POLR1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.17298847
2nuclear pore organization (GO:0006999)6.15604619
3DNA unwinding involved in DNA replication (GO:0006268)4.98157838
4protein localization to kinetochore (GO:0034501)4.93426740
5IMP biosynthetic process (GO:0006188)4.78447808
6mitotic nuclear envelope disassembly (GO:0007077)4.73283438
7folic acid-containing compound biosynthetic process (GO:0009396)4.65529108
8pore complex assembly (GO:0046931)4.61157721
9nuclear envelope disassembly (GO:0051081)4.42068591
10membrane disassembly (GO:0030397)4.42068591
11pre-miRNA processing (GO:0031054)4.34063338
12IMP metabolic process (GO:0046040)4.21051982
13regulation of translational fidelity (GO:0006450)4.17028690
14protein localization to chromosome, centromeric region (GO:0071459)4.08679339
15heterochromatin organization (GO:0070828)4.08266977
16DNA replication-dependent nucleosome assembly (GO:0006335)4.08146669
17DNA replication-dependent nucleosome organization (GO:0034723)4.08146669
18regulation of posttranscriptional gene silencing (GO:0060147)3.97026260
19regulation of gene silencing by miRNA (GO:0060964)3.97026260
20regulation of gene silencing by RNA (GO:0060966)3.97026260
21regulation of spindle organization (GO:0090224)3.95601073
22DNA duplex unwinding (GO:0032508)3.94226967
23nucleobase biosynthetic process (GO:0046112)3.92488506
24DNA geometric change (GO:0032392)3.92065473
25DNA replication initiation (GO:0006270)3.88923444
26regulation of RNA export from nucleus (GO:0046831)3.88871045
27mitotic chromosome condensation (GO:0007076)3.85890316
28mitotic sister chromatid cohesion (GO:0007064)3.77123693
29regulation of mitotic spindle organization (GO:0060236)3.76226692
30mitotic sister chromatid segregation (GO:0000070)3.70462739
31sister chromatid segregation (GO:0000819)3.70043158
32negative regulation of histone methylation (GO:0031061)3.69367967
33regulation of histone H3-K9 methylation (GO:0051570)3.68995332
34mitotic metaphase plate congression (GO:0007080)3.59788407
35regulation of translational termination (GO:0006449)3.58773308
36nuclear envelope organization (GO:0006998)3.52775333
37chromatin assembly (GO:0031497)3.52565176
38ribosome assembly (GO:0042255)3.47587516
39formation of translation preinitiation complex (GO:0001731)3.47229435
40positive regulation of DNA-dependent DNA replication (GO:2000105)3.46969507
41dosage compensation (GO:0007549)3.43599650
42DNA strand elongation involved in DNA replication (GO:0006271)3.42942560
43protein complex localization (GO:0031503)3.42094360
44positive regulation of chromosome segregation (GO:0051984)3.37357771
45purine nucleobase biosynthetic process (GO:0009113)3.36450657
46DNA replication checkpoint (GO:0000076)3.32152565
47cellular protein complex localization (GO:0034629)3.30315306
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29275371
49spliceosomal tri-snRNP complex assembly (GO:0000244)3.28147869
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25853906
51DNA strand elongation (GO:0022616)3.24428275
52ribosome biogenesis (GO:0042254)3.23205194
53paraxial mesoderm development (GO:0048339)3.22751657
54metaphase plate congression (GO:0051310)3.16680607
55DNA conformation change (GO:0071103)3.14244508
56maturation of SSU-rRNA (GO:0030490)3.11067980
57RNA stabilization (GO:0043489)3.07929440
58mRNA stabilization (GO:0048255)3.07929440
59positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.07291354
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.06917508
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06917508
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05990691
63non-recombinational repair (GO:0000726)3.05570744
64double-strand break repair via nonhomologous end joining (GO:0006303)3.05570744
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05169161
66histone H2A monoubiquitination (GO:0035518)3.03765024
67chromatin assembly or disassembly (GO:0006333)3.03408408
68protein localization to chromosome (GO:0034502)3.01990107
69mRNA transport (GO:0051028)3.00690280
70regulation of sister chromatid cohesion (GO:0007063)2.98887977
71regulation of nucleobase-containing compound transport (GO:0032239)2.97095793
72glucocorticoid receptor signaling pathway (GO:0042921)2.96523711
73hemidesmosome assembly (GO:0031581)2.95586665
74protein export from nucleus (GO:0006611)2.95222530
75regulation of centrosome cycle (GO:0046605)2.94235954
76kinetochore organization (GO:0051383)2.93530428
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.92346696
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92346696
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92346696
80COPI coating of Golgi vesicle (GO:0048205)2.92242578
81Golgi transport vesicle coating (GO:0048200)2.92242578
82DNA packaging (GO:0006323)2.91258213
83meiotic chromosome segregation (GO:0045132)2.90256387
84peptidyl-lysine dimethylation (GO:0018027)2.89957762
85proline biosynthetic process (GO:0006561)2.89122097
86negative regulation of DNA repair (GO:0045738)2.88765545
87attachment of spindle microtubules to kinetochore (GO:0008608)2.87201386
88positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.86991879
89positive regulation of cell cycle G2/M phase transition (GO:1902751)2.86991879
90telomere maintenance via semi-conservative replication (GO:0032201)2.86294782
91regulation of chromosome segregation (GO:0051983)2.85969458
92NLS-bearing protein import into nucleus (GO:0006607)2.84093785
93regulation of mammary gland epithelial cell proliferation (GO:0033599)2.82857172
94chaperone-mediated protein complex assembly (GO:0051131)2.82702764
95positive regulation of SMAD protein import into nucleus (GO:0060391)2.82088044
96regulation of gene silencing (GO:0060968)2.81732651
97negative regulation of mRNA metabolic process (GO:1903312)2.80914845
98DNA topological change (GO:0006265)2.80632524
99regulation of histone H3-K27 methylation (GO:0061085)2.80365965
100snRNA processing (GO:0016180)2.80066062
101negative regulation of chromosome segregation (GO:0051985)2.79729570
102regulation of centrosome duplication (GO:0010824)2.78740156
103snRNA metabolic process (GO:0016073)2.78591218
104nucleosome disassembly (GO:0006337)2.76631198
105protein-DNA complex disassembly (GO:0032986)2.76631198
106RNA transport (GO:0050658)2.76525090
107establishment of RNA localization (GO:0051236)2.76525090
108nucleic acid transport (GO:0050657)2.76525090
109spindle checkpoint (GO:0031577)2.76272957
110mitotic G1 DNA damage checkpoint (GO:0031571)2.76007504
111mitotic recombination (GO:0006312)2.75045562
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74895897
113DNA synthesis involved in DNA repair (GO:0000731)2.74680257
114chromosome condensation (GO:0030261)2.74235634
115spindle assembly checkpoint (GO:0071173)2.73878161
116adherens junction assembly (GO:0034333)2.73419562
117peptidyl-arginine omega-N-methylation (GO:0035247)2.71460666
118establishment of chromosome localization (GO:0051303)2.71399174
119tetrahydrofolate metabolic process (GO:0046653)2.71206427
120ribonucleoprotein complex biogenesis (GO:0022613)2.70989890
121determination of adult lifespan (GO:0008340)2.70836347
122DNA replication-independent nucleosome assembly (GO:0006336)2.70575356
123DNA replication-independent nucleosome organization (GO:0034724)2.70575356
124negative regulation of mRNA processing (GO:0050686)2.70555951
125rRNA transcription (GO:0009303)2.70414364
126stress granule assembly (GO:0034063)2.70132906
127regulation of centriole replication (GO:0046599)2.69996467
128mitotic spindle checkpoint (GO:0071174)2.69745922
129cell-substrate adherens junction assembly (GO:0007045)2.69353865
130focal adhesion assembly (GO:0048041)2.69353865
131cell-substrate junction assembly (GO:0007044)2.63449610
132activation of Rac GTPase activity (GO:0032863)2.59309725
133positive regulation of cell cycle checkpoint (GO:1901978)2.56651502
134histone phosphorylation (GO:0016572)2.56619538
135regulation of NFAT protein import into nucleus (GO:0051532)2.56051788
136regulation of DNA-dependent DNA replication (GO:0090329)2.54530553
137regulation of hippo signaling (GO:0035330)2.53734733
138regulation of nuclear cell cycle DNA replication (GO:0033262)2.52875118
139regulation of DNA damage checkpoint (GO:2000001)2.51662650
140folic acid metabolic process (GO:0046655)2.48278421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.61921810
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.88150635
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.80351578
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71900084
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.28959301
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99410632
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96461342
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.95186364
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92259572
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.53476365
11MYC_22102868_ChIP-Seq_BL_Human2.52848982
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48986898
13AR_21909140_ChIP-Seq_LNCAP_Human2.32905424
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.20927317
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13954850
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13082100
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05081050
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99390228
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96725601
20* XRN2_22483619_ChIP-Seq_HELA_Human1.90061590
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83495023
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82678762
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79913767
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.76078315
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75469212
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.73060700
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.70254544
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66524884
29CIITA_25753668_ChIP-Seq_RAJI_Human1.65165179
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64772725
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64357593
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58107844
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52977613
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52493072
35KDM5A_27292631_Chip-Seq_BREAST_Human1.52250887
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46230671
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.45895939
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45202338
39* FOXP3_21729870_ChIP-Seq_TREG_Human1.41922548
40VDR_23849224_ChIP-Seq_CD4+_Human1.39354853
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39188468
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38349444
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37985769
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37014363
45* TTF2_22483619_ChIP-Seq_HELA_Human1.35625774
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35569741
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35041662
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33707596
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33346456
50PKCTHETA_26484144_Chip-Seq_BREAST_Human1.31886566
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31311473
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30623509
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30623509
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30623509
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29413676
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28952596
57* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28240831
58VDR_21846776_ChIP-Seq_THP-1_Human1.27022621
59GABP_19822575_ChIP-Seq_HepG2_Human1.26600317
60DCP1A_22483619_ChIP-Seq_HELA_Human1.25171484
61* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23920719
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23175227
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21687149
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21501436
65* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21198936
66RACK7_27058665_Chip-Seq_MCF-7_Human1.20555311
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20533483
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20443854
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20397130
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20161164
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19150075
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18783453
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18553989
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18054051
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16838955
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16178897
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.15636388
78TP53_22127205_ChIP-Seq_IMR90_Human1.15440771
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.14145551
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.13870892
81TFEB_21752829_ChIP-Seq_HELA_Human1.13673703
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.12637137
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11337732
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11121324
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10981337
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10702201
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08414281
88ELK1_19687146_ChIP-ChIP_HELA_Human1.07491684
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07248919
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06984405
91CLOCK_20551151_ChIP-Seq_293T_Human1.06570879
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06238404
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05746848
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05540941
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05079137
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03784923
97TCF7_22412390_ChIP-Seq_EML_Mouse1.02072401
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01586994
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00898446
100ZNF263_19887448_ChIP-Seq_K562_Human1.00613318
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00561382
102* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99922387
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99737579
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99434306
105GATA1_22025678_ChIP-Seq_K562_Human0.98566713
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97446810
107FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97433733
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97274539
109CHD1_26751641_Chip-Seq_LNCaP_Human0.96952898
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95326729
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94711188
112* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94351031
113ATF3_27146783_Chip-Seq_COLON_Human0.93882019
114SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93480728
115GATA6_25053715_ChIP-Seq_YYC3_Human0.92893338
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91244584
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91160549
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90517119
119ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89477612
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89454730
121NCOR1_26117541_ChIP-Seq_K562_Human0.88542220
122ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87880216
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87418775
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87353517
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87299369
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87261065
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87261065
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.86629908
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86280144
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85701518
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85631547
132* NOTCH1_21737748_ChIP-Seq_TLL_Human0.85430376
133KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85324390
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85235062
135NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85089246
136FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84828239
137HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83660591
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83509067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.86725322
2MP0010094_abnormal_chromosome_stability3.72228095
3MP0003111_abnormal_nucleus_morphology3.71380967
4MP0008057_abnormal_DNA_replication3.52156558
5MP0004957_abnormal_blastocyst_morpholog3.49792130
6MP0003077_abnormal_cell_cycle3.24926804
7MP0010352_gastrointestinal_tract_polyps3.18947572
8MP0003705_abnormal_hypodermis_morpholog2.69245597
9MP0001730_embryonic_growth_arrest2.54437378
10MP0003123_paternal_imprinting2.46903811
11MP0010307_abnormal_tumor_latency2.39679817
12MP0005076_abnormal_cell_differentiation2.34643028
13MP0000350_abnormal_cell_proliferation2.27739140
14MP0008007_abnormal_cellular_replicative2.15498783
15MP0001672_abnormal_embryogenesis/_devel2.14483206
16MP0005380_embryogenesis_phenotype2.14483206
17MP0008058_abnormal_DNA_repair2.13425706
18MP0002396_abnormal_hematopoietic_system2.12064022
19MP0003984_embryonic_growth_retardation2.01925823
20MP0002088_abnormal_embryonic_growth/wei1.98547075
21MP0004197_abnormal_fetal_growth/weight/1.98345460
22MP0008932_abnormal_embryonic_tissue1.91873294
23MP0002084_abnormal_developmental_patter1.90072088
24MP0001697_abnormal_embryo_size1.87672146
25MP0001661_extended_life_span1.83030764
26MP0002086_abnormal_extraembryonic_tissu1.81390530
27MP0002085_abnormal_embryonic_tissue1.79641592
28MP0008877_abnormal_DNA_methylation1.69233883
29MP0005409_darkened_coat_color1.66757072
30MP0002080_prenatal_lethality1.66123645
31MP0003567_abnormal_fetal_cardiomyocyte1.64541419
32MP0004808_abnormal_hematopoietic_stem1.61754217
33MP0005451_abnormal_body_composition1.60926151
34MP0003566_abnormal_cell_adhesion1.59272340
35MP0000537_abnormal_urethra_morphology1.59096123
36MP0005257_abnormal_intraocular_pressure1.57638681
37MP0001348_abnormal_lacrimal_gland1.54721693
38MP0003890_abnormal_embryonic-extraembry1.51571398
39MP0002009_preneoplasia1.50740839
40MP0004272_abnormal_basement_membrane1.42832917
41MP0009053_abnormal_anal_canal1.39089688
42MP0003121_genomic_imprinting1.38283136
43MP0001293_anophthalmia1.37694613
44MP0003786_premature_aging1.35337524
45MP0000733_abnormal_muscle_development1.34059907
46MP0002089_abnormal_postnatal_growth/wei1.32174570
47MP0010030_abnormal_orbit_morphology1.26855439
48MP0009278_abnormal_bone_marrow1.24321414
49MP0009672_abnormal_birth_weight1.22602200
50MP0003119_abnormal_digestive_system1.21838230
51MP0002060_abnormal_skin_morphology1.20944822
52MP0005023_abnormal_wound_healing1.20446498
53MP0000313_abnormal_cell_death1.19820574
54MP0004233_abnormal_muscle_weight1.16944046
55MP0000579_abnormal_nail_morphology1.16313267
56MP0002019_abnormal_tumor_incidence1.14866337
57MP0000490_abnormal_crypts_of1.12137444
58MP0009703_decreased_birth_body1.12076919
59MP0003942_abnormal_urinary_system1.11543528
60MP0001915_intracranial_hemorrhage1.11481073
61MP0001849_ear_inflammation1.10530494
62MP0000003_abnormal_adipose_tissue1.09886871
63MP0000428_abnormal_craniofacial_morphol1.09061463
64MP0005623_abnormal_meninges_morphology1.07271173
65MP0010630_abnormal_cardiac_muscle1.02632396
66MP0003385_abnormal_body_wall1.02391553
67MP0000566_synostosis1.00358757
68MP0000462_abnormal_digestive_system0.99266535
69MP0002092_abnormal_eye_morphology0.99257249
70MP0003806_abnormal_nucleotide_metabolis0.98853455
71MP0000750_abnormal_muscle_regeneration0.97282305
72MP0009697_abnormal_copulation0.97145469
73MP0002925_abnormal_cardiovascular_devel0.97022429
74MP0000534_abnormal_ureter_morphology0.96707656
75MP0003115_abnormal_respiratory_system0.95827979
76MP0002111_abnormal_tail_morphology0.95342069
77MP0004084_abnormal_cardiac_muscle0.95097780
78MP0002877_abnormal_melanocyte_morpholog0.94892646
79MP0003937_abnormal_limbs/digits/tail_de0.93838995
80MP0003943_abnormal_hepatobiliary_system0.90893061
81MP0001545_abnormal_hematopoietic_system0.90841283
82MP0005397_hematopoietic_system_phenotyp0.90841283
83MP0002269_muscular_atrophy0.90183843
84MP0002697_abnormal_eye_size0.90144497
85MP0000703_abnormal_thymus_morphology0.89868696
86MP0000467_abnormal_esophagus_morphology0.89845274
87MP0004185_abnormal_adipocyte_glucose0.88455883
88MP0000432_abnormal_head_morphology0.87413278
89MP0000266_abnormal_heart_morphology0.86573358
90MP0003935_abnormal_craniofacial_develop0.85683031
91MP0005501_abnormal_skin_physiology0.85323682
92MP0004264_abnormal_extraembryonic_tissu0.84940834
93MP0005621_abnormal_cell_physiology0.84258723
94MP0002210_abnormal_sex_determination0.83197379
95MP0000762_abnormal_tongue_morphology0.83036872
96MP0008438_abnormal_cutaneous_collagen0.81118998
97MP0003221_abnormal_cardiomyocyte_apopto0.80160737
98MP0001216_abnormal_epidermal_layer0.79808635
99MP0001873_stomach_inflammation0.79726158
100MP0003755_abnormal_palate_morphology0.79472208
101MP0005384_cellular_phenotype0.79387616
102MP0003763_abnormal_thymus_physiology0.79004995
103MP0005197_abnormal_uvea_morphology0.78845026
104MP0000377_abnormal_hair_follicle0.78828739
105MP0010234_abnormal_vibrissa_follicle0.78235236
106MP0001145_abnormal_male_reproductive0.77593775
107MP0004858_abnormal_nervous_system0.77551395
108MP0003718_maternal_effect0.77096340
109MP0004087_abnormal_muscle_fiber0.76732305
110MP0002796_impaired_skin_barrier0.76723844
111MP0001346_abnormal_lacrimal_gland0.76702605
112MP0003091_abnormal_cell_migration0.76076692
113MP0008770_decreased_survivor_rate0.75107257
114MP0002234_abnormal_pharynx_morphology0.74165779
115MP0003453_abnormal_keratinocyte_physiol0.73573449
116MP0003941_abnormal_skin_development0.71535447
117MP0003861_abnormal_nervous_system0.71478286
118MP0000759_abnormal_skeletal_muscle0.70494986
119MP0000627_abnormal_mammary_gland0.69599147
120MP0002970_abnormal_white_adipose0.69338222
121MP0008961_abnormal_basal_metabolism0.69147935
122MP0009333_abnormal_splenocyte_physiolog0.69134898
123MP0001286_abnormal_eye_development0.66203576
124MP0000358_abnormal_cell_content/0.65869661
125MP0003279_aneurysm0.65620026
126MP0003300_gastrointestinal_ulcer0.65163251
127MP0002653_abnormal_ependyma_morphology0.65142484
128MP0000371_diluted_coat_color0.63911916
129MP0002722_abnormal_immune_system0.62247468
130MP0005666_abnormal_adipose_tissue0.62222371
131MP0004133_heterotaxia0.62001124
132MP0002398_abnormal_bone_marrow0.61455276
133MP0000477_abnormal_intestine_morphology0.60683976
134MP0000858_altered_metastatic_potential0.59537421
135MP0003315_abnormal_perineum_morphology0.59336856
136MP0001929_abnormal_gametogenesis0.58960468
137MP0001784_abnormal_fluid_regulation0.58517852

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.02560659
2Selective tooth agenesis (HP:0001592)3.65492582
3Astrocytoma (HP:0009592)3.15585806
4Abnormality of the astrocytes (HP:0100707)3.15585806
5Medulloblastoma (HP:0002885)3.01211619
6Deviation of the thumb (HP:0009603)2.90612538
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.85671532
8Short 4th metacarpal (HP:0010044)2.85671532
9Dysmetric saccades (HP:0000641)2.85157937
10Proximal placement of thumb (HP:0009623)2.82351663
11Progressive muscle weakness (HP:0003323)2.76631918
12Birth length less than 3rd percentile (HP:0003561)2.73390426
13Rhabdomyosarcoma (HP:0002859)2.71992709
14Abnormality of the labia minora (HP:0012880)2.71154087
15Impulsivity (HP:0100710)2.69932239
16Insomnia (HP:0100785)2.68944066
17Colon cancer (HP:0003003)2.66373299
18Elfin facies (HP:0004428)2.61630825
19Asymmetry of the thorax (HP:0001555)2.60288478
20Glioma (HP:0009733)2.59140989
21Chromsome breakage (HP:0040012)2.58052371
22Broad face (HP:0000283)2.53725016
23Renovascular hypertension (HP:0100817)2.51609659
24Increased nuchal translucency (HP:0010880)2.50258597
25Prominent nose (HP:0000448)2.45302672
26Neoplasm of striated muscle (HP:0009728)2.43147808
27Overriding aorta (HP:0002623)2.42809508
28Neoplasm of the oral cavity (HP:0100649)2.38488994
29Ectopic kidney (HP:0000086)2.36601041
30Ankle contracture (HP:0006466)2.34449247
31Volvulus (HP:0002580)2.33971821
32Long eyelashes (HP:0000527)2.33608025
33Biliary tract neoplasm (HP:0100574)2.33459565
34Degeneration of anterior horn cells (HP:0002398)2.31092391
35Abnormality of the anterior horn cell (HP:0006802)2.31092391
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30923629
37Basal cell carcinoma (HP:0002671)2.30456702
38Deep philtrum (HP:0002002)2.30142102
39Abnormal number of incisors (HP:0011064)2.28747227
40Missing ribs (HP:0000921)2.28381059
41Short humerus (HP:0005792)2.25927825
42High pitched voice (HP:0001620)2.25463599
43Aplasia/hypoplasia of the humerus (HP:0006507)2.23823350
44Abnormality of the calcaneus (HP:0008364)2.22575847
45Urethral obstruction (HP:0000796)2.20399821
46Abnormality of chromosome stability (HP:0003220)2.19732861
47Breast hypoplasia (HP:0003187)2.19322292
48Ankyloglossia (HP:0010296)2.18891280
49Abnormality of the 4th metacarpal (HP:0010012)2.16809967
50Patellar aplasia (HP:0006443)2.14961081
51Short nail (HP:0001799)2.14767676
52Septate vagina (HP:0001153)2.14546566
53Abnormality of the fingertips (HP:0001211)2.12207866
54Protrusio acetabuli (HP:0003179)2.08809145
55Cafe-au-lait spot (HP:0000957)2.06187038
56High anterior hairline (HP:0009890)2.05688003
57Flat cornea (HP:0007720)2.03456895
58Carpal bone hypoplasia (HP:0001498)2.03389875
59Gastrointestinal carcinoma (HP:0002672)2.02905953
60Malignant gastrointestinal tract tumors (HP:0006749)2.02905953
61Absent radius (HP:0003974)2.02566077
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.01724895
63Disproportionate tall stature (HP:0001519)2.00454655
64Agnosia (HP:0010524)1.99776923
65Increased connective tissue (HP:0009025)1.99191658
66Pseudobulbar signs (HP:0002200)1.98673596
67Skin tags (HP:0010609)1.97788661
68Aplasia/Hypoplasia of the patella (HP:0006498)1.97391684
69Premature rupture of membranes (HP:0001788)1.96879915
70Increased density of long bones (HP:0006392)1.95817055
71Advanced eruption of teeth (HP:0006288)1.94794492
72Cerebral aneurysm (HP:0004944)1.93955574
73Patellar dislocation (HP:0002999)1.93000952
74Sandal gap (HP:0001852)1.92878091
75Reticulocytopenia (HP:0001896)1.92851295
76Abnormality of the carotid arteries (HP:0005344)1.92635922
77Atresia of the external auditory canal (HP:0000413)1.92621856
78Vertebral arch anomaly (HP:0008438)1.92479540
79Abnormality of the lower motor neuron (HP:0002366)1.92240065
80Shallow orbits (HP:0000586)1.92118883
81Neoplasm of the pancreas (HP:0002894)1.91870682
82Broad thumb (HP:0011304)1.91804974
83Hyperacusis (HP:0010780)1.91715995
84Skull defect (HP:0001362)1.91345010
85Abnormality of oral frenula (HP:0000190)1.91149812
86Relative macrocephaly (HP:0004482)1.91128223
87Meckel diverticulum (HP:0002245)1.90374366
88Myelodysplasia (HP:0002863)1.90189865
89Natal tooth (HP:0000695)1.90182385
90Short 1st metacarpal (HP:0010034)1.88049277
91Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.88049277
9211 pairs of ribs (HP:0000878)1.87334822
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.87101398
94Sparse lateral eyebrow (HP:0005338)1.86753289
95Absent thumb (HP:0009777)1.84902065
96Dislocated radial head (HP:0003083)1.84095784
97Cutaneous melanoma (HP:0012056)1.83940780
98Preauricular skin tag (HP:0000384)1.83447723
99Squamous cell carcinoma (HP:0002860)1.83440529
100Absent forearm bone (HP:0003953)1.83225315
101Aplasia involving forearm bones (HP:0009822)1.83225315
102Ulnar bowing (HP:0003031)1.83144966
103Persistence of primary teeth (HP:0006335)1.82912533
104Supernumerary ribs (HP:0005815)1.82444863
105Abnormality of the ileum (HP:0001549)1.80806008
106Rectal prolapse (HP:0002035)1.79594297
107Impaired proprioception (HP:0010831)1.79553049
108Hypoplastic toenails (HP:0001800)1.77757538
109Obsessive-compulsive behavior (HP:0000722)1.77617252
110Poikiloderma (HP:0001029)1.76436434
111Progressive external ophthalmoplegia (HP:0000590)1.76374988
112Anal stenosis (HP:0002025)1.75822080
113Heterotopia (HP:0002282)1.75284876
114Pointed chin (HP:0000307)1.74950321
115Overlapping toe (HP:0001845)1.74312375
116Facial hemangioma (HP:0000329)1.73981108
117Multiple enchondromatosis (HP:0005701)1.73903412
118Intestinal fistula (HP:0100819)1.73319040
119Rib fusion (HP:0000902)1.73262751
120Bowel diverticulosis (HP:0005222)1.73140899
121Short phalanx of the thumb (HP:0009660)1.73050461
122Trismus (HP:0000211)1.72683468
123Limited elbow extension (HP:0001377)1.72566321
124Oral leukoplakia (HP:0002745)1.72442536
125Renal duplication (HP:0000075)1.72056044
126Shawl scrotum (HP:0000049)1.72004894
127Spinal muscular atrophy (HP:0007269)1.71536700
128Spina bifida occulta (HP:0003298)1.71461448
129Bladder diverticulum (HP:0000015)1.70439748
130Pelvic girdle muscle weakness (HP:0003749)1.70253778
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.69916095
132Supernumerary bones of the axial skeleton (HP:0009144)1.69798923
133Abnormality of the preputium (HP:0100587)1.69789882
134Abnormality of the radial head (HP:0003995)1.69710852
135Self-mutilation (HP:0000742)1.69510630
136Amaurosis fugax (HP:0100576)1.69303660
137Hypopigmentation of the fundus (HP:0007894)1.68376252
138Ovarian neoplasm (HP:0100615)1.67781786
139Broad palm (HP:0001169)1.66595040
140Fragile skin (HP:0001030)1.63375878
141Flat acetabular roof (HP:0003180)1.60366242
142Arnold-Chiari malformation (HP:0002308)1.60332486
143Achilles tendon contracture (HP:0001771)1.59888315
144Underdeveloped nasal alae (HP:0000430)1.56375779
145Bowed forearm bones (HP:0003956)1.55360244
146Bowing of the arm (HP:0006488)1.55360244
147Short chin (HP:0000331)1.54229565
148Sparse scalp hair (HP:0002209)1.53814663
149Duplication of thumb phalanx (HP:0009942)1.52772588
150Aplasia cutis congenita (HP:0001057)1.52093718
151Nephroblastoma (Wilms tumor) (HP:0002667)1.50704466
152Abnormality of chromosome segregation (HP:0002916)1.50100080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.47893902
2CDC74.05011170
3SMG13.66787788
4EEF2K3.28668374
5WEE12.88742998
6NEK22.60197277
7PKN22.39090056
8TTK2.35624382
9PBK2.27989222
10TSSK62.26726206
11NEK12.18460153
12TTN2.16114097
13BUB12.09384414
14MST1R2.03032214
15LATS11.90135686
16MAP3K101.89978377
17EPHA21.84934297
18RPS6KB21.76659371
19STK101.72805100
20TRIB31.72250805
21SRPK11.70974132
22CDK71.69505908
23CDK41.67563277
24BRD41.65815946
25FGFR41.61805835
26ALK1.57054077
27ATR1.52965412
28PLK11.49539146
29PASK1.47973326
30IRAK31.47248083
31MAP3K81.44207581
32MTOR1.43670903
33CHEK11.43474470
34MKNK11.42587793
35STK31.37975547
36AURKB1.35887247
37LATS21.23404347
38PLK31.22306288
39CHEK21.20874322
40RPS6KA41.20343254
41BRSK21.17351778
42SCYL21.17010038
43EIF2AK11.16292838
44CDK61.15645823
45TAF11.15017372
46STK41.11149605
47PAK41.10825642
48PNCK1.08224040
49ATM1.05296553
50TLK11.04868619
51MKNK21.04011977
52MAPK111.03899502
53FLT31.03361346
54TGFBR11.02809066
55CDK21.02095527
56MAP4K10.97008927
57PAK20.92900672
58ICK0.92748644
59PTK20.91826963
60PDGFRA0.89533298
61LRRK20.89232845
62CAMK1D0.86926679
63CDK80.86896520
64MELK0.86325168
65PIM10.85988492
66PTK60.83513814
67NEK90.83314856
68ERBB40.80552587
69WNK10.78091225
70FGFR10.77700101
71BMX0.76366962
72CDK10.71629424
73ACVR1B0.69154124
74AURKA0.68332395
75STK38L0.66788739
76PDK40.66329853
77PDK30.66329853
78MAP2K30.65624735
79ZAK0.63140760
80TESK20.61432596
81CSNK1E0.60984963
82PLK40.59916107
83AKT20.59845516
84MAP3K20.59557210
85RIPK10.59362854
86CSNK1D0.59212487
87RPS6KB10.58985404
88CSNK2A20.53940791
89FGFR30.53922950
90PRKDC0.52808121
91DYRK30.52478761
92NTRK10.49978561
93DMPK0.49158758
94CAMK1G0.49081705
95CDK90.48891200
96RPS6KA20.48727194
97MAPK140.47788040
98AKT30.45075904
99NME20.44422662
100BRSK10.43548143
101CHUK0.43383081
102SIK10.43109710
103PRKAA10.42760000
104KSR20.42120659
105PAK10.42071875
106EIF2AK20.41919041
107MARK30.41075085
108CLK10.39685190
109PRPF4B0.39083263
110JAK30.38691772
111MAPK10.38526298
112EIF2AK30.38515240
113NME10.38225345
114WNK40.37062892
115MET0.36783962
116PRKD20.36333028
117AKT10.35869390
118PRKD30.35429037
119MAPKAPK50.35345425
120FGFR20.34803741
121RPS6KC10.34122279
122RPS6KL10.34122279
123RPS6KA10.34062127
124GSK3B0.34027459
125GRK60.32733563
126CSF1R0.32347311
127MAPKAPK30.32321429
128DDR20.31659434
129TRPM70.31495224
130PDGFRB0.30766460
131RPS6KA50.30033376
132TYRO30.29695851

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.86323289
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.81739527
3One carbon pool by folate_Homo sapiens_hsa006703.49469751
4Mismatch repair_Homo sapiens_hsa034303.48355226
5RNA transport_Homo sapiens_hsa030133.40964961
6Spliceosome_Homo sapiens_hsa030402.99714103
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.92199150
8Cell cycle_Homo sapiens_hsa041102.73583199
9Base excision repair_Homo sapiens_hsa034102.46597467
10Nucleotide excision repair_Homo sapiens_hsa034202.22570664
11mRNA surveillance pathway_Homo sapiens_hsa030152.21166245
12Homologous recombination_Homo sapiens_hsa034402.09444941
13Fanconi anemia pathway_Homo sapiens_hsa034601.91070678
14Non-homologous end-joining_Homo sapiens_hsa034501.83576250
15RNA degradation_Homo sapiens_hsa030181.67653384
16Systemic lupus erythematosus_Homo sapiens_hsa053221.59497916
17p53 signaling pathway_Homo sapiens_hsa041151.57160888
18Ribosome_Homo sapiens_hsa030101.48533934
19* RNA polymerase_Homo sapiens_hsa030201.45872419
20Viral carcinogenesis_Homo sapiens_hsa052031.45178976
21MicroRNAs in cancer_Homo sapiens_hsa052061.36206764
22Selenocompound metabolism_Homo sapiens_hsa004501.34292346
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30962151
24Lysine degradation_Homo sapiens_hsa003101.27967457
25Biosynthesis of amino acids_Homo sapiens_hsa012301.25748029
26* Pyrimidine metabolism_Homo sapiens_hsa002401.23010246
27Small cell lung cancer_Homo sapiens_hsa052221.20828330
28Basal transcription factors_Homo sapiens_hsa030221.19381454
29N-Glycan biosynthesis_Homo sapiens_hsa005101.18071223
30Glioma_Homo sapiens_hsa052141.18017412
31HTLV-I infection_Homo sapiens_hsa051661.14574871
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12584110
33Epstein-Barr virus infection_Homo sapiens_hsa051691.08660923
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05877099
35Adherens junction_Homo sapiens_hsa045201.04560861
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04368048
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03844652
38Antigen processing and presentation_Homo sapiens_hsa046121.03122655
39mTOR signaling pathway_Homo sapiens_hsa041501.00806688
40Chronic myeloid leukemia_Homo sapiens_hsa052201.00569024
41Herpes simplex infection_Homo sapiens_hsa051680.98311411
42Hippo signaling pathway_Homo sapiens_hsa043900.97589379
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97535151
44Viral myocarditis_Homo sapiens_hsa054160.96522791
45Basal cell carcinoma_Homo sapiens_hsa052170.95943985
46Thyroid cancer_Homo sapiens_hsa052160.95268981
47Fatty acid biosynthesis_Homo sapiens_hsa000610.94647971
48Notch signaling pathway_Homo sapiens_hsa043300.94619889
49ErbB signaling pathway_Homo sapiens_hsa040120.92171700
50Renal cell carcinoma_Homo sapiens_hsa052110.91210380
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.90901681
52Oocyte meiosis_Homo sapiens_hsa041140.90575022
53TGF-beta signaling pathway_Homo sapiens_hsa043500.88188261
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.86908334
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.85992383
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85884012
57Melanoma_Homo sapiens_hsa052180.78478006
58Carbon metabolism_Homo sapiens_hsa012000.77895291
59Proteoglycans in cancer_Homo sapiens_hsa052050.75981261
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71350934
61Pentose phosphate pathway_Homo sapiens_hsa000300.70901063
62Proteasome_Homo sapiens_hsa030500.68885299
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66282886
64Bladder cancer_Homo sapiens_hsa052190.65907298
65Inositol phosphate metabolism_Homo sapiens_hsa005620.65077091
66Colorectal cancer_Homo sapiens_hsa052100.64788167
67Acute myeloid leukemia_Homo sapiens_hsa052210.64181140
68HIF-1 signaling pathway_Homo sapiens_hsa040660.63732906
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63016189
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62607790
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61453894
72Prostate cancer_Homo sapiens_hsa052150.58768856
73Fructose and mannose metabolism_Homo sapiens_hsa000510.57605528
74Pathways in cancer_Homo sapiens_hsa052000.57429790
75Focal adhesion_Homo sapiens_hsa045100.57408452
76Hedgehog signaling pathway_Homo sapiens_hsa043400.56698129
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.56317181
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56002291
79* Purine metabolism_Homo sapiens_hsa002300.53596585
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53436407
81Non-small cell lung cancer_Homo sapiens_hsa052230.53336078
82Vitamin B6 metabolism_Homo sapiens_hsa007500.52977562
83Apoptosis_Homo sapiens_hsa042100.51832853
84Legionellosis_Homo sapiens_hsa051340.51201308
85Hepatitis B_Homo sapiens_hsa051610.51028106
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50936716
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50889410
88VEGF signaling pathway_Homo sapiens_hsa043700.50455858
89Prolactin signaling pathway_Homo sapiens_hsa049170.50057398
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49501707
91Steroid biosynthesis_Homo sapiens_hsa001000.49234916
92Estrogen signaling pathway_Homo sapiens_hsa049150.49106220
93Tight junction_Homo sapiens_hsa045300.48169565
94Choline metabolism in cancer_Homo sapiens_hsa052310.48039222
95ECM-receptor interaction_Homo sapiens_hsa045120.47188718
96Thyroid hormone synthesis_Homo sapiens_hsa049180.45189980
97Sulfur relay system_Homo sapiens_hsa041220.45135021
98Alcoholism_Homo sapiens_hsa050340.44144562
99Arginine biosynthesis_Homo sapiens_hsa002200.43166481
100Endometrial cancer_Homo sapiens_hsa052130.42674085
101AMPK signaling pathway_Homo sapiens_hsa041520.41854943
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.41403010
103Pancreatic cancer_Homo sapiens_hsa052120.40273352
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.40053121
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37279357
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.36997711
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36237867
108Wnt signaling pathway_Homo sapiens_hsa043100.35730711
109Insulin resistance_Homo sapiens_hsa049310.35345895
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34663587
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33832604
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33281648
113FoxO signaling pathway_Homo sapiens_hsa040680.33162684
114Measles_Homo sapiens_hsa051620.33026441
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32941739
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32208949
117Insulin signaling pathway_Homo sapiens_hsa049100.31450929
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31191028
119B cell receptor signaling pathway_Homo sapiens_hsa046620.31140163
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30288663
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29899456
122Glucagon signaling pathway_Homo sapiens_hsa049220.29013864

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