POLR2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.98736975
2Golgi transport vesicle coating (GO:0048200)4.79098600
3COPI coating of Golgi vesicle (GO:0048205)4.79098600
4positive regulation of mitotic sister chromatid separation (GO:1901970)4.63031160
5positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.63031160
6positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.63031160
7DNA replication checkpoint (GO:0000076)4.59408558
8regulation of sister chromatid cohesion (GO:0007063)4.58277450
9maturation of 5.8S rRNA (GO:0000460)4.43219727
10positive regulation of chromosome segregation (GO:0051984)4.41916784
11DNA deamination (GO:0045006)4.25176870
12CENP-A containing nucleosome assembly (GO:0034080)4.25081892
13chromatin remodeling at centromere (GO:0031055)4.18968520
14protein deneddylation (GO:0000338)4.18359147
15proteasome assembly (GO:0043248)4.16119261
16DNA replication initiation (GO:0006270)4.15697421
17non-recombinational repair (GO:0000726)4.13655791
18double-strand break repair via nonhomologous end joining (GO:0006303)4.13655791
19metaphase plate congression (GO:0051310)4.12925916
20DNA strand elongation involved in DNA replication (GO:0006271)4.05756854
21rRNA modification (GO:0000154)3.95832789
22regulation of cellular amino acid metabolic process (GO:0006521)3.93359105
23protein maturation by protein folding (GO:0022417)3.92533521
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.91887100
25telomere maintenance via semi-conservative replication (GO:0032201)3.91714980
26maturation of SSU-rRNA (GO:0030490)3.85428640
27DNA strand elongation (GO:0022616)3.85202998
28L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.83566266
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.79668756
30termination of RNA polymerase III transcription (GO:0006386)3.79668756
31DNA replication-independent nucleosome organization (GO:0034724)3.79378398
32DNA replication-independent nucleosome assembly (GO:0006336)3.79378398
33protein K6-linked ubiquitination (GO:0085020)3.75196951
34cullin deneddylation (GO:0010388)3.75137796
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.72530505
36establishment of chromosome localization (GO:0051303)3.72120872
37attachment of spindle microtubules to kinetochore (GO:0008608)3.70823392
38purine nucleobase biosynthetic process (GO:0009113)3.67974316
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67390151
40telomere maintenance via recombination (GO:0000722)3.65006961
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64746760
42nucleobase biosynthetic process (GO:0046112)3.63594892
43kinetochore assembly (GO:0051382)3.62265166
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.61019295
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.61019295
46tRNA aminoacylation for protein translation (GO:0006418)3.55436154
47mitotic sister chromatid segregation (GO:0000070)3.54830722
48tRNA aminoacylation (GO:0043039)3.51648282
49amino acid activation (GO:0043038)3.51648282
50proline biosynthetic process (GO:0006561)3.51557590
51histone exchange (GO:0043486)3.51190437
52signal transduction involved in cell cycle checkpoint (GO:0072395)3.50708748
53* 7-methylguanosine mRNA capping (GO:0006370)3.50055083
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48379562
55chaperone-mediated protein transport (GO:0072321)3.47317558
56DNA replication-dependent nucleosome assembly (GO:0006335)3.43684098
57DNA replication-dependent nucleosome organization (GO:0034723)3.43684098
58spliceosomal snRNP assembly (GO:0000387)3.43215710
59mitochondrial RNA metabolic process (GO:0000959)3.40458965
60* RNA capping (GO:0036260)3.39946843
61* 7-methylguanosine RNA capping (GO:0009452)3.39946843
62regulation of translational fidelity (GO:0006450)3.39688584
63protein localization to kinetochore (GO:0034501)3.39609912
64kinetochore organization (GO:0051383)3.38965747
65* transcription-coupled nucleotide-excision repair (GO:0006283)3.38688997
66nucleobase-containing small molecule interconversion (GO:0015949)3.38364516
67mitotic recombination (GO:0006312)3.37983681
68rRNA methylation (GO:0031167)3.37526040
69negative regulation of ligase activity (GO:0051352)3.36813226
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36813226
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36454365
72formation of translation preinitiation complex (GO:0001731)3.36151312
73regulation of translational termination (GO:0006449)3.35295035
74regulation of ligase activity (GO:0051340)3.35115466
75ribosome biogenesis (GO:0042254)3.34377103
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32893176
77ribosome assembly (GO:0042255)3.30822454
78L-serine metabolic process (GO:0006563)3.30052658
79mitotic nuclear envelope disassembly (GO:0007077)3.29369594
80ribosomal large subunit biogenesis (GO:0042273)3.27369293
81spindle checkpoint (GO:0031577)3.26338986
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25191465
83regulation of spindle organization (GO:0090224)3.24951425
84rRNA processing (GO:0006364)3.24497725
85telomere maintenance via telomere lengthening (GO:0010833)3.23842682
86regulation of double-strand break repair via homologous recombination (GO:0010569)3.22435066
87mitotic chromosome condensation (GO:0007076)3.21242862
88establishment of viral latency (GO:0019043)3.20632396
89ribonucleoprotein complex biogenesis (GO:0022613)3.20631036
90positive regulation of ligase activity (GO:0051351)3.19934085
91regulation of mitochondrial translation (GO:0070129)3.19197309
92spliceosomal complex assembly (GO:0000245)3.19192466
93protein localization to chromosome, centromeric region (GO:0071459)3.18067461
94folic acid-containing compound biosynthetic process (GO:0009396)3.17351746
95nucleotide-excision repair, DNA gap filling (GO:0006297)3.16887892
96deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16243927
97pteridine-containing compound biosynthetic process (GO:0042559)3.16145144
98establishment of protein localization to mitochondrial membrane (GO:0090151)3.15849069
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13743360
100establishment of integrated proviral latency (GO:0075713)3.13723145
101metallo-sulfur cluster assembly (GO:0031163)3.12898994
102iron-sulfur cluster assembly (GO:0016226)3.12898994
103coenzyme A biosynthetic process (GO:0015937)3.12322056
104rRNA metabolic process (GO:0016072)3.12175344
105prenylation (GO:0097354)3.11788291
106protein prenylation (GO:0018342)3.11788291
107negative regulation of mitotic sister chromatid separation (GO:2000816)3.11435561
108negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11435561
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11435561
110negative regulation of sister chromatid segregation (GO:0033046)3.11435561
111negative regulation of chromosome segregation (GO:0051985)3.10626881
112regulation of ubiquitin-protein transferase activity (GO:0051438)3.08644281
113mitotic spindle checkpoint (GO:0071174)3.07395276
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07267013
115G1/S transition of mitotic cell cycle (GO:0000082)3.07150573
116cell cycle G1/S phase transition (GO:0044843)3.07150573
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06991253
118IMP biosynthetic process (GO:0006188)3.06628404
119protein targeting to mitochondrion (GO:0006626)3.06367613
120mitotic spindle assembly checkpoint (GO:0007094)3.04153395
121ribosomal small subunit assembly (GO:0000028)3.03998698
122L-methionine salvage (GO:0071267)3.03819652
123L-methionine biosynthetic process (GO:0071265)3.03819652
124amino acid salvage (GO:0043102)3.03819652
125transcription from RNA polymerase I promoter (GO:0006360)3.03507585
126tricarboxylic acid cycle (GO:0006099)3.02184072
127* transcription elongation from RNA polymerase II promoter (GO:0006368)3.01557735
128DNA unwinding involved in DNA replication (GO:0006268)3.01183949
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00845694
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00845694
131membrane disassembly (GO:0030397)3.00798222
132nuclear envelope disassembly (GO:0051081)3.00798222
133ribosomal small subunit biogenesis (GO:0042274)3.00062233
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99854732
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99854732
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99854732
137mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99758088
138negative regulation of protein ubiquitination (GO:0031397)2.97156392
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96447530
140pseudouridine synthesis (GO:0001522)2.96198529
141GDP-mannose metabolic process (GO:0019673)2.94043005
142positive regulation of cell cycle arrest (GO:0071158)2.91825687
143COPII vesicle coating (GO:0048208)2.91478790
144negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.86168495
145regulation of cellular amine metabolic process (GO:0033238)2.85162606
146regulation of mammary gland epithelial cell proliferation (GO:0033599)2.84847944
147establishment of protein localization to mitochondrion (GO:0072655)2.79342964
148peptidyl-lysine dimethylation (GO:0018027)2.78388886
149translation (GO:0006412)2.71099523
150negative regulation of Ras GTPase activity (GO:0034261)2.71013580
151IMP metabolic process (GO:0046040)2.70303029
152eosinophil chemotaxis (GO:0048245)2.69909287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.44337093
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.30963794
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.27926589
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.74874119
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.69111113
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.64663773
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47412241
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.46247141
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.37242056
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31496365
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23994878
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.22014125
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04805771
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94400059
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94093222
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.91030511
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83943391
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80889929
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66892811
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52172348
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48497319
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44397498
23* VDR_23849224_ChIP-Seq_CD4+_Human2.42308024
24* XRN2_22483619_ChIP-Seq_HELA_Human2.35899083
25DCP1A_22483619_ChIP-Seq_HELA_Human2.32877615
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32049750
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28721086
28* GABP_19822575_ChIP-Seq_HepG2_Human2.19878273
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12497819
30NANOG_18555785_ChIP-Seq_MESCs_Mouse2.08340922
31AR_21909140_ChIP-Seq_LNCAP_Human2.04056149
32FOXP3_21729870_ChIP-Seq_TREG_Human2.03876591
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.97447296
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97114797
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96052414
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95425538
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.93936588
38TTF2_22483619_ChIP-Seq_HELA_Human1.91794539
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.89815760
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87272862
41ZNF263_19887448_ChIP-Seq_K562_Human1.78082817
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.77564651
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77323718
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74895352
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70397997
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67839175
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67571987
48ELK1_19687146_ChIP-ChIP_HELA_Human1.58128547
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57254926
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55874082
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54215382
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53464377
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52396524
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52364917
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49197104
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45158056
57KDM5A_27292631_Chip-Seq_BREAST_Human1.42474793
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41322685
59MYC_18940864_ChIP-ChIP_HL60_Human1.39897434
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39372303
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37277698
62CIITA_25753668_ChIP-Seq_RAJI_Human1.33254375
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32824152
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32410925
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31589228
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29087343
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25316015
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21712908
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21515011
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20659172
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18798112
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.18275470
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17997147
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16614861
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15246922
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14627119
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12281560
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.11958963
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11642060
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10715884
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10697450
82* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09425825
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08296101
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06610953
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06112934
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05937790
87* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05225527
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03639815
89KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03589755
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02892685
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00706419
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99520311
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98890199
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97887322
95FOXP1_21924763_ChIP-Seq_HESCs_Human0.95670560
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95111400
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95041046
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.94738253
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94733315
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.93365190
101* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92607600
102GATA1_22025678_ChIP-Seq_K562_Human0.91786677
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90632558
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90498526
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90390297
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90339678
107TFEB_21752829_ChIP-Seq_HELA_Human0.87720689
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87350573
109TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84908361
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84666650
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84055301
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82719477
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82196648
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81354816
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80791479
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80272836
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78655631
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.77451523
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77446098
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77041847
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75848139
122POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.71176929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.83755694
2MP0004957_abnormal_blastocyst_morpholog4.54130720
3MP0003111_abnormal_nucleus_morphology4.43357834
4MP0010094_abnormal_chromosome_stability4.28852680
5MP0003077_abnormal_cell_cycle3.90219433
6MP0003718_maternal_effect3.52113929
7MP0003646_muscle_fatigue3.24676547
8MP0008058_abnormal_DNA_repair3.21510046
9MP0003123_paternal_imprinting3.18108894
10MP0008932_abnormal_embryonic_tissue3.02298356
11MP0008877_abnormal_DNA_methylation2.92590624
12MP0002102_abnormal_ear_morphology2.90790093
13MP0008007_abnormal_cellular_replicative2.74071674
14MP0002653_abnormal_ependyma_morphology2.53865542
15MP0008057_abnormal_DNA_replication2.44371566
16MP0006292_abnormal_olfactory_placode2.26998626
17MP0005451_abnormal_body_composition2.24363958
18MP0003786_premature_aging2.17383706
19MP0001730_embryonic_growth_arrest2.10248336
20MP0000350_abnormal_cell_proliferation1.90794147
21MP0001661_extended_life_span1.88007955
22MP0003303_peritoneal_inflammation1.76871904
23MP0009672_abnormal_birth_weight1.75321782
24MP0003315_abnormal_perineum_morphology1.68888360
25MP0001529_abnormal_vocalization1.66817514
26MP0001697_abnormal_embryo_size1.64531746
27MP0010030_abnormal_orbit_morphology1.61711520
28MP0002210_abnormal_sex_determination1.58541481
29MP0003121_genomic_imprinting1.57147339
30MP0000467_abnormal_esophagus_morphology1.52377411
31MP0001293_anophthalmia1.47988661
32MP0003941_abnormal_skin_development1.47516984
33MP0001915_intracranial_hemorrhage1.45669850
34MP0002085_abnormal_embryonic_tissue1.45341765
35MP0005380_embryogenesis_phenotype1.44439893
36MP0001672_abnormal_embryogenesis/_devel1.44439893
37MP0001119_abnormal_female_reproductive1.39363581
38MP0000653_abnormal_sex_gland1.38729910
39MP0001929_abnormal_gametogenesis1.38176056
40MP0005501_abnormal_skin_physiology1.36733805
41MP0006036_abnormal_mitochondrial_physio1.36629513
42MP0002080_prenatal_lethality1.35170927
43MP0000490_abnormal_crypts_of1.34754958
44MP0009697_abnormal_copulation1.30678622
45MP0001145_abnormal_male_reproductive1.30269591
46MP0009333_abnormal_splenocyte_physiolog1.25813931
47MP0003984_embryonic_growth_retardation1.24766050
48MP0000313_abnormal_cell_death1.19910421
49MP0002088_abnormal_embryonic_growth/wei1.19630285
50MP0003186_abnormal_redox_activity1.18665032
51MP0002084_abnormal_developmental_patter1.18490205
52MP0003806_abnormal_nucleotide_metabolis1.18473698
53MP0010234_abnormal_vibrissa_follicle1.15393490
54MP0008260_abnormal_autophagy1.14502748
55MP0002019_abnormal_tumor_incidence1.14016930
56MP0009840_abnormal_foam_cell1.13397403
57MP0004133_heterotaxia1.12319487
58MP0003937_abnormal_limbs/digits/tail_de1.10952255
59MP0005395_other_phenotype1.09765360
60MP0005332_abnormal_amino_acid1.08229897
61MP0002160_abnormal_reproductive_system1.08050944
62MP0006035_abnormal_mitochondrial_morpho1.08035735
63MP0003699_abnormal_female_reproductive1.00369468
64MP0000372_irregular_coat_pigmentation1.00027654
65MP0010352_gastrointestinal_tract_polyps0.98730347
66MP0000358_abnormal_cell_content/0.97994475
67MP0002249_abnormal_larynx_morphology0.97457607
68MP0002396_abnormal_hematopoietic_system0.97281595
69MP0001849_ear_inflammation0.97105045
70MP0001905_abnormal_dopamine_level0.95807180
71MP0005379_endocrine/exocrine_gland_phen0.95104705
72MP0003115_abnormal_respiratory_system0.94051662
73MP0002163_abnormal_gland_morphology0.93801938
74MP0008789_abnormal_olfactory_epithelium0.91992409
75MP0005408_hypopigmentation0.90137003
76MP0005330_cardiomyopathy0.88626381
77MP0005389_reproductive_system_phenotype0.88141821
78MP0000428_abnormal_craniofacial_morphol0.87735270
79MP0002697_abnormal_eye_size0.87576350
80MP0003221_abnormal_cardiomyocyte_apopto0.85818830
81MP0002876_abnormal_thyroid_physiology0.85576204
82MP0003567_abnormal_fetal_cardiomyocyte0.85437240
83MP0003890_abnormal_embryonic-extraembry0.85145304
84MP0002086_abnormal_extraembryonic_tissu0.85116032
85MP0003119_abnormal_digestive_system0.85110614
86MP0001881_abnormal_mammary_gland0.84767999
87MP0001286_abnormal_eye_development0.83071934
88MP0008995_early_reproductive_senescence0.81159553
89MP0002877_abnormal_melanocyte_morpholog0.80964632
90MP0003942_abnormal_urinary_system0.80711542
91MP0002638_abnormal_pupillary_reflex0.79741889
92MP0001986_abnormal_taste_sensitivity0.78924517
93MP0002092_abnormal_eye_morphology0.77932148
94MP0002161_abnormal_fertility/fecundity0.75772666
95MP0000750_abnormal_muscle_regeneration0.74016072
96MP0010307_abnormal_tumor_latency0.73559305
97MP0002127_abnormal_cardiovascular_syste0.73265834
98MP0002132_abnormal_respiratory_system0.72995339
99MP0005384_cellular_phenotype0.72244684
100MP0000678_abnormal_parathyroid_gland0.72085417
101MP0000477_abnormal_intestine_morphology0.71645395
102MP0005266_abnormal_metabolism0.71060693
103MP0001727_abnormal_embryo_implantation0.69073494
104MP0009053_abnormal_anal_canal0.68395259
105MP0002751_abnormal_autonomic_nervous0.68346965
106MP0001919_abnormal_reproductive_system0.67483122
107MP0004084_abnormal_cardiac_muscle0.67115762
108MP0005257_abnormal_intraocular_pressure0.67071098
109MP0005360_urolithiasis0.66852870
110MP0004145_abnormal_muscle_electrophysio0.66339755
111MP0003698_abnormal_male_reproductive0.66255646
112MP0003787_abnormal_imprinting0.65502655
113MP0000049_abnormal_middle_ear0.65383656
114MP0000566_synostosis0.64651119
115MP0004019_abnormal_vitamin_homeostasis0.63982422
116MP0003938_abnormal_ear_development0.63166219
117MP0006072_abnormal_retinal_apoptosis0.62120007
118MP0000534_abnormal_ureter_morphology0.61982138
119MP0005621_abnormal_cell_physiology0.61616225
120MP0006082_CNS_inflammation0.61501615
121MP0001764_abnormal_homeostasis0.61321739
122MP0002111_abnormal_tail_morphology0.59650291
123MP0001664_abnormal_digestion0.59564100
124MP0003566_abnormal_cell_adhesion0.59526749
125MP0008875_abnormal_xenobiotic_pharmacok0.58864497
126MP0000598_abnormal_liver_morphology0.58481280
127MP0005083_abnormal_biliary_tract0.56862426
128MP0005636_abnormal_mineral_homeostasis0.56501540
129MP0004197_abnormal_fetal_growth/weight/0.55589887
130MP0002938_white_spotting0.54869450
131MP0003656_abnormal_erythrocyte_physiolo0.54482800
132MP0002114_abnormal_axial_skeleton0.54265267
133MP0003136_yellow_coat_color0.54242480
134MP0003755_abnormal_palate_morphology0.53999871
135MP0009379_abnormal_foot_pigmentation0.53897302
136MP0004233_abnormal_muscle_weight0.53150318
137MP0003763_abnormal_thymus_physiology0.52716756
138MP0002332_abnormal_exercise_endurance0.52274051
139MP0005499_abnormal_olfactory_system0.50906634
140MP0005394_taste/olfaction_phenotype0.50906634
141MP0002269_muscular_atrophy0.50899399
142MP0000703_abnormal_thymus_morphology0.50330594
143MP0004215_abnormal_myocardial_fiber0.48836241

Predicted human phenotypes

RankGene SetZ-score
1Progressive muscle weakness (HP:0003323)6.08198421
2Abnormality of long-chain fatty-acid metabolism (HP:0010964)6.00569394
3Birth length less than 3rd percentile (HP:0003561)5.72934713
4Breast hypoplasia (HP:0003187)5.17804073
5Cerebral hypomyelination (HP:0006808)4.06211114
6Patellar aplasia (HP:0006443)4.02520288
7Aplasia/Hypoplasia of the patella (HP:0006498)3.80568260
8Acute necrotizing encephalopathy (HP:0006965)3.73184690
9Carpal bone hypoplasia (HP:0001498)3.61648420
10Abnormality of fatty-acid metabolism (HP:0004359)3.55996022
11Long foot (HP:0001833)3.45734019
12Abnormal mitochondria in muscle tissue (HP:0008316)3.42856477
13Mitochondrial inheritance (HP:0001427)3.39692302
14Hepatocellular necrosis (HP:0001404)3.35246992
15Abnormality of the labia minora (HP:0012880)3.28165845
16Chromsome breakage (HP:0040012)3.27450578
17Increased CSF lactate (HP:0002490)3.22849543
18Oral leukoplakia (HP:0002745)3.18675532
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15729662
20Type I transferrin isoform profile (HP:0003642)3.15347744
21Secondary amenorrhea (HP:0000869)3.09003939
22Abnormality of glycolysis (HP:0004366)3.08164074
23Increased serum pyruvate (HP:0003542)3.08164074
24Reticulocytopenia (HP:0001896)3.08135083
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05405764
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05405764
27Duplicated collecting system (HP:0000081)2.98735253
28Rough bone trabeculation (HP:0100670)2.98368696
29Acute encephalopathy (HP:0006846)2.97118086
30Abnormality of the preputium (HP:0100587)2.97045921
31Meckel diverticulum (HP:0002245)2.92559538
32Increased hepatocellular lipid droplets (HP:0006565)2.92380359
33Rhabdomyolysis (HP:0003201)2.91270911
34Aplastic anemia (HP:0001915)2.90614136
35Abnormality of cells of the erythroid lineage (HP:0012130)2.90428435
36Microvesicular hepatic steatosis (HP:0001414)2.86608584
37Progressive macrocephaly (HP:0004481)2.82677461
38Hepatic necrosis (HP:0002605)2.80685365
39Premature ovarian failure (HP:0008209)2.79221577
40Abnormality of the ileum (HP:0001549)2.77985400
41Large for gestational age (HP:0001520)2.77642225
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75760029
43Myoglobinuria (HP:0002913)2.75474626
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.74111979
45Dry hair (HP:0011359)2.73967229
46Abnormal number of erythroid precursors (HP:0012131)2.73405548
47Hypoplastic pelvis (HP:0008839)2.72838499
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.72602494
49Ragged-red muscle fibers (HP:0003200)2.72058770
50Increased serum lactate (HP:0002151)2.71162918
51Absent radius (HP:0003974)2.69740743
52Exertional dyspnea (HP:0002875)2.66923842
53Microretrognathia (HP:0000308)2.65847050
54Flat capital femoral epiphysis (HP:0003370)2.63466465
55Hypoglycemic coma (HP:0001325)2.63284002
56Abnormality of chromosome stability (HP:0003220)2.62142106
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.61899028
58Abnormal glycosylation (HP:0012345)2.60040733
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60040733
60Abnormal protein N-linked glycosylation (HP:0012347)2.60040733
61Abnormal protein glycosylation (HP:0012346)2.60040733
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59613522
63Abnormality of alanine metabolism (HP:0010916)2.59613522
64Hyperalaninemia (HP:0003348)2.59613522
65Hypobetalipoproteinemia (HP:0003563)2.55978859
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55355319
67Absent forearm bone (HP:0003953)2.53413177
68Aplasia involving forearm bones (HP:0009822)2.53413177
69Generalized amyotrophy (HP:0003700)2.52723436
70Degeneration of anterior horn cells (HP:0002398)2.52208723
71Abnormality of the anterior horn cell (HP:0006802)2.52208723
72Irregular epiphyses (HP:0010582)2.47658294
73Hyperinsulinemic hypoglycemia (HP:0000825)2.47517175
74Adrenal hypoplasia (HP:0000835)2.47426290
75Lipid accumulation in hepatocytes (HP:0006561)2.47241678
76Ureteral duplication (HP:0000073)2.44915905
77Supernumerary spleens (HP:0009799)2.44337536
78Horseshoe kidney (HP:0000085)2.42324800
79Epiphyseal stippling (HP:0010655)2.41086275
80Cerebral edema (HP:0002181)2.40577699
81Breast aplasia (HP:0100783)2.37908667
82Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37837800
83CNS hypomyelination (HP:0003429)2.36924275
84Aplasia/Hypoplasia of the breasts (HP:0010311)2.36412508
85Respiratory difficulties (HP:0002880)2.35941240
86Exercise intolerance (HP:0003546)2.35098332
87Abnormal gallbladder physiology (HP:0012438)2.34999857
88Cholecystitis (HP:0001082)2.34999857
89Brushfield spots (HP:0001088)2.34293921
90Small intestinal stenosis (HP:0012848)2.33092715
91Duodenal stenosis (HP:0100867)2.33092715
92Abnormality of the renal collecting system (HP:0004742)2.32161728
93Steatorrhea (HP:0002570)2.32049761
94Reduced subcutaneous adipose tissue (HP:0003758)2.29853931
95Macrocytic anemia (HP:0001972)2.29695905
96Unsteady gait (HP:0002317)2.29651141
97Progressive external ophthalmoplegia (HP:0000590)2.29619901
98Pancreatic fibrosis (HP:0100732)2.29228289
99Abnormality of endocrine pancreas physiology (HP:0012093)2.28992456
100Abnormality of the pancreatic islet cells (HP:0006476)2.28992456
101Hyperammonemia (HP:0001987)2.27209974
102Abnormal ventriculo-arterial connection (HP:0011563)2.26774874
103Transposition of the great arteries (HP:0001669)2.26774874
104Abnormal connection of the cardiac segments (HP:0011545)2.26774874
105Triphalangeal thumb (HP:0001199)2.22157611
106Severe muscular hypotonia (HP:0006829)2.20657055
107Increased muscle lipid content (HP:0009058)2.20419668
108Absent thumb (HP:0009777)2.19116401
109Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18947669
110Pancreatic islet-cell hyperplasia (HP:0004510)2.18205637
111Abnormality of methionine metabolism (HP:0010901)2.17332805
112Type 2 muscle fiber atrophy (HP:0003554)2.16845474
113Respiratory failure (HP:0002878)2.16047831
114Lactic acidosis (HP:0003128)2.15075574
115Muscle fiber atrophy (HP:0100295)2.15044032
116Pancreatic cysts (HP:0001737)2.13847055
117Aplasia/Hypoplasia involving the musculature (HP:0001460)2.13714035
118Myelodysplasia (HP:0002863)2.13241863
119Increased intramyocellular lipid droplets (HP:0012240)2.13165368
120Abnormal trabecular bone morphology (HP:0100671)2.12403696
121Hypoglycemic seizures (HP:0002173)2.12175413
122Prolonged partial thromboplastin time (HP:0003645)2.11321803
123Bone marrow hypocellularity (HP:0005528)2.10946847
124Premature graying of hair (HP:0002216)2.10583659
125Male infertility (HP:0003251)2.10173385
126Sloping forehead (HP:0000340)2.10034673
127Abnormality of the umbilical cord (HP:0010881)2.08882426
128Reduced antithrombin III activity (HP:0001976)2.08859761
129Squamous cell carcinoma (HP:0002860)2.07133820
130Emotional lability (HP:0000712)2.05730223
131Slender long bone (HP:0003100)2.05399390
132Cleft eyelid (HP:0000625)2.05397715
133Multiple enchondromatosis (HP:0005701)2.05389654
1343-Methylglutaconic aciduria (HP:0003535)2.05372423
135Acute lymphatic leukemia (HP:0006721)2.03122758
136Autoamputation (HP:0001218)2.02684011
137Abnormal lung lobation (HP:0002101)2.01637110
138CNS demyelination (HP:0007305)2.01376411
139Selective tooth agenesis (HP:0001592)1.97576672
140Pancytopenia (HP:0001876)1.97575315
141Trismus (HP:0000211)1.96387136
142Renal Fanconi syndrome (HP:0001994)1.95005103
143Postnatal microcephaly (HP:0005484)1.92162345
144Pallor (HP:0000980)1.92056153
145Sparse eyelashes (HP:0000653)1.90303546
146Abnormality of the duodenum (HP:0002246)1.89362511
147Neoplasm of the pancreas (HP:0002894)1.88983411
148Colon cancer (HP:0003003)1.87799046
149Nemaline bodies (HP:0003798)1.87220043
150Shawl scrotum (HP:0000049)1.86515814
151Testicular atrophy (HP:0000029)1.86212331
152Fat malabsorption (HP:0002630)1.85309771
153Symptomatic seizures (HP:0011145)1.84878757
154Neoplasm of the adrenal gland (HP:0100631)1.84830027
155Nausea (HP:0002018)1.84557079
156Medulloblastoma (HP:0002885)1.84393464
157Abnormal umbilical cord blood vessels (HP:0011403)1.84234230
158Single umbilical artery (HP:0001195)1.84234230
159Abnormality of the fetal cardiovascular system (HP:0010948)1.84234230
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.82903359
161Exercise-induced muscle cramps (HP:0003710)1.79735585
162Hypokinesia (HP:0002375)1.79220093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.17621028
2PLK43.59291802
3CDC73.40799223
4TAOK23.39532909
5EIF2AK13.38929775
6WEE13.27421049
7MAP3K32.87462121
8BRAF2.73481705
9MAP2K32.60644805
10TTK2.57438163
11ARAF2.50307274
12STK38L2.29204269
13ACVR1B2.17763010
14SRPK12.12350807
15STK162.10964811
16NEK22.08363814
17NME22.03881789
18PDK22.02250304
19PLK11.97576736
20VRK11.92017202
21TLK11.92004326
22TSSK61.89390188
23LATS21.89033583
24CDK81.88589642
25DYRK21.80528191
26NEK11.80158911
27VRK21.77951085
28TESK21.67032101
29BRSK21.65095130
30SMG11.59134521
31IRAK31.57205844
32PLK31.55946975
33MST41.48840129
34MUSK1.47319348
35RAF11.47073988
36EIF2AK31.46895408
37AURKB1.46120703
38MOS1.45530097
39AURKA1.42028774
40CHEK21.39868075
41MAPKAPK31.34502293
42MAP3K61.32771956
43CCNB11.32430547
44BRSK11.28973606
45DYRK31.27907496
46MKNK21.26619810
47CDK71.15311240
48BMPR21.14810340
49MKNK11.07882717
50NME11.04960431
51MAP3K81.03198626
52ERBB41.02269982
53ATR0.99729178
54RPS6KB20.96470909
55KSR20.91861847
56RPS6KA40.86829189
57JAK30.86104292
58PIM20.85756386
59ABL20.83518181
60PBK0.81599076
61MAP3K120.80311101
62PRKCI0.79410733
63ALK0.77186869
64EEF2K0.77087147
65AKT30.76710230
66CHEK10.76001842
67PAK10.74619282
68MAP3K90.71975010
69TAOK10.70938214
70MELK0.69604580
71PASK0.69471370
72SCYL20.69414281
73FGFR40.69164241
74MAP3K10.68839772
75ICK0.68806186
76TRIM280.68734794
77ZAK0.66826956
78MAP3K110.60784140
79PAK40.59488790
80LIMK10.59436669
81CDK40.58846046
82CSNK2A10.57092273
83EPHA20.57059799
84TAOK30.56789105
85CDK190.56763216
86TRIB30.56032541
87AKT20.55343258
88BCKDK0.54618270
89KDR0.53315938
90MST1R0.53189490
91ATM0.50129637
92LRRK20.49107433
93CLK10.48211329
94PLK20.47878530
95CDK20.46782232
96MAP2K70.46673877
97MYLK0.43581153
98PDK40.43520078
99PDK30.43520078
100CSNK2A20.43492406
101LATS10.43076752
102ILK0.42543389
103MAP3K50.42120864
104DAPK10.41742528
105CDK90.41533336
106KSR10.41277683
107DYRK1A0.40437419
108MAPK130.38949684
109STK100.38423478
110CDK10.37831468
111STK40.37819617
112CSNK1G30.36979501
113EIF2AK20.36874899
114RPS6KA50.36541711
115TAF10.35675457
116MAP2K60.33715851
117CDK11A0.33712559
118CDK180.32491280
119CDK150.32329641
120MET0.31292277
121TGFBR10.30549520
122DAPK30.29577366
123MAPK110.29116180
124CSNK1E0.28214246
125PHKG20.28020219
126PHKG10.28020219
127TESK10.26457789
128CSNK1G10.26215097
129MAP3K100.25465695
130OBSCN0.25453904
131CDK140.25122495
132PINK10.25086148
133FGFR10.23975513
134TTN0.23827491
135PTK20.23290483
136MAP3K20.20465589
137FLT30.20133257
138BMPR1B0.18860874

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.33443185
2* RNA polymerase_Homo sapiens_hsa030203.96544958
3Proteasome_Homo sapiens_hsa030503.90722929
4Mismatch repair_Homo sapiens_hsa034303.72843015
5Ribosome_Homo sapiens_hsa030103.44021407
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40116482
7Homologous recombination_Homo sapiens_hsa034403.06402073
8Nucleotide excision repair_Homo sapiens_hsa034202.96226644
9Cell cycle_Homo sapiens_hsa041102.92093215
10Base excision repair_Homo sapiens_hsa034102.89749569
11RNA transport_Homo sapiens_hsa030132.88088111
12Spliceosome_Homo sapiens_hsa030402.78642099
13* Pyrimidine metabolism_Homo sapiens_hsa002402.63890389
14Basal transcription factors_Homo sapiens_hsa030222.62084060
15Fatty acid elongation_Homo sapiens_hsa000622.45523109
16RNA degradation_Homo sapiens_hsa030182.39776757
17Fanconi anemia pathway_Homo sapiens_hsa034602.20405754
18Oxidative phosphorylation_Homo sapiens_hsa001902.15712922
19Parkinsons disease_Homo sapiens_hsa050121.91433550
20Vitamin B6 metabolism_Homo sapiens_hsa007501.76470737
21One carbon pool by folate_Homo sapiens_hsa006701.75500873
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75487425
23Huntingtons disease_Homo sapiens_hsa050161.73927782
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.66939546
25Non-homologous end-joining_Homo sapiens_hsa034501.62740370
26* Purine metabolism_Homo sapiens_hsa002301.60393230
27Protein export_Homo sapiens_hsa030601.57900293
28p53 signaling pathway_Homo sapiens_hsa041151.46871255
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42468957
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40620668
31Propanoate metabolism_Homo sapiens_hsa006401.37968017
32mRNA surveillance pathway_Homo sapiens_hsa030151.29215124
33Oocyte meiosis_Homo sapiens_hsa041141.27529506
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25298680
35Sulfur metabolism_Homo sapiens_hsa009201.14255181
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13533168
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.13164299
38Folate biosynthesis_Homo sapiens_hsa007901.08230206
39Alzheimers disease_Homo sapiens_hsa050101.07457186
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05308824
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04428107
42Fatty acid metabolism_Homo sapiens_hsa012121.03639038
43* Epstein-Barr virus infection_Homo sapiens_hsa051691.01782592
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01531930
45Selenocompound metabolism_Homo sapiens_hsa004501.00494209
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99121760
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98015155
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93543385
49Arginine biosynthesis_Homo sapiens_hsa002200.91298222
50Butanoate metabolism_Homo sapiens_hsa006500.83128484
51Steroid biosynthesis_Homo sapiens_hsa001000.82867391
52Peroxisome_Homo sapiens_hsa041460.82732152
53Biosynthesis of amino acids_Homo sapiens_hsa012300.82226784
54Fatty acid degradation_Homo sapiens_hsa000710.80393442
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76401319
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75110482
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64815731
58Lysine degradation_Homo sapiens_hsa003100.64541922
59Pentose phosphate pathway_Homo sapiens_hsa000300.63690208
60Regulation of autophagy_Homo sapiens_hsa041400.63535318
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61066375
62Sulfur relay system_Homo sapiens_hsa041220.60972575
63Cardiac muscle contraction_Homo sapiens_hsa042600.60313070
64Glutathione metabolism_Homo sapiens_hsa004800.58276540
65Linoleic acid metabolism_Homo sapiens_hsa005910.57765113
66beta-Alanine metabolism_Homo sapiens_hsa004100.56977642
67Circadian rhythm_Homo sapiens_hsa047100.55143848
68TGF-beta signaling pathway_Homo sapiens_hsa043500.52897179
69Thyroid cancer_Homo sapiens_hsa052160.52453300
70Herpes simplex infection_Homo sapiens_hsa051680.51217362
71Fat digestion and absorption_Homo sapiens_hsa049750.50616944
72Systemic lupus erythematosus_Homo sapiens_hsa053220.50256576
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48565200
74Arachidonic acid metabolism_Homo sapiens_hsa005900.48441793
75Carbon metabolism_Homo sapiens_hsa012000.48230953
76Phenylalanine metabolism_Homo sapiens_hsa003600.47940196
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47264458
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47247827
79Viral carcinogenesis_Homo sapiens_hsa052030.46951324
80* Metabolic pathways_Homo sapiens_hsa011000.45640032
81Vitamin digestion and absorption_Homo sapiens_hsa049770.44164207
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43018709
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41123341
84Tyrosine metabolism_Homo sapiens_hsa003500.40261672
85HTLV-I infection_Homo sapiens_hsa051660.39496698
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.39054283
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38891787
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38458234
89Fructose and mannose metabolism_Homo sapiens_hsa000510.37302889
90Pyruvate metabolism_Homo sapiens_hsa006200.35842775
91Collecting duct acid secretion_Homo sapiens_hsa049660.33833228
92Ether lipid metabolism_Homo sapiens_hsa005650.29628338
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.26936110
94Bladder cancer_Homo sapiens_hsa052190.26821726
95Alcoholism_Homo sapiens_hsa050340.25365216
96Colorectal cancer_Homo sapiens_hsa052100.25083398
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.24042756
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.23141784
99Hippo signaling pathway_Homo sapiens_hsa043900.22510569
100Galactose metabolism_Homo sapiens_hsa000520.22248499
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21953130
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21329580
103Arginine and proline metabolism_Homo sapiens_hsa003300.20571960
104Vibrio cholerae infection_Homo sapiens_hsa051100.20312604
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18592747
106Shigellosis_Homo sapiens_hsa051310.18491501
107MicroRNAs in cancer_Homo sapiens_hsa052060.18132227
108Antigen processing and presentation_Homo sapiens_hsa046120.17967570
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17179141
110Ovarian steroidogenesis_Homo sapiens_hsa049130.17177526
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14257298
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12859535
113Tryptophan metabolism_Homo sapiens_hsa003800.12049618
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12016077
115Starch and sucrose metabolism_Homo sapiens_hsa005000.11064224
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10740777
117Apoptosis_Homo sapiens_hsa042100.09232156
118Other glycan degradation_Homo sapiens_hsa005110.08353781
119Hepatitis B_Homo sapiens_hsa051610.07929690
120Pancreatic cancer_Homo sapiens_hsa052120.07702044
121N-Glycan biosynthesis_Homo sapiens_hsa005100.07412740
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07270752
123Hedgehog signaling pathway_Homo sapiens_hsa043400.06770166
124HIF-1 signaling pathway_Homo sapiens_hsa040660.06586787
125Melanoma_Homo sapiens_hsa052180.06121121
126Tight junction_Homo sapiens_hsa045300.03930678
127Small cell lung cancer_Homo sapiens_hsa052220.03603696
128Legionellosis_Homo sapiens_hsa051340.03514216
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.01556783
130Type I diabetes mellitus_Homo sapiens_hsa049400.01170181
131Rheumatoid arthritis_Homo sapiens_hsa053230.00842386
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.00197438

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