome assembly (GO:0034080)2.81284242
75negative regulation of histone methylation (GO:0031061)2.81264236
76spindle assembly (GO:0051225)2.79205707
77spindle organization (GO:0007051)2.79095085
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.78187757
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78187757
80chromatin remodeling at centromere (GO:0031055)2.76078037
81transcription-coupled nucleotide-excision repair (GO:0006283)2.74915428
82regulation of chromosome segregation (GO:0051983)2.73989454
83chromosome segregation (GO:0007059)2.72083970
84telomere maintenance via telomere lengthening (GO:0010833)2.71672410
85regulation of sister chromatid cohesion (GO:0007063)2.71556817
86recombinational repair (GO:0000725)2.71017879
87positive regulation of histone deacetylation (GO:0031065)2.71005002
88nucleotide-excision repair, DNA gap filling (GO:0006297)2.70540542
89mitochondrial DNA metabolic process (GO:0032042)2.70153550
90kinetochore assembly (GO:0051382)2.70051775
91replicative senescence (GO:0090399)2.69964608
92snRNA processing (GO:0016180)2.69952849
93monoubiquitinated protein deubiquitination (GO:0035520)2.69082016
94mRNA stabilization (GO:0048255)2.67736280
95RNA stabilization (GO:0043489)2.67736280
96double-strand break repair via homologous recombination (GO:0000724)2.67533024
97L-methionine salvage (GO:0071267)2.66824047
98L-methionine biosynthetic process (GO:0071265)2.66824047
99amino acid salvage (GO:0043102)2.66824047
100antigen processing and presentation of endogenous antigen (GO:0019883)2.66388765
101deoxyribonucleotide biosynthetic process (GO:0009263)2.66185349
102nucleotide-excision repair (GO:0006289)2.64939670
103establishment of mitotic spindle localization (GO:0040001)2.64768375
104microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.64297777
105blood vessel maturation (GO:0001955)2.63553629
106heterochromatin organization (GO:0070828)2.63213297
107mitotic cell cycle (GO:0000278)2.62093421
108COPII vesicle coating (GO:0048208)2.61851772
109aspartate family amino acid biosynthetic process (GO:0009067)2.61592245
110T cell apoptotic process (GO:0070231)2.60984524
111regulation of spindle checkpoint (GO:0090231)2.60917688
112metaphase plate congression (GO:0051310)2.59925161
113establishment of chromosome localization (GO:0051303)2.59594813
114tetrahydrofolate metabolic process (GO:0046653)2.58643396
115spindle assembly involved in mitosis (GO:0090307)2.58640843
116methionine biosynthetic process (GO:0009086)2.58511311
117Golgi transport vesicle coating (GO:0048200)2.57546842
118COPI coating of Golgi vesicle (GO:0048205)2.57546842
119mitotic spindle organization (GO:0007052)2.57498324
120pseudouridine synthesis (GO:0001522)2.56282956
121DNA-dependent DNA replication (GO:0006261)2.56005652
122peptidyl-lysine dimethylation (GO:0018027)2.55560567
123nucleobase biosynthetic process (GO:0046112)2.55505462
124folic acid metabolic process (GO:0046655)2.55103053
125mitotic G1 DNA damage checkpoint (GO:0031571)2.54788066
126tRNA aminoacylation (GO:0043039)2.53927765
127amino acid activation (GO:0043038)2.53927765
128snRNA metabolic process (GO:0016073)2.52605552
129spliceosomal tri-snRNP complex assembly (GO:0000244)2.51967578
130formation of translation preinitiation complex (GO:0001731)2.51327266
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.51306435
132telomere maintenance (GO:0000723)2.50307192
133histone mRNA catabolic process (GO:0071044)2.49979701
134non-recombinational repair (GO:0000726)2.49953037
135regulation of centrosome cycle (GO:0046605)2.49846256
136negative regulation of phagocytosis (GO:0050765)2.49687003
137ATP-dependent chromatin remodeling (GO:0043044)2.49572739
138regulation of nucleobase-containing compound transport (GO:0032239)2.48341596
139spindle checkpoint (GO:0031577)2.48201442
140telomere organization (GO:0032200)2.48084914
141negative regulation of RNA splicing (GO:0033119)2.47485636
142* postreplication repair (GO:0006301)2.47212902
143histone phosphorylation (GO:0016572)2.46885400
144histone exchange (GO:0043486)2.45274166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.69092576
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.57567870
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.99589789
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.89100831
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.28147083
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09021721
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02224518
8MYC_22102868_ChIP-Seq_BL_Human2.93782684
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82044373
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.64177883
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.56241303
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.45879398
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41557335
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.33229863
15AR_21909140_ChIP-Seq_LNCAP_Human2.31767144
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02705751
17VDR_21846776_ChIP-Seq_THP-1_Human1.95358130
18ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94573183
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91751882
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83843865
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81031950
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77348557
23* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76795701
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76562383
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75966693
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.75901808
27* SRF_21415370_ChIP-Seq_HL-1_Mouse1.71301591
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68644271
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63743935
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60024696
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58825622
32CIITA_25753668_ChIP-Seq_RAJI_Human1.58636814
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58571888
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58381344
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51730040
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51418498
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51218045
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49782826
39* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49637217
40MAF_26560356_Chip-Seq_TH1_Human1.45692437
41MYB_26560356_Chip-Seq_TH2_Human1.44740119
42* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44480763
43* XRN2_22483619_ChIP-Seq_HELA_Human1.43178884
44ZNF274_21170338_ChIP-Seq_K562_Hela1.42841526
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.42337586
46ELK1_19687146_ChIP-ChIP_HELA_Human1.42111002
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41640503
48VDR_23849224_ChIP-Seq_CD4+_Human1.41506534
49UTX_26944678_Chip-Seq_JUKART_Human1.41327757
50MYB_26560356_Chip-Seq_TH1_Human1.41085263
51* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38957638
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37237946
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.36802732
54TCF7_22412390_ChIP-Seq_EML_Mouse1.35792948
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35435582
56KDM5A_27292631_Chip-Seq_BREAST_Human1.35126566
57FOXP3_21729870_ChIP-Seq_TREG_Human1.32001987
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31066949
59TP53_22127205_ChIP-Seq_IMR90_Human1.30411942
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29985735
61* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29371553
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29112643
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28733664
64SCL_19346495_ChIP-Seq_HPC-7_Human1.24800398
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24142980
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21706424
67BRD4_25478319_ChIP-Seq_HGPS_Human1.20203762
68IRF1_19129219_ChIP-ChIP_H3396_Human1.18867235
69TFEB_21752829_ChIP-Seq_HELA_Human1.18314724
70ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17585999
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17343053
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16422743
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16248367
74SPI1_23547873_ChIP-Seq_NB4_Human1.16095732
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.16089476
76VDR_24763502_ChIP-Seq_THP-1_Human1.15933722
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13845262
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.13658190
79MYC_18940864_ChIP-ChIP_HL60_Human1.12713074
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12621051
81DCP1A_22483619_ChIP-Seq_HELA_Human1.11219456
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11080018
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.09709125
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09705108
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09162018
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09124584
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08744184
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08481805
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07408835
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06373985
91PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06267563
92GABP_19822575_ChIP-Seq_HepG2_Human1.05433163
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04663507
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03724057
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03266404
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03266404
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03131881
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02345949
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02139326
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02052292
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01433425
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.00585524
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00344879
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00182070
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99813550
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99601943
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98500023
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98453645
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.98242307
110GABP_17652178_ChIP-ChIP_JURKAT_Human0.98211437
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97881940
112KDM2B_26808549_Chip-Seq_DND41_Human0.97261781
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96665379
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96505143
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96503216
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96491030
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96326312
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96314496
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96133671
120TTF2_22483619_ChIP-Seq_HELA_Human0.94723400
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94701826
122MAF_26560356_Chip-Seq_TH2_Human0.94312593
123NCOR1_26117541_ChIP-Seq_K562_Human0.94162288
124* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94149679
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92942188
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91174722
127GATA1_22025678_ChIP-Seq_K562_Human0.91131212
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90827341
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89696898
130YY1_21170310_ChIP-Seq_MESCs_Mouse0.89426939
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88868095
132CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88194108
133MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83976632
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83682334
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81454640
136NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80150979
137ATF3_27146783_Chip-Seq_COLON_Human0.79957581
138GATA4_21415370_ChIP-Seq_HL-1_Mouse0.79873421
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.77350505
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75946196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane3.65350803
2MP0010094_abnormal_chromosome_stability3.48223804
3MP0003111_abnormal_nucleus_morphology3.20547919
4MP0010352_gastrointestinal_tract_polyps2.86533861
5MP0003705_abnormal_hypodermis_morpholog2.82744130
6MP0003693_abnormal_embryo_hatching2.82623754
7MP0003077_abnormal_cell_cycle2.79807485
8MP0008057_abnormal_DNA_replication2.58914306
9MP0010307_abnormal_tumor_latency2.56800724
10MP0006054_spinal_hemorrhage2.49822641
11MP0002396_abnormal_hematopoietic_system2.45217178
12MP0004808_abnormal_hematopoietic_stem2.40860954
13MP0004957_abnormal_blastocyst_morpholog2.32414540
14MP0002877_abnormal_melanocyte_morpholog2.21072290
15MP0008438_abnormal_cutaneous_collagen2.19927514
16MP0003300_gastrointestinal_ulcer2.18022623
17MP0005171_absent_coat_pigmentation2.07995778
18MP0003786_premature_aging2.00941464
19MP0005076_abnormal_cell_differentiation1.93207000
20MP0001730_embryonic_growth_arrest1.79818959
21MP0003656_abnormal_erythrocyte_physiolo1.79344679
22MP0002166_altered_tumor_susceptibility1.78737704
23MP0008007_abnormal_cellular_replicative1.75057255
24MP0002398_abnormal_bone_marrow1.74843552
25MP0000350_abnormal_cell_proliferation1.70552890
26MP0005397_hematopoietic_system_phenotyp1.69599355
27MP0001545_abnormal_hematopoietic_system1.69599355
28MP0004272_abnormal_basement_membrane1.67798574
29MP0000358_abnormal_cell_content/1.66284071
30MP0009697_abnormal_copulation1.65303317
31MP0001661_extended_life_span1.59079903
32MP0003566_abnormal_cell_adhesion1.57393199
33MP0003763_abnormal_thymus_physiology1.56944902
34MP0001800_abnormal_humoral_immune1.56876018
35MP0006035_abnormal_mitochondrial_morpho1.56249276
36MP0003303_peritoneal_inflammation1.55080569
37MP0000703_abnormal_thymus_morphology1.52846642
38MP0000685_abnormal_immune_system1.50700599
39MP0002722_abnormal_immune_system1.48800318
40MP0000689_abnormal_spleen_morphology1.48684432
41MP0003941_abnormal_skin_development1.48494602
42MP0000372_irregular_coat_pigmentation1.46986315
43MP0000490_abnormal_crypts_of1.46581219
44MP0005408_hypopigmentation1.45361890
45MP0009333_abnormal_splenocyte_physiolog1.42293096
46MP0005257_abnormal_intraocular_pressure1.41959841
47MP0001835_abnormal_antigen_presentation1.39624970
48MP0000569_abnormal_digit_pigmentation1.39408489
49* MP0002019_abnormal_tumor_incidence1.39280236
50MP0001958_emphysema1.37755546
51MP0002006_tumorigenesis1.35506667
52MP0009278_abnormal_bone_marrow1.34010169
53MP0002102_abnormal_ear_morphology1.33351432
54MP0008058_abnormal_DNA_repair1.32121798
55MP0000013_abnormal_adipose_tissue1.32003005
56MP0000733_abnormal_muscle_development1.29977189
57MP0004197_abnormal_fetal_growth/weight/1.29172036
58MP0005380_embryogenesis_phenotype1.28907840
59MP0001672_abnormal_embryogenesis/_devel1.28907840
60* MP0002452_abnormal_antigen_presenting1.28336291
61MP0003984_embryonic_growth_retardation1.27799643
62MP0000427_abnormal_hair_cycle1.26047903
63MP0002086_abnormal_extraembryonic_tissu1.25541515
64MP0002429_abnormal_blood_cell1.25412699
65MP0002088_abnormal_embryonic_growth/wei1.25164029
66MP0005023_abnormal_wound_healing1.24008319
67MP0002080_prenatal_lethality1.23874684
68MP0000716_abnormal_immune_system1.23455593
69MP0001697_abnormal_embryo_size1.22654989
70MP0008932_abnormal_embryonic_tissue1.21824214
71MP0005671_abnormal_response_to1.20908202
72MP0001915_intracranial_hemorrhage1.17890290
73* MP0002420_abnormal_adaptive_immunity1.17696521
74MP0004147_increased_porphyrin_level1.16792766
75* MP0001819_abnormal_immune_cell1.14988589
76MP0000313_abnormal_cell_death1.11756163
77MP0001986_abnormal_taste_sensitivity1.09412366
78MP0002723_abnormal_immune_serum1.08281474
79MP0004947_skin_inflammation1.06971732
80MP0003436_decreased_susceptibility_to1.05883676
81MP0005451_abnormal_body_composition1.05666506
82MP0002405_respiratory_system_inflammati1.05179870
83MP0003718_maternal_effect1.04577828
84MP0005464_abnormal_platelet_physiology1.04061597
85MP0005275_abnormal_skin_tensile1.03650504
86MP0001790_abnormal_immune_system1.02198026
87MP0005387_immune_system_phenotype1.02198026
88MP0002234_abnormal_pharynx_morphology1.01919292
89MP0003279_aneurysm1.01086861
90MP0003091_abnormal_cell_migration0.99623889
91MP0000003_abnormal_adipose_tissue0.99432239
92MP0002084_abnormal_developmental_patter0.98473833
93MP0003123_paternal_imprinting0.98193962
94MP0004134_abnormal_chest_morphology0.96684748
95MP0002085_abnormal_embryonic_tissue0.95392159
96MP0005000_abnormal_immune_tolerance0.95322307
97MP0005174_abnormal_tail_pigmentation0.93981938
98MP0003385_abnormal_body_wall0.91330130
99* MP0000015_abnormal_ear_pigmentation0.90614731
100MP0000465_gastrointestinal_hemorrhage0.88867620
101MP0002876_abnormal_thyroid_physiology0.88862692
102MP0001348_abnormal_lacrimal_gland0.88829588
103MP0001243_abnormal_dermal_layer0.86576760
104MP0010155_abnormal_intestine_physiology0.86566613
105MP0000858_altered_metastatic_potential0.86143112
106MP0002933_joint_inflammation0.85475689
107MP0005621_abnormal_cell_physiology0.85420914
108MP0003806_abnormal_nucleotide_metabolis0.80773213
109MP0001873_stomach_inflammation0.80383848
110MP0008877_abnormal_DNA_methylation0.79831131
111MP0003567_abnormal_fetal_cardiomyocyte0.78297562
112MP0004233_abnormal_muscle_weight0.77459556
113* MP0005501_abnormal_skin_physiology0.77013820
114MP0005503_abnormal_tendon_morphology0.76747296
115MP0005395_other_phenotype0.76662138
116* MP0002095_abnormal_skin_pigmentation0.76353155
117MP0003448_altered_tumor_morphology0.76069235
118MP0002009_preneoplasia0.76028252
119MP0005025_abnormal_response_to0.74659108
120MP0001849_ear_inflammation0.74636568
121MP0001853_heart_inflammation0.74395427
122MP0005623_abnormal_meninges_morphology0.72922139
123MP0000371_diluted_coat_color0.72394807
124MP0005384_cellular_phenotype0.72347909
125MP0002168_other_aberrant_phenotype0.71390122
126MP0001119_abnormal_female_reproductive0.71037229
127MP0000598_abnormal_liver_morphology0.70894547
128MP0001542_abnormal_bone_strength0.70413674
129MP0005266_abnormal_metabolism0.69719527
130MP0003959_abnormal_lean_body0.69233625
131MP0001270_distended_abdomen0.68993085
132MP0001881_abnormal_mammary_gland0.68526476
133MP0000647_abnormal_sebaceous_gland0.67955554
134MP0002060_abnormal_skin_morphology0.67793731
135MP0002970_abnormal_white_adipose0.67549177
136MP0004185_abnormal_adipocyte_glucose0.67128008
137MP0002925_abnormal_cardiovascular_devel0.67027576
138MP0009384_cardiac_valve_regurgitation0.66860953
139MP0003943_abnormal_hepatobiliary_system0.66816746
140MP0002419_abnormal_innate_immunity0.66519828
141MP0001216_abnormal_epidermal_layer0.66464750
142MP0009672_abnormal_birth_weight0.66318529
143* MP0001191_abnormal_skin_condition0.66266261
144MP0008770_decreased_survivor_rate0.66091753
145MP0009780_abnormal_chondrocyte_physiolo0.66063024
146MP0002938_white_spotting0.64913502

Predicted human phenotypes

RankGene SetZ-score
1* Poikiloderma (HP:0001029)3.45295854
2* Squamous cell carcinoma (HP:0002860)3.35026253
3Abnormality of the ileum (HP:0001549)3.06674887
4* Entropion (HP:0000621)3.01940778
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.00345979
6Short 4th metacarpal (HP:0010044)3.00345979
7Aplasia/Hypoplasia of the uvula (HP:0010293)2.95243086
8Abnormality of DNA repair (HP:0003254)2.85735100
9Abnormality of the preputium (HP:0100587)2.83717134
10Meckel diverticulum (HP:0002245)2.82117487
11Cellulitis (HP:0100658)2.81310307
12Abnormality of the carotid arteries (HP:0005344)2.79509992
13Increased density of long bones (HP:0006392)2.78306417
14Duodenal stenosis (HP:0100867)2.72343438
15Small intestinal stenosis (HP:0012848)2.72343438
16Recurrent viral infections (HP:0004429)2.58477113
17Microvesicular hepatic steatosis (HP:0001414)2.58419628
18High pitched voice (HP:0001620)2.55745940
19Flat cornea (HP:0007720)2.55655998
20Abnormal platelet volume (HP:0011876)2.54438339
21Abnormality of the fingertips (HP:0001211)2.53907618
22Recurrent bronchitis (HP:0002837)2.49066926
23Follicular hyperkeratosis (HP:0007502)2.48959889
24Protrusio acetabuli (HP:0003179)2.48141496
25Selective tooth agenesis (HP:0001592)2.48086460
26Aortic dissection (HP:0002647)2.45894351
27Increased mean platelet volume (HP:0011877)2.43658786
28Cerebellar dysplasia (HP:0007033)2.41972771
29Ankle contracture (HP:0006466)2.41741785
30T lymphocytopenia (HP:0005403)2.38250797
31Increased nuchal translucency (HP:0010880)2.37347329
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.35814664
33Osteolytic defects of the hand bones (HP:0009699)2.35814664
34Abnormality of the calcaneus (HP:0008364)2.34268772
35Sloping forehead (HP:0000340)2.29975182
36Hyperacusis (HP:0010780)2.29645425
37Deviation of the thumb (HP:0009603)2.28426552
38Premature rupture of membranes (HP:0001788)2.27754600
39Volvulus (HP:0002580)2.27485053
40Abnormality of T cell number (HP:0011839)2.22210243
41Cerebral aneurysm (HP:0004944)2.21910312
42Ulnar bowing (HP:0003031)2.21195710
43Thrombocytosis (HP:0001894)2.19817762
44* Papilloma (HP:0012740)2.17584828
45* Verrucae (HP:0200043)2.17584828
46Decreased subcutaneous fat (HP:0001002)2.16666623
47Short chin (HP:0000331)2.15625982
48Proximal placement of thumb (HP:0009623)2.14622286
49Abnormality of the 4th metacarpal (HP:0010012)2.14239661
50Hypoplasia of the pons (HP:0012110)2.13358010
51IgM deficiency (HP:0002850)2.10503834
52Soft skin (HP:0000977)2.08965307
53Long eyelashes (HP:0000527)2.08729276
54Abnormality of the duodenum (HP:0002246)2.08019610
55Atrophic scars (HP:0001075)2.07983561
56Abnormality of chromosome stability (HP:0003220)2.07796176
57Abnormality of the peritoneum (HP:0002585)2.07629074
58Chromsome breakage (HP:0040012)2.07176811
59Cervical subluxation (HP:0003308)2.06482923
60Abnormal foot bone ossification (HP:0010675)2.06212180
61Agammaglobulinemia (HP:0004432)2.05035127
62Chronic hepatic failure (HP:0100626)2.03507699
63Deep philtrum (HP:0002002)2.01794179
64Prominent nose (HP:0000448)2.00517854
65Abnormality of T cells (HP:0002843)1.99457109
66Syringomyelia (HP:0003396)1.98533501
67Spinal cord lesions (HP:0100561)1.98533501
68Abnormality of B cell number (HP:0010975)1.98324554
69B lymphocytopenia (HP:0010976)1.98324554
70Abnormality of the pons (HP:0007361)1.97102024
71Bowel diverticulosis (HP:0005222)1.96213508
72Reticulocytopenia (HP:0001896)1.96192943
73Poikilocytosis (HP:0004447)1.95697879
74Acute myeloid leukemia (HP:0004808)1.94101156
75Absent frontal sinuses (HP:0002688)1.93639972
76Abnormality of subcutaneous fat tissue (HP:0001001)1.91301144
77Spondylolisthesis (HP:0003302)1.88053343
78Persistence of primary teeth (HP:0006335)1.87674076
79Small hand (HP:0200055)1.87399027
80Clubbing of toes (HP:0100760)1.87169134
81IgA deficiency (HP:0002720)1.86089246
82Aortic aneurysm (HP:0004942)1.85924575
83Peritonitis (HP:0002586)1.85764854
84Subacute progressive viral hepatitis (HP:0006572)1.85391229
85Thyroid-stimulating hormone excess (HP:0002925)1.83557816
86Ependymoma (HP:0002888)1.82988563
87Bicuspid aortic valve (HP:0001647)1.82605329
88Colon cancer (HP:0003003)1.82536682
89Distal lower limb amyotrophy (HP:0008944)1.81484884
90Abnormal glycosylation (HP:0012345)1.81085895
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81085895
92Abnormal protein N-linked glycosylation (HP:0012347)1.81085895
93Abnormal protein glycosylation (HP:0012346)1.81085895
94Shallow orbits (HP:0000586)1.80814536
95Osteomyelitis (HP:0002754)1.80579556
96Myelodysplasia (HP:0002863)1.80268268
97Dilatation of the ascending aorta (HP:0005111)1.80120958
98Lymphoma (HP:0002665)1.79018496
99* Cutaneous melanoma (HP:0012056)1.78723945
100Upper limb muscle weakness (HP:0003484)1.78208529
101Panhypogammaglobulinemia (HP:0003139)1.77846256
102Abnormality of oral frenula (HP:0000190)1.77725673
103Recurrent fungal infections (HP:0002841)1.77226509
104Cafe-au-lait spot (HP:0000957)1.76118186
105Abnormal delayed hypersensitivity skin test (HP:0002963)1.74912515
106Vascular tortuosity (HP:0004948)1.73807042
107Renovascular hypertension (HP:0100817)1.73054444
108Albinism (HP:0001022)1.72918842
109Nonimmune hydrops fetalis (HP:0001790)1.72652550
110Birth length less than 3rd percentile (HP:0003561)1.72639290
111Abnormality of reticulocytes (HP:0004312)1.72429680
112Arteriovenous malformation (HP:0100026)1.72259597
113Increased corneal curvature (HP:0100692)1.72251914
114Keratoconus (HP:0000563)1.72251914
115Abnormality of the heme biosynthetic pathway (HP:0010472)1.72240863
116Type II lissencephaly (HP:0007260)1.71732175
117Stillbirth (HP:0003826)1.71002875
118Cutis marmorata (HP:0000965)1.70896813
119Spontaneous hematomas (HP:0007420)1.70836383
120Abnormality of T cell physiology (HP:0011840)1.70688156
121Delayed closure of the anterior fontanelle (HP:0001476)1.70348665
122Abnormality of the acetabulum (HP:0003170)1.70211531
123Elbow flexion contracture (HP:0002987)1.70002128
124Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69931566
125Papilledema (HP:0001085)1.69893295
126Nasal polyposis (HP:0100582)1.69664508
127Elfin facies (HP:0004428)1.69340417
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.69047049
129Poor head control (HP:0002421)1.69000818
130Patellar aplasia (HP:0006443)1.68302232
131Heterotopia (HP:0002282)1.68249333
132* Basal cell carcinoma (HP:0002671)1.68085036
133Natal tooth (HP:0000695)1.68001429
134Small epiphyses (HP:0010585)1.67901088
135Asymmetry of the thorax (HP:0001555)1.67720258
136Aplasia/Hypoplasia of the patella (HP:0006498)1.67670908
13711 pairs of ribs (HP:0000878)1.67588225
138Hypoplastic iliac wings (HP:0002866)1.67539647
139Bladder diverticulum (HP:0000015)1.67473968
140Mitral valve prolapse (HP:0001634)1.67372257
141Ulnar deviation of the wrist (HP:0003049)1.67102779
142Coxa valga (HP:0002673)1.66210040
143Lymphopenia (HP:0001888)1.66179146
144Tubular atrophy (HP:0000092)1.65984578
145Pelvic girdle muscle weakness (HP:0003749)1.65974876
146Arterial tortuosity (HP:0005116)1.65723944
147Genu recurvatum (HP:0002816)1.65445693
148Duplicated collecting system (HP:0000081)1.65242185
149Slender long bone (HP:0003100)1.63476531
150Overlapping toe (HP:0001845)1.63309156
151Wrist flexion contracture (HP:0001239)1.62729995
152Abnormality of alanine metabolism (HP:0010916)1.62426538
153Hyperalaninemia (HP:0003348)1.62426538
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62426538
155Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62295855
156Abnormality of the renal cortex (HP:0011035)1.62022573
157Aortic valve stenosis (HP:0001650)1.61784144
158Spastic diplegia (HP:0001264)1.61360824
159Abnormality of nail color (HP:0100643)1.61168475
160Progressive inability to walk (HP:0002505)1.60311894
161Hematochezia (HP:0002573)1.60208155
162Mesomelia (HP:0003027)1.60201464
163Gastrointestinal inflammation (HP:0004386)1.60017916
164Microglossia (HP:0000171)1.59576394
165Pancreatic cysts (HP:0001737)1.59515664
166Abnormality of the wing of the ilium (HP:0011867)1.59151009
167Reticulocytosis (HP:0001923)1.59062845
168Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58728391
169Overriding aorta (HP:0002623)1.58163372
170Sandal gap (HP:0001852)1.57097803
171Ectopic kidney (HP:0000086)1.54405517
172Redundant skin (HP:0001582)1.54099494
173Ureteral duplication (HP:0000073)1.52177530
174Horseshoe kidney (HP:0000085)1.51812344
175Absent thumb (HP:0009777)1.51566487
176Renal duplication (HP:0000075)1.50415766
177Blepharitis (HP:0000498)1.50105928
178Carpal bone hypoplasia (HP:0001498)1.48869359
179Progressive muscle weakness (HP:0003323)1.48555866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.75132122
2EEF2K3.67746082
3TRIB33.12460424
4PKN22.93407922
5NEK22.86216347
6PBK2.68041280
7MAP3K102.58253978
8PIM22.47677237
9MAP4K12.36922620
10CDK122.28409270
11TTN2.26283817
12PLK42.13707929
13STK102.03970760
14NUAK11.98125648
15CDK81.94928773
16SCYL21.82740495
17STK41.67447558
18LRRK21.66575808
19WEE11.64331558
20NEK11.64112895
21CDK41.62325425
22MST41.52794641
23RPS6KB21.48627151
24TLK11.47401957
25RPS6KA41.44907457
26MET1.44251225
27MAP3K81.41251121
28BUB11.41185133
29CDK61.36521818
30JAK31.35147709
31EIF2AK11.30760983
32AURKB1.30312998
33GRK61.28007844
34WNK41.26509301
35PASK1.25971438
36KIT1.25567920
37* ATR1.25337679
38STK31.23590674
39ADRBK21.23511174
40BRSK21.20725056
41CCNB11.20167825
42TTK1.17649828
43PIM11.17129572
44MST1R1.15830650
45ACVR1B1.13254617
46ERBB41.10766302
47BCR1.10190829
48TYK21.09499577
49PTK61.06232815
50FLT31.05016765
51CHEK11.03131712
52ZAK1.02175549
53CSF1R1.01652207
54ALK0.98895591
55PLK10.98115792
56MELK0.96541939
57EPHA20.96000460
58PIK3CG0.95512460
59SRPK10.94744420
60TGFBR10.94695773
61BTK0.92953220
62SIK10.92545098
63TESK20.91140866
64MTOR0.91078842
65PINK10.90941439
66LATS10.90908427
67NME20.88503373
68ERN10.86250693
69AURKA0.85607110
70MAP2K30.84077671
71CHEK20.83980342
72CDK90.83257257
73PAK40.81347068
74EIF2AK20.80201878
75BRSK10.80060841
76PLK30.79962652
77MKNK10.79174721
78ATM0.78089675
79NEK90.76209536
80CLK10.76079611
81CAMK1D0.75443249
82BMX0.74830047
83ICK0.74640383
84ITK0.72849973
85CDK70.72594260
86VRK10.72473833
87ZAP700.72437647
88LIMK10.71618935
89MAP3K140.71370532
90PDGFRA0.71292438
91FGFR30.70380249
92PAK20.69150324
93SIK30.65701610
94TSSK60.64867617
95TESK10.64280516
96CDK20.63934574
97SYK0.63742946
98WNK10.62912107
99TRPM70.62548487
100JAK10.61943329
101FGFR40.59567240
102DYRK30.59423796
103MAPK110.59225516
104PDGFRB0.58828187
105EIF2AK30.58423340
106SIK20.58093331
107PRKCI0.56556326
108HCK0.54966205
109EPHA30.54897071
110BMPR1B0.53646051
111CSNK1A1L0.53512656
112RPS6KA50.53382916
113MARK30.52479069
114LCK0.49949593
115CSK0.49900193
116MAP3K120.49877343
117RIPK10.49169293
118MYLK0.48566024
119TEC0.47848967
120PRKD20.47806254
121CDK10.45633151
122IKBKB0.45595090
123CHUK0.45439381
124PLK20.45242094
125LYN0.44749864
126BRD40.44471560
127PRKCH0.41943304
128FRK0.41795003
129ADRBK10.41179116
130ILK0.39890526
131MATK0.38796285
132BLK0.38415379
133DYRK1B0.38199818
134AKT30.37549701
135RAF10.37255328
136PTK2B0.36738379
137VRK20.36053007
138CAMK1G0.35208251
139TAOK30.34617033
140TGFBR20.33831883
141MAPKAPK20.31376711
142MAPKAPK30.31170659
143MUSK0.30708990
144CAMKK20.29738204
145PTK20.29103037
146ABL10.27706097
147KSR10.26969593

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.02912952
2Mismatch repair_Homo sapiens_hsa034303.06086872
3Systemic lupus erythematosus_Homo sapiens_hsa053222.93970915
4One carbon pool by folate_Homo sapiens_hsa006702.79911451
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.68540946
6Cell cycle_Homo sapiens_hsa041102.61945432
7Base excision repair_Homo sapiens_hsa034102.44071718
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23724295
9RNA transport_Homo sapiens_hsa030132.23695151
10Viral carcinogenesis_Homo sapiens_hsa052031.99536780
11Primary immunodeficiency_Homo sapiens_hsa053401.97754621
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94363735
13Spliceosome_Homo sapiens_hsa030401.92681913
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90982401
15Proteasome_Homo sapiens_hsa030501.89500122
16Non-homologous end-joining_Homo sapiens_hsa034501.78724706
17Nucleotide excision repair_Homo sapiens_hsa034201.74782204
18p53 signaling pathway_Homo sapiens_hsa041151.74148000
19Homologous recombination_Homo sapiens_hsa034401.67521047
20Small cell lung cancer_Homo sapiens_hsa052221.58263365
21Antigen processing and presentation_Homo sapiens_hsa046121.53201239
22B cell receptor signaling pathway_Homo sapiens_hsa046621.51973603
23Chronic myeloid leukemia_Homo sapiens_hsa052201.51082811
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42440523
25Protein export_Homo sapiens_hsa030601.30973579
26Measles_Homo sapiens_hsa051621.28964502
27MicroRNAs in cancer_Homo sapiens_hsa052061.28771576
28mRNA surveillance pathway_Homo sapiens_hsa030151.24619177
29HTLV-I infection_Homo sapiens_hsa051661.24069345
30* Fanconi anemia pathway_Homo sapiens_hsa034601.23669043
31Herpes simplex infection_Homo sapiens_hsa051681.20962771
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.19345595
33Selenocompound metabolism_Homo sapiens_hsa004501.18596625
34Alcoholism_Homo sapiens_hsa050341.17584332
35Viral myocarditis_Homo sapiens_hsa054161.17038378
36Epstein-Barr virus infection_Homo sapiens_hsa051691.13273203
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12346918
38Apoptosis_Homo sapiens_hsa042101.11992395
39Sulfur relay system_Homo sapiens_hsa041221.11325543
40Hepatitis B_Homo sapiens_hsa051611.11047332
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10248093
42Non-small cell lung cancer_Homo sapiens_hsa052231.09412092
43Pancreatic cancer_Homo sapiens_hsa052121.08588151
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06931336
45Hematopoietic cell lineage_Homo sapiens_hsa046401.01037285
46RNA degradation_Homo sapiens_hsa030181.00194286
47Lysine degradation_Homo sapiens_hsa003100.98427165
48Pyrimidine metabolism_Homo sapiens_hsa002400.98226733
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96237402
50Toxoplasmosis_Homo sapiens_hsa051450.95720373
51Ribosome_Homo sapiens_hsa030100.95624208
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95429597
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95010276
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.94793380
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93084284
56Acute myeloid leukemia_Homo sapiens_hsa052210.91731437
57Purine metabolism_Homo sapiens_hsa002300.91150524
58Leishmaniasis_Homo sapiens_hsa051400.90973021
59T cell receptor signaling pathway_Homo sapiens_hsa046600.89695946
60Pentose phosphate pathway_Homo sapiens_hsa000300.89545802
61Legionellosis_Homo sapiens_hsa051340.88296353
62mTOR signaling pathway_Homo sapiens_hsa041500.87006355
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86804069
64Colorectal cancer_Homo sapiens_hsa052100.86078404
65Osteoclast differentiation_Homo sapiens_hsa043800.85172512
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84094612
67Shigellosis_Homo sapiens_hsa051310.83966209
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.83508627
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81022229
70Thyroid cancer_Homo sapiens_hsa052160.80961537
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80363728
72Biosynthesis of amino acids_Homo sapiens_hsa012300.76121245
73Platelet activation_Homo sapiens_hsa046110.75908482
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.74359385
75Proteoglycans in cancer_Homo sapiens_hsa052050.74308290
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.73591998
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72500853
78Influenza A_Homo sapiens_hsa051640.72039124
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71870829
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70797787
81Focal adhesion_Homo sapiens_hsa045100.70786705
82Sphingolipid metabolism_Homo sapiens_hsa006000.70317057
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.70269132
84Prostate cancer_Homo sapiens_hsa052150.69372361
85RNA polymerase_Homo sapiens_hsa030200.69088706
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69023938
87Melanoma_Homo sapiens_hsa052180.67675181
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67144336
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66405987
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.64569903
91FoxO signaling pathway_Homo sapiens_hsa040680.62997682
92HIF-1 signaling pathway_Homo sapiens_hsa040660.62512346
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61893991
94Adherens junction_Homo sapiens_hsa045200.61762165
95TGF-beta signaling pathway_Homo sapiens_hsa043500.58160054
96Bladder cancer_Homo sapiens_hsa052190.58024706
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.56034719
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55004456
99Inositol phosphate metabolism_Homo sapiens_hsa005620.54555797
100Folate biosynthesis_Homo sapiens_hsa007900.54427430
101Insulin resistance_Homo sapiens_hsa049310.53012243
102ECM-receptor interaction_Homo sapiens_hsa045120.52792550
103Endometrial cancer_Homo sapiens_hsa052130.52443196
104N-Glycan biosynthesis_Homo sapiens_hsa005100.52161491
105Vitamin B6 metabolism_Homo sapiens_hsa007500.50754277
106Malaria_Homo sapiens_hsa051440.49364678
107Oocyte meiosis_Homo sapiens_hsa041140.49357607
108Hippo signaling pathway_Homo sapiens_hsa043900.47759005
109VEGF signaling pathway_Homo sapiens_hsa043700.47330407
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47183852
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46139010
112TNF signaling pathway_Homo sapiens_hsa046680.45640880
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44969992
114Basal transcription factors_Homo sapiens_hsa030220.43591218
115Tuberculosis_Homo sapiens_hsa051520.43447369
116Pathways in cancer_Homo sapiens_hsa052000.42632039
117Sulfur metabolism_Homo sapiens_hsa009200.42559180
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42433582
119AMPK signaling pathway_Homo sapiens_hsa041520.42072207
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41474661
121Glioma_Homo sapiens_hsa052140.39545751
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39186999
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.38820543
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.38201405
125Glutathione metabolism_Homo sapiens_hsa004800.37542465
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37386438
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37343223
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35311761
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33049444
130Propanoate metabolism_Homo sapiens_hsa006400.32558404
131Metabolic pathways_Homo sapiens_hsa011000.30546785
132Nitrogen metabolism_Homo sapiens_hsa009100.29959176
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28123699
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25765832
135ABC transporters_Homo sapiens_hsa020100.24884673
136Steroid biosynthesis_Homo sapiens_hsa001000.22565337
137Fatty acid elongation_Homo sapiens_hsa000620.21384830

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