POLR1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.14459479
2translational termination (GO:0006415)6.95941103
3ribosomal small subunit assembly (GO:0000028)6.88233505
4ribosomal small subunit biogenesis (GO:0042274)6.58595909
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.09939263
6translational elongation (GO:0006414)6.08655468
7cotranslational protein targeting to membrane (GO:0006613)5.96672286
8protein targeting to ER (GO:0045047)5.96109331
9maturation of SSU-rRNA (GO:0030490)5.95622331
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.68090949
11translational initiation (GO:0006413)5.62800655
12protein localization to endoplasmic reticulum (GO:0070972)5.61402077
13ribosomal large subunit biogenesis (GO:0042273)5.52532126
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.50324968
15viral life cycle (GO:0019058)5.46246982
16cellular protein complex disassembly (GO:0043624)5.43840476
17DNA deamination (GO:0045006)5.16669264
18formation of translation preinitiation complex (GO:0001731)4.75650493
19protein complex disassembly (GO:0043241)4.73366208
20ribonucleoprotein complex biogenesis (GO:0022613)4.65322170
21translation (GO:0006412)4.46956970
22macromolecular complex disassembly (GO:0032984)4.46153024
23nuclear-transcribed mRNA catabolic process (GO:0000956)4.10748082
24protein targeting to membrane (GO:0006612)3.97501353
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.95963556
26DNA strand elongation involved in DNA replication (GO:0006271)3.93529529
27mRNA catabolic process (GO:0006402)3.89438970
28rRNA processing (GO:0006364)3.88964027
29proteasome assembly (GO:0043248)3.86814082
30telomere maintenance via semi-conservative replication (GO:0032201)3.78578640
31rRNA metabolic process (GO:0016072)3.74373224
32DNA strand elongation (GO:0022616)3.73470217
33RNA catabolic process (GO:0006401)3.70016357
34ribosome biogenesis (GO:0042254)3.67110326
35cellular component biogenesis (GO:0044085)3.65755359
36rRNA methylation (GO:0031167)3.57392033
37DNA replication initiation (GO:0006270)3.57379430
38chaperone-mediated protein transport (GO:0072321)3.48840735
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.46261327
40ribosome assembly (GO:0042255)3.40804297
41protein targeting to mitochondrion (GO:0006626)3.40158009
42spliceosomal snRNP assembly (GO:0000387)3.40122647
43oxidative phosphorylation (GO:0006119)3.37945808
44pseudouridine synthesis (GO:0001522)3.36977817
45DNA replication checkpoint (GO:0000076)3.34824916
46telomere maintenance via recombination (GO:0000722)3.32388478
47nucleobase biosynthetic process (GO:0046112)3.27309046
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24004628
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23105103
50rRNA modification (GO:0000154)3.20952969
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20179605
52regulation of mitochondrial translation (GO:0070129)3.20129440
53respiratory electron transport chain (GO:0022904)3.19392438
54negative regulation of ligase activity (GO:0051352)3.18301575
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18301575
56* transcription elongation from RNA polymerase III promoter (GO:0006385)3.18161308
57* termination of RNA polymerase III transcription (GO:0006386)3.18161308
58protein targeting (GO:0006605)3.14491396
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13177173
60establishment of protein localization to mitochondrion (GO:0072655)3.11905748
61folic acid-containing compound biosynthetic process (GO:0009396)3.10611547
62electron transport chain (GO:0022900)3.10343314
63inner mitochondrial membrane organization (GO:0007007)3.08389091
64purine nucleobase biosynthetic process (GO:0009113)3.08327206
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.08272243
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.08272243
67protein localization to mitochondrion (GO:0070585)3.08019540
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05834495
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05834495
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05834495
71CENP-A containing nucleosome assembly (GO:0034080)3.04139813
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01798257
73mitotic recombination (GO:0006312)3.01417232
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01050546
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.01050546
76chromatin remodeling at centromere (GO:0031055)3.00457800
77transcription from mitochondrial promoter (GO:0006390)2.99497728
78telomere maintenance via telomere lengthening (GO:0010833)2.98948311
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98668062
80DNA unwinding involved in DNA replication (GO:0006268)2.96977473
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96249586
82spliceosomal complex assembly (GO:0000245)2.95831286
83regulation of cellular amino acid metabolic process (GO:0006521)2.95573629
84establishment of integrated proviral latency (GO:0075713)2.95380826
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.95180015
86establishment of protein localization to organelle (GO:0072594)2.94937870
87mitotic metaphase plate congression (GO:0007080)2.92978472
88negative regulation of RNA splicing (GO:0033119)2.90901393
89transcription-coupled nucleotide-excision repair (GO:0006283)2.90764908
907-methylguanosine mRNA capping (GO:0006370)2.89720373
91regulation of mitotic spindle checkpoint (GO:1903504)2.89559673
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89559673
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87283573
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86796249
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86616445
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84414592
97mitochondrial respiratory chain complex I assembly (GO:0032981)2.84134744
98NADH dehydrogenase complex assembly (GO:0010257)2.84134744
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84134744
100protein complex biogenesis (GO:0070271)2.82696236
1017-methylguanosine RNA capping (GO:0009452)2.82310844
102RNA capping (GO:0036260)2.82310844
103DNA replication-dependent nucleosome assembly (GO:0006335)2.82124276
104DNA replication-dependent nucleosome organization (GO:0034723)2.82124276
105nucleobase-containing small molecule interconversion (GO:0015949)2.81467948
106protein localization to kinetochore (GO:0034501)2.81389455
107G1/S transition of mitotic cell cycle (GO:0000082)2.80127735
108cell cycle G1/S phase transition (GO:0044843)2.80127735
109nucleotide-excision repair, DNA gap filling (GO:0006297)2.79737774
110mitotic nuclear envelope disassembly (GO:0007077)2.79491358
111ncRNA processing (GO:0034470)2.77768249
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74923481
113mitochondrial respiratory chain complex assembly (GO:0033108)2.73824687
114establishment of protein localization to membrane (GO:0090150)2.73463686
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73343699
116termination of RNA polymerase II transcription (GO:0006369)2.73267172
117energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72748755
118ATP synthesis coupled proton transport (GO:0015986)2.72748755
119positive regulation of ligase activity (GO:0051351)2.72671922
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72297690
121DNA replication-independent nucleosome organization (GO:0034724)2.72222654
122DNA replication-independent nucleosome assembly (GO:0006336)2.72222654
123GMP metabolic process (GO:0046037)2.71308224
124guanosine-containing compound biosynthetic process (GO:1901070)2.67834216
125ncRNA metabolic process (GO:0034660)2.67437841
126aerobic respiration (GO:0009060)2.67195075
127protein localization to chromosome, centromeric region (GO:0071459)2.66092615
128DNA damage response, detection of DNA damage (GO:0042769)2.65783037
129ribonucleoprotein complex assembly (GO:0022618)2.60864351
130regulation of translational fidelity (GO:0006450)2.60746620
131protein neddylation (GO:0045116)2.60570775
132* gene expression (GO:0010467)2.55222945
133histone mRNA metabolic process (GO:0008334)2.53539516
134peptidyl-histidine modification (GO:0018202)2.50504944
135respiratory chain complex IV assembly (GO:0008535)2.50347166
136mitochondrial transport (GO:0006839)2.50284814
137GTP biosynthetic process (GO:0006183)2.49707020
138IMP biosynthetic process (GO:0006188)2.47369564
139regulation of helicase activity (GO:0051095)2.47337933
140ribonucleoprotein complex subunit organization (GO:0071826)2.46905192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87603111
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.56068690
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10009920
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.43028044
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40805671
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.30450427
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.13705823
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12196613
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09174059
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98010377
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95568114
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90260409
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80038818
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78952740
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58417361
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56029998
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.49900225
18XRN2_22483619_ChIP-Seq_HELA_Human2.48920017
19VDR_23849224_ChIP-Seq_CD4+_Human2.44854496
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42605962
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41919745
22DCP1A_22483619_ChIP-Seq_HELA_Human2.22244548
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21182563
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20976479
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09682452
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08934273
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04340963
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03636331
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.01175285
30TTF2_22483619_ChIP-Seq_HELA_Human2.00945031
31GABP_19822575_ChIP-Seq_HepG2_Human1.93870420
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88388658
33ELK1_19687146_ChIP-ChIP_HELA_Human1.86180109
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83374944
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80565641
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64083756
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61052893
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60682294
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59864924
40AR_21909140_ChIP-Seq_LNCAP_Human1.59763018
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59630478
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57334267
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.56450773
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.55396076
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53982242
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52692035
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51926716
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51649172
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.50170902
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49241974
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40025397
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39709032
53* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37437021
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37299734
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36172142
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.35696699
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34680523
58* MYC_22102868_ChIP-Seq_BL_Human1.34550453
59CIITA_25753668_ChIP-Seq_RAJI_Human1.33772047
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31535713
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.31266952
62KDM5A_27292631_Chip-Seq_BREAST_Human1.31218038
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29871876
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.18804424
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18247586
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17721951
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17409257
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15690798
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14637254
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14523781
71* SPI1_23547873_ChIP-Seq_NB4_Human1.14252186
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12929161
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11543050
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10868837
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10868837
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10868837
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07395446
78MYC_18940864_ChIP-ChIP_HL60_Human1.07069646
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.06421146
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06412516
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06164471
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05776155
83TFEB_21752829_ChIP-Seq_HELA_Human1.05031397
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04206942
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04190242
86VDR_21846776_ChIP-Seq_THP-1_Human1.04073543
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02098855
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00891554
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99575946
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98731435
91* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98450920
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98435427
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95878582
94TP63_17297297_ChIP-ChIP_HaCaT_Human0.95483605
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95070993
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94997082
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93283532
98ELF5_23300383_ChIP-Seq_T47D_Human0.90862349
99CHD1_26751641_Chip-Seq_LNCaP_Human0.88009357
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87548357
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82958368
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82487265
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81676055
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81483939
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81184727
106CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80804769
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80728728
108STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79974308
109ZNF263_19887448_ChIP-Seq_K562_Human0.78928078
110SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78672958
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78631493
112MYB_26560356_Chip-Seq_TH2_Human0.77872588
113MAF_26560356_Chip-Seq_TH2_Human0.76094170
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75706674
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73300422
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.71374813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.07464183
2MP0004957_abnormal_blastocyst_morpholog4.21844559
3MP0010094_abnormal_chromosome_stability3.35666397
4MP0003077_abnormal_cell_cycle3.29388394
5MP0003111_abnormal_nucleus_morphology3.27397005
6MP0009379_abnormal_foot_pigmentation3.26833910
7MP0008057_abnormal_DNA_replication2.69009028
8MP0008058_abnormal_DNA_repair2.48634658
9MP0008932_abnormal_embryonic_tissue2.41314094
10MP0008007_abnormal_cellular_replicative2.33555125
11MP0002396_abnormal_hematopoietic_system2.24058028
12MP0000490_abnormal_crypts_of2.12611962
13MP0009333_abnormal_splenocyte_physiolog2.06691736
14MP0008995_early_reproductive_senescence1.98057960
15MP0006292_abnormal_olfactory_placode1.91175589
16MP0003763_abnormal_thymus_physiology1.91073059
17MP0003786_premature_aging1.89926286
18MP0003186_abnormal_redox_activity1.88019978
19MP0010352_gastrointestinal_tract_polyps1.85163312
20MP0001730_embryonic_growth_arrest1.81120204
21MP0000350_abnormal_cell_proliferation1.73212205
22MP0005451_abnormal_body_composition1.69716328
23MP0003718_maternal_effect1.65847098
24MP0002019_abnormal_tumor_incidence1.50819504
25MP0004808_abnormal_hematopoietic_stem1.49284021
26MP0004381_abnormal_hair_follicle1.47987922
27MP0001835_abnormal_antigen_presentation1.47534624
28MP0000858_altered_metastatic_potential1.43222729
29MP0009697_abnormal_copulation1.39864426
30MP0002160_abnormal_reproductive_system1.39061863
31MP0002398_abnormal_bone_marrow1.38945510
32MP0000685_abnormal_immune_system1.36245061
33MP0002132_abnormal_respiratory_system1.34862845
34MP0003806_abnormal_nucleotide_metabolis1.34180230
35MP0002722_abnormal_immune_system1.33046695
36MP0000313_abnormal_cell_death1.32297154
37MP0006054_spinal_hemorrhage1.31299915
38MP0010307_abnormal_tumor_latency1.31259733
39MP0001545_abnormal_hematopoietic_system1.28097718
40MP0005397_hematopoietic_system_phenotyp1.28097718
41MP0002138_abnormal_hepatobiliary_system1.27587604
42MP0000703_abnormal_thymus_morphology1.27455390
43MP0008789_abnormal_olfactory_epithelium1.25626374
44MP0001697_abnormal_embryo_size1.24956795
45MP0001853_heart_inflammation1.24872482
46MP0000689_abnormal_spleen_morphology1.24728333
47MP0002080_prenatal_lethality1.23744451
48MP0006036_abnormal_mitochondrial_physio1.23178102
49MP0003123_paternal_imprinting1.23102842
50MP0004264_abnormal_extraembryonic_tissu1.22689181
51MP0005671_abnormal_response_to1.22562996
52MP0001529_abnormal_vocalization1.21561398
53MP0003436_decreased_susceptibility_to1.18210299
54MP0001800_abnormal_humoral_immune1.18193834
55MP0009785_altered_susceptibility_to1.17674809
56MP0001293_anophthalmia1.17293302
57MP0002166_altered_tumor_susceptibility1.15133187
58MP0002429_abnormal_blood_cell1.14528652
59MP0002277_abnormal_respiratory_mucosa1.14326883
60MP0002405_respiratory_system_inflammati1.13771621
61MP0001672_abnormal_embryogenesis/_devel1.11799547
62MP0005380_embryogenesis_phenotype1.11799547
63MP0003315_abnormal_perineum_morphology1.11188979
64MP0003890_abnormal_embryonic-extraembry1.11080699
65MP0001764_abnormal_homeostasis1.10960385
66MP0000358_abnormal_cell_content/1.09381514
67MP0002420_abnormal_adaptive_immunity1.09003787
68MP0000716_abnormal_immune_system1.08581048
69MP0003567_abnormal_fetal_cardiomyocyte1.08494218
70MP0002006_tumorigenesis1.07847062
71MP0000750_abnormal_muscle_regeneration1.07365685
72MP0001819_abnormal_immune_cell1.06907481
73MP0002452_abnormal_antigen_presenting1.06397188
74MP0005394_taste/olfaction_phenotype1.03002189
75MP0005499_abnormal_olfactory_system1.03002189
76MP0003984_embryonic_growth_retardation1.01986698
77MP0005501_abnormal_skin_physiology1.00961527
78MP0002723_abnormal_immune_serum1.00831316
79MP0005000_abnormal_immune_tolerance1.00725624
80MP0010155_abnormal_intestine_physiology0.99946876
81MP0002148_abnormal_hypersensitivity_rea0.99144615
82MP0002088_abnormal_embryonic_growth/wei0.99128577
83MP0005025_abnormal_response_to0.99066199
84MP0002938_white_spotting0.98926293
85MP0001873_stomach_inflammation0.96895736
86MP0005645_abnormal_hypothalamus_physiol0.96592213
87MP0005360_urolithiasis0.92670991
88MP0005075_abnormal_melanosome_morpholog0.92087400
89MP0002085_abnormal_embryonic_tissue0.90285611
90MP0005023_abnormal_wound_healing0.89813128
91MP0002086_abnormal_extraembryonic_tissu0.89679350
92MP0006035_abnormal_mitochondrial_morpho0.89059133
93MP0001919_abnormal_reproductive_system0.88276425
94MP0005220_abnormal_exocrine_pancreas0.87174199
95MP0002210_abnormal_sex_determination0.84222387
96MP0001666_abnormal_nutrient_absorption0.80352132
97MP0005379_endocrine/exocrine_gland_phen0.78771406
98MP0001145_abnormal_male_reproductive0.78549869
99MP0003698_abnormal_male_reproductive0.77996805
100MP0002009_preneoplasia0.77664265
101MP0008877_abnormal_DNA_methylation0.77439512
102MP0005084_abnormal_gallbladder_morpholo0.76706095
103MP0005636_abnormal_mineral_homeostasis0.75536211
104MP0009672_abnormal_birth_weight0.74925148
105MP0000477_abnormal_intestine_morphology0.74340256
106MP0003941_abnormal_skin_development0.74283833
107MP0003943_abnormal_hepatobiliary_system0.74227390
108MP0002796_impaired_skin_barrier0.74003959
109MP0003448_altered_tumor_morphology0.73364874
110MP0001845_abnormal_inflammatory_respons0.73212089
111MP0004197_abnormal_fetal_growth/weight/0.72658139
112MP0005310_abnormal_salivary_gland0.71896199
113MP0002095_abnormal_skin_pigmentation0.71770974
114MP0002084_abnormal_developmental_patter0.71463444
115MP0004147_increased_porphyrin_level0.71298387
116MP0003866_abnormal_defecation0.70734722
117MP0005408_hypopigmentation0.69774134
118MP0003656_abnormal_erythrocyte_physiolo0.69514621
119MP0001243_abnormal_dermal_layer0.68270543
120MP0001216_abnormal_epidermal_layer0.67364582
121MP0005387_immune_system_phenotype0.67286875
122MP0001790_abnormal_immune_system0.67286875
123MP0005389_reproductive_system_phenotype0.67183082
124MP0003221_abnormal_cardiomyocyte_apopto0.67048190
125MP0003011_delayed_dark_adaptation0.67036074
126MP0002090_abnormal_vision0.66099760
127MP0001542_abnormal_bone_strength0.65845548
128MP0005410_abnormal_fertilization0.65748130
129MP0000465_gastrointestinal_hemorrhage0.65737036
130MP0002163_abnormal_gland_morphology0.65703322
131MP0001929_abnormal_gametogenesis0.65188403
132MP0003724_increased_susceptibility_to0.64975783
133MP0000653_abnormal_sex_gland0.64674088
134MP0000372_irregular_coat_pigmentation0.64346413

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.51851713
2Abnormal number of erythroid precursors (HP:0012131)6.86843010
3Reticulocytopenia (HP:0001896)6.46885611
4Macrocytic anemia (HP:0001972)5.04589652
5Pallor (HP:0000980)4.75913127
6Birth length less than 3rd percentile (HP:0003561)3.67536360
7Oral leukoplakia (HP:0002745)3.49566828
8Aplastic anemia (HP:0001915)3.48308189
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.24057605
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.24057605
11Breast hypoplasia (HP:0003187)3.18283474
12Microretrognathia (HP:0000308)3.11319924
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.08003098
14Rough bone trabeculation (HP:0100670)3.03451523
15Thrombocytosis (HP:0001894)3.02639518
16Acute necrotizing encephalopathy (HP:0006965)3.02498195
17Mitochondrial inheritance (HP:0001427)2.92161044
18Colon cancer (HP:0003003)2.90662569
19Abnormal hemoglobin (HP:0011902)2.87737195
20Abnormality of the anterior horn cell (HP:0006802)2.87173173
21Degeneration of anterior horn cells (HP:0002398)2.87173173
22Hepatocellular necrosis (HP:0001404)2.79237521
23Abnormal mitochondria in muscle tissue (HP:0008316)2.78371147
24Stomatitis (HP:0010280)2.77255717
25Absent thumb (HP:0009777)2.75774895
26Increased CSF lactate (HP:0002490)2.72873265
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66949441
2811 pairs of ribs (HP:0000878)2.63282111
29Increased hepatocellular lipid droplets (HP:0006565)2.63204558
30Exertional dyspnea (HP:0002875)2.63118704
313-Methylglutaconic aciduria (HP:0003535)2.60767783
32Carpal bone hypoplasia (HP:0001498)2.57968159
33Hepatic necrosis (HP:0002605)2.57660919
34Abnormality of the prostate (HP:0008775)2.57584792
35Panhypogammaglobulinemia (HP:0003139)2.56782168
36Increased serum lactate (HP:0002151)2.48489244
37Selective tooth agenesis (HP:0001592)2.44519464
38Lipid accumulation in hepatocytes (HP:0006561)2.41777598
39Cerebral hypomyelination (HP:0006808)2.41756701
40Acute encephalopathy (HP:0006846)2.40695292
41Abnormality of reticulocytes (HP:0004312)2.39878226
42Premature ovarian failure (HP:0008209)2.38642951
43Congenital, generalized hypertrichosis (HP:0004540)2.37257628
44Progressive external ophthalmoplegia (HP:0000590)2.36162318
45Secondary amenorrhea (HP:0000869)2.36057359
46IgM deficiency (HP:0002850)2.35384894
47Abnormality of methionine metabolism (HP:0010901)2.35277789
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34604991
49Sparse eyelashes (HP:0000653)2.31003089
50Progressive macrocephaly (HP:0004481)2.29726607
51Hypoglycemic coma (HP:0001325)2.29281869
52* Trismus (HP:0000211)2.25398077
53Cerebral edema (HP:0002181)2.23801292
54Patellar aplasia (HP:0006443)2.21948287
55Premature graying of hair (HP:0002216)2.21280829
56Progressive muscle weakness (HP:0003323)2.20721525
57Abnormal trabecular bone morphology (HP:0100671)2.20261233
58Poor head control (HP:0002421)2.15422013
59Pancytopenia (HP:0001876)2.13322212
60Aplasia/Hypoplasia of the patella (HP:0006498)2.13236127
61Type I transferrin isoform profile (HP:0003642)2.11328304
62Central scotoma (HP:0000603)2.11066266
63Exercise intolerance (HP:0003546)2.10539253
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09021530
65Abnormality of the preputium (HP:0100587)2.08250767
66Respiratory difficulties (HP:0002880)2.06974355
67Increased intramyocellular lipid droplets (HP:0012240)2.06250409
68Methylmalonic acidemia (HP:0002912)2.05876599
69Hypoglycemic seizures (HP:0002173)2.05774280
70Neoplasm of the pancreas (HP:0002894)2.04942158
71Depressed nasal ridge (HP:0000457)2.04248300
72Increased IgM level (HP:0003496)2.02062947
73Cellular immunodeficiency (HP:0005374)2.01601088
74B lymphocytopenia (HP:0010976)2.01486187
75Respiratory failure (HP:0002878)1.97515893
76Prostate neoplasm (HP:0100787)1.97366006
77Myelodysplasia (HP:0002863)1.97303969
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95167577
79Abnormality of T cell physiology (HP:0011840)1.94089031
80Hypoplasia of the radius (HP:0002984)1.93729230
81Abnormality of renal resorption (HP:0011038)1.93200297
82Petechiae (HP:0000967)1.92646212
83Sensory axonal neuropathy (HP:0003390)1.92412104
84Triphalangeal thumb (HP:0001199)1.91402720
85Muscle fiber atrophy (HP:0100295)1.91195814
86Neutropenia (HP:0001875)1.88843473
87Hypoplasia of the uterus (HP:0000013)1.88828950
88Increased muscle lipid content (HP:0009058)1.88755462
89Pancreatic islet-cell hyperplasia (HP:0004510)1.87990775
90Abnormality of B cell number (HP:0010975)1.87849072
91Lymphoma (HP:0002665)1.86803688
92Lactic acidosis (HP:0003128)1.85681228
93Hyperinsulinemic hypoglycemia (HP:0000825)1.84126965
94* Multiple enchondromatosis (HP:0005701)1.83974482
95Hyperglycinemia (HP:0002154)1.82973171
96Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82751228
97* Cleft eyelid (HP:0000625)1.82289653
98Generalized aminoaciduria (HP:0002909)1.81867937
99Meckel diverticulum (HP:0002245)1.80907217
100Abnormality of T cells (HP:0002843)1.80457232
101Reduced antithrombin III activity (HP:0001976)1.79979821
102Basal cell carcinoma (HP:0002671)1.79804932
103IgG deficiency (HP:0004315)1.79443015
104Septate vagina (HP:0001153)1.78649074
105Elevated erythrocyte sedimentation rate (HP:0003565)1.78514736
106Abnormality of chromosome stability (HP:0003220)1.77965379
107Bone marrow hypocellularity (HP:0005528)1.77912391
108Horseshoe kidney (HP:0000085)1.77749662
109Abnormality of homocysteine metabolism (HP:0010919)1.77738096
110Homocystinuria (HP:0002156)1.77738096
111Renal Fanconi syndrome (HP:0001994)1.77505775
112Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76736887
113Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76558542
114Abnormality of placental membranes (HP:0011409)1.76339836
115Amniotic constriction ring (HP:0009775)1.76339836
116Stenosis of the external auditory canal (HP:0000402)1.75569058
117Optic disc pallor (HP:0000543)1.75375185
118Abnormality of male internal genitalia (HP:0000022)1.75179835
119Nephroblastoma (Wilms tumor) (HP:0002667)1.74739189
120Poikiloderma (HP:0001029)1.72039771
121Entropion (HP:0000621)1.71428217
122Abnormality of the pancreatic islet cells (HP:0006476)1.71405748
123Abnormality of endocrine pancreas physiology (HP:0012093)1.71405748
124Aplasia/hypoplasia of the uterus (HP:0008684)1.70904302
125Chromsome breakage (HP:0040012)1.70792710
126Megaloblastic anemia (HP:0001889)1.70746214
127Abnormality of the ileum (HP:0001549)1.70519772
128Congenital ichthyosiform erythroderma (HP:0007431)1.68468792
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67340037
130Abnormal protein N-linked glycosylation (HP:0012347)1.67340037
131Abnormal protein glycosylation (HP:0012346)1.67340037
132Abnormal glycosylation (HP:0012345)1.67340037
133Methylmalonic aciduria (HP:0012120)1.67205180
134Squamous cell carcinoma (HP:0002860)1.66491744
135Pulmonary fibrosis (HP:0002206)1.66091599
136Severe combined immunodeficiency (HP:0004430)1.65510302
137Abnormality of the heme biosynthetic pathway (HP:0010472)1.65490551
138Thick lower lip vermilion (HP:0000179)1.65087570
139Impaired proprioception (HP:0010831)1.65069513
140Combined immunodeficiency (HP:0005387)1.62923584
141Microvesicular hepatic steatosis (HP:0001414)1.62449527
142Agnosia (HP:0010524)1.60933775
143Type 2 muscle fiber atrophy (HP:0003554)1.59254884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.21280425
2VRK24.52017104
3CDK194.26658456
4BUB14.14651595
5EIF2AK13.49831692
6WEE13.36439874
7PIM22.50778375
8TESK22.50020408
9CDC72.29300674
10EIF2AK32.29070023
11TAF12.23907113
12STK162.22269683
13SRPK12.15153050
14VRK12.08624682
15TLK12.01585826
16TESK11.88583740
17NEK21.87386379
18NUAK11.85440262
19RPS6KB21.83102334
20MST41.73440445
21MAP4K11.62257361
22NME11.59667479
23ACVR1B1.58842401
24LRRK21.53992758
25BRSK21.53858698
26DYRK31.53634532
27PLK41.52944774
28RPS6KA41.52887804
29SMG11.48589166
30AURKB1.47284803
31KDR1.41254221
32TSSK61.40744904
33TNK21.39150593
34PLK11.35125229
35CDK71.34097275
36BMPR1B1.32491309
37PASK1.27447032
38TTK1.25666470
39EPHA21.23687419
40SCYL21.20909713
41MAP3K111.17639561
42TGFBR11.17458340
43STK101.16743797
44ILK1.14353201
45MAP3K101.11350556
46MAP3K81.10146918
47AURKA1.09220947
48FLT31.07275604
49MAPKAPK31.06382031
50PIM11.06035390
51PAK41.04688459
52TRIM281.03223378
53EEF2K1.03070413
54BCKDK1.00328480
55CDK40.96027785
56ZAP700.95405014
57TEC0.92095914
58ATR0.90836972
59NEK10.87582030
60CDK80.87190002
61LIMK10.85041290
62MAP3K30.83792172
63DAPK10.82862888
64ZAK0.82633130
65MAP2K30.82083181
66CHEK20.81776638
67MKNK10.80287301
68FRK0.77810149
69PLK30.76839018
70PKN20.73915944
71MARK30.73811275
72STK30.73452024
73BTK0.71949042
74CSNK2A20.71006211
75PRPF4B0.70758597
76CDK90.70308497
77PAK10.70136164
78CSNK2A10.69053873
79EIF2AK20.67711400
80RPS6KA50.65253552
81STK40.63956419
82IKBKB0.62906426
83ABL20.61338891
84MAP4K20.60958612
85PRKCI0.60118766
86OXSR10.59702088
87NEK90.59449006
88CHEK10.58038095
89BRAF0.56213928
90TYK20.55943785
91MAP3K120.55289562
92TXK0.55183998
93BRSK10.53940750
94MAP2K60.53554031
95BLK0.53261743
96ARAF0.52979005
97PBK0.52944142
98DAPK30.51812665
99IRAK30.51344480
100GRK60.49566969
101MAP3K130.49033405
102JAK30.48500996
103CDK60.47949122
104CSF1R0.47809280
105CDK30.47368278
106CCNB10.44531844
107IRAK40.44484548
108MAP2K20.43594707
109MKNK20.43306248
110TBK10.42825157
111NLK0.41083030
112STK390.40586319
113DYRK20.40353030
114RAF10.39732895
115CDK20.36911061
116WNK30.35504605
117LYN0.34988607
118TAOK20.34624350
119PDK40.34556367
120PDK30.34556367
121ATM0.33995607
122STK240.33167019
123ERN10.33033337
124FGFR10.32483223
125MAPKAPK50.32363701
126CSNK1E0.32290175
127CSNK1G10.31271729
128SYK0.31145654
129CSNK1G30.30701272
130PAK20.30427793
131BRD40.29762864
132RPS6KB10.29371425
133IKBKE0.27530005

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.06068843
2DNA replication_Homo sapiens_hsa030304.00062132
3Proteasome_Homo sapiens_hsa030503.99440668
4* RNA polymerase_Homo sapiens_hsa030203.44952623
5Mismatch repair_Homo sapiens_hsa034303.33022522
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19212981
7Spliceosome_Homo sapiens_hsa030402.88414740
8* Pyrimidine metabolism_Homo sapiens_hsa002402.59032879
9RNA transport_Homo sapiens_hsa030132.54068163
10Homologous recombination_Homo sapiens_hsa034402.41181535
11Base excision repair_Homo sapiens_hsa034102.36195942
12Nucleotide excision repair_Homo sapiens_hsa034202.35587971
13Protein export_Homo sapiens_hsa030601.94818113
14One carbon pool by folate_Homo sapiens_hsa006701.91061514
15Cell cycle_Homo sapiens_hsa041101.82348322
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80319169
17Oxidative phosphorylation_Homo sapiens_hsa001901.73861912
18Parkinsons disease_Homo sapiens_hsa050121.73803741
19Basal transcription factors_Homo sapiens_hsa030221.57389656
20RNA degradation_Homo sapiens_hsa030181.55890680
21p53 signaling pathway_Homo sapiens_hsa041151.47242265
22* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45924466
23Fanconi anemia pathway_Homo sapiens_hsa034601.45072251
24Huntingtons disease_Homo sapiens_hsa050161.44361401
25Non-homologous end-joining_Homo sapiens_hsa034501.44217058
26Sulfur relay system_Homo sapiens_hsa041221.35048056
27Folate biosynthesis_Homo sapiens_hsa007901.28425002
28* Purine metabolism_Homo sapiens_hsa002301.24858888
29Type I diabetes mellitus_Homo sapiens_hsa049401.24524965
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16434421
31* Epstein-Barr virus infection_Homo sapiens_hsa051691.08846224
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07000135
33mRNA surveillance pathway_Homo sapiens_hsa030151.06476176
34Antigen processing and presentation_Homo sapiens_hsa046120.98199891
35Pentose phosphate pathway_Homo sapiens_hsa000300.97989546
36Propanoate metabolism_Homo sapiens_hsa006400.96957223
37Alzheimers disease_Homo sapiens_hsa050100.95148334
38Fatty acid elongation_Homo sapiens_hsa000620.93993370
39Primary immunodeficiency_Homo sapiens_hsa053400.93381861
40Systemic lupus erythematosus_Homo sapiens_hsa053220.91672012
41Regulation of autophagy_Homo sapiens_hsa041400.89504368
42Herpes simplex infection_Homo sapiens_hsa051680.83721015
43Glutathione metabolism_Homo sapiens_hsa004800.83249535
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.82082688
45Legionellosis_Homo sapiens_hsa051340.75613413
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72727266
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.71934300
48Vitamin B6 metabolism_Homo sapiens_hsa007500.70381429
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.67943340
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67321308
51Viral carcinogenesis_Homo sapiens_hsa052030.63740683
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.63553462
53Pyruvate metabolism_Homo sapiens_hsa006200.62176563
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61402186
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55282460
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53561446
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53555157
58Biosynthesis of amino acids_Homo sapiens_hsa012300.53454913
59Thyroid cancer_Homo sapiens_hsa052160.53436286
60Hematopoietic cell lineage_Homo sapiens_hsa046400.52183232
61Measles_Homo sapiens_hsa051620.51393488
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.51173127
63HTLV-I infection_Homo sapiens_hsa051660.50920571
64N-Glycan biosynthesis_Homo sapiens_hsa005100.50356577
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50071818
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49592886
67Allograft rejection_Homo sapiens_hsa053300.49592437
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.49349346
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48850070
70Apoptosis_Homo sapiens_hsa042100.48814491
71Carbon metabolism_Homo sapiens_hsa012000.46029272
72Shigellosis_Homo sapiens_hsa051310.45758993
73Vitamin digestion and absorption_Homo sapiens_hsa049770.43035496
74* Metabolic pathways_Homo sapiens_hsa011000.40580678
75Small cell lung cancer_Homo sapiens_hsa052220.40198864
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40150255
77Asthma_Homo sapiens_hsa053100.40131194
78Arachidonic acid metabolism_Homo sapiens_hsa005900.39599886
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37616690
80Selenocompound metabolism_Homo sapiens_hsa004500.37488294
81Graft-versus-host disease_Homo sapiens_hsa053320.37223078
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36746194
83Fructose and mannose metabolism_Homo sapiens_hsa000510.36389767
84Fat digestion and absorption_Homo sapiens_hsa049750.32771995
85Rheumatoid arthritis_Homo sapiens_hsa053230.32595377
86Ether lipid metabolism_Homo sapiens_hsa005650.32031972
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31755355
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31513051
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30073804
90Steroid biosynthesis_Homo sapiens_hsa001000.29809285
91Other glycan degradation_Homo sapiens_hsa005110.29644867
92Collecting duct acid secretion_Homo sapiens_hsa049660.29354409
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29181175
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29102375
95Peroxisome_Homo sapiens_hsa041460.28892958
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28701029
97Hepatitis B_Homo sapiens_hsa051610.28041675
98Bladder cancer_Homo sapiens_hsa052190.27695322
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27685689
100Oocyte meiosis_Homo sapiens_hsa041140.26617871
101Leishmaniasis_Homo sapiens_hsa051400.26327231
102Butanoate metabolism_Homo sapiens_hsa006500.26321516
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26229653
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24416206
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24401092
106Galactose metabolism_Homo sapiens_hsa000520.24190221
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23749240
108Viral myocarditis_Homo sapiens_hsa054160.23484844
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23422049
110Influenza A_Homo sapiens_hsa051640.22515982
111Linoleic acid metabolism_Homo sapiens_hsa005910.21692048
112Tryptophan metabolism_Homo sapiens_hsa003800.20048923
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19884631
114HIF-1 signaling pathway_Homo sapiens_hsa040660.19719455
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.19623095
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19130681
117Acute myeloid leukemia_Homo sapiens_hsa052210.18963936
118Renin-angiotensin system_Homo sapiens_hsa046140.18744827
119Autoimmune thyroid disease_Homo sapiens_hsa053200.17179015
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16645893
121TGF-beta signaling pathway_Homo sapiens_hsa043500.15843864
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15623086
123Caffeine metabolism_Homo sapiens_hsa002320.15544388
124Cardiac muscle contraction_Homo sapiens_hsa042600.15316906
125MicroRNAs in cancer_Homo sapiens_hsa052060.14471025
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14310961
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.13625374

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