POLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA polymerase type-A family member. The encoded protein plays a role in DNA repair and homologous recombination. This gene shares its 5' exons with some transcripts from overlapping GeneID: 79441, which encodes an augmentin-like protein complex subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.22122593
2multicellular organism reproduction (GO:0032504)5.94800100
3axonemal dynein complex assembly (GO:0070286)5.88729490
4sperm motility (GO:0030317)5.86797967
5piRNA metabolic process (GO:0034587)5.82734377
6motile cilium assembly (GO:0044458)5.80780078
7acrosome assembly (GO:0001675)5.57094193
8sperm-egg recognition (GO:0035036)5.57016882
9behavioral response to nicotine (GO:0035095)5.37091828
10fusion of sperm to egg plasma membrane (GO:0007342)5.35865600
11meiotic chromosome segregation (GO:0045132)5.19501956
12cell-cell recognition (GO:0009988)5.08253345
13acrosome reaction (GO:0007340)5.06095031
14male meiosis (GO:0007140)5.04538984
15response to pheromone (GO:0019236)5.01455081
16binding of sperm to zona pellucida (GO:0007339)4.99750373
17epithelial cilium movement (GO:0003351)4.83049324
18reproduction (GO:0000003)4.57795830
19cilium movement (GO:0003341)4.44444819
20DNA deamination (GO:0045006)4.15494632
21cell wall macromolecule metabolic process (GO:0044036)4.15411624
22cell wall macromolecule catabolic process (GO:0016998)4.15411624
23microtubule depolymerization (GO:0007019)4.13462071
24spermatid development (GO:0007286)4.13452264
25fucose catabolic process (GO:0019317)4.09059846
26L-fucose metabolic process (GO:0042354)4.09059846
27L-fucose catabolic process (GO:0042355)4.09059846
28DNA methylation involved in gamete generation (GO:0043046)4.08617471
29sperm capacitation (GO:0048240)4.05545877
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84741619
31synapsis (GO:0007129)3.79409220
32single fertilization (GO:0007338)3.78930697
33chromosome organization involved in meiosis (GO:0070192)3.75199969
34regulation of cilium movement (GO:0003352)3.73627488
35plasma membrane fusion (GO:0045026)3.73533709
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.69263290
37indolalkylamine catabolic process (GO:0046218)3.65402884
38tryptophan catabolic process (GO:0006569)3.65402884
39indole-containing compound catabolic process (GO:0042436)3.65402884
40synaptonemal complex organization (GO:0070193)3.63725489
41kynurenine metabolic process (GO:0070189)3.59829958
42meiotic cell cycle (GO:0051321)3.59287525
43water-soluble vitamin biosynthetic process (GO:0042364)3.57238375
44synaptonemal complex assembly (GO:0007130)3.55623222
45regulation of activation of Janus kinase activity (GO:0010533)3.54134602
46indolalkylamine metabolic process (GO:0006586)3.47759911
47G-protein coupled receptor internalization (GO:0002031)3.42814377
48regulation of sequestering of triglyceride (GO:0010889)3.40719150
49detection of light stimulus involved in visual perception (GO:0050908)3.34926733
50detection of light stimulus involved in sensory perception (GO:0050962)3.34926733
51cellular ketone body metabolic process (GO:0046950)3.34480657
52protein polyglutamylation (GO:0018095)3.34143860
53axoneme assembly (GO:0035082)3.32064730
54tryptophan metabolic process (GO:0006568)3.25410724
55male meiosis I (GO:0007141)3.16852586
56intra-S DNA damage checkpoint (GO:0031573)3.15685243
57negative regulation of mast cell activation (GO:0033004)3.13294502
58respiratory chain complex IV assembly (GO:0008535)3.13035975
59cilium morphogenesis (GO:0060271)3.10805599
60cornea development in camera-type eye (GO:0061303)3.10543260
61meiotic nuclear division (GO:0007126)3.10172087
62purine ribonucleotide transport (GO:0015868)3.10006262
63platelet dense granule organization (GO:0060155)3.09646447
64spermatogenesis (GO:0007283)3.07188033
65male gamete generation (GO:0048232)3.06675086
66ketone body metabolic process (GO:1902224)3.04665423
67negative regulation of phagocytosis (GO:0050765)3.04054389
68protein-cofactor linkage (GO:0018065)3.02826693
69positive regulation of cellular amide metabolic process (GO:0034250)3.01708300
70adenine nucleotide transport (GO:0051503)3.01568994
71regulation of nuclear cell cycle DNA replication (GO:0033262)2.99271286
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99221785
73protein complex biogenesis (GO:0070271)2.99205224
74photoreceptor cell maintenance (GO:0045494)2.98278449
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96516713
76mitochondrial respiratory chain complex I assembly (GO:0032981)2.96516713
77NADH dehydrogenase complex assembly (GO:0010257)2.96516713
78superoxide anion generation (GO:0042554)2.96428757
79regulation of DNA endoreduplication (GO:0032875)2.96251009
80regulation of hypersensitivity (GO:0002883)2.95746341
81fertilization (GO:0009566)2.95100073
82DNA packaging (GO:0006323)2.94993276
83nuclear pore complex assembly (GO:0051292)2.94116683
84negative regulation of telomere maintenance (GO:0032205)2.93831919
85mannosylation (GO:0097502)2.91944591
86centriole assembly (GO:0098534)2.90687966
87gamete generation (GO:0007276)2.89768730
88positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.88430791
89auditory receptor cell stereocilium organization (GO:0060088)2.86776964
90S-adenosylmethionine metabolic process (GO:0046500)2.86631729
91regulation of meiosis I (GO:0060631)2.86197966
92L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85903871
93pseudouridine synthesis (GO:0001522)2.85041000
94protein localization to cilium (GO:0061512)2.84361191
95gamma-aminobutyric acid transport (GO:0015812)2.82689736
96pore complex assembly (GO:0046931)2.82682254
97retinal cone cell development (GO:0046549)2.82652864
98behavioral response to ethanol (GO:0048149)2.80977585
99sister chromatid cohesion (GO:0007062)2.80853383
100regulation of heat generation (GO:0031650)2.80598422
101preassembly of GPI anchor in ER membrane (GO:0016254)2.79881573
102cytochrome complex assembly (GO:0017004)2.79318776
103neural tube formation (GO:0001841)2.78404734
104mitochondrial respiratory chain complex assembly (GO:0033108)2.78079719
105regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.77435779
106histone H2A acetylation (GO:0043968)2.77415613
107interferon-gamma production (GO:0032609)2.77124259
108rRNA catabolic process (GO:0016075)2.76513998
109rhodopsin mediated signaling pathway (GO:0016056)2.76457245
110histamine secretion (GO:0001821)2.75312519
111meiosis I (GO:0007127)2.73686932
112nonmotile primary cilium assembly (GO:0035058)2.71588208
113regulation of action potential (GO:0098900)2.71432605
114organic cation transport (GO:0015695)2.71168860
115genitalia morphogenesis (GO:0035112)2.71019509
116replication fork processing (GO:0031297)2.70444425
117reciprocal DNA recombination (GO:0035825)2.69258837
118reciprocal meiotic recombination (GO:0007131)2.69258837
119regulation of rhodopsin mediated signaling pathway (GO:0022400)2.68587742
120replicative senescence (GO:0090399)2.68175367
121DNA synthesis involved in DNA repair (GO:0000731)2.67584580
122dopamine transport (GO:0015872)2.67132867
123amine catabolic process (GO:0009310)2.66564223
124cellular biogenic amine catabolic process (GO:0042402)2.66564223
125cilium organization (GO:0044782)2.64956357
126amino acid salvage (GO:0043102)2.64873927
127L-methionine salvage (GO:0071267)2.64873927
128L-methionine biosynthetic process (GO:0071265)2.64873927
129histone exchange (GO:0043486)2.63819597
130chromosome condensation (GO:0030261)2.62849509
131cellular process involved in reproduction in multicellular organism (GO:0022412)2.62523939
132glycerophospholipid catabolic process (GO:0046475)2.61906140
133regulation of glucokinase activity (GO:0033131)2.61297343
134regulation of hexokinase activity (GO:1903299)2.61297343
135positive regulation of monocyte chemotaxis (GO:0090026)2.60919650
136DNA double-strand break processing (GO:0000729)2.60601319
137phosphatidylinositol acyl-chain remodeling (GO:0036149)2.60557160
138intraciliary transport (GO:0042073)2.60147069
139meiotic cell cycle process (GO:1903046)2.60083473
140sulfation (GO:0051923)2.59511052
141negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59006254
142negative regulation of reactive oxygen species metabolic process (GO:2000378)2.57955363
143kinetochore organization (GO:0051383)2.57745674
144negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56923902
145positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.56559153
146cellular response to zinc ion (GO:0071294)2.56355816
147cilium assembly (GO:0042384)2.56146414
148microtubule polymerization or depolymerization (GO:0031109)2.55841152
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55342292
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55342292
151DNA strand renaturation (GO:0000733)2.55285563
152negative regulation of DNA-dependent DNA replication (GO:2000104)2.53986136
153indole-containing compound metabolic process (GO:0042430)2.53852966
154kidney morphogenesis (GO:0060993)2.52954316
155regulation of fever generation (GO:0031620)2.52914066
156proline transport (GO:0015824)2.52683164
157interferon-gamma secretion (GO:0072643)2.51041727
158photoreceptor cell development (GO:0042461)2.50629733
159tachykinin receptor signaling pathway (GO:0007217)2.50384253
160startle response (GO:0001964)2.49317011
161neuronal action potential (GO:0019228)2.49258887
162positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49158866
163energy homeostasis (GO:0097009)2.48820176
164histone H3-K9 methylation (GO:0051567)2.48740907
165maturation of 5.8S rRNA (GO:0000460)2.48354819
166ubiquinone biosynthetic process (GO:0006744)2.47546693
167response to muramyl dipeptide (GO:0032495)2.47317952
168reflex (GO:0060004)2.46662370
169monoubiquitinated protein deubiquitination (GO:0035520)2.46451413
170positive regulation of heat generation (GO:0031652)2.46408520
171germ cell development (GO:0007281)2.46387776
172negative regulation of skeletal muscle tissue development (GO:0048642)2.45247236
173chromatin remodeling at centromere (GO:0031055)2.44565474
174alanine transport (GO:0032328)2.44207043
175protein K11-linked deubiquitination (GO:0035871)2.43274962
176histamine transport (GO:0051608)2.42935338
177antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.42713407
178positive regulation of gamma-delta T cell activation (GO:0046645)2.41791827
179pyrimidine dimer repair (GO:0006290)2.41676978
180regulation of interleukin-12 biosynthetic process (GO:0045075)2.41488969
181regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.40256940
182protein localization to chromosome, centromeric region (GO:0071459)2.39471570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.49977053
2E2F7_22180533_ChIP-Seq_HELA_Human4.45860063
3ZNF274_21170338_ChIP-Seq_K562_Hela4.23910312
4VDR_22108803_ChIP-Seq_LS180_Human3.70118666
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.39831195
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.25522536
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19480218
8PCGF2_27294783_Chip-Seq_ESCs_Mouse3.16700769
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.96410111
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.83223735
11PCGF2_27294783_Chip-Seq_NPCs_Mouse2.67957722
12NFE2_27457419_Chip-Seq_LIVER_Mouse2.52258098
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.43012771
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22380450
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.08513281
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.07463292
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01000646
18* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97995307
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.94780859
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.90850722
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89430559
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88074073
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.84307078
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.83982741
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83523499
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.82061488
27STAT3_18555785_Chip-Seq_ESCs_Mouse1.79444302
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.78603219
29BCAT_22108803_ChIP-Seq_LS180_Human1.74591019
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74163595
31SUZ12_18555785_Chip-Seq_ESCs_Mouse1.73800973
32GBX2_23144817_ChIP-Seq_PC3_Human1.73731461
33NMYC_18555785_Chip-Seq_ESCs_Mouse1.71844863
34P53_22387025_ChIP-Seq_ESCs_Mouse1.71836227
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71711003
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71671162
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71227592
38OCT4_18555785_Chip-Seq_ESCs_Mouse1.70347576
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70066887
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69166082
41TP53_22573176_ChIP-Seq_HFKS_Human1.67209130
42IRF1_19129219_ChIP-ChIP_H3396_Human1.65549578
43E2F1_18555785_Chip-Seq_ESCs_Mouse1.64385230
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62532381
45SOX2_18555785_Chip-Seq_ESCs_Mouse1.61150910
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.60030853
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.59549352
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57736099
49STAT3_23295773_ChIP-Seq_U87_Human1.57599807
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.57306981
51EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.57169544
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56748393
53ZFX_18555785_Chip-Seq_ESCs_Mouse1.56126778
54P300_18555785_Chip-Seq_ESCs_Mouse1.55030369
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54639096
56* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54490236
57MYC_18940864_ChIP-ChIP_HL60_Human1.51861261
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51007435
59KLF4_18555785_Chip-Seq_ESCs_Mouse1.49898909
60PU1_27457419_Chip-Seq_LIVER_Mouse1.47371417
61ESRRB_18555785_Chip-Seq_ESCs_Mouse1.46583101
62AR_25329375_ChIP-Seq_VCAP_Human1.44043859
63RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43974319
64SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43681749
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43008735
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.43008735
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42987025
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.42939104
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41690881
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41479128
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39094298
72SMAD4_21799915_ChIP-Seq_A2780_Human1.38976198
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.38588515
74SOX2_19829295_ChIP-Seq_ESCs_Human1.38201150
75NANOG_19829295_ChIP-Seq_ESCs_Human1.38201150
76FUS_26573619_Chip-Seq_HEK293_Human1.37497937
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.36274461
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.35787030
79IGF1R_20145208_ChIP-Seq_DFB_Human1.35786219
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.34463260
81TCF4_22108803_ChIP-Seq_LS180_Human1.33284323
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32511667
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31996772
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.30183190
85SCL_19346495_ChIP-Seq_HPC-7_Human1.29952026
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29919924
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29209278
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28535892
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28236359
90EZH2_22144423_ChIP-Seq_EOC_Human1.27979921
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26894570
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.26774023
93ER_23166858_ChIP-Seq_MCF-7_Human1.26693091
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26396295
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26026623
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24733024
97HOXB7_26014856_ChIP-Seq_BT474_Human1.24571018
98NCOR_22424771_ChIP-Seq_293T_Human1.24300649
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24049851
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23590387
101VDR_23849224_ChIP-Seq_CD4+_Human1.22720361
102REST_21632747_ChIP-Seq_MESCs_Mouse1.22161294
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21838039
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21218755
105STAT1_17558387_ChIP-Seq_HELA_Human1.20885707
106AR_20517297_ChIP-Seq_VCAP_Human1.20880316
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20341414
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20284962
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.18877439
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18847124
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.17657602
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17638705
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.17604283
114RNF2_27304074_Chip-Seq_NSC_Mouse1.17395160
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16904310
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16426125
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14784515
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14784515
119MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14219344
120IRF8_27001747_Chip-Seq_BMDM_Mouse1.13900969
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.13498545
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13230165
123KDM2B_26808549_Chip-Seq_REH_Human1.13188631
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.12807076
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.12434931
126* EWS_26573619_Chip-Seq_HEK293_Human1.12230700
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11208902
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09508673
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07348325
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07115107
131ELK1_19687146_ChIP-ChIP_HELA_Human1.06151001
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05469232
133HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05236223
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04703346
135AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03752461
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02783739
137CBP_20019798_ChIP-Seq_JUKART_Human1.02769517
138IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02769517
139CDX2_22108803_ChIP-Seq_LS180_Human1.02534856
140MYC_19829295_ChIP-Seq_ESCs_Human1.00736003
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00610457
142STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00502977
143KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00271629
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99569116
145* TCF4_23295773_ChIP-Seq_U87_Human0.99338651
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98269426
147LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97711950
148ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97667532
149ERA_21632823_ChIP-Seq_H3396_Human0.96655862
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96378127
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96038308
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95385572
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.94789209
154P300_19829295_ChIP-Seq_ESCs_Human0.94623638
155NFYB_21822215_ChIP-Seq_K562_Human0.94444700
156ETV1_20927104_ChIP-Seq_GIST48_Human0.94198885
157TAF15_26573619_Chip-Seq_HEK293_Human0.93477743
158SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92470706
159PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91589932
160GF1_26923725_Chip-Seq_HPCs_Mouse0.91223174
161FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91187817
162VDR_24787735_ChIP-Seq_THP-1_Human0.89165098
163LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88206784
164MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87624783
165TBL1_22424771_ChIP-Seq_293T_Human0.87287995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.90107698
2MP0008877_abnormal_DNA_methylation4.19204007
3MP0005670_abnormal_white_adipose3.48690299
4MP0003136_yellow_coat_color3.36197845
5MP0000566_synostosis2.83382650
6MP0002132_abnormal_respiratory_system2.69995673
7MP0001929_abnormal_gametogenesis2.67214752
8MP0005551_abnormal_eye_electrophysiolog2.56881206
9MP0003195_calcinosis2.55443787
10MP0003698_abnormal_male_reproductive2.50323585
11MP0001835_abnormal_antigen_presentation2.46463337
12MP0002102_abnormal_ear_morphology2.26833220
13MP0003646_muscle_fatigue2.26235763
14MP0008057_abnormal_DNA_replication2.19543795
15MP0002736_abnormal_nociception_after2.13913547
16MP0009046_muscle_twitch2.10125581
17MP0005174_abnormal_tail_pigmentation2.09812441
18MP0001545_abnormal_hematopoietic_system2.08668307
19MP0005397_hematopoietic_system_phenotyp2.08668307
20MP0002638_abnormal_pupillary_reflex2.04969769
21MP0003787_abnormal_imprinting2.03864761
22MP0006072_abnormal_retinal_apoptosis2.01412312
23MP0002210_abnormal_sex_determination1.99417265
24MP0008872_abnormal_physiological_respon1.97932596
25MP0009785_altered_susceptibility_to1.96700232
26MP0010094_abnormal_chromosome_stability1.96682578
27MP0005671_abnormal_response_to1.92345578
28MP0002837_dystrophic_cardiac_calcinosis1.89769319
29MP0004885_abnormal_endolymph1.87072486
30MP0001986_abnormal_taste_sensitivity1.83795471
31MP0008875_abnormal_xenobiotic_pharmacok1.83729996
32MP0008058_abnormal_DNA_repair1.82804369
33MP0009745_abnormal_behavioral_response1.81576373
34MP0002148_abnormal_hypersensitivity_rea1.80757959
35MP0005253_abnormal_eye_physiology1.79643834
36MP0005451_abnormal_body_composition1.77413259
37MP0000427_abnormal_hair_cycle1.66858053
38MP0002272_abnormal_nervous_system1.66695572
39MP0002419_abnormal_innate_immunity1.66212976
40MP0005666_abnormal_adipose_tissue1.63632027
41MP0001501_abnormal_sleep_pattern1.63386050
42MP0001853_heart_inflammation1.59396707
43MP0001486_abnormal_startle_reflex1.58039497
44MP0004808_abnormal_hematopoietic_stem1.55253068
45MP0004142_abnormal_muscle_tone1.54476124
46MP0000372_irregular_coat_pigmentation1.54172246
47MP0006292_abnormal_olfactory_placode1.53803467
48MP0005389_reproductive_system_phenotype1.51532385
49MP0002938_white_spotting1.51356582
50MP0003763_abnormal_thymus_physiology1.51120497
51MP0003724_increased_susceptibility_to1.50573019
52MP0004043_abnormal_pH_regulation1.49271721
53MP0005025_abnormal_response_to1.48553477
54MP0001800_abnormal_humoral_immune1.47210498
55MP0004130_abnormal_muscle_cell1.47046662
56MP0005379_endocrine/exocrine_gland_phen1.45769774
57MP0005084_abnormal_gallbladder_morpholo1.45716528
58MP0001485_abnormal_pinna_reflex1.44190670
59MP0002452_abnormal_antigen_presenting1.43844164
60MP0008995_early_reproductive_senescence1.42007757
61MP0003111_abnormal_nucleus_morphology1.40943952
62MP0002163_abnormal_gland_morphology1.40421772
63MP0001145_abnormal_male_reproductive1.38991315
64MP0001188_hyperpigmentation1.38439773
65MP0003880_abnormal_central_pattern1.38267193
66MP0005000_abnormal_immune_tolerance1.37612765
67MP0002876_abnormal_thyroid_physiology1.36512656
68MP0002420_abnormal_adaptive_immunity1.36496655
69MP0002723_abnormal_immune_serum1.36172229
70MP0001819_abnormal_immune_cell1.35841799
71MP0006276_abnormal_autonomic_nervous1.35430717
72MP0005377_hearing/vestibular/ear_phenot1.34569320
73MP0003878_abnormal_ear_physiology1.34569320
74MP0010386_abnormal_urinary_bladder1.34134968
75MP0001790_abnormal_immune_system1.32702697
76MP0005387_immune_system_phenotype1.32702697
77MP0000569_abnormal_digit_pigmentation1.32325441
78MP0000631_abnormal_neuroendocrine_gland1.31898251
79MP0005646_abnormal_pituitary_gland1.31751687
80MP0008004_abnormal_stomach_pH1.30179540
81MP0005423_abnormal_somatic_nervous1.28725968
82MP0003077_abnormal_cell_cycle1.27577303
83MP0000653_abnormal_sex_gland1.27363398
84MP0004147_increased_porphyrin_level1.25625845
85MP0008007_abnormal_cellular_replicative1.24915379
86MP0000490_abnormal_crypts_of1.24345766
87MP0004742_abnormal_vestibular_system1.23510119
88MP0001919_abnormal_reproductive_system1.22784153
89MP0002161_abnormal_fertility/fecundity1.20439637
90MP0002572_abnormal_emotion/affect_behav1.19724581
91MP0000383_abnormal_hair_follicle1.18451399
92MP0003786_premature_aging1.16750584
93MP0001970_abnormal_pain_threshold1.15657540
94MP0005171_absent_coat_pigmentation1.15454446
95MP0002735_abnormal_chemical_nociception1.15406363
96MP0002733_abnormal_thermal_nociception1.14876011
97MP0002138_abnormal_hepatobiliary_system1.14041947
98MP0002398_abnormal_bone_marrow1.13588865
99MP0002557_abnormal_social/conspecific_i1.13445418
100MP0002064_seizures1.12935307
101MP0003436_decreased_susceptibility_to1.12211371
102MP0002405_respiratory_system_inflammati1.09891438
103MP0003718_maternal_effect1.09659049
104MP0000015_abnormal_ear_pigmentation1.09168376
105MP0005167_abnormal_blood-brain_barrier1.08768263
106MP0004133_heterotaxia1.08699444
107MP0009278_abnormal_bone_marrow1.07609903
108MP0000716_abnormal_immune_system1.05953756
109MP0005386_behavior/neurological_phenoty1.05377932
110MP0004924_abnormal_behavior1.05377932
111MP0003121_genomic_imprinting1.04279778
112MP0003693_abnormal_embryo_hatching1.03277548
113MP0002067_abnormal_sensory_capabilities1.02204262
114MP0009115_abnormal_fat_cell1.01792801
115MP0005075_abnormal_melanosome_morpholog1.01389003
116MP0002928_abnormal_bile_duct1.00679424
117MP0001764_abnormal_homeostasis0.98992920
118MP0002234_abnormal_pharynx_morphology0.95666671
119MP0002006_tumorigenesis0.94421889
120MP0004145_abnormal_muscle_electrophysio0.93929228
121MP0003941_abnormal_skin_development0.93794604
122MP0002229_neurodegeneration0.91539752
123MP0005645_abnormal_hypothalamus_physiol0.91508758
124MP0003635_abnormal_synaptic_transmissio0.90116830
125MP0004215_abnormal_myocardial_fiber0.90054343
126MP0001529_abnormal_vocalization0.87237493
127MP0001502_abnormal_circadian_rhythm0.87179173
128MP0001119_abnormal_female_reproductive0.86739847
129MP0002396_abnormal_hematopoietic_system0.86595813
130MP0002063_abnormal_learning/memory/cond0.86374616
131MP0005195_abnormal_posterior_eye0.86213381
132MP0005409_darkened_coat_color0.85685416
133MP0001905_abnormal_dopamine_level0.85461671
134MP0000689_abnormal_spleen_morphology0.85189750
135MP0002429_abnormal_blood_cell0.85110439
136MP0002160_abnormal_reproductive_system0.85100851
137MP0009697_abnormal_copulation0.84637342
138MP0001984_abnormal_olfaction0.84432285
139MP0003137_abnormal_impulse_conducting0.83520060
140MP0003011_delayed_dark_adaptation0.82013025
141MP0003186_abnormal_redox_activity0.80860464
142MP0002095_abnormal_skin_pigmentation0.80362704
143MP0002653_abnormal_ependyma_morphology0.79772264
144MP0003045_fibrosis0.79485829
145MP0000685_abnormal_immune_system0.78789808
146MP0006054_spinal_hemorrhage0.78071872
147MP0002971_abnormal_brown_adipose0.78049688
148MP0002752_abnormal_somatic_nervous0.77919378
149MP0002722_abnormal_immune_system0.77573503
150MP0003119_abnormal_digestive_system0.76766738
151MP0003656_abnormal_erythrocyte_physiolo0.76059690
152MP0001968_abnormal_touch/_nociception0.75159622
153MP0008775_abnormal_heart_ventricle0.73505981
154MP0004381_abnormal_hair_follicle0.71749914
155MP0006036_abnormal_mitochondrial_physio0.71269301
156MP0002734_abnormal_mechanical_nocicepti0.70855892
157MP0002751_abnormal_autonomic_nervous0.70274006
158MP0001963_abnormal_hearing_physiology0.70002329
159MP0003690_abnormal_glial_cell0.68231021
160MP0010155_abnormal_intestine_physiology0.67203081
161MP0010307_abnormal_tumor_latency0.67161221
162MP0009333_abnormal_splenocyte_physiolog0.67001985
163MP0000343_altered_response_to0.64998346
164MP0009764_decreased_sensitivity_to0.63868485
165MP0002075_abnormal_coat/hair_pigmentati0.61511560

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.99436634
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.33257106
3Absent/shortened dynein arms (HP:0200106)6.33257106
4Abnormal respiratory motile cilium physiology (HP:0012261)5.06853378
5Abnormal respiratory epithelium morphology (HP:0012253)4.73139429
6Abnormal respiratory motile cilium morphology (HP:0005938)4.73139429
7Pancreatic cysts (HP:0001737)4.50626939
8Abnormal ciliary motility (HP:0012262)4.36311384
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.18860883
10Chromsome breakage (HP:0040012)4.08245872
11Congenital stationary night blindness (HP:0007642)4.07758695
12Rhinitis (HP:0012384)3.99365438
13Renal cortical cysts (HP:0000803)3.29376395
14Optic neuritis (HP:0100653)3.23227040
15Retrobulbar optic neuritis (HP:0100654)3.23227040
16Recurrent sinusitis (HP:0011108)3.14417968
17Nephronophthisis (HP:0000090)3.12826419
18Chronic hepatic failure (HP:0100626)3.05005621
19Abnormality of the preputium (HP:0100587)3.04854815
20Attenuation of retinal blood vessels (HP:0007843)3.03079108
21Hyperventilation (HP:0002883)2.93524340
22Abolished electroretinogram (ERG) (HP:0000550)2.92986702
23Cystic liver disease (HP:0006706)2.91974503
24Chronic bronchitis (HP:0004469)2.86922448
25Abnormal spermatogenesis (HP:0008669)2.86591068
26Abnormality of the renal cortex (HP:0011035)2.76795706
27Tubular atrophy (HP:0000092)2.75932915
28Type II lissencephaly (HP:0007260)2.75755410
29Abnormal rod and cone electroretinograms (HP:0008323)2.73916761
30Abnormality of the renal collecting system (HP:0004742)2.72830392
31Duplicated collecting system (HP:0000081)2.72087623
32True hermaphroditism (HP:0010459)2.70432994
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.69512006
34Meckel diverticulum (HP:0002245)2.69213072
35Bronchiectasis (HP:0002110)2.67609469
36Nasal polyposis (HP:0100582)2.66066243
37Pendular nystagmus (HP:0012043)2.65152977
38Ectopic kidney (HP:0000086)2.64332506
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.62642425
40Polydipsia (HP:0001959)2.60788365
41Abnormal drinking behavior (HP:0030082)2.60788365
42Panhypogammaglobulinemia (HP:0003139)2.60573735
43Orchitis (HP:0100796)2.58800604
44Infertility (HP:0000789)2.57938579
4511 pairs of ribs (HP:0000878)2.57486230
46Abnormality of the ileum (HP:0001549)2.56674191
47Abnormality of chromosome stability (HP:0003220)2.56462160
48Tubulointerstitial nephritis (HP:0001970)2.52574345
49Recurrent abscess formation (HP:0002722)2.50358030
50Myositis (HP:0100614)2.50296781
51Recurrent otitis media (HP:0000403)2.49018875
52Agammaglobulinemia (HP:0004432)2.48140778
53Inability to walk (HP:0002540)2.48103398
54Abnormality of the carotid arteries (HP:0005344)2.47098554
55Abnormality of the renal medulla (HP:0100957)2.46490482
56Abnormality of DNA repair (HP:0003254)2.43812629
57Hyperalaninemia (HP:0003348)2.41255939
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41255939
59Abnormality of alanine metabolism (HP:0010916)2.41255939
60Clubbing of toes (HP:0100760)2.39459010
61Sclerocornea (HP:0000647)2.37157172
62Gaze-evoked nystagmus (HP:0000640)2.36269424
63Increased corneal curvature (HP:0100692)2.34923460
64Keratoconus (HP:0000563)2.34923460
65Gait imbalance (HP:0002141)2.34041723
66Large for gestational age (HP:0001520)2.33546356
67Increased CSF lactate (HP:0002490)2.33464129
68Acute necrotizing encephalopathy (HP:0006965)2.32355644
69Progressive inability to walk (HP:0002505)2.28544219
70Azoospermia (HP:0000027)2.26637659
71Bronchitis (HP:0012387)2.25933175
72Aplasia/Hypoplasia of the tongue (HP:0010295)2.24790018
73Keratoconjunctivitis sicca (HP:0001097)2.22902922
74Mitochondrial inheritance (HP:0001427)2.21332852
75Abnormal biliary tract physiology (HP:0012439)2.20865542
76Bile duct proliferation (HP:0001408)2.20865542
77Median cleft lip (HP:0000161)2.20858800
78Febrile seizures (HP:0002373)2.20630193
79Medial flaring of the eyebrow (HP:0010747)2.19252932
80Protruding tongue (HP:0010808)2.18588725
81Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18251412
82Recurrent bacterial skin infections (HP:0005406)2.17901955
83Decreased central vision (HP:0007663)2.17705062
84Cerebellar dysplasia (HP:0007033)2.17686190
85Thyroid-stimulating hormone excess (HP:0002925)2.14768350
86Progressive macrocephaly (HP:0004481)2.13779783
87Anencephaly (HP:0002323)2.13729768
88Polyuria (HP:0000103)2.12956473
89Furrowed tongue (HP:0000221)2.09975024
90Chronic mucocutaneous candidiasis (HP:0002728)2.09748524
91Recurrent cutaneous fungal infections (HP:0011370)2.09748524
92Sloping forehead (HP:0000340)2.08443569
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.08120606
94Methylmalonic acidemia (HP:0002912)2.08105609
95Fair hair (HP:0002286)2.07082328
96Toxemia of pregnancy (HP:0100603)2.06865594
97Broad-based gait (HP:0002136)2.06425274
98Acute encephalopathy (HP:0006846)2.03692381
99Thrombocytosis (HP:0001894)2.02678947
100Encephalitis (HP:0002383)2.01191959
101Progressive cerebellar ataxia (HP:0002073)1.98260017
102Optic disc pallor (HP:0000543)1.97644768
103Duodenal stenosis (HP:0100867)1.97563395
104Small intestinal stenosis (HP:0012848)1.97563395
105Optic nerve hypoplasia (HP:0000609)1.96362073
106Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96182653
107Chronic sinusitis (HP:0011109)1.95703825
108Meningitis (HP:0001287)1.95407028
109Abnormal glycosylation (HP:0012345)1.95156281
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95156281
111Abnormal protein N-linked glycosylation (HP:0012347)1.95156281
112Abnormal protein glycosylation (HP:0012346)1.95156281
113Chronic obstructive pulmonary disease (HP:0006510)1.94112850
114Obstructive lung disease (HP:0006536)1.94112850
115Keratoconjunctivitis (HP:0001096)1.94006320
116Genetic anticipation (HP:0003743)1.93423514
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92233638
118Abnormal mitochondria in muscle tissue (HP:0008316)1.91487190
119Fibular hypoplasia (HP:0003038)1.91351484
120Methylmalonic aciduria (HP:0012120)1.91305401
121Occipital encephalocele (HP:0002085)1.91111720
122Congenital, generalized hypertrichosis (HP:0004540)1.90873606
123Autoimmune thrombocytopenia (HP:0001973)1.89082709
124Inflammation of the large intestine (HP:0002037)1.88881368
125Lissencephaly (HP:0001339)1.88822696
126Bony spicule pigmentary retinopathy (HP:0007737)1.88124138
127Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87623979
128Reduced antithrombin III activity (HP:0001976)1.87618474
129Genital tract atresia (HP:0001827)1.87398375
130Aplasia/Hypoplasia of the spleen (HP:0010451)1.85725207
131Male pseudohermaphroditism (HP:0000037)1.85687367
132Recurrent pneumonia (HP:0006532)1.85463777
133Recurrent bronchitis (HP:0002837)1.85273661
134Thyroiditis (HP:0100646)1.84338659
135Nausea (HP:0002018)1.84290104
136Hepatocellular necrosis (HP:0001404)1.83487710
137Hypothermia (HP:0002045)1.82588812
138Clumsiness (HP:0002312)1.81285037
139Colitis (HP:0002583)1.81006866
140Gonadotropin excess (HP:0000837)1.80927294
141Vaginal atresia (HP:0000148)1.80607069
142Congenital hepatic fibrosis (HP:0002612)1.78660615
143Recurrent viral infections (HP:0004429)1.78490615
144Postaxial foot polydactyly (HP:0001830)1.78331496
145Severe muscular hypotonia (HP:0006829)1.77495028
146Recurrent fungal infections (HP:0002841)1.76785160
147Decreased circulating renin level (HP:0003351)1.75576436
148Small hand (HP:0200055)1.75434881
149Molar tooth sign on MRI (HP:0002419)1.75433735
150Abnormality of midbrain morphology (HP:0002418)1.75433735
151Stomach cancer (HP:0012126)1.75050891
152Abnormality of the pons (HP:0007361)1.74995462
153Pancreatic fibrosis (HP:0100732)1.74625709
154Myelodysplasia (HP:0002863)1.74617480
155Abnormality of macular pigmentation (HP:0008002)1.73959590
156Increased serum lactate (HP:0002151)1.73046184
157Hypoplasia of the pons (HP:0012110)1.73036168
158Oligodactyly (hands) (HP:0001180)1.71648258
159Hepatic necrosis (HP:0002605)1.71108114
160Recurrent lower respiratory tract infections (HP:0002783)1.71023646
161Hyperglycinuria (HP:0003108)1.70985993
162Hypergonadotropic hypogonadism (HP:0000815)1.70282936
163Hemiparesis (HP:0001269)1.69195127
164Vasculitis (HP:0002633)1.68907970
165Absent thumb (HP:0009777)1.68324531
166Abnormality of the nasal mucosa (HP:0000433)1.66123832
167Hypoplasia of the fovea (HP:0007750)1.65590859
168Aplasia/Hypoplasia of the fovea (HP:0008060)1.65590859
169Birth length less than 3rd percentile (HP:0003561)1.65466534
170Acute myeloid leukemia (HP:0004808)1.64068902
171Selective tooth agenesis (HP:0001592)1.63694473
172Elevated erythrocyte sedimentation rate (HP:0003565)1.63268934
173Nephrogenic diabetes insipidus (HP:0009806)1.62289648
174Albinism (HP:0001022)1.62156987
175Gastrointestinal inflammation (HP:0004386)1.61676958
176Type I transferrin isoform profile (HP:0003642)1.60709152
177Congenital primary aphakia (HP:0007707)1.60014106
178Recurrent skin infections (HP:0001581)1.59875956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.57962822
2PDK35.57962822
3FRK5.50993881
4PDK23.57280166
5PRPF4B2.86229488
6TXK2.71653503
7PNCK2.65538595
8STK38L2.63057343
9MAP4K22.62213753
10TNIK2.59603396
11EIF2AK12.41800561
12IRAK32.37065044
13WNK42.32116110
14WNK32.23627388
15ZAK2.04023062
16LATS11.96134935
17OXSR11.95532878
18MAP3K141.94897885
19MAP3K61.72445452
20NEK21.68368031
21STK161.64624686
22MAPK131.64230066
23MAP3K41.61475485
24EIF2AK21.61264292
25MAP2K61.58403563
26INSRR1.58139780
27PTK2B1.55289041
28SRPK11.53784782
29STK31.50606193
30STK391.50600574
31CDK31.41148785
32TRPM71.40916360
33MAP4K11.31354278
34BMPR1B1.30303636
35DAPK21.28948696
36TTK1.28008758
37VRK11.27942896
38TIE11.27545502
39BRSK21.26028875
40TRIM281.24217248
41ATR1.20728597
42PLK21.20427301
43IRAK41.20209297
44YES11.18042259
45PAK31.16430661
46CASK1.13596041
47BCKDK1.10693312
48MKNK21.10290640
49ADRBK11.08912293
50NTRK31.08034301
51JAK31.05049383
52CDC71.04353387
53TEC1.02078923
54TGFBR11.01720216
55TAOK31.01025086
56RIPK41.00685381
57PINK10.97276258
58CSNK1G20.96496588
59MAP2K70.94931531
60PRKCE0.93500429
61CLK10.93492795
62ADRBK20.89459833
63KIT0.88779508
64NEK90.86324917
65PRKCG0.86167945
66CSNK1G10.85625605
67CSNK1G30.84634329
68MAP2K30.84093075
69TAOK20.82352568
70IKBKB0.81169181
71PLK40.79540848
72DYRK20.78838522
73CAMKK20.76220486
74BTK0.74430303
75RPS6KA40.73428800
76STK40.72863859
77PHKG10.72853165
78PHKG20.72853165
79MAPKAPK30.72680073
80RPS6KB10.72455450
81PLK10.72346198
82LMTK20.70914642
83MST40.70876558
84TBK10.70183544
85MET0.69387676
86STK380.68878411
87PRKCI0.68182564
88OBSCN0.66829335
89LYN0.66384677
90NEK60.66376705
91ZAP700.65850729
92CSNK1A1L0.65795552
93NLK0.65215511
94WEE10.65119080
95MUSK0.63874211
96ATM0.63828852
97MAPK150.63192291
98CHUK0.63089018
99RPS6KA50.62293094
100PLK30.61764156
101PIK3CA0.61107001
102MAPK70.60718275
103SGK20.60699278
104MAP3K50.60386922
105JAK10.59208386
106PRKD30.58944413
107PDK10.58503958
108PRKCQ0.57855076
109GRK10.57337743
110NTRK20.56911668
111FLT30.56812820
112AURKB0.56696115
113IKBKE0.55677005
114EPHA40.55357767
115TESK10.55193602
116CSF1R0.54841328
117CHEK10.53430628
118MARK10.52573278
119BCR0.52379712
120NUAK10.52372542
121CCNB10.51966797
122BRSK10.51493776
123ACVR1B0.51490359
124SYK0.51203116
125AKT30.50941839
126CAMK1D0.50045237
127EEF2K0.49440200
128CAMK10.49025834
129MAP3K120.48831913
130PRKAA20.48720195
131MAPKAPK50.48577778
132CAMK1G0.48534846
133SIK30.48052764
134TSSK60.47397805
135STK110.46094793
136MELK0.45304208
137LCK0.44590545
138PKN10.44325576
139FGFR20.44124854
140MKNK10.43548036
141VRK20.43393228
142BRD40.42833323
143CDK90.42692502
144PBK0.42585263
145EIF2AK30.42527979
146MAPK110.42233810
147TLK10.41974054
148CAMK2A0.41292370
149CHEK20.41023501
150TYK20.40087001
151TNK20.38110265
152STK100.37944065
153FER0.37828839
154IRAK10.37553683
155SGK10.36263803
156CSNK1A10.36024785
157NME10.35934606
158MARK30.35550149
159CDK190.35510482
160BMPR20.35312340
161CDK80.34848768
162TAF10.34480603
163GRK50.32798882
164PRKACA0.32574697
165ITK0.31826991
166CSNK1D0.30278703
167PRKCA0.27108128

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.27163074
2* Fanconi anemia pathway_Homo sapiens_hsa034603.06410553
3Phototransduction_Homo sapiens_hsa047443.05391122
4Propanoate metabolism_Homo sapiens_hsa006402.98709298
5Homologous recombination_Homo sapiens_hsa034402.74764199
6Non-homologous end-joining_Homo sapiens_hsa034502.68216864
7DNA replication_Homo sapiens_hsa030302.63282659
8Nitrogen metabolism_Homo sapiens_hsa009102.60367060
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.54457033
10Primary immunodeficiency_Homo sapiens_hsa053402.32889935
11Butanoate metabolism_Homo sapiens_hsa006502.31013833
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24231573
13Selenocompound metabolism_Homo sapiens_hsa004502.17476400
14Allograft rejection_Homo sapiens_hsa053302.16119495
15Base excision repair_Homo sapiens_hsa034102.08956184
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01263781
17RNA polymerase_Homo sapiens_hsa030201.96840894
18Protein export_Homo sapiens_hsa030601.95240229
19Vitamin B6 metabolism_Homo sapiens_hsa007501.88104280
20Nicotine addiction_Homo sapiens_hsa050331.87438606
21Ether lipid metabolism_Homo sapiens_hsa005651.86208310
22Graft-versus-host disease_Homo sapiens_hsa053321.84321298
23Oxidative phosphorylation_Homo sapiens_hsa001901.82912313
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77589699
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77405284
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.75459483
27Basal transcription factors_Homo sapiens_hsa030221.73034469
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.69150126
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.67730457
30Tryptophan metabolism_Homo sapiens_hsa003801.64430064
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64271634
32Fatty acid metabolism_Homo sapiens_hsa012121.64108508
33Fatty acid degradation_Homo sapiens_hsa000711.58543481
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56039201
35Mismatch repair_Homo sapiens_hsa034301.55965419
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52112447
37Herpes simplex infection_Homo sapiens_hsa051681.50917670
38Pyruvate metabolism_Homo sapiens_hsa006201.46936194
39Measles_Homo sapiens_hsa051621.46555817
40Taste transduction_Homo sapiens_hsa047421.43706516
41Legionellosis_Homo sapiens_hsa051341.38416687
42Autoimmune thyroid disease_Homo sapiens_hsa053201.38358827
43RNA degradation_Homo sapiens_hsa030181.37618313
44Leishmaniasis_Homo sapiens_hsa051401.35822256
45PPAR signaling pathway_Homo sapiens_hsa033201.35659770
46Hematopoietic cell lineage_Homo sapiens_hsa046401.35036569
47Olfactory transduction_Homo sapiens_hsa047401.34541236
48Pentose phosphate pathway_Homo sapiens_hsa000301.31653613
49Parkinsons disease_Homo sapiens_hsa050121.30223338
50Caffeine metabolism_Homo sapiens_hsa002321.29331690
51Morphine addiction_Homo sapiens_hsa050321.28806437
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28516873
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27019945
54Influenza A_Homo sapiens_hsa051641.24823046
55Cell cycle_Homo sapiens_hsa041101.23484331
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21859671
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19829888
58Regulation of autophagy_Homo sapiens_hsa041401.18567400
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17098608
60Type I diabetes mellitus_Homo sapiens_hsa049401.13250695
61NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12626381
62Asthma_Homo sapiens_hsa053101.11808921
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.08147163
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06534237
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05567990
66ABC transporters_Homo sapiens_hsa020101.04239316
67Purine metabolism_Homo sapiens_hsa002301.02871337
68Antigen processing and presentation_Homo sapiens_hsa046120.99571412
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.99480416
70Malaria_Homo sapiens_hsa051440.98830058
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98473080
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.97761809
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97522335
74Collecting duct acid secretion_Homo sapiens_hsa049660.95294985
75Retinol metabolism_Homo sapiens_hsa008300.94520210
76Arachidonic acid metabolism_Homo sapiens_hsa005900.94366022
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94273712
78Nucleotide excision repair_Homo sapiens_hsa034200.94094808
79GABAergic synapse_Homo sapiens_hsa047270.93225725
80p53 signaling pathway_Homo sapiens_hsa041150.92531092
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91916573
82Serotonergic synapse_Homo sapiens_hsa047260.91470987
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91450389
84Chemical carcinogenesis_Homo sapiens_hsa052040.91365800
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90723178
86B cell receptor signaling pathway_Homo sapiens_hsa046620.89380201
87Insulin secretion_Homo sapiens_hsa049110.86837167
88Tuberculosis_Homo sapiens_hsa051520.86439566
89Renin-angiotensin system_Homo sapiens_hsa046140.86029213
90Glutamatergic synapse_Homo sapiens_hsa047240.85915546
91Ovarian steroidogenesis_Homo sapiens_hsa049130.83667374
92Other glycan degradation_Homo sapiens_hsa005110.83424197
93Pyrimidine metabolism_Homo sapiens_hsa002400.82703277
94Circadian entrainment_Homo sapiens_hsa047130.82457515
95Lysine degradation_Homo sapiens_hsa003100.82365088
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82159805
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81295975
98Rheumatoid arthritis_Homo sapiens_hsa053230.81227927
99Dorso-ventral axis formation_Homo sapiens_hsa043200.79281067
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78953793
101Osteoclast differentiation_Homo sapiens_hsa043800.78027176
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77895217
103Huntingtons disease_Homo sapiens_hsa050160.76113433
104Toxoplasmosis_Homo sapiens_hsa051450.75344948
105Sphingolipid metabolism_Homo sapiens_hsa006000.74507549
106Cardiac muscle contraction_Homo sapiens_hsa042600.74044376
107Fat digestion and absorption_Homo sapiens_hsa049750.72865952
108Carbon metabolism_Homo sapiens_hsa012000.71296485
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70846225
110Proteasome_Homo sapiens_hsa030500.70099675
111TNF signaling pathway_Homo sapiens_hsa046680.68759565
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.67575842
113Alzheimers disease_Homo sapiens_hsa050100.67250802
114Glycerolipid metabolism_Homo sapiens_hsa005610.66598254
115Glucagon signaling pathway_Homo sapiens_hsa049220.66011620
116Salivary secretion_Homo sapiens_hsa049700.65185092
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64415309
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64137551
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63357051
120Systemic lupus erythematosus_Homo sapiens_hsa053220.63184688
121Metabolic pathways_Homo sapiens_hsa011000.63060304
122Calcium signaling pathway_Homo sapiens_hsa040200.61817263
123Inositol phosphate metabolism_Homo sapiens_hsa005620.60121379
124Epstein-Barr virus infection_Homo sapiens_hsa051690.59537441
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57843220
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.56748011
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56520123
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.55338951
129Sulfur metabolism_Homo sapiens_hsa009200.54192499
130Pertussis_Homo sapiens_hsa051330.52693212
131Circadian rhythm_Homo sapiens_hsa047100.52142721
132African trypanosomiasis_Homo sapiens_hsa051430.51681288
133Dopaminergic synapse_Homo sapiens_hsa047280.51272330
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51252335
135mRNA surveillance pathway_Homo sapiens_hsa030150.49617775
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49081561
137Peroxisome_Homo sapiens_hsa041460.47531751
138Steroid biosynthesis_Homo sapiens_hsa001000.46072185
139Renin secretion_Homo sapiens_hsa049240.45952014
140Histidine metabolism_Homo sapiens_hsa003400.45592223
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45370880
142Mineral absorption_Homo sapiens_hsa049780.44470173
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43878065
144HTLV-I infection_Homo sapiens_hsa051660.43417190
145Hepatitis B_Homo sapiens_hsa051610.42859927
146Small cell lung cancer_Homo sapiens_hsa052220.42722952
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39812409
148Linoleic acid metabolism_Homo sapiens_hsa005910.39507033
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38911609
150Notch signaling pathway_Homo sapiens_hsa043300.38894341
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38808218
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.38793003
153Viral myocarditis_Homo sapiens_hsa054160.38654619
154Sulfur relay system_Homo sapiens_hsa041220.38500530
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.38298419
156RNA transport_Homo sapiens_hsa030130.37856093
157Apoptosis_Homo sapiens_hsa042100.35640338
158Salmonella infection_Homo sapiens_hsa051320.35165521
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35029671
160One carbon pool by folate_Homo sapiens_hsa006700.33988029
161Vitamin digestion and absorption_Homo sapiens_hsa049770.33762563
162Hepatitis C_Homo sapiens_hsa051600.33621509
163T cell receptor signaling pathway_Homo sapiens_hsa046600.32405446
164beta-Alanine metabolism_Homo sapiens_hsa004100.32015768

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