POLQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.46935627
2nuclear pore complex assembly (GO:0051292)5.41046019
3nuclear pore organization (GO:0006999)5.24163958
4mitotic sister chromatid segregation (GO:0000070)5.11287597
5mitotic chromosome condensation (GO:0007076)5.08477920
6sister chromatid segregation (GO:0000819)5.05047874
7mitotic sister chromatid cohesion (GO:0007064)5.03317580
8kinetochore organization (GO:0051383)5.01558506
9protein localization to chromosome, centromeric region (GO:0071459)4.98489576
10mitotic metaphase plate congression (GO:0007080)4.82321377
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.64978305
12DNA replication initiation (GO:0006270)4.51424593
13DNA unwinding involved in DNA replication (GO:0006268)4.46952858
14attachment of spindle microtubules to kinetochore (GO:0008608)4.41051309
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.38537565
16regulation of spindle organization (GO:0090224)4.37430603
17CENP-A containing nucleosome assembly (GO:0034080)4.33137049
18DNA replication checkpoint (GO:0000076)4.31316490
19metaphase plate congression (GO:0051310)4.29140375
20chromatin remodeling at centromere (GO:0031055)4.27584694
21meiotic chromosome segregation (GO:0045132)4.27488061
22regulation of DNA endoreduplication (GO:0032875)4.24390308
23mitotic nuclear envelope disassembly (GO:0007077)4.24382083
24kinetochore assembly (GO:0051382)4.23907728
25DNA ligation (GO:0006266)4.22800804
26DNA replication-independent nucleosome organization (GO:0034724)4.21319833
27DNA replication-independent nucleosome assembly (GO:0006336)4.21319833
28pore complex assembly (GO:0046931)4.18990446
29DNA strand elongation involved in DNA replication (GO:0006271)4.16274888
30DNA replication-dependent nucleosome assembly (GO:0006335)4.09401312
31DNA replication-dependent nucleosome organization (GO:0034723)4.09401312
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.03345554
33DNA strand elongation (GO:0022616)4.00894427
34non-recombinational repair (GO:0000726)3.99793912
35double-strand break repair via nonhomologous end joining (GO:0006303)3.99793912
36regulation of mitotic spindle organization (GO:0060236)3.93955248
37membrane disassembly (GO:0030397)3.93811115
38nuclear envelope disassembly (GO:0051081)3.93811115
39positive regulation of chromosome segregation (GO:0051984)3.92641939
40establishment of chromosome localization (GO:0051303)3.87199526
41histone exchange (GO:0043486)3.84493623
42mitotic recombination (GO:0006312)3.82690071
43regulation of centriole replication (GO:0046599)3.81693779
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.80163172
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.80163172
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.80163172
47translesion synthesis (GO:0019985)3.77613786
48chromatin assembly or disassembly (GO:0006333)3.76671791
49protein localization to chromosome (GO:0034502)3.76348794
50telomere maintenance via semi-conservative replication (GO:0032201)3.75525537
51protein K6-linked ubiquitination (GO:0085020)3.72524289
52regulation of chromosome segregation (GO:0051983)3.70180359
53telomere maintenance via recombination (GO:0000722)3.69133865
54regulation of centrosome cycle (GO:0046605)3.69036395
55synapsis (GO:0007129)3.68603934
56microtubule depolymerization (GO:0007019)3.68585638
57regulation of sister chromatid cohesion (GO:0007063)3.68442575
58regulation of histone H3-K9 methylation (GO:0051570)3.67098972
59spindle checkpoint (GO:0031577)3.66518623
60chromosome segregation (GO:0007059)3.64722394
61DNA strand renaturation (GO:0000733)3.64404262
62establishment of integrated proviral latency (GO:0075713)3.63493784
63DNA double-strand break processing (GO:0000729)3.62005894
64negative regulation of DNA-dependent DNA replication (GO:2000104)3.59536761
65somatic hypermutation of immunoglobulin genes (GO:0016446)3.58344852
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.58344852
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.57439260
68mitotic G2/M transition checkpoint (GO:0044818)3.53118535
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.51038847
70DNA geometric change (GO:0032392)3.49036364
71chromosome condensation (GO:0030261)3.48292174
72DNA duplex unwinding (GO:0032508)3.45536531
73spindle assembly checkpoint (GO:0071173)3.42464821
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.41988576
75centriole replication (GO:0007099)3.41151749
76monoubiquitinated protein deubiquitination (GO:0035520)3.39259860
77DNA packaging (GO:0006323)3.35331299
78negative regulation of chromosome segregation (GO:0051985)3.34767445
79IMP biosynthetic process (GO:0006188)3.33768249
80telomere maintenance (GO:0000723)3.33610302
81regulation of sister chromatid segregation (GO:0033045)3.33249410
82regulation of mitotic sister chromatid separation (GO:0010965)3.33249410
83regulation of mitotic sister chromatid segregation (GO:0033047)3.33249410
84heterochromatin organization (GO:0070828)3.32540850
85DNA synthesis involved in DNA repair (GO:0000731)3.31503222
86nucleobase biosynthetic process (GO:0046112)3.31246329
87telomere organization (GO:0032200)3.31104480
88regulation of RNA export from nucleus (GO:0046831)3.30024164
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.29814638
90negative regulation of sister chromatid segregation (GO:0033046)3.29814638
91negative regulation of mitotic sister chromatid separation (GO:2000816)3.29814638
92negative regulation of mitotic sister chromatid segregation (GO:0033048)3.29814638
93nucleotide-excision repair, DNA gap filling (GO:0006297)3.29019549
94maturation of SSU-rRNA (GO:0030490)3.26895630
95DNA conformation change (GO:0071103)3.25964257
96purine nucleobase biosynthetic process (GO:0009113)3.25478858
97mitotic spindle checkpoint (GO:0071174)3.24639388
98DNA topological change (GO:0006265)3.23670091
99mitotic spindle assembly checkpoint (GO:0007094)3.23173869
100negative regulation of histone methylation (GO:0031061)3.23000688
101pre-miRNA processing (GO:0031054)3.22479313
102ATP-dependent chromatin remodeling (GO:0043044)3.20357132
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18726764
104postreplication repair (GO:0006301)3.17610900
105telomere maintenance via telomere lengthening (GO:0010833)3.16747239
106sister chromatid cohesion (GO:0007062)3.16631861
107replication fork processing (GO:0031297)3.14319427
108regulation of centrosome duplication (GO:0010824)3.13013029
109nuclear envelope organization (GO:0006998)3.08794615
110resolution of meiotic recombination intermediates (GO:0000712)3.06844847
111regulation of double-strand break repair via homologous recombination (GO:0010569)3.06362651
112dosage compensation (GO:0007549)3.00525705
113chromatin assembly (GO:0031497)3.00400631
114histone-serine phosphorylation (GO:0035404)2.98796238
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.97013345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.85303752
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.35282220
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.99298096
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.02107025
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.89541790
6AR_21909140_ChIP-Seq_LNCAP_Human2.87573245
7E2F1_21310950_ChIP-Seq_MCF-7_Human2.85143579
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.63538922
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53628911
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38107075
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36940298
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36091824
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23717913
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23446726
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.05728652
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04369675
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03208474
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02318500
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.01411920
20E2F7_22180533_ChIP-Seq_HELA_Human12.4335935
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.96229558
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89501164
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87989422
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85394109
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82483886
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80887492
27* VDR_23849224_ChIP-Seq_CD4+_Human1.74936618
28MYC_22102868_ChIP-Seq_BL_Human1.71049585
29CIITA_25753668_ChIP-Seq_RAJI_Human1.66649080
30* ETS1_20019798_ChIP-Seq_JURKAT_Human1.65662649
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.63406313
32* ELK1_19687146_ChIP-ChIP_HELA_Human1.56966818
33XRN2_22483619_ChIP-Seq_HELA_Human1.54774523
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52331084
35KDM5A_27292631_Chip-Seq_BREAST_Human1.50405170
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49943888
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46927843
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41415584
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41140861
40TTF2_22483619_ChIP-Seq_HELA_Human1.35555920
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34927854
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32043477
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30879393
44* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30478982
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29421855
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.28876141
47DCP1A_22483619_ChIP-Seq_HELA_Human1.26866020
48E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26176832
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24410350
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23340869
51* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22100687
52GABP_19822575_ChIP-Seq_HepG2_Human1.21052587
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19872856
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17511607
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12213106
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09648491
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08718563
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08437252
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07105473
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06182277
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04978172
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.03168228
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03005829
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02596810
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01724333
66FUS_26573619_Chip-Seq_HEK293_Human0.99999898
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98611367
68SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98298543
69IRF1_19129219_ChIP-ChIP_H3396_Human0.97122218
70TFEB_21752829_ChIP-Seq_HELA_Human0.93874920
71KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92814069
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92561098
73SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91576327
74YY1_21170310_ChIP-Seq_MESCs_Mouse0.90439406
75NANOG_21062744_ChIP-ChIP_HESCs_Human0.90158484
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88093569
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87559457
78MYB_26560356_Chip-Seq_TH1_Human0.87046767
79ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85592488
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85125310
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84986103
82VDR_21846776_ChIP-Seq_THP-1_Human0.84943487
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84478540
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.83486962
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82144123
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82093558
87NANOG_16153702_ChIP-ChIP_HESCs_Human0.80553771
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80529214
89MYC_18940864_ChIP-ChIP_HL60_Human0.77778470
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77583896
91* SPI1_23547873_ChIP-Seq_NB4_Human0.76668105
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75724295
93PKCTHETA_26484144_Chip-Seq_BREAST_Human0.74923292
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.74860359
95EWS_26573619_Chip-Seq_HEK293_Human0.72387051
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71994840
97* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.69231012
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.69018792
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.68508475
100MYB_21317192_ChIP-Seq_ERMYB_Mouse0.68416706
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.68202773
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.68042913
103FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.67512482
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66120638
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.64024876
106MYB_26560356_Chip-Seq_TH2_Human0.63477268
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.62795403
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.62664194
109IGF1R_20145208_ChIP-Seq_DFB_Human0.62552809
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.62509289
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.62005137
112CHD1_26751641_Chip-Seq_LNCaP_Human0.61340809
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.59184701
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.58968455
115ZNF274_21170338_ChIP-Seq_K562_Hela0.58262631
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.58178549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability5.10941599
2MP0003111_abnormal_nucleus_morphology5.00222437
3MP0003693_abnormal_embryo_hatching4.75055773
4MP0008057_abnormal_DNA_replication4.68892571
5MP0003077_abnormal_cell_cycle4.05097391
6MP0008058_abnormal_DNA_repair3.40160122
7MP0004957_abnormal_blastocyst_morpholog3.24949564
8MP0008877_abnormal_DNA_methylation3.06308553
9MP0010307_abnormal_tumor_latency2.80759076
10MP0002396_abnormal_hematopoietic_system2.78136928
11MP0008007_abnormal_cellular_replicative2.72070019
12MP0003121_genomic_imprinting2.44764612
13MP0009697_abnormal_copulation2.39571220
14MP0000569_abnormal_digit_pigmentation2.37177473
15MP0000350_abnormal_cell_proliferation2.25859741
16MP0008932_abnormal_embryonic_tissue2.18561096
17MP0001730_embryonic_growth_arrest2.15460236
18MP0003123_paternal_imprinting2.08660375
19MP0004808_abnormal_hematopoietic_stem1.99523350
20MP0003787_abnormal_imprinting1.93420769
21MP0001672_abnormal_embryogenesis/_devel1.92928349
22MP0005380_embryogenesis_phenotype1.92928349
23MP0005076_abnormal_cell_differentiation1.80452419
24MP0003984_embryonic_growth_retardation1.78408000
25MP0002088_abnormal_embryonic_growth/wei1.73429971
26MP0010352_gastrointestinal_tract_polyps1.68216047
27MP0003786_premature_aging1.65944130
28MP0001697_abnormal_embryo_size1.64037273
29MP0000490_abnormal_crypts_of1.61743350
30MP0002085_abnormal_embryonic_tissue1.48812663
31MP0001545_abnormal_hematopoietic_system1.48004896
32MP0005397_hematopoietic_system_phenotyp1.48004896
33MP0000313_abnormal_cell_death1.46661575
34MP0002080_prenatal_lethality1.46594448
35MP0002084_abnormal_developmental_patter1.46199969
36MP0002086_abnormal_extraembryonic_tissu1.42877791
37MP0004197_abnormal_fetal_growth/weight/1.38231759
38MP0003567_abnormal_fetal_cardiomyocyte1.36375394
39MP0002210_abnormal_sex_determination1.34264792
40MP0002160_abnormal_reproductive_system1.29936297
41MP0002019_abnormal_tumor_incidence1.26977948
42MP0003890_abnormal_embryonic-extraembry1.26730765
43MP0003718_maternal_effect1.25608124
44MP0003941_abnormal_skin_development1.20865520
45MP0000703_abnormal_thymus_morphology1.18913917
46MP0009278_abnormal_bone_marrow1.18296765
47MP0010234_abnormal_vibrissa_follicle1.17740296
48MP0002877_abnormal_melanocyte_morpholog1.14583492
49* MP0002398_abnormal_bone_marrow1.13513408
50MP0001929_abnormal_gametogenesis1.12758290
51MP0000015_abnormal_ear_pigmentation1.11849109
52MP0001145_abnormal_male_reproductive1.07851565
53MP0009703_decreased_birth_body1.04580948
54MP0009672_abnormal_birth_weight1.02231331
55MP0006035_abnormal_mitochondrial_morpho1.01866138
56MP0000383_abnormal_hair_follicle1.00559552
57MP0005257_abnormal_intraocular_pressure0.99414675
58MP0001529_abnormal_vocalization0.98041748
59MP0003937_abnormal_limbs/digits/tail_de0.97297812
60MP0000358_abnormal_cell_content/0.97175704
61MP0002722_abnormal_immune_system0.95471494
62MP0001661_extended_life_span0.95258354
63MP0003656_abnormal_erythrocyte_physiolo0.92388749
64MP0001293_anophthalmia0.92369461
65MP0000653_abnormal_sex_gland0.91489157
66MP0000733_abnormal_muscle_development0.90933065
67MP0000427_abnormal_hair_cycle0.89789655
68MP0005621_abnormal_cell_physiology0.88864813
69MP0000689_abnormal_spleen_morphology0.87572129
70MP0003943_abnormal_hepatobiliary_system0.86910854
71MP0000372_irregular_coat_pigmentation0.86712121
72MP0005384_cellular_phenotype0.85729446
73MP0001346_abnormal_lacrimal_gland0.83593321
74MP0002938_white_spotting0.83241811
75MP0009333_abnormal_splenocyte_physiolog0.83002486
76MP0004147_increased_porphyrin_level0.82817516
77MP0002102_abnormal_ear_morphology0.82103684
78MP0002095_abnormal_skin_pigmentation0.81735998
79MP0000428_abnormal_craniofacial_morphol0.81561118
80MP0003763_abnormal_thymus_physiology0.78259909
81MP0006072_abnormal_retinal_apoptosis0.76765913
82MP0001915_intracranial_hemorrhage0.76541181
83MP0003315_abnormal_perineum_morphology0.76295459
84MP0006292_abnormal_olfactory_placode0.76265526
85MP0005389_reproductive_system_phenotype0.76206933
86* MP0002429_abnormal_blood_cell0.74525201
87MP0003698_abnormal_male_reproductive0.74434923
88MP0001119_abnormal_female_reproductive0.73145474
89MP0003935_abnormal_craniofacial_develop0.72357905
90MP0008260_abnormal_autophagy0.72334975
91MP0005395_other_phenotype0.71386640
92MP0005083_abnormal_biliary_tract0.70428342
93MP0002075_abnormal_coat/hair_pigmentati0.69945742
94MP0008770_decreased_survivor_rate0.69805948
95MP0003806_abnormal_nucleotide_metabolis0.69748151
96MP0005174_abnormal_tail_pigmentation0.68316195
97MP0000432_abnormal_head_morphology0.68230372
98MP0000627_abnormal_mammary_gland0.66703246
99MP0002009_preneoplasia0.65918734
100* MP0000716_abnormal_immune_system0.65772552
101MP0002925_abnormal_cardiovascular_devel0.63922084
102MP0002006_tumorigenesis0.63771838
103MP0009053_abnormal_anal_canal0.61788651
104MP0000371_diluted_coat_color0.61100241
105MP0003861_abnormal_nervous_system0.60947710
106MP0003699_abnormal_female_reproductive0.60527726
107MP0003221_abnormal_cardiomyocyte_apopto0.60460936
108MP0002697_abnormal_eye_size0.59930022
109MP0002092_abnormal_eye_morphology0.59661361
110MP0003705_abnormal_hypodermis_morpholog0.59357040
111MP0002166_altered_tumor_susceptibility0.59146051
112MP0000266_abnormal_heart_morphology0.58606155
113MP0005075_abnormal_melanosome_morpholog0.58368191
114MP0002161_abnormal_fertility/fecundity0.57408366
115MP0008995_early_reproductive_senescence0.57207196
116MP0003936_abnormal_reproductive_system0.57202771
117MP0002111_abnormal_tail_morphology0.56970512
118* MP0001800_abnormal_humoral_immune0.56687525
119MP0003136_yellow_coat_color0.56566726
120MP0001286_abnormal_eye_development0.56167257
121MP0001186_pigmentation_phenotype0.56156634
122MP0004264_abnormal_extraembryonic_tissu0.55902970
123MP0004185_abnormal_adipocyte_glucose0.55462000
124MP0003950_abnormal_plasma_membrane0.54481347
125MP0004233_abnormal_muscle_weight0.54309328
126MP0010678_abnormal_skin_adnexa0.52949672
127MP0000647_abnormal_sebaceous_gland0.52325007
128MP0002970_abnormal_white_adipose0.51140460

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.44975133
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.36105886
3Birth length less than 3rd percentile (HP:0003561)4.37549557
4Abnormality of chromosome stability (HP:0003220)4.17220168
5Volvulus (HP:0002580)3.86683654
6Impulsivity (HP:0100710)3.86114465
7Ectopic kidney (HP:0000086)3.52987508
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.50103480
9Abnormality of the preputium (HP:0100587)3.46717086
10Meckel diverticulum (HP:0002245)3.43237386
11Abnormality of the ileum (HP:0001549)3.32525835
12Abnormality of the fingertips (HP:0001211)3.30608886
13Abnormality of the labia minora (HP:0012880)2.99717796
14Patellar aplasia (HP:0006443)2.97875851
15Myelodysplasia (HP:0002863)2.94632058
16Prominent nose (HP:0000448)2.90868526
17Small intestinal stenosis (HP:0012848)2.89722304
18Duodenal stenosis (HP:0100867)2.89722304
19Abnormality of the carotid arteries (HP:0005344)2.84056070
20Increased nuchal translucency (HP:0010880)2.74057589
21Aplasia/Hypoplasia of the patella (HP:0006498)2.73913223
22Sloping forehead (HP:0000340)2.61325490
23Long eyelashes (HP:0000527)2.55970854
24Ependymoma (HP:0002888)2.54802723
25Absent radius (HP:0003974)2.54233249
26Duplicated collecting system (HP:0000081)2.53463069
27Chronic otitis media (HP:0000389)2.50993436
28Breast hypoplasia (HP:0003187)2.50484236
29Short 4th metacarpal (HP:0010044)2.50266686
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50266686
31Prostate neoplasm (HP:0100787)2.50057419
32Cafe-au-lait spot (HP:0000957)2.44729581
33Medulloblastoma (HP:0002885)2.44714611
34Selective tooth agenesis (HP:0001592)2.44585739
35Clubbing of toes (HP:0100760)2.44163093
36Bone marrow hypocellularity (HP:0005528)2.41276619
37Aplasia involving forearm bones (HP:0009822)2.36449109
38Absent forearm bone (HP:0003953)2.36449109
39Aplasia/Hypoplasia of the earlobes (HP:0009906)2.32183193
40Abnormality of the duodenum (HP:0002246)2.31605880
41Abnormality of the renal collecting system (HP:0004742)2.30733122
42Proximal placement of thumb (HP:0009623)2.30162865
43Embryonal neoplasm (HP:0002898)2.29540813
44Oligodactyly (hands) (HP:0001180)2.29518344
45Facial hemangioma (HP:0000329)2.28423429
46Cortical dysplasia (HP:0002539)2.27082713
47Abnormality of DNA repair (HP:0003254)2.23610162
48Deviation of the thumb (HP:0009603)2.23264599
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21175508
50Reticulocytopenia (HP:0001896)2.20410697
51Short thumb (HP:0009778)2.19633695
52Neoplasm of the adrenal cortex (HP:0100641)2.14525243
53Nephroblastoma (Wilms tumor) (HP:0002667)2.14487200
54High pitched voice (HP:0001620)2.13832196
55Astrocytoma (HP:0009592)2.09528354
56Abnormality of the astrocytes (HP:0100707)2.09528354
57Pelvic girdle muscle weakness (HP:0003749)2.08695152
58Agnosia (HP:0010524)2.06637916
59Microtia (HP:0008551)2.05963994
60Glioma (HP:0009733)2.05379398
61Oligodactyly (HP:0012165)2.05158092
62Abnormality of the heme biosynthetic pathway (HP:0010472)2.04561526
63Acute myeloid leukemia (HP:0004808)2.02903411
64Abnormality of chromosome segregation (HP:0002916)2.02706918
65Deep philtrum (HP:0002002)2.02617432
66Neoplasm of the colon (HP:0100273)2.02377708
67Embryonal renal neoplasm (HP:0011794)1.99377352
68Abnormal number of incisors (HP:0011064)1.99151281
69Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98379615
70Tracheoesophageal fistula (HP:0002575)1.97398208
71Sandal gap (HP:0001852)1.95052834
72Microvesicular hepatic steatosis (HP:0001414)1.91756843
73Abnormality of cochlea (HP:0000375)1.91415200
74Rhabdomyosarcoma (HP:0002859)1.88567680
75Entropion (HP:0000621)1.86885449
76Absent thumb (HP:0009777)1.86409524
77Acute lymphatic leukemia (HP:0006721)1.86136534
78Truncal obesity (HP:0001956)1.84111680
79Atresia of the external auditory canal (HP:0000413)1.83608968
80Abnormality of the pons (HP:0007361)1.83565521
81Astigmatism (HP:0000483)1.82770861
82Duplication of thumb phalanx (HP:0009942)1.80483140
83Oral leukoplakia (HP:0002745)1.80459998
84Premature graying of hair (HP:0002216)1.80309710
8511 pairs of ribs (HP:0000878)1.79807270
86Poikiloderma (HP:0001029)1.79645654
87Cutis marmorata (HP:0000965)1.79592101
88Overlapping toe (HP:0001845)1.79572218
89Triphalangeal thumb (HP:0001199)1.79499846
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.79075770
91Hypoplasia of the pons (HP:0012110)1.78180933
92Sparse lateral eyebrow (HP:0005338)1.77068848
93Lymphoma (HP:0002665)1.77018372
94Arteriovenous malformation (HP:0100026)1.76984463
95Pancreatic islet-cell hyperplasia (HP:0004510)1.75336411
96Urethral obstruction (HP:0000796)1.74168116
97Neoplasm of the pancreas (HP:0002894)1.73541735
98Obsessive-compulsive behavior (HP:0000722)1.73050137
99Horseshoe kidney (HP:0000085)1.72838384
100High anterior hairline (HP:0009890)1.72618101
101Skull defect (HP:0001362)1.70516238
102Squamous cell carcinoma (HP:0002860)1.70100585
103Poikilocytosis (HP:0004447)1.70002571
104Abnormality of the hip-girdle musculature (HP:0001445)1.68175914
105Abnormality of the musculature of the pelvis (HP:0001469)1.68175914
106Cellular immunodeficiency (HP:0005374)1.67992177
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67794851
108Multiple enchondromatosis (HP:0005701)1.66881903
109Heterotopia (HP:0002282)1.66346604
110Leukopenia (HP:0001882)1.66078528
111Anal stenosis (HP:0002025)1.64576237
112Short middle phalanx of the 5th finger (HP:0004220)1.64203986
113Carpal bone hypoplasia (HP:0001498)1.63901323
114Choanal atresia (HP:0000453)1.62776977
115Colon cancer (HP:0003003)1.61628787
116Abnormality of the columella (HP:0009929)1.60197044
117Neoplasm of striated muscle (HP:0009728)1.60054719
118Small hand (HP:0200055)1.59334172
119Abnormal lung lobation (HP:0002101)1.58839931
120Ureteral duplication (HP:0000073)1.58722625
121Oligohydramnios (HP:0001562)1.58386746
122Missing ribs (HP:0000921)1.55000407
123Hyperalaninemia (HP:0003348)1.54403446
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.54403446
125Abnormality of alanine metabolism (HP:0010916)1.54403446
126Ovarian neoplasm (HP:0100615)1.53089962
127Abnormality of pyrimidine metabolism (HP:0004353)1.49965835
128Progressive external ophthalmoplegia (HP:0000590)1.49728137
129Intrauterine growth retardation (HP:0001511)1.48436169
130Facial asymmetry (HP:0000324)1.47189431
131Recurrent urinary tract infections (HP:0000010)1.45861556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.37642479
2NEK24.17837827
3CDK123.48007799
4BUB13.18947140
5WEE13.18751955
6NEK12.85760865
7SRPK12.84897309
8PLK42.62885335
9BRD42.53959096
10MKNK22.48752248
11ACVR1B2.45540029
12TTK2.37716076
13MKNK12.19806990
14MAP3K132.18777373
15ATR2.07318717
16TAF12.06166348
17AURKB2.04515688
18PLK12.04404649
19CHEK22.01638436
20ZAK2.00407661
21PBK1.93830955
22EIF2AK11.90679550
23BRSK21.81128773
24VRK21.78326907
25TLK11.77505317
26CDK41.67615487
27PLK31.62773310
28CHEK11.62511516
29STK41.56270979
30TSSK61.51805762
31CCNB11.45482277
32BMPR1B1.39831005
33EEF2K1.37336849
34SMG11.36843134
35ATM1.36562297
36CDK71.36247980
37STK31.30206654
38MELK1.18099818
39LATS11.18009831
40DYRK31.14410641
41VRK11.13956744
42BRSK11.12480268
43RPS6KA41.11788794
44CDK61.10923664
45MAP3K81.06111829
46CDK21.06087622
47EIF2AK21.04164504
48FRK1.01112503
49BRAF1.00672682
50MAP3K101.00393705
51MST40.97252197
52PIM10.95712636
53STK100.95244379
54CDK10.90400243
55PASK0.89628364
56CDK80.88634581
57RPS6KB20.80779233
58AURKA0.79347216
59EIF2AK30.79319220
60CDK90.79034431
61TTN0.78542844
62CAMK1D0.73900327
63MTOR0.73162029
64MAP4K10.71543039
65NME20.70776693
66SCYL20.70186690
67NUAK10.68394174
68MST1R0.67609271
69MAP3K90.66226490
70CLK10.61734579
71YES10.61038787
72ALK0.59624406
73PRKDC0.58321878
74MARK30.55927666
75PNCK0.55858411
76RPS6KA50.55510319
77TRIM280.54300237
78MAPK140.49186089
79MAP3K140.47615948
80ERBB40.47472290
81STK160.47237799
82CDK30.47101119
83CSNK2A20.44802721
84PDK20.44564244
85CSNK1D0.43403297
86MAPKAPK50.43200292
87TRPM70.42448991
88TGFBR10.42096694
89NME10.41588481
90AKT20.41387556
91MAP2K30.40987989
92MET0.37429619
93GSK3B0.36954809
94AKT10.36932416
95AKT30.36343969
96STK38L0.35917224
97CSNK2A10.35907431
98STK390.35211071
99CAMK1G0.33825611
100CSNK1E0.33236852
101WNK40.32629445
102PKN20.32112484
103TXK0.28689616
104CHUK0.28604413
105RPS6KB10.28272535
106SIK20.27713427
107TAOK20.26562718
108CSNK1G10.26317751
109MAPK100.26011248
110JAK30.25894970
111MAPK10.24940569
112NEK90.24649683
113PAK40.24640654
114PRKCI0.23123260
115MAP3K50.22472730
116RAF10.22320579
117SGK20.21949810
118CSF1R0.21355214
119PAK10.19840290
120MAPK80.19569685
121BMPR20.18772681
122PLK20.18684310
123CDK180.18440479
124CSNK1A1L0.18408932
125FGFR10.17717571
126MAPK110.16379290
127TYK20.15926128

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47447904
2Mismatch repair_Homo sapiens_hsa034303.60923444
3Cell cycle_Homo sapiens_hsa041103.39514162
4Fanconi anemia pathway_Homo sapiens_hsa034603.17210541
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14498286
6Homologous recombination_Homo sapiens_hsa034403.05984738
7RNA transport_Homo sapiens_hsa030132.99381427
8Spliceosome_Homo sapiens_hsa030402.86991796
9Base excision repair_Homo sapiens_hsa034102.80557375
10Non-homologous end-joining_Homo sapiens_hsa034502.41673226
11Nucleotide excision repair_Homo sapiens_hsa034202.39576555
12One carbon pool by folate_Homo sapiens_hsa006702.38756028
13Systemic lupus erythematosus_Homo sapiens_hsa053222.25535998
14RNA polymerase_Homo sapiens_hsa030202.18449620
15mRNA surveillance pathway_Homo sapiens_hsa030152.14068021
16p53 signaling pathway_Homo sapiens_hsa041151.92147356
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90629895
18Basal transcription factors_Homo sapiens_hsa030221.88682680
19Pyrimidine metabolism_Homo sapiens_hsa002401.75882157
20RNA degradation_Homo sapiens_hsa030181.75819652
21Viral carcinogenesis_Homo sapiens_hsa052031.44016224
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40849584
23Vitamin B6 metabolism_Homo sapiens_hsa007501.39507180
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37171348
25Oocyte meiosis_Homo sapiens_hsa041141.32371417
26Herpes simplex infection_Homo sapiens_hsa051681.31106746
27MicroRNAs in cancer_Homo sapiens_hsa052061.28481556
28Epstein-Barr virus infection_Homo sapiens_hsa051691.25155165
29Small cell lung cancer_Homo sapiens_hsa052221.11298123
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05905679
31HTLV-I infection_Homo sapiens_hsa051661.05405083
32Proteasome_Homo sapiens_hsa030501.04069429
33Alcoholism_Homo sapiens_hsa050341.01465051
34Purine metabolism_Homo sapiens_hsa002301.01461691
35Lysine degradation_Homo sapiens_hsa003100.98219830
36NF-kappa B signaling pathway_Homo sapiens_hsa040640.94678263
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93905600
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87657736
39Chronic myeloid leukemia_Homo sapiens_hsa052200.87631437
40Biosynthesis of amino acids_Homo sapiens_hsa012300.85365031
41Measles_Homo sapiens_hsa051620.84060920
42mTOR signaling pathway_Homo sapiens_hsa041500.78456536
43Pyruvate metabolism_Homo sapiens_hsa006200.78418139
44Antigen processing and presentation_Homo sapiens_hsa046120.77979993
45Hepatitis B_Homo sapiens_hsa051610.76434602
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76339790
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73660326
48Primary immunodeficiency_Homo sapiens_hsa053400.71382021
49Protein export_Homo sapiens_hsa030600.70169977
50Ribosome_Homo sapiens_hsa030100.70097178
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69139471
52Influenza A_Homo sapiens_hsa051640.67256767
53Propanoate metabolism_Homo sapiens_hsa006400.66769022
54Apoptosis_Homo sapiens_hsa042100.65808019
55Hematopoietic cell lineage_Homo sapiens_hsa046400.63704552
56Colorectal cancer_Homo sapiens_hsa052100.63144329
57N-Glycan biosynthesis_Homo sapiens_hsa005100.62396222
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60942622
59Prostate cancer_Homo sapiens_hsa052150.60123061
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59332150
61Non-small cell lung cancer_Homo sapiens_hsa052230.58331133
62FoxO signaling pathway_Homo sapiens_hsa040680.56725103
63Viral myocarditis_Homo sapiens_hsa054160.56622150
64Pancreatic cancer_Homo sapiens_hsa052120.56518577
65HIF-1 signaling pathway_Homo sapiens_hsa040660.54461371
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53330716
67B cell receptor signaling pathway_Homo sapiens_hsa046620.52513540
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.52095417
69Steroid biosynthesis_Homo sapiens_hsa001000.51664899
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50898656
71Adherens junction_Homo sapiens_hsa045200.50861391
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50656459
73Carbon metabolism_Homo sapiens_hsa012000.49953120
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49566155
75TGF-beta signaling pathway_Homo sapiens_hsa043500.49276076
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48861179
77Basal cell carcinoma_Homo sapiens_hsa052170.48048776
78Fatty acid metabolism_Homo sapiens_hsa012120.47553768
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47128052
80Pentose phosphate pathway_Homo sapiens_hsa000300.45093910
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43774319
82Legionellosis_Homo sapiens_hsa051340.43143711
83Thyroid cancer_Homo sapiens_hsa052160.43011170
84Notch signaling pathway_Homo sapiens_hsa043300.42635102
85Pathways in cancer_Homo sapiens_hsa052000.41701945
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40333898
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38935777
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38706845
89T cell receptor signaling pathway_Homo sapiens_hsa046600.38075517
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37630422
91Endometrial cancer_Homo sapiens_hsa052130.37312799
92Melanoma_Homo sapiens_hsa052180.37029854
93Hippo signaling pathway_Homo sapiens_hsa043900.36282296
94Selenocompound metabolism_Homo sapiens_hsa004500.35112529
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34810579
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34780432
97Leishmaniasis_Homo sapiens_hsa051400.34409754
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34168422
99Glutathione metabolism_Homo sapiens_hsa004800.33909125
100Folate biosynthesis_Homo sapiens_hsa007900.32288061
101Acute myeloid leukemia_Homo sapiens_hsa052210.31977552
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.31443784
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30848769
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.30541742
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30531498
106Proteoglycans in cancer_Homo sapiens_hsa052050.30327942
107Fatty acid elongation_Homo sapiens_hsa000620.30029736
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.30017254
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28703403
110Inositol phosphate metabolism_Homo sapiens_hsa005620.28462145
111Huntingtons disease_Homo sapiens_hsa050160.28370089
112Glioma_Homo sapiens_hsa052140.27529890
113Toxoplasmosis_Homo sapiens_hsa051450.27479794
114Bladder cancer_Homo sapiens_hsa052190.26673377
115Metabolic pathways_Homo sapiens_hsa011000.26579631
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26565978
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26327832
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26087123
119Shigellosis_Homo sapiens_hsa051310.25883335
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25271950
121Wnt signaling pathway_Homo sapiens_hsa043100.23895306
122Osteoclast differentiation_Homo sapiens_hsa043800.23675965
123Hedgehog signaling pathway_Homo sapiens_hsa043400.23593111
124Fatty acid biosynthesis_Homo sapiens_hsa000610.23398852
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23351546
126Circadian rhythm_Homo sapiens_hsa047100.23140092
127TNF signaling pathway_Homo sapiens_hsa046680.22211006
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.20863691
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.18862399
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.16060953
131Nitrogen metabolism_Homo sapiens_hsa009100.15855589
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15784471
133Caffeine metabolism_Homo sapiens_hsa002320.11359832
134Butanoate metabolism_Homo sapiens_hsa006500.11110527
135Fatty acid degradation_Homo sapiens_hsa000710.09209887
136Sulfur relay system_Homo sapiens_hsa041220.05587626
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04513434

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