POLK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.75569866
2protein prenylation (GO:0018342)4.16700374
3prenylation (GO:0097354)4.16700374
4cilium or flagellum-dependent cell motility (GO:0001539)4.16581956
5neural tube formation (GO:0001841)3.91826206
6nuclear pore complex assembly (GO:0051292)3.82783148
7positive regulation of macrophage differentiation (GO:0045651)3.74033775
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69890835
9regulation of hexokinase activity (GO:1903299)3.69716671
10regulation of glucokinase activity (GO:0033131)3.69716671
11axonemal dynein complex assembly (GO:0070286)3.68781023
12fusion of sperm to egg plasma membrane (GO:0007342)3.66401379
13protein localization to cilium (GO:0061512)3.63641181
14centriole replication (GO:0007099)3.57317768
15DNA double-strand break processing (GO:0000729)3.55791978
16establishment of protein localization to Golgi (GO:0072600)3.49938029
17platelet dense granule organization (GO:0060155)3.41482460
18pore complex assembly (GO:0046931)3.41473876
19cilium morphogenesis (GO:0060271)3.38262648
20cell wall macromolecule metabolic process (GO:0044036)3.28632044
21cell wall macromolecule catabolic process (GO:0016998)3.28632044
22intraciliary transport (GO:0042073)3.27136555
23hepatocyte apoptotic process (GO:0097284)3.23232137
24neutrophil activation involved in immune response (GO:0002283)3.22687245
25L-fucose catabolic process (GO:0042355)3.22491603
26fucose catabolic process (GO:0019317)3.22491603
27L-fucose metabolic process (GO:0042354)3.22491603
28replication fork processing (GO:0031297)3.22380224
29monoubiquitinated protein deubiquitination (GO:0035520)3.20894827
30protein targeting to Golgi (GO:0000042)3.16793025
31polyol catabolic process (GO:0046174)3.15100152
32nuclear pore organization (GO:0006999)3.14937117
33ribosomal small subunit assembly (GO:0000028)3.10674320
34inositol phosphate catabolic process (GO:0071545)3.10429193
35cellular ketone body metabolic process (GO:0046950)3.08318832
36cilium organization (GO:0044782)3.07867672
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06753518
38signal peptide processing (GO:0006465)3.04556746
39cilium assembly (GO:0042384)3.02832796
40positive regulation of astrocyte differentiation (GO:0048711)3.01744882
41motile cilium assembly (GO:0044458)3.01577723
42DNA deamination (GO:0045006)2.99962662
43interkinetic nuclear migration (GO:0022027)2.94622803
44indole-containing compound catabolic process (GO:0042436)2.91876519
45indolalkylamine catabolic process (GO:0046218)2.91876519
46tryptophan catabolic process (GO:0006569)2.91876519
47morphogenesis of an endothelium (GO:0003159)2.91838758
48endothelial tube morphogenesis (GO:0061154)2.91838758
49seminiferous tubule development (GO:0072520)2.89717117
50axoneme assembly (GO:0035082)2.89600775
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89120795
52indolalkylamine metabolic process (GO:0006586)2.88569514
53retrograde transport, vesicle recycling within Golgi (GO:0000301)2.87209534
54vascular endothelial growth factor signaling pathway (GO:0038084)2.86730053
55anterograde synaptic vesicle transport (GO:0048490)2.85718569
56double-strand break repair via homologous recombination (GO:0000724)2.81745840
57recombinational repair (GO:0000725)2.80709443
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79303441
59behavioral response to nicotine (GO:0035095)2.78924563
60magnesium ion transport (GO:0015693)2.78426689
61cell adhesion mediated by integrin (GO:0033627)2.78301022
62definitive hemopoiesis (GO:0060216)2.77536436
63protein localization to Golgi apparatus (GO:0034067)2.77401111
64adenosine metabolic process (GO:0046085)2.76783714
65ketone body metabolic process (GO:1902224)2.76747305
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75487284
67regulation of cilium movement (GO:0003352)2.74063688
68inositol phosphate dephosphorylation (GO:0046855)2.71584105
69phosphorylated carbohydrate dephosphorylation (GO:0046838)2.71584105
70positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.71569905
71granulocyte activation (GO:0036230)2.70830207
72microtubule anchoring (GO:0034453)2.70761927
73monocyte chemotaxis (GO:0002548)2.70365088
74embryonic process involved in female pregnancy (GO:0060136)2.69450505
75sequestering of actin monomers (GO:0042989)2.69130727
76cilium movement (GO:0003341)2.67105713
77cellular response to ethanol (GO:0071361)2.66371411
78negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66213130
79preassembly of GPI anchor in ER membrane (GO:0016254)2.65316845
80tryptophan metabolic process (GO:0006568)2.64044138
81neutrophil activation (GO:0042119)2.63409136
82chondrocyte proliferation (GO:0035988)2.62329696
83nonmotile primary cilium assembly (GO:0035058)2.61446550
84histone H2A monoubiquitination (GO:0035518)2.58743575
85positive regulation of glycolytic process (GO:0045821)2.57651374
86protein targeting to vacuole (GO:0006623)2.57630841
87protein targeting to lysosome (GO:0006622)2.57630841
88establishment of protein localization to vacuole (GO:0072666)2.57630841
89interferon-gamma production (GO:0032609)2.55736430
90photoreceptor cell maintenance (GO:0045494)2.55712740
91regulation of necroptotic process (GO:0060544)2.54134009
92reciprocal meiotic recombination (GO:0007131)2.53788757
93reciprocal DNA recombination (GO:0035825)2.53788757
94rRNA catabolic process (GO:0016075)2.52730801
95mesodermal cell differentiation (GO:0048333)2.52216558
96wound healing, spreading of epidermal cells (GO:0035313)2.51701411
97positive regulation of gamma-delta T cell activation (GO:0046645)2.51025026
98kynurenine metabolic process (GO:0070189)2.50954338
99regulation of meiosis I (GO:0060631)2.50746788
100cellular component assembly involved in morphogenesis (GO:0010927)2.49502427
101pyrimidine nucleobase catabolic process (GO:0006208)2.48705403
102protein polyglutamylation (GO:0018095)2.48102222
103pericardium development (GO:0060039)2.47897113
104regulation of telomere maintenance (GO:0032204)2.47794550
105hippo signaling (GO:0035329)2.47582960
106positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.47289342
107positive regulation of developmental pigmentation (GO:0048087)2.47235283
108multicellular organism reproduction (GO:0032504)2.45661305
109regulation of dendritic cell antigen processing and presentation (GO:0002604)2.44626083
110positive regulation of mitotic sister chromatid separation (GO:1901970)2.44472471
111positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.44472471
112positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.44472471
113detection of light stimulus involved in sensory perception (GO:0050962)2.44165042
114detection of light stimulus involved in visual perception (GO:0050908)2.44165042
115plasma membrane fusion (GO:0045026)2.44043597
116regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.43094417
117Golgi to endosome transport (GO:0006895)2.40461661
118lymph vessel development (GO:0001945)2.39405167
119prostate gland growth (GO:0060736)2.39310048
120protein K63-linked deubiquitination (GO:0070536)2.39053820
121S-adenosylmethionine metabolic process (GO:0046500)2.38898562
122water-soluble vitamin biosynthetic process (GO:0042364)2.38470982
123cAMP catabolic process (GO:0006198)2.38411805
124histone mRNA catabolic process (GO:0071044)2.38351032
125DNA integration (GO:0015074)2.38306019
126cyclic nucleotide catabolic process (GO:0009214)2.37044391
127intra-Golgi vesicle-mediated transport (GO:0006891)2.35865142
128myeloid dendritic cell differentiation (GO:0043011)2.34937042
129negative regulation of neurological system process (GO:0031645)2.34930677
130positive regulation of epithelial to mesenchymal transition (GO:0010718)2.34704341
131C-terminal protein lipidation (GO:0006501)2.34551934
132positive regulation of lymphocyte apoptotic process (GO:0070230)2.33552890
133regulation of pigment cell differentiation (GO:0050932)2.33547706
134dopamine transport (GO:0015872)2.33382351
135myeloid leukocyte mediated immunity (GO:0002444)2.33285408
136negative regulation by host of viral transcription (GO:0043922)2.33244574
137protein-cofactor linkage (GO:0018065)2.32861476
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.32341501
139mitochondrial respiratory chain complex I assembly (GO:0032981)2.32341501
140NADH dehydrogenase complex assembly (GO:0010257)2.32341501
141myeloid dendritic cell activation (GO:0001773)2.32131151
142hindbrain development (GO:0030902)2.31840413
143regulation of sarcomere organization (GO:0060297)2.31396085
144DNA demethylation (GO:0080111)2.31187131
145regulation of macrophage differentiation (GO:0045649)2.28583623
146regulation of chemokine-mediated signaling pathway (GO:0070099)2.28525438
147positive regulation of T cell apoptotic process (GO:0070234)2.28457684
148positive regulation of endothelial cell apoptotic process (GO:2000353)2.27970117
149natural killer cell differentiation (GO:0001779)2.27560705
150sperm-egg recognition (GO:0035036)2.26148015
151regulation of centriole replication (GO:0046599)2.25339376
152regulation of interferon-beta biosynthetic process (GO:0045357)2.24628577
153establishment of endothelial barrier (GO:0061028)2.23969283
154maturation of SSU-rRNA (GO:0030490)2.23880889
155regulation of RNA export from nucleus (GO:0046831)2.23001673
156negative regulation of DNA repair (GO:0045738)2.21688912
157substrate adhesion-dependent cell spreading (GO:0034446)2.21534298
158epithelial cilium movement (GO:0003351)2.19224769
159mitotic G2 DNA damage checkpoint (GO:0007095)2.18260790
160regulation of T cell chemotaxis (GO:0010819)2.18069800
161positive regulation of T cell chemotaxis (GO:0010820)2.18069800
162ventricular system development (GO:0021591)2.17461942
163positive regulation of monocyte chemotaxis (GO:0090026)2.15858969
164endodermal cell differentiation (GO:0035987)2.14642073
165tyrosine phosphorylation of STAT protein (GO:0007260)2.14009382
166regulation of fibroblast apoptotic process (GO:2000269)2.13387556
167regulation of T cell tolerance induction (GO:0002664)2.11917256
168natural killer cell activation (GO:0030101)2.11854478
169cell-cell recognition (GO:0009988)2.10255011
170regulation of interleukin-12 biosynthetic process (GO:0045075)2.09285573
171positive regulation of T cell mediated cytotoxicity (GO:0001916)2.07753329
172regulation of protein polyubiquitination (GO:1902914)2.06544587
173wound healing, spreading of cells (GO:0044319)2.06398708
174positive regulation of actin filament depolymerization (GO:0030836)2.06197611
175substrate-dependent cell migration (GO:0006929)2.06052900
176binding of sperm to zona pellucida (GO:0007339)2.04752458
177protein K11-linked deubiquitination (GO:0035871)2.04560779
178positive regulation of leukocyte apoptotic process (GO:2000108)2.04294357
179regulation of B cell differentiation (GO:0045577)2.03877120
180histone H2A ubiquitination (GO:0033522)2.03831895
181mitotic sister chromatid cohesion (GO:0007064)2.03144087
182regulation of tolerance induction (GO:0002643)2.03119225
183regulation of centrosome duplication (GO:0010824)2.03100959
184antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.02831053
185antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.02831053
186positive regulation of smooth muscle cell migration (GO:0014911)2.02583837
187DNA replication initiation (GO:0006270)2.02528173
188sprouting angiogenesis (GO:0002040)2.02486379
189negative regulation of B cell activation (GO:0050869)2.02348696
190collagen fibril organization (GO:0030199)2.02239372
191negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.02181259
192lymphangiogenesis (GO:0001946)2.02101229
193regulation of cellular extravasation (GO:0002691)2.01797808
194negative regulation of necroptotic process (GO:0060546)2.01358866
195mitotic G2/M transition checkpoint (GO:0044818)2.01052699
196intra-S DNA damage checkpoint (GO:0031573)2.00051244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.31592430
2E2F7_22180533_ChIP-Seq_HELA_Human4.91149787
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.24051150
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.11540186
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.03870484
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.02274388
7GBX2_23144817_ChIP-Seq_PC3_Human2.99599436
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.78048135
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75083304
10ZNF274_21170338_ChIP-Seq_K562_Hela2.71680863
11TAF15_26573619_Chip-Seq_HEK293_Human2.59600896
12VDR_22108803_ChIP-Seq_LS180_Human2.54301187
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52539924
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38722897
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.36887974
16FUS_26573619_Chip-Seq_HEK293_Human2.33001171
17EWS_26573619_Chip-Seq_HEK293_Human2.29673108
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25614688
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24968192
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23507309
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.21381332
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.18461198
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17958283
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.15913910
25P300_19829295_ChIP-Seq_ESCs_Human2.14806310
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00991269
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00347779
28ELK1_19687146_ChIP-ChIP_HELA_Human1.99599499
29SCL_19346495_ChIP-Seq_HPC-7_Human1.96926223
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.95057942
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93493340
32ER_23166858_ChIP-Seq_MCF-7_Human1.92147875
33* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92134720
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89058182
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.86521160
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84836779
37SMAD4_21799915_ChIP-Seq_A2780_Human1.84043142
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83900476
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.82846242
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81513839
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.80865818
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80377966
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79339792
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77898551
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76481458
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.75021294
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73338141
48* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72502959
49* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72428087
50RUNX_20019798_ChIP-Seq_JUKART_Human1.71559699
51IGF1R_20145208_ChIP-Seq_DFB_Human1.70885615
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70072751
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70072751
54BRD4_25478319_ChIP-Seq_HGPS_Human1.69970084
55STAT3_23295773_ChIP-Seq_U87_Human1.68886834
56* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68661789
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66601137
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65861422
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63942533
60CBP_20019798_ChIP-Seq_JUKART_Human1.63942533
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.62952802
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.62064203
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61514770
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61473574
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60694244
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58677528
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58001467
68MYB_26560356_Chip-Seq_TH2_Human1.57005416
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54816702
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54282044
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52801259
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51581448
73AR_25329375_ChIP-Seq_VCAP_Human1.51216719
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.51184427
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50951605
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.50595448
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49658794
78TCF4_23295773_ChIP-Seq_U87_Human1.48807689
79CJUN_26792858_Chip-Seq_BT549_Human1.48705017
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47584998
81AR_21909140_ChIP-Seq_LNCAP_Human1.47141780
82BCAT_22108803_ChIP-Seq_LS180_Human1.45902352
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.45298060
84MYB_26560356_Chip-Seq_TH1_Human1.45276068
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.42849978
86* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42171814
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41615896
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41357929
89EZH2_22144423_ChIP-Seq_EOC_Human1.40411342
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.40327896
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40154368
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39648593
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38829565
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38552145
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37923016
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35784618
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.34479979
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34416813
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34287135
100P53_22387025_ChIP-Seq_ESCs_Mouse1.33656736
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33319834
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32556799
103SPI1_23547873_ChIP-Seq_NB4_Human1.31875755
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.31476582
105IRF1_19129219_ChIP-ChIP_H3396_Human1.30993632
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30796177
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30731354
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.30120220
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29778207
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26312426
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25886948
112GATA3_27048872_Chip-Seq_THYMUS_Human1.25258030
113* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25134629
114SOX2_19829295_ChIP-Seq_ESCs_Human1.22833507
115NANOG_19829295_ChIP-Seq_ESCs_Human1.22833507
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.22765204
117BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22690600
118PU_27001747_Chip-Seq_BMDM_Mouse1.22318128
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20879305
120TCF4_22108803_ChIP-Seq_LS180_Human1.20152297
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20066285
122RUNX2_22187159_ChIP-Seq_PCA_Human1.19472020
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19229055
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19229055
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.19022681
126BP1_19119308_ChIP-ChIP_Hs578T_Human1.18961530
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18214719
128CDX2_22108803_ChIP-Seq_LS180_Human1.17391727
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17183295
130FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17110001
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17018035
132RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16867251
133VDR_24787735_ChIP-Seq_THP-1_Human1.16786184
134HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16472071
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.14600019
136PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13014666
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12362583
138TAL1_26923725_Chip-Seq_HPCs_Mouse1.12258301
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11935644
140TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11693405
141FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11623931
142E2F1_21310950_ChIP-Seq_MCF-7_Human1.10768559
143JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10664205
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09847565
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09847565
146P300_18555785_Chip-Seq_ESCs_Mouse1.09265354
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08846304
148FOXM1_23109430_ChIP-Seq_U2OS_Human1.08097487
149TP53_22573176_ChIP-Seq_HFKS_Human1.07915159
150AR_21572438_ChIP-Seq_LNCaP_Human1.07477148
151EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07410092
152PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06085878
153SMAD4_21741376_ChIP-Seq_EPCs_Human1.06007101
154NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05503544
155GABP_17652178_ChIP-ChIP_JURKAT_Human1.05126091
156PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04209343
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03829272
158HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99001508
159NOTCH1_21737748_ChIP-Seq_TLL_Human0.98993238
160JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93856089
161RUNX1_22412390_ChIP-Seq_EML_Mouse0.93134625
162TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92216202
163MAF_26560356_Chip-Seq_TH1_Human0.90282274
164MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89699889
165TP53_18474530_ChIP-ChIP_U2OS_Human0.89685686
166TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89050335
167HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87979600
168UBF1/2_26484160_Chip-Seq_HMECs_Human0.85705589
169EZH2_27294783_Chip-Seq_NPCs_Mouse0.83115948
170NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83057131
171TCF4_18268006_ChIP-ChIP_LS174T_Human0.82028779
172FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81996581
173RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81428333
174ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81344589
175FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80815676
176STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80772692
177MYC_18555785_ChIP-Seq_MESCs_Mouse0.79755279
178SPI1_23127762_ChIP-Seq_K562_Human0.79534633
179EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78834904
180GATA3_26560356_Chip-Seq_TH2_Human0.78264994
181NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77045711
182TP53_16413492_ChIP-PET_HCT116_Human0.76890858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.37492840
2MP0003787_abnormal_imprinting3.06888088
3MP0008877_abnormal_DNA_methylation2.92675406
4MP0005623_abnormal_meninges_morphology2.72958723
5MP0005671_abnormal_response_to2.69521162
6MP0003195_calcinosis2.58369975
7MP0008438_abnormal_cutaneous_collagen2.47186972
8MP0002837_dystrophic_cardiac_calcinosis2.35637589
9MP0005645_abnormal_hypothalamus_physiol2.34540434
10MP0006054_spinal_hemorrhage2.33270867
11MP0006072_abnormal_retinal_apoptosis2.26309840
12MP0009379_abnormal_foot_pigmentation2.20594636
13MP0002396_abnormal_hematopoietic_system2.19819979
14MP0001986_abnormal_taste_sensitivity2.16310601
15MP0000372_irregular_coat_pigmentation2.14891354
16MP0005551_abnormal_eye_electrophysiolog2.13094786
17MP0002166_altered_tumor_susceptibility2.10745756
18MP0000427_abnormal_hair_cycle2.10618063
19MP0010352_gastrointestinal_tract_polyps2.08967461
20MP0001835_abnormal_antigen_presentation2.08943313
21MP0005503_abnormal_tendon_morphology2.07735510
22MP0001984_abnormal_olfaction2.05821190
23MP0001879_abnormal_lymphatic_vessel1.96110578
24MP0002006_tumorigenesis1.94721368
25MP0008007_abnormal_cellular_replicative1.92985094
26MP0001873_stomach_inflammation1.91134833
27MP0005253_abnormal_eye_physiology1.90794894
28MP0009046_muscle_twitch1.87385381
29MP0008057_abnormal_DNA_replication1.87214915
30MP0004272_abnormal_basement_membrane1.87134320
31MP0003279_aneurysm1.82959068
32MP0004808_abnormal_hematopoietic_stem1.79766333
33MP0010386_abnormal_urinary_bladder1.78222647
34MP0002638_abnormal_pupillary_reflex1.76995830
35MP0002009_preneoplasia1.75947495
36MP0000685_abnormal_immune_system1.74608485
37MP0005387_immune_system_phenotype1.74266179
38MP0001790_abnormal_immune_system1.74266179
39MP0000569_abnormal_digit_pigmentation1.72180569
40MP0005379_endocrine/exocrine_gland_phen1.71545407
41MP0003566_abnormal_cell_adhesion1.69021939
42MP0005076_abnormal_cell_differentiation1.68849630
43MP0003121_genomic_imprinting1.67946301
44MP0003091_abnormal_cell_migration1.66131446
45MP0002163_abnormal_gland_morphology1.59989084
46MP0010368_abnormal_lymphatic_system1.59545041
47MP0003724_increased_susceptibility_to1.59269872
48MP0010307_abnormal_tumor_latency1.57563217
49MP0003880_abnormal_central_pattern1.56775897
50MP0000383_abnormal_hair_follicle1.53826332
51MP0003252_abnormal_bile_duct1.48520166
52MP0002876_abnormal_thyroid_physiology1.47263649
53MP0004142_abnormal_muscle_tone1.46458527
54MP0008004_abnormal_stomach_pH1.46136391
55MP0004215_abnormal_myocardial_fiber1.44200237
56MP0005084_abnormal_gallbladder_morpholo1.43661063
57MP0002148_abnormal_hypersensitivity_rea1.43001154
58MP0003300_gastrointestinal_ulcer1.41982585
59MP0005410_abnormal_fertilization1.41486099
60MP0001501_abnormal_sleep_pattern1.41378931
61MP0005397_hematopoietic_system_phenotyp1.39648284
62MP0001545_abnormal_hematopoietic_system1.39648284
63MP0005187_abnormal_penis_morphology1.39480144
64MP0008775_abnormal_heart_ventricle1.38932404
65MP0001958_emphysema1.37188590
66MP0003436_decreased_susceptibility_to1.36904235
67MP0009785_altered_susceptibility_to1.36151860
68MP0005023_abnormal_wound_healing1.35596590
69MP0002877_abnormal_melanocyte_morpholog1.34227039
70MP0002933_joint_inflammation1.33686402
71MP0002938_white_spotting1.30341435
72MP0002452_abnormal_antigen_presenting1.29608076
73MP0006276_abnormal_autonomic_nervous1.29585166
74MP0009384_cardiac_valve_regurgitation1.28168193
75MP0000733_abnormal_muscle_development1.26788129
76MP0005000_abnormal_immune_tolerance1.26462573
77MP0002405_respiratory_system_inflammati1.24313909
78MP0005646_abnormal_pituitary_gland1.24047360
79MP0002420_abnormal_adaptive_immunity1.23432198
80MP0001819_abnormal_immune_cell1.22716545
81MP0003943_abnormal_hepatobiliary_system1.21199943
82MP0001915_intracranial_hemorrhage1.20351592
83MP0004924_abnormal_behavior1.19600162
84MP0005386_behavior/neurological_phenoty1.19600162
85MP0004147_increased_porphyrin_level1.19211532
86MP0002160_abnormal_reproductive_system1.18891070
87MP0002095_abnormal_skin_pigmentation1.18180668
88MP0010094_abnormal_chromosome_stability1.17078187
89MP0002928_abnormal_bile_duct1.16382163
90MP0002723_abnormal_immune_serum1.16158081
91MP0010678_abnormal_skin_adnexa1.14521341
92MP0004145_abnormal_muscle_electrophysio1.13322844
93MP0002398_abnormal_bone_marrow1.13165423
94MP0002419_abnormal_innate_immunity1.13027896
95MP0003950_abnormal_plasma_membrane1.12506570
96MP0001800_abnormal_humoral_immune1.12502474
97MP0001533_abnormal_skeleton_physiology1.12439436
98MP0002272_abnormal_nervous_system1.11821834
99MP0005171_absent_coat_pigmentation1.11638376
100MP0009333_abnormal_splenocyte_physiolog1.11286145
101MP0000490_abnormal_crypts_of1.10914171
102MP0001529_abnormal_vocalization1.10643171
103MP0001968_abnormal_touch/_nociception1.09820856
104MP0001486_abnormal_startle_reflex1.09034211
105MP0003448_altered_tumor_morphology1.08999882
106MP0000767_abnormal_smooth_muscle1.08770173
107MP0000858_altered_metastatic_potential1.07920438
108MP0000015_abnormal_ear_pigmentation1.07772500
109MP0005075_abnormal_melanosome_morpholog1.07163057
110MP0003646_muscle_fatigue1.06288425
111MP0005025_abnormal_response_to1.05320514
112MP0002282_abnormal_trachea_morphology1.04983793
113MP0004043_abnormal_pH_regulation1.04604921
114MP0000716_abnormal_immune_system1.04545823
115* MP0008058_abnormal_DNA_repair1.03845361
116MP0008872_abnormal_physiological_respon1.03694480
117MP0001919_abnormal_reproductive_system1.03637285
118MP0000465_gastrointestinal_hemorrhage1.03636592
119MP0004484_altered_response_of1.03116098
120MP0002234_abnormal_pharynx_morphology1.01556270
121MP0009278_abnormal_bone_marrow1.01256071
122MP0010155_abnormal_intestine_physiology1.00434707
123MP0005174_abnormal_tail_pigmentation0.98904497
124MP0004885_abnormal_endolymph0.98842172
125MP0005275_abnormal_skin_tensile0.97238145
126MP0003763_abnormal_thymus_physiology0.97180573
127MP0004133_heterotaxia0.96730272
128MP0002295_abnormal_pulmonary_circulatio0.96529014
129MP0005167_abnormal_blood-brain_barrier0.96463208
130MP0003122_maternal_imprinting0.96127228
131MP0009745_abnormal_behavioral_response0.96030596
132MP0000013_abnormal_adipose_tissue0.96029355
133MP0001542_abnormal_bone_strength0.95703798
134MP0002722_abnormal_immune_system0.92615402
135MP0003045_fibrosis0.92511980
136MP0005266_abnormal_metabolism0.92284200
137MP0002998_abnormal_bone_remodeling0.92140637
138MP0008995_early_reproductive_senescence0.91960290
139MP0004084_abnormal_cardiac_muscle0.91786344
140MP0000689_abnormal_spleen_morphology0.90174122
141MP0003941_abnormal_skin_development0.89507116
142MP0002429_abnormal_blood_cell0.88999916
143MP0002067_abnormal_sensory_capabilities0.88684410
144MP0000631_abnormal_neuroendocrine_gland0.87991540
145MP0005164_abnormal_response_to0.87817022
146MP0005408_hypopigmentation0.87744312
147MP0005390_skeleton_phenotype0.86669056
148MP0003011_delayed_dark_adaptation0.86180828
149MP0003705_abnormal_hypodermis_morpholog0.86066624
150MP0002693_abnormal_pancreas_physiology0.84511327
151MP0002735_abnormal_chemical_nociception0.83725886
152MP0000230_abnormal_systemic_arterial0.83408198
153MP0009697_abnormal_copulation0.82658021
154MP0000647_abnormal_sebaceous_gland0.82339149
155MP0004957_abnormal_blastocyst_morpholog0.81506462
156MP0003656_abnormal_erythrocyte_physiolo0.81351331
157MP0003633_abnormal_nervous_system0.81348963
158MP0004134_abnormal_chest_morphology0.81088900
159MP0003077_abnormal_cell_cycle0.80793056
160MP0002557_abnormal_social/conspecific_i0.79719579
161MP0002138_abnormal_hepatobiliary_system0.79659998
162MP0005220_abnormal_exocrine_pancreas0.79581037
163MP0002909_abnormal_adrenal_gland0.79431835
164MP0003890_abnormal_embryonic-extraembry0.78929833
165MP0002019_abnormal_tumor_incidence0.78896769
166MP0002086_abnormal_extraembryonic_tissu0.78861951
167MP0002925_abnormal_cardiovascular_devel0.78831668
168MP0005508_abnormal_skeleton_morphology0.78233684
169MP0001243_abnormal_dermal_layer0.78191055
170MP0005464_abnormal_platelet_physiology0.77371369
171MP0003718_maternal_effect0.77276965
172MP0001853_heart_inflammation0.76573299
173MP0005195_abnormal_posterior_eye0.76402253
174MP0003795_abnormal_bone_structure0.76220138
175MP0001324_abnormal_eye_pigmentation0.75376864
176MP0001929_abnormal_gametogenesis0.75284787
177MP0005367_renal/urinary_system_phenotyp0.74884407
178MP0000516_abnormal_urinary_system0.74884407
179MP0005389_reproductive_system_phenotype0.74407653
180MP0000350_abnormal_cell_proliferation0.74319439
181MP0008875_abnormal_xenobiotic_pharmacok0.71931528
182MP0006292_abnormal_olfactory_placode0.71475724
183MP0002572_abnormal_emotion/affect_behav0.70390050
184MP0005647_abnormal_sex_gland0.66829948
185MP0000371_diluted_coat_color0.66828728

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.56274508
2Pancreatic cysts (HP:0001737)4.02722482
3Abnormal respiratory motile cilium physiology (HP:0012261)3.88628960
4Pancreatic fibrosis (HP:0100732)3.88588428
5Medial flaring of the eyebrow (HP:0010747)3.79413481
6Molar tooth sign on MRI (HP:0002419)3.77131137
7Abnormality of midbrain morphology (HP:0002418)3.77131137
8Nephronophthisis (HP:0000090)3.64607060
9Hyperventilation (HP:0002883)3.63593549
10Abnormality of the renal cortex (HP:0011035)3.44627175
11Rhinitis (HP:0012384)3.40636165
12Renal cortical cysts (HP:0000803)3.36260082
13Abnormality of the renal medulla (HP:0100957)3.25702252
14Abnormal ciliary motility (HP:0012262)3.24289590
15Congenital primary aphakia (HP:0007707)3.18592953
16Gait imbalance (HP:0002141)3.18214597
17Retrobulbar optic neuritis (HP:0100654)3.17949741
18Optic neuritis (HP:0100653)3.17949741
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.16989771
20Absent/shortened dynein arms (HP:0200106)3.16989771
21Abnormal respiratory epithelium morphology (HP:0012253)3.16918587
22Abnormal respiratory motile cilium morphology (HP:0005938)3.16918587
23Premature rupture of membranes (HP:0001788)3.08138139
24Type II lissencephaly (HP:0007260)3.01855214
25Abnormality of the nasal mucosa (HP:0000433)2.97855005
26Abnormality of dentin (HP:0010299)2.95770979
27Nephrogenic diabetes insipidus (HP:0009806)2.90802300
28Large for gestational age (HP:0001520)2.89665697
29Nasal polyposis (HP:0100582)2.87072487
30Chronic hepatic failure (HP:0100626)2.83165790
31Volvulus (HP:0002580)2.82974518
32Abdominal situs inversus (HP:0003363)2.82397314
33Abnormality of abdominal situs (HP:0011620)2.82397314
34Thrombocytosis (HP:0001894)2.81303314
35Myositis (HP:0100614)2.79416083
36Fair hair (HP:0002286)2.76077576
37Congenital stationary night blindness (HP:0007642)2.75387319
38Thyroiditis (HP:0100646)2.71476694
39Orchitis (HP:0100796)2.65562319
40Short nail (HP:0001799)2.65444247
41Chronic bronchitis (HP:0004469)2.59451254
42Widely spaced teeth (HP:0000687)2.58883178
43Protruding tongue (HP:0010808)2.57771381
44Methylmalonic acidemia (HP:0002912)2.56659820
45Hypothermia (HP:0002045)2.53811050
46Supernumerary spleens (HP:0009799)2.53001833
47Genetic anticipation (HP:0003743)2.50960250
48Protrusio acetabuli (HP:0003179)2.49872583
49Gaze-evoked nystagmus (HP:0000640)2.49347905
50Cervical subluxation (HP:0003308)2.49113171
51Genital tract atresia (HP:0001827)2.48324801
52Drooling (HP:0002307)2.45453281
53Spontaneous hematomas (HP:0007420)2.44986968
54Aortic aneurysm (HP:0004942)2.44045900
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.43702316
56Asplenia (HP:0001746)2.43702156
57Mesomelia (HP:0003027)2.42085842
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.41301859
59Attenuation of retinal blood vessels (HP:0007843)2.38263768
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.37001060
61Acute myeloid leukemia (HP:0004808)2.36835054
62Male infertility (HP:0003251)2.33169278
63Aortic dissection (HP:0002647)2.31760494
64Absent speech (HP:0001344)2.30768494
65Poor coordination (HP:0002370)2.30172730
66Vaginal atresia (HP:0000148)2.28414828
6711 pairs of ribs (HP:0000878)2.27840666
68Cystic liver disease (HP:0006706)2.27826593
69Cerebellar dysplasia (HP:0007033)2.27823325
70Tubular atrophy (HP:0000092)2.27718816
71Abolished electroretinogram (ERG) (HP:0000550)2.26206074
72Absent frontal sinuses (HP:0002688)2.23703383
73Bronchiectasis (HP:0002110)2.23615043
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23400005
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.23400005
76Ketoacidosis (HP:0001993)2.23032926
77Spinal cord lesions (HP:0100561)2.20943143
78Syringomyelia (HP:0003396)2.20943143
79Excessive salivation (HP:0003781)2.20435488
80Broad-based gait (HP:0002136)2.19024887
81Keratoconus (HP:0000563)2.18750866
82Increased corneal curvature (HP:0100692)2.18750866
83Vascular tortuosity (HP:0004948)2.14757299
84Congenital hepatic fibrosis (HP:0002612)2.14425452
85Hematochezia (HP:0002573)2.13507846
86Generalized hypopigmentation of hair (HP:0011358)2.13145602
87Hemiparesis (HP:0001269)2.12135930
88Lissencephaly (HP:0001339)2.11620879
89Broad face (HP:0000283)2.09475252
90Tubulointerstitial nephritis (HP:0001970)2.07305227
91Arterial thrombosis (HP:0004420)2.03008455
92Bile duct proliferation (HP:0001408)2.01664802
93Abnormal biliary tract physiology (HP:0012439)2.01664802
94Hypoplasia of the fovea (HP:0007750)2.00870495
95Aplasia/Hypoplasia of the fovea (HP:0008060)2.00870495
96Intestinal atresia (HP:0011100)2.00124112
973-Methylglutaconic aciduria (HP:0003535)1.99244640
98Bronchitis (HP:0012387)1.97726446
99Epiphyseal dysplasia (HP:0002656)1.97575438
100Chronic otitis media (HP:0000389)1.97439360
101Abnormality of vitamin B metabolism (HP:0004340)1.97192661
102Progressive macrocephaly (HP:0004481)1.96424666
103Furrowed tongue (HP:0000221)1.96289293
104Febrile seizures (HP:0002373)1.95647504
105Sclerocornea (HP:0000647)1.94398804
106Postaxial hand polydactyly (HP:0001162)1.94045508
107Stomach cancer (HP:0012126)1.93977747
108Hypoplastic ischia (HP:0003175)1.93711822
109Abnormality of the fovea (HP:0000493)1.92791803
110Short humerus (HP:0005792)1.92484699
111Anencephaly (HP:0002323)1.91545030
112Short tibia (HP:0005736)1.91250501
113Postaxial foot polydactyly (HP:0001830)1.90752173
114Metaphyseal dysplasia (HP:0100255)1.90013960
115Limited elbow extension (HP:0001377)1.89061687
116Abnormal rod and cone electroretinograms (HP:0008323)1.87540481
117Entropion (HP:0000621)1.86608156
118Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86468902
119Male pseudohermaphroditism (HP:0000037)1.85269246
120Inability to walk (HP:0002540)1.84517354
121Astigmatism (HP:0000483)1.84356536
122Occipital encephalocele (HP:0002085)1.83651083
123Methylmalonic aciduria (HP:0012120)1.81881406
124Hypoplastic iliac wings (HP:0002866)1.81857400
125Aplasia/Hypoplasia of the lens (HP:0008063)1.81728835
126Pachygyria (HP:0001302)1.81648248
127Polydipsia (HP:0001959)1.81172679
128Abnormal drinking behavior (HP:0030082)1.81172679
129Abnormality of the nasal septum (HP:0000419)1.81165244
130Cerebral aneurysm (HP:0004944)1.81079404
131Arterial tortuosity (HP:0005116)1.78348905
132Increased CSF lactate (HP:0002490)1.78120143
133Long eyelashes (HP:0000527)1.78083904
134Progressive inability to walk (HP:0002505)1.77967644
135Atrophic scars (HP:0001075)1.77911548
136Deviation of the thumb (HP:0009603)1.77591889
137Broad foot (HP:0001769)1.77511832
138Short foot (HP:0001773)1.77429821
139Portal hypertension (HP:0001409)1.76869458
140Thyroid carcinoma (HP:0002890)1.76157658
141Papillary thyroid carcinoma (HP:0002895)1.75718302
142Radial bowing (HP:0002986)1.74979129
143Progressive cerebellar ataxia (HP:0002073)1.74740063
144Spinal rigidity (HP:0003306)1.74549644
145Small hand (HP:0200055)1.73680141
146Aplasia/hypoplasia of the humerus (HP:0006507)1.72463777
147Pulmonary infiltrates (HP:0002113)1.72461889
148Neoplasm of the adrenal cortex (HP:0100641)1.72371870
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.71521417
150Osteolytic defects of the hand bones (HP:0009699)1.71521417
151True hermaphroditism (HP:0010459)1.71007369
152Prominent nasal bridge (HP:0000426)1.70765992
153Mitochondrial inheritance (HP:0001427)1.69889745
154Abnormality of the fingertips (HP:0001211)1.69858414
155Abnormality of the vitamin B12 metabolism (HP:0004341)1.69130920
156Acute necrotizing encephalopathy (HP:0006965)1.68915321
157Bell-shaped thorax (HP:0001591)1.68718278
158Ketosis (HP:0001946)1.68482173
159Disproportionate short-trunk short stature (HP:0003521)1.68472637
160Abnormality of the pons (HP:0007361)1.68340766
161Tubulointerstitial abnormality (HP:0001969)1.68045085
162Abnormality of the calcaneus (HP:0008364)1.66778697
163Dilatation of the ascending aorta (HP:0005111)1.66761169
164Colon cancer (HP:0003003)1.65735078
165Vertebral hypoplasia (HP:0008417)1.64977258
166Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.64977258
167Optic nerve hypoplasia (HP:0000609)1.64554424
168Thyroid-stimulating hormone excess (HP:0002925)1.64402998
169Lipid accumulation in hepatocytes (HP:0006561)1.63527353
170Hyperalaninemia (HP:0003348)1.63509532
171Stillbirth (HP:0003826)1.61690094
172Abnormality of the hepatic vasculature (HP:0006707)1.61374091
173Spondylolisthesis (HP:0003302)1.61287436
174Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60392554
175Decreased skull ossification (HP:0004331)1.60157641
176Neonatal short-limb short stature (HP:0008921)1.59329254
177Persistence of primary teeth (HP:0006335)1.57110563
178Abnormality of T cell number (HP:0011839)1.57089829
179Missing ribs (HP:0000921)1.56697385
180Recurrent bronchitis (HP:0002837)1.56576574
181Abnormality of the acetabulum (HP:0003170)1.56400314
182Keratoconjunctivitis sicca (HP:0001097)1.55642499
183Submucous cleft hard palate (HP:0000176)1.55507658
184Abnormality of the ischium (HP:0003174)1.54122547
185Chronic sinusitis (HP:0011109)1.53832244
186Infertility (HP:0000789)1.53411390
187Shallow orbits (HP:0000586)1.52273927
188Cone-rod dystrophy (HP:0000548)1.52162072
189White forelock (HP:0002211)1.51548660
190Wormian bones (HP:0002645)1.51367395
191Abnormality of the pericardium (HP:0001697)1.50838420
192Abnormality of the frontal sinuses (HP:0002687)1.50529114
193Subacute progressive viral hepatitis (HP:0006572)1.50240463
194Breech presentation (HP:0001623)1.49792183
195Abnormality of the peritoneum (HP:0002585)1.49426855
196Abnormality of skull ossification (HP:0002703)1.49344943
197Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.47459019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM23.25345081
2BMPR1B3.04267294
3SCYL22.85624744
4WNK32.66063713
5MAP4K22.56498927
6CASK2.56105334
7FRK2.42029953
8TGFBR22.21337731
9TIE12.20337529
10TAOK32.15393955
11MAP3K142.14089145
12TGFBR12.04452236
13STK32.01313801
14TESK12.00638245
15NUAK11.93699550
16MAP3K41.91737775
17JAK31.91471027
18TRIM281.90873984
19MAPK131.83480070
20TXK1.78064301
21TLK11.76725816
22TNIK1.75628468
23PINK11.73794593
24ADRBK21.72497557
25EPHA31.70343328
26SIK31.67491412
27NEK91.67408772
28GRK11.66531444
29PIM11.65623221
30EPHA21.62135193
31STK101.60422611
32KIT1.59668340
33ACVR1B1.58764462
34TEC1.58056046
35CDK121.57645575
36MAP3K31.52414343
37PTK2B1.50926848
38PAK41.49629464
39PLK21.47942933
40TRPM71.44756089
41STK391.44711442
42EEF2K1.43871830
43CDK61.42605961
44MST41.38362004
45IKBKB1.37783758
46ERBB31.30827023
47RPS6KB21.30362260
48STK38L1.24773968
49KDR1.23987989
50PAK31.19749311
51INSRR1.19184116
52CHUK1.19121081
53OXSR11.18161651
54TBK11.17952622
55BMX1.16766975
56PAK21.15703270
57FLT31.13066938
58TTN1.10767385
59MAP4K11.09409450
60MET1.07791632
61LRRK21.06941453
62NLK1.06814346
63CAMKK21.05221554
64DDR21.03369670
65OBSCN1.03218341
66MKNK11.02879799
67ZAK1.02519414
68MARK31.01707856
69BMPR21.00814877
70CSF1R0.99715749
71PNCK0.98720609
72BCR0.95492533
73EPHB10.94581638
74PRKCE0.94509572
75ITK0.93896142
76PIK3CG0.93871600
77CCNB10.92938755
78CSNK1G10.92801228
79CSNK1G20.91409942
80CSK0.91321962
81MKNK20.89593915
82CSNK1A1L0.88972334
83PRKG20.88899233
84CAMK1D0.88390910
85DMPK0.87173953
86TSSK60.87156082
87PTK60.86756864
88IRAK10.85667142
89STK40.85097672
90LATS10.84482746
91ADRBK10.82243128
92PDK20.81651085
93NEK60.80178343
94RPS6KA40.79419641
95MAP2K70.79102340
96EIF2AK30.78456644
97FER0.78322126
98CSNK1G30.77558194
99SGK20.75506037
100PLK40.75483776
101FGFR20.75374342
102JAK10.72784835
103EIF2AK20.72527904
104PTK20.71885004
105DYRK1B0.71857740
106AKT30.71846271
107BRD40.71689413
108MAP2K30.71087884
109GRK70.70140243
110BTK0.69279377
111SRPK10.68737908
112MARK10.68501046
113SIK10.67384905
114NTRK30.67270055
115DAPK20.67056090
116BCKDK0.66878442
117PHKG10.65145626
118PHKG20.65145626
119GSK3A0.64493044
120INSR0.63827072
121PIK3CA0.63760780
122PASK0.63254817
123LIMK10.62907130
124VRK10.61436638
125RIPK10.59247782
126MAPKAPK20.59079433
127WNK40.57615019
128PLK30.57442385
129NME20.57436089
130ABL10.56820779
131LCK0.54819866
132BRSK20.53284163
133NEK10.52655618
134SYK0.51113642
135CAMK1G0.50950394
136PDGFRB0.50901371
137PRKCQ0.49980060
138CDK90.49854562
139CDK40.49850028
140CDK70.48384973
141ATM0.47290735
142IKBKE0.47218509
143IRAK40.47009653
144YES10.46329666
145ATR0.46075941
146CDC70.46032205
147EGFR0.44676034
148MUSK0.44141790
149CAMK2A0.43270010
150MAP3K20.37886076
151WEE10.37848908
152CSNK1D0.37211635
153RPS6KA50.36278508
154PRKAA20.35064262
155PKN10.34930939
156DYRK1A0.33751258
157PRKACB0.33084036
158MAP3K120.31352968
159PRKG10.30957459
160PRKCG0.29993071
161IGF1R0.29336093

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.37220656
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90792624
3Phototransduction_Homo sapiens_hsa047442.74894343
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.69043344
5Butanoate metabolism_Homo sapiens_hsa006502.60103964
6Circadian rhythm_Homo sapiens_hsa047102.39456216
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.34820034
8p53 signaling pathway_Homo sapiens_hsa041152.07358321
9Nitrogen metabolism_Homo sapiens_hsa009102.02698560
10Malaria_Homo sapiens_hsa051441.98937206
11Graft-versus-host disease_Homo sapiens_hsa053321.97995142
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.97158565
13Propanoate metabolism_Homo sapiens_hsa006401.95900255
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95550595
15Allograft rejection_Homo sapiens_hsa053301.92870494
16Antigen processing and presentation_Homo sapiens_hsa046121.79819871
17Small cell lung cancer_Homo sapiens_hsa052221.76395819
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74299265
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.73922049
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73413425
21ECM-receptor interaction_Homo sapiens_hsa045121.70289314
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69675624
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68282373
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66839799
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65656294
26Non-homologous end-joining_Homo sapiens_hsa034501.65487999
27Adherens junction_Homo sapiens_hsa045201.64629775
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.64343860
29ABC transporters_Homo sapiens_hsa020101.63504009
30Regulation of autophagy_Homo sapiens_hsa041401.62833452
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57366350
32Measles_Homo sapiens_hsa051621.54216363
33Focal adhesion_Homo sapiens_hsa045101.53889152
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52915995
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.48813747
36Ether lipid metabolism_Homo sapiens_hsa005651.46379949
37Hematopoietic cell lineage_Homo sapiens_hsa046401.45274067
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44478138
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.44117146
40Linoleic acid metabolism_Homo sapiens_hsa005911.42141647
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41682086
42Oxidative phosphorylation_Homo sapiens_hsa001901.41165048
43Selenocompound metabolism_Homo sapiens_hsa004501.39057263
44Cell cycle_Homo sapiens_hsa041101.38509831
45Peroxisome_Homo sapiens_hsa041461.35945337
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.33226921
47MicroRNAs in cancer_Homo sapiens_hsa052061.32723590
48Leishmaniasis_Homo sapiens_hsa051401.30903819
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30748036
50Shigellosis_Homo sapiens_hsa051311.29799124
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29419784
52Legionellosis_Homo sapiens_hsa051341.29017192
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.28160803
54Viral myocarditis_Homo sapiens_hsa054161.28056155
55TGF-beta signaling pathway_Homo sapiens_hsa043501.27310803
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27283056
57Proteoglycans in cancer_Homo sapiens_hsa052051.26748333
58Nucleotide excision repair_Homo sapiens_hsa034201.26697366
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25533860
60Toxoplasmosis_Homo sapiens_hsa051451.24937021
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24582912
62Dorso-ventral axis formation_Homo sapiens_hsa043201.24240752
63Apoptosis_Homo sapiens_hsa042101.23530807
64Hepatitis B_Homo sapiens_hsa051611.23176384
65Rheumatoid arthritis_Homo sapiens_hsa053231.22364658
66Autoimmune thyroid disease_Homo sapiens_hsa053201.22254777
67Primary immunodeficiency_Homo sapiens_hsa053401.19222525
68One carbon pool by folate_Homo sapiens_hsa006701.18815811
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18543297
70Viral carcinogenesis_Homo sapiens_hsa052031.18006342
71Tryptophan metabolism_Homo sapiens_hsa003801.16263428
72Olfactory transduction_Homo sapiens_hsa047401.15852905
73Amoebiasis_Homo sapiens_hsa051461.14148396
74TNF signaling pathway_Homo sapiens_hsa046681.12004008
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10897147
76Taste transduction_Homo sapiens_hsa047421.10845798
77Prostate cancer_Homo sapiens_hsa052151.10484907
78DNA replication_Homo sapiens_hsa030301.09667443
79HTLV-I infection_Homo sapiens_hsa051661.08221658
80Chronic myeloid leukemia_Homo sapiens_hsa052201.07652973
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07041667
82Hippo signaling pathway_Homo sapiens_hsa043901.06500792
83Homologous recombination_Homo sapiens_hsa034401.05426076
84Base excision repair_Homo sapiens_hsa034101.03095816
85PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01086055
86Insulin secretion_Homo sapiens_hsa049111.00191465
87RNA transport_Homo sapiens_hsa030130.98574335
88RNA polymerase_Homo sapiens_hsa030200.98023011
89Caffeine metabolism_Homo sapiens_hsa002320.97857742
90B cell receptor signaling pathway_Homo sapiens_hsa046620.97343857
91Herpes simplex infection_Homo sapiens_hsa051680.97316489
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.96691983
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95071849
94Nicotine addiction_Homo sapiens_hsa050330.94896878
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94034914
96Systemic lupus erythematosus_Homo sapiens_hsa053220.92877851
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92672221
98Epstein-Barr virus infection_Homo sapiens_hsa051690.92253214
99Salmonella infection_Homo sapiens_hsa051320.92166659
100RNA degradation_Homo sapiens_hsa030180.91739808
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90399061
102Basal transcription factors_Homo sapiens_hsa030220.89209253
103* Fanconi anemia pathway_Homo sapiens_hsa034600.88776417
104Circadian entrainment_Homo sapiens_hsa047130.88466378
105Morphine addiction_Homo sapiens_hsa050320.87064660
106T cell receptor signaling pathway_Homo sapiens_hsa046600.86327650
107Pathways in cancer_Homo sapiens_hsa052000.83983498
108Serotonergic synapse_Homo sapiens_hsa047260.83901325
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82440368
110Salivary secretion_Homo sapiens_hsa049700.82371433
111Parkinsons disease_Homo sapiens_hsa050120.81788444
112Steroid biosynthesis_Homo sapiens_hsa001000.81091771
113Mismatch repair_Homo sapiens_hsa034300.79407702
114Platelet activation_Homo sapiens_hsa046110.79150607
115Glutamatergic synapse_Homo sapiens_hsa047240.78953806
116Pancreatic cancer_Homo sapiens_hsa052120.78723354
117Pertussis_Homo sapiens_hsa051330.77849877
118Osteoclast differentiation_Homo sapiens_hsa043800.76642058
119Collecting duct acid secretion_Homo sapiens_hsa049660.76472569
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76347681
121Influenza A_Homo sapiens_hsa051640.76337427
122Melanoma_Homo sapiens_hsa052180.76030224
123HIF-1 signaling pathway_Homo sapiens_hsa040660.75901979
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75770142
125Chemokine signaling pathway_Homo sapiens_hsa040620.75013607
126Renin secretion_Homo sapiens_hsa049240.74821241
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74153419
128Ribosome_Homo sapiens_hsa030100.73094111
129GABAergic synapse_Homo sapiens_hsa047270.73065933
130Proteasome_Homo sapiens_hsa030500.70609685
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70345522
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69551837
133Purine metabolism_Homo sapiens_hsa002300.69474450
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68867880
135Asthma_Homo sapiens_hsa053100.67803054
136Fatty acid elongation_Homo sapiens_hsa000620.67511626
137Tight junction_Homo sapiens_hsa045300.65869289
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65403428
139Phagosome_Homo sapiens_hsa041450.64850289
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64515916
141Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63421126
142Type I diabetes mellitus_Homo sapiens_hsa049400.60715188
143Rap1 signaling pathway_Homo sapiens_hsa040150.60593018
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59942734
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59287444
146Alzheimers disease_Homo sapiens_hsa050100.57345669
147Tuberculosis_Homo sapiens_hsa051520.57241918
148Sulfur metabolism_Homo sapiens_hsa009200.57211108
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56701702
150Ovarian steroidogenesis_Homo sapiens_hsa049130.56147018
151Calcium signaling pathway_Homo sapiens_hsa040200.55027369
152Hepatitis C_Homo sapiens_hsa051600.54785944
153Renal cell carcinoma_Homo sapiens_hsa052110.53303707
154Spliceosome_Homo sapiens_hsa030400.52637485
155Dopaminergic synapse_Homo sapiens_hsa047280.52157756
156Acute myeloid leukemia_Homo sapiens_hsa052210.50765375
157Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50675086
158Chemical carcinogenesis_Homo sapiens_hsa052040.50559072
159Retinol metabolism_Homo sapiens_hsa008300.49045558
160Arachidonic acid metabolism_Homo sapiens_hsa005900.46427254
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.46253911
162Notch signaling pathway_Homo sapiens_hsa043300.45989043
163Bladder cancer_Homo sapiens_hsa052190.45668105
164Oxytocin signaling pathway_Homo sapiens_hsa049210.41456395
165Amphetamine addiction_Homo sapiens_hsa050310.40811535
166Long-term depression_Homo sapiens_hsa047300.39689161
167beta-Alanine metabolism_Homo sapiens_hsa004100.35524885
168Huntingtons disease_Homo sapiens_hsa050160.35207620
169Oocyte meiosis_Homo sapiens_hsa041140.32614084
170Pancreatic secretion_Homo sapiens_hsa049720.32248548
171Fatty acid metabolism_Homo sapiens_hsa012120.30230681
172Type II diabetes mellitus_Homo sapiens_hsa049300.29909220
173Metabolic pathways_Homo sapiens_hsa011000.29821495

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