POLL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.01994417
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.99572891
3negative regulation of cell killing (GO:0031342)4.99572891
4DNA strand elongation (GO:0022616)4.90623532
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.85504943
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.85504943
7modulation by symbiont of host immune response (GO:0052553)4.85504943
8positive regulation by symbiont of host defense response (GO:0052509)4.85504943
9modulation by symbiont of host defense response (GO:0052031)4.85504943
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.85504943
11DNA deamination (GO:0045006)4.81054531
12ribosomal small subunit assembly (GO:0000028)4.76330908
13telomere maintenance via semi-conservative replication (GO:0032201)4.72334516
14DNA unwinding involved in DNA replication (GO:0006268)4.43906004
15DNA replication initiation (GO:0006270)4.42959252
16positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.35740819
173-UTR-mediated mRNA stabilization (GO:0070935)4.25458387
18modulation by virus of host process (GO:0019054)4.24613458
19negative regulation of erythrocyte differentiation (GO:0045647)4.19719893
20nucleobase biosynthetic process (GO:0046112)4.03442289
21purine nucleobase biosynthetic process (GO:0009113)3.99698153
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98929032
23telomere maintenance via recombination (GO:0000722)3.91979959
24antigen processing and presentation of endogenous antigen (GO:0019883)3.88662126
25GDP-mannose metabolic process (GO:0019673)3.84300280
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.82380525
27mannose metabolic process (GO:0006013)3.78460471
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.78417643
29DNA replication checkpoint (GO:0000076)3.77737402
30neutrophil activation involved in immune response (GO:0002283)3.74655223
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.73163120
32histone H4 deacetylation (GO:0070933)3.68701674
33modulation by symbiont of host cellular process (GO:0044068)3.64045136
34snRNA processing (GO:0016180)3.62765168
35telomere maintenance via telomere lengthening (GO:0010833)3.61668110
36mitotic recombination (GO:0006312)3.58758348
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.55041117
38response to peptidoglycan (GO:0032494)3.50777497
39IMP biosynthetic process (GO:0006188)3.49250414
40protoporphyrinogen IX metabolic process (GO:0046501)3.48826875
41binding of sperm to zona pellucida (GO:0007339)3.47527245
42oxygen transport (GO:0015671)3.47008809
43sperm-egg recognition (GO:0035036)3.44662240
44phosphatidylglycerol biosynthetic process (GO:0006655)3.43812347
45detection of bacterium (GO:0016045)3.41016822
46macrophage activation involved in immune response (GO:0002281)3.37994702
47cellular response to virus (GO:0098586)3.37475858
48snRNA metabolic process (GO:0016073)3.36821972
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.33650288
50regulation of mitotic spindle checkpoint (GO:1903504)3.33650288
51regulation of spindle checkpoint (GO:0090231)3.33592424
52regulation of mast cell degranulation (GO:0043304)3.31514693
53positive regulation of gamma-delta T cell activation (GO:0046645)3.31318418
54NIK/NF-kappaB signaling (GO:0038061)3.31019785
55response to host immune response (GO:0052572)3.29741070
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29741070
57CENP-A containing nucleosome assembly (GO:0034080)3.29445913
58IMP metabolic process (GO:0046040)3.29266015
59chromatin remodeling at centromere (GO:0031055)3.26746059
60viral mRNA export from host cell nucleus (GO:0046784)3.25367684
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.23436300
62negative regulation of cAMP-mediated signaling (GO:0043951)3.22727177
63protein localization to chromosome, centromeric region (GO:0071459)3.22463535
64viral protein processing (GO:0019082)3.22219120
65negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.21457436
66formation of translation preinitiation complex (GO:0001731)3.20218424
67regulation of gamma-delta T cell activation (GO:0046643)3.19491621
68intracellular estrogen receptor signaling pathway (GO:0030520)3.19405409
69detection of other organism (GO:0098543)3.18641414
70maturation of SSU-rRNA (GO:0030490)3.17731603
71leukocyte aggregation (GO:0070486)3.17045972
72DNA replication-dependent nucleosome organization (GO:0034723)3.08983075
73DNA replication-dependent nucleosome assembly (GO:0006335)3.08983075
74regulation of myeloid leukocyte mediated immunity (GO:0002886)3.08131099
75DNA replication-independent nucleosome assembly (GO:0006336)3.06614117
76DNA replication-independent nucleosome organization (GO:0034724)3.06614117
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06058124
78folic acid-containing compound biosynthetic process (GO:0009396)3.05752215
79ribosome biogenesis (GO:0042254)3.05077310
80cell-cell recognition (GO:0009988)3.05073731
81regulation of chromatin binding (GO:0035561)3.04416900
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04233834
83neutrophil activation (GO:0042119)3.04123373
84histone exchange (GO:0043486)3.03307378
85histone H3 deacetylation (GO:0070932)3.02605551
86mitotic nuclear envelope disassembly (GO:0007077)3.02459186
87tolerance induction (GO:0002507)3.00227855
88heme biosynthetic process (GO:0006783)2.99330485
89regulation of leukocyte degranulation (GO:0043300)2.98560319
90protein localization to kinetochore (GO:0034501)2.95518761
91response to host (GO:0075136)2.94953740
92response to host defenses (GO:0052200)2.94953740
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.94953740
94negative regulation of innate immune response (GO:0045824)2.94341775
95regulation of interferon-beta biosynthetic process (GO:0045357)2.91838808
96regulation of mast cell activation involved in immune response (GO:0033006)2.91618104
97response to muramyl dipeptide (GO:0032495)2.90921441
98positive regulation of granulocyte differentiation (GO:0030854)2.89356544
99regulation of gamma-delta T cell differentiation (GO:0045586)2.87585198
100transcription-coupled nucleotide-excision repair (GO:0006283)2.85200343
101protoporphyrinogen IX biosynthetic process (GO:0006782)2.84619693
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.82741733
103termination of RNA polymerase III transcription (GO:0006386)2.82741733
104deoxyribose phosphate biosynthetic process (GO:0046385)2.82546593
1052-deoxyribonucleotide biosynthetic process (GO:0009265)2.82546593
106kinetochore organization (GO:0051383)2.81373195
107regulation of necroptotic process (GO:0060544)2.80029444
108cardiolipin metabolic process (GO:0032048)2.79524583
109kinetochore assembly (GO:0051382)2.79142802
110negative regulation of interleukin-12 production (GO:0032695)2.78633176
111telomere organization (GO:0032200)2.78069024
112intra-S DNA damage checkpoint (GO:0031573)2.77923092
113granulocyte activation (GO:0036230)2.77887452
114telomere maintenance (GO:0000723)2.77838533
115mitotic sister chromatid segregation (GO:0000070)2.77477360
116regulation of B cell receptor signaling pathway (GO:0050855)2.77129561
117regulation of granulocyte differentiation (GO:0030852)2.77044795
118positive regulation of Cdc42 GTPase activity (GO:0043089)2.76418029
119negative regulation of lymphocyte mediated immunity (GO:0002707)2.76255133
120chromosome condensation (GO:0030261)2.74699012
121fusion of sperm to egg plasma membrane (GO:0007342)2.74529277
122histone H3-K36 demethylation (GO:0070544)2.73874321
123deoxyribonucleotide biosynthetic process (GO:0009263)2.73458738
124pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72982184
125attachment of spindle microtubules to kinetochore (GO:0008608)2.72701463
126porphyrin-containing compound biosynthetic process (GO:0006779)2.72478248
127sperm motility (GO:0030317)2.72218674
128positive thymic T cell selection (GO:0045059)2.71132817
129translational elongation (GO:0006414)2.70884719
130rRNA transcription (GO:0009303)2.70453315
131membrane disassembly (GO:0030397)2.69807688
132nuclear envelope disassembly (GO:0051081)2.69807688
133microtubule depolymerization (GO:0007019)2.68669809
134erythrocyte development (GO:0048821)2.68005349
135base-excision repair (GO:0006284)2.67637295
136negative regulation of necroptotic process (GO:0060546)2.67386754
137spermatid development (GO:0007286)2.66870998
138* DNA replication (GO:0006260)2.66481274
139pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.66056834
140respiratory burst (GO:0045730)2.65385203
141negative regulation of myotube differentiation (GO:0010832)2.64425550
142negative regulation of phagocytosis (GO:0050765)2.64181851
143negative regulation of glial cell proliferation (GO:0060253)2.64017870
144pseudouridine synthesis (GO:0001522)2.63871956
145negative regulation of DNA-templated transcription, elongation (GO:0032785)2.63761014
146protein-DNA complex disassembly (GO:0032986)2.62981730
147nucleosome disassembly (GO:0006337)2.62981730
148erythrocyte maturation (GO:0043249)2.62300256
149replicative senescence (GO:0090399)2.62293245
150mitotic metaphase plate congression (GO:0007080)2.62057098
151histone H2A acetylation (GO:0043968)2.61998065
152spliceosomal snRNP assembly (GO:0000387)2.60981018
153ribonucleoprotein complex biogenesis (GO:0022613)2.60158958
154interferon-gamma secretion (GO:0072643)2.59782339
155barbed-end actin filament capping (GO:0051016)2.59453037
156hemoglobin metabolic process (GO:0020027)2.59409359
157thymic T cell selection (GO:0045061)2.59208476
158DNA packaging (GO:0006323)2.59187172
159gas transport (GO:0015669)2.58990503
160myeloid cell activation involved in immune response (GO:0002275)2.58834724
161regulation of nuclear cell cycle DNA replication (GO:0033262)2.58659464
162regulation of hydrogen peroxide metabolic process (GO:0010310)2.58283390
163negative regulation of cell size (GO:0045792)2.58080502
164DNA-dependent DNA replication (GO:0006261)2.55677537
165pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.55329866
166pentose-phosphate shunt (GO:0006098)2.55024324
167leukocyte degranulation (GO:0043299)2.54851954
168viral transcription (GO:0019083)2.54559791
169virion assembly (GO:0019068)2.54559245
170regulation of cell cycle checkpoint (GO:1901976)2.54032003
171regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53147879
172acrosome assembly (GO:0001675)2.53100130
173pentose metabolic process (GO:0019321)2.52510629
174mRNA cleavage (GO:0006379)2.51790077
1757-methylguanosine mRNA capping (GO:0006370)2.51688438
176negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51161023
177RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.50856356
178SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.50401752
179positive regulation of mast cell activation (GO:0033005)2.49718782
180anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49220630
181positive regulation of histone deacetylation (GO:0031065)2.48952455
182natural killer cell differentiation (GO:0001779)2.48902813
183negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.48686142
184phosphatidylethanolamine biosynthetic process (GO:0006646)2.48666325
185mismatch repair (GO:0006298)2.48377368
186detection of external biotic stimulus (GO:0098581)2.48167496
187termination of RNA polymerase II transcription (GO:0006369)2.47837976
188cell wall macromolecule catabolic process (GO:0016998)2.46893083
189cell wall macromolecule metabolic process (GO:0044036)2.46893083
190sulfur amino acid catabolic process (GO:0000098)2.46840136
191positive regulation of protein deacetylation (GO:0090312)2.46721696
192histone H3-K9 modification (GO:0061647)2.46653392
193G1/S transition of mitotic cell cycle (GO:0000082)2.46554330
194cell cycle G1/S phase transition (GO:0044843)2.46554330
195regulation of cilium movement (GO:0003352)2.46549164
196negative regulation of interleukin-6 production (GO:0032715)2.46119226
197sister chromatid segregation (GO:0000819)2.45883736
198maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45337741
199regulation of type I interferon-mediated signaling pathway (GO:0060338)2.45200870
200regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.44585152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.70768198
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.74269272
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47878697
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.35239775
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27989670
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.21052357
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.08683323
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03212666
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.98746834
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87698652
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86205652
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81077084
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.78578457
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68572005
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.67118701
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.65151758
17LXR_22292898_ChIP-Seq_THP-1_Human2.51197039
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43759207
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39073615
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37382051
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.30907955
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26293054
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.21106625
24KDM2B_26808549_Chip-Seq_DND41_Human2.17487939
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15693995
26* FOXP3_21729870_ChIP-Seq_TREG_Human2.13301900
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12825946
28XRN2_22483619_ChIP-Seq_HELA_Human2.11023591
29MAF_26560356_Chip-Seq_TH2_Human2.09800340
30* P68_20966046_ChIP-Seq_HELA_Human2.09114087
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07966403
32* TCF7_22412390_ChIP-Seq_EML_Mouse2.05955664
33MAF_26560356_Chip-Seq_TH1_Human2.03394121
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01444316
35VDR_23849224_ChIP-Seq_CD4+_Human2.01063945
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95758183
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91514676
38RACK7_27058665_Chip-Seq_MCF-7_Human1.89677850
39* GABP_19822575_ChIP-Seq_HepG2_Human1.88174978
40AR_21909140_ChIP-Seq_LNCAP_Human1.87424713
41VDR_24763502_ChIP-Seq_THP-1_Human1.83606945
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83071199
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82407679
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.79854952
45UTX_26944678_Chip-Seq_JUKART_Human1.79376292
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.78849138
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.77999103
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77669889
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.77620609
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76651124
51BCOR_27268052_Chip-Seq_Bcells_Human1.76540519
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76290095
53DCP1A_22483619_ChIP-Seq_HELA_Human1.76285860
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74815046
55CIITA_25753668_ChIP-Seq_RAJI_Human1.73765361
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.71982567
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71921226
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.71006920
59* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70572087
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.68885182
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65863345
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65471674
63MYC_22102868_ChIP-Seq_BL_Human1.65367119
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65323341
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63839824
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.62604814
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.61637709
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59201190
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57182166
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56706369
71VDR_21846776_ChIP-Seq_THP-1_Human1.53801633
72TTF2_22483619_ChIP-Seq_HELA_Human1.51689466
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50944342
74SMC4_20622854_ChIP-Seq_HELA_Human1.50461576
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48212300
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46851350
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45376240
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42092583
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41852606
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41727746
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37387818
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34537185
83NCOR1_26117541_ChIP-Seq_K562_Human1.34298653
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.34172501
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32920307
86E2F1_20622854_ChIP-Seq_HELA_Human1.32513027
87CTCF_21964334_Chip-Seq_Bcells_Human1.31044488
88CREB1_26743006_Chip-Seq_LNCaP_Human1.30954684
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30871275
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30632465
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.29922080
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29524038
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29164153
94SPI1_23127762_ChIP-Seq_K562_Human1.28665139
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28559563
96SA1_27219007_Chip-Seq_Bcells_Human1.28522384
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28151063
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27438875
99CTCF_26484167_Chip-Seq_Bcells_Mouse1.26839725
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26605403
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.26590899
102KDM5A_27292631_Chip-Seq_BREAST_Human1.25579522
103GATA1_19941826_ChIP-Seq_K562_Human1.24691672
104KDM2B_26808549_Chip-Seq_K562_Human1.23740011
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23731617
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22028471
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21155609
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20634451
109ELK1_19687146_ChIP-ChIP_HELA_Human1.19046906
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18329366
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16797589
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16560321
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16487774
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15514553
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15485256
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14405800
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14239287
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14129817
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13842553
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13812744
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12904778
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12565022
123RARB_24833708_ChIP-Seq_LIVER_Mouse1.11327781
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10843963
125ETS1_21867929_ChIP-Seq_TH2_Mouse1.10349586
126SPI1_23547873_ChIP-Seq_NB4_Human1.10131157
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09311174
128FOXP1_21924763_ChIP-Seq_HESCs_Human1.08194059
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07808201
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07407320
131GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07267252
132MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07076101
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07028796
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06698791
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05965955
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05739349
137PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05174419
138ERG_21242973_ChIP-ChIP_JURKAT_Human1.05111269
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04654219
140* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03181767
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00022422
142KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99080779
143TP63_19390658_ChIP-ChIP_HaCaT_Human0.98128493
144SCL_19346495_ChIP-Seq_HPC-7_Human0.95298278
145PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94127591
146RUNX1_22412390_ChIP-Seq_EML_Mouse0.92979905
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92892982
148MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92164720
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91916883
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89789500
151* YY1_22570637_ChIP-Seq_MALME-3M_Human0.88312265
152CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87423264
153TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86702550
154MYC_18940864_ChIP-ChIP_HL60_Human0.85810223
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85546818
156KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84639625
157TFEB_21752829_ChIP-Seq_HELA_Human0.84138200
158* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82984200
159STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82189831
160ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81499426
161* PHF8_20622854_ChIP-Seq_HELA_Human0.81054196
162* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79330585
163CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78835831
164NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78782147
165* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78686134
166BCL6_27268052_Chip-Seq_Bcells_Human0.78512328
167* TET1_21451524_ChIP-Seq_MESCs_Mouse0.78379853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.62412532
2MP0010094_abnormal_chromosome_stability4.46768606
3MP0003693_abnormal_embryo_hatching4.13145519
4MP0005410_abnormal_fertilization3.62622658
5MP0003111_abnormal_nucleus_morphology3.47745374
6MP0003077_abnormal_cell_cycle3.33614040
7MP0005083_abnormal_biliary_tract3.22077035
8MP0008007_abnormal_cellular_replicative3.12906794
9MP0005451_abnormal_body_composition3.08029020
10MP0009278_abnormal_bone_marrow2.96192313
11MP0005058_abnormal_lysosome_morphology2.91085013
12MP0002396_abnormal_hematopoietic_system2.79626178
13MP0004957_abnormal_blastocyst_morpholog2.77595129
14* MP0008058_abnormal_DNA_repair2.67214846
15MP0008877_abnormal_DNA_methylation2.66453883
16MP0000537_abnormal_urethra_morphology2.61338715
17MP0003303_peritoneal_inflammation2.57008898
18MP0002254_reproductive_system_inflammat2.32856064
19MP0005075_abnormal_melanosome_morpholog2.24169739
20MP0005464_abnormal_platelet_physiology2.21332578
21MP0003724_increased_susceptibility_to2.16726985
22MP0002419_abnormal_innate_immunity2.11754958
23MP0008789_abnormal_olfactory_epithelium2.11098220
24MP0003806_abnormal_nucleotide_metabolis2.07587234
25* MP0001929_abnormal_gametogenesis1.99196927
26MP0001986_abnormal_taste_sensitivity1.96839718
27MP0004858_abnormal_nervous_system1.93877733
28MP0003763_abnormal_thymus_physiology1.90440560
29MP0001790_abnormal_immune_system1.90110928
30MP0005387_immune_system_phenotype1.90110928
31MP0001730_embryonic_growth_arrest1.88923932
32MP0003191_abnormal_cellular_cholesterol1.83717637
33MP0004808_abnormal_hematopoietic_stem1.82951884
34MP0006292_abnormal_olfactory_placode1.80352885
35MP0005408_hypopigmentation1.77272906
36MP0008932_abnormal_embryonic_tissue1.75173072
37MP0009840_abnormal_foam_cell1.73503375
38MP0003186_abnormal_redox_activity1.70684178
39MP0001849_ear_inflammation1.65126580
40MP0002210_abnormal_sex_determination1.61672444
41MP0002160_abnormal_reproductive_system1.61249939
42MP0003786_premature_aging1.59563859
43MP0005394_taste/olfaction_phenotype1.59180529
44MP0005499_abnormal_olfactory_system1.59180529
45MP0000350_abnormal_cell_proliferation1.54639314
46MP0004510_myositis1.53789580
47* MP0003698_abnormal_male_reproductive1.53780715
48MP0000313_abnormal_cell_death1.53616519
49MP0004233_abnormal_muscle_weight1.52599618
50MP0000490_abnormal_crypts_of1.51968659
51MP0005377_hearing/vestibular/ear_phenot1.50393511
52MP0003878_abnormal_ear_physiology1.50393511
53MP0001145_abnormal_male_reproductive1.50015209
54MP0003646_muscle_fatigue1.47155821
55* MP0002398_abnormal_bone_marrow1.44121098
56MP0005076_abnormal_cell_differentiation1.43508857
57MP0006036_abnormal_mitochondrial_physio1.42759721
58MP0002019_abnormal_tumor_incidence1.39739715
59MP0002132_abnormal_respiratory_system1.36180322
60MP0010307_abnormal_tumor_latency1.35357278
61MP0003718_maternal_effect1.34924451
62MP0001764_abnormal_homeostasis1.34427917
63MP0000653_abnormal_sex_gland1.33430375
64MP0001533_abnormal_skeleton_physiology1.32845993
65MP0004147_increased_porphyrin_level1.31333365
66MP0000689_abnormal_spleen_morphology1.28870522
67MP0002653_abnormal_ependyma_morphology1.28820115
68MP0010155_abnormal_intestine_physiology1.26628508
69MP0003866_abnormal_defecation1.22149740
70MP0000703_abnormal_thymus_morphology1.21815240
71MP0002722_abnormal_immune_system1.20686942
72* MP0002429_abnormal_blood_cell1.20601047
73MP0009672_abnormal_birth_weight1.19259902
74MP0004947_skin_inflammation1.15623764
75MP0009333_abnormal_splenocyte_physiolog1.14830025
76MP0005310_abnormal_salivary_gland1.14315774
77* MP0000716_abnormal_immune_system1.13654964
78MP0001672_abnormal_embryogenesis/_devel1.12627815
79MP0005380_embryogenesis_phenotype1.12627815
80MP0005671_abnormal_response_to1.11911409
81MP0003300_gastrointestinal_ulcer1.10188209
82MP0003656_abnormal_erythrocyte_physiolo1.09702959
83MP0001697_abnormal_embryo_size1.09175265
84MP0010386_abnormal_urinary_bladder1.08891692
85MP0003183_abnormal_peptide_metabolism1.08403158
86MP0002420_abnormal_adaptive_immunity1.07639148
87MP0008469_abnormal_protein_level1.07427670
88MP0002080_prenatal_lethality1.07302637
89MP0003984_embryonic_growth_retardation1.06945301
90MP0004264_abnormal_extraembryonic_tissu1.05496760
91MP0004130_abnormal_muscle_cell1.03801980
92MP0001819_abnormal_immune_cell1.02805109
93MP0002088_abnormal_embryonic_growth/wei1.01448596
94MP0001835_abnormal_antigen_presentation0.99489016
95MP0005389_reproductive_system_phenotype0.99108607
96* MP0002161_abnormal_fertility/fecundity0.98233067
97MP0000015_abnormal_ear_pigmentation0.97901243
98MP0001800_abnormal_humoral_immune0.97030321
99MP0000372_irregular_coat_pigmentation0.96437799
100MP0002249_abnormal_larynx_morphology0.95101719
101MP0009764_decreased_sensitivity_to0.94046547
102MP0005666_abnormal_adipose_tissue0.93826450
103MP0001663_abnormal_digestive_system0.92961551
104MP0004185_abnormal_adipocyte_glucose0.90579778
105MP0000358_abnormal_cell_content/0.90150995
106MP0005397_hematopoietic_system_phenotyp0.90022938
107MP0001545_abnormal_hematopoietic_system0.90022938
108MP0003172_abnormal_lysosome_physiology0.89397302
109MP0003453_abnormal_keratinocyte_physiol0.88994490
110MP0003436_decreased_susceptibility_to0.87470672
111MP0000750_abnormal_muscle_regeneration0.86238520
112MP0005266_abnormal_metabolism0.85728963
113MP0002277_abnormal_respiratory_mucosa0.85060184
114* MP0002405_respiratory_system_inflammati0.84227426
115MP0002085_abnormal_embryonic_tissue0.82650816
116MP0000678_abnormal_parathyroid_gland0.82578407
117MP0002723_abnormal_immune_serum0.81625152
118MP0003567_abnormal_fetal_cardiomyocyte0.81327974
119MP0000685_abnormal_immune_system0.80434488
120MP0002933_joint_inflammation0.79987013
121MP0000858_altered_metastatic_potential0.79078275
122MP0001119_abnormal_female_reproductive0.79034389
123MP0006035_abnormal_mitochondrial_morpho0.78523444
124MP0005375_adipose_tissue_phenotype0.78505172
125MP0002452_abnormal_antigen_presenting0.78209545
126MP0008874_decreased_physiological_sensi0.78180493
127MP0000609_abnormal_liver_physiology0.76422126
128MP0003705_abnormal_hypodermis_morpholog0.75867555
129MP0003879_abnormal_hair_cell0.74817449
130MP0000465_gastrointestinal_hemorrhage0.73067219
131MP0002998_abnormal_bone_remodeling0.72712502
132MP0002735_abnormal_chemical_nociception0.72205621
133MP0006082_CNS_inflammation0.71947310
134MP0005319_abnormal_enzyme/_coenzyme0.71577145
135MP0005025_abnormal_response_to0.70417269
136MP0005220_abnormal_exocrine_pancreas0.69718569
137MP0001873_stomach_inflammation0.69239424
138MP0003221_abnormal_cardiomyocyte_apopto0.67259984
139MP0002148_abnormal_hypersensitivity_rea0.67133671
140MP0008260_abnormal_autophagy0.66840624
141MP0003828_pulmonary_edema0.66082424
142MP0009785_altered_susceptibility_to0.65997953
143MP0001293_anophthalmia0.64604226
144MP0000343_altered_response_to0.64120770
145MP0001348_abnormal_lacrimal_gland0.63956859
146MP0005381_digestive/alimentary_phenotyp0.63520999
147MP0000470_abnormal_stomach_morphology0.63065306
148MP0003075_altered_response_to0.61285504
149MP0005621_abnormal_cell_physiology0.61228651
150MP0002086_abnormal_extraembryonic_tissu0.61141219
151MP0005174_abnormal_tail_pigmentation0.60424305
152MP0000598_abnormal_liver_morphology0.58845641
153MP0005000_abnormal_immune_tolerance0.58260828
154MP0001845_abnormal_inflammatory_respons0.58146642
155MP0003943_abnormal_hepatobiliary_system0.58118555

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.23232640
2Aplastic anemia (HP:0001915)5.36192853
311 pairs of ribs (HP:0000878)4.98223790
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.98103076
5Hypochromic anemia (HP:0001931)4.73295372
6Eczematoid dermatitis (HP:0000976)4.43995972
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.93164601
8Increased cerebral lipofuscin (HP:0011813)3.91173238
9Recurrent abscess formation (HP:0002722)3.85489490
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.66766413
11Thrombocytosis (HP:0001894)3.63305060
12Recurrent bacterial skin infections (HP:0005406)3.56961038
13Myositis (HP:0100614)3.56297817
14Abnormal number of erythroid precursors (HP:0012131)3.54432871
15Abnormality of cells of the erythroid lineage (HP:0012130)3.42164319
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.36790794
17Pancytopenia (HP:0001876)3.34327234
18Cutaneous melanoma (HP:0012056)3.29582482
19Abnormality of the anterior horn cell (HP:0006802)3.27070720
20Degeneration of anterior horn cells (HP:0002398)3.27070720
21Stomatitis (HP:0010280)3.25723595
22Recurrent bronchitis (HP:0002837)3.22509160
23Prolonged bleeding time (HP:0003010)3.21959146
24Abnormality of macrophages (HP:0004311)3.20475339
25Microcytic anemia (HP:0001935)3.18982263
26Myopathic facies (HP:0002058)3.16458453
27Orchitis (HP:0100796)3.14059324
28Aplasia/Hypoplasia of the uvula (HP:0010293)3.12745823
29Abnormality of the preputium (HP:0100587)3.11877736
30Abnormality of chromosome stability (HP:0003220)3.11348088
31Selective tooth agenesis (HP:0001592)3.10520423
32Chronic obstructive pulmonary disease (HP:0006510)3.03960404
33Obstructive lung disease (HP:0006536)3.03960404
34Oral leukoplakia (HP:0002745)3.02088754
35Gastrointestinal infarctions (HP:0005244)2.98582341
36Impulsivity (HP:0100710)2.98081705
37Bronchitis (HP:0012387)2.97009884
38Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.96859764
39Recurrent fungal infections (HP:0002841)2.89000430
40Cellulitis (HP:0100658)2.86976808
41Reticulocytopenia (HP:0001896)2.84950225
42Reticulocytosis (HP:0001923)2.84402083
43Gastrointestinal inflammation (HP:0004386)2.83662152
44Bone marrow hypocellularity (HP:0005528)2.82968148
45Colon cancer (HP:0003003)2.82835550
46Meckel diverticulum (HP:0002245)2.80513602
47Cholelithiasis (HP:0001081)2.79449610
48Abnormality of the ileum (HP:0001549)2.76698549
49Patellar aplasia (HP:0006443)2.75070788
50Aplasia/Hypoplasia of the patella (HP:0006498)2.74278232
51Nasal polyposis (HP:0100582)2.73617569
52Type I transferrin isoform profile (HP:0003642)2.72855625
53IgM deficiency (HP:0002850)2.63558090
54Inflammation of the large intestine (HP:0002037)2.62333102
55Abnormality of the fingertips (HP:0001211)2.61665015
56Ragged-red muscle fibers (HP:0003200)2.60809714
57Absent/shortened dynein arms (HP:0200106)2.60181610
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.60181610
59Sloping forehead (HP:0000340)2.59444940
60Chronic bronchitis (HP:0004469)2.58760971
61Increased IgE level (HP:0003212)2.58594611
62Myelodysplasia (HP:0002863)2.57702258
63Abnormal protein glycosylation (HP:0012346)2.54854350
64Abnormal glycosylation (HP:0012345)2.54854350
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54854350
66Abnormal protein N-linked glycosylation (HP:0012347)2.54854350
67Large eyes (HP:0001090)2.53433873
68Metaphyseal cupping (HP:0003021)2.52785832
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.51943716
70Progressive muscle weakness (HP:0003323)2.51122161
71Birth length less than 3rd percentile (HP:0003561)2.50009055
72Easy fatigability (HP:0003388)2.49400514
73Abnormal hemoglobin (HP:0011902)2.49139254
74Abnormality of the thoracic spine (HP:0100711)2.49030750
75Colitis (HP:0002583)2.48634727
76Urticaria (HP:0001025)2.48155496
77Gingivitis (HP:0000230)2.45873006
78Abnormal respiratory epithelium morphology (HP:0012253)2.45826340
79Abnormal respiratory motile cilium morphology (HP:0005938)2.45826340
80Panhypogammaglobulinemia (HP:0003139)2.45532513
81Recurrent skin infections (HP:0001581)2.43580671
82Hypertensive crisis (HP:0100735)2.42224152
83Tongue fasciculations (HP:0001308)2.37934383
84Clumsiness (HP:0002312)2.37410133
85Increased serum ferritin (HP:0003281)2.37320801
86Mediastinal lymphadenopathy (HP:0100721)2.36238717
87Rhinitis (HP:0012384)2.36164939
88Type 2 muscle fiber atrophy (HP:0003554)2.35759411
89Reduced antithrombin III activity (HP:0001976)2.34565609
90Slow saccadic eye movements (HP:0000514)2.34290155
91Encephalitis (HP:0002383)2.33992025
92Abnormal gallbladder morphology (HP:0012437)2.33688028
93Chromsome breakage (HP:0040012)2.32173433
94Cerebral hypomyelination (HP:0006808)2.32039790
95Purpura (HP:0000979)2.30952678
96Meningitis (HP:0001287)2.30630099
97Small intestinal stenosis (HP:0012848)2.29443880
98Duodenal stenosis (HP:0100867)2.29443880
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28489770
100Loss of speech (HP:0002371)2.27354559
101Rough bone trabeculation (HP:0100670)2.25224173
102Poikiloderma (HP:0001029)2.24984450
103Progressive external ophthalmoplegia (HP:0000590)2.24674483
104Abnormal gallbladder physiology (HP:0012438)2.24098011
105Cholecystitis (HP:0001082)2.24098011
106Diaphragmatic weakness (HP:0009113)2.23806958
107Abnormality of the gallbladder (HP:0005264)2.23560331
108Retrobulbar optic neuritis (HP:0100654)2.23069852
109Optic neuritis (HP:0100653)2.23069852
110Pustule (HP:0200039)2.22816700
111Limb hypertonia (HP:0002509)2.22621327
112Abnormal spermatogenesis (HP:0008669)2.21481014
113Missing ribs (HP:0000921)2.21136020
114Muscle fiber atrophy (HP:0100295)2.20030911
115Recurrent gram-negative bacterial infections (HP:0005420)2.19648314
116Abnormality of the carotid arteries (HP:0005344)2.19190123
117Epistaxis (HP:0000421)2.18776680
118Premature graying of hair (HP:0002216)2.18717652
119Dysostosis multiplex (HP:0000943)2.18435871
120Recurrent cutaneous fungal infections (HP:0011370)2.18130721
121Chronic mucocutaneous candidiasis (HP:0002728)2.18130721
122Gastrointestinal stroma tumor (HP:0100723)2.17522548
123Spontaneous hematomas (HP:0007420)2.16758900
124Increased serum lactate (HP:0002151)2.16103687
125Abnormality of iron homeostasis (HP:0011031)2.15977269
126B lymphocytopenia (HP:0010976)2.15645508
127Abnormality of B cell number (HP:0010975)2.15645508
128Breast hypoplasia (HP:0003187)2.15067300
129Thoracic kyphosis (HP:0002942)2.14979833
130Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14071384
131Abnormality of polysaccharide metabolism (HP:0011012)2.14071384
132Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14071384
133Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11215937
134Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11215937
135Abnormality of the nasal mucosa (HP:0000433)2.10367741
136Abnormal respiratory motile cilium physiology (HP:0012261)2.10336756
137Recurrent sinusitis (HP:0011108)2.09950543
138Abnormality of the columella (HP:0009929)2.05028457
139Rectal prolapse (HP:0002035)2.04949788
140Rhabdomyolysis (HP:0003201)2.03830508
141Lymphoma (HP:0002665)2.03038547
142Exercise-induced myalgia (HP:0003738)2.02806920
143Abnormality of reticulocytes (HP:0004312)2.02719500
144Absent thumb (HP:0009777)2.00664526
145Acute hepatic failure (HP:0006554)2.00631814
146Microvesicular hepatic steatosis (HP:0001414)2.00525346
147Muscle fibrillation (HP:0010546)2.00200407
148Chest pain (HP:0100749)1.98865878
149Increased IgM level (HP:0003496)1.98050423
150Clubbing of toes (HP:0100760)1.97487716
151Abnormal delayed hypersensitivity skin test (HP:0002963)1.97300742
152Episodic fever (HP:0001954)1.96359384
153Bulbar palsy (HP:0001283)1.94685388
154Poor head control (HP:0002421)1.94490191
155Abnormality of the intervertebral disk (HP:0005108)1.91277900
156Bronchiectasis (HP:0002110)1.91270062
157Vacuolated lymphocytes (HP:0001922)1.90309947
158Hepatic necrosis (HP:0002605)1.89435872
159Hyperglycinuria (HP:0003108)1.88739094
160Elevated erythrocyte sedimentation rate (HP:0003565)1.87930837
161Carpal bone hypoplasia (HP:0001498)1.87754880
162Increased serum pyruvate (HP:0003542)1.87552974
163Abnormality of glycolysis (HP:0004366)1.87552974
164Fatigue (HP:0012378)1.85179334
165Neutropenia (HP:0001875)1.84754584
166Lymphopenia (HP:0001888)1.83944744
167Hepatocellular necrosis (HP:0001404)1.83536546
168Abnormality of T cell physiology (HP:0011840)1.82991309
169Leukopenia (HP:0001882)1.82595225
170Tracheoesophageal fistula (HP:0002575)1.81948040
171Centrally nucleated skeletal muscle fibers (HP:0003687)1.81401551
172Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80910426
173Petechiae (HP:0000967)1.80761192
174Vasculitis (HP:0002633)1.79761167
175Broad distal phalanx of finger (HP:0009836)1.79650195
176Atelectasis (HP:0100750)1.79343470
177Microretrognathia (HP:0000308)1.78985188
178Pelvic girdle muscle weakness (HP:0003749)1.78740322
179Abnormality of the duodenum (HP:0002246)1.77841422
180Pulmonary fibrosis (HP:0002206)1.77349293
181Nephroblastoma (Wilms tumor) (HP:0002667)1.75512550
182Abnormality of transition element cation homeostasis (HP:0011030)1.75280797
183Neoplasm of the pancreas (HP:0002894)1.75106338
184Granulocytopenia (HP:0001913)1.74291052
185Severe visual impairment (HP:0001141)1.73891210
186Keratitis (HP:0000491)1.73451127
187Hemorrhage of the eye (HP:0011885)1.73092433
188Hepatosplenomegaly (HP:0001433)1.72725214
189Abnormality of pyrimidine metabolism (HP:0004353)1.72583385
190Increased CSF lactate (HP:0002490)1.72210763
191Toxemia of pregnancy (HP:0100603)1.71192933
192Anorexia (HP:0002039)1.71011963
193Poikilocytosis (HP:0004447)1.70918842
194Abnormal lung lobation (HP:0002101)1.67796162
195Abnormality of DNA repair (HP:0003254)1.67224537
196Overlapping toe (HP:0001845)1.67059425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.38119504
2TRIB33.49084102
3WEE13.41785452
4NEK22.56634626
5TAOK12.50396865
6TNK22.50390490
7BRSK12.43912812
8PNCK2.43659637
9CDC72.36425967
10SMG12.34868637
11BRSK22.28542499
12SRPK12.19157471
13BCKDK2.18356945
14PASK2.17433980
15TESK12.16019645
16MAP4K12.07603718
17SIK12.06330333
18RIPK42.06203627
19EEF2K2.02099838
20EIF2AK12.00636397
21MARK21.96172303
22CDK191.95437776
23VRK11.91357392
24NEK11.90183395
25MAP3K71.87122862
26PDK31.85601695
27PDK41.85601695
28NME21.85324646
29PRKD21.76197818
30TTK1.73962656
31STK161.73922550
32ICK1.72238441
33TESK21.64148627
34ATR1.61857226
35EPHB11.57378175
36TSSK61.55886504
37EIF2AK21.53163918
38MAP3K31.48140148
39FLT31.47160515
40FES1.46940158
41MAP2K21.42065640
42BMX1.39117390
43BLK1.36335147
44PLK11.35927765
45SIK21.35854377
46TAOK31.35313665
47PLK41.34139019
48MAP3K131.33899222
49CCNB11.32780875
50TYK21.31594813
51CDK81.29352582
52PIM21.28481859
53AURKA1.28278109
54CSF1R1.28245451
55PRKD31.26580599
56TEC1.25294844
57BTK1.24537088
58RPS6KB21.16754672
59MAP2K31.15693457
60PTK61.14465275
61ERN11.13304709
62DYRK31.13243630
63TLK11.12572884
64ZAK1.12117498
65TAOK21.11998117
66MAP3K11.10917319
67PLK31.10783839
68TGFBR11.10696566
69MAP3K141.10625411
70MAP2K71.09547843
71CHEK21.09291624
72IRAK41.09247021
73CDK71.05580444
74HCK1.02261845
75CAMK1D1.01936353
76AURKB1.01924760
77IKBKB1.01018261
78KIT1.00365331
79MARK31.00219349
80MKNK10.98448743
81PRPF4B0.96386875
82ERBB30.94165330
83FGR0.93665293
84CSK0.93615028
85ZAP700.93559168
86STK100.91646371
87KDR0.91085120
88HIPK20.90666719
89CHEK10.88813700
90EIF2AK30.88534632
91PIM10.88253175
92PDPK10.85697505
93MAPK120.83261966
94MAP3K80.82523469
95CLK10.80675823
96STK40.78026074
97TBK10.77012483
98BRAF0.73570505
99JAK30.73555599
100IKBKE0.73025944
101CDK120.72735148
102TRPM70.72180159
103DYRK1B0.72118553
104CDK40.71076260
105MAP3K110.70833460
106YES10.69494897
107STK380.67847571
108MAP3K100.67461710
109MATK0.67142383
110ACVR1B0.65437548
111PDK10.64990009
112RPS6KA40.64248425
113CAMK40.64115344
114TXK0.63792851
115PKN20.63724760
116SCYL20.63353976
117CDC42BPA0.61343785
118PDK20.61138986
119LYN0.60563358
120MAP2K60.60264459
121MAPKAPK30.59560451
122RPS6KL10.59124179
123RPS6KC10.59124179
124KSR20.58319735
125MAPKAPK50.58169474
126STK110.57892504
127RPS6KA60.57386022
128PTK2B0.57024505
129LRRK20.56926331
130SGK30.54661705
131MTOR0.53775756
132PAK40.52482617
133TTN0.52150167
134GRK60.51851786
135MAP3K40.51722301
136MAPKAPK20.50612846
137SIK30.50335265
138CSNK2A10.50043910
139ATM0.49226661
140RPS6KA10.49186525
141FGFR40.48759241
142MAPK70.48481173
143* CDK20.48432439
144RAF10.48422266
145PRKAA20.48055459
146RPS6KA20.45963232
147NME10.44477017
148PAK10.44320125
149CAMK1G0.44011058
150VRK20.43671002
151IRAK30.43228541
152SYK0.42859448
153CSNK2A20.42171521
154DYRK20.40612466
155CAMKK10.40490579
156CAMK10.39592560
157RPS6KA50.39472040
158LCK0.39383586
159MAPK110.38857513
160BMPR20.37146976
161RPS6KB10.35938570
162IRAK20.35161113

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.32054682
2Mismatch repair_Homo sapiens_hsa034303.87316194
3* Base excision repair_Homo sapiens_hsa034103.33960271
4Homologous recombination_Homo sapiens_hsa034402.86021964
5RNA polymerase_Homo sapiens_hsa030202.85847467
6One carbon pool by folate_Homo sapiens_hsa006702.83623643
7Spliceosome_Homo sapiens_hsa030402.74317241
8Proteasome_Homo sapiens_hsa030502.66611899
9Ribosome_Homo sapiens_hsa030102.63932682
10Pyrimidine metabolism_Homo sapiens_hsa002402.61290582
11Nucleotide excision repair_Homo sapiens_hsa034202.61114686
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59547261
13RNA transport_Homo sapiens_hsa030132.37787412
14Osteoclast differentiation_Homo sapiens_hsa043802.36483842
15Fanconi anemia pathway_Homo sapiens_hsa034602.25995171
16Cell cycle_Homo sapiens_hsa041102.22199818
17B cell receptor signaling pathway_Homo sapiens_hsa046622.14002573
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.97680984
19Basal transcription factors_Homo sapiens_hsa030221.82491194
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82025782
21Pentose phosphate pathway_Homo sapiens_hsa000301.78208400
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74335645
23Selenocompound metabolism_Homo sapiens_hsa004501.71512508
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69467692
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67812469
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66524405
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.62947426
28Leishmaniasis_Homo sapiens_hsa051401.57972526
29RNA degradation_Homo sapiens_hsa030181.53287051
30Non-small cell lung cancer_Homo sapiens_hsa052231.51951953
31Chronic myeloid leukemia_Homo sapiens_hsa052201.50308555
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.49382652
33Lysosome_Homo sapiens_hsa041421.47426942
34Protein export_Homo sapiens_hsa030601.46406227
35Purine metabolism_Homo sapiens_hsa002301.43092433
36mRNA surveillance pathway_Homo sapiens_hsa030151.40861303
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39909591
38Vitamin B6 metabolism_Homo sapiens_hsa007501.38402703
39Tuberculosis_Homo sapiens_hsa051521.38301589
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.37662088
41Hepatitis C_Homo sapiens_hsa051601.36743538
42VEGF signaling pathway_Homo sapiens_hsa043701.34885239
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.34313844
44p53 signaling pathway_Homo sapiens_hsa041151.28834246
45mTOR signaling pathway_Homo sapiens_hsa041501.28334188
46Pancreatic cancer_Homo sapiens_hsa052121.27261182
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25520240
48Malaria_Homo sapiens_hsa051441.22115106
49TNF signaling pathway_Homo sapiens_hsa046681.19949890
50Folate biosynthesis_Homo sapiens_hsa007901.19052678
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18328258
52Biosynthesis of amino acids_Homo sapiens_hsa012301.14073933
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12558858
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11550474
55T cell receptor signaling pathway_Homo sapiens_hsa046601.10844598
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10707505
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.10393044
58Carbon metabolism_Homo sapiens_hsa012001.08782493
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07998849
60Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07583050
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.07038639
62Fructose and mannose metabolism_Homo sapiens_hsa000511.06759445
63Insulin resistance_Homo sapiens_hsa049311.04400473
64Chemokine signaling pathway_Homo sapiens_hsa040621.01352437
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01240365
66Endocytosis_Homo sapiens_hsa041441.00743956
67* Non-homologous end-joining_Homo sapiens_hsa034500.99808933
68Lysine degradation_Homo sapiens_hsa003100.99363521
69Epstein-Barr virus infection_Homo sapiens_hsa051690.98935973
70AMPK signaling pathway_Homo sapiens_hsa041520.97877951
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97875378
72Galactose metabolism_Homo sapiens_hsa000520.96053111
73Inositol phosphate metabolism_Homo sapiens_hsa005620.95114418
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.93603766
75N-Glycan biosynthesis_Homo sapiens_hsa005100.92121542
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92091316
77Toxoplasmosis_Homo sapiens_hsa051450.91653761
78Choline metabolism in cancer_Homo sapiens_hsa052310.91613209
79Insulin signaling pathway_Homo sapiens_hsa049100.91044016
80Platelet activation_Homo sapiens_hsa046110.90580520
81Endometrial cancer_Homo sapiens_hsa052130.90388177
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.88527249
83Herpes simplex infection_Homo sapiens_hsa051680.88057139
84Staphylococcus aureus infection_Homo sapiens_hsa051500.87714631
85Bladder cancer_Homo sapiens_hsa052190.83585084
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83339511
87Sulfur relay system_Homo sapiens_hsa041220.81798842
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81331945
89Pyruvate metabolism_Homo sapiens_hsa006200.80330788
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.80142541
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.78320170
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78264429
93Propanoate metabolism_Homo sapiens_hsa006400.76764534
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72285314
95Systemic lupus erythematosus_Homo sapiens_hsa053220.71890120
96Glutathione metabolism_Homo sapiens_hsa004800.71500027
97Primary immunodeficiency_Homo sapiens_hsa053400.70998113
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70584516
99Linoleic acid metabolism_Homo sapiens_hsa005910.70179435
100African trypanosomiasis_Homo sapiens_hsa051430.69824767
101FoxO signaling pathway_Homo sapiens_hsa040680.69285696
102Huntingtons disease_Homo sapiens_hsa050160.69079316
103Legionellosis_Homo sapiens_hsa051340.66778198
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.65916409
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65606436
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65199232
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64827126
108Hematopoietic cell lineage_Homo sapiens_hsa046400.63219015
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.60818688
110Allograft rejection_Homo sapiens_hsa053300.60068619
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59582331
112Colorectal cancer_Homo sapiens_hsa052100.57734868
113Arachidonic acid metabolism_Homo sapiens_hsa005900.56873190
114Metabolic pathways_Homo sapiens_hsa011000.56481934
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56052386
116Viral carcinogenesis_Homo sapiens_hsa052030.56017523
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54769712
118ABC transporters_Homo sapiens_hsa020100.52105501
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52018073
120Parkinsons disease_Homo sapiens_hsa050120.50583546
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49977964
122Antigen processing and presentation_Homo sapiens_hsa046120.48998776
123Prolactin signaling pathway_Homo sapiens_hsa049170.48949172
124MAPK signaling pathway_Homo sapiens_hsa040100.48811265
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48406314
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48249461
127Measles_Homo sapiens_hsa051620.48043501
128Shigellosis_Homo sapiens_hsa051310.46966589
129HTLV-I infection_Homo sapiens_hsa051660.46895493
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45462561
131Notch signaling pathway_Homo sapiens_hsa043300.42596700
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42043228
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41082620
134Graft-versus-host disease_Homo sapiens_hsa053320.39236643
135Glycerolipid metabolism_Homo sapiens_hsa005610.38461273
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.38205726
137GnRH signaling pathway_Homo sapiens_hsa049120.38196695
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37580203
139Prostate cancer_Homo sapiens_hsa052150.36903970
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.36863634
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35980392
142Arginine and proline metabolism_Homo sapiens_hsa003300.35210930
143Oocyte meiosis_Homo sapiens_hsa041140.33594808
144Fatty acid degradation_Homo sapiens_hsa000710.33218106
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.33079375
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32973627
147Influenza A_Homo sapiens_hsa051640.32526861
148beta-Alanine metabolism_Homo sapiens_hsa004100.32320719
149Peroxisome_Homo sapiens_hsa041460.31293192
150Oxidative phosphorylation_Homo sapiens_hsa001900.30935431
151Phenylalanine metabolism_Homo sapiens_hsa003600.30769805
152Fat digestion and absorption_Homo sapiens_hsa049750.29346775
153Other glycan degradation_Homo sapiens_hsa005110.28876677
154RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28511141
155Apoptosis_Homo sapiens_hsa042100.27878507
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.25783931
157Hepatitis B_Homo sapiens_hsa051610.25710594
158Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25388289
159Histidine metabolism_Homo sapiens_hsa003400.24448406
160Acute myeloid leukemia_Homo sapiens_hsa052210.21825849
161Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20344024
162Thyroid cancer_Homo sapiens_hsa052160.19106535
163Tryptophan metabolism_Homo sapiens_hsa003800.19013917
164Chemical carcinogenesis_Homo sapiens_hsa052040.18660130
165Regulation of autophagy_Homo sapiens_hsa041400.18602058
166Sulfur metabolism_Homo sapiens_hsa009200.18474097
167Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17838234
168Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17255166

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