POLR2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.48932741
2DNA strand elongation involved in DNA replication (GO:0006271)4.38738831
3DNA replication checkpoint (GO:0000076)4.33531328
4CENP-A containing nucleosome assembly (GO:0034080)4.26535786
5proteasome assembly (GO:0043248)4.24042785
6DNA strand elongation (GO:0022616)4.19128096
7mitotic sister chromatid segregation (GO:0000070)4.18056449
8DNA replication initiation (GO:0006270)4.16116426
9telomere maintenance via semi-conservative replication (GO:0032201)4.08082639
10chromatin remodeling at centromere (GO:0031055)4.08068422
11ribosomal small subunit assembly (GO:0000028)4.03294538
12purine nucleobase biosynthetic process (GO:0009113)3.95672318
13sister chromatid segregation (GO:0000819)3.95472873
14nucleobase biosynthetic process (GO:0046112)3.93300163
15metaphase plate congression (GO:0051310)3.89041172
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88690594
17maturation of SSU-rRNA (GO:0030490)3.88650311
18formation of translation preinitiation complex (GO:0001731)3.88146935
19kinetochore assembly (GO:0051382)3.87008650
20DNA deamination (GO:0045006)3.86471620
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.83312264
22termination of RNA polymerase III transcription (GO:0006386)3.83312264
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.82912413
24nuclear pore organization (GO:0006999)3.81593303
25nuclear pore complex assembly (GO:0051292)3.80088238
26DNA replication-independent nucleosome assembly (GO:0006336)3.80056302
27DNA replication-independent nucleosome organization (GO:0034724)3.80056302
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.78825138
29somatic hypermutation of immunoglobulin genes (GO:0016446)3.78825138
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77062445
31ribosome biogenesis (GO:0042254)3.76979773
32kinetochore organization (GO:0051383)3.76685062
33telomere maintenance via recombination (GO:0000722)3.75117447
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72721176
35* 7-methylguanosine mRNA capping (GO:0006370)3.72249547
36protein localization to kinetochore (GO:0034501)3.69555497
37protein K6-linked ubiquitination (GO:0085020)3.69145570
38spliceosomal snRNP assembly (GO:0000387)3.69082738
39* RNA capping (GO:0036260)3.66140557
40* 7-methylguanosine RNA capping (GO:0009452)3.66140557
41establishment of chromosome localization (GO:0051303)3.63494109
42ribosome assembly (GO:0042255)3.58325135
43rRNA modification (GO:0000154)3.57975527
44mitotic recombination (GO:0006312)3.55755908
45protein deneddylation (GO:0000338)3.55453872
46negative regulation of ligase activity (GO:0051352)3.54234489
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54234489
48* transcription-coupled nucleotide-excision repair (GO:0006283)3.53223010
49ribonucleoprotein complex biogenesis (GO:0022613)3.51340348
50histone exchange (GO:0043486)3.51101890
51viral mRNA export from host cell nucleus (GO:0046784)3.50920535
52attachment of spindle microtubules to kinetochore (GO:0008608)3.50282437
53mitotic sister chromatid cohesion (GO:0007064)3.48659091
54cullin deneddylation (GO:0010388)3.47471149
55IMP biosynthetic process (GO:0006188)3.46946099
56termination of RNA polymerase I transcription (GO:0006363)3.43339494
57DNA replication-dependent nucleosome assembly (GO:0006335)3.41587119
58DNA replication-dependent nucleosome organization (GO:0034723)3.41587119
59non-recombinational repair (GO:0000726)3.40943596
60double-strand break repair via nonhomologous end joining (GO:0006303)3.40943596
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39734977
62ribosomal large subunit biogenesis (GO:0042273)3.39073005
63mitotic chromosome condensation (GO:0007076)3.38374861
64transcription elongation from RNA polymerase I promoter (GO:0006362)3.35680085
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35677039
66maturation of 5.8S rRNA (GO:0000460)3.35556566
67transcription from RNA polymerase I promoter (GO:0006360)3.32291426
68establishment of integrated proviral latency (GO:0075713)3.32223426
69mitotic nuclear envelope disassembly (GO:0007077)3.31430993
70rRNA processing (GO:0006364)3.31349724
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31316999
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31316999
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31316999
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.30887818
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29991453
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29991453
77DNA unwinding involved in DNA replication (GO:0006268)3.28062295
78telomere maintenance via telomere lengthening (GO:0010833)3.25054364
79signal transduction involved in DNA damage checkpoint (GO:0072422)3.24297701
80signal transduction involved in DNA integrity checkpoint (GO:0072401)3.24297701
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23106819
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.22593186
83spliceosomal complex assembly (GO:0000245)3.22243414
84DNA ligation (GO:0006266)3.22235112
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.21778477
86regulation of centriole replication (GO:0046599)3.21708320
87protein localization to chromosome, centromeric region (GO:0071459)3.21276801
88histone H2A acetylation (GO:0043968)3.20450612
89rRNA metabolic process (GO:0016072)3.19714139
90G1/S transition of mitotic cell cycle (GO:0000082)3.17370233
91cell cycle G1/S phase transition (GO:0044843)3.17370233
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17110909
93regulation of mitotic spindle checkpoint (GO:1903504)3.17110909
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16970885
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16540924
96regulation of mitochondrial translation (GO:0070129)3.16387271
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15245810
98positive regulation of ligase activity (GO:0051351)3.14787644
99folic acid-containing compound biosynthetic process (GO:0009396)3.14539449
100* transcription elongation from RNA polymerase II promoter (GO:0006368)3.12397153
101regulation of double-strand break repair via homologous recombination (GO:0010569)3.11620122
102ribosomal small subunit biogenesis (GO:0042274)3.11012266
103regulation of cellular amino acid metabolic process (GO:0006521)3.09270051
104mitotic spindle checkpoint (GO:0071174)3.08401383
105regulation of centrosome cycle (GO:0046605)3.07293792
106pseudouridine synthesis (GO:0001522)3.06409865
107spindle checkpoint (GO:0031577)3.05958754
108regulation of chromosome segregation (GO:0051983)3.05346385
109DNA double-strand break processing (GO:0000729)3.03833953
110mitochondrial RNA metabolic process (GO:0000959)3.03728891
111DNA catabolic process, exonucleolytic (GO:0000738)3.03728374
112negative regulation of DNA-dependent DNA replication (GO:2000104)3.02856829
113transcription initiation from RNA polymerase I promoter (GO:0006361)3.02632998
114replication fork processing (GO:0031297)3.02632379
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01990985
116regulation of nuclear cell cycle DNA replication (GO:0033262)3.01694352
117regulation of ubiquitin-protein transferase activity (GO:0051438)3.01374701
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01143266
119nuclear envelope disassembly (GO:0051081)3.00693748
120membrane disassembly (GO:0030397)3.00693748
121amino acid activation (GO:0043038)3.00654540
122tRNA aminoacylation (GO:0043039)3.00654540
123negative regulation of mitotic sister chromatid separation (GO:2000816)3.00397577
124negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00397577
125negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00397577
126negative regulation of sister chromatid segregation (GO:0033046)3.00397577
127regulation of DNA endoreduplication (GO:0032875)2.99361719
128DNA-templated transcription, termination (GO:0006353)2.99298401
129IMP metabolic process (GO:0046040)2.98887494
130negative regulation of chromosome segregation (GO:0051985)2.98079088
131* DNA-templated transcription, elongation (GO:0006354)2.97809331
132establishment of protein localization to mitochondrial membrane (GO:0090151)2.97787439
133tRNA aminoacylation for protein translation (GO:0006418)2.97181950
134establishment of viral latency (GO:0019043)2.97030013
135meiotic chromosome segregation (GO:0045132)2.94906607
136regulation of translational fidelity (GO:0006450)2.93669257
137positive regulation of chromosome segregation (GO:0051984)2.90115451
138somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89707836
139isotype switching (GO:0045190)2.89707836
140somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89707836
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88295737
142regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88295737
143DNA topological change (GO:0006265)2.87551088
144somatic recombination of immunoglobulin gene segments (GO:0016447)2.87306680
145mitotic spindle assembly checkpoint (GO:0007094)2.87181749
146L-serine metabolic process (GO:0006563)2.87050140
147chromosome segregation (GO:0007059)2.85566911
148spindle assembly checkpoint (GO:0071173)2.84273011
149regulation of mitotic sister chromatid segregation (GO:0033047)2.83470264
150regulation of sister chromatid segregation (GO:0033045)2.83470264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.09078787
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43077963
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.20769278
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.72090764
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.69752094
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.54583551
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49116606
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.46748093
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.34510913
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.20471468
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20280555
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.16543156
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94874578
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93957591
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91889684
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88509017
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84229775
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83356305
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.79199738
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61155618
21VDR_23849224_ChIP-Seq_CD4+_Human2.50077238
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44522309
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38541174
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38531936
25XRN2_22483619_ChIP-Seq_HELA_Human2.37349990
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20903269
27AR_21909140_ChIP-Seq_LNCAP_Human2.18763176
28DCP1A_22483619_ChIP-Seq_HELA_Human2.16583023
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16307964
30FOXP3_21729870_ChIP-Seq_TREG_Human2.10886493
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.10466052
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10172070
33GABP_19822575_ChIP-Seq_HepG2_Human2.08586947
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04565038
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04390656
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98325572
37TTF2_22483619_ChIP-Seq_HELA_Human1.94788703
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94305122
39ELK1_19687146_ChIP-ChIP_HELA_Human1.91297271
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.87974214
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86457141
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.84798005
43* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79333714
44* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74817337
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74391210
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74296450
47ZNF274_21170338_ChIP-Seq_K562_Hela1.71423180
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.68121318
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67549305
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67107004
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63901170
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62937652
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60929388
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58195199
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53917551
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.51106315
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.50736615
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49397604
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40572125
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38624843
61EWS_26573619_Chip-Seq_HEK293_Human1.37431638
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35213339
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30720071
64CIITA_25753668_ChIP-Seq_RAJI_Human1.29369179
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28103492
66KDM5A_27292631_Chip-Seq_BREAST_Human1.24897900
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24256819
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23564479
69* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22776115
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22118761
71* MYC_18940864_ChIP-ChIP_HL60_Human1.19120067
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18443047
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18114973
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.16935708
75IRF1_19129219_ChIP-ChIP_H3396_Human1.15780105
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12494307
77FUS_26573619_Chip-Seq_HEK293_Human1.11912215
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11070896
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.09910520
80VDR_22108803_ChIP-Seq_LS180_Human1.09593354
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.09354693
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08784582
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06693657
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.05115955
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03466192
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01272861
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99493541
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99339414
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99258600
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97607227
91IGF1R_20145208_ChIP-Seq_DFB_Human0.93632558
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91326953
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90728656
94TFEB_21752829_ChIP-Seq_HELA_Human0.90171447
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89775911
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88263583
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87079576
98* NANOG_21062744_ChIP-ChIP_HESCs_Human0.86074772
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84518566
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.83795404
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83529254
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82839864
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79960618
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79946741
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79355098
106SPI1_23547873_ChIP-Seq_NB4_Human0.79038345
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77838163
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77435711
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76568815
110TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76206020
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75387324
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74267794
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72115438
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.71741405
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.68441939
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.67320673
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.62062498
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.61706434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.18275065
2MP0010094_abnormal_chromosome_stability4.35632260
3MP0004957_abnormal_blastocyst_morpholog4.23489470
4MP0003077_abnormal_cell_cycle3.89922812
5MP0003111_abnormal_nucleus_morphology3.89366023
6MP0008058_abnormal_DNA_repair3.67235485
7MP0008057_abnormal_DNA_replication3.61718938
8MP0003718_maternal_effect2.84975313
9MP0008932_abnormal_embryonic_tissue2.84563159
10MP0008007_abnormal_cellular_replicative2.84205769
11MP0008877_abnormal_DNA_methylation2.50470472
12MP0003123_paternal_imprinting2.44591992
13MP0006292_abnormal_olfactory_placode2.39192994
14MP0000350_abnormal_cell_proliferation1.92927488
15MP0003786_premature_aging1.88757538
16MP0002132_abnormal_respiratory_system1.88596820
17MP0001730_embryonic_growth_arrest1.87289076
18MP0004133_heterotaxia1.83530487
19MP0003121_genomic_imprinting1.79790870
20MP0002396_abnormal_hematopoietic_system1.78085107
21MP0008789_abnormal_olfactory_epithelium1.75953889
22MP0003315_abnormal_perineum_morphology1.75348005
23MP0010030_abnormal_orbit_morphology1.54799196
24MP0002210_abnormal_sex_determination1.47344091
25MP0001697_abnormal_embryo_size1.44703685
26MP0005380_embryogenesis_phenotype1.42275164
27MP0001672_abnormal_embryogenesis/_devel1.42275164
28MP0000490_abnormal_crypts_of1.37988967
29MP0002102_abnormal_ear_morphology1.35851236
30MP0002938_white_spotting1.33840502
31MP0002085_abnormal_embryonic_tissue1.33152278
32MP0006072_abnormal_retinal_apoptosis1.27580233
33MP0002080_prenatal_lethality1.26799715
34MP0005499_abnormal_olfactory_system1.26345790
35MP0005394_taste/olfaction_phenotype1.26345790
36MP0000313_abnormal_cell_death1.22836586
37MP0001293_anophthalmia1.21419680
38MP0001529_abnormal_vocalization1.20928601
39MP0003806_abnormal_nucleotide_metabolis1.20837015
40MP0002084_abnormal_developmental_patter1.19813521
41MP0003890_abnormal_embryonic-extraembry1.19702822
42MP0003984_embryonic_growth_retardation1.19450454
43MP0001145_abnormal_male_reproductive1.18240584
44MP0003937_abnormal_limbs/digits/tail_de1.17184404
45MP0000653_abnormal_sex_gland1.15419351
46MP0001119_abnormal_female_reproductive1.14985769
47MP0002088_abnormal_embryonic_growth/wei1.14866961
48MP0002277_abnormal_respiratory_mucosa1.13858030
49MP0002019_abnormal_tumor_incidence1.13423748
50MP0003186_abnormal_redox_activity1.13421342
51MP0001929_abnormal_gametogenesis1.12791894
52MP0004808_abnormal_hematopoietic_stem1.10704504
53MP0000049_abnormal_middle_ear1.07463399
54MP0009333_abnormal_splenocyte_physiolog1.06615222
55MP0009672_abnormal_birth_weight1.06390320
56MP0002653_abnormal_ependyma_morphology1.02339556
57MP0009697_abnormal_copulation1.01285883
58MP0004233_abnormal_muscle_weight1.00394658
59MP0001188_hyperpigmentation0.99309184
60MP0003119_abnormal_digestive_system0.98899837
61MP0002160_abnormal_reproductive_system0.94950779
62MP0005253_abnormal_eye_physiology0.94560932
63MP0002697_abnormal_eye_size0.92689802
64MP0001346_abnormal_lacrimal_gland0.92136248
65MP0002111_abnormal_tail_morphology0.91276430
66MP0003698_abnormal_male_reproductive0.91180585
67MP0003567_abnormal_fetal_cardiomyocyte0.89698973
68MP0005408_hypopigmentation0.89061720
69MP0004197_abnormal_fetal_growth/weight/0.88936972
70MP0003941_abnormal_skin_development0.88682433
71MP0005389_reproductive_system_phenotype0.88468746
72MP0003763_abnormal_thymus_physiology0.87859388
73MP0005084_abnormal_gallbladder_morpholo0.87102102
74MP0010307_abnormal_tumor_latency0.83537187
75MP0008260_abnormal_autophagy0.82369929
76MP0005379_endocrine/exocrine_gland_phen0.82333858
77MP0005187_abnormal_penis_morphology0.82238982
78MP0002086_abnormal_extraembryonic_tissu0.81696313
79MP0005377_hearing/vestibular/ear_phenot0.80903997
80MP0003878_abnormal_ear_physiology0.80903997
81MP0000647_abnormal_sebaceous_gland0.80810917
82MP0000358_abnormal_cell_content/0.79902472
83MP0001286_abnormal_eye_development0.79536484
84MP0003861_abnormal_nervous_system0.78695584
85MP0002638_abnormal_pupillary_reflex0.78307957
86MP0002233_abnormal_nose_morphology0.77733769
87MP0003943_abnormal_hepatobiliary_system0.77598028
88MP0009703_decreased_birth_body0.76459230
89MP0005391_vision/eye_phenotype0.76425304
90MP0001324_abnormal_eye_pigmentation0.76136083
91MP0008995_early_reproductive_senescence0.75689455
92MP0005395_other_phenotype0.75563759
93MP0009250_abnormal_appendicular_skeleto0.75042573
94MP0005220_abnormal_exocrine_pancreas0.73512855
95MP0001905_abnormal_dopamine_level0.73246948
96MP0000703_abnormal_thymus_morphology0.73172470
97MP0003122_maternal_imprinting0.72601452
98MP0003136_yellow_coat_color0.72543405
99MP0005367_renal/urinary_system_phenotyp0.72287952
100MP0000516_abnormal_urinary_system0.72287952
101MP0003938_abnormal_ear_development0.71014494
102MP0001727_abnormal_embryo_implantation0.69857068
103MP0006035_abnormal_mitochondrial_morpho0.69830284
104MP0003221_abnormal_cardiomyocyte_apopto0.69699537
105MP0002398_abnormal_bone_marrow0.69281281
106MP0003755_abnormal_palate_morphology0.68921659
107MP0002234_abnormal_pharynx_morphology0.68720180
108MP0002009_preneoplasia0.68367072
109MP0002161_abnormal_fertility/fecundity0.67573423
110MP0003646_muscle_fatigue0.67519245
111MP0003942_abnormal_urinary_system0.67131329
112MP0000689_abnormal_spleen_morphology0.66630903
113MP0000566_synostosis0.66618425
114MP0003787_abnormal_imprinting0.66575353
115MP0006036_abnormal_mitochondrial_physio0.65883641
116MP0000631_abnormal_neuroendocrine_gland0.65865405
117MP0001919_abnormal_reproductive_system0.65823434
118MP0002722_abnormal_immune_system0.65710569
119MP0002095_abnormal_skin_pigmentation0.65590407
120MP0005384_cellular_phenotype0.65167451
121MP0009379_abnormal_foot_pigmentation0.64595801
122MP0003699_abnormal_female_reproductive0.64280352
123MP0002751_abnormal_autonomic_nervous0.63236674
124MP0001299_abnormal_eye_distance/0.62282209
125MP0001485_abnormal_pinna_reflex0.62281513
126MP0001661_extended_life_span0.62270358
127MP0000372_irregular_coat_pigmentation0.61888089
128MP0002163_abnormal_gland_morphology0.61239355
129MP0000678_abnormal_parathyroid_gland0.60877379
130MP0010352_gastrointestinal_tract_polyps0.60740994
131MP0000858_altered_metastatic_potential0.58967144

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.25916780
2Breast hypoplasia (HP:0003187)4.10635895
3Abnormality of the anterior horn cell (HP:0006802)3.57121751
4Degeneration of anterior horn cells (HP:0002398)3.57121751
5Patellar aplasia (HP:0006443)3.48236586
6Carpal bone hypoplasia (HP:0001498)3.31444642
7Cerebral hypomyelination (HP:0006808)3.31206255
8Aplasia/Hypoplasia of the patella (HP:0006498)3.30568788
9Abnormality of cells of the erythroid lineage (HP:0012130)3.14817808
10Rough bone trabeculation (HP:0100670)3.14678960
11Stenosis of the external auditory canal (HP:0000402)3.14611174
12Abnormal number of erythroid precursors (HP:0012131)3.13778656
13Oral leukoplakia (HP:0002745)3.07047345
14Abnormal lung lobation (HP:0002101)2.95707827
15Aplastic anemia (HP:0001915)2.94717425
16Microretrognathia (HP:0000308)2.88755837
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83339793
18Chromsome breakage (HP:0040012)2.83195718
19Reticulocytopenia (HP:0001896)2.82016073
20Abnormality of the labia minora (HP:0012880)2.78981852
21Colon cancer (HP:0003003)2.75215043
22Abnormality of glycolysis (HP:0004366)2.69331855
23Increased serum pyruvate (HP:0003542)2.69331855
24Meckel diverticulum (HP:0002245)2.66759426
25Microvesicular hepatic steatosis (HP:0001414)2.64782794
26Glossoptosis (HP:0000162)2.64694418
27Irregular epiphyses (HP:0010582)2.62783632
28Abnormality of the preputium (HP:0100587)2.62413190
29Abnormality of the ileum (HP:0001549)2.53636156
30Facial hemangioma (HP:0000329)2.53590869
31Abnormality of the carotid arteries (HP:0005344)2.53205630
32Ependymoma (HP:0002888)2.46493396
33Ectopic kidney (HP:0000086)2.42529218
34Abnormal trabecular bone morphology (HP:0100671)2.40933171
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.39762145
36Absent radius (HP:0003974)2.39029210
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38455132
38Acute encephalopathy (HP:0006846)2.37219312
39Type I transferrin isoform profile (HP:0003642)2.34135443
40Pancreatic cysts (HP:0001737)2.33579397
41Clubbing of toes (HP:0100760)2.32614704
42Duodenal stenosis (HP:0100867)2.32082370
43Small intestinal stenosis (HP:0012848)2.32082370
44Premature graying of hair (HP:0002216)2.27810828
45Multiple enchondromatosis (HP:0005701)2.26230840
46Selective tooth agenesis (HP:0001592)2.25580239
47Long clavicles (HP:0000890)2.25116178
48Volvulus (HP:0002580)2.24070516
49Abnormality of chromosome stability (HP:0003220)2.23800010
50Aplasia involving forearm bones (HP:0009822)2.23786334
51Absent forearm bone (HP:0003953)2.23786334
52Supernumerary spleens (HP:0009799)2.22518860
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.20935135
54Increased hepatocellular lipid droplets (HP:0006565)2.18369448
55Myelodysplasia (HP:0002863)2.17663245
56Increased nuchal translucency (HP:0010880)2.13053101
57Bone marrow hypocellularity (HP:0005528)2.11786261
58Type 2 muscle fiber atrophy (HP:0003554)2.11582422
59Lipid accumulation in hepatocytes (HP:0006561)2.10735381
60Sloping forehead (HP:0000340)2.10696008
61Secondary amenorrhea (HP:0000869)2.09453401
62Muscle fiber atrophy (HP:0100295)2.08543139
63Pendular nystagmus (HP:0012043)2.08219231
64Trismus (HP:0000211)2.07613544
65Medulloblastoma (HP:0002885)2.07224163
66Hyperglycinemia (HP:0002154)2.04283202
67Hypoplasia of the pons (HP:0012110)2.04002327
68Nephroblastoma (Wilms tumor) (HP:0002667)2.01187481
69Horseshoe kidney (HP:0000085)2.00453609
70Abnormal mitochondria in muscle tissue (HP:0008316)2.00329586
7111 pairs of ribs (HP:0000878)1.99440292
72Absent thumb (HP:0009777)1.98482342
73Atresia of the external auditory canal (HP:0000413)1.97905750
74Bifid tongue (HP:0010297)1.97417227
75Abnormality of the pons (HP:0007361)1.97414639
76Acute necrotizing encephalopathy (HP:0006965)1.97355158
77Macrocytic anemia (HP:0001972)1.97180777
78Cortical dysplasia (HP:0002539)1.96974356
79Premature ovarian failure (HP:0008209)1.96604263
80Cleft eyelid (HP:0000625)1.94994476
81Atrophy/Degeneration involving motor neurons (HP:0007373)1.94661178
82Neoplasm of the adrenal cortex (HP:0100641)1.94500090
83Fibular aplasia (HP:0002990)1.93256589
84Increased serum lactate (HP:0002151)1.92486969
85Abnormality of alanine metabolism (HP:0010916)1.92466725
86Hyperalaninemia (HP:0003348)1.92466725
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92466725
88Cellular immunodeficiency (HP:0005374)1.92300678
89Hepatocellular necrosis (HP:0001404)1.92186069
90Embryonal renal neoplasm (HP:0011794)1.91571382
91Short thumb (HP:0009778)1.90685011
92Optic nerve coloboma (HP:0000588)1.90099061
93Mitochondrial inheritance (HP:0001427)1.89949316
94Impulsivity (HP:0100710)1.89385613
95CNS hypomyelination (HP:0003429)1.89330253
96Glioma (HP:0009733)1.87611984
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87456164
98Tracheoesophageal fistula (HP:0002575)1.86991752
99Abnormality of the duodenum (HP:0002246)1.86680251
100Pallor (HP:0000980)1.86636647
101Duplicated collecting system (HP:0000081)1.85797188
102Abnormality of DNA repair (HP:0003254)1.85751533
103Triphalangeal thumb (HP:0001199)1.85648696
104Spinal muscular atrophy (HP:0007269)1.84955157
105Pancreatic islet-cell hyperplasia (HP:0004510)1.83811580
106Poor head control (HP:0002421)1.83643538
107Progressive macrocephaly (HP:0004481)1.83159248
108Abnormal number of incisors (HP:0011064)1.83101887
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83077253
110Abnormal protein N-linked glycosylation (HP:0012347)1.83077253
111Abnormal protein glycosylation (HP:0012346)1.83077253
112Abnormal glycosylation (HP:0012345)1.83077253
113Microtia (HP:0008551)1.81857205
114Increased CSF lactate (HP:0002490)1.81680602
115Dandy-Walker malformation (HP:0001305)1.80667379
116Facial cleft (HP:0002006)1.80352590
117Neoplasm of the pancreas (HP:0002894)1.79944578
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79760491
119Short 1st metacarpal (HP:0010034)1.79281306
120Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.79281306
121Breast aplasia (HP:0100783)1.78808502
122Adrenal hypoplasia (HP:0000835)1.78181629
123Pancreatic fibrosis (HP:0100732)1.77998075
124Capillary hemangiomas (HP:0005306)1.77746654
125Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77491728
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76808389
127Neoplasm of the adrenal gland (HP:0100631)1.76440458
128Prominent metopic ridge (HP:0005487)1.73928448
129Reduced antithrombin III activity (HP:0001976)1.73807605
130Lissencephaly (HP:0001339)1.72909451
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72809093
132Absent epiphyses (HP:0010577)1.72809093
133Cerebral edema (HP:0002181)1.72164534
134Aplasia/Hypoplasia of the breasts (HP:0010311)1.72073231
135Postnatal microcephaly (HP:0005484)1.71806203
136Agnosia (HP:0010524)1.71062414
137Neoplasm of the colon (HP:0100273)1.70143340
138Abnormality of the metopic suture (HP:0005556)1.70121780
139Progressive muscle weakness (HP:0003323)1.69307475
140Hepatic necrosis (HP:0002605)1.67338323
141Abnormality of serum amino acid levels (HP:0003112)1.65689254
142Lactic acidosis (HP:0003128)1.64233166
143Preaxial hand polydactyly (HP:0001177)1.63719074
144Abnormality of the astrocytes (HP:0100707)1.63389540
145Astrocytoma (HP:0009592)1.63389540
146Rhabdomyosarcoma (HP:0002859)1.62012481
147Hyperglycinuria (HP:0003108)1.60926773
148Cafe-au-lait spot (HP:0000957)1.60786518
149Molar tooth sign on MRI (HP:0002419)1.59358219
150Abnormality of midbrain morphology (HP:0002418)1.59358219
151Abnormality of the renal collecting system (HP:0004742)1.59301811
152Intestinal atresia (HP:0011100)1.58497388
153Abnormality of methionine metabolism (HP:0010901)1.58372025
154Pancytopenia (HP:0001876)1.58338289
155Abnormality of glycine metabolism (HP:0010895)1.57663772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.02898606
2WEE13.67900882
3CDC73.20324203
4EIF2AK13.17267145
5PLK43.03703512
6SRPK12.95044139
7TRIM282.93407350
8STK162.87591656
9VRK12.76654918
10VRK22.66518787
11TTK2.25079016
12TSSK62.20101374
13MKNK12.16020798
14EIF2AK32.15877059
15ACVR1B2.11889812
16BRSK22.09983272
17PLK32.09527433
18PLK11.99727049
19NME21.72489715
20TAF11.71868034
21ZAK1.65313238
22TESK21.64900583
23NEK21.64639296
24DYRK21.59084398
25PIM21.57874929
26AURKB1.54759628
27DYRK31.54591467
28CDK71.50254900
29MKNK21.45007839
30CHEK21.43175209
31STK38L1.42995899
32CDK81.42748468
33PBK1.42465775
34ATR1.41342319
35CCNB11.40883158
36WNK31.39050368
37PASK1.33961438
38AURKA1.29429325
39NEK11.28965097
40BRSK11.26831908
41BCKDK1.13475361
42EPHA21.11684833
43EIF2AK21.10147708
44RPS6KB21.07113724
45STK101.06664953
46CHEK11.03307522
47NME11.02217626
48FRK1.01220011
49MST41.01046772
50STK40.98856223
51BRAF0.98622950
52TLK10.97194034
53RPS6KA40.93721030
54TNIK0.93334024
55TGFBR10.91560604
56LATS20.87623376
57MAP3K80.87619127
58MAP4K20.78765278
59MAP3K40.78554041
60CSNK1G20.77809385
61BMPR20.77700451
62IRAK40.77250165
63PAK40.77052830
64CSNK2A10.76953778
65CSNK1A1L0.76516135
66LIMK10.70860336
67ARAF0.70550489
68PIM10.69152604
69ATM0.68412178
70PINK10.68017588
71TXK0.66329650
72BCR0.66070295
73CDK20.65550100
74NEK60.65160581
75MELK0.64696242
76TESK10.64292724
77STK240.64015088
78CSNK2A20.63863123
79CLK10.62123760
80ALK0.61886187
81PRKCI0.61209217
82CDK40.60973398
83PAK10.60710365
84ERBB30.60657111
85MAP2K70.59213202
86ERBB40.57313377
87RPS6KA50.57029772
88MAP3K100.54002687
89CDK10.53595419
90KDR0.50052542
91INSRR0.46187818
92ABL20.46128843
93MAPK130.45636864
94STK30.44910569
95STK390.44253339
96ILK0.44200273
97MAP3K110.44171946
98CSNK1G30.43835984
99SIK30.43180408
100MOS0.43053569
101CDK120.41159737
102PRKDC0.40316685
103DAPK10.40270431
104GRK10.40001891
105BRD40.39071121
106FGFR10.38506676
107MAP4K10.36939851
108WNK40.34822907
109AKT20.34561826
110YES10.34167763
111CDK60.34131718
112TAOK20.34075493
113SMG10.33936492
114SCYL20.33343454
115MAP3K60.33037349
116PNCK0.32075352
117CHUK0.31389861
118CSNK1D0.30196029
119RAF10.29676191
120CDK90.29563849
121CDK180.29035341
122CDK140.28715837
123CSNK1G10.27623493
124BMPR1B0.27620321
125NUAK10.25328583
126KSR10.24354361
127MINK10.24326300
128MAPKAPK50.24306226
129PLK20.23003936
130CDK30.22030823
131RPS6KB10.21445776
132CSNK1E0.21034453
133LATS10.19218154
134MAPKAPK20.17128907

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44607936
2Proteasome_Homo sapiens_hsa030504.16937324
3* RNA polymerase_Homo sapiens_hsa030204.02455451
4Mismatch repair_Homo sapiens_hsa034303.78173219
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66292314
6Spliceosome_Homo sapiens_hsa030403.40702058
7Ribosome_Homo sapiens_hsa030103.40059042
8RNA transport_Homo sapiens_hsa030132.99954835
9Homologous recombination_Homo sapiens_hsa034402.97178726
10Base excision repair_Homo sapiens_hsa034102.96801348
11Nucleotide excision repair_Homo sapiens_hsa034202.84130279
12* Pyrimidine metabolism_Homo sapiens_hsa002402.69337978
13Cell cycle_Homo sapiens_hsa041102.66647444
14Basal transcription factors_Homo sapiens_hsa030222.59920757
15RNA degradation_Homo sapiens_hsa030182.24692888
16Fanconi anemia pathway_Homo sapiens_hsa034602.23399136
17Non-homologous end-joining_Homo sapiens_hsa034502.16505398
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84356071
19Vitamin B6 metabolism_Homo sapiens_hsa007501.63372481
20* Purine metabolism_Homo sapiens_hsa002301.63132464
21mRNA surveillance pathway_Homo sapiens_hsa030151.60885638
22One carbon pool by folate_Homo sapiens_hsa006701.58821208
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47997037
24Protein export_Homo sapiens_hsa030601.45603944
25Propanoate metabolism_Homo sapiens_hsa006401.41675407
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36289576
27p53 signaling pathway_Homo sapiens_hsa041151.34835594
28Parkinsons disease_Homo sapiens_hsa050121.31711416
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31697695
30Steroid biosynthesis_Homo sapiens_hsa001001.30708704
31Oxidative phosphorylation_Homo sapiens_hsa001901.30526045
32Butanoate metabolism_Homo sapiens_hsa006501.27870046
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25664105
34Pyruvate metabolism_Homo sapiens_hsa006201.19590094
35* Epstein-Barr virus infection_Homo sapiens_hsa051691.17523615
36Huntingtons disease_Homo sapiens_hsa050161.14908328
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00805435
38Oocyte meiosis_Homo sapiens_hsa041141.00128229
39Fatty acid elongation_Homo sapiens_hsa000620.98801186
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91321288
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87943518
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75342065
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74894236
44Pentose phosphate pathway_Homo sapiens_hsa000300.73517726
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73034882
46Herpes simplex infection_Homo sapiens_hsa051680.71934268
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70130185
48Lysine degradation_Homo sapiens_hsa003100.69850866
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.68786890
50Folate biosynthesis_Homo sapiens_hsa007900.65838785
51Glutathione metabolism_Homo sapiens_hsa004800.65542279
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65530378
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.61727759
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61657775
55Systemic lupus erythematosus_Homo sapiens_hsa053220.61147988
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57228910
57Antigen processing and presentation_Homo sapiens_hsa046120.56532975
58HTLV-I infection_Homo sapiens_hsa051660.55813013
59Viral carcinogenesis_Homo sapiens_hsa052030.54220219
60Alzheimers disease_Homo sapiens_hsa050100.53811592
61Fatty acid metabolism_Homo sapiens_hsa012120.51388524
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50930716
63Arachidonic acid metabolism_Homo sapiens_hsa005900.48860789
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48087167
65TGF-beta signaling pathway_Homo sapiens_hsa043500.46159419
66Phototransduction_Homo sapiens_hsa047440.45638169
67Biosynthesis of amino acids_Homo sapiens_hsa012300.45180855
68Hippo signaling pathway_Homo sapiens_hsa043900.44145507
69Arginine and proline metabolism_Homo sapiens_hsa003300.43205895
70Primary immunodeficiency_Homo sapiens_hsa053400.40929197
71Legionellosis_Homo sapiens_hsa051340.39522705
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39130067
73Regulation of autophagy_Homo sapiens_hsa041400.38536736
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.38066166
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37843842
76Thyroid cancer_Homo sapiens_hsa052160.36853852
77Peroxisome_Homo sapiens_hsa041460.36041856
78Fructose and mannose metabolism_Homo sapiens_hsa000510.34461310
79* Metabolic pathways_Homo sapiens_hsa011000.34120824
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33899947
81MicroRNAs in cancer_Homo sapiens_hsa052060.33637594
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33556703
83N-Glycan biosynthesis_Homo sapiens_hsa005100.32910138
84Shigellosis_Homo sapiens_hsa051310.32311432
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31160973
86Sulfur relay system_Homo sapiens_hsa041220.30777746
87beta-Alanine metabolism_Homo sapiens_hsa004100.30578184
88Nitrogen metabolism_Homo sapiens_hsa009100.29518500
89Collecting duct acid secretion_Homo sapiens_hsa049660.29334542
90Tryptophan metabolism_Homo sapiens_hsa003800.28121661
91Other glycan degradation_Homo sapiens_hsa005110.27920397
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.26699031
93Vibrio cholerae infection_Homo sapiens_hsa051100.24904205
94Sulfur metabolism_Homo sapiens_hsa009200.24899702
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24431666
96Colorectal cancer_Homo sapiens_hsa052100.24129559
97Fatty acid degradation_Homo sapiens_hsa000710.23688952
98Basal cell carcinoma_Homo sapiens_hsa052170.22570288
99Small cell lung cancer_Homo sapiens_hsa052220.22183499
100Sphingolipid metabolism_Homo sapiens_hsa006000.21955560
101Asthma_Homo sapiens_hsa053100.21554023
102Cardiac muscle contraction_Homo sapiens_hsa042600.21262474
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20658801
104Apoptosis_Homo sapiens_hsa042100.19484334
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19290602
106Carbon metabolism_Homo sapiens_hsa012000.19069864
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18789555
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18649819
109Measles_Homo sapiens_hsa051620.18444505
110Alcoholism_Homo sapiens_hsa050340.16607622
111Galactose metabolism_Homo sapiens_hsa000520.16304083
112Allograft rejection_Homo sapiens_hsa053300.16283358
113Tight junction_Homo sapiens_hsa045300.14740546
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14574130
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14439570
116Notch signaling pathway_Homo sapiens_hsa043300.13811816
117Hedgehog signaling pathway_Homo sapiens_hsa043400.13533092
118Rheumatoid arthritis_Homo sapiens_hsa053230.13274548
119Wnt signaling pathway_Homo sapiens_hsa043100.12933250
120Linoleic acid metabolism_Homo sapiens_hsa005910.12916972
121HIF-1 signaling pathway_Homo sapiens_hsa040660.12093461
122Pathways in cancer_Homo sapiens_hsa052000.11773696
123Hematopoietic cell lineage_Homo sapiens_hsa046400.11507354
124Melanoma_Homo sapiens_hsa052180.11079471
125Selenocompound metabolism_Homo sapiens_hsa004500.10150234
126Graft-versus-host disease_Homo sapiens_hsa053320.10086720
127Vitamin digestion and absorption_Homo sapiens_hsa049770.09913115
128Influenza A_Homo sapiens_hsa051640.09315749
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.08626807
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.08426473
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08413097

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