

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 4.95222271 |
| 2 | protein complex biogenesis (GO:0070271) | 4.17170660 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.15133300 |
| 4 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.08519422 |
| 5 | ATP synthesis coupled proton transport (GO:0015986) | 4.06111281 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.06111281 |
| 7 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.87981086 |
| 8 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.81555614 |
| 9 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.81555614 |
| 10 | NADH dehydrogenase complex assembly (GO:0010257) | 3.81555614 |
| 11 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.69619605 |
| 12 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.40339595 |
| 13 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.39793652 |
| 14 | platelet dense granule organization (GO:0060155) | 3.37447001 |
| 15 | immunoglobulin mediated immune response (GO:0016064) | 3.30093875 |
| 16 | base-excision repair, AP site formation (GO:0006285) | 3.29849659 |
| 17 | electron transport chain (GO:0022900) | 3.26637445 |
| 18 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.25415242 |
| 19 | regulation of mitochondrial translation (GO:0070129) | 3.24842330 |
| 20 | respiratory electron transport chain (GO:0022904) | 3.23414927 |
| 21 | negative regulation of B cell apoptotic process (GO:0002903) | 3.15420040 |
| 22 | proteasome assembly (GO:0043248) | 3.13639745 |
| 23 | cytochrome complex assembly (GO:0017004) | 3.13133022 |
| 24 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.12807062 |
| 25 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.12662350 |
| 26 | response to interferon-beta (GO:0035456) | 3.11728569 |
| 27 | inner mitochondrial membrane organization (GO:0007007) | 3.10134252 |
| 28 | chaperone-mediated protein transport (GO:0072321) | 3.08957966 |
| 29 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.07251045 |
| 30 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.07251045 |
| 31 | deoxyribonucleotide catabolic process (GO:0009264) | 3.07146865 |
| 32 | cellular response to interferon-beta (GO:0035458) | 2.98914579 |
| 33 | tryptophan catabolic process (GO:0006569) | 2.98899512 |
| 34 | indole-containing compound catabolic process (GO:0042436) | 2.98899512 |
| 35 | indolalkylamine catabolic process (GO:0046218) | 2.98899512 |
| 36 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.94817026 |
| 37 | termination of RNA polymerase III transcription (GO:0006386) | 2.94817026 |
| 38 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.94253369 |
| 39 | respiratory chain complex IV assembly (GO:0008535) | 2.87875983 |
| 40 | deoxyribose phosphate catabolic process (GO:0046386) | 2.86364625 |
| 41 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.86343339 |
| 42 | sequestering of actin monomers (GO:0042989) | 2.83855737 |
| 43 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.83643873 |
| 44 | B cell mediated immunity (GO:0019724) | 2.80662416 |
| 45 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.80501074 |
| 46 | ubiquinone biosynthetic process (GO:0006744) | 2.79490335 |
| 47 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.78022271 |
| 48 | positive regulation of granulocyte differentiation (GO:0030854) | 2.75479382 |
| 49 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.75112754 |
| 50 | viral transcription (GO:0019083) | 2.72162689 |
| 51 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.71819629 |
| 52 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.71819629 |
| 53 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.71819629 |
| 54 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.71179723 |
| 55 | positive regulation of defense response to virus by host (GO:0002230) | 2.70299133 |
| 56 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.70261058 |
| 57 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.70261058 |
| 58 | GPI anchor biosynthetic process (GO:0006506) | 2.67139030 |
| 59 | tryptophan metabolic process (GO:0006568) | 2.65625505 |
| 60 | kynurenine metabolic process (GO:0070189) | 2.63477097 |
| 61 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.61749575 |
| 62 | translational termination (GO:0006415) | 2.61731602 |
| 63 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.60896465 |
| 64 | ubiquinone metabolic process (GO:0006743) | 2.60840320 |
| 65 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.60778839 |
| 66 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.60751606 |
| 67 | peptidyl-histidine modification (GO:0018202) | 2.59911854 |
| 68 | cotranslational protein targeting to membrane (GO:0006613) | 2.59579083 |
| 69 | negative regulation of ligase activity (GO:0051352) | 2.59520156 |
| 70 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.59520156 |
| 71 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 2.59187320 |
| 72 | positive regulation of prostaglandin secretion (GO:0032308) | 2.59131619 |
| 73 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.58727536 |
| 74 | cytidine deamination (GO:0009972) | 2.58134575 |
| 75 | cytidine metabolic process (GO:0046087) | 2.58134575 |
| 76 | cytidine catabolic process (GO:0006216) | 2.58134575 |
| 77 | metallo-sulfur cluster assembly (GO:0031163) | 2.56966169 |
| 78 | iron-sulfur cluster assembly (GO:0016226) | 2.56966169 |
| 79 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.56839513 |
| 80 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.56839513 |
| 81 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.56309679 |
| 82 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.56210380 |
| 83 | establishment of viral latency (GO:0019043) | 2.55797300 |
| 84 | regulation of B cell apoptotic process (GO:0002902) | 2.54667346 |
| 85 | protein targeting to ER (GO:0045047) | 2.53685671 |
| 86 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.53068575 |
| 87 | protein targeting to mitochondrion (GO:0006626) | 2.51596693 |
| 88 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.49062499 |
| 89 | defense response to protozoan (GO:0042832) | 2.47550586 |
| 90 | maturation of 5.8S rRNA (GO:0000460) | 2.46972483 |
| 91 | spliceosomal snRNP assembly (GO:0000387) | 2.46581063 |
| 92 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.45314024 |
| 93 | GPI anchor metabolic process (GO:0006505) | 2.44627143 |
| 94 | establishment of protein localization to mitochondrion (GO:0072655) | 2.43291586 |
| 95 | ribosomal large subunit biogenesis (GO:0042273) | 2.42799144 |
| 96 | protein localization to endoplasmic reticulum (GO:0070972) | 2.41699829 |
| 97 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.39208612 |
| 98 | C-terminal protein lipidation (GO:0006501) | 2.39040843 |
| 99 | mitochondrial calcium ion transport (GO:0006851) | 2.38361754 |
| 100 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.37713594 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.04452509 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.89463336 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.73279555 |
| 4 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.46871622 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.33747753 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.27171542 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.23151621 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.95146293 |
| 9 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.86293701 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.79548270 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.71919383 |
| 12 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.60075754 |
| 13 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.56384543 |
| 14 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.48550489 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.48517275 |
| 16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.44971573 |
| 17 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.39398202 |
| 18 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.35144284 |
| 19 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.22180689 |
| 20 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.18657502 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.18484662 |
| 22 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.15055236 |
| 23 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.12642877 |
| 24 | CIITA_25753668_ChIP-Seq_RAJI_Human | 2.08761849 |
| 25 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.02847567 |
| 26 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.00869732 |
| 27 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.90586177 |
| 28 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.90194821 |
| 29 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.87647410 |
| 30 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.86821950 |
| 31 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.86023337 |
| 32 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.83873627 |
| 33 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.82209913 |
| 34 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.80153371 |
| 35 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.75701943 |
| 36 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.74758998 |
| 37 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.74463387 |
| 38 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.71938136 |
| 39 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.69063483 |
| 40 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.65054024 |
| 41 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.60445087 |
| 42 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.58984532 |
| 43 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.58034379 |
| 44 | MYB_26560356_Chip-Seq_TH2_Human | 1.54454913 |
| 45 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.53861101 |
| 46 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 1.51993513 |
| 47 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.49391251 |
| 48 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.49172931 |
| 49 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.48599002 |
| 50 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.44439316 |
| 51 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.43435239 |
| 52 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.42902214 |
| 53 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.40960471 |
| 54 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.40444600 |
| 55 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.40369621 |
| 56 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.37470630 |
| 57 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.35218845 |
| 58 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.34858846 |
| 59 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.34278054 |
| 60 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.33204338 |
| 61 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32054593 |
| 62 | GATA3_26560356_Chip-Seq_TH2_Human | 1.31622333 |
| 63 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.30257187 |
| 64 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.27452803 |
| 65 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.26966905 |
| 66 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.25607243 |
| 67 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.23164315 |
| 68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.23106524 |
| 69 | UTX_26944678_Chip-Seq_JUKART_Human | 1.20905953 |
| 70 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.20076815 |
| 71 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.19600260 |
| 72 | * P300_27268052_Chip-Seq_Bcells_Human | 1.19425439 |
| 73 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.18290013 |
| 74 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.18026122 |
| 75 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.16738259 |
| 76 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.16390853 |
| 77 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.16369334 |
| 78 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16244383 |
| 79 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.15829041 |
| 80 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.14437358 |
| 81 | VDR_22108803_ChIP-Seq_LS180_Human | 1.13294035 |
| 82 | * MYB_26560356_Chip-Seq_TH1_Human | 1.12444846 |
| 83 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.12382511 |
| 84 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.11912081 |
| 85 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.11262531 |
| 86 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.10419026 |
| 87 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.10359261 |
| 88 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.06078730 |
| 89 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.05647873 |
| 90 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.05091324 |
| 91 | MAF_26560356_Chip-Seq_TH1_Human | 1.03074665 |
| 92 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.01868495 |
| 93 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.99829873 |
| 94 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.99595480 |
| 95 | AR_20517297_ChIP-Seq_VCAP_Human | 0.97665044 |
| 96 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.97533849 |
| 97 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.95339865 |
| 98 | * BCOR_27268052_Chip-Seq_Bcells_Human | 0.95203256 |
| 99 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.94836798 |
| 100 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.93437549 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 3.31893958 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.21681320 |
| 3 | MP0003724_increased_susceptibility_to | 2.80892474 |
| 4 | MP0003436_decreased_susceptibility_to | 2.80634915 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 2.74377175 |
| 6 | MP0001800_abnormal_humoral_immune | 2.56890852 |
| 7 | MP0001986_abnormal_taste_sensitivity | 2.51516569 |
| 8 | MP0005000_abnormal_immune_tolerance | 2.47317709 |
| 9 | MP0002723_abnormal_immune_serum | 2.39101765 |
| 10 | MP0003763_abnormal_thymus_physiology | 2.32376775 |
| 11 | MP0009785_altered_susceptibility_to | 2.30546189 |
| 12 | MP0001790_abnormal_immune_system | 2.26393278 |
| 13 | MP0005387_immune_system_phenotype | 2.26393278 |
| 14 | MP0002452_abnormal_antigen_presenting | 2.20476918 |
| 15 | MP0002420_abnormal_adaptive_immunity | 2.17699180 |
| 16 | MP0005075_abnormal_melanosome_morpholog | 2.16361205 |
| 17 | MP0001819_abnormal_immune_cell | 2.15728373 |
| 18 | MP0009333_abnormal_splenocyte_physiolog | 2.14976891 |
| 19 | MP0002148_abnormal_hypersensitivity_rea | 2.14254149 |
| 20 | MP0003786_premature_aging | 2.12068257 |
| 21 | MP0000685_abnormal_immune_system | 2.09678328 |
| 22 | MP0000372_irregular_coat_pigmentation | 2.03982491 |
| 23 | MP0005025_abnormal_response_to | 2.00334694 |
| 24 | MP0002419_abnormal_innate_immunity | 1.93376361 |
| 25 | MP0009764_decreased_sensitivity_to | 1.84211434 |
| 26 | MP0008058_abnormal_DNA_repair | 1.81942671 |
| 27 | MP0003195_calcinosis | 1.76717829 |
| 28 | MP0002398_abnormal_bone_marrow | 1.72977852 |
| 29 | MP0000689_abnormal_spleen_morphology | 1.71526667 |
| 30 | MP0000716_abnormal_immune_system | 1.69502153 |
| 31 | MP0006035_abnormal_mitochondrial_morpho | 1.68365387 |
| 32 | MP0008995_early_reproductive_senescence | 1.65093871 |
| 33 | MP0006036_abnormal_mitochondrial_physio | 1.61040446 |
| 34 | MP0009278_abnormal_bone_marrow | 1.60128761 |
| 35 | MP0002405_respiratory_system_inflammati | 1.59748968 |
| 36 | MP0002102_abnormal_ear_morphology | 1.58045252 |
| 37 | MP0001845_abnormal_inflammatory_respons | 1.56662185 |
| 38 | MP0005084_abnormal_gallbladder_morpholo | 1.54790416 |
| 39 | MP0003011_delayed_dark_adaptation | 1.53187912 |
| 40 | MP0001853_heart_inflammation | 1.53012029 |
| 41 | MP0001545_abnormal_hematopoietic_system | 1.51702548 |
| 42 | MP0005397_hematopoietic_system_phenotyp | 1.51702548 |
| 43 | MP0002722_abnormal_immune_system | 1.49107860 |
| 44 | MP0006072_abnormal_retinal_apoptosis | 1.48860516 |
| 45 | MP0005464_abnormal_platelet_physiology | 1.48466120 |
| 46 | MP0001873_stomach_inflammation | 1.46616992 |
| 47 | MP0002429_abnormal_blood_cell | 1.43955148 |
| 48 | MP0008469_abnormal_protein_level | 1.39504334 |
| 49 | MP0005310_abnormal_salivary_gland | 1.37201167 |
| 50 | MP0001533_abnormal_skeleton_physiology | 1.34237658 |
| 51 | MP0003880_abnormal_central_pattern | 1.33969645 |
| 52 | MP0003646_muscle_fatigue | 1.32459777 |
| 53 | MP0002277_abnormal_respiratory_mucosa | 1.26286966 |
| 54 | MP0002396_abnormal_hematopoietic_system | 1.20662209 |
| 55 | MP0000465_gastrointestinal_hemorrhage | 1.19982459 |
| 56 | MP0003866_abnormal_defecation | 1.19787757 |
| 57 | MP0010155_abnormal_intestine_physiology | 1.19461793 |
| 58 | MP0008872_abnormal_physiological_respon | 1.17463865 |
| 59 | MP0009379_abnormal_foot_pigmentation | 1.16592103 |
| 60 | MP0010094_abnormal_chromosome_stability | 1.12580159 |
| 61 | MP0000703_abnormal_thymus_morphology | 1.12522544 |
| 62 | MP0002095_abnormal_skin_pigmentation | 1.08012869 |
| 63 | MP0005645_abnormal_hypothalamus_physiol | 1.06809994 |
| 64 | MP0003186_abnormal_redox_activity | 1.05443440 |
| 65 | MP0002132_abnormal_respiratory_system | 1.04436808 |
| 66 | MP0000015_abnormal_ear_pigmentation | 1.01943716 |
| 67 | MP0003303_peritoneal_inflammation | 1.01103905 |
| 68 | MP0001764_abnormal_homeostasis | 1.00548009 |
| 69 | MP0006082_CNS_inflammation | 0.98886839 |
| 70 | MP0002933_joint_inflammation | 0.97280590 |
| 71 | MP0005646_abnormal_pituitary_gland | 0.96618965 |
| 72 | MP0002653_abnormal_ependyma_morphology | 0.96512056 |
| 73 | MP0005174_abnormal_tail_pigmentation | 0.95316202 |
| 74 | MP0008007_abnormal_cellular_replicative | 0.94515764 |
| 75 | MP0003693_abnormal_embryo_hatching | 0.90983137 |
| 76 | MP0008875_abnormal_xenobiotic_pharmacok | 0.90099372 |
| 77 | MP0002019_abnormal_tumor_incidence | 0.89073949 |
| 78 | MP0008057_abnormal_DNA_replication | 0.88230952 |
| 79 | MP0001663_abnormal_digestive_system | 0.85872964 |
| 80 | MP0004947_skin_inflammation | 0.85539278 |
| 81 | MP0000358_abnormal_cell_content/ | 0.84849753 |
| 82 | MP0009763_increased_sensitivity_to | 0.82749779 |
| 83 | MP0004147_increased_porphyrin_level | 0.80210094 |
| 84 | MP0009765_abnormal_xenobiotic_induced | 0.79508424 |
| 85 | MP0006292_abnormal_olfactory_placode | 0.79004543 |
| 86 | MP0002166_altered_tumor_susceptibility | 0.78569575 |
| 87 | MP0002006_tumorigenesis | 0.75562069 |
| 88 | MP0005253_abnormal_eye_physiology | 0.75389560 |
| 89 | MP0001919_abnormal_reproductive_system | 0.75058625 |
| 90 | MP0008877_abnormal_DNA_methylation | 0.74516538 |
| 91 | MP0009697_abnormal_copulation | 0.72568832 |
| 92 | MP0005551_abnormal_eye_electrophysiolog | 0.69249543 |
| 93 | MP0003718_maternal_effect | 0.68850302 |
| 94 | MP0004381_abnormal_hair_follicle | 0.67272954 |
| 95 | MP0002138_abnormal_hepatobiliary_system | 0.65180090 |
| 96 | MP0000343_altered_response_to | 0.65032092 |
| 97 | MP0000490_abnormal_crypts_of | 0.64954753 |
| 98 | MP0002693_abnormal_pancreas_physiology | 0.64756391 |
| 99 | MP0008789_abnormal_olfactory_epithelium | 0.63071546 |
| 100 | MP0005376_homeostasis/metabolism_phenot | 0.62642995 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Lipid accumulation in hepatocytes (HP:0006561) | 4.23766249 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.20783604 |
| 3 | Hepatocellular necrosis (HP:0001404) | 3.91042777 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 3.78328659 |
| 5 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.68661069 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.68035863 |
| 7 | Increased CSF lactate (HP:0002490) | 3.60115116 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.54759503 |
| 9 | Hepatic necrosis (HP:0002605) | 3.38659406 |
| 10 | Increased muscle lipid content (HP:0009058) | 3.27103489 |
| 11 | Panhypogammaglobulinemia (HP:0003139) | 3.21483504 |
| 12 | Acute encephalopathy (HP:0006846) | 3.17700408 |
| 13 | Progressive macrocephaly (HP:0004481) | 3.13220475 |
| 14 | Stomatitis (HP:0010280) | 3.12176207 |
| 15 | Aplastic anemia (HP:0001915) | 3.09864909 |
| 16 | Severe combined immunodeficiency (HP:0004430) | 3.01591467 |
| 17 | Myositis (HP:0100614) | 2.98665272 |
| 18 | Recurrent fungal infections (HP:0002841) | 2.95060278 |
| 19 | Recurrent cutaneous fungal infections (HP:0011370) | 2.92226618 |
| 20 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.92226618 |
| 21 | Increased intramyocellular lipid droplets (HP:0012240) | 2.92034742 |
| 22 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.87207228 |
| 23 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.86131108 |
| 24 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.86131108 |
| 25 | 3-Methylglutaconic aciduria (HP:0003535) | 2.81642675 |
| 26 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.79743144 |
| 27 | Renal Fanconi syndrome (HP:0001994) | 2.78436220 |
| 28 | Methylmalonic aciduria (HP:0012120) | 2.75515871 |
| 29 | Agammaglobulinemia (HP:0004432) | 2.74549231 |
| 30 | Abnormal number of erythroid precursors (HP:0012131) | 2.72651034 |
| 31 | Optic neuritis (HP:0100653) | 2.71406589 |
| 32 | Retrobulbar optic neuritis (HP:0100654) | 2.71406589 |
| 33 | IgG deficiency (HP:0004315) | 2.63519015 |
| 34 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.60838216 |
| 35 | Meningitis (HP:0001287) | 2.60391489 |
| 36 | Exertional dyspnea (HP:0002875) | 2.58835181 |
| 37 | Congenital, generalized hypertrichosis (HP:0004540) | 2.58384032 |
| 38 | Increased serum lactate (HP:0002151) | 2.56205881 |
| 39 | Orchitis (HP:0100796) | 2.55777030 |
| 40 | Petechiae (HP:0000967) | 2.50966108 |
| 41 | Lactic acidosis (HP:0003128) | 2.48882270 |
| 42 | Mediastinal lymphadenopathy (HP:0100721) | 2.48782531 |
| 43 | Stomach cancer (HP:0012126) | 2.44721706 |
| 44 | Abnormality of T cell physiology (HP:0011840) | 2.43330519 |
| 45 | Combined immunodeficiency (HP:0005387) | 2.42285820 |
| 46 | Pancreatic cysts (HP:0001737) | 2.40074372 |
| 47 | Abnormality of T cells (HP:0002843) | 2.37395584 |
| 48 | Recurrent abscess formation (HP:0002722) | 2.35778428 |
| 49 | Granulocytopenia (HP:0001913) | 2.35039275 |
| 50 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.32139599 |
| 51 | Dicarboxylic aciduria (HP:0003215) | 2.32139599 |
| 52 | Abnormality of B cell number (HP:0010975) | 2.28987619 |
| 53 | Encephalitis (HP:0002383) | 2.28929848 |
| 54 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.27193304 |
| 55 | Methylmalonic acidemia (HP:0002912) | 2.26454658 |
| 56 | Neutropenia (HP:0001875) | 2.25775745 |
| 57 | Chronic obstructive pulmonary disease (HP:0006510) | 2.25586093 |
| 58 | Obstructive lung disease (HP:0006536) | 2.25586093 |
| 59 | Pancytopenia (HP:0001876) | 2.23771854 |
| 60 | Respiratory failure (HP:0002878) | 2.23531674 |
| 61 | Increased IgM level (HP:0003496) | 2.20791384 |
| 62 | Cerebral edema (HP:0002181) | 2.20454852 |
| 63 | Molar tooth sign on MRI (HP:0002419) | 2.19756244 |
| 64 | Abnormality of midbrain morphology (HP:0002418) | 2.19756244 |
| 65 | Colon cancer (HP:0003003) | 2.19079533 |
| 66 | Optic disc pallor (HP:0000543) | 2.18714185 |
| 67 | Eczematoid dermatitis (HP:0000976) | 2.16765724 |
| 68 | Hemoptysis (HP:0002105) | 2.15884528 |
| 69 | Exercise intolerance (HP:0003546) | 2.14374687 |
| 70 | Recurrent bacterial skin infections (HP:0005406) | 2.13926306 |
| 71 | Leukocytosis (HP:0001974) | 2.12225171 |
| 72 | Abnormality of eosinophils (HP:0001879) | 2.10327106 |
| 73 | Eosinophilia (HP:0001880) | 2.07414637 |
| 74 | Recurrent skin infections (HP:0001581) | 2.06959444 |
| 75 | Pancreatic fibrosis (HP:0100732) | 2.06643725 |
| 76 | Respiratory difficulties (HP:0002880) | 2.04231731 |
| 77 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.04217840 |
| 78 | Abnormality of T cell number (HP:0011839) | 2.01050713 |
| 79 | Abnormal protein glycosylation (HP:0012346) | 2.00908132 |
| 80 | Abnormal glycosylation (HP:0012345) | 2.00908132 |
| 81 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.00908132 |
| 82 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.00908132 |
| 83 | Congenital stationary night blindness (HP:0007642) | 1.98952466 |
| 84 | Type I transferrin isoform profile (HP:0003642) | 1.98467413 |
| 85 | Large for gestational age (HP:0001520) | 1.98077838 |
| 86 | True hermaphroditism (HP:0010459) | 1.93321819 |
| 87 | Recurrent viral infections (HP:0004429) | 1.90995887 |
| 88 | Recurrent bronchitis (HP:0002837) | 1.90008406 |
| 89 | Vasculitis (HP:0002633) | 1.86937692 |
| 90 | T lymphocytopenia (HP:0005403) | 1.86565954 |
| 91 | Lethargy (HP:0001254) | 1.83919930 |
| 92 | Abnormality of the prostate (HP:0008775) | 1.82811795 |
| 93 | Microvesicular hepatic steatosis (HP:0001414) | 1.81376560 |
| 94 | Pallor (HP:0000980) | 1.81214602 |
| 95 | Parakeratosis (HP:0001036) | 1.79795025 |
| 96 | Medial flaring of the eyebrow (HP:0010747) | 1.79556810 |
| 97 | Abnormality of the pleura (HP:0002103) | 1.78522524 |
| 98 | Keratoconjunctivitis sicca (HP:0001097) | 1.76298204 |
| 99 | Keratoconjunctivitis (HP:0001096) | 1.76088661 |
| 100 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.74742708 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.82421369 |
| 2 | TXK | 3.27614111 |
| 3 | ERN1 | 3.13555790 |
| 4 | STK16 | 2.91420427 |
| 5 | MAP4K1 | 2.50793529 |
| 6 | NUAK1 | 2.50023640 |
| 7 | TAOK3 | 2.27050349 |
| 8 | ADRBK2 | 2.24975084 |
| 9 | VRK1 | 2.24903051 |
| 10 | TESK2 | 2.18106650 |
| 11 | SRPK1 | 2.06973911 |
| 12 | TLK1 | 2.02815101 |
| 13 | MST4 | 1.95773619 |
| 14 | IKBKE | 1.93624623 |
| 15 | ZAK | 1.90049913 |
| 16 | BLK | 1.83355640 |
| 17 | GRK6 | 1.82221380 |
| 18 | TBK1 | 1.72429185 |
| 19 | KDR | 1.70550904 |
| 20 | IKBKB | 1.69799739 |
| 21 | MAP4K2 | 1.68128416 |
| 22 | EIF2AK3 | 1.45601131 |
| 23 | BUB1 | 1.42970620 |
| 24 | TNK2 | 1.39949194 |
| 25 | KIT | 1.39196007 |
| 26 | GRK7 | 1.38843913 |
| 27 | STK10 | 1.36813939 |
| 28 | SYK | 1.36077789 |
| 29 | TYK2 | 1.30306868 |
| 30 | NME2 | 1.21241787 |
| 31 | NLK | 1.20381253 |
| 32 | DYRK2 | 1.19613653 |
| 33 | MAP3K11 | 1.18857741 |
| 34 | TEC | 1.17822760 |
| 35 | IRAK4 | 1.13977435 |
| 36 | MATK | 1.11426029 |
| 37 | MAP3K12 | 1.11076145 |
| 38 | MARK3 | 1.10982485 |
| 39 | PIM2 | 1.09310431 |
| 40 | BMPR1B | 1.08483118 |
| 41 | MAP2K2 | 1.07975636 |
| 42 | ZAP70 | 1.04310791 |
| 43 | LYN | 1.03786712 |
| 44 | EIF2AK1 | 1.00779274 |
| 45 | BCKDK | 0.98259814 |
| 46 | FRK | 0.95892509 |
| 47 | MAP2K3 | 0.94781673 |
| 48 | FES | 0.93869179 |
| 49 | ADRBK1 | 0.93613068 |
| 50 | CSNK1G3 | 0.92753287 |
| 51 | PINK1 | 0.92407780 |
| 52 | CSF1R | 0.84513041 |
| 53 | RPS6KA5 | 0.81148018 |
| 54 | MAP3K14 | 0.79228212 |
| 55 | CDK8 | 0.78975760 |
| 56 | CSNK1A1L | 0.78711489 |
| 57 | ITK | 0.75769969 |
| 58 | DAPK1 | 0.73849326 |
| 59 | EIF2AK2 | 0.72843148 |
| 60 | BTK | 0.72237009 |
| 61 | CDC7 | 0.71809858 |
| 62 | LCK | 0.71413168 |
| 63 | PASK | 0.70219624 |
| 64 | CSNK1G1 | 0.66357433 |
| 65 | HCK | 0.66083020 |
| 66 | JAK3 | 0.64134379 |
| 67 | RIPK4 | 0.60584098 |
| 68 | MAP2K6 | 0.59804367 |
| 69 | PDK2 | 0.59549505 |
| 70 | INSRR | 0.59052452 |
| 71 | CHUK | 0.58772930 |
| 72 | IRAK1 | 0.57332934 |
| 73 | ATR | 0.56410809 |
| 74 | WNK3 | 0.55801488 |
| 75 | IRAK2 | 0.54801422 |
| 76 | PRKCQ | 0.53622276 |
| 77 | TESK1 | 0.53432458 |
| 78 | GRK1 | 0.53310250 |
| 79 | CSNK1G2 | 0.53116299 |
| 80 | PIM1 | 0.50989667 |
| 81 | PRKCI | 0.46803907 |
| 82 | PLK3 | 0.46164302 |
| 83 | TNIK | 0.44095041 |
| 84 | EPHA3 | 0.43966234 |
| 85 | BMPR2 | 0.42713181 |
| 86 | STK4 | 0.42248311 |
| 87 | LRRK2 | 0.41499193 |
| 88 | IRAK3 | 0.40093254 |
| 89 | DYRK3 | 0.39145833 |
| 90 | PBK | 0.39114585 |
| 91 | AURKA | 0.37667481 |
| 92 | NME1 | 0.36374358 |
| 93 | CSNK2A1 | 0.35199165 |
| 94 | AURKB | 0.34104995 |
| 95 | CSK | 0.33491642 |
| 96 | TAOK2 | 0.33130363 |
| 97 | ILK | 0.32437835 |
| 98 | ABL1 | 0.31842911 |
| 99 | MAPK13 | 0.31457835 |
| 100 | CAMKK2 | 0.30327142 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.65106765 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.21216080 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 2.94484028 |
| 4 | Asthma_Homo sapiens_hsa05310 | 2.92539602 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.88309697 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.84070962 |
| 7 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.82666726 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.82422745 |
| 9 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.70072682 |
| 10 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.65831617 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.44255382 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.28655607 |
| 13 | Protein export_Homo sapiens_hsa03060 | 2.27679023 |
| 14 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.25370710 |
| 15 | Homologous recombination_Homo sapiens_hsa03440 | 2.15039303 |
| 16 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.09673935 |
| 17 | DNA replication_Homo sapiens_hsa03030 | 2.07826764 |
| 18 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.95143456 |
| 19 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.92670719 |
| 20 | Huntingtons disease_Homo sapiens_hsa05016 | 1.86477422 |
| 21 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.83153003 |
| 22 | Base excision repair_Homo sapiens_hsa03410 | 1.74011505 |
| 23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.68378095 |
| 24 | Mismatch repair_Homo sapiens_hsa03430 | 1.62575282 |
| 25 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.47584883 |
| 26 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.46539423 |
| 27 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.41996969 |
| 28 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.39888244 |
| 29 | Leishmaniasis_Homo sapiens_hsa05140 | 1.33707971 |
| 30 | Viral myocarditis_Homo sapiens_hsa05416 | 1.28413578 |
| 31 | Spliceosome_Homo sapiens_hsa03040 | 1.26796089 |
| 32 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.24775322 |
| 33 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.23575896 |
| 34 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.17909788 |
| 35 | Sulfur relay system_Homo sapiens_hsa04122 | 1.16152831 |
| 36 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.12598347 |
| 37 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.10208040 |
| 38 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.09825390 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.06585027 |
| 40 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.00955704 |
| 41 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.97705624 |
| 42 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.97253154 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.91059192 |
| 44 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.89426276 |
| 45 | Basal transcription factors_Homo sapiens_hsa03022 | 0.87101690 |
| 46 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.84185675 |
| 47 | RNA degradation_Homo sapiens_hsa03018 | 0.82061877 |
| 48 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.79183204 |
| 49 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.75397410 |
| 50 | Phototransduction_Homo sapiens_hsa04744 | 0.73209907 |
| 51 | Tuberculosis_Homo sapiens_hsa05152 | 0.72681017 |
| 52 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.71725477 |
| 53 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.70755039 |
| 54 | RNA transport_Homo sapiens_hsa03013 | 0.69994771 |
| 55 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.69457125 |
| 56 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.67901937 |
| 57 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.67542114 |
| 58 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.66909961 |
| 59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.60989346 |
| 60 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.59326716 |
| 61 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.59088071 |
| 62 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.58822390 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.58465486 |
| 64 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.56796463 |
| 65 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.56790964 |
| 66 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.55656427 |
| 67 | Legionellosis_Homo sapiens_hsa05134 | 0.55507631 |
| 68 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.55033183 |
| 69 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.54161270 |
| 70 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.53333415 |
| 71 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.51551425 |
| 72 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.51177268 |
| 73 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.50796514 |
| 74 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.49831549 |
| 75 | Measles_Homo sapiens_hsa05162 | 0.48150965 |
| 76 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.47963339 |
| 77 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.47111929 |
| 78 | Metabolic pathways_Homo sapiens_hsa01100 | 0.47059178 |
| 79 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.45578369 |
| 80 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.45526922 |
| 81 | Phagosome_Homo sapiens_hsa04145 | 0.44572013 |
| 82 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.44499743 |
| 83 | Shigellosis_Homo sapiens_hsa05131 | 0.43301535 |
| 84 | Influenza A_Homo sapiens_hsa05164 | 0.41680378 |
| 85 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.38775237 |
| 86 | Malaria_Homo sapiens_hsa05144 | 0.36901333 |
| 87 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.35584330 |
| 88 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.34244344 |
| 89 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.32212880 |
| 90 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.30208040 |
| 91 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.29617378 |
| 92 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.29512885 |
| 93 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.29469383 |
| 94 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.28651608 |
| 95 | Olfactory transduction_Homo sapiens_hsa04740 | 0.28531173 |
| 96 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.27556518 |
| 97 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.27510562 |
| 98 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.25246044 |
| 99 | HTLV-I infection_Homo sapiens_hsa05166 | 0.24307231 |
| 100 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.23263386 |

