POLR2G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.69103195
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.40274735
3ATP synthesis coupled proton transport (GO:0015986)6.40274735
4protein neddylation (GO:0045116)5.54563187
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.49414193
6chaperone-mediated protein transport (GO:0072321)5.15121482
7respiratory electron transport chain (GO:0022904)4.81869248
8electron transport chain (GO:0022900)4.69717341
9proteasome assembly (GO:0043248)4.67137654
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.26922854
11translational elongation (GO:0006414)4.22711212
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.13312933
13protein complex biogenesis (GO:0070271)4.03587346
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.02475454
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.02475454
16NADH dehydrogenase complex assembly (GO:0010257)4.02475454
17sequestering of actin monomers (GO:0042989)3.99826510
18cullin deneddylation (GO:0010388)3.91456406
19termination of RNA polymerase III transcription (GO:0006386)3.89503561
20transcription elongation from RNA polymerase III promoter (GO:0006385)3.89503561
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.87660513
22regulation of cellular amino acid metabolic process (GO:0006521)3.83838732
23negative regulation of ligase activity (GO:0051352)3.83466060
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.83466060
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82072785
26protein deneddylation (GO:0000338)3.81919209
27viral life cycle (GO:0019058)3.80987456
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.77792988
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.75737186
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.75605285
31inner mitochondrial membrane organization (GO:0007007)3.75409754
32translational initiation (GO:0006413)3.72678910
33intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68564376
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68564376
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67648416
36cellular protein complex disassembly (GO:0043624)3.66645116
37DNA deamination (GO:0045006)3.66619431
38mitochondrial respiratory chain complex assembly (GO:0033108)3.66325353
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.65604136
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.64557699
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.64557699
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.64557699
43* 7-methylguanosine mRNA capping (GO:0006370)3.62028176
44* RNA capping (GO:0036260)3.58194696
45* 7-methylguanosine RNA capping (GO:0009452)3.58194696
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58045622
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.53299596
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.52416452
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.52416452
50establishment of integrated proviral latency (GO:0075713)3.50131365
51signal transduction involved in cell cycle checkpoint (GO:0072395)3.48238376
52chromatin remodeling at centromere (GO:0031055)3.44609025
53ribosomal small subunit biogenesis (GO:0042274)3.43086463
54CENP-A containing nucleosome assembly (GO:0034080)3.42238501
55GTP biosynthetic process (GO:0006183)3.40115778
56spliceosomal snRNP assembly (GO:0000387)3.35780125
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.34566162
58establishment of viral latency (GO:0019043)3.28032426
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27718993
60establishment of protein localization to mitochondrion (GO:0072655)3.27267580
61base-excision repair, AP site formation (GO:0006285)3.27090476
62hydrogen ion transmembrane transport (GO:1902600)3.26977295
63protein targeting to mitochondrion (GO:0006626)3.25074380
64positive regulation of ligase activity (GO:0051351)3.17689998
65platelet dense granule organization (GO:0060155)3.17582977
66telomere maintenance via semi-conservative replication (GO:0032201)3.16757391
67protein complex disassembly (GO:0043241)3.16620347
68regulation of mitochondrial translation (GO:0070129)3.16614580
69pseudouridine synthesis (GO:0001522)3.16548460
70long-chain fatty acid biosynthetic process (GO:0042759)3.16458969
71pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.15877078
72deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.11228745
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.11086127
74ribosomal small subunit assembly (GO:0000028)3.10782704
75intracellular protein transmembrane import (GO:0044743)3.07243872
76macromolecular complex disassembly (GO:0032984)3.05807377
77pyrimidine nucleotide catabolic process (GO:0006244)3.03424917
78substantia nigra development (GO:0021762)3.03238172
79ATP biosynthetic process (GO:0006754)3.02791941
80regulation of cellular amine metabolic process (GO:0033238)3.01884156
81purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01817908
82peptidyl-histidine modification (GO:0018202)3.01337918
83respiratory chain complex IV assembly (GO:0008535)3.00277297
84axon ensheathment in central nervous system (GO:0032291)2.99517998
85central nervous system myelination (GO:0022010)2.99517998
86cotranslational protein targeting to membrane (GO:0006613)2.99090365
87deoxyribonucleotide catabolic process (GO:0009264)2.99072447
88protein localization to mitochondrion (GO:0070585)2.96998817
89ATP hydrolysis coupled proton transport (GO:0015991)2.95546749
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.95546749
91guanosine-containing compound biosynthetic process (GO:1901070)2.94501568
92proton transport (GO:0015992)2.93966066
93deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.93014888
94antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.92553791
95UTP biosynthetic process (GO:0006228)2.90392326
96regulation of ubiquitin-protein transferase activity (GO:0051438)2.89130719
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88554491
98protein targeting to ER (GO:0045047)2.88390586
99DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.88379939
100translation (GO:0006412)2.87029799
101transcription elongation from RNA polymerase I promoter (GO:0006362)2.84651048
102hydrogen transport (GO:0006818)2.84600881
103cytochrome complex assembly (GO:0017004)2.83614746
104regulation of ligase activity (GO:0051340)2.82435736
105signal peptide processing (GO:0006465)2.81144798
106positive regulation of cell cycle arrest (GO:0071158)2.80689074
107protein localization to endoplasmic reticulum (GO:0070972)2.78759381
108ribonucleoside triphosphate biosynthetic process (GO:0009201)2.75448207
109establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73751266
110ribosomal large subunit biogenesis (GO:0042273)2.72846023
111maturation of SSU-rRNA (GO:0030490)2.71747027
112rRNA modification (GO:0000154)2.70142747
113viral transcription (GO:0019083)2.69317305
114oxidative phosphorylation (GO:0006119)2.69254772
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67599680
116translational termination (GO:0006415)2.66491850
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65294595
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65294595
119* transcription-coupled nucleotide-excision repair (GO:0006283)2.63349159
120positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.61757052
121cellular component biogenesis (GO:0044085)2.60633669
122* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60124120
123protein-cofactor linkage (GO:0018065)2.56151352
124* transcription elongation from RNA polymerase II promoter (GO:0006368)2.55299259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.13119548
2* GABP_17652178_ChIP-ChIP_JURKAT_Human4.69577088
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.48915215
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.93379462
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.82214507
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78310772
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.55210823
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.45536844
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.43145218
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42645582
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.32000662
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.15539623
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.83966741
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76736929
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.70169737
16VDR_23849224_ChIP-Seq_CD4+_Human2.53448815
17* SRF_21415370_ChIP-Seq_HL-1_Mouse2.36939442
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34719597
19* ELK1_19687146_ChIP-ChIP_HELA_Human2.34079784
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25930873
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24759680
22DCP1A_22483619_ChIP-Seq_HELA_Human2.19107692
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14893553
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07485951
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.03130999
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95819698
27FOXP3_21729870_ChIP-Seq_TREG_Human1.87634848
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85277308
29* XRN2_22483619_ChIP-Seq_HELA_Human1.81146119
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80971917
31* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79916410
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72921808
33* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71542671
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70299007
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65435269
36GABP_19822575_ChIP-Seq_HepG2_Human1.65070254
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64715194
38TTF2_22483619_ChIP-Seq_HELA_Human1.64254083
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.54151880
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51609158
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49045084
42VDR_22108803_ChIP-Seq_LS180_Human1.47872257
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45709558
44E2F7_22180533_ChIP-Seq_HELA_Human1.40739925
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39762911
46FUS_26573619_Chip-Seq_HEK293_Human1.39075525
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36810836
48* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35704911
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35649735
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33577632
51TAF15_26573619_Chip-Seq_HEK293_Human1.32851442
52ZNF274_21170338_ChIP-Seq_K562_Hela1.28970930
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26343630
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24313983
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21454710
56MYC_18940864_ChIP-ChIP_HL60_Human1.20452245
57KDM5A_27292631_Chip-Seq_BREAST_Human1.20400270
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20163957
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14928751
60IRF1_19129219_ChIP-ChIP_H3396_Human1.14218811
61EWS_26573619_Chip-Seq_HEK293_Human1.12775968
62CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12628989
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11924357
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11683851
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11038317
66* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10549121
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09862581
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08646289
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07206078
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07115465
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06164960
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05695699
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.04791460
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04486372
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.03129723
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03110424
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02288582
78* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02102575
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.01479000
80CIITA_25753668_ChIP-Seq_RAJI_Human1.01339264
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00648415
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.00517242
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99708278
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99418576
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99408270
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.98948480
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96775093
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.95846233
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95210717
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91693270
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90615793
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88843325
93ER_23166858_ChIP-Seq_MCF-7_Human0.87729534
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86733465
95IGF1R_20145208_ChIP-Seq_DFB_Human0.86120813
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85241363
97TP53_22573176_ChIP-Seq_HFKS_Human0.84471779
98GBX2_23144817_ChIP-Seq_PC3_Human0.83583298
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83100098
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82367979
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82196723
102FOXM1_23109430_ChIP-Seq_U2OS_Human0.81572539
103ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80697364
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79550998
105* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.78465528
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.78282792
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77902182
108FOXP1_21924763_ChIP-Seq_HESCs_Human0.76507218
109* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75439904
110P300_19829295_ChIP-Seq_ESCs_Human0.74915135
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74773275
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74634800
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73457390
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73131963
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72557141
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72462933
117JUN_21703547_ChIP-Seq_K562_Human0.71405906
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71125208
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.70667268
120ERG_20517297_ChIP-Seq_VCAP_Human0.69788218
121HTT_18923047_ChIP-ChIP_STHdh_Human0.69568918
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.69100804
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68521849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization4.24586672
2MP0003880_abnormal_central_pattern3.70811187
3MP0001905_abnormal_dopamine_level3.04969028
4MP0003806_abnormal_nucleotide_metabolis3.03940806
5MP0008057_abnormal_DNA_replication2.37365838
6MP0003136_yellow_coat_color2.35470320
7MP0002102_abnormal_ear_morphology2.29980748
8MP0002163_abnormal_gland_morphology2.29544707
9MP0003011_delayed_dark_adaptation2.24744189
10MP0002653_abnormal_ependyma_morphology2.17911812
11MP0001188_hyperpigmentation2.05234700
12MP0005084_abnormal_gallbladder_morpholo2.01118330
13MP0010030_abnormal_orbit_morphology2.00991244
14MP0001293_anophthalmia1.97142411
15MP0008877_abnormal_DNA_methylation1.95418150
16MP0004142_abnormal_muscle_tone1.89070212
17MP0003111_abnormal_nucleus_morphology1.88954822
18MP0009379_abnormal_foot_pigmentation1.87251418
19MP0006276_abnormal_autonomic_nervous1.86769493
20MP0005409_darkened_coat_color1.86227093
21MP0008932_abnormal_embryonic_tissue1.86203356
22MP0006292_abnormal_olfactory_placode1.82765961
23MP0003718_maternal_effect1.81343949
24MP0004957_abnormal_blastocyst_morpholog1.80274665
25MP0000920_abnormal_myelination1.79627919
26MP0005171_absent_coat_pigmentation1.79080846
27MP0002272_abnormal_nervous_system1.77235992
28MP0005394_taste/olfaction_phenotype1.73725156
29MP0005499_abnormal_olfactory_system1.73725156
30MP0002736_abnormal_nociception_after1.72841326
31MP0003693_abnormal_embryo_hatching1.67183307
32MP0005379_endocrine/exocrine_gland_phen1.66925199
33MP0002064_seizures1.62880883
34MP0001984_abnormal_olfaction1.62467986
35MP0002148_abnormal_hypersensitivity_rea1.60696834
36MP0008995_early_reproductive_senescence1.58339470
37MP0002638_abnormal_pupillary_reflex1.57508509
38MP0004270_analgesia1.54795747
39MP0009046_muscle_twitch1.54266159
40MP0000372_irregular_coat_pigmentation1.52565117
41MP0002734_abnormal_mechanical_nocicepti1.49508491
42MP0008058_abnormal_DNA_repair1.47811960
43MP0005075_abnormal_melanosome_morpholog1.44542352
44MP0001485_abnormal_pinna_reflex1.44448502
45MP0009745_abnormal_behavioral_response1.44011590
46MP0010386_abnormal_urinary_bladder1.41951859
47MP0001968_abnormal_touch/_nociception1.40219343
48MP0001986_abnormal_taste_sensitivity1.37585872
49MP0009697_abnormal_copulation1.37093120
50MP0002095_abnormal_skin_pigmentation1.32930000
51MP0010094_abnormal_chromosome_stability1.30513979
52MP0006072_abnormal_retinal_apoptosis1.29321096
53MP0003077_abnormal_cell_cycle1.28681579
54MP0005408_hypopigmentation1.26228632
55MP0005671_abnormal_response_to1.24514969
56MP0004742_abnormal_vestibular_system1.23379179
57MP0002572_abnormal_emotion/affect_behav1.22044678
58MP0006036_abnormal_mitochondrial_physio1.21670855
59MP0003635_abnormal_synaptic_transmissio1.20250653
60MP0002876_abnormal_thyroid_physiology1.19798163
61MP0002735_abnormal_chemical_nociception1.19486387
62MP0001440_abnormal_grooming_behavior1.18395704
63MP0008260_abnormal_autophagy1.18056131
64MP0001970_abnormal_pain_threshold1.17947776
65MP0003186_abnormal_redox_activity1.17935175
66MP0002282_abnormal_trachea_morphology1.15708202
67MP0003786_premature_aging1.14191568
68MP0002234_abnormal_pharynx_morphology1.12998200
69MP0003122_maternal_imprinting1.11472909
70MP0001764_abnormal_homeostasis1.10529434
71MP0005386_behavior/neurological_phenoty1.08641378
72MP0004924_abnormal_behavior1.08641378
73MP0001835_abnormal_antigen_presentation1.07831696
74MP0002210_abnormal_sex_determination1.06879049
75MP0006035_abnormal_mitochondrial_morpho1.06428571
76MP0000778_abnormal_nervous_system1.04866578
77MP0002733_abnormal_thermal_nociception1.03258961
78MP0002063_abnormal_learning/memory/cond1.03241509
79MP0008872_abnormal_physiological_respon1.03029637
80MP0002277_abnormal_respiratory_mucosa1.02939916
81MP0000015_abnormal_ear_pigmentation1.01817779
82MP0003123_paternal_imprinting1.01669645
83MP0000358_abnormal_cell_content/1.00816956
84MP0001486_abnormal_startle_reflex1.00494578
85MP0000049_abnormal_middle_ear1.00311915
86MP0002837_dystrophic_cardiac_calcinosis0.99683069
87MP0001727_abnormal_embryo_implantation0.97591974
88MP0003121_genomic_imprinting0.97216280
89MP0009785_altered_susceptibility_to0.96588204
90MP0004859_abnormal_synaptic_plasticity0.96417180
91MP0005646_abnormal_pituitary_gland0.94561753
92MP0002067_abnormal_sensory_capabilities0.94325120
93MP0001919_abnormal_reproductive_system0.93853128
94MP0005391_vision/eye_phenotype0.93304107
95MP0009333_abnormal_splenocyte_physiolog0.93192347
96MP0002160_abnormal_reproductive_system0.92963170
97MP0004147_increased_porphyrin_level0.92530753
98MP0003315_abnormal_perineum_morphology0.92453277
99MP0001963_abnormal_hearing_physiology0.92437138
100MP0002938_white_spotting0.91599156
101MP0002751_abnormal_autonomic_nervous0.91478666
102MP0001348_abnormal_lacrimal_gland0.91176243
103MP0001324_abnormal_eye_pigmentation0.91005854
104MP0001929_abnormal_gametogenesis0.90232900
105MP0002184_abnormal_innervation0.88267259
106MP0001346_abnormal_lacrimal_gland0.87835151
107MP0005310_abnormal_salivary_gland0.87766952
108MP0005000_abnormal_immune_tolerance0.87753900
109MP0003634_abnormal_glial_cell0.87276988
110MP0002090_abnormal_vision0.87194663
111MP0003950_abnormal_plasma_membrane0.85993568
112MP0001145_abnormal_male_reproductive0.85820159
113MP0002229_neurodegeneration0.85546742
114MP0005253_abnormal_eye_physiology0.85483307
115MP0000653_abnormal_sex_gland0.85281380
116MP0001286_abnormal_eye_development0.85160534
117MP0008789_abnormal_olfactory_epithelium0.84690381
118MP0005551_abnormal_eye_electrophysiolog0.83823681
119MP0005645_abnormal_hypothalamus_physiol0.82299332
120MP0000631_abnormal_neuroendocrine_gland0.81913109
121MP0005410_abnormal_fertilization0.81365087
122MP0002752_abnormal_somatic_nervous0.80320581
123MP0000026_abnormal_inner_ear0.80129102
124MP0002233_abnormal_nose_morphology0.79766776
125MP0005195_abnormal_posterior_eye0.78981123
126MP0002882_abnormal_neuron_morphology0.78450325
127MP0003632_abnormal_nervous_system0.77982010
128MP0001119_abnormal_female_reproductive0.77207266
129MP0002132_abnormal_respiratory_system0.75953700
130MP0008007_abnormal_cellular_replicative0.74469429
131MP0002066_abnormal_motor_capabilities/c0.73356461
132MP0000647_abnormal_sebaceous_gland0.73243134
133MP0003787_abnormal_imprinting0.72992152
134MP0003938_abnormal_ear_development0.72430475
135MP0000516_abnormal_urinary_system0.72221196
136MP0005367_renal/urinary_system_phenotyp0.72221196
137MP0004133_heterotaxia0.71378602
138MP0003567_abnormal_fetal_cardiomyocyte0.71226178
139MP0001501_abnormal_sleep_pattern0.70647752
140MP0008875_abnormal_xenobiotic_pharmacok0.70640556
141MP0005174_abnormal_tail_pigmentation0.70013590
142MP0005389_reproductive_system_phenotype0.69120411
143MP0000313_abnormal_cell_death0.67781843
144MP0003698_abnormal_male_reproductive0.67013744
145MP0003937_abnormal_limbs/digits/tail_de0.64532007
146MP0001853_heart_inflammation0.63313728
147MP0003119_abnormal_digestive_system0.61129884

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.38675498
2Abnormal mitochondria in muscle tissue (HP:0008316)5.59080014
3Mitochondrial inheritance (HP:0001427)5.42729873
4Progressive macrocephaly (HP:0004481)5.35050470
5Acute encephalopathy (HP:0006846)4.87342049
6Increased CSF lactate (HP:0002490)4.63486062
7Increased hepatocellular lipid droplets (HP:0006565)4.59927700
8Hepatocellular necrosis (HP:0001404)4.29859755
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.09855774
10Abnormality of glycolysis (HP:0004366)3.99012864
11Increased serum pyruvate (HP:0003542)3.99012864
12Renal Fanconi syndrome (HP:0001994)3.92320317
13Lipid accumulation in hepatocytes (HP:0006561)3.81249997
14Leukodystrophy (HP:0002415)3.65773759
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.61510757
16Parakeratosis (HP:0001036)3.55444684
17Hepatic necrosis (HP:0002605)3.46715736
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.43999521
193-Methylglutaconic aciduria (HP:0003535)3.43033003
20Cerebral hypomyelination (HP:0006808)3.36506784
21Exertional dyspnea (HP:0002875)3.28921613
22Exercise intolerance (HP:0003546)3.17285071
23Respiratory failure (HP:0002878)3.15841004
24Optic disc pallor (HP:0000543)3.09572680
25Increased serum lactate (HP:0002151)2.89053210
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73709737
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73709737
28Cerebral edema (HP:0002181)2.73341431
29Increased intramyocellular lipid droplets (HP:0012240)2.71634447
30Congenital ichthyosiform erythroderma (HP:0007431)2.70783197
31Aplastic anemia (HP:0001915)2.70644362
32Colon cancer (HP:0003003)2.65903279
33Birth length less than 3rd percentile (HP:0003561)2.63826125
34Respiratory difficulties (HP:0002880)2.61921730
35Lactic acidosis (HP:0003128)2.60451403
36Sensory axonal neuropathy (HP:0003390)2.59553372
37Abnormality of cells of the erythroid lineage (HP:0012130)2.59069517
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.56664605
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.56664605
40Medial flaring of the eyebrow (HP:0010747)2.51258737
41Abnormality of renal resorption (HP:0011038)2.48745540
42Neuroendocrine neoplasm (HP:0100634)2.47920261
43Hyperglycinemia (HP:0002154)2.44064522
44Lethargy (HP:0001254)2.42827450
45Molar tooth sign on MRI (HP:0002419)2.41452114
46Abnormality of midbrain morphology (HP:0002418)2.41452114
47Abnormal hair whorl (HP:0010721)2.40705024
48Abnormal number of erythroid precursors (HP:0012131)2.37715263
49Type I transferrin isoform profile (HP:0003642)2.35684094
50Congenital primary aphakia (HP:0007707)2.32429137
51Gait imbalance (HP:0002141)2.31056842
52Increased IgM level (HP:0003496)2.28872942
53Pancytopenia (HP:0001876)2.26406631
54Abnormality of the anterior horn cell (HP:0006802)2.20019112
55Degeneration of anterior horn cells (HP:0002398)2.20019112
56Congenital, generalized hypertrichosis (HP:0004540)2.20001506
57Nephrogenic diabetes insipidus (HP:0009806)2.19054329
58Pheochromocytoma (HP:0002666)2.18333872
59CNS hypomyelination (HP:0003429)2.17482343
60Irregular epiphyses (HP:0010582)2.16192867
61Breast hypoplasia (HP:0003187)2.16115543
62Meckel diverticulum (HP:0002245)2.13624064
63Vaginal atresia (HP:0000148)2.13477969
64Sclerocornea (HP:0000647)2.12475126
65X-linked dominant inheritance (HP:0001423)2.10539941
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08895913
67Emotional lability (HP:0000712)2.06762986
68Pallor (HP:0000980)2.05827779
69Methylmalonic aciduria (HP:0012120)2.05331653
70Genital tract atresia (HP:0001827)2.04628349
71Abnormality of the ileum (HP:0001549)2.03845596
72Methylmalonic acidemia (HP:0002912)2.00297929
73Generalized aminoaciduria (HP:0002909)1.99173250
74Oral leukoplakia (HP:0002745)1.96632336
75Increased muscle lipid content (HP:0009058)1.95219686
76Hypothermia (HP:0002045)1.94209062
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.93517342
78Absent thumb (HP:0009777)1.92887370
79Macrocytic anemia (HP:0001972)1.90938136
80Carpal bone hypoplasia (HP:0001498)1.90042361
81Glycosuria (HP:0003076)1.88629089
82Abnormality of urine glucose concentration (HP:0011016)1.88629089
83Abnormality of the labia minora (HP:0012880)1.87311093
84Atonic seizures (HP:0010819)1.85191512
85Progressive microcephaly (HP:0000253)1.84804612
86Aplasia/hypoplasia of the uterus (HP:0008684)1.84709303
87True hermaphroditism (HP:0010459)1.84071527
88Pancreatic cysts (HP:0001737)1.84058645
89Stenosis of the external auditory canal (HP:0000402)1.83861561
90CNS demyelination (HP:0007305)1.83337894
91Delusions (HP:0000746)1.82821758
92Reduced antithrombin III activity (HP:0001976)1.82521772
93Postnatal microcephaly (HP:0005484)1.81393702
94Reticulocytopenia (HP:0001896)1.80915134
95Triphalangeal thumb (HP:0001199)1.79592644
96Adrenal hypoplasia (HP:0000835)1.79010295
97Septo-optic dysplasia (HP:0100842)1.78247062
98Hypoplastic pelvis (HP:0008839)1.76558343
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73714045
100Abnormality of alanine metabolism (HP:0010916)1.73714045
101Hyperalaninemia (HP:0003348)1.73714045
102Abnormality of serum amino acid levels (HP:0003112)1.73018789
103Type 2 muscle fiber atrophy (HP:0003554)1.72697180
104Pancreatic fibrosis (HP:0100732)1.71493185
105Abnormality of the preputium (HP:0100587)1.69925837
106Abnormal protein glycosylation (HP:0012346)1.68432668
107Abnormal glycosylation (HP:0012345)1.68432668
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68432668
109Abnormal protein N-linked glycosylation (HP:0012347)1.68432668
110Microvesicular hepatic steatosis (HP:0001414)1.67909468
111Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67721952
112Dicarboxylic aciduria (HP:0003215)1.67721952
113Nephronophthisis (HP:0000090)1.66770146
114Myokymia (HP:0002411)1.66724025
115Abnormal autonomic nervous system physiology (HP:0012332)1.65492188
116Retinal dysplasia (HP:0007973)1.64689293
117Autoamputation (HP:0001218)1.64021726
118Anencephaly (HP:0002323)1.63557329
119Abnormal pupillary function (HP:0007686)1.62663929
120Muscle fiber atrophy (HP:0100295)1.61927135
121Hyperglycinuria (HP:0003108)1.61904383
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61103309
123Amniotic constriction ring (HP:0009775)1.60994682
124Abnormality of placental membranes (HP:0011409)1.60994682
125Poor coordination (HP:0002370)1.60438877
126Aplasia/Hypoplasia of the tongue (HP:0010295)1.59005901
127Poor head control (HP:0002421)1.58521007
128Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.58405658
129Hyperphosphaturia (HP:0003109)1.57327397
130Short tibia (HP:0005736)1.56632702
131IgG deficiency (HP:0004315)1.54829071
132Aplasia/Hypoplasia involving the musculature (HP:0001460)1.54800641
133Cleft eyelid (HP:0000625)1.54195773
134Blindness (HP:0000618)1.53966532
135Abnormality of the septum pellucidum (HP:0007375)1.53621477
136Small epiphyses (HP:0010585)1.51017741
137Rectovaginal fistula (HP:0000143)1.49352050
138Rectal fistula (HP:0100590)1.49352050
139Absent epiphyses (HP:0010577)1.49135664
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.49135664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.17333912
2PBK3.36608871
3BUB13.16117631
4BCKDK3.14471945
5ARAF2.94419763
6NME12.77537787
7STK392.76917694
8STK162.68549196
9BCR2.63592365
10MAP3K122.43183251
11MST42.40250426
12NUAK12.15416135
13LIMK12.13971602
14MAP4K22.13861560
15EIF2AK12.01622457
16EIF2AK31.97376511
17VRK11.96765781
18OXSR11.96424327
19BRAF1.79688872
20NEK11.79251202
21NME21.78746697
22SRPK11.78177412
23TESK21.72099706
24CASK1.69045195
25BMPR21.66828243
26KDR1.66021759
27TRIM281.63430239
28PNCK1.55312635
29CDK191.55287441
30WNK31.54200603
31PLK21.51104881
32WNK41.47622032
33PLK41.44465220
34TNIK1.42236968
35PIM21.41047798
36TSSK61.40416021
37IRAK41.35982074
38WEE11.35208983
39TAF11.27876457
40BMPR1B1.22772113
41TESK11.14049357
42PLK31.13699637
43IRAK21.07962518
44CSNK1G31.07535191
45TTK1.03324359
46MAP2K71.01407637
47GRK70.98751855
48NEK60.97244205
49GRK50.96749340
50TLK10.95131552
51MKNK10.93114625
52UHMK10.91517013
53PDK20.90460097
54AURKB0.89487317
55CAMK2B0.88568561
56MAPKAPK50.88098412
57IRAK30.87980961
58ADRBK20.87084346
59AKT30.87076174
60ATR0.85638317
61DYRK20.84510111
62DYRK30.82840606
63AURKA0.82033061
64RPS6KA40.81248516
65BRSK20.81227276
66DAPK10.80058911
67ABL20.79705372
68RIPK40.79452300
69CCNB10.78365284
70EPHB20.76423990
71MYLK0.75038723
72IRAK10.74171160
73CHEK20.72617653
74CDK140.71652178
75CDC70.71081222
76MAP3K130.71009559
77FGR0.69092280
78GRK10.68820130
79MAP3K40.68512894
80CAMK2D0.64968053
81MAPK130.63976453
82PLK10.63525251
83LRRK20.63139856
84CSNK1A1L0.61939222
85PKN10.61182223
86CDK180.59240034
87MAP3K140.58821820
88BRSK10.58504385
89ROCK20.58188728
90MUSK0.56920655
91ACVR1B0.56273194
92YES10.55506917
93MOS0.54557206
94CLK10.54540740
95CAMKK20.54466798
96CAMK2A0.53512861
97CDK150.53301955
98ZAK0.52973674
99DAPK30.52862257
100INSRR0.52747678
101CDK80.52331505
102ERBB30.52286388
103PASK0.51102634
104EIF2AK20.50674408
105CSNK2A10.49803695
106CSNK1G20.49738971
107TXK0.49186864
108ILK0.48790442
109CDK11A0.48275646
110CAMK2G0.47720487
111RPS6KA50.47555471
112PAK10.47378472
113PRKCG0.47269070
114CSNK1G10.46165814
115PRKCQ0.45559802
116SIK30.45339621
117PRKCE0.45131578
118RAF10.43103442
119CSNK2A20.42677434
120ADRBK10.42590827
121MAP3K110.40726121
122MKNK20.38916697
123MINK10.38499694
124CDK70.38267639
125PRKCI0.38092597
126MAPKAPK30.37647959
127SYK0.36175355
128IKBKB0.34778021
129LYN0.34612996
130TAOK30.34237208
131ATM0.31237932
132NEK20.31073463
133CSNK1A10.30715567
134STK40.30032433
135TGFBR10.24997635
136PINK10.24913667
137CHEK10.23680967

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.81855549
2Proteasome_Homo sapiens_hsa030504.67507212
3Parkinsons disease_Homo sapiens_hsa050124.01878611
4Ribosome_Homo sapiens_hsa030103.32140000
5Protein export_Homo sapiens_hsa030603.32036503
6* RNA polymerase_Homo sapiens_hsa030203.07955893
7Alzheimers disease_Homo sapiens_hsa050102.99008116
8Huntingtons disease_Homo sapiens_hsa050162.94378848
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28529332
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.25540690
11Collecting duct acid secretion_Homo sapiens_hsa049662.09316448
12DNA replication_Homo sapiens_hsa030301.82526650
13Mismatch repair_Homo sapiens_hsa034301.78987311
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78456046
15Homologous recombination_Homo sapiens_hsa034401.69851944
16Vibrio cholerae infection_Homo sapiens_hsa051101.65572206
17Basal transcription factors_Homo sapiens_hsa030221.65305270
18Spliceosome_Homo sapiens_hsa030401.65269922
19Nucleotide excision repair_Homo sapiens_hsa034201.63979478
20* Pyrimidine metabolism_Homo sapiens_hsa002401.53017708
21Cardiac muscle contraction_Homo sapiens_hsa042601.50200365
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47409608
23Rheumatoid arthritis_Homo sapiens_hsa053231.38582698
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36932373
25Allograft rejection_Homo sapiens_hsa053301.34570880
26Propanoate metabolism_Homo sapiens_hsa006401.27945343
27One carbon pool by folate_Homo sapiens_hsa006701.26128714
28Graft-versus-host disease_Homo sapiens_hsa053321.25263452
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22718425
30Type I diabetes mellitus_Homo sapiens_hsa049401.22114576
31RNA transport_Homo sapiens_hsa030131.20877585
32Sulfur relay system_Homo sapiens_hsa041221.20634933
33Steroid biosynthesis_Homo sapiens_hsa001001.18598815
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18559185
35RNA degradation_Homo sapiens_hsa030181.17339279
36Non-homologous end-joining_Homo sapiens_hsa034501.16843328
37Pyruvate metabolism_Homo sapiens_hsa006201.14287216
38Autoimmune thyroid disease_Homo sapiens_hsa053201.14029203
39Base excision repair_Homo sapiens_hsa034101.11720384
40Fatty acid elongation_Homo sapiens_hsa000621.08280293
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06764865
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06487355
43Synaptic vesicle cycle_Homo sapiens_hsa047211.01044932
44* Purine metabolism_Homo sapiens_hsa002300.99909053
45Ether lipid metabolism_Homo sapiens_hsa005650.99434029
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.99203284
47Peroxisome_Homo sapiens_hsa041460.93445325
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90729662
49Serotonergic synapse_Homo sapiens_hsa047260.90472735
50Asthma_Homo sapiens_hsa053100.87885684
51Fanconi anemia pathway_Homo sapiens_hsa034600.86916485
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84470264
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84257215
54Butanoate metabolism_Homo sapiens_hsa006500.83000226
55Cell cycle_Homo sapiens_hsa041100.80217763
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79988560
57Nicotine addiction_Homo sapiens_hsa050330.78552770
58Carbon metabolism_Homo sapiens_hsa012000.78011166
59Phagosome_Homo sapiens_hsa041450.77122071
60* Epstein-Barr virus infection_Homo sapiens_hsa051690.75791559
61Biosynthesis of amino acids_Homo sapiens_hsa012300.71235907
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70906594
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68931216
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68878495
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65576467
66Arachidonic acid metabolism_Homo sapiens_hsa005900.65418416
67Sphingolipid metabolism_Homo sapiens_hsa006000.65250965
68Phototransduction_Homo sapiens_hsa047440.62681544
69Selenocompound metabolism_Homo sapiens_hsa004500.62359940
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62160584
71Regulation of autophagy_Homo sapiens_hsa041400.60267550
72Caffeine metabolism_Homo sapiens_hsa002320.57467198
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.57194334
74Oocyte meiosis_Homo sapiens_hsa041140.56993027
75Sulfur metabolism_Homo sapiens_hsa009200.54369001
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50782043
77Primary immunodeficiency_Homo sapiens_hsa053400.50259140
78* Metabolic pathways_Homo sapiens_hsa011000.48856695
79GABAergic synapse_Homo sapiens_hsa047270.47664696
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.47597048
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47583024
82Glutathione metabolism_Homo sapiens_hsa004800.45603802
83Nitrogen metabolism_Homo sapiens_hsa009100.44824424
84Linoleic acid metabolism_Homo sapiens_hsa005910.43718076
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42099159
86Shigellosis_Homo sapiens_hsa051310.41537251
87Morphine addiction_Homo sapiens_hsa050320.41255122
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38189975
89Dopaminergic synapse_Homo sapiens_hsa047280.38026469
90Tryptophan metabolism_Homo sapiens_hsa003800.37795805
91Chemical carcinogenesis_Homo sapiens_hsa052040.37754209
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37577196
93beta-Alanine metabolism_Homo sapiens_hsa004100.36875933
94Fatty acid metabolism_Homo sapiens_hsa012120.36719366
95Alcoholism_Homo sapiens_hsa050340.36535633
96Long-term depression_Homo sapiens_hsa047300.36305790
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36074778
98mRNA surveillance pathway_Homo sapiens_hsa030150.34947189
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.30810353
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30593786
101Antigen processing and presentation_Homo sapiens_hsa046120.29505576
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28280062
103Taste transduction_Homo sapiens_hsa047420.27710756
104Glutamatergic synapse_Homo sapiens_hsa047240.27130502
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27047109
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26883182
107Circadian entrainment_Homo sapiens_hsa047130.24478182
108Pentose phosphate pathway_Homo sapiens_hsa000300.23990990
109Tyrosine metabolism_Homo sapiens_hsa003500.23874913
110Basal cell carcinoma_Homo sapiens_hsa052170.23820439
111Long-term potentiation_Homo sapiens_hsa047200.22077472
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21973510
113Arginine and proline metabolism_Homo sapiens_hsa003300.21881094
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21127473
115Amphetamine addiction_Homo sapiens_hsa050310.20984639
116p53 signaling pathway_Homo sapiens_hsa041150.20694764
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20573479
118Cholinergic synapse_Homo sapiens_hsa047250.20176366
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19722407
120Fatty acid degradation_Homo sapiens_hsa000710.19537384
121Axon guidance_Homo sapiens_hsa043600.18355271
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18154660
123N-Glycan biosynthesis_Homo sapiens_hsa005100.18076882
124Pertussis_Homo sapiens_hsa051330.17265505
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17051456
126Legionellosis_Homo sapiens_hsa051340.16886736
127Systemic lupus erythematosus_Homo sapiens_hsa053220.16476395
128Malaria_Homo sapiens_hsa051440.16088193
129African trypanosomiasis_Homo sapiens_hsa051430.15676103
130Salmonella infection_Homo sapiens_hsa051320.15300720
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.14753963
132Lysosome_Homo sapiens_hsa041420.12830552
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.12792767
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11019614
135Olfactory transduction_Homo sapiens_hsa047400.10460484
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.09103436
137Folate biosynthesis_Homo sapiens_hsa007900.09082803

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