POLR2J4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.95222271
2protein complex biogenesis (GO:0070271)4.17170660
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.15133300
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.08519422
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.06111281
6ATP synthesis coupled proton transport (GO:0015986)4.06111281
7mitochondrial respiratory chain complex assembly (GO:0033108)3.87981086
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.81555614
9NADH dehydrogenase complex assembly (GO:0010257)3.81555614
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81555614
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.69619605
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40339595
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.39793652
14platelet dense granule organization (GO:0060155)3.37447001
15immunoglobulin mediated immune response (GO:0016064)3.30093875
16base-excision repair, AP site formation (GO:0006285)3.29849659
17electron transport chain (GO:0022900)3.26637445
18preassembly of GPI anchor in ER membrane (GO:0016254)3.25415242
19regulation of mitochondrial translation (GO:0070129)3.24842330
20respiratory electron transport chain (GO:0022904)3.23414927
21negative regulation of B cell apoptotic process (GO:0002903)3.15420040
22proteasome assembly (GO:0043248)3.13639745
23cytochrome complex assembly (GO:0017004)3.13133022
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12807062
25pyrimidine nucleotide catabolic process (GO:0006244)3.12662350
26response to interferon-beta (GO:0035456)3.11728569
27inner mitochondrial membrane organization (GO:0007007)3.10134252
28chaperone-mediated protein transport (GO:0072321)3.08957966
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07251045
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07251045
31deoxyribonucleotide catabolic process (GO:0009264)3.07146865
32cellular response to interferon-beta (GO:0035458)2.98914579
33indolalkylamine catabolic process (GO:0046218)2.98899512
34tryptophan catabolic process (GO:0006569)2.98899512
35indole-containing compound catabolic process (GO:0042436)2.98899512
36transcription elongation from RNA polymerase III promoter (GO:0006385)2.94817026
37termination of RNA polymerase III transcription (GO:0006386)2.94817026
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94253369
39respiratory chain complex IV assembly (GO:0008535)2.87875983
40deoxyribose phosphate catabolic process (GO:0046386)2.86364625
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86343339
42sequestering of actin monomers (GO:0042989)2.83855737
43regulation of cellular amino acid metabolic process (GO:0006521)2.83643873
44B cell mediated immunity (GO:0019724)2.80662416
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80501074
46ubiquinone biosynthetic process (GO:0006744)2.79490335
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78022271
48positive regulation of granulocyte differentiation (GO:0030854)2.75479382
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75112754
50viral transcription (GO:0019083)2.72162689
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71819629
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71819629
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71819629
54positive regulation of T cell mediated cytotoxicity (GO:0001916)2.71179723
55positive regulation of defense response to virus by host (GO:0002230)2.70299133
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70261058
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70261058
58GPI anchor biosynthetic process (GO:0006506)2.67139030
59tryptophan metabolic process (GO:0006568)2.65625505
60kynurenine metabolic process (GO:0070189)2.63477097
61regulation of T cell mediated cytotoxicity (GO:0001914)2.61749575
62translational termination (GO:0006415)2.61731602
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60896465
64ubiquinone metabolic process (GO:0006743)2.60840320
65deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60778839
66purine deoxyribonucleotide catabolic process (GO:0009155)2.60751606
67peptidyl-histidine modification (GO:0018202)2.59911854
68cotranslational protein targeting to membrane (GO:0006613)2.59579083
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59520156
70negative regulation of ligase activity (GO:0051352)2.59520156
71negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.59187320
72positive regulation of prostaglandin secretion (GO:0032308)2.59131619
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.58727536
74cytidine metabolic process (GO:0046087)2.58134575
75cytidine catabolic process (GO:0006216)2.58134575
76cytidine deamination (GO:0009972)2.58134575
77iron-sulfur cluster assembly (GO:0016226)2.56966169
78metallo-sulfur cluster assembly (GO:0031163)2.56966169
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.56839513
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56839513
81positive regulation of gamma-delta T cell activation (GO:0046645)2.56309679
82signal transduction involved in cell cycle checkpoint (GO:0072395)2.56210380
83establishment of viral latency (GO:0019043)2.55797300
84regulation of B cell apoptotic process (GO:0002902)2.54667346
85protein targeting to ER (GO:0045047)2.53685671
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.53068575
87protein targeting to mitochondrion (GO:0006626)2.51596693
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.49062499
89defense response to protozoan (GO:0042832)2.47550586
90maturation of 5.8S rRNA (GO:0000460)2.46972483
91spliceosomal snRNP assembly (GO:0000387)2.46581063
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45314024
93GPI anchor metabolic process (GO:0006505)2.44627143
94establishment of protein localization to mitochondrion (GO:0072655)2.43291586
95ribosomal large subunit biogenesis (GO:0042273)2.42799144
96protein localization to endoplasmic reticulum (GO:0070972)2.41699829
97regulation of B cell receptor signaling pathway (GO:0050855)2.39208612
98C-terminal protein lipidation (GO:0006501)2.39040843
99mitochondrial calcium ion transport (GO:0006851)2.38361754
100water-soluble vitamin biosynthetic process (GO:0042364)2.37713594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.04452509
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.89463336
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.73279555
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.46871622
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33747753
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27171542
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.23151621
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.95146293
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86293701
10VDR_23849224_ChIP-Seq_CD4+_Human2.79548270
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71919383
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60075754
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56384543
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.48550489
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48517275
16FOXP3_21729870_ChIP-Seq_TREG_Human2.44971573
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39398202
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35144284
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.22180689
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18657502
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.18484662
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.15055236
23ELK1_19687146_ChIP-ChIP_HELA_Human2.12642877
24CIITA_25753668_ChIP-Seq_RAJI_Human2.08761849
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.02847567
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00869732
27SPI1_23547873_ChIP-Seq_NB4_Human1.90586177
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90194821
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.87647410
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86821950
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86023337
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83873627
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82209913
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80153371
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.75701943
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74758998
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.74463387
38ZNF274_21170338_ChIP-Seq_K562_Hela1.71938136
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69063483
40GABP_19822575_ChIP-Seq_HepG2_Human1.65054024
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60445087
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58984532
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58034379
44MYB_26560356_Chip-Seq_TH2_Human1.54454913
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53861101
46* DCP1A_22483619_ChIP-Seq_HELA_Human1.51993513
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49391251
48FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49172931
49XRN2_22483619_ChIP-Seq_HELA_Human1.48599002
50TTF2_22483619_ChIP-Seq_HELA_Human1.44439316
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43435239
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42902214
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40960471
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40444600
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.40369621
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37470630
57SCL_19346495_ChIP-Seq_HPC-7_Human1.35218845
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34858846
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34278054
60RUNX_20019798_ChIP-Seq_JUKART_Human1.33204338
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32054593
62GATA3_26560356_Chip-Seq_TH2_Human1.31622333
63VDR_21846776_ChIP-Seq_THP-1_Human1.30257187
64MYC_18940864_ChIP-ChIP_HL60_Human1.27452803
65BCL6_27268052_Chip-Seq_Bcells_Human1.26966905
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25607243
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23164315
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23106524
69UTX_26944678_Chip-Seq_JUKART_Human1.20905953
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20076815
71IRF1_19129219_ChIP-ChIP_H3396_Human1.19600260
72* P300_27268052_Chip-Seq_Bcells_Human1.19425439
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18290013
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18026122
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.16738259
76KDM5A_27292631_Chip-Seq_BREAST_Human1.16390853
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16369334
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16244383
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15829041
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14437358
81VDR_22108803_ChIP-Seq_LS180_Human1.13294035
82* MYB_26560356_Chip-Seq_TH1_Human1.12444846
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12382511
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11912081
85TP53_22573176_ChIP-Seq_HFKS_Human1.11262531
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10419026
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10359261
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.06078730
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05647873
90GATA3_27048872_Chip-Seq_THYMUS_Human1.05091324
91MAF_26560356_Chip-Seq_TH1_Human1.03074665
92STAT1_20625510_ChIP-Seq_HELA_Human1.01868495
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99829873
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99595480
95AR_20517297_ChIP-Seq_VCAP_Human0.97665044
96NANOG_20526341_ChIP-Seq_ESCs_Human0.97533849
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95339865
98* BCOR_27268052_Chip-Seq_Bcells_Human0.95203256
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94836798
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93437549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.31893958
2MP0001835_abnormal_antigen_presentation3.21681320
3MP0003724_increased_susceptibility_to2.80892474
4MP0003436_decreased_susceptibility_to2.80634915
5MP0003806_abnormal_nucleotide_metabolis2.74377175
6MP0001800_abnormal_humoral_immune2.56890852
7MP0001986_abnormal_taste_sensitivity2.51516569
8MP0005000_abnormal_immune_tolerance2.47317709
9MP0002723_abnormal_immune_serum2.39101765
10MP0003763_abnormal_thymus_physiology2.32376775
11MP0009785_altered_susceptibility_to2.30546189
12MP0001790_abnormal_immune_system2.26393278
13MP0005387_immune_system_phenotype2.26393278
14MP0002452_abnormal_antigen_presenting2.20476918
15MP0002420_abnormal_adaptive_immunity2.17699180
16MP0005075_abnormal_melanosome_morpholog2.16361205
17MP0001819_abnormal_immune_cell2.15728373
18MP0009333_abnormal_splenocyte_physiolog2.14976891
19MP0002148_abnormal_hypersensitivity_rea2.14254149
20MP0003786_premature_aging2.12068257
21MP0000685_abnormal_immune_system2.09678328
22MP0000372_irregular_coat_pigmentation2.03982491
23MP0005025_abnormal_response_to2.00334694
24MP0002419_abnormal_innate_immunity1.93376361
25MP0009764_decreased_sensitivity_to1.84211434
26MP0008058_abnormal_DNA_repair1.81942671
27MP0003195_calcinosis1.76717829
28MP0002398_abnormal_bone_marrow1.72977852
29MP0000689_abnormal_spleen_morphology1.71526667
30MP0000716_abnormal_immune_system1.69502153
31MP0006035_abnormal_mitochondrial_morpho1.68365387
32MP0008995_early_reproductive_senescence1.65093871
33MP0006036_abnormal_mitochondrial_physio1.61040446
34MP0009278_abnormal_bone_marrow1.60128761
35MP0002405_respiratory_system_inflammati1.59748968
36MP0002102_abnormal_ear_morphology1.58045252
37MP0001845_abnormal_inflammatory_respons1.56662185
38MP0005084_abnormal_gallbladder_morpholo1.54790416
39MP0003011_delayed_dark_adaptation1.53187912
40MP0001853_heart_inflammation1.53012029
41MP0001545_abnormal_hematopoietic_system1.51702548
42MP0005397_hematopoietic_system_phenotyp1.51702548
43MP0002722_abnormal_immune_system1.49107860
44MP0006072_abnormal_retinal_apoptosis1.48860516
45MP0005464_abnormal_platelet_physiology1.48466120
46MP0001873_stomach_inflammation1.46616992
47MP0002429_abnormal_blood_cell1.43955148
48MP0008469_abnormal_protein_level1.39504334
49MP0005310_abnormal_salivary_gland1.37201167
50MP0001533_abnormal_skeleton_physiology1.34237658
51MP0003880_abnormal_central_pattern1.33969645
52MP0003646_muscle_fatigue1.32459777
53MP0002277_abnormal_respiratory_mucosa1.26286966
54MP0002396_abnormal_hematopoietic_system1.20662209
55MP0000465_gastrointestinal_hemorrhage1.19982459
56MP0003866_abnormal_defecation1.19787757
57MP0010155_abnormal_intestine_physiology1.19461793
58MP0008872_abnormal_physiological_respon1.17463865
59MP0009379_abnormal_foot_pigmentation1.16592103
60MP0010094_abnormal_chromosome_stability1.12580159
61MP0000703_abnormal_thymus_morphology1.12522544
62MP0002095_abnormal_skin_pigmentation1.08012869
63MP0005645_abnormal_hypothalamus_physiol1.06809994
64MP0003186_abnormal_redox_activity1.05443440
65MP0002132_abnormal_respiratory_system1.04436808
66MP0000015_abnormal_ear_pigmentation1.01943716
67MP0003303_peritoneal_inflammation1.01103905
68MP0001764_abnormal_homeostasis1.00548009
69MP0006082_CNS_inflammation0.98886839
70MP0002933_joint_inflammation0.97280590
71MP0005646_abnormal_pituitary_gland0.96618965
72MP0002653_abnormal_ependyma_morphology0.96512056
73MP0005174_abnormal_tail_pigmentation0.95316202
74MP0008007_abnormal_cellular_replicative0.94515764
75MP0003693_abnormal_embryo_hatching0.90983137
76MP0008875_abnormal_xenobiotic_pharmacok0.90099372
77MP0002019_abnormal_tumor_incidence0.89073949
78MP0008057_abnormal_DNA_replication0.88230952
79MP0001663_abnormal_digestive_system0.85872964
80MP0004947_skin_inflammation0.85539278
81MP0000358_abnormal_cell_content/0.84849753
82MP0009763_increased_sensitivity_to0.82749779
83MP0004147_increased_porphyrin_level0.80210094
84MP0009765_abnormal_xenobiotic_induced0.79508424
85MP0006292_abnormal_olfactory_placode0.79004543
86MP0002166_altered_tumor_susceptibility0.78569575
87MP0002006_tumorigenesis0.75562069
88MP0005253_abnormal_eye_physiology0.75389560
89MP0001919_abnormal_reproductive_system0.75058625
90MP0008877_abnormal_DNA_methylation0.74516538
91MP0009697_abnormal_copulation0.72568832
92MP0005551_abnormal_eye_electrophysiolog0.69249543
93MP0003718_maternal_effect0.68850302
94MP0004381_abnormal_hair_follicle0.67272954
95MP0002138_abnormal_hepatobiliary_system0.65180090
96MP0000343_altered_response_to0.65032092
97MP0000490_abnormal_crypts_of0.64954753
98MP0002693_abnormal_pancreas_physiology0.64756391
99MP0008789_abnormal_olfactory_epithelium0.63071546
100MP0005376_homeostasis/metabolism_phenot0.62642995

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)4.23766249
2Mitochondrial inheritance (HP:0001427)4.20783604
3Hepatocellular necrosis (HP:0001404)3.91042777
4Acute necrotizing encephalopathy (HP:0006965)3.78328659
5Elevated erythrocyte sedimentation rate (HP:0003565)3.68661069
6Abnormal mitochondria in muscle tissue (HP:0008316)3.68035863
7Increased CSF lactate (HP:0002490)3.60115116
8Increased hepatocellular lipid droplets (HP:0006565)3.54759503
9Hepatic necrosis (HP:0002605)3.38659406
10Increased muscle lipid content (HP:0009058)3.27103489
11Panhypogammaglobulinemia (HP:0003139)3.21483504
12Acute encephalopathy (HP:0006846)3.17700408
13Progressive macrocephaly (HP:0004481)3.13220475
14Stomatitis (HP:0010280)3.12176207
15Aplastic anemia (HP:0001915)3.09864909
16Severe combined immunodeficiency (HP:0004430)3.01591467
17Myositis (HP:0100614)2.98665272
18Recurrent fungal infections (HP:0002841)2.95060278
19Recurrent cutaneous fungal infections (HP:0011370)2.92226618
20Chronic mucocutaneous candidiasis (HP:0002728)2.92226618
21Increased intramyocellular lipid droplets (HP:0012240)2.92034742
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87207228
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86131108
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86131108
253-Methylglutaconic aciduria (HP:0003535)2.81642675
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.79743144
27Renal Fanconi syndrome (HP:0001994)2.78436220
28Methylmalonic aciduria (HP:0012120)2.75515871
29Agammaglobulinemia (HP:0004432)2.74549231
30Abnormal number of erythroid precursors (HP:0012131)2.72651034
31Retrobulbar optic neuritis (HP:0100654)2.71406589
32Optic neuritis (HP:0100653)2.71406589
33IgG deficiency (HP:0004315)2.63519015
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.60838216
35Meningitis (HP:0001287)2.60391489
36Exertional dyspnea (HP:0002875)2.58835181
37Congenital, generalized hypertrichosis (HP:0004540)2.58384032
38Increased serum lactate (HP:0002151)2.56205881
39Orchitis (HP:0100796)2.55777030
40Petechiae (HP:0000967)2.50966108
41Lactic acidosis (HP:0003128)2.48882270
42Mediastinal lymphadenopathy (HP:0100721)2.48782531
43Stomach cancer (HP:0012126)2.44721706
44Abnormality of T cell physiology (HP:0011840)2.43330519
45Combined immunodeficiency (HP:0005387)2.42285820
46Pancreatic cysts (HP:0001737)2.40074372
47Abnormality of T cells (HP:0002843)2.37395584
48Recurrent abscess formation (HP:0002722)2.35778428
49Granulocytopenia (HP:0001913)2.35039275
50Dicarboxylic aciduria (HP:0003215)2.32139599
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32139599
52Abnormality of B cell number (HP:0010975)2.28987619
53Encephalitis (HP:0002383)2.28929848
54Abnormality of cells of the erythroid lineage (HP:0012130)2.27193304
55Methylmalonic acidemia (HP:0002912)2.26454658
56Neutropenia (HP:0001875)2.25775745
57Obstructive lung disease (HP:0006536)2.25586093
58Chronic obstructive pulmonary disease (HP:0006510)2.25586093
59Pancytopenia (HP:0001876)2.23771854
60Respiratory failure (HP:0002878)2.23531674
61Increased IgM level (HP:0003496)2.20791384
62Cerebral edema (HP:0002181)2.20454852
63Abnormality of midbrain morphology (HP:0002418)2.19756244
64Molar tooth sign on MRI (HP:0002419)2.19756244
65Colon cancer (HP:0003003)2.19079533
66Optic disc pallor (HP:0000543)2.18714185
67Eczematoid dermatitis (HP:0000976)2.16765724
68Hemoptysis (HP:0002105)2.15884528
69Exercise intolerance (HP:0003546)2.14374687
70Recurrent bacterial skin infections (HP:0005406)2.13926306
71Leukocytosis (HP:0001974)2.12225171
72Abnormality of eosinophils (HP:0001879)2.10327106
73Eosinophilia (HP:0001880)2.07414637
74Recurrent skin infections (HP:0001581)2.06959444
75Pancreatic fibrosis (HP:0100732)2.06643725
76Respiratory difficulties (HP:0002880)2.04231731
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04217840
78Abnormality of T cell number (HP:0011839)2.01050713
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00908132
80Abnormal protein N-linked glycosylation (HP:0012347)2.00908132
81Abnormal protein glycosylation (HP:0012346)2.00908132
82Abnormal glycosylation (HP:0012345)2.00908132
83Congenital stationary night blindness (HP:0007642)1.98952466
84Type I transferrin isoform profile (HP:0003642)1.98467413
85Large for gestational age (HP:0001520)1.98077838
86True hermaphroditism (HP:0010459)1.93321819
87Recurrent viral infections (HP:0004429)1.90995887
88Recurrent bronchitis (HP:0002837)1.90008406
89Vasculitis (HP:0002633)1.86937692
90T lymphocytopenia (HP:0005403)1.86565954
91Lethargy (HP:0001254)1.83919930
92Abnormality of the prostate (HP:0008775)1.82811795
93Microvesicular hepatic steatosis (HP:0001414)1.81376560
94Pallor (HP:0000980)1.81214602
95Parakeratosis (HP:0001036)1.79795025
96Medial flaring of the eyebrow (HP:0010747)1.79556810
97Abnormality of the pleura (HP:0002103)1.78522524
98Keratoconjunctivitis sicca (HP:0001097)1.76298204
99Keratoconjunctivitis (HP:0001096)1.76088661
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74742708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.82421369
2TXK3.27614111
3ERN13.13555790
4STK162.91420427
5MAP4K12.50793529
6NUAK12.50023640
7TAOK32.27050349
8ADRBK22.24975084
9VRK12.24903051
10TESK22.18106650
11SRPK12.06973911
12TLK12.02815101
13MST41.95773619
14IKBKE1.93624623
15ZAK1.90049913
16BLK1.83355640
17GRK61.82221380
18TBK11.72429185
19KDR1.70550904
20IKBKB1.69799739
21MAP4K21.68128416
22EIF2AK31.45601131
23BUB11.42970620
24TNK21.39949194
25KIT1.39196007
26GRK71.38843913
27STK101.36813939
28SYK1.36077789
29TYK21.30306868
30NME21.21241787
31NLK1.20381253
32DYRK21.19613653
33MAP3K111.18857741
34TEC1.17822760
35IRAK41.13977435
36MATK1.11426029
37MAP3K121.11076145
38MARK31.10982485
39PIM21.09310431
40BMPR1B1.08483118
41MAP2K21.07975636
42ZAP701.04310791
43LYN1.03786712
44EIF2AK11.00779274
45BCKDK0.98259814
46FRK0.95892509
47MAP2K30.94781673
48FES0.93869179
49ADRBK10.93613068
50CSNK1G30.92753287
51PINK10.92407780
52CSF1R0.84513041
53RPS6KA50.81148018
54MAP3K140.79228212
55CDK80.78975760
56CSNK1A1L0.78711489
57ITK0.75769969
58DAPK10.73849326
59EIF2AK20.72843148
60BTK0.72237009
61CDC70.71809858
62LCK0.71413168
63PASK0.70219624
64CSNK1G10.66357433
65HCK0.66083020
66JAK30.64134379
67RIPK40.60584098
68MAP2K60.59804367
69PDK20.59549505
70INSRR0.59052452
71CHUK0.58772930
72IRAK10.57332934
73ATR0.56410809
74WNK30.55801488
75IRAK20.54801422
76PRKCQ0.53622276
77TESK10.53432458
78GRK10.53310250
79CSNK1G20.53116299
80PIM10.50989667
81PRKCI0.46803907
82PLK30.46164302
83TNIK0.44095041
84EPHA30.43966234
85BMPR20.42713181
86STK40.42248311
87LRRK20.41499193
88IRAK30.40093254
89DYRK30.39145833
90PBK0.39114585
91AURKA0.37667481
92NME10.36374358
93CSNK2A10.35199165
94AURKB0.34104995
95CSK0.33491642
96TAOK20.33130363
97ILK0.32437835
98ABL10.31842911
99MAPK130.31457835
100CAMKK20.30327142

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.65106765
2Oxidative phosphorylation_Homo sapiens_hsa001903.21216080
3Ribosome_Homo sapiens_hsa030102.94484028
4Asthma_Homo sapiens_hsa053102.92539602
5RNA polymerase_Homo sapiens_hsa030202.88309697
6Parkinsons disease_Homo sapiens_hsa050122.84070962
7Primary immunodeficiency_Homo sapiens_hsa053402.82666726
8Allograft rejection_Homo sapiens_hsa053302.82422745
9Autoimmune thyroid disease_Homo sapiens_hsa053202.70072682
10Graft-versus-host disease_Homo sapiens_hsa053322.65831617
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.44255382
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28655607
13Protein export_Homo sapiens_hsa030602.27679023
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25370710
15Homologous recombination_Homo sapiens_hsa034402.15039303
16Type I diabetes mellitus_Homo sapiens_hsa049402.09673935
17DNA replication_Homo sapiens_hsa030302.07826764
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95143456
19Antigen processing and presentation_Homo sapiens_hsa046121.92670719
20Huntingtons disease_Homo sapiens_hsa050161.86477422
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83153003
22Base excision repair_Homo sapiens_hsa034101.74011505
23Alzheimers disease_Homo sapiens_hsa050101.68378095
24Mismatch repair_Homo sapiens_hsa034301.62575282
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47584883
26Rheumatoid arthritis_Homo sapiens_hsa053231.46539423
27Staphylococcus aureus infection_Homo sapiens_hsa051501.41996969
28Pyrimidine metabolism_Homo sapiens_hsa002401.39888244
29Leishmaniasis_Homo sapiens_hsa051401.33707971
30Viral myocarditis_Homo sapiens_hsa054161.28413578
31Spliceosome_Homo sapiens_hsa030401.26796089
32Hematopoietic cell lineage_Homo sapiens_hsa046401.24775322
33Fanconi anemia pathway_Homo sapiens_hsa034601.23575896
34Non-homologous end-joining_Homo sapiens_hsa034501.17909788
35Sulfur relay system_Homo sapiens_hsa041221.16152831
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12598347
37Systemic lupus erythematosus_Homo sapiens_hsa053221.10208040
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09825390
39Purine metabolism_Homo sapiens_hsa002301.06585027
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.00955704
41Herpes simplex infection_Homo sapiens_hsa051680.97705624
42Epstein-Barr virus infection_Homo sapiens_hsa051690.97253154
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91059192
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89426276
45Basal transcription factors_Homo sapiens_hsa030220.87101690
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84185675
47RNA degradation_Homo sapiens_hsa030180.82061877
48One carbon pool by folate_Homo sapiens_hsa006700.79183204
49Nucleotide excision repair_Homo sapiens_hsa034200.75397410
50Phototransduction_Homo sapiens_hsa047440.73209907
51Tuberculosis_Homo sapiens_hsa051520.72681017
52Collecting duct acid secretion_Homo sapiens_hsa049660.71725477
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70755039
54RNA transport_Homo sapiens_hsa030130.69994771
55Caffeine metabolism_Homo sapiens_hsa002320.69457125
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67901937
57Regulation of autophagy_Homo sapiens_hsa041400.67542114
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66909961
59Nitrogen metabolism_Homo sapiens_hsa009100.60989346
60Glutathione metabolism_Homo sapiens_hsa004800.59326716
61Cardiac muscle contraction_Homo sapiens_hsa042600.59088071
62Sulfur metabolism_Homo sapiens_hsa009200.58822390
63Peroxisome_Homo sapiens_hsa041460.58465486
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56796463
65Fatty acid elongation_Homo sapiens_hsa000620.56790964
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.55656427
67Legionellosis_Homo sapiens_hsa051340.55507631
68Tryptophan metabolism_Homo sapiens_hsa003800.55033183
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54161270
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53333415
71Osteoclast differentiation_Homo sapiens_hsa043800.51551425
72Folate biosynthesis_Homo sapiens_hsa007900.51177268
73Butanoate metabolism_Homo sapiens_hsa006500.50796514
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49831549
75Measles_Homo sapiens_hsa051620.48150965
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47963339
77Arachidonic acid metabolism_Homo sapiens_hsa005900.47111929
78Metabolic pathways_Homo sapiens_hsa011000.47059178
79Toxoplasmosis_Homo sapiens_hsa051450.45578369
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45526922
81Phagosome_Homo sapiens_hsa041450.44572013
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44499743
83Shigellosis_Homo sapiens_hsa051310.43301535
84Influenza A_Homo sapiens_hsa051640.41680378
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.38775237
86Malaria_Homo sapiens_hsa051440.36901333
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.35584330
88T cell receptor signaling pathway_Homo sapiens_hsa046600.34244344
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.32212880
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30208040
91Linoleic acid metabolism_Homo sapiens_hsa005910.29617378
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29512885
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29469383
94Chemical carcinogenesis_Homo sapiens_hsa052040.28651608
95Olfactory transduction_Homo sapiens_hsa047400.28531173
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27556518
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27510562
98p53 signaling pathway_Homo sapiens_hsa041150.25246044
99HTLV-I infection_Homo sapiens_hsa051660.24307231
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23263386

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