POLR2K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.09515871
2ATP synthesis coupled proton transport (GO:0015986)6.92305962
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.92305962
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.32634026
5protein neddylation (GO:0045116)5.71826158
6ribosomal small subunit biogenesis (GO:0042274)5.55326656
7respiratory electron transport chain (GO:0022904)5.47332786
8electron transport chain (GO:0022900)5.33140065
9chaperone-mediated protein transport (GO:0072321)5.15483045
10proteasome assembly (GO:0043248)5.03705744
11axon ensheathment in central nervous system (GO:0032291)4.68354893
12central nervous system myelination (GO:0022010)4.68354893
13viral transcription (GO:0019083)4.56792164
14GTP biosynthetic process (GO:0006183)4.55290201
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.48448947
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.48279579
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.48279579
18NADH dehydrogenase complex assembly (GO:0010257)4.48279579
19cotranslational protein targeting to membrane (GO:0006613)4.43973823
20translational termination (GO:0006415)4.40769107
21protein complex biogenesis (GO:0070271)4.34531710
22protein targeting to ER (GO:0045047)4.33184967
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.32430186
24protein localization to endoplasmic reticulum (GO:0070972)4.16174334
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.14624064
26maturation of SSU-rRNA (GO:0030490)4.13275660
27* termination of RNA polymerase III transcription (GO:0006386)4.08194978
28* transcription elongation from RNA polymerase III promoter (GO:0006385)4.08194978
29ribosomal small subunit assembly (GO:0000028)4.03995131
30mitochondrial respiratory chain complex assembly (GO:0033108)3.93586085
31CENP-A containing nucleosome assembly (GO:0034080)3.84985981
32chromatin remodeling at centromere (GO:0031055)3.79129218
33* RNA capping (GO:0036260)3.77980761
34* 7-methylguanosine RNA capping (GO:0009452)3.77980761
35ribosomal large subunit biogenesis (GO:0042273)3.77174833
36* 7-methylguanosine mRNA capping (GO:0006370)3.76680893
37UTP biosynthetic process (GO:0006228)3.75022246
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67494006
39positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.64801681
40establishment of integrated proviral latency (GO:0075713)3.62887935
41guanosine-containing compound biosynthetic process (GO:1901070)3.59537369
42rRNA modification (GO:0000154)3.57945901
43translation (GO:0006412)3.57055683
44cytochrome complex assembly (GO:0017004)3.53943086
45viral life cycle (GO:0019058)3.52640167
46protein targeting to mitochondrion (GO:0006626)3.52588585
47translational elongation (GO:0006414)3.52515055
48cellular protein complex disassembly (GO:0043624)3.50945764
49regulation of cellular amino acid metabolic process (GO:0006521)3.50050939
50positive regulation of ligase activity (GO:0051351)3.49672949
51establishment of viral latency (GO:0019043)3.47934455
52inner mitochondrial membrane organization (GO:0007007)3.47337613
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.46411813
54oxidative phosphorylation (GO:0006119)3.46314521
55fatty acid elongation (GO:0030497)3.46159663
56peptidyl-histidine modification (GO:0018202)3.45261377
57negative regulation of ligase activity (GO:0051352)3.42404893
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.42404893
59long-chain fatty acid biosynthetic process (GO:0042759)3.40437750
60establishment of protein localization to mitochondrion (GO:0072655)3.40197393
61purine nucleoside triphosphate biosynthetic process (GO:0009145)3.38687574
62hydrogen ion transmembrane transport (GO:1902600)3.37910137
63water-soluble vitamin biosynthetic process (GO:0042364)3.37853706
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36919404
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34710192
66DNA double-strand break processing (GO:0000729)3.34349496
67DNA deamination (GO:0045006)3.33972247
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.32444443
69protein K6-linked ubiquitination (GO:0085020)3.30606463
70protein-cofactor linkage (GO:0018065)3.29781515
71maturation of 5.8S rRNA (GO:0000460)3.28807134
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27121094
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27121094
74regulation of mitochondrial translation (GO:0070129)3.26291640
75translational initiation (GO:0006413)3.25929693
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25184027
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25184027
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25184027
79regulation of ubiquitin-protein transferase activity (GO:0051438)3.24854780
80spliceosomal snRNP assembly (GO:0000387)3.23979130
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23967878
82intracellular protein transmembrane import (GO:0044743)3.23560013
83GPI anchor biosynthetic process (GO:0006506)3.23467827
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20680468
85organelle disassembly (GO:1903008)3.20488581
86CTP metabolic process (GO:0046036)3.19295097
87CTP biosynthetic process (GO:0006241)3.19295097
88cullin deneddylation (GO:0010388)3.17738704
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17660338
90ATP biosynthetic process (GO:0006754)3.15303703
91regulation of ligase activity (GO:0051340)3.13854966
92signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13740404
93signal transduction involved in DNA damage checkpoint (GO:0072422)3.13740404
94histone exchange (GO:0043486)3.12846728
95protein localization to mitochondrion (GO:0070585)3.12241381
96signal transduction involved in cell cycle checkpoint (GO:0072395)3.12040840
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09858612
98proton transport (GO:0015992)3.09118779
99regulation of mitotic spindle checkpoint (GO:1903504)3.09078146
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.09078146
101mannosylation (GO:0097502)3.08870932
102respiratory chain complex IV assembly (GO:0008535)3.06892372
103pseudouridine synthesis (GO:0001522)3.06481850
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04256083
105cellular component biogenesis (GO:0044085)3.03479138
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02597149
107UTP metabolic process (GO:0046051)3.02401625
108ribonucleoside triphosphate biosynthetic process (GO:0009201)3.01562073
109DNA damage response, detection of DNA damage (GO:0042769)3.00052770
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99846291
111hydrogen transport (GO:0006818)2.99247075
112platelet dense granule organization (GO:0060155)2.98719324
113histone mRNA metabolic process (GO:0008334)2.94279157
114cholesterol biosynthetic process (GO:0006695)2.92944229
115* transcription elongation from RNA polymerase I promoter (GO:0006362)2.92232865
116protein deneddylation (GO:0000338)2.92105021
117sequestering of actin monomers (GO:0042989)2.91836187
118protein K11-linked ubiquitination (GO:0070979)2.91701535
119rRNA methylation (GO:0031167)2.91653836
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90801006
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90801006
122ribonucleoprotein complex biogenesis (GO:0022613)2.89542510
123preassembly of GPI anchor in ER membrane (GO:0016254)2.89367191
124spliceosomal complex assembly (GO:0000245)2.87569630
125regulation of cellular amine metabolic process (GO:0033238)2.87421144
126positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.86698742
127DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.86416327
128nucleoside diphosphate phosphorylation (GO:0006165)2.85755823
129substantia nigra development (GO:0021762)2.85113337
130mitochondrial transport (GO:0006839)2.84068922
131negative regulation of protein ubiquitination (GO:0031397)2.83806091
132isoprenoid biosynthetic process (GO:0008299)2.83415659
133ribonucleoprotein complex disassembly (GO:0032988)2.79359240
134DNA catabolic process, exonucleolytic (GO:0000738)2.78324919
135rRNA processing (GO:0006364)2.76525581
136positive regulation of cell cycle arrest (GO:0071158)2.75732140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.47691328
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.69891547
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.68829664
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.37443734
5* EST1_17652178_ChIP-ChIP_JURKAT_Human4.03141989
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.59876763
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37331992
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20689971
9* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.14136876
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08921626
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.05901002
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99452074
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82504973
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.54778150
15* ELK1_19687146_ChIP-ChIP_HELA_Human2.40654557
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.35564150
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35013152
18VDR_23849224_ChIP-Seq_CD4+_Human2.29285844
19VDR_22108803_ChIP-Seq_LS180_Human2.22185089
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13570017
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.13167875
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.11499974
23E2F7_22180533_ChIP-Seq_HELA_Human2.01455609
24TAF15_26573619_Chip-Seq_HEK293_Human1.96747851
25DCP1A_22483619_ChIP-Seq_HELA_Human1.91429506
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91204146
27FUS_26573619_Chip-Seq_HEK293_Human1.78428098
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72858523
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72165070
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67377961
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67371212
32FOXP3_21729870_ChIP-Seq_TREG_Human1.67019342
33IRF1_19129219_ChIP-ChIP_H3396_Human1.60166301
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59793892
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59533083
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.58464444
37ZNF274_21170338_ChIP-Seq_K562_Hela1.58317180
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56042762
39TTF2_22483619_ChIP-Seq_HELA_Human1.54677800
40* ELK1_22589737_ChIP-Seq_MCF10A_Human1.54382662
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52375967
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48216710
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47288049
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46313377
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.45500934
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43094554
47* XRN2_22483619_ChIP-Seq_HELA_Human1.41754595
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39133961
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38542312
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35245462
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34807796
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32961431
53ER_23166858_ChIP-Seq_MCF-7_Human1.32752248
54EWS_26573619_Chip-Seq_HEK293_Human1.30970964
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26675305
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25796071
57MYC_18940864_ChIP-ChIP_HL60_Human1.22840729
58AR_21909140_ChIP-Seq_LNCAP_Human1.22810062
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20630588
60GABP_19822575_ChIP-Seq_HepG2_Human1.19208200
61* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15244603
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13990770
63* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13857427
64IGF1R_20145208_ChIP-Seq_DFB_Human1.12897357
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.12482134
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11537832
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10379470
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.09735690
69TP53_22573176_ChIP-Seq_HFKS_Human1.09425737
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.09019670
71* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08849184
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07782478
73GBX2_23144817_ChIP-Seq_PC3_Human1.07775797
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07110667
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04901063
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02105600
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01320549
78P300_19829295_ChIP-Seq_ESCs_Human1.00777300
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00390325
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00239439
81* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98904343
82E2F1_21310950_ChIP-Seq_MCF-7_Human0.98449504
83RNF2_27304074_Chip-Seq_NSC_Mouse0.98035193
84* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97429410
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95751554
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95533550
87CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94082038
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93592306
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92561586
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.92561586
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.92406383
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92126700
93SOX2_19829295_ChIP-Seq_ESCs_Human0.91969700
94NANOG_19829295_ChIP-Seq_ESCs_Human0.91969700
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91890261
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91792736
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91184715
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.89677846
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88686052
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87726357
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86529591
102HTT_18923047_ChIP-ChIP_STHdh_Human0.86496363
103ELF5_23300383_ChIP-Seq_T47D_Human0.85655901
104SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84257103
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84099457
106TAL1_26923725_Chip-Seq_HPCs_Mouse0.84032479
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.81919541
108STAT3_18555785_Chip-Seq_ESCs_Mouse0.81657945
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.81573949
110EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81429932
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81257768
112AR_20517297_ChIP-Seq_VCAP_Human0.81187210
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.80180023
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80010391
115SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79624101
116EZH2_27294783_Chip-Seq_NPCs_Mouse0.79531449
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78878860
118P53_22387025_ChIP-Seq_ESCs_Mouse0.78724558
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.78603473
120RUNX1_27457419_Chip-Seq_LIVER_Mouse0.78154084
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78059194
122P300_18555785_Chip-Seq_ESCs_Mouse0.77970688
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76873771
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75509385
125NMYC_18555785_Chip-Seq_ESCs_Mouse0.75478911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.21602527
2MP0001529_abnormal_vocalization4.06120063
3MP0003880_abnormal_central_pattern3.78614293
4MP0003136_yellow_coat_color3.61328601
5MP0001905_abnormal_dopamine_level3.36528933
6MP0001188_hyperpigmentation2.30267325
7MP0000372_irregular_coat_pigmentation2.24202912
8MP0002163_abnormal_gland_morphology2.21167778
9MP0000920_abnormal_myelination2.20161174
10MP0005409_darkened_coat_color2.15876545
11MP0006276_abnormal_autonomic_nervous2.09289050
12MP0005171_absent_coat_pigmentation2.02659122
13MP0004142_abnormal_muscle_tone1.99972130
14MP0001986_abnormal_taste_sensitivity1.92321156
15MP0003011_delayed_dark_adaptation1.92055923
16MP0008057_abnormal_DNA_replication1.91613066
17MP0005379_endocrine/exocrine_gland_phen1.91419540
18MP0003718_maternal_effect1.91391474
19MP0004381_abnormal_hair_follicle1.89621008
20MP0003195_calcinosis1.83218536
21MP0006292_abnormal_olfactory_placode1.79592731
22MP0005423_abnormal_somatic_nervous1.78019600
23MP0002837_dystrophic_cardiac_calcinosis1.77058782
24MP0004742_abnormal_vestibular_system1.76568672
25MP0003077_abnormal_cell_cycle1.70641073
26MP0002638_abnormal_pupillary_reflex1.67543102
27MP0002272_abnormal_nervous_system1.59604899
28MP0008875_abnormal_xenobiotic_pharmacok1.52844149
29MP0001485_abnormal_pinna_reflex1.51080013
30MP0003111_abnormal_nucleus_morphology1.50749487
31MP0002277_abnormal_respiratory_mucosa1.45575048
32MP0002102_abnormal_ear_morphology1.45031709
33MP0002938_white_spotting1.40991755
34MP0008058_abnormal_DNA_repair1.39461167
35MP0008932_abnormal_embryonic_tissue1.38805821
36MP0001984_abnormal_olfaction1.38587939
37MP0003315_abnormal_perineum_morphology1.38256249
38MP0003186_abnormal_redox_activity1.37572689
39MP0003786_premature_aging1.35346251
40MP0001293_anophthalmia1.34887351
41MP0000566_synostosis1.34679637
42MP0002734_abnormal_mechanical_nocicepti1.33068247
43MP0005408_hypopigmentation1.32079840
44MP0008877_abnormal_DNA_methylation1.31331501
45MP0005646_abnormal_pituitary_gland1.31248351
46MP0003693_abnormal_embryo_hatching1.31199923
47MP0006036_abnormal_mitochondrial_physio1.29783713
48MP0002090_abnormal_vision1.29218167
49MP0001440_abnormal_grooming_behavior1.27540550
50MP0003938_abnormal_ear_development1.26628420
51MP0008007_abnormal_cellular_replicative1.25322597
52MP0001764_abnormal_homeostasis1.25002827
53MP0001486_abnormal_startle_reflex1.24587393
54MP0002736_abnormal_nociception_after1.24428002
55MP0004957_abnormal_blastocyst_morpholog1.24360920
56MP0008872_abnormal_physiological_respon1.23530709
57MP0000778_abnormal_nervous_system1.23108283
58MP0006035_abnormal_mitochondrial_morpho1.22562081
59MP0006072_abnormal_retinal_apoptosis1.21849860
60MP0002148_abnormal_hypersensitivity_rea1.20698540
61MP0003941_abnormal_skin_development1.19654794
62MP0008260_abnormal_autophagy1.19211337
63MP0000015_abnormal_ear_pigmentation1.18604517
64MP0001968_abnormal_touch/_nociception1.17825012
65MP0009697_abnormal_copulation1.15450845
66MP0004270_analgesia1.14556648
67MP0002210_abnormal_sex_determination1.13157049
68MP0001727_abnormal_embryo_implantation1.11891072
69MP0002064_seizures1.11260736
70MP0003950_abnormal_plasma_membrane1.10109705
71MP0009745_abnormal_behavioral_response1.09776346
72MP0004215_abnormal_myocardial_fiber1.09461245
73MP0002735_abnormal_chemical_nociception1.06006429
74MP0005332_abnormal_amino_acid1.04628848
75MP0008789_abnormal_olfactory_epithelium1.03366801
76MP0001970_abnormal_pain_threshold1.03009130
77MP0003121_genomic_imprinting1.02905651
78MP0000026_abnormal_inner_ear1.02584303
79MP0002282_abnormal_trachea_morphology1.02358723
80MP0001963_abnormal_hearing_physiology1.01860215
81MP0002751_abnormal_autonomic_nervous1.01696219
82MP0002572_abnormal_emotion/affect_behav1.01627808
83MP0001929_abnormal_gametogenesis1.01105987
84MP0010386_abnormal_urinary_bladder1.00697722
85MP0009046_muscle_twitch0.97849329
86MP0005551_abnormal_eye_electrophysiolog0.97603020
87MP0001542_abnormal_bone_strength0.97505272
88MP0000653_abnormal_sex_gland0.97334170
89MP0000358_abnormal_cell_content/0.97308980
90MP0003724_increased_susceptibility_to0.97252575
91MP0004147_increased_porphyrin_level0.96206658
92MP0005410_abnormal_fertilization0.95504487
93MP0002132_abnormal_respiratory_system0.94910958
94MP0002234_abnormal_pharynx_morphology0.94883986
95MP0001145_abnormal_male_reproductive0.94489838
96MP0008995_early_reproductive_senescence0.94424363
97MP0004145_abnormal_muscle_electrophysio0.94352304
98MP0002752_abnormal_somatic_nervous0.94345564
99MP0002822_catalepsy0.92373690
100MP0003806_abnormal_nucleotide_metabolis0.92035696
101MP0000647_abnormal_sebaceous_gland0.91344123
102MP0002909_abnormal_adrenal_gland0.89845458
103MP0004133_heterotaxia0.89496733
104MP0002095_abnormal_skin_pigmentation0.89062499
105MP0005389_reproductive_system_phenotype0.88388979
106MP0005253_abnormal_eye_physiology0.87867080
107MP0002184_abnormal_innervation0.87626601
108MP0002876_abnormal_thyroid_physiology0.87305913
109MP0003137_abnormal_impulse_conducting0.86806859
110MP0002160_abnormal_reproductive_system0.86083652
111MP0001661_extended_life_span0.85364276
112MP0001919_abnormal_reproductive_system0.84812702
113MP0000631_abnormal_neuroendocrine_gland0.82830952
114MP0002067_abnormal_sensory_capabilities0.81802933
115MP0003567_abnormal_fetal_cardiomyocyte0.80677527
116MP0005645_abnormal_hypothalamus_physiol0.80122804
117MP0004134_abnormal_chest_morphology0.80040145
118MP0002229_neurodegeneration0.79217693
119MP0005386_behavior/neurological_phenoty0.78229533
120MP0004924_abnormal_behavior0.78229533
121MP0003890_abnormal_embryonic-extraembry0.77982761
122MP0005075_abnormal_melanosome_morpholog0.77547361
123MP0005391_vision/eye_phenotype0.76129825
124MP0003698_abnormal_male_reproductive0.75617428
125MP0001286_abnormal_eye_development0.73666344
126MP0003634_abnormal_glial_cell0.73173468
127MP0005394_taste/olfaction_phenotype0.71820569
128MP0005499_abnormal_olfactory_system0.71820569
129MP0010094_abnormal_chromosome_stability0.71212867
130MP0002733_abnormal_thermal_nociception0.71059244
131MP0003787_abnormal_imprinting0.70368446
132MP0000427_abnormal_hair_cycle0.70097383
133MP0005636_abnormal_mineral_homeostasis0.69794206
134MP0002557_abnormal_social/conspecific_i0.69206015
135MP0001346_abnormal_lacrimal_gland0.68314315
136MP0003937_abnormal_limbs/digits/tail_de0.67717727
137MP0005195_abnormal_posterior_eye0.66308472
138MP0005084_abnormal_gallbladder_morpholo0.65481332
139MP0009785_altered_susceptibility_to0.65038018
140MP0005451_abnormal_body_composition0.64443813
141MP0005671_abnormal_response_to0.63988359

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.06935952
2Abnormal mitochondria in muscle tissue (HP:0008316)5.26069056
3Mitochondrial inheritance (HP:0001427)5.20501822
4Progressive macrocephaly (HP:0004481)5.09370947
5Acute encephalopathy (HP:0006846)4.74231941
6Increased hepatocellular lipid droplets (HP:0006565)4.70638915
7Increased CSF lactate (HP:0002490)4.33377747
8Renal Fanconi syndrome (HP:0001994)4.25950336
9Hepatocellular necrosis (HP:0001404)4.10000087
10Lipid accumulation in hepatocytes (HP:0006561)4.04374378
113-Methylglutaconic aciduria (HP:0003535)4.02380534
12Parakeratosis (HP:0001036)3.98946135
13Abnormality of cells of the erythroid lineage (HP:0012130)3.80762421
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.76865684
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.76789585
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.70160244
17Increased serum pyruvate (HP:0003542)3.47567777
18Abnormality of glycolysis (HP:0004366)3.47567777
19Hepatic necrosis (HP:0002605)3.36662851
20Leukodystrophy (HP:0002415)3.34796622
21Abnormal number of erythroid precursors (HP:0012131)3.31098932
22Optic disc pallor (HP:0000543)3.17929845
23Exertional dyspnea (HP:0002875)3.12239214
24Exercise intolerance (HP:0003546)3.10139605
25Cerebral edema (HP:0002181)3.05132153
26Increased intramyocellular lipid droplets (HP:0012240)3.04923659
27Reticulocytopenia (HP:0001896)3.01414395
28Respiratory failure (HP:0002878)2.97547096
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91927647
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91927647
31Macrocytic anemia (HP:0001972)2.86946980
32Abnormality of renal resorption (HP:0011038)2.85654904
33Increased serum lactate (HP:0002151)2.77995850
34Lactic acidosis (HP:0003128)2.67840309
35Respiratory difficulties (HP:0002880)2.65725940
36Sensory axonal neuropathy (HP:0003390)2.63067306
37Abnormality of the labia minora (HP:0012880)2.59577798
38Congenital ichthyosiform erythroderma (HP:0007431)2.57595063
39Cerebral hypomyelination (HP:0006808)2.56642553
40Hypothermia (HP:0002045)2.40453535
41Medial flaring of the eyebrow (HP:0010747)2.39458048
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38701897
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.38701897
44Pallor (HP:0000980)2.37731561
45Abnormality of the axillary hair (HP:0100134)2.36768601
46Abnormality of secondary sexual hair (HP:0009888)2.36768601
47Abnormality of midbrain morphology (HP:0002418)2.36374497
48Molar tooth sign on MRI (HP:0002419)2.36374497
49Abnormality of the anterior horn cell (HP:0006802)2.34637715
50Degeneration of anterior horn cells (HP:0002398)2.34637715
51Lethargy (HP:0001254)2.34435978
52Increased muscle lipid content (HP:0009058)2.32309724
53Oral leukoplakia (HP:0002745)2.31373831
54Abnormality of methionine metabolism (HP:0010901)2.30114680
55Type I transferrin isoform profile (HP:0003642)2.28544899
56Aplastic anemia (HP:0001915)2.27174945
57Methylmalonic aciduria (HP:0012120)2.26843203
58Colon cancer (HP:0003003)2.16354187
59Abnormal respiratory epithelium morphology (HP:0012253)2.14696947
60Abnormal respiratory motile cilium morphology (HP:0005938)2.14696947
61X-linked dominant inheritance (HP:0001423)2.14319505
62Abnormality of placental membranes (HP:0011409)2.08976887
63Amniotic constriction ring (HP:0009775)2.08976887
64Pancreatic fibrosis (HP:0100732)2.08596483
65Reduced antithrombin III activity (HP:0001976)2.07163940
66Microvesicular hepatic steatosis (HP:0001414)2.07027081
67Adrenal hypoplasia (HP:0000835)2.06702481
68Hypoglycemic coma (HP:0001325)2.06290104
69Abnormal ciliary motility (HP:0012262)2.05966375
70Aplasia/hypoplasia of the uterus (HP:0008684)2.04174543
71Hypoplastic pelvis (HP:0008839)2.03725580
72Generalized aminoaciduria (HP:0002909)2.03117019
73Congenital primary aphakia (HP:0007707)2.01333778
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01223284
75Gait imbalance (HP:0002141)1.99978969
76Meckel diverticulum (HP:0002245)1.97717256
77Abnormality of alanine metabolism (HP:0010916)1.96480421
78Hyperalaninemia (HP:0003348)1.96480421
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96480421
80Nephronophthisis (HP:0000090)1.96180055
81Stenosis of the external auditory canal (HP:0000402)1.95373192
82Abnormality of serum amino acid levels (HP:0003112)1.94409664
83Nephrogenic diabetes insipidus (HP:0009806)1.94262019
84Abnormality of the ileum (HP:0001549)1.93929373
85Pancreatic cysts (HP:0001737)1.91193917
86Irregular epiphyses (HP:0010582)1.90752304
87Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89327318
88Absent/shortened dynein arms (HP:0200106)1.87808059
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.87808059
90Hyperglycinemia (HP:0002154)1.87478574
91Megaloblastic anemia (HP:0001889)1.86531541
92Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85056875
93True hermaphroditism (HP:0010459)1.84643695
94Breast hypoplasia (HP:0003187)1.82372826
95Vaginal atresia (HP:0000148)1.82186270
96Genital tract atresia (HP:0001827)1.82039436
97Retinal dysplasia (HP:0007973)1.80724121
98Congenital, generalized hypertrichosis (HP:0004540)1.80088401
99Duplicated collecting system (HP:0000081)1.79487995
100Pheochromocytoma (HP:0002666)1.77411095
101Abnormality of urine glucose concentration (HP:0011016)1.77227413
102Glycosuria (HP:0003076)1.77227413
103Pancytopenia (HP:0001876)1.76942114
104Hyperphosphaturia (HP:0003109)1.76817529
105Birth length less than 3rd percentile (HP:0003561)1.76802803
106Abnormal pupillary function (HP:0007686)1.76053442
107Abnormal lung lobation (HP:0002101)1.75788789
108Renal cortical cysts (HP:0000803)1.75341427
109Abnormality of chromosome stability (HP:0003220)1.75324741
110Short tibia (HP:0005736)1.73269563
111Small epiphyses (HP:0010585)1.72223039
112Median cleft lip (HP:0000161)1.72017658
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.71119573
114CNS demyelination (HP:0007305)1.70208639
115Abnormal respiratory motile cilium physiology (HP:0012261)1.70186397
116Sclerocornea (HP:0000647)1.69350347
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69170261
118Hyperinsulinemic hypoglycemia (HP:0000825)1.69146467
119Sparse eyelashes (HP:0000653)1.69007825
120Abnormality of vitamin B metabolism (HP:0004340)1.68493822
121Septo-optic dysplasia (HP:0100842)1.68102923
122Abnormal hair whorl (HP:0010721)1.67268756
123Rough bone trabeculation (HP:0100670)1.66766393
124Renal tubular dysfunction (HP:0000124)1.66658035
125Palpitations (HP:0001962)1.66569981
126Abnormal protein glycosylation (HP:0012346)1.66132005
127Abnormal glycosylation (HP:0012345)1.66132005
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66132005
129Abnormal protein N-linked glycosylation (HP:0012347)1.66132005
130CNS hypomyelination (HP:0003429)1.65780722
131Patchy hypopigmentation of hair (HP:0011365)1.65402878
132Asplenia (HP:0001746)1.64097128
133Neuroendocrine neoplasm (HP:0100634)1.63096337
134Methylmalonic acidemia (HP:0002912)1.58321979
135Hepatosplenomegaly (HP:0001433)1.57445197
136Abnormality of the renal collecting system (HP:0004742)1.55135975
137Aplasia/Hypoplasia involving the musculature (HP:0001460)1.53882456
138Blindness (HP:0000618)1.52852361
139Abnormal hemoglobin (HP:0011902)1.52685099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.36311958
2MST43.35022237
3VRK23.16005413
4PBK3.00424973
5STK392.90565995
6BUB12.84569102
7TNIK2.50730969
8NME22.50595942
9TRIM282.21321420
10VRK12.12669968
11OXSR12.12587534
12NEK12.10687090
13BMPR1B2.08439183
14CASK2.03074282
15BCR2.03001484
16EIF2AK32.02064221
17MAP4K21.96106599
18SRPK11.88208813
19NME11.82740895
20PNCK1.82259257
21CDC71.81101023
22ARAF1.76180188
23WEE11.71266716
24EIF2AK11.69163567
25MAPKAPK51.68903919
26MKNK11.58613508
27MUSK1.56076122
28TTK1.51787045
29CDK191.45242439
30PLK41.44493660
31BMPR21.34512421
32MAP3K121.34267201
33IRAK41.33160306
34ADRBK21.31196042
35DYRK21.29210074
36FRK1.28666724
37GRK71.25834778
38PIM21.25699749
39ACVR1B1.24738238
40WNK41.24415945
41TLK11.22859901
42CSNK1G31.17144791
43NEK61.05279403
44MAP3K41.03411190
45MKNK21.01639154
46TAF10.98034918
47PKN10.95659856
48MAP2K70.94580408
49UHMK10.94323140
50LIMK10.93313558
51EIF2AK20.90643623
52ABL20.89810259
53BRSK20.89456907
54GRK50.88902334
55BCKDK0.88474647
56MAPK130.86492594
57IRAK20.86481211
58PLK20.85774357
59RPS6KA50.84776353
60PLK30.82734615
61CAMK2B0.81081545
62CDK80.81039641
63AURKB0.80878658
64INSRR0.80443150
65BRAF0.79455550
66BRSK10.79064902
67MYLK0.79042523
68ZAK0.78529528
69CSNK1G10.78026162
70STK38L0.77800821
71YES10.77662849
72FGR0.77186246
73IRAK10.75492199
74MAPK150.73861258
75AURKA0.71214324
76TSSK60.70530355
77IRAK30.68476399
78CCNB10.67672364
79CSNK1A1L0.64331791
80TESK10.63761418
81CSNK1G20.63513446
82CAMK2D0.63045559
83FES0.62098849
84TEC0.61574344
85PRKCG0.60739251
86PAK40.59965077
87DAPK10.59845632
88PASK0.58815233
89MINK10.57838161
90ATR0.56894250
91PDK20.56838741
92CSNK2A10.56609935
93OBSCN0.56448476
94PAK30.55605860
95CAMK2A0.55077070
96TXK0.54983482
97DYRK30.54356087
98WNK30.53914309
99MARK10.53772666
100CDK30.53416351
101CSNK2A20.53159524
102GRK10.52586752
103PRKCE0.50814540
104ROCK20.49505957
105RPS6KA40.49380113
106EPHA40.49027115
107PHKG20.45879223
108PHKG10.45879223
109STK40.45015773
110CAMK2G0.44988188
111PRKCI0.44738172
112LYN0.44240930
113TESK20.44010746
114ADRBK10.43795397
115STK30.43400296
116KDR0.42655838
117AKT30.42564273
118CHEK20.42009617
119NUAK10.41799222
120PLK10.40966506
121FGFR10.40925274
122CLK10.39842768
123IKBKB0.39281423
124CSNK1A10.38220464
125ATM0.37914294
126PRKCQ0.37293362
127EPHB10.36425380
128CDK140.36193098
129PRKACA0.35854841
130RIPK40.35149364
131ERBB30.34839410
132ERBB40.34752720
133CSNK1E0.34511492
134TIE10.33547515
135PINK10.33464470
136PAK10.31523660
137SCYL20.30210440
138ILK0.29185333

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.03761948
2Ribosome_Homo sapiens_hsa030104.54472179
3Parkinsons disease_Homo sapiens_hsa050124.21395827
4Proteasome_Homo sapiens_hsa030504.20740073
5Protein export_Homo sapiens_hsa030603.70851624
6* RNA polymerase_Homo sapiens_hsa030203.39028573
7Alzheimers disease_Homo sapiens_hsa050103.21078522
8Huntingtons disease_Homo sapiens_hsa050163.09005103
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.85662748
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.57702401
11Steroid biosynthesis_Homo sapiens_hsa001001.93760336
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83249957
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78009201
14Basal transcription factors_Homo sapiens_hsa030221.77911812
15* Pyrimidine metabolism_Homo sapiens_hsa002401.76650091
16Spliceosome_Homo sapiens_hsa030401.74558826
17Fatty acid elongation_Homo sapiens_hsa000621.71466186
18Cardiac muscle contraction_Homo sapiens_hsa042601.64774341
19Homologous recombination_Homo sapiens_hsa034401.60822374
20Nucleotide excision repair_Homo sapiens_hsa034201.55395893
21Propanoate metabolism_Homo sapiens_hsa006401.50088907
22Collecting duct acid secretion_Homo sapiens_hsa049661.49800638
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43605947
24One carbon pool by folate_Homo sapiens_hsa006701.43556727
25DNA replication_Homo sapiens_hsa030301.38114943
26Ether lipid metabolism_Homo sapiens_hsa005651.38102175
27Mismatch repair_Homo sapiens_hsa034301.34933934
28* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30180482
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29368285
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.20344920
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17223777
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17186035
33Non-homologous end-joining_Homo sapiens_hsa034501.17015013
34* Purine metabolism_Homo sapiens_hsa002301.13632887
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10300026
36Pyruvate metabolism_Homo sapiens_hsa006201.08546378
37RNA degradation_Homo sapiens_hsa030181.08304145
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07638416
39Rheumatoid arthritis_Homo sapiens_hsa053231.06092108
40Butanoate metabolism_Homo sapiens_hsa006501.02530937
41Sphingolipid metabolism_Homo sapiens_hsa006001.00041320
42Sulfur metabolism_Homo sapiens_hsa009200.98251018
43Vibrio cholerae infection_Homo sapiens_hsa051100.96310207
44RNA transport_Homo sapiens_hsa030130.93969461
45Fanconi anemia pathway_Homo sapiens_hsa034600.92482371
46Phototransduction_Homo sapiens_hsa047440.89413828
47Arachidonic acid metabolism_Homo sapiens_hsa005900.89274871
48Vitamin B6 metabolism_Homo sapiens_hsa007500.83548609
49Base excision repair_Homo sapiens_hsa034100.81425993
50Serotonergic synapse_Homo sapiens_hsa047260.79644865
51Graft-versus-host disease_Homo sapiens_hsa053320.77300699
52Autoimmune thyroid disease_Homo sapiens_hsa053200.75264170
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74190033
54* Metabolic pathways_Homo sapiens_hsa011000.73218295
55Linoleic acid metabolism_Homo sapiens_hsa005910.73072447
56Regulation of autophagy_Homo sapiens_hsa041400.73037333
57Glutathione metabolism_Homo sapiens_hsa004800.72293015
58Allograft rejection_Homo sapiens_hsa053300.70491028
59Tryptophan metabolism_Homo sapiens_hsa003800.69398531
60Selenocompound metabolism_Homo sapiens_hsa004500.65711535
61Caffeine metabolism_Homo sapiens_hsa002320.65504812
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64219039
63Folate biosynthesis_Homo sapiens_hsa007900.61083309
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60917291
65Asthma_Homo sapiens_hsa053100.60096724
66Phagosome_Homo sapiens_hsa041450.56650169
67Chemical carcinogenesis_Homo sapiens_hsa052040.54262435
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53960478
69Sulfur relay system_Homo sapiens_hsa041220.53381763
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52833129
71Nicotine addiction_Homo sapiens_hsa050330.52499155
72* Epstein-Barr virus infection_Homo sapiens_hsa051690.51836319
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51458107
74Carbon metabolism_Homo sapiens_hsa012000.51361946
75Histidine metabolism_Homo sapiens_hsa003400.51108263
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.50343418
77beta-Alanine metabolism_Homo sapiens_hsa004100.50328407
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50162660
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49511819
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47818836
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47338677
82Nitrogen metabolism_Homo sapiens_hsa009100.47263412
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46286570
84Tyrosine metabolism_Homo sapiens_hsa003500.45146545
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42503882
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42136396
87Circadian rhythm_Homo sapiens_hsa047100.41687509
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41463675
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41100073
90Retinol metabolism_Homo sapiens_hsa008300.40853972
91Systemic lupus erythematosus_Homo sapiens_hsa053220.40820804
92Cell cycle_Homo sapiens_hsa041100.39788119
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36777659
94Arginine and proline metabolism_Homo sapiens_hsa003300.35648335
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.35314653
96Biosynthesis of amino acids_Homo sapiens_hsa012300.35261482
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34674472
98Fatty acid degradation_Homo sapiens_hsa000710.34558989
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34035914
100Fatty acid metabolism_Homo sapiens_hsa012120.33647103
101N-Glycan biosynthesis_Homo sapiens_hsa005100.33214260
102Alcoholism_Homo sapiens_hsa050340.32900527
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31284878
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31267351
105Phenylalanine metabolism_Homo sapiens_hsa003600.28487278
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28182342
107Type I diabetes mellitus_Homo sapiens_hsa049400.28118041
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.27650454
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27341599
110mRNA surveillance pathway_Homo sapiens_hsa030150.26518437
111Hematopoietic cell lineage_Homo sapiens_hsa046400.24407585
112Olfactory transduction_Homo sapiens_hsa047400.23821175
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21197301
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20668091
115Axon guidance_Homo sapiens_hsa043600.20427835
116Long-term depression_Homo sapiens_hsa047300.19328407
117Vitamin digestion and absorption_Homo sapiens_hsa049770.18525005
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.18356794
119GABAergic synapse_Homo sapiens_hsa047270.17361095
120Taste transduction_Homo sapiens_hsa047420.17095729
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16052492
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15927323
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13963423
124Glutamatergic synapse_Homo sapiens_hsa047240.13008349
125Malaria_Homo sapiens_hsa051440.10919891
126Primary immunodeficiency_Homo sapiens_hsa053400.10909436
127Oocyte meiosis_Homo sapiens_hsa041140.10097696
128Morphine addiction_Homo sapiens_hsa050320.08142270
129p53 signaling pathway_Homo sapiens_hsa041150.06599612
130African trypanosomiasis_Homo sapiens_hsa051430.06559295
131Peroxisome_Homo sapiens_hsa041460.06446853
132Other glycan degradation_Homo sapiens_hsa005110.05872493
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05858042
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.05748869
135Synaptic vesicle cycle_Homo sapiens_hsa047210.05233193
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04665678

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