POLR1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.11647738
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.95315994
3formation of translation preinitiation complex (GO:0001731)4.88335009
4nucleobase biosynthetic process (GO:0046112)4.87781626
5purine nucleobase biosynthetic process (GO:0009113)4.72746111
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.66360738
7ribosomal small subunit assembly (GO:0000028)4.63401758
8ribosomal small subunit biogenesis (GO:0042274)4.62637103
9viral transcription (GO:0019083)4.52515226
10translational termination (GO:0006415)4.47405370
11ribosomal large subunit biogenesis (GO:0042273)4.46865177
12ribonucleoprotein complex biogenesis (GO:0022613)4.33811337
13chaperone-mediated protein transport (GO:0072321)4.31990495
14mitotic metaphase plate congression (GO:0007080)4.30226832
15protein complex biogenesis (GO:0070271)4.26082262
16ribosome biogenesis (GO:0042254)4.25143443
17DNA strand elongation involved in DNA replication (GO:0006271)4.23077402
18ribosome assembly (GO:0042255)4.21809123
19ATP synthesis coupled proton transport (GO:0015986)4.21427757
20energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21427757
21mitochondrial respiratory chain complex assembly (GO:0033108)4.17328681
22DNA replication initiation (GO:0006270)4.16805195
23translational initiation (GO:0006413)4.11832650
24DNA replication checkpoint (GO:0000076)4.08049976
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08017235
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.08017235
27NADH dehydrogenase complex assembly (GO:0010257)4.08017235
28translational elongation (GO:0006414)4.03325061
29DNA strand elongation (GO:0022616)4.02253122
30DNA deamination (GO:0045006)3.91128706
31rRNA processing (GO:0006364)3.90243212
32spliceosomal snRNP assembly (GO:0000387)3.88680526
33protein localization to kinetochore (GO:0034501)3.88115016
34telomere maintenance via semi-conservative replication (GO:0032201)3.83550064
35proteasome assembly (GO:0043248)3.82553998
36regulation of mitochondrial translation (GO:0070129)3.80953715
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.77795106
38rRNA modification (GO:0000154)3.77770280
39rRNA metabolic process (GO:0016072)3.77162691
40respiratory chain complex IV assembly (GO:0008535)3.74927557
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.74626955
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70643155
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.69380638
44cotranslational protein targeting to membrane (GO:0006613)3.66837799
45DNA replication-dependent nucleosome organization (GO:0034723)3.66565641
46DNA replication-dependent nucleosome assembly (GO:0006335)3.66565641
47DNA unwinding involved in DNA replication (GO:0006268)3.66508726
48protein targeting to ER (GO:0045047)3.64602957
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63894616
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.61720592
51metaphase plate congression (GO:0051310)3.61254426
52cellular protein complex disassembly (GO:0043624)3.58564186
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56156153
54cytochrome complex assembly (GO:0017004)3.55421831
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.54954192
56IMP biosynthetic process (GO:0006188)3.54393910
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53099849
58CENP-A containing nucleosome assembly (GO:0034080)3.53010800
59rRNA methylation (GO:0031167)3.51161341
60viral life cycle (GO:0019058)3.49974535
61chromatin remodeling at centromere (GO:0031055)3.49774076
62protein deneddylation (GO:0000338)3.49254563
63mitotic nuclear envelope disassembly (GO:0007077)3.47791196
64telomere maintenance via recombination (GO:0000722)3.45984452
65establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45390061
66replication fork processing (GO:0031297)3.43391099
677-methylguanosine mRNA capping (GO:0006370)3.42683509
68protein localization to endoplasmic reticulum (GO:0070972)3.42064680
69protein targeting to mitochondrion (GO:0006626)3.41675506
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40226397
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40226397
72translation (GO:0006412)3.39382699
73water-soluble vitamin biosynthetic process (GO:0042364)3.38364601
747-methylguanosine RNA capping (GO:0009452)3.37287814
75RNA capping (GO:0036260)3.37287814
76pseudouridine synthesis (GO:0001522)3.37209388
77protein K6-linked ubiquitination (GO:0085020)3.35389784
78* transcription elongation from RNA polymerase III promoter (GO:0006385)3.34014841
79* termination of RNA polymerase III transcription (GO:0006386)3.34014841
80cellular component biogenesis (GO:0044085)3.33541163
81transcription-coupled nucleotide-excision repair (GO:0006283)3.33262107
82negative regulation of ligase activity (GO:0051352)3.32863201
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32863201
84mitotic recombination (GO:0006312)3.31773769
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31660023
86peptidyl-histidine modification (GO:0018202)3.30270287
87spliceosomal complex assembly (GO:0000245)3.28891210
88regulation of spindle organization (GO:0090224)3.28452005
89tRNA processing (GO:0008033)3.27517039
90DNA replication-independent nucleosome organization (GO:0034724)3.27407175
91DNA replication-independent nucleosome assembly (GO:0006336)3.27407175
92protein localization to chromosome, centromeric region (GO:0071459)3.26821367
93respiratory electron transport chain (GO:0022904)3.26753477
94establishment of protein localization to mitochondrion (GO:0072655)3.25219776
95protein complex disassembly (GO:0043241)3.24015466
96electron transport chain (GO:0022900)3.23812178
97nuclear pore organization (GO:0006999)3.23665295
98telomere maintenance via telomere lengthening (GO:0010833)3.23624236
99DNA double-strand break processing (GO:0000729)3.23574930
100kinetochore assembly (GO:0051382)3.23238531
101DNA catabolic process, exonucleolytic (GO:0000738)3.23090653
102protein localization to mitochondrion (GO:0070585)3.20868269
103* transcription elongation from RNA polymerase I promoter (GO:0006362)3.20787246
104kinetochore organization (GO:0051383)3.19945836
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.18070376
106DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17623210
107nuclear envelope disassembly (GO:0051081)3.17250895
108membrane disassembly (GO:0030397)3.17250895
109* termination of RNA polymerase I transcription (GO:0006363)3.16755600
110tRNA metabolic process (GO:0006399)3.15034471
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13365805
112intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13365805
113regulation of cellular amino acid metabolic process (GO:0006521)3.12985192
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12921387
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12921387
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12921387
117maturation of 5.8S rRNA (GO:0000460)3.12838918
118signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12601295
119signal transduction involved in DNA damage checkpoint (GO:0072422)3.12601295
120establishment of chromosome localization (GO:0051303)3.11613911
121cell cycle G1/S phase transition (GO:0044843)3.10043928
122G1/S transition of mitotic cell cycle (GO:0000082)3.10043928
123* transcription from RNA polymerase I promoter (GO:0006360)3.10020728
124signal transduction involved in cell cycle checkpoint (GO:0072395)3.08808391
125macromolecular complex disassembly (GO:0032984)3.07629802
126histone exchange (GO:0043486)3.05473972
127establishment of integrated proviral latency (GO:0075713)3.04607807
128nuclear-transcribed mRNA catabolic process (GO:0000956)3.04333497
129somatic hypermutation of immunoglobulin genes (GO:0016446)3.04240932
130somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04240932
131protein-cofactor linkage (GO:0018065)3.03459926
132ncRNA processing (GO:0034470)3.03356367
133cullin deneddylation (GO:0010388)3.03095150
134protein neddylation (GO:0045116)3.02924615
135mitochondrial RNA metabolic process (GO:0000959)3.01793160
136positive regulation of ligase activity (GO:0051351)3.01227211
137ncRNA metabolic process (GO:0034660)3.01088128
138folic acid metabolic process (GO:0046655)3.00485981
139regulation of posttranscriptional gene silencing (GO:0060147)2.97931204
140regulation of gene silencing by miRNA (GO:0060964)2.97931204
141regulation of gene silencing by RNA (GO:0060966)2.97931204
142transcription from mitochondrial promoter (GO:0006390)2.90564434
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.89489488
144regulation of mitotic spindle checkpoint (GO:1903504)2.89266032
145regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89266032
146RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87345021
147amino acid activation (GO:0043038)2.85729242
148tRNA aminoacylation (GO:0043039)2.85729242
149tRNA modification (GO:0006400)2.83575684
150maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82922467
151intracellular protein transmembrane import (GO:0044743)2.82741094
152tRNA aminoacylation for protein translation (GO:0006418)2.82108303
153GTP biosynthetic process (GO:0006183)2.81281277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07799636
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57522025
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65531440
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55602859
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.40004507
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.39632012
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.38347131
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.29688722
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27860977
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24315927
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.22460812
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14411433
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.05518044
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04530107
15CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02332760
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94511166
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72189041
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63372897
19XRN2_22483619_ChIP-Seq_HELA_Human2.47164003
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46567098
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38783303
22* VDR_23849224_ChIP-Seq_CD4+_Human2.35530317
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33562728
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31831244
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17656519
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12799499
27DCP1A_22483619_ChIP-Seq_HELA_Human2.10073165
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07054916
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.00313502
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.98887792
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98539649
32* TTF2_22483619_ChIP-Seq_HELA_Human1.96163171
33* GABP_19822575_ChIP-Seq_HepG2_Human1.96157641
34AR_21909140_ChIP-Seq_LNCAP_Human1.93951802
35ZNF274_21170338_ChIP-Seq_K562_Hela1.92751340
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92751171
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92563296
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.87831132
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80729340
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80084785
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76941941
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76832034
43* ELK1_19687146_ChIP-ChIP_HELA_Human1.71361819
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71074784
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.70572083
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65252264
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63968306
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62679557
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60338104
50IRF1_19129219_ChIP-ChIP_H3396_Human1.53862972
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53797231
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53416041
53* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51804572
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.51543121
55VDR_22108803_ChIP-Seq_LS180_Human1.49181662
56CIITA_25753668_ChIP-Seq_RAJI_Human1.47795096
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46886634
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45472669
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44452540
60KDM5A_27292631_Chip-Seq_BREAST_Human1.43096635
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39498076
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37292963
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35689923
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34423844
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34226191
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31193832
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29399838
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27272928
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26074473
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26074473
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26074473
72EWS_26573619_Chip-Seq_HEK293_Human1.23694323
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22478000
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.19685393
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18390454
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.16681889
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16335278
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15442028
79* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13950773
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.13818562
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.10649828
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10285083
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09992113
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08442806
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07085601
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06212948
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05304569
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04954633
89* NOTCH1_21737748_ChIP-Seq_TLL_Human1.02908241
90MYC_18940864_ChIP-ChIP_HL60_Human1.02777985
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01600900
92TFEB_21752829_ChIP-Seq_HELA_Human1.01441550
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00498814
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00488662
95FUS_26573619_Chip-Seq_HEK293_Human1.00316506
96TP53_22573176_ChIP-Seq_HFKS_Human0.99529896
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99063469
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.97304700
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96947828
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96844509
101SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96382116
102MYC_22102868_ChIP-Seq_BL_Human0.96286107
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95997202
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93833074
105POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93731632
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.93042522
107RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91347537
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90920062
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90223228
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88858039
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.88330510
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86978540
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84297947
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82866394
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.82174857
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.81985727
117TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81025435
118* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79813926
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78788245
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77931121
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75688667
122FOXP1_21924763_ChIP-Seq_HESCs_Human0.73662782
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71410732
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.70788333
125FOXA1_25329375_ChIP-Seq_VCAP_Human0.68265957
126FOXA1_27270436_Chip-Seq_PROSTATE_Human0.68265957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.90769012
2MP0004957_abnormal_blastocyst_morpholog4.79293476
3MP0003111_abnormal_nucleus_morphology4.60158382
4MP0010094_abnormal_chromosome_stability4.35971606
5MP0003077_abnormal_cell_cycle4.09510493
6MP0008057_abnormal_DNA_replication4.06182259
7MP0008058_abnormal_DNA_repair3.59408880
8MP0008932_abnormal_embryonic_tissue3.01840914
9MP0003123_paternal_imprinting2.83773185
10MP0008007_abnormal_cellular_replicative2.69511114
11MP0001730_embryonic_growth_arrest2.47297592
12MP0003786_premature_aging2.37630827
13MP0003718_maternal_effect2.24502403
14MP0000350_abnormal_cell_proliferation2.23553044
15MP0008877_abnormal_DNA_methylation2.21093150
16MP0006072_abnormal_retinal_apoptosis1.86320383
17MP0003646_muscle_fatigue1.85493132
18MP0005380_embryogenesis_phenotype1.81179885
19MP0001672_abnormal_embryogenesis/_devel1.81179885
20MP0001529_abnormal_vocalization1.81041931
21MP0000372_irregular_coat_pigmentation1.80544515
22MP0002837_dystrophic_cardiac_calcinosis1.79502068
23MP0010352_gastrointestinal_tract_polyps1.77564300
24MP0010030_abnormal_orbit_morphology1.74173181
25MP0003806_abnormal_nucleotide_metabolis1.73009913
26MP0001697_abnormal_embryo_size1.71160521
27MP0004133_heterotaxia1.70788726
28MP0009697_abnormal_copulation1.65856136
29MP0002080_prenatal_lethality1.62693317
30MP0002085_abnormal_embryonic_tissue1.62595614
31MP0003984_embryonic_growth_retardation1.60048187
32MP0005084_abnormal_gallbladder_morpholo1.58124273
33MP0003315_abnormal_perineum_morphology1.58008795
34MP0002396_abnormal_hematopoietic_system1.57114148
35MP0003567_abnormal_fetal_cardiomyocyte1.56736885
36MP0002088_abnormal_embryonic_growth/wei1.55979671
37MP0002163_abnormal_gland_morphology1.55352948
38MP0008872_abnormal_physiological_respon1.50168616
39MP0009333_abnormal_splenocyte_physiolog1.48209973
40MP0008875_abnormal_xenobiotic_pharmacok1.45779165
41MP0002736_abnormal_nociception_after1.45230818
42MP0002084_abnormal_developmental_patter1.43101780
43MP0002210_abnormal_sex_determination1.41303336
44MP0000313_abnormal_cell_death1.36141915
45MP0010307_abnormal_tumor_latency1.35670400
46MP0005499_abnormal_olfactory_system1.35204230
47MP0005394_taste/olfaction_phenotype1.35204230
48MP0005646_abnormal_pituitary_gland1.34874415
49MP0001293_anophthalmia1.34647866
50MP0003890_abnormal_embryonic-extraembry1.34205264
51MP0000490_abnormal_crypts_of1.31326611
52MP0005551_abnormal_eye_electrophysiolog1.30818541
53MP0002086_abnormal_extraembryonic_tissu1.30446219
54MP0002653_abnormal_ependyma_morphology1.30078584
55MP0006292_abnormal_olfactory_placode1.28140355
56MP0004197_abnormal_fetal_growth/weight/1.27230502
57MP0005379_endocrine/exocrine_gland_phen1.26803888
58MP0001968_abnormal_touch/_nociception1.24934625
59MP0002277_abnormal_respiratory_mucosa1.24715667
60MP0009379_abnormal_foot_pigmentation1.24523051
61MP0003121_genomic_imprinting1.24118274
62MP0001145_abnormal_male_reproductive1.23768717
63MP0003119_abnormal_digestive_system1.21890681
64MP0002019_abnormal_tumor_incidence1.21032345
65MP0004142_abnormal_muscle_tone1.19538693
66MP0000631_abnormal_neuroendocrine_gland1.19291956
67MP0003195_calcinosis1.18410897
68MP0000537_abnormal_urethra_morphology1.17126588
69MP0005253_abnormal_eye_physiology1.16079640
70MP0003186_abnormal_redox_activity1.13281734
71MP0001919_abnormal_reproductive_system1.12901493
72MP0004147_increased_porphyrin_level1.10994141
73MP0003787_abnormal_imprinting1.10137362
74MP0001929_abnormal_gametogenesis1.09541309
75MP0005075_abnormal_melanosome_morpholog1.05677812
76MP0002132_abnormal_respiratory_system1.03874158
77MP0000653_abnormal_sex_gland1.03599965
78MP0002160_abnormal_reproductive_system1.03590113
79MP0003941_abnormal_skin_development1.02006572
80MP0001764_abnormal_homeostasis1.01864479
81MP0003011_delayed_dark_adaptation0.99174649
82MP0002938_white_spotting0.97782787
83MP0001986_abnormal_taste_sensitivity0.97411867
84MP0001485_abnormal_pinna_reflex0.97147704
85MP0001905_abnormal_dopamine_level0.97095130
86MP0002095_abnormal_skin_pigmentation0.95983714
87MP0006035_abnormal_mitochondrial_morpho0.95118907
88MP0003221_abnormal_cardiomyocyte_apopto0.93965925
89MP0002111_abnormal_tail_morphology0.93739949
90MP0003937_abnormal_limbs/digits/tail_de0.93473256
91MP0000358_abnormal_cell_content/0.92206357
92MP0005377_hearing/vestibular/ear_phenot0.90345083
93MP0003878_abnormal_ear_physiology0.90345083
94MP0005645_abnormal_hypothalamus_physiol0.90294450
95MP0003136_yellow_coat_color0.89696051
96MP0005410_abnormal_fertilization0.87426801
97MP0006276_abnormal_autonomic_nervous0.87154407
98MP0005408_hypopigmentation0.87060265
99MP0001727_abnormal_embryo_implantation0.86687245
100MP0004808_abnormal_hematopoietic_stem0.85568803
101MP0005332_abnormal_amino_acid0.84237219
102MP0009046_muscle_twitch0.84014900
103MP0005389_reproductive_system_phenotype0.83125728
104MP0002234_abnormal_pharynx_morphology0.82979235
105MP0009053_abnormal_anal_canal0.81362945
106MP0002254_reproductive_system_inflammat0.81024848
107MP0001119_abnormal_female_reproductive0.80191561
108MP0001286_abnormal_eye_development0.79350461
109MP0005174_abnormal_tail_pigmentation0.79029688
110MP0000647_abnormal_sebaceous_gland0.76154836
111MP0000703_abnormal_thymus_morphology0.73819177
112MP0005384_cellular_phenotype0.73605062
113MP0002638_abnormal_pupillary_reflex0.73312683
114MP0002233_abnormal_nose_morphology0.73056136
115MP0005195_abnormal_posterior_eye0.72362502
116MP0008789_abnormal_olfactory_epithelium0.70254206
117MP0003938_abnormal_ear_development0.69364171
118MP0008260_abnormal_autophagy0.69247187
119MP0000015_abnormal_ear_pigmentation0.69037999
120MP0000427_abnormal_hair_cycle0.68594146
121MP0006036_abnormal_mitochondrial_physio0.68162672
122MP0002138_abnormal_hepatobiliary_system0.67918560
123MP0005395_other_phenotype0.67871696
124MP0009672_abnormal_birth_weight0.67731472
125MP0000516_abnormal_urinary_system0.67375316
126MP0005367_renal/urinary_system_phenotyp0.67375316
127MP0001542_abnormal_bone_strength0.67366143
128MP0002722_abnormal_immune_system0.66193323
129MP0000049_abnormal_middle_ear0.66011375
130MP0005391_vision/eye_phenotype0.64460840
131MP0002102_abnormal_ear_morphology0.64438771
132MP0005397_hematopoietic_system_phenotyp0.63925095
133MP0001545_abnormal_hematopoietic_system0.63925095
134MP0002092_abnormal_eye_morphology0.63698873
135MP0000750_abnormal_muscle_regeneration0.63383988
136MP0005621_abnormal_cell_physiology0.63310608
137MP0003936_abnormal_reproductive_system0.62507195
138MP0000689_abnormal_spleen_morphology0.62391669
139MP0000432_abnormal_head_morphology0.62201596
140MP0008995_early_reproductive_senescence0.60962954
141MP0002751_abnormal_autonomic_nervous0.59729037
142MP0003763_abnormal_thymus_physiology0.59173036
143MP0005266_abnormal_metabolism0.58893624
144MP0003698_abnormal_male_reproductive0.58718209
145MP0009703_decreased_birth_body0.57942245
146MP0000858_altered_metastatic_potential0.57740973
147MP0002161_abnormal_fertility/fecundity0.55792540
148MP0002127_abnormal_cardiovascular_syste0.55364983
149MP0005076_abnormal_cell_differentiation0.55031888

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.53411619
2Breast hypoplasia (HP:0003187)5.03281287
3Reticulocytopenia (HP:0001896)4.75423658
4Abnormality of cells of the erythroid lineage (HP:0012130)4.38864579
5Acute encephalopathy (HP:0006846)4.04542199
6Abnormal number of erythroid precursors (HP:0012131)4.02226268
7Abnormal mitochondria in muscle tissue (HP:0008316)3.96961301
8Carpal bone hypoplasia (HP:0001498)3.91672306
9Increased CSF lactate (HP:0002490)3.81661981
10Cerebral hypomyelination (HP:0006808)3.79805583
11Mitochondrial inheritance (HP:0001427)3.78241243
12Rough bone trabeculation (HP:0100670)3.77743938
13Oral leukoplakia (HP:0002745)3.65122657
14Patellar aplasia (HP:0006443)3.61552204
15Progressive macrocephaly (HP:0004481)3.59761232
16Macrocytic anemia (HP:0001972)3.49535851
17Increased hepatocellular lipid droplets (HP:0006565)3.47004606
18Aplasia/Hypoplasia of the patella (HP:0006498)3.41828130
19Hepatocellular necrosis (HP:0001404)3.33476547
20Lipid accumulation in hepatocytes (HP:0006561)3.31895012
21Colon cancer (HP:0003003)3.30965465
22Pancreatic cysts (HP:0001737)3.15597488
23Abnormality of midbrain morphology (HP:0002418)3.15102010
24Molar tooth sign on MRI (HP:0002419)3.15102010
25Absent radius (HP:0003974)3.14409677
26Abnormality of the labia minora (HP:0012880)3.13423449
27Abnormality of the anterior horn cell (HP:0006802)3.13002475
28Degeneration of anterior horn cells (HP:0002398)3.13002475
29Selective tooth agenesis (HP:0001592)3.07238747
303-Methylglutaconic aciduria (HP:0003535)3.06603724
31Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06158026
32Chromsome breakage (HP:0040012)3.05073789
33Hepatic necrosis (HP:0002605)3.02823875
34Pancreatic fibrosis (HP:0100732)2.99909184
35Impulsivity (HP:0100710)2.99837582
36Meckel diverticulum (HP:0002245)2.98761670
37Pallor (HP:0000980)2.94127518
38Aplasia involving forearm bones (HP:0009822)2.91967129
39Absent forearm bone (HP:0003953)2.91967129
40Absent thumb (HP:0009777)2.83329448
41Cerebral edema (HP:0002181)2.82933478
42Aplastic anemia (HP:0001915)2.82486880
43Abnormality of the ileum (HP:0001549)2.80910636
44Abnormality of the preputium (HP:0100587)2.79518710
45Abnormal trabecular bone morphology (HP:0100671)2.77648390
46Supernumerary spleens (HP:0009799)2.77154355
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.74531886
48Renal Fanconi syndrome (HP:0001994)2.71840704
49True hermaphroditism (HP:0010459)2.71806642
50Lactic acidosis (HP:0003128)2.61446458
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60886420
52Medulloblastoma (HP:0002885)2.57823074
53Horseshoe kidney (HP:0000085)2.56861942
54Premature graying of hair (HP:0002216)2.56220555
55Premature ovarian failure (HP:0008209)2.56174758
56Nephronophthisis (HP:0000090)2.52712189
57Methylmalonic acidemia (HP:0002912)2.51869283
58Methylmalonic aciduria (HP:0012120)2.47481519
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47067336
60Type II lissencephaly (HP:0007260)2.46924641
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.46462890
62Ependymoma (HP:0002888)2.44394016
63Pendular nystagmus (HP:0012043)2.43777102
64Abnormality of alanine metabolism (HP:0010916)2.43123700
65Hyperalaninemia (HP:0003348)2.43123700
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43123700
67Abnormality of chromosome stability (HP:0003220)2.42748587
68Secondary amenorrhea (HP:0000869)2.42358674
69Abnormal lung lobation (HP:0002101)2.39325094
70Neoplasm of the pancreas (HP:0002894)2.37864885
71Agnosia (HP:0010524)2.36839660
72Abnormal number of incisors (HP:0011064)2.35451408
73Triphalangeal thumb (HP:0001199)2.33591195
74Cellular immunodeficiency (HP:0005374)2.33328280
7511 pairs of ribs (HP:0000878)2.33084244
76Duodenal stenosis (HP:0100867)2.31662903
77Small intestinal stenosis (HP:0012848)2.31662903
78Hypoplasia of the pons (HP:0012110)2.31347752
79Abnormality of the pons (HP:0007361)2.29904421
80Optic disc pallor (HP:0000543)2.29006780
81Microretrognathia (HP:0000308)2.28555080
82Type I transferrin isoform profile (HP:0003642)2.25506206
83Bone marrow hypocellularity (HP:0005528)2.23708878
84Bile duct proliferation (HP:0001408)2.21342601
85Abnormal biliary tract physiology (HP:0012439)2.21342601
86CNS hypomyelination (HP:0003429)2.19206925
87Myelodysplasia (HP:0002863)2.18991227
88Increased intramyocellular lipid droplets (HP:0012240)2.17770738
89Hypoplasia of the radius (HP:0002984)2.17601825
90Respiratory failure (HP:0002878)2.16998329
91Ureteral duplication (HP:0000073)2.15347634
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.14992466
93* Trismus (HP:0000211)2.14921014
94Increased serum pyruvate (HP:0003542)2.14825825
95Abnormality of glycolysis (HP:0004366)2.14825825
96Lethargy (HP:0001254)2.13332253
97* Tracheoesophageal fistula (HP:0002575)2.12690089
98Irregular epiphyses (HP:0010582)2.10839168
99Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10521323
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10521323
101Exercise intolerance (HP:0003546)2.10281874
102Medial flaring of the eyebrow (HP:0010747)2.09261911
103Abnormality of the umbilical cord (HP:0010881)2.08549621
104Short thumb (HP:0009778)2.07914179
105Sloping forehead (HP:0000340)2.07345117
106Rhabdomyosarcoma (HP:0002859)2.06388114
107Stenosis of the external auditory canal (HP:0000402)2.06328905
108Hyperglycinemia (HP:0002154)2.05850334
109Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05437553
110Breast aplasia (HP:0100783)2.04437978
111Aplasia/hypoplasia of the humerus (HP:0006507)2.02332724
112Abnormal protein glycosylation (HP:0012346)2.02007222
113Abnormal glycosylation (HP:0012345)2.02007222
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02007222
115Abnormal protein N-linked glycosylation (HP:0012347)2.02007222
116Sclerocornea (HP:0000647)2.00356869
117Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00277631
118Asplenia (HP:0001746)1.96495922
119Abnormality of the duodenum (HP:0002246)1.96044433
120Aplasia/Hypoplasia of the breasts (HP:0010311)1.95418201
121Abnormal umbilical cord blood vessels (HP:0011403)1.95124268
122Single umbilical artery (HP:0001195)1.95124268
123Abnormality of the fetal cardiovascular system (HP:0010948)1.95124268
124Ectopic kidney (HP:0000086)1.93708155
125Aplasia/hypoplasia of the uterus (HP:0008684)1.92966846
126Testicular atrophy (HP:0000029)1.91918078
127Sparse eyelashes (HP:0000653)1.91854828
128Increased serum lactate (HP:0002151)1.91659290
129Cerebellar dysplasia (HP:0007033)1.91616822
130* Atresia of the external auditory canal (HP:0000413)1.91081025
131Leukodystrophy (HP:0002415)1.90900455
132Pancytopenia (HP:0001876)1.90707734
133Duplicated collecting system (HP:0000081)1.90350778
134Abnormality of the renal medulla (HP:0100957)1.89840348
135Abnormality of the renal collecting system (HP:0004742)1.89310675
136Abnormality of DNA repair (HP:0003254)1.88035895
137Abdominal situs inversus (HP:0003363)1.86963065
138Abnormality of abdominal situs (HP:0011620)1.86963065
139Abnormality of serum amino acid levels (HP:0003112)1.84917538
140Abolished electroretinogram (ERG) (HP:0000550)1.83915580
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.83425365
142Missing ribs (HP:0000921)1.82889646
143Postnatal microcephaly (HP:0005484)1.81782440
144Exertional dyspnea (HP:0002875)1.81463523
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.80500395
146Congenital, generalized hypertrichosis (HP:0004540)1.80046356
147Retinal dysplasia (HP:0007973)1.79873635
148* Cleft eyelid (HP:0000625)1.79597786
149Congenital stationary night blindness (HP:0007642)1.79551815
150Microvesicular hepatic steatosis (HP:0001414)1.78727139
151Supernumerary bones of the axial skeleton (HP:0009144)1.77799251
152Squamous cell carcinoma (HP:0002860)1.77697546
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76919207
154Absent epiphyses (HP:0010577)1.76919207
155Increased muscle lipid content (HP:0009058)1.76831610
156CNS demyelination (HP:0007305)1.76682551
157Abnormality of methionine metabolism (HP:0010901)1.76626520
158Acute necrotizing encephalopathy (HP:0006965)1.75825090
159Male pseudohermaphroditism (HP:0000037)1.75816369
160Respiratory difficulties (HP:0002880)1.75364967
161Megaloblastic anemia (HP:0001889)1.73987892
162Short tibia (HP:0005736)1.73767025
163Reduced antithrombin III activity (HP:0001976)1.73623186
164Adrenal hypoplasia (HP:0000835)1.72952141
165Abnormality of urine glucose concentration (HP:0011016)1.72583961
166Glycosuria (HP:0003076)1.72583961
167Abnormality of pyrimidine metabolism (HP:0004353)1.72328135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.36131174
2WEE14.86117033
3VRK23.81055523
4EIF2AK13.33175531
5CDC73.13865490
6TSSK62.88745395
7SRPK12.79874418
8NME22.78277432
9STK162.65895486
10PLK42.38554565
11NUAK12.38215706
12BRSK22.28459869
13NEK22.22039442
14EIF2AK32.14969873
15TTK2.13279410
16PLK12.05450530
17EPHA21.96866831
18BMPR1B1.94250579
19VRK11.93912029
20ACVR1B1.91011495
21PLK31.81586403
22NEK11.80485222
23FRK1.77933979
24MKNK11.77391705
25WNK31.73906660
26TLK11.72235631
27CDK71.69809798
28MAP4K21.67712148
29DYRK31.67703123
30TRIM281.59473006
31TAF11.58418632
32GRK11.57994142
33AURKB1.57398508
34RPS6KB21.48417216
35CCNB11.43312235
36ADRBK21.43159492
37MKNK21.41677322
38PASK1.40670276
39AURKA1.40644921
40PIM21.37534328
41ATR1.36765730
42BRSK11.35705754
43CHEK21.29597262
44WNK41.23552323
45TESK21.16703455
46CHEK11.13423068
47PNCK1.12700038
48ZAK1.11292396
49RPS6KA41.09468024
50CDK41.08356150
51MAP3K81.07911620
52PBK1.06831413
53NME11.06092648
54AKT31.04451556
55PAK40.98494683
56BRAF0.95733318
57PRKCI0.95299721
58TGFBR10.93348636
59CDK120.93210208
60MST40.89417672
61PDK40.88681639
62PDK30.88681639
63OXSR10.87965658
64EIF2AK20.86198601
65PIM10.84713750
66MAP3K120.84615656
67CSNK1G10.82491189
68CSNK2A20.81983616
69PINK10.81094086
70DAPK10.79266795
71DYRK20.78989888
72CDK20.78983669
73TNIK0.78298361
74STK38L0.77963761
75PAK10.77440177
76CSNK2A10.75766449
77STK390.73555032
78PDK20.73048953
79STK40.72824271
80ATM0.70750119
81STK100.69801251
82CDK80.69129929
83PRKCG0.67424590
84CSNK1G20.65656304
85PLK20.65157184
86MAP3K110.64711238
87ARAF0.64500251
88ALK0.63156242
89BCKDK0.60978262
90RPS6KA50.60823218
91INSRR0.59478427
92CDK10.59241568
93CSNK1A1L0.54400657
94LATS20.53799571
95MAP3K30.53736048
96PAK30.52874830
97MELK0.52385184
98KDR0.52298530
99TXK0.51549566
100MAPKAPK30.51179605
101MAPK130.46954767
102MAP2K70.46136802
103BRD40.44812115
104ABL20.43628831
105MAPKAPK50.42902296
106MAP2K30.42453819
107TESK10.42408621
108STK30.39634187
109CSNK1E0.38434736
110MAP3K40.38315234
111LRRK20.36637169
112SCYL20.34523787
113AKT20.34331208
114CSNK1A10.33841472
115ERBB30.29666553
116MARK30.29484112
117CLK10.29257631
118PHKG10.29042471
119PHKG20.29042471
120TAOK30.28755687
121TAOK20.28085489
122IKBKB0.27990821
123FLT30.27320808
124ADRBK10.26223345
125CSNK1G30.25380182
126MAP4K10.24330420
127MAP2K20.24194037
128LIMK10.23291017
129PRKCQ0.21837961
130TIE10.21244329
131EEF2K0.20385565
132ZAP700.20256336
133PRKDC0.20024002
134ILK0.19523526
135MET0.18014841
136MTOR0.17674195
137STK240.17610133
138CDK60.17274868

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.39442763
2Proteasome_Homo sapiens_hsa030504.24030135
3DNA replication_Homo sapiens_hsa030304.23181362
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.13952305
5* RNA polymerase_Homo sapiens_hsa030203.94471121
6Mismatch repair_Homo sapiens_hsa034303.74322344
7Spliceosome_Homo sapiens_hsa030403.41829568
8RNA transport_Homo sapiens_hsa030133.26727523
9Homologous recombination_Homo sapiens_hsa034402.91254150
10Base excision repair_Homo sapiens_hsa034102.75999963
11Nucleotide excision repair_Homo sapiens_hsa034202.67309615
12* Pyrimidine metabolism_Homo sapiens_hsa002402.63510086
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38176021
14Cell cycle_Homo sapiens_hsa041102.38048993
15One carbon pool by folate_Homo sapiens_hsa006702.28369093
16Basal transcription factors_Homo sapiens_hsa030222.23052289
17Fanconi anemia pathway_Homo sapiens_hsa034602.05891539
18RNA degradation_Homo sapiens_hsa030181.81097279
19Vitamin B6 metabolism_Homo sapiens_hsa007501.73275434
20Non-homologous end-joining_Homo sapiens_hsa034501.63153781
21mRNA surveillance pathway_Homo sapiens_hsa030151.58395030
22Propanoate metabolism_Homo sapiens_hsa006401.43594775
23* Purine metabolism_Homo sapiens_hsa002301.43436149
24p53 signaling pathway_Homo sapiens_hsa041151.40725693
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32200475
26* Epstein-Barr virus infection_Homo sapiens_hsa051691.23186899
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19447939
28Steroid biosynthesis_Homo sapiens_hsa001001.19008043
29Sulfur metabolism_Homo sapiens_hsa009201.17780568
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16152257
31Huntingtons disease_Homo sapiens_hsa050161.12983143
32* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12502510
33Oxidative phosphorylation_Homo sapiens_hsa001901.07523757
34Parkinsons disease_Homo sapiens_hsa050121.05601726
35Fatty acid elongation_Homo sapiens_hsa000621.04898300
36Protein export_Homo sapiens_hsa030601.03485610
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.02368435
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00181272
39Biosynthesis of amino acids_Homo sapiens_hsa012300.93933348
40Systemic lupus erythematosus_Homo sapiens_hsa053220.93636726
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.91970714
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88575155
43Pentose phosphate pathway_Homo sapiens_hsa000300.86363449
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.86002374
45Cardiac muscle contraction_Homo sapiens_hsa042600.85171291
46Phototransduction_Homo sapiens_hsa047440.84304585
47Folate biosynthesis_Homo sapiens_hsa007900.82345193
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81652607
49Butanoate metabolism_Homo sapiens_hsa006500.80451094
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79593900
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78675109
52Oocyte meiosis_Homo sapiens_hsa041140.76429112
53Peroxisome_Homo sapiens_hsa041460.76265075
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76139311
55Glutathione metabolism_Homo sapiens_hsa004800.74054203
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.73596487
57Tryptophan metabolism_Homo sapiens_hsa003800.71873612
58Caffeine metabolism_Homo sapiens_hsa002320.69578074
59Herpes simplex infection_Homo sapiens_hsa051680.69294181
60Sulfur relay system_Homo sapiens_hsa041220.68406804
61Antigen processing and presentation_Homo sapiens_hsa046120.67776557
62Viral carcinogenesis_Homo sapiens_hsa052030.67241069
63Selenocompound metabolism_Homo sapiens_hsa004500.64590540
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61659283
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58596159
66Nitrogen metabolism_Homo sapiens_hsa009100.58126619
67Carbon metabolism_Homo sapiens_hsa012000.53775731
68HTLV-I infection_Homo sapiens_hsa051660.52508049
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49490874
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49153257
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48938097
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48687628
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47969854
74Legionellosis_Homo sapiens_hsa051340.45218690
75Chemical carcinogenesis_Homo sapiens_hsa052040.44608161
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43932699
77Alzheimers disease_Homo sapiens_hsa050100.41713804
78Basal cell carcinoma_Homo sapiens_hsa052170.41303663
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40895532
80Fructose and mannose metabolism_Homo sapiens_hsa000510.40814002
81Hippo signaling pathway_Homo sapiens_hsa043900.40227433
82Regulation of autophagy_Homo sapiens_hsa041400.40138467
83TGF-beta signaling pathway_Homo sapiens_hsa043500.39334070
84Collecting duct acid secretion_Homo sapiens_hsa049660.39155098
85Fatty acid metabolism_Homo sapiens_hsa012120.39010846
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38815588
87* Metabolic pathways_Homo sapiens_hsa011000.37471179
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36532012
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36424283
90beta-Alanine metabolism_Homo sapiens_hsa004100.35026185
91Small cell lung cancer_Homo sapiens_hsa052220.34428793
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34003104
93Retinol metabolism_Homo sapiens_hsa008300.33227598
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32847530
95Ether lipid metabolism_Homo sapiens_hsa005650.31364737
96Thyroid cancer_Homo sapiens_hsa052160.31315977
97Arachidonic acid metabolism_Homo sapiens_hsa005900.30684014
98Fat digestion and absorption_Homo sapiens_hsa049750.30021616
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29889585
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29815995
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29766258
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29080108
103MicroRNAs in cancer_Homo sapiens_hsa052060.28860052
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.28255479
105Fatty acid degradation_Homo sapiens_hsa000710.28150250
106Hedgehog signaling pathway_Homo sapiens_hsa043400.25998039
107Apoptosis_Homo sapiens_hsa042100.24892294
108Nicotine addiction_Homo sapiens_hsa050330.24852096
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24449396
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23890096
111Alcoholism_Homo sapiens_hsa050340.23076739
112Arginine and proline metabolism_Homo sapiens_hsa003300.22782320
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22781400
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.21586190
115HIF-1 signaling pathway_Homo sapiens_hsa040660.21373712
116Primary immunodeficiency_Homo sapiens_hsa053400.20636576
117Olfactory transduction_Homo sapiens_hsa047400.19653744
118Galactose metabolism_Homo sapiens_hsa000520.19320197
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18928715
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18362185
121Tyrosine metabolism_Homo sapiens_hsa003500.18326449
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.17611601
123Linoleic acid metabolism_Homo sapiens_hsa005910.15517433
124Vitamin digestion and absorption_Homo sapiens_hsa049770.15481850
125Asthma_Homo sapiens_hsa053100.14565473
126Pathways in cancer_Homo sapiens_hsa052000.12329884
127Notch signaling pathway_Homo sapiens_hsa043300.11492538
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10763036
129Colorectal cancer_Homo sapiens_hsa052100.10039460
130Measles_Homo sapiens_hsa051620.09852190
131Tight junction_Homo sapiens_hsa045300.08738213
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.08569090
133N-Glycan biosynthesis_Homo sapiens_hsa005100.06281902
134Pyruvate metabolism_Homo sapiens_hsa006200.06149697
135Allograft rejection_Homo sapiens_hsa053300.05371738
136Shigellosis_Homo sapiens_hsa051310.05097959
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04298733
138Renin-angiotensin system_Homo sapiens_hsa046140.01988291
139Graft-versus-host disease_Homo sapiens_hsa053320.01654514

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