POLM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.17988114
2regulation of gamma-delta T cell differentiation (GO:0045586)5.04810005
3regulation of gamma-delta T cell activation (GO:0046643)4.84005780
4B cell receptor signaling pathway (GO:0050853)4.61289123
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.47104051
6positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.39809642
7positive regulation of B cell differentiation (GO:0045579)3.92327708
8regulation of interferon-beta biosynthetic process (GO:0045357)3.84383699
9cellular extravasation (GO:0045123)3.83005711
10regulation of superoxide anion generation (GO:0032928)3.81026285
11cellular response to interleukin-15 (GO:0071350)3.77814846
12modulation by symbiont of host immune response (GO:0052553)3.71337801
13positive regulation by symbiont of host defense response (GO:0052509)3.71337801
14modulation by symbiont of host defense response (GO:0052031)3.71337801
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.71337801
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.71337801
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.71337801
18negative regulation of histone methylation (GO:0031061)3.69965496
19detection of bacterium (GO:0016045)3.58322059
20defense response to protozoan (GO:0042832)3.54611265
21response to muramyl dipeptide (GO:0032495)3.53960684
22immunoglobulin mediated immune response (GO:0016064)3.50813583
23detection of other organism (GO:0098543)3.45440115
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.43981061
25regulation of histone H3-K27 methylation (GO:0061085)3.42621443
26positive thymic T cell selection (GO:0045059)3.40636917
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38930018
28CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.37825692
29regulation of interleukin-12 biosynthetic process (GO:0045075)3.37515006
30germinal center formation (GO:0002467)3.35864039
31negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33804289
32regulation of B cell differentiation (GO:0045577)3.32236595
33T cell selection (GO:0045058)3.29352605
34B cell homeostasis (GO:0001782)3.24785674
35antigen processing and presentation of endogenous antigen (GO:0019883)3.24319614
36hepatocyte apoptotic process (GO:0097284)3.22572511
37response to protozoan (GO:0001562)3.21160873
38protein localization to kinetochore (GO:0034501)3.15908350
39regulation of histone H3-K9 methylation (GO:0051570)3.14387248
40response to type I interferon (GO:0034340)3.13691824
41regulation of mast cell degranulation (GO:0043304)3.13450052
42negative regulation of interleukin-8 production (GO:0032717)3.12860749
43serine transport (GO:0032329)3.12652706
44negative regulation of T cell mediated immunity (GO:0002710)3.12369984
45regulation of antigen processing and presentation (GO:0002577)3.11407088
46negative regulation of innate immune response (GO:0045824)3.11404161
47protein localization to chromosome, centromeric region (GO:0071459)3.10638654
48negative regulation of leukocyte mediated immunity (GO:0002704)3.08779917
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08509461
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08509461
51type I interferon signaling pathway (GO:0060337)3.07804227
52cellular response to type I interferon (GO:0071357)3.07804227
53T cell migration (GO:0072678)3.06505485
54mannose metabolic process (GO:0006013)3.04924518
55regulation of T cell mediated cytotoxicity (GO:0001914)3.03752547
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03578553
57negative regulation of T-helper cell differentiation (GO:0045623)3.03578553
58negative regulation of cAMP-mediated signaling (GO:0043951)3.02955677
59regulation of RNA export from nucleus (GO:0046831)3.01908287
60L-serine transport (GO:0015825)3.01583427
61neutrophil mediated immunity (GO:0002446)3.01473296
62positive regulation of Cdc42 GTPase activity (GO:0043089)3.01403752
63positive regulation of defense response to virus by host (GO:0002230)3.01078177
64positive regulation of T cell mediated cytotoxicity (GO:0001916)3.00806800
65regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99938649
66respiratory burst (GO:0045730)2.97417018
67positive regulation of antigen processing and presentation (GO:0002579)2.96634658
68positive regulation of isotype switching (GO:0045830)2.95695095
69regulation of mast cell activation involved in immune response (GO:0033006)2.95137385
70regulation of granulocyte differentiation (GO:0030852)2.93759491
71activated T cell proliferation (GO:0050798)2.92914916
72thymic T cell selection (GO:0045061)2.92252361
73negative thymic T cell selection (GO:0045060)2.91138273
74negative T cell selection (GO:0043383)2.90659737
75positive regulation of cell adhesion mediated by integrin (GO:0033630)2.90162053
76regulation of defense response to virus by host (GO:0050691)2.89983606
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88165656
78negative regulation of interleukin-6 production (GO:0032715)2.87596108
79interferon-gamma secretion (GO:0072643)2.86210895
80regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.83053409
81V(D)J recombination (GO:0033151)2.82945705
82response to peptidoglycan (GO:0032494)2.81667017
83regulation of mast cell activation (GO:0033003)2.79507188
84negative regulation of alpha-beta T cell activation (GO:0046636)2.79496743
85NIK/NF-kappaB signaling (GO:0038061)2.77673840
86neutrophil activation involved in immune response (GO:0002283)2.77551372
87positive T cell selection (GO:0043368)2.76564422
88antigen processing and presentation via MHC class Ib (GO:0002475)2.75829950
89detection of external biotic stimulus (GO:0098581)2.75098981
90negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.73115012
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72662940
92positive regulation of interferon-alpha production (GO:0032727)2.72579841
93negative regulation of erythrocyte differentiation (GO:0045647)2.72446272
94neutrophil activation (GO:0042119)2.70814452
95negative regulation of interleukin-12 production (GO:0032695)2.70733215
96regulation of germinal center formation (GO:0002634)2.69743456
97T-helper cell differentiation (GO:0042093)2.69285735
98protein localization to chromosome (GO:0034502)2.68897435
99regulation of B cell receptor signaling pathway (GO:0050855)2.68687828
100regulation of alpha-beta T cell proliferation (GO:0046640)2.67886907
101positive regulation of gene expression, epigenetic (GO:0045815)2.67179534
102macrophage activation involved in immune response (GO:0002281)2.64627899
103mitotic chromosome condensation (GO:0007076)2.63909789
104antigen receptor-mediated signaling pathway (GO:0050851)2.60974018
105mitotic nuclear envelope disassembly (GO:0007077)2.58850557
106positive regulation of immunoglobulin production (GO:0002639)2.58285408
107regulation of sister chromatid cohesion (GO:0007063)2.56298532
108tolerance induction (GO:0002507)2.55137357
109natural killer cell differentiation (GO:0001779)2.54151924
110regulation of telomere maintenance via telomerase (GO:0032210)2.52697713
111leukocyte aggregation (GO:0070486)2.51724469
112response to laminar fluid shear stress (GO:0034616)2.50109778
113heterochromatin organization (GO:0070828)2.47760104
114nuclear pore complex assembly (GO:0051292)2.46339146
115T cell homeostasis (GO:0043029)2.45662797
116negative regulation of phagocytosis (GO:0050765)2.45439060
117positive regulation of mitotic sister chromatid separation (GO:1901970)2.45108609
118positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.45108609
119positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.45108609
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44694741
121positive regulation of chromosome segregation (GO:0051984)2.43525316
122positive regulation of alpha-beta T cell proliferation (GO:0046641)2.43394313
123negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.43187055
124negative regulation of cell killing (GO:0031342)2.43187055
125positive regulation of histone deacetylation (GO:0031065)2.42852179
126regulation of translation in response to stress (GO:0043555)2.41705343
127nuclear envelope disassembly (GO:0051081)2.41190537
128membrane disassembly (GO:0030397)2.41190537
129positive regulation of B cell activation (GO:0050871)2.39743783
130lymph vessel development (GO:0001945)2.39538469
1313-UTR-mediated mRNA stabilization (GO:0070935)2.38925125
132maturation of 5.8S rRNA (GO:0000460)2.33807193
133mitotic sister chromatid segregation (GO:0000070)2.33414896
134positive regulation of DNA recombination (GO:0045911)2.31651772
135mitotic metaphase plate congression (GO:0007080)2.31039129
136regulation of nucleobase-containing compound transport (GO:0032239)2.30796588
137regulation of Cdc42 GTPase activity (GO:0043088)2.30426906
138negative regulation of toll-like receptor signaling pathway (GO:0034122)2.30340062
139negative regulation of gene silencing (GO:0060969)2.30262191
140regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.30077184
141negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.29814961
142DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.28464799
143chromatin assembly (GO:0031497)2.28051516
144regulation of response to interferon-gamma (GO:0060330)2.26404385
145response to interleukin-15 (GO:0070672)2.26145584
146interferon-gamma production (GO:0032609)2.26005713
147regulation of spindle organization (GO:0090224)2.24995183
148positive regulation of granulocyte differentiation (GO:0030854)2.24978048
149histone H3-K4 methylation (GO:0051568)2.24703508
150regulation of B cell proliferation (GO:0030888)2.24051202
151positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.23935151
152negative regulation of bone resorption (GO:0045779)2.23659298
153positive regulation of bone remodeling (GO:0046852)2.23052101
154positive regulation of bone resorption (GO:0045780)2.23052101
155regulation of superoxide metabolic process (GO:0090322)2.22825109
156JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.22292163
157histone H3-K9 demethylation (GO:0033169)2.21755976
158positive regulation of protein deacetylation (GO:0090312)2.20999136
159lymphocyte homeostasis (GO:0002260)2.20044269
160sister chromatid segregation (GO:0000819)2.19394061
161regulation of histone methylation (GO:0031060)2.18267758
162positive regulation by host of viral transcription (GO:0043923)2.17917242
163histone H2A monoubiquitination (GO:0035518)2.16711595
164negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.16276894
165regulation of mitotic spindle organization (GO:0060236)2.15970472
166T cell costimulation (GO:0031295)2.15700564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.37449786
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.20439828
3MYC_22102868_ChIP-Seq_BL_Human3.83866532
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.30691793
5VDR_21846776_ChIP-Seq_THP-1_Human2.74165051
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68803137
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.63629639
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60200148
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48021528
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.45905070
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.40757995
12SCL_19346495_ChIP-Seq_HPC-7_Human2.40620410
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29324197
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29063485
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27937613
16* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12146174
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00565279
18MAF_26560356_Chip-Seq_TH1_Human1.99384465
19* UTX_26944678_Chip-Seq_JUKART_Human1.97698492
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94064246
21MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93585477
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.90826628
23LXR_22292898_ChIP-Seq_THP-1_Human1.90761103
24* BCL6_27268052_Chip-Seq_Bcells_Human1.90399813
25TCF7_22412390_ChIP-Seq_EML_Mouse1.90280523
26MYB_26560356_Chip-Seq_TH2_Human1.86844352
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86101065
28* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80089901
29MYB_26560356_Chip-Seq_TH1_Human1.79600080
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79452153
31* BCOR_27268052_Chip-Seq_Bcells_Human1.75220847
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75018646
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74987187
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74119240
35* P68_20966046_ChIP-Seq_HELA_Human1.72505683
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.69890824
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.69789259
38CIITA_25753668_ChIP-Seq_RAJI_Human1.64429906
39* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64202778
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63202365
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61614311
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59556810
43RUNX_20019798_ChIP-Seq_JUKART_Human1.57834301
44VDR_24763502_ChIP-Seq_THP-1_Human1.57694557
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.53999086
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51478043
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48388174
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48272666
49SPI1_23547873_ChIP-Seq_NB4_Human1.46167972
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.44885846
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42979443
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42840666
53KDM2B_26808549_Chip-Seq_DND41_Human1.41781380
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41377012
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41365792
56* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40656261
57* E2F1_20622854_ChIP-Seq_HELA_Human1.37238111
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37194439
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37080620
60* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37069241
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36569546
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.35530531
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34469946
64MAF_26560356_Chip-Seq_TH2_Human1.34084280
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.32812120
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32767222
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.32657606
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30987390
69NCOR1_26117541_ChIP-Seq_K562_Human1.29799844
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29690104
71* P300_27268052_Chip-Seq_Bcells_Human1.28026253
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27205509
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.26289656
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25809370
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.25770365
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25760053
77SMC4_20622854_ChIP-Seq_HELA_Human1.24957024
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24269982
79* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24096971
80* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24011963
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23888196
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23641051
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23342643
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22290843
85* PHF8_20622854_ChIP-Seq_HELA_Human1.21214301
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20482291
87TFEB_21752829_ChIP-Seq_HELA_Human1.20214634
88* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19105798
89MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19023013
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.17615118
91GATA3_26560356_Chip-Seq_TH2_Human1.17530929
92KDM5A_27292631_Chip-Seq_BREAST_Human1.16683077
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.16244928
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15861430
95* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15337022
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13403052
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.12464153
98* XRN2_22483619_ChIP-Seq_HELA_Human1.12311221
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11957369
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10715282
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10551834
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.10202386
103GATA1_22025678_ChIP-Seq_K562_Human1.09430426
104RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08549505
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08417253
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06722539
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05657620
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05578672
109CTCF_21964334_Chip-Seq_Bcells_Human1.05299047
110* RARB_24833708_ChIP-Seq_LIVER_Mouse1.05136409
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05119133
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05076327
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04096077
114VDR_23849224_ChIP-Seq_CD4+_Human1.03675019
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03579162
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01746587
117ATF3_27146783_Chip-Seq_COLON_Human1.01624681
118SPI1_20517297_ChIP-Seq_HL60_Human1.01040457
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00716821
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00223427
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.99720985
122CLOCK_20551151_ChIP-Seq_293T_Human0.99412555
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98623971
124* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98524026
125SA1_27219007_Chip-Seq_Bcells_Human0.98434500
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98351942
127GATA3_27048872_Chip-Seq_THYMUS_Human0.98024942
128* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97955495
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97450823
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96943194
131SPI1_23127762_ChIP-Seq_K562_Human0.95874887
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95563732
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95102217
134HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95020044
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94990104
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94150322
137GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93976359
138RACK7_27058665_Chip-Seq_MCF-7_Human0.93333512
139CHD1_26751641_Chip-Seq_LNCaP_Human0.93231852
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90850470
141GATA6_25053715_ChIP-Seq_YYC3_Human0.90815441
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90763296
143AR_21909140_ChIP-Seq_LNCAP_Human0.90548987
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88092396
145KDM2B_26808549_Chip-Seq_JURKAT_Human0.87596394
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87507396
147FOXP3_21729870_ChIP-Seq_TREG_Human0.87432269
148GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86314647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to2.93608509
2MP0003172_abnormal_lysosome_physiology2.75116093
3MP0001800_abnormal_humoral_immune2.68765345
4MP0004381_abnormal_hair_follicle2.64079623
5MP0003693_abnormal_embryo_hatching2.48303290
6MP0005387_immune_system_phenotype2.38261654
7MP0001790_abnormal_immune_system2.38261654
8MP0003763_abnormal_thymus_physiology2.38114017
9MP0003705_abnormal_hypodermis_morpholog2.37426304
10MP0001835_abnormal_antigen_presentation2.35040005
11MP0000685_abnormal_immune_system2.32795748
12MP0010352_gastrointestinal_tract_polyps2.25838906
13MP0003303_peritoneal_inflammation2.19897406
14MP0009333_abnormal_splenocyte_physiolog2.16867204
15MP0002396_abnormal_hematopoietic_system2.16847315
16* MP0002452_abnormal_antigen_presenting2.08069285
17MP0003111_abnormal_nucleus_morphology2.04381043
18MP0002148_abnormal_hypersensitivity_rea2.01527445
19* MP0002398_abnormal_bone_marrow2.01518121
20MP0005075_abnormal_melanosome_morpholog2.00208289
21MP0004957_abnormal_blastocyst_morpholog1.98426222
22MP0003077_abnormal_cell_cycle1.98366130
23MP0002138_abnormal_hepatobiliary_system1.92590263
24MP0010094_abnormal_chromosome_stability1.91800890
25MP0005076_abnormal_cell_differentiation1.90751411
26MP0000689_abnormal_spleen_morphology1.86200531
27MP0003566_abnormal_cell_adhesion1.86150073
28MP0005671_abnormal_response_to1.85334820
29MP0003300_gastrointestinal_ulcer1.82780492
30MP0006054_spinal_hemorrhage1.81935179
31* MP0002420_abnormal_adaptive_immunity1.79504522
32MP0005000_abnormal_immune_tolerance1.79320725
33MP0002723_abnormal_immune_serum1.75340132
34* MP0001819_abnormal_immune_cell1.75238880
35* MP0002722_abnormal_immune_system1.74771891
36MP0008057_abnormal_DNA_replication1.74457843
37MP0005023_abnormal_wound_healing1.74296976
38MP0001986_abnormal_taste_sensitivity1.71995940
39* MP0000716_abnormal_immune_system1.70659656
40MP0000490_abnormal_crypts_of1.69381592
41MP0000703_abnormal_thymus_morphology1.68603676
42MP0003436_decreased_susceptibility_to1.67789829
43MP0004808_abnormal_hematopoietic_stem1.60714165
44MP0002877_abnormal_melanocyte_morpholog1.60005362
45MP0000015_abnormal_ear_pigmentation1.59406352
46MP0003183_abnormal_peptide_metabolism1.59073594
47MP0000350_abnormal_cell_proliferation1.58314264
48MP0004947_skin_inflammation1.58137513
49MP0004510_myositis1.56628072
50MP0004264_abnormal_extraembryonic_tissu1.56453678
51MP0001849_ear_inflammation1.56012456
52MP0008007_abnormal_cellular_replicative1.52899028
53MP0002405_respiratory_system_inflammati1.50906046
54MP0010155_abnormal_intestine_physiology1.49604176
55MP0005451_abnormal_body_composition1.49279351
56MP0001873_stomach_inflammation1.49217555
57* MP0002429_abnormal_blood_cell1.49155623
58MP0003191_abnormal_cellular_cholesterol1.46845763
59MP0002166_altered_tumor_susceptibility1.46382492
60MP0006082_CNS_inflammation1.42797903
61MP0002132_abnormal_respiratory_system1.41419654
62MP0001730_embryonic_growth_arrest1.35787185
63MP0005058_abnormal_lysosome_morphology1.35037400
64MP0009278_abnormal_bone_marrow1.32299828
65MP0002019_abnormal_tumor_incidence1.27534798
66MP0002006_tumorigenesis1.25890382
67MP0003279_aneurysm1.25110323
68MP0008469_abnormal_protein_level1.23319536
69MP0003453_abnormal_keratinocyte_physiol1.23196144
70MP0001348_abnormal_lacrimal_gland1.21280409
71MP0000465_gastrointestinal_hemorrhage1.20537187
72MP0005025_abnormal_response_to1.19196108
73MP0008260_abnormal_autophagy1.18199011
74MP0009764_decreased_sensitivity_to1.17298274
75MP0000733_abnormal_muscle_development1.13614166
76MP0001845_abnormal_inflammatory_respons1.11887750
77MP0005174_abnormal_tail_pigmentation1.11563775
78MP0009785_altered_susceptibility_to1.09906526
79MP0002086_abnormal_extraembryonic_tissu1.07459764
80MP0003091_abnormal_cell_migration1.06542643
81MP0003866_abnormal_defecation1.05987039
82MP0001672_abnormal_embryogenesis/_devel1.04289774
83MP0005380_embryogenesis_phenotype1.04289774
84MP0001697_abnormal_embryo_size1.04254725
85MP0000858_altered_metastatic_potential1.03151358
86MP0002088_abnormal_embryonic_growth/wei1.02318354
87MP0003984_embryonic_growth_retardation1.01861613
88MP0002419_abnormal_innate_immunity1.00541482
89MP0002933_joint_inflammation0.99018758
90MP0002254_reproductive_system_inflammat0.97613689
91MP0000372_irregular_coat_pigmentation0.96911206
92MP0003045_fibrosis0.95957688
93MP0004197_abnormal_fetal_growth/weight/0.95835887
94MP0005310_abnormal_salivary_gland0.93659679
95MP0005621_abnormal_cell_physiology0.92345896
96MP0005397_hematopoietic_system_phenotyp0.91553736
97MP0001545_abnormal_hematopoietic_system0.91553736
98MP0001851_eye_inflammation0.91320826
99MP0004130_abnormal_muscle_cell0.90820032
100MP0009931_abnormal_skin_appearance0.89784775
101MP0002085_abnormal_embryonic_tissue0.87625461
102MP0002080_prenatal_lethality0.86587630
103MP0009840_abnormal_foam_cell0.86157214
104MP0001879_abnormal_lymphatic_vessel0.86118025
105MP0001663_abnormal_digestive_system0.85479507
106MP0002928_abnormal_bile_duct0.85283913
107MP0000477_abnormal_intestine_morphology0.84534029
108MP0000313_abnormal_cell_death0.83929256
109MP0002060_abnormal_skin_morphology0.83681604
110MP0002084_abnormal_developmental_patter0.83544441
111MP0010307_abnormal_tumor_latency0.82967204
112MP0001915_intracranial_hemorrhage0.82458486
113MP0001853_heart_inflammation0.82451546
114MP0001216_abnormal_epidermal_layer0.82007076
115MP0010368_abnormal_lymphatic_system0.79780404
116MP0003448_altered_tumor_morphology0.79424641
117MP0005464_abnormal_platelet_physiology0.78092750
118MP0002925_abnormal_cardiovascular_devel0.77423727
119MP0003828_pulmonary_edema0.75641995
120MP0002009_preneoplasia0.75182439
121MP0000371_diluted_coat_color0.74107795
122MP0005501_abnormal_skin_physiology0.73935343
123MP0005083_abnormal_biliary_tract0.72231729
124MP0001533_abnormal_skeleton_physiology0.71062762
125MP0010030_abnormal_orbit_morphology0.70906923
126MP0004185_abnormal_adipocyte_glucose0.69857355
127MP0002998_abnormal_bone_remodeling0.69042281
128MP0002970_abnormal_white_adipose0.68724983
129MP0009115_abnormal_fat_cell0.68535438
130MP0005257_abnormal_intraocular_pressure0.66231617
131MP0000249_abnormal_blood_vessel0.65870238
132MP0002653_abnormal_ependyma_morphology0.65839629
133MP0003646_muscle_fatigue0.62671426
134MP0002693_abnormal_pancreas_physiology0.62048299
135MP0005360_urolithiasis0.61849990
136MP0001764_abnormal_homeostasis0.61001923
137MP0002136_abnormal_kidney_physiology0.60499573
138MP0008961_abnormal_basal_metabolism0.58858630
139MP0005390_skeleton_phenotype0.57932564
140MP0000609_abnormal_liver_physiology0.54922601
141MP0002277_abnormal_respiratory_mucosa0.54720807
142MP0008874_decreased_physiological_sensi0.54422328
143MP0001958_emphysema0.52642580
144MP0004883_abnormal_blood_vessel0.51163176
145MP0002163_abnormal_gland_morphology0.50427195
146MP0005670_abnormal_white_adipose0.49773967
147MP0000569_abnormal_digit_pigmentation0.49560566

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.54591662
2Myositis (HP:0100614)4.36592598
3Cellulitis (HP:0100658)4.28436662
4Elevated erythrocyte sedimentation rate (HP:0003565)4.05436479
5Recurrent viral infections (HP:0004429)4.04300801
6Papilloma (HP:0012740)3.88262588
7Verrucae (HP:0200043)3.88262588
8Abnormality of B cell number (HP:0010975)3.82300382
9B lymphocytopenia (HP:0010976)3.82300382
10Orchitis (HP:0100796)3.76775063
11Recurrent bronchitis (HP:0002837)3.72194868
12Optic neuritis (HP:0100653)3.64795790
13Retrobulbar optic neuritis (HP:0100654)3.64795790
14Stomatitis (HP:0010280)3.62172954
15Ulnar bowing (HP:0003031)3.51067311
16Gastrointestinal infarctions (HP:0005244)3.31490892
17Obstructive lung disease (HP:0006536)3.25498393
18Chronic obstructive pulmonary disease (HP:0006510)3.25498393
19Panhypogammaglobulinemia (HP:0003139)3.22935460
20T lymphocytopenia (HP:0005403)3.19335168
21Encephalitis (HP:0002383)3.16222909
22Recurrent skin infections (HP:0001581)3.15349286
23Chest pain (HP:0100749)3.11190660
24Abnormality of T cell number (HP:0011839)3.06075245
25Abnormality of the intervertebral disk (HP:0005108)3.03535673
26Colitis (HP:0002583)3.03455413
27Pulmonary infiltrates (HP:0002113)2.99825832
28Recurrent fungal infections (HP:0002841)2.96346989
29Abnormality of macrophages (HP:0004311)2.89271526
30Recurrent gram-negative bacterial infections (HP:0005420)2.82950568
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.82631502
32Vertebral arch anomaly (HP:0008438)2.81202998
33Hemoptysis (HP:0002105)2.77556827
34Meningitis (HP:0001287)2.75856318
35Small epiphyses (HP:0010585)2.74112767
36Combined immunodeficiency (HP:0005387)2.72728761
37Emphysema (HP:0002097)2.71669588
38Pustule (HP:0200039)2.68327679
39Hypochromic anemia (HP:0001931)2.67869217
40Inflammation of the large intestine (HP:0002037)2.67778645
41Keratoconjunctivitis (HP:0001096)2.67720466
42Gastrointestinal inflammation (HP:0004386)2.61013939
43Abnormality of the fingertips (HP:0001211)2.59922730
44Congenital stationary night blindness (HP:0007642)2.57156541
45Aortic aneurysm (HP:0004942)2.56191068
46Recurrent sinusitis (HP:0011108)2.56181280
47J-shaped sella turcica (HP:0002680)2.55672095
48Keratoconjunctivitis sicca (HP:0001097)2.54903488
49Osteomyelitis (HP:0002754)2.54329149
50Sparse lateral eyebrow (HP:0005338)2.53236260
51Autoimmune thrombocytopenia (HP:0001973)2.50620053
52IgM deficiency (HP:0002850)2.48014618
53Increased IgM level (HP:0003496)2.47142458
54Gastrointestinal stroma tumor (HP:0100723)2.46454806
55Prolonged bleeding time (HP:0003010)2.46218113
56Epistaxis (HP:0000421)2.45508359
57Hemorrhage of the eye (HP:0011885)2.39994220
58Gingivitis (HP:0000230)2.37245499
59Abnormality of the pleura (HP:0002103)2.34307533
60Abnormality of T cells (HP:0002843)2.34102759
61Lymphopenia (HP:0001888)2.33967248
62Chronic otitis media (HP:0000389)2.32391044
63IgG deficiency (HP:0004315)2.29569749
64Long eyelashes (HP:0000527)2.28986722
65Dysostosis multiplex (HP:0000943)2.28561849
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28525144
67Recurrent otitis media (HP:0000403)2.27889080
68Bowed forearm bones (HP:0003956)2.26320804
69Bowing of the arm (HP:0006488)2.26320804
70Protrusio acetabuli (HP:0003179)2.25307916
71Chronic sinusitis (HP:0011109)2.24694812
72Thyroiditis (HP:0100646)2.23786041
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.23736935
74Abnormality of the prostate (HP:0008775)2.23451857
75Severe combined immunodeficiency (HP:0004430)2.23325776
76Autoimmune hemolytic anemia (HP:0001890)2.22658121
77Arterial thrombosis (HP:0004420)2.20415115
78Hypergammaglobulinemia (HP:0010702)2.20005164
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19777966
80Abnormality of polysaccharide metabolism (HP:0011012)2.19777966
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19777966
82Keratitis (HP:0000491)2.15957740
83Bronchitis (HP:0012387)2.15260901
84Cerebral aneurysm (HP:0004944)2.10938598
85Urticaria (HP:0001025)2.10675660
86Episodic fever (HP:0001954)2.10518917
87Eosinophilia (HP:0001880)2.10187456
88Eczematoid dermatitis (HP:0000976)2.06763306
89Periodontitis (HP:0000704)2.06590849
90Mucopolysacchariduria (HP:0008155)2.04115118
91Urinary glycosaminoglycan excretion (HP:0003541)2.04115118
92Sepsis (HP:0100806)2.03236169
93Aortic dissection (HP:0002647)2.02310639
94Pulmonary embolism (HP:0002204)2.01974998
95Anorexia (HP:0002039)2.00825803
96Viral hepatitis (HP:0006562)1.98332036
97Skin rash (HP:0000988)1.97903316
98Aortic regurgitation (HP:0001659)1.96043059
99Petechiae (HP:0000967)1.95706398
100Lymphoma (HP:0002665)1.95500093
101Nasal polyposis (HP:0100582)1.95285373
102IgA deficiency (HP:0002720)1.93553377
103Chronic mucocutaneous candidiasis (HP:0002728)1.92783282
104Recurrent cutaneous fungal infections (HP:0011370)1.92783282
105Spontaneous hematomas (HP:0007420)1.91586694
106Mitral stenosis (HP:0001718)1.91390037
107Neurodegeneration (HP:0002180)1.90461394
108Flattened epiphyses (HP:0003071)1.89284411
109Restrictive lung disease (HP:0002091)1.88988732
110Ocular albinism (HP:0001107)1.88888725
111Dilatation of the ascending aorta (HP:0005111)1.88213005
112Recurrent abscess formation (HP:0002722)1.87332181
113Skin ulcer (HP:0200042)1.86749008
114Obstructive sleep apnea (HP:0002870)1.86089575
115Recurrent lower respiratory tract infections (HP:0002783)1.86081565
116Patellar aplasia (HP:0006443)1.85735211
117Chronic diarrhea (HP:0002028)1.84886327
118Aplasia/Hypoplasia of the patella (HP:0006498)1.84763932
119Severe visual impairment (HP:0001141)1.83882287
120Broad face (HP:0000283)1.83701990
121Increased neuronal autofluorescent lipopigment (HP:0002074)1.83197133
122Basal cell carcinoma (HP:0002671)1.82697777
123Limited elbow extension (HP:0001377)1.82600953
124Vasculitis (HP:0002633)1.80405204
125Recurrent bacterial skin infections (HP:0005406)1.80119929
126Recurrent pneumonia (HP:0006532)1.79483410
127Back pain (HP:0003418)1.78213331
128Leukocytosis (HP:0001974)1.74800602
129Increased IgE level (HP:0003212)1.73354972
130Long palpebral fissure (HP:0000637)1.73097790
131Rib fusion (HP:0000902)1.72850611
132Facial hemangioma (HP:0000329)1.71577702
133Cervical subluxation (HP:0003308)1.70891454
134Abnormality of T cell physiology (HP:0011840)1.70526757
135Anal stenosis (HP:0002025)1.70362051
136Mitral valve prolapse (HP:0001634)1.69737709
137Mediastinal lymphadenopathy (HP:0100721)1.69597982
138Mesomelia (HP:0003027)1.69141712
139Leukopenia (HP:0001882)1.67573760
140Multiple enchondromatosis (HP:0005701)1.65945511
141Granulocytopenia (HP:0001913)1.65864197
142Deviation of the thumb (HP:0009603)1.63842866
143Thin bony cortex (HP:0002753)1.61225783
144Thrombocytosis (HP:0001894)1.60322649
145Increased density of long bones (HP:0006392)1.60223920
146Blepharitis (HP:0000498)1.59813622
147Abnormality of eosinophils (HP:0001879)1.58866335
148Lip pit (HP:0100267)1.58212665
149Abnormality of the anterior horn cell (HP:0006802)1.58036328
150Degeneration of anterior horn cells (HP:0002398)1.58036328
151Spondylolisthesis (HP:0003302)1.57932799
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.56616604
153Osteolytic defects of the hand bones (HP:0009699)1.56616604
154Spinal cord lesions (HP:0100561)1.56480829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.58809867
2CDK124.24045016
3ERN13.69200154
4MAP4K13.63220878
5STK103.22210138
6TRIB32.91054031
7RIPK42.82872745
8GRK62.74962647
9TNK22.44264553
10FES2.24833591
11EEF2K2.07581325
12NEK21.82628525
13TYK21.60685554
14PKN21.58532525
15ZAP701.55472684
16JAK31.52465776
17KIT1.47629812
18SIK31.43531962
19IRAK31.40843273
20MAP3K71.40297738
21CDK41.32403978
22MELK1.31265850
23LRRK21.26082635
24MAP3K111.25658705
25PRPF4B1.24385313
26ITK1.22854478
27PIM11.19906418
28MAP3K131.19793849
29MOS1.16720097
30CSF1R1.15819832
31MAPK111.15057482
32FGFR41.13535853
33BRD41.12481524
34NLK1.12373768
35CDK91.12313569
36FRK1.12291803
37JAK11.12132282
38BTK1.10068888
39MARK21.10055305
40MARK31.08420081
41SYK1.07096745
42BLK1.05699759
43CDC42BPA1.05354920
44CDK61.04411856
45SMG11.04232962
46MAP2K21.03999371
47MAP2K61.03557986
48TXK1.01950362
49STK31.01642583
50MST41.00471137
51TAOK11.00021364
52MATK0.99028377
53IRAK10.98093487
54MAP3K80.97871688
55RPS6KA40.97412602
56STK38L0.96417496
57STK40.95460319
58CSK0.94428047
59HCK0.92228071
60TGFBR20.90851209
61TESK20.90732359
62MAPK120.89374403
63TTN0.88828488
64MAP2K30.87163261
65RPS6KB20.86445017
66LATS20.85830703
67TBK10.81034285
68CHEK20.80377078
69LCK0.78639559
70STK240.78185430
71SIK10.76264832
72FGFR30.76047267
73TTK0.75797387
74PDK10.72770016
75PRKD20.72135486
76HIPK20.71986839
77TEC0.71412638
78LATS10.71268792
79CDK70.70843920
80TRPM70.70800609
81RPS6KC10.69787711
82RPS6KL10.69787711
83CDC70.69633944
84RPS6KA60.68472617
85LYN0.67776411
86PTK60.66683617
87IKBKB0.66354555
88EPHA30.66246899
89MAPK150.64753408
90KDR0.64601966
91MTOR0.63637310
92CHUK0.63526724
93TAOK30.60851654
94AURKB0.60271416
95CLK10.59532032
96MAP3K60.59478666
97CHEK10.58691137
98SIK20.58174255
99PRKCQ0.58020103
100FGFR20.57722955
101ALK0.57596390
102ICK0.57255095
103MAP3K10.57128479
104PDPK10.55214167
105EPHA20.54834492
106IRAK20.54644109
107PAK20.53620370
108TYRO30.53049763
109PTK2B0.52647302
110PDGFRA0.52241759
111CAMKK10.51110186
112PINK10.50500010
113PDGFRB0.50266781
114IKBKE0.49608038
115MAPKAPK20.48536905
116MAP3K140.46321468
117RPS6KA20.46150435
118BCKDK0.46145650
119STK380.45106940
120DYRK1B0.45060012
121JAK20.44996945
122BMPR20.44964809
123IRAK40.44732386
124BUB10.44333067
125MAPK30.43627932
126PIK3CG0.42505978
127PLK40.40315101
128TLK10.39564185
129STK110.38463616
130PLK10.38212025
131PRKD10.37980744
132ABL10.37830799
133CAMK40.37811383
134BMX0.37559696
135MAPK70.37429464
136* CDK20.37272461
137EPHB10.36629038
138MAP3K30.35149794
139INSR0.35063500
140ZAK0.34994429
141EGFR0.34344727
142FYN0.34143809
143PRKAA20.33715770
144MAPK40.33273088
145CAMKK20.33096772

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.66679775
2Allograft rejection_Homo sapiens_hsa053303.08714712
3B cell receptor signaling pathway_Homo sapiens_hsa046623.01057018
4Autoimmune thyroid disease_Homo sapiens_hsa053202.94093895
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.28104387
6Asthma_Homo sapiens_hsa053102.24074832
7Staphylococcus aureus infection_Homo sapiens_hsa051502.17371532
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.08703015
9Type I diabetes mellitus_Homo sapiens_hsa049402.05944506
10Leishmaniasis_Homo sapiens_hsa051401.74192686
11Cell cycle_Homo sapiens_hsa041101.71457084
12p53 signaling pathway_Homo sapiens_hsa041151.70521044
13Chronic myeloid leukemia_Homo sapiens_hsa052201.69910302
14Antigen processing and presentation_Homo sapiens_hsa046121.66397988
15Small cell lung cancer_Homo sapiens_hsa052221.63534894
16Base excision repair_Homo sapiens_hsa034101.61468537
17Herpes simplex infection_Homo sapiens_hsa051681.61164752
18Pancreatic cancer_Homo sapiens_hsa052121.59053789
19Hematopoietic cell lineage_Homo sapiens_hsa046401.57474724
20Osteoclast differentiation_Homo sapiens_hsa043801.57435544
21RNA transport_Homo sapiens_hsa030131.56942182
22T cell receptor signaling pathway_Homo sapiens_hsa046601.55405699
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52935147
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47105747
25Measles_Homo sapiens_hsa051621.46063348
26Epstein-Barr virus infection_Homo sapiens_hsa051691.45761905
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45482507
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36975000
29MicroRNAs in cancer_Homo sapiens_hsa052061.33346292
30Spliceosome_Homo sapiens_hsa030401.33079362
31Non-small cell lung cancer_Homo sapiens_hsa052231.30573987
32Viral carcinogenesis_Homo sapiens_hsa052031.30556026
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.29970950
34HTLV-I infection_Homo sapiens_hsa051661.29746500
35Toxoplasmosis_Homo sapiens_hsa051451.26458383
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20822433
37Apoptosis_Homo sapiens_hsa042101.16734936
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16365061
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.14845377
40DNA replication_Homo sapiens_hsa030301.14779804
41Hepatitis B_Homo sapiens_hsa051611.13600027
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.13007742
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10045147
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09842075
45mRNA surveillance pathway_Homo sapiens_hsa030151.09665474
46Acute myeloid leukemia_Homo sapiens_hsa052211.06096131
47Notch signaling pathway_Homo sapiens_hsa043301.05093413
48RNA degradation_Homo sapiens_hsa030181.04097971
49Shigellosis_Homo sapiens_hsa051311.01195468
50Mismatch repair_Homo sapiens_hsa034301.01024641
51Influenza A_Homo sapiens_hsa051641.00675155
52Bladder cancer_Homo sapiens_hsa052190.98860966
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97355010
54* Non-homologous end-joining_Homo sapiens_hsa034500.95894908
55FoxO signaling pathway_Homo sapiens_hsa040680.92347452
56Basal transcription factors_Homo sapiens_hsa030220.91937832
57Tuberculosis_Homo sapiens_hsa051520.91348938
58TNF signaling pathway_Homo sapiens_hsa046680.89556285
59Adherens junction_Homo sapiens_hsa045200.89210141
60Viral myocarditis_Homo sapiens_hsa054160.89200268
61Prostate cancer_Homo sapiens_hsa052150.88406779
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.88320652
63Rheumatoid arthritis_Homo sapiens_hsa053230.87403157
64Colorectal cancer_Homo sapiens_hsa052100.86445102
65Proteoglycans in cancer_Homo sapiens_hsa052050.85735796
66Platelet activation_Homo sapiens_hsa046110.84747924
67Homologous recombination_Homo sapiens_hsa034400.84025045
68Malaria_Homo sapiens_hsa051440.83949127
69Lysine degradation_Homo sapiens_hsa003100.83814597
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83696725
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82463747
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82433949
73mTOR signaling pathway_Homo sapiens_hsa041500.81887367
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81418370
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79607999
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79009239
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78537955
78Systemic lupus erythematosus_Homo sapiens_hsa053220.77111989
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.76467803
80Sulfur relay system_Homo sapiens_hsa041220.75927519
81Chemokine signaling pathway_Homo sapiens_hsa040620.74431495
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73030023
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71319011
84Fanconi anemia pathway_Homo sapiens_hsa034600.70616109
85Insulin resistance_Homo sapiens_hsa049310.70028882
86Regulation of autophagy_Homo sapiens_hsa041400.69304069
87Choline metabolism in cancer_Homo sapiens_hsa052310.69169684
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69127859
89Inositol phosphate metabolism_Homo sapiens_hsa005620.68738039
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67757198
91TGF-beta signaling pathway_Homo sapiens_hsa043500.67096830
92Legionellosis_Homo sapiens_hsa051340.66461684
93Other glycan degradation_Homo sapiens_hsa005110.66278976
94ABC transporters_Homo sapiens_hsa020100.66012419
95VEGF signaling pathway_Homo sapiens_hsa043700.65595855
96Hepatitis C_Homo sapiens_hsa051600.65352186
97One carbon pool by folate_Homo sapiens_hsa006700.65297234
98Prolactin signaling pathway_Homo sapiens_hsa049170.64600858
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62886742
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62657637
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62307612
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61965399
103Thyroid cancer_Homo sapiens_hsa052160.61935525
104RNA polymerase_Homo sapiens_hsa030200.61875262
105African trypanosomiasis_Homo sapiens_hsa051430.61644868
106Graft-versus-host disease_Homo sapiens_hsa053320.60659918
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59725541
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.59183038
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58700634
110Lysosome_Homo sapiens_hsa041420.58472840
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58460603
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58314470
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.58189117
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57209602
115Endometrial cancer_Homo sapiens_hsa052130.57043761
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56500632
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.55700005
118Pathways in cancer_Homo sapiens_hsa052000.54920679
119HIF-1 signaling pathway_Homo sapiens_hsa040660.54128233
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54104798
121Focal adhesion_Homo sapiens_hsa045100.53566923
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53047722
123Dorso-ventral axis formation_Homo sapiens_hsa043200.49558768
124Renal cell carcinoma_Homo sapiens_hsa052110.48739643
125Hippo signaling pathway_Homo sapiens_hsa043900.48386265
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48323160
127Linoleic acid metabolism_Homo sapiens_hsa005910.48160958
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47381889
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47234620
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.47218010
131Glioma_Homo sapiens_hsa052140.46873512
132Phagosome_Homo sapiens_hsa041450.42580787
133Pertussis_Homo sapiens_hsa051330.42100806
134Arachidonic acid metabolism_Homo sapiens_hsa005900.40203748
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39859274
136Glycerolipid metabolism_Homo sapiens_hsa005610.38586015
137Ether lipid metabolism_Homo sapiens_hsa005650.37181710
138MAPK signaling pathway_Homo sapiens_hsa040100.35898453
139Endocytosis_Homo sapiens_hsa041440.32966381
140Sphingolipid metabolism_Homo sapiens_hsa006000.30665214
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27282911

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