POLR2M

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.06360832
2pore complex assembly (GO:0046931)4.33908036
3positive regulation of mitotic sister chromatid separation (GO:1901970)4.23130031
4positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.23130031
5positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.23130031
6paraxial mesoderm development (GO:0048339)4.11031789
7negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.07122731
8regulation of histone H3-K9 methylation (GO:0051570)4.06801761
9regulation of female gonad development (GO:2000194)3.99906803
10peptidyl-arginine omega-N-methylation (GO:0035247)3.82998062
11pre-miRNA processing (GO:0031054)3.81117126
12mitotic sister chromatid cohesion (GO:0007064)3.79766492
13regulation of DNA methylation (GO:0044030)3.67670220
14formation of translation preinitiation complex (GO:0001731)3.64727618
15regulation of translational termination (GO:0006449)3.63291139
16oocyte development (GO:0048599)3.63206179
17metaphase plate congression (GO:0051310)3.57820062
18negative regulation of RNA splicing (GO:0033119)3.54780455
19nucleus organization (GO:0006997)3.54733078
20regulation of translational fidelity (GO:0006450)3.53529291
21nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.52654894
22establishment of chromosome localization (GO:0051303)3.49851229
23positive regulation of chromosome segregation (GO:0051984)3.49190816
24IMP biosynthetic process (GO:0006188)3.45137292
25protein localization to kinetochore (GO:0034501)3.44276353
26cytoplasmic mRNA processing body assembly (GO:0033962)3.44180514
27peptidyl-lysine dimethylation (GO:0018027)3.35832784
28mitochondrial DNA replication (GO:0006264)3.33290126
29meiotic cell cycle (GO:0051321)3.31760233
30peptidyl-arginine N-methylation (GO:0035246)3.31425118
31peptidyl-arginine methylation (GO:0018216)3.31425118
32folic acid-containing compound biosynthetic process (GO:0009396)3.31409780
33DNA strand elongation involved in DNA replication (GO:0006271)3.30242282
34gene silencing by RNA (GO:0031047)3.29309259
35regulation of meiosis I (GO:0060631)3.26312662
36viral transcription (GO:0019083)3.25860564
37negative regulation of mRNA processing (GO:0050686)3.25699076
38embryonic foregut morphogenesis (GO:0048617)3.24923081
39piRNA metabolic process (GO:0034587)3.24512330
40translational termination (GO:0006415)3.22660004
41polarized epithelial cell differentiation (GO:0030859)3.21546569
42COPI coating of Golgi vesicle (GO:0048205)3.20360575
43Golgi transport vesicle coating (GO:0048200)3.20360575
44ribosomal small subunit assembly (GO:0000028)3.20216440
45spermatid nucleus differentiation (GO:0007289)3.20099482
46mitotic nuclear envelope disassembly (GO:0007077)3.18423771
47dosage compensation (GO:0007549)3.18389769
48establishment of apical/basal cell polarity (GO:0035089)3.17910085
49negative regulation of cell size (GO:0045792)3.17056971
50histone arginine methylation (GO:0034969)3.16235426
51translational elongation (GO:0006414)3.13156519
52regulation of RNA export from nucleus (GO:0046831)3.10488296
53DNA replication-dependent nucleosome assembly (GO:0006335)3.09259972
54DNA replication-dependent nucleosome organization (GO:0034723)3.09259972
55IMP metabolic process (GO:0046040)3.08937138
56membrane disassembly (GO:0030397)3.07461934
57nuclear envelope disassembly (GO:0051081)3.07461934
58DNA strand elongation (GO:0022616)3.05920104
59mitotic G1 DNA damage checkpoint (GO:0031571)3.03820606
60binding of sperm to zona pellucida (GO:0007339)2.99812920
61translational initiation (GO:0006413)2.97904872
62regulation of acrosome reaction (GO:0060046)2.97157730
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97153681
64tricarboxylic acid cycle (GO:0006099)2.96519779
65DNA replication initiation (GO:0006270)2.95407716
66attachment of spindle microtubules to kinetochore (GO:0008608)2.93268126
67nuclear pore organization (GO:0006999)2.92781757
68spliceosomal tri-snRNP complex assembly (GO:0000244)2.92436632
69regulation of posttranscriptional gene silencing (GO:0060147)2.91122550
70regulation of gene silencing by miRNA (GO:0060964)2.91122550
71regulation of gene silencing by RNA (GO:0060966)2.91122550
72regulation of steroid hormone secretion (GO:2000831)2.89789711
73nucleobase biosynthetic process (GO:0046112)2.89401433
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87709428
75negative regulation of mRNA metabolic process (GO:1903312)2.87450698
76regulation of cAMP-dependent protein kinase activity (GO:2000479)2.87288284
77positive regulation of histone H3-K4 methylation (GO:0051571)2.86954823
78DNA duplex unwinding (GO:0032508)2.85563319
79protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.84986995
80maternal placenta development (GO:0001893)2.84600473
81histone H3-K9 demethylation (GO:0033169)2.84469053
82heterochromatin organization (GO:0070828)2.82445156
83protein localization to chromosome, centromeric region (GO:0071459)2.82214215
84DNA geometric change (GO:0032392)2.81829713
85translesion synthesis (GO:0019985)2.79684712
86skeletal muscle tissue regeneration (GO:0043403)2.78901354
87sister chromatid cohesion (GO:0007062)2.78332427
88negative regulation of DNA repair (GO:0045738)2.77811302
89mitochondrial DNA metabolic process (GO:0032042)2.76362506
90labyrinthine layer development (GO:0060711)2.75653197
91establishment of monopolar cell polarity (GO:0061162)2.74856903
92establishment or maintenance of monopolar cell polarity (GO:0061339)2.74856903
93regulation of chromosome segregation (GO:0051983)2.74297299
94maturation of SSU-rRNA (GO:0030490)2.74241551
95postreplication repair (GO:0006301)2.69397500
96nodal signaling pathway (GO:0038092)2.69156299
97regulation of spindle organization (GO:0090224)2.69029084
98planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65418900
99COPII vesicle coating (GO:0048208)2.64931515
100regulation of mitotic sister chromatid segregation (GO:0033047)2.63992666
101regulation of sister chromatid segregation (GO:0033045)2.63992666
102regulation of mitotic sister chromatid separation (GO:0010965)2.63992666
103hippo signaling (GO:0035329)2.63295161
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.62744268
105protein localization to chromosome (GO:0034502)2.61978796
106definitive hemopoiesis (GO:0060216)2.61148905
107nuclear pore complex assembly (GO:0051292)2.60352123
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60264698
109regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60264698
110glucocorticoid receptor signaling pathway (GO:0042921)2.60182500
111telomere maintenance via semi-conservative replication (GO:0032201)2.59449237
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58863542
113mitotic metaphase plate congression (GO:0007080)2.57430842
114negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.56929726
115positive regulation of SMAD protein import into nucleus (GO:0060391)2.56903933
116ribosome assembly (GO:0042255)2.56690951
117regulation of Golgi to plasma membrane protein transport (GO:0042996)2.56630791
118histone H2B ubiquitination (GO:0033523)2.56595895
119regulation of protein heterodimerization activity (GO:0043497)2.56562834
120lung-associated mesenchyme development (GO:0060484)2.55436998
121mitotic G2/M transition checkpoint (GO:0044818)2.55297851
122positive regulation of cell size (GO:0045793)2.55174202
123cellular protein complex disassembly (GO:0043624)2.55133564
124protein complex disassembly (GO:0043241)2.54431820
125single strand break repair (GO:0000012)2.53337352
126regulation of centriole replication (GO:0046599)2.53059593
127purine nucleobase biosynthetic process (GO:0009113)2.52682489
128localization within membrane (GO:0051668)2.52608664
129protein complex localization (GO:0031503)2.51970262
130oxidative phosphorylation (GO:0006119)2.50759799
131SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.50618041
132sister chromatid segregation (GO:0000819)2.50606078
133regulation of sister chromatid cohesion (GO:0007063)2.50530724
134mitotic chromosome condensation (GO:0007076)2.50040010
135regulation of hippo signaling (GO:0035330)2.48954231
136RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.48839941
137mRNA splicing, via spliceosome (GO:0000398)2.48839941
138nuclear envelope organization (GO:0006998)2.48665110
139viral life cycle (GO:0019058)2.48538239
140genitalia morphogenesis (GO:0035112)2.48002109
141negative regulation of histone methylation (GO:0031061)2.47372248
142interkinetic nuclear migration (GO:0022027)2.47317489
143DNA methylation involved in gamete generation (GO:0043046)2.46906850
144regulation of nucleobase-containing compound transport (GO:0032239)2.46401913
145mitotic spindle assembly checkpoint (GO:0007094)2.46299170
146female gamete generation (GO:0007292)2.44855668
147RNA splicing, via transesterification reactions (GO:0000375)2.44477109
148regulation of SMAD protein import into nucleus (GO:0060390)2.43967453
149spindle checkpoint (GO:0031577)2.43548011
150negative regulation of chromosome segregation (GO:0051985)2.43292989
151chromosome condensation (GO:0030261)2.42343767
152G1 DNA damage checkpoint (GO:0044783)2.42245489
153regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.41345194
154protein targeting to ER (GO:0045047)2.41232757
155negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.40939537
156negative regulation of sister chromatid segregation (GO:0033046)2.40939537
157negative regulation of mitotic sister chromatid separation (GO:2000816)2.40939537
158negative regulation of mitotic sister chromatid segregation (GO:0033048)2.40939537
159spindle assembly checkpoint (GO:0071173)2.40924315
160macromolecular complex disassembly (GO:0032984)2.40554643
161vesicle transport along microtubule (GO:0047496)2.39927733
162muscle filament sliding (GO:0030049)2.39687765
163actin-myosin filament sliding (GO:0033275)2.39687765
164regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.39362844
165positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.38707553
166regulation of NFAT protein import into nucleus (GO:0051532)2.38129248
167regulation of transforming growth factor beta2 production (GO:0032909)2.37666618
168positive regulation of histone methylation (GO:0031062)2.36440758
169phosphatidylinositol dephosphorylation (GO:0046856)2.35912324
170CENP-A containing nucleosome assembly (GO:0034080)2.35789352
171centrosome duplication (GO:0051298)2.32233310
172negative regulation of meiosis (GO:0045835)2.31712838
173mitotic spindle checkpoint (GO:0071174)2.30810123
174N-terminal protein amino acid acetylation (GO:0006474)2.30187372
175Golgi to endosome transport (GO:0006895)2.29103887
176cellular protein complex localization (GO:0034629)2.28561062
177negative regulation of heart growth (GO:0061117)2.27687490
178negative regulation of cardiac muscle tissue growth (GO:0055022)2.27687490
179positive regulation of reproductive process (GO:2000243)2.23511517
180negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.21744615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.44514026
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.26342762
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.99524363
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.84432346
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.21285675
6EZH2_22144423_ChIP-Seq_EOC_Human3.00066012
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97806199
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.80716905
9MYC_22102868_ChIP-Seq_BL_Human2.71141893
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61440876
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59725444
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48287885
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47464742
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39857550
15XRN2_22483619_ChIP-Seq_HELA_Human2.33329795
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32866610
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31199986
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.25627256
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.25313439
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.22618537
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15073108
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09197254
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08186299
24FUS_26573619_Chip-Seq_HEK293_Human2.07999675
25ZFX_18555785_ChIP-Seq_MESCs_Mouse2.02759393
26AR_21909140_ChIP-Seq_LNCAP_Human2.01112267
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99079931
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96688935
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95341717
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90039263
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.86498368
32ZNF263_19887448_ChIP-Seq_K562_Human1.85538524
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85211401
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81247387
35CIITA_25753668_ChIP-Seq_RAJI_Human1.79887835
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75138356
37EWS_26573619_Chip-Seq_HEK293_Human1.71710620
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70955797
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67616131
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66905899
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65554364
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63985493
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.61164100
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60460099
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60188037
46TAF15_26573619_Chip-Seq_HEK293_Human1.58322627
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58322412
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58108657
49TTF2_22483619_ChIP-Seq_HELA_Human1.56179869
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54783126
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52599840
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52156955
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51776046
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51166965
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50639961
56GABP_19822575_ChIP-Seq_HepG2_Human1.50351556
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49698599
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.49614445
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49409456
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48189336
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48177928
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47924059
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47204909
64ELK1_19687146_ChIP-ChIP_HELA_Human1.46923941
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46822501
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45992476
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45369575
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45193403
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44629473
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44490424
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43906293
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43740928
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43706653
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43595631
75VDR_21846776_ChIP-Seq_THP-1_Human1.43096207
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42512536
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.42393551
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42252449
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42152181
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41129980
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.41064921
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40380040
83BRD4_25478319_ChIP-Seq_HGPS_Human1.39245535
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39182018
85GBX2_23144817_ChIP-Seq_PC3_Human1.38848441
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.38029190
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36452223
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36074788
89CLOCK_20551151_ChIP-Seq_293T_Human1.35171619
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34317223
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34306258
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.33663463
93IGF1R_20145208_ChIP-Seq_DFB_Human1.33473825
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32777510
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.32646257
96SMAD4_21799915_ChIP-Seq_A2780_Human1.31348883
97GABP_17652178_ChIP-ChIP_JURKAT_Human1.31132939
98DCP1A_22483619_ChIP-Seq_HELA_Human1.30861373
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30380528
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29651577
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27446530
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27312450
103KDM5A_27292631_Chip-Seq_BREAST_Human1.25772802
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24660856
105P300_19829295_ChIP-Seq_ESCs_Human1.23701091
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23484469
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.23391701
108KDM2B_26808549_Chip-Seq_DND41_Human1.22994726
109ATF3_27146783_Chip-Seq_COLON_Human1.21940432
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21532635
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21529695
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21287955
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20987522
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19207622
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18947629
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18356541
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18017695
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17158004
119RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16599847
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.16581368
121FOXP3_21729870_ChIP-Seq_TREG_Human1.16565896
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16185674
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16004357
124OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15840851
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14476268
126VDR_23849224_ChIP-Seq_CD4+_Human1.13069684
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13049891
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13049891
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12888721
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12738856
131CHD1_26751641_Chip-Seq_LNCaP_Human1.11338494
132TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11150195
133KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10974055
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10906948
135TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10676714
136TP63_17297297_ChIP-ChIP_HaCaT_Human1.08408525
137GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08356647
138SALL4_22934838_ChIP-ChIP_CD34+_Human1.07981445
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07970096
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07625077
141HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07302539
142FLI1_27457419_Chip-Seq_LIVER_Mouse1.06508134
143TCF7_22412390_ChIP-Seq_EML_Mouse1.05910272
144PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03326456
145NANOG_18555785_Chip-Seq_ESCs_Mouse1.03197894
146SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02651708
147LXR_22292898_ChIP-Seq_THP-1_Human1.02647563
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02416913
149TP53_18474530_ChIP-ChIP_U2OS_Human1.02379461
150ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02061676
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02037818
152TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00304293
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99781010
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99760742
155DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99240197
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97946249
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97765114
158KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97510190
159STAT3_23295773_ChIP-Seq_U87_Human0.97499815
160RACK7_27058665_Chip-Seq_MCF-7_Human0.97000463
161FOXP1_21924763_ChIP-Seq_HESCs_Human0.96947269
162SOX17_20123909_ChIP-Seq_XEN_Mouse0.96842562
163REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96171410
164ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95137797
165FOXO3_23340844_ChIP-Seq_DLD1_Human0.94646088
166TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94425910
167E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93800871
168CBP_20019798_ChIP-Seq_JUKART_Human0.93696443
169IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93696443
170PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93663832
171TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93624555
172TFEB_21752829_ChIP-Seq_HELA_Human0.93020900
173YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92377284
174NOTCH1_21737748_ChIP-Seq_TLL_Human0.92313562
175E2F1_18555785_Chip-Seq_ESCs_Mouse0.92041870
176CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91746675
177ESR1_20079471_ChIP-ChIP_T-47D_Human0.91475257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.92934751
2MP0010030_abnormal_orbit_morphology3.47299583
3MP0003123_paternal_imprinting3.40285642
4MP0003718_maternal_effect3.29493544
5MP0003283_abnormal_digestive_organ3.05475587
6MP0002009_preneoplasia2.91940514
7MP0003705_abnormal_hypodermis_morpholog2.89154668
8MP0000537_abnormal_urethra_morphology2.73933887
9MP0004233_abnormal_muscle_weight2.70857324
10MP0003122_maternal_imprinting2.66845852
11MP0004957_abnormal_blastocyst_morpholog2.63683204
12MP0009053_abnormal_anal_canal2.58322696
13MP0003693_abnormal_embryo_hatching2.49433044
14MP0010352_gastrointestinal_tract_polyps2.35714583
15MP0003950_abnormal_plasma_membrane2.29840129
16MP0004084_abnormal_cardiac_muscle2.22902575
17MP0003111_abnormal_nucleus_morphology2.18387290
18MP0003077_abnormal_cell_cycle2.11037275
19MP0003121_genomic_imprinting2.03298605
20MP0003567_abnormal_fetal_cardiomyocyte2.02022336
21MP0001730_embryonic_growth_arrest1.97950053
22MP0008877_abnormal_DNA_methylation1.97385452
23MP0010094_abnormal_chromosome_stability1.90434833
24MP0005076_abnormal_cell_differentiation1.85019568
25MP0000751_myopathy1.84605028
26MP0002877_abnormal_melanocyte_morpholog1.84183355
27MP0009697_abnormal_copulation1.83817547
28MP0002234_abnormal_pharynx_morphology1.82563494
29MP0008789_abnormal_olfactory_epithelium1.76904168
30MP0008058_abnormal_DNA_repair1.76596303
31MP0002084_abnormal_developmental_patter1.75844378
32MP0004197_abnormal_fetal_growth/weight/1.74588167
33MP0003119_abnormal_digestive_system1.72897658
34MP0008438_abnormal_cutaneous_collagen1.70400591
35MP0001697_abnormal_embryo_size1.67911943
36MP0000350_abnormal_cell_proliferation1.64629574
37MP0002085_abnormal_embryonic_tissue1.61854559
38MP0000750_abnormal_muscle_regeneration1.59100741
39MP0005380_embryogenesis_phenotype1.57905139
40MP0001672_abnormal_embryogenesis/_devel1.57905139
41MP0005275_abnormal_skin_tensile1.56388759
42MP0006054_spinal_hemorrhage1.56276693
43MP0003984_embryonic_growth_retardation1.56105924
44MP0002088_abnormal_embryonic_growth/wei1.55185181
45MP0008007_abnormal_cellular_replicative1.50292025
46MP0003221_abnormal_cardiomyocyte_apopto1.44169828
47MP0004215_abnormal_myocardial_fiber1.43719350
48MP0002080_prenatal_lethality1.43654346
49MP0001984_abnormal_olfaction1.42216134
50MP0000428_abnormal_craniofacial_morphol1.40229754
51MP0008932_abnormal_embryonic_tissue1.39591864
52MP0002086_abnormal_extraembryonic_tissu1.39223189
53MP0010234_abnormal_vibrissa_follicle1.39141972
54MP0002653_abnormal_ependyma_morphology1.37470452
55MP0000733_abnormal_muscle_development1.36430856
56MP0005187_abnormal_penis_morphology1.36020542
57MP0000534_abnormal_ureter_morphology1.35649285
58MP0004087_abnormal_muscle_fiber1.35487248
59MP0003942_abnormal_urinary_system1.35323202
60MP0010630_abnormal_cardiac_muscle1.34123940
61MP0003115_abnormal_respiratory_system1.32990630
62MP0000013_abnormal_adipose_tissue1.31495912
63MP0003646_muscle_fatigue1.30131312
64MP0002269_muscular_atrophy1.28168210
65MP0005623_abnormal_meninges_morphology1.27406814
66MP0005499_abnormal_olfactory_system1.25694235
67MP0005394_taste/olfaction_phenotype1.25694235
68MP0005330_cardiomyopathy1.24957971
69MP0001293_anophthalmia1.24927897
70MP0002796_impaired_skin_barrier1.23649326
71MP0002932_abnormal_joint_morphology1.22875329
72MP0002089_abnormal_postnatal_growth/wei1.22474040
73MP0005620_abnormal_muscle_contractility1.19794327
74MP0010678_abnormal_skin_adnexa1.19333846
75MP0001299_abnormal_eye_distance/1.19327936
76MP0002233_abnormal_nose_morphology1.18958385
77MP0002837_dystrophic_cardiac_calcinosis1.18490783
78MP0003385_abnormal_body_wall1.17112720
79MP0009672_abnormal_birth_weight1.16624728
80MP0008961_abnormal_basal_metabolism1.16411434
81MP0004272_abnormal_basement_membrane1.16361392
82MP0009384_cardiac_valve_regurgitation1.15994458
83MP0001661_extended_life_span1.15881050
84MP0004133_heterotaxia1.14383671
85MP0000747_muscle_weakness1.14087520
86MP0001929_abnormal_gametogenesis1.13857698
87MP0004145_abnormal_muscle_electrophysio1.13429339
88MP0001849_ear_inflammation1.13222202
89MP0003566_abnormal_cell_adhesion1.12876248
90MP0002282_abnormal_trachea_morphology1.12573534
91MP0005171_absent_coat_pigmentation1.09727590
92MP0005395_other_phenotype1.09124779
93MP0002106_abnormal_muscle_physiology1.06959978
94MP0000762_abnormal_tongue_morphology1.05882825
95MP0003699_abnormal_female_reproductive1.04722510
96MP0000749_muscle_degeneration1.04703583
97MP0000759_abnormal_skeletal_muscle1.04405165
98MP0000266_abnormal_heart_morphology1.04269676
99MP0003890_abnormal_embryonic-extraembry1.01474559
100MP0004185_abnormal_adipocyte_glucose1.00595064
101MP0004036_abnormal_muscle_relaxation1.00550508
102MP0001177_atelectasis1.00369994
103MP0003935_abnormal_craniofacial_develop0.99655231
104MP0003315_abnormal_perineum_morphology0.99242650
105MP0002972_abnormal_cardiac_muscle0.99219699
106MP0005501_abnormal_skin_physiology0.99201547
107MP0001544_abnormal_cardiovascular_syste0.97875467
108MP0005385_cardiovascular_system_phenoty0.97875467
109MP0002111_abnormal_tail_morphology0.96022813
110MP0000049_abnormal_middle_ear0.95731049
111MP0003937_abnormal_limbs/digits/tail_de0.95232931
112MP0010307_abnormal_tumor_latency0.94662297
113MP0008775_abnormal_heart_ventricle0.93633267
114MP0003941_abnormal_skin_development0.93352848
115MP0004270_analgesia0.93160736
116MP0004484_altered_response_of0.92153963
117MP0009703_decreased_birth_body0.92103400
118MP0003091_abnormal_cell_migration0.91036449
119MP0002092_abnormal_eye_morphology0.90441637
120MP0002108_abnormal_muscle_morphology0.89821033
121MP0004808_abnormal_hematopoietic_stem0.89418534
122MP0005621_abnormal_cell_physiology0.88726699
123MP0001915_intracranial_hemorrhage0.87131274
124MP0005369_muscle_phenotype0.87124563
125MP0002925_abnormal_cardiovascular_devel0.86322128
126MP0002249_abnormal_larynx_morphology0.85491284
127MP0005248_abnormal_Harderian_gland0.83438470
128MP0002396_abnormal_hematopoietic_system0.82763508
129MP0010368_abnormal_lymphatic_system0.81965398
130MP0005503_abnormal_tendon_morphology0.81765329
131MP0003656_abnormal_erythrocyte_physiolo0.81712492
132MP0002210_abnormal_sex_determination0.80699071
133MP0005023_abnormal_wound_healing0.79862536
134MP0002697_abnormal_eye_size0.79683033
135MP0006138_congestive_heart_failure0.79475199
136MP0003137_abnormal_impulse_conducting0.79281377
137MP0003828_pulmonary_edema0.78743758
138MP0001348_abnormal_lacrimal_gland0.78528935
139MP0000313_abnormal_cell_death0.78400820
140MP0005384_cellular_phenotype0.78343223
141MP0000358_abnormal_cell_content/0.78195065
142MP0000490_abnormal_crypts_of0.77698830
143MP0008770_decreased_survivor_rate0.75243231
144MP0003861_abnormal_nervous_system0.74482371
145MP0004130_abnormal_muscle_cell0.73545663

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.60013089
2Renal duplication (HP:0000075)3.84347258
3Nemaline bodies (HP:0003798)3.72575052
4Muscle fiber inclusion bodies (HP:0100299)3.70859204
5Thyroid carcinoma (HP:0002890)3.70175448
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.66376237
7Ependymoma (HP:0002888)3.57262762
8Protrusio acetabuli (HP:0003179)3.44307511
9Sensory axonal neuropathy (HP:0003390)3.15679423
10Colon cancer (HP:0003003)3.08053552
11Hyperacusis (HP:0010780)3.07339635
12Angiofibromas (HP:0010615)2.76878342
13Adenoma sebaceum (HP:0009720)2.76878342
14Short 4th metacarpal (HP:0010044)2.75010991
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75010991
16Hyporeflexia of lower limbs (HP:0002600)2.74871769
17Exercise-induced myalgia (HP:0003738)2.70252578
18Selective tooth agenesis (HP:0001592)2.63391207
19Pelvic girdle muscle weakness (HP:0003749)2.59350253
20Abnormality of the 4th metacarpal (HP:0010012)2.59348144
21Astrocytoma (HP:0009592)2.59183835
22Abnormality of the astrocytes (HP:0100707)2.59183835
23Shoulder girdle muscle weakness (HP:0003547)2.56622752
24Increased nuchal translucency (HP:0010880)2.52786629
25Long nose (HP:0003189)2.49852853
26Ankle contracture (HP:0006466)2.46394447
27Termporal pattern (HP:0011008)2.46134091
28Insidious onset (HP:0003587)2.46134091
29Bundle branch block (HP:0011710)2.45305553
30Myoglobinuria (HP:0002913)2.45126736
31Exercise-induced muscle cramps (HP:0003710)2.44131147
32Tetraparesis (HP:0002273)2.41251077
33Lymphangioma (HP:0100764)2.41096377
34Elfin facies (HP:0004428)2.37101726
35Distal arthrogryposis (HP:0005684)2.36820123
36Bowel diverticulosis (HP:0005222)2.36632206
37Shallow orbits (HP:0000586)2.34989078
38Multiple enchondromatosis (HP:0005701)2.32940749
39Abnormal number of incisors (HP:0011064)2.32592595
40Abnormal auditory evoked potentials (HP:0006958)2.27735928
41Vertebral arch anomaly (HP:0008438)2.26821762
42Limb-girdle muscle atrophy (HP:0003797)2.26614847
43Cerebral aneurysm (HP:0004944)2.26463526
44Enlarged penis (HP:0000040)2.26003015
45EMG: myopathic abnormalities (HP:0003458)2.24715585
46Missing ribs (HP:0000921)2.24497240
47Difficulty climbing stairs (HP:0003551)2.23968438
48Intestinal polyp (HP:0005266)2.21276432
49Intestinal polyposis (HP:0200008)2.19692978
50Abnormality of the musculature of the pelvis (HP:0001469)2.19426226
51Abnormality of the hip-girdle musculature (HP:0001445)2.19426226
52Menstrual irregularities (HP:0000858)2.18730699
53Ankyloglossia (HP:0010296)2.17172434
54Cubitus valgus (HP:0002967)2.13068394
55Insomnia (HP:0100785)2.12813049
56Broad palm (HP:0001169)2.12430890
57Transitional cell carcinoma of the bladder (HP:0006740)2.09026945
58Abnormality of the calf musculature (HP:0001430)2.08283428
59Truncal obesity (HP:0001956)2.07708710
60Abnormality of chromosome segregation (HP:0002916)2.06876071
61Microglossia (HP:0000171)2.06249639
62Rectal prolapse (HP:0002035)2.05292968
63Leiomyosarcoma (HP:0100243)2.04876407
64Uterine leiomyosarcoma (HP:0002891)2.04876407
65Cystic hygroma (HP:0000476)2.04062648
66Syringomyelia (HP:0003396)2.02888629
67Spinal cord lesions (HP:0100561)2.02888629
68Pointed chin (HP:0000307)2.02539429
69Fibroma (HP:0010614)2.01798755
70Renovascular hypertension (HP:0100817)2.01181564
71Gonadotropin excess (HP:0000837)2.01039787
72Glioma (HP:0009733)2.00160973
73Increased connective tissue (HP:0009025)1.98427196
74Complete atrioventricular canal defect (HP:0001674)1.98241633
75Medulloblastoma (HP:0002885)1.97837671
76Rhabdomyolysis (HP:0003201)1.97768341
77Bladder diverticulum (HP:0000015)1.97444586
78Bladder carcinoma (HP:0002862)1.97018936
79Bladder neoplasm (HP:0009725)1.97018936
80Aortic aneurysm (HP:0004942)1.96799060
81Progressive external ophthalmoplegia (HP:0000590)1.96338720
82Progressive muscle weakness (HP:0003323)1.95907506
83Overriding aorta (HP:0002623)1.95905229
84Neck muscle weakness (HP:0000467)1.94523809
85Short 5th finger (HP:0009237)1.94058868
86Muscle hypertrophy of the lower extremities (HP:0008968)1.92549202
87Ventricular tachycardia (HP:0004756)1.91766345
88Calf muscle hypertrophy (HP:0008981)1.91147727
89Sudden death (HP:0001699)1.90761738
90Fibrous tissue neoplasm (HP:0012316)1.89996485
91Increased density of long bones (HP:0006392)1.89543049
92Deviation of the hallux (HP:0010051)1.88824982
93Long clavicles (HP:0000890)1.88738372
94Biliary tract neoplasm (HP:0100574)1.88274671
95Limb-girdle muscle weakness (HP:0003325)1.87223864
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86849294
97Nephroblastoma (Wilms tumor) (HP:0002667)1.86547473
98Atrioventricular canal defect (HP:0006695)1.86037818
99Median cleft lip (HP:0000161)1.85979296
100Neoplasm of the small intestine (HP:0100833)1.85719893
101Broad thumb (HP:0011304)1.85240946
102Proximal placement of thumb (HP:0009623)1.84217959
103Deep philtrum (HP:0002002)1.84123851
104Hallux valgus (HP:0001822)1.83367374
105Aplasia involving bones of the extremities (HP:0009825)1.83332223
106Aplasia involving bones of the upper limbs (HP:0009823)1.83332223
107Aplasia of the phalanges of the hand (HP:0009802)1.83332223
108Abnormality of the calcaneus (HP:0008364)1.82813687
109Embryonal renal neoplasm (HP:0011794)1.82753814
110Hyperkalemia (HP:0002153)1.82737198
111Neoplasm of the thyroid gland (HP:0100031)1.82079122
112Short middle phalanx of the 5th finger (HP:0004220)1.81899043
113Sacral dimple (HP:0000960)1.81307675
114Abnormality of skeletal muscle fiber size (HP:0012084)1.79849031
115Flat cornea (HP:0007720)1.79769577
116Type 1 muscle fiber predominance (HP:0003803)1.78692734
117Neoplasm of the rectum (HP:0100743)1.78439862
118Proximal tubulopathy (HP:0000114)1.77307114
119Osteolytic defects of the hand bones (HP:0009699)1.76425014
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.76425014
121Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.75254428
122Neoplasm of the heart (HP:0100544)1.74239785
123Deviation of the thumb (HP:0009603)1.73759138
124Atresia of the external auditory canal (HP:0000413)1.73348158
125Palpitations (HP:0001962)1.73016084
126Exostoses (HP:0100777)1.72872195
127Trismus (HP:0000211)1.72844110
128Adducted thumb (HP:0001181)1.72796507
129Megalocornea (HP:0000485)1.71747464
130Mesomelia (HP:0003027)1.71675770
131Abnormality of oral frenula (HP:0000190)1.71116171
132Lower limb hyperreflexia (HP:0002395)1.70731526
133Abnormality of abdominal situs (HP:0011620)1.70227352
134Abdominal situs inversus (HP:0003363)1.70227352
135Acute myeloid leukemia (HP:0004808)1.69866538
136Gastrointestinal carcinoma (HP:0002672)1.69831260
137Malignant gastrointestinal tract tumors (HP:0006749)1.69831260
138Calcaneovalgus deformity (HP:0001848)1.69697183
139Abnormality of the left ventricular outflow tract (HP:0011103)1.69511204
140Subaortic stenosis (HP:0001682)1.69511204
141Broad metatarsal (HP:0001783)1.68757599
142Increased variability in muscle fiber diameter (HP:0003557)1.68600663
143Muscle fiber splitting (HP:0003555)1.68590733
144Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68552004
145Genu recurvatum (HP:0002816)1.68125774
146Neoplasm of the adrenal gland (HP:0100631)1.67117801
147Ovarian neoplasm (HP:0100615)1.66976474
148Broad phalanges of the hand (HP:0009768)1.66527609
149Broad toe (HP:0001837)1.65536005
150Neoplasm of striated muscle (HP:0009728)1.65154959
151Abnormality of the lower motor neuron (HP:0002366)1.64729160
152Ragged-red muscle fibers (HP:0003200)1.64667495
153Curly hair (HP:0002212)1.64451926
154Rimmed vacuoles (HP:0003805)1.64295751
155Abnormality of the anterior horn cell (HP:0006802)1.63783535
156Degeneration of anterior horn cells (HP:0002398)1.63783535
157Slender long bone (HP:0003100)1.63450402
158Freckling (HP:0001480)1.63009560
159Aneurysm (HP:0002617)1.62758386
160Centrally nucleated skeletal muscle fibers (HP:0003687)1.61981754
161Radial bowing (HP:0002986)1.61732226
162Hand muscle atrophy (HP:0009130)1.61616342
163Capillary hemangiomas (HP:0005306)1.61445626
164Deformed tarsal bones (HP:0008119)1.61436841
165Hypoplastic left heart (HP:0004383)1.61037806
166Neoplasm of the pancreas (HP:0002894)1.60670234
167Rhabdomyosarcoma (HP:0002859)1.59797014
168White forelock (HP:0002211)1.57758267
169Facial hemangioma (HP:0000329)1.57117878
170Heterotopia (HP:0002282)1.56731966
171Volvulus (HP:0002580)1.55875094
172Areflexia of lower limbs (HP:0002522)1.55827599
173Anterior segment dysgenesis (HP:0007700)1.55146855
174Muscle stiffness (HP:0003552)1.52369840
175Atrioventricular block (HP:0001678)1.51915868
176Hypoplastic heart (HP:0001961)1.51740320
177Relative macrocephaly (HP:0004482)1.51434129
178Neoplasm of the colon (HP:0100273)1.51031696
179Maternal diabetes (HP:0009800)1.50671402
180Short tibia (HP:0005736)1.49236239
181Abnormal biliary tract morphology (HP:0012440)1.47513766
182Lip pit (HP:0100267)1.47151563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK244.93507826
2TRIB33.80148964
3PKN23.78802364
4NEK13.62086508
5EIF2AK33.45551398
6BRD42.91072757
7BUB12.85176935
8ERBB32.63820320
9EEF2K2.63759816
10STK32.63412481
11CDC72.53434739
12MAP3K102.49988557
13WEE12.42211653
14AKT32.34118132
15SCYL22.33330794
16OBSCN2.32246222
17NEK92.30871743
18TTN2.24533502
19STK38L2.23414915
20NEK22.08686338
21TRIM282.08363153
22LATS22.04852042
23BCR2.04685373
24PBK2.00050867
25PASK1.81717292
26PAK41.81131019
27RPS6KB21.79987627
28ARAF1.78556896
29TGFBR11.76400374
30PLK41.57858214
31PIK3CG1.52162247
32PDGFRA1.51605817
33BRAF1.49650516
34KSR11.45080596
35LRRK21.44936638
36TESK21.43140561
37NEK61.41689940
38CDK121.36747153
39MOS1.34182041
40CDK91.31873139
41FLT31.31000693
42EIF2AK11.24155712
43MAP3K111.23948429
44EPHB21.23546449
45MET1.22910499
46MAP3K131.22040557
47ACVR1B1.20900175
48RIPK11.18916484
49PDK31.18778989
50PDK41.18778989
51TESK11.18152032
52PTK61.16030326
53BCKDK1.15010824
54EPHA21.14004736
55RPS6KA41.13778544
56TSSK61.13189794
57MAPKAPK31.10987642
58FGFR11.09753429
59ILK1.09723215
60MAP3K81.07792801
61ALK1.06345141
62KDR1.06141408
63MAP3K41.01123295
64CDK41.01100346
65ERN11.01051171
66LMTK21.00547980
67PLK11.00058974
68DYRK30.98898694
69MTOR0.98652621
70PAK20.96392819
71TTK0.94168792
72NME20.93593490
73KSR20.91925822
74TAOK10.90970296
75CDK70.90863449
76ICK0.89968045
77MAP2K30.87408017
78LATS10.86513565
79DDR20.86424852
80AURKB0.85458784
81LIMK10.80817409
82WNK30.78585796
83MKNK20.77643452
84AKT20.77638726
85BRSK10.76993342
86ATR0.76751704
87EIF2AK20.76718612
88CLK10.73241993
89MAPK70.68092093
90TAOK20.67367972
91AURKA0.67164415
92SGK20.66189602
93CDK60.63984857
94PLK20.63488981
95ERBB40.63474394
96ATM0.62974476
97CAMK1G0.62475340
98CDK190.62311190
99MINK10.61880604
100RPS6KB10.61868245
101CHEK10.61650292
102PHKG10.60471238
103PHKG20.60471238
104NLK0.60393911
105PAK60.59856787
106MAP3K60.59750820
107PRKD30.59349921
108NUAK10.59098680
109STK380.58765089
110BRSK20.58573480
111MELK0.55910681
112MAPK100.55797263
113CDK20.55498168
114MST40.55065398
115PLK30.54470630
116DMPK0.54280680
117TAF10.53871457
118CSNK1A1L0.53271006
119SIK10.52551938
120CAMKK10.51619720
121SGK30.51243666
122CSNK1G10.50149461
123CDK30.49151892
124PAK30.48062902
125TRPM70.47743290
126SRPK10.47581928
127PTK20.46897014
128ERBB20.45982271
129PNCK0.44943768
130PINK10.44707834
131WNK10.44251213
132STK100.44098730
133MAP3K90.44057378
134RET0.43041980
135CDK140.42939745
136MKNK10.42351612
137RAF10.42344059
138CHEK20.42111148
139TNIK0.41010993
140BMPR20.40917832
141PRPF4B0.40711624
142MAP2K70.40187453
143UHMK10.39642596
144CDK11A0.39504940
145MAP3K50.37564406
146MAP3K30.37392926
147DYRK1B0.37093215
148PAK10.37009046
149CSNK1E0.36486500
150CDK150.36213228
151CDK180.35355882
152CAMKK20.35247108
153ZAK0.34956234
154YES10.34811274
155FER0.33655747
156CDK10.32919781
157MAPK120.32838084
158CSNK1D0.28751937

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.71932754
2DNA replication_Homo sapiens_hsa030303.59157505
3Circadian rhythm_Homo sapiens_hsa047102.86116124
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.85779804
5Mismatch repair_Homo sapiens_hsa034302.74639638
6Spliceosome_Homo sapiens_hsa030402.66051784
7RNA transport_Homo sapiens_hsa030132.53004505
8Ribosome_Homo sapiens_hsa030102.30632783
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28552952
10Cell cycle_Homo sapiens_hsa041102.22140685
11Basal transcription factors_Homo sapiens_hsa030222.12161604
12Base excision repair_Homo sapiens_hsa034101.95057984
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78264289
14Inositol phosphate metabolism_Homo sapiens_hsa005621.74344827
15Biosynthesis of amino acids_Homo sapiens_hsa012301.73835456
16Basal cell carcinoma_Homo sapiens_hsa052171.73158301
17Carbon metabolism_Homo sapiens_hsa012001.71650619
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69837485
19mRNA surveillance pathway_Homo sapiens_hsa030151.66206628
20Nucleotide excision repair_Homo sapiens_hsa034201.61510175
21Hippo signaling pathway_Homo sapiens_hsa043901.53530227
22One carbon pool by folate_Homo sapiens_hsa006701.48775867
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.48301678
24Hedgehog signaling pathway_Homo sapiens_hsa043401.45251413
25Oocyte meiosis_Homo sapiens_hsa041141.44737785
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.41949916
27Non-homologous end-joining_Homo sapiens_hsa034501.41160238
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40763963
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34156451
30Prostate cancer_Homo sapiens_hsa052151.31741668
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30683623
32Thyroid cancer_Homo sapiens_hsa052161.29932925
33p53 signaling pathway_Homo sapiens_hsa041151.29575879
34Bladder cancer_Homo sapiens_hsa052191.27907915
35mTOR signaling pathway_Homo sapiens_hsa041501.26902044
36Proteasome_Homo sapiens_hsa030501.25711027
37Dorso-ventral axis formation_Homo sapiens_hsa043201.23115049
38Colorectal cancer_Homo sapiens_hsa052101.17238549
39Pyrimidine metabolism_Homo sapiens_hsa002401.12162905
40Chronic myeloid leukemia_Homo sapiens_hsa052201.09277987
41Long-term potentiation_Homo sapiens_hsa047201.07295554
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05518236
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04590484
44Dilated cardiomyopathy_Homo sapiens_hsa054141.02141050
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02086548
46Proteoglycans in cancer_Homo sapiens_hsa052051.01815369
47HTLV-I infection_Homo sapiens_hsa051661.01550657
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01330212
49RNA degradation_Homo sapiens_hsa030181.00575622
50Cardiac muscle contraction_Homo sapiens_hsa042600.99286365
51Adherens junction_Homo sapiens_hsa045200.98138556
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97756636
53Viral myocarditis_Homo sapiens_hsa054160.96624831
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96236577
55Small cell lung cancer_Homo sapiens_hsa052220.96066296
56MicroRNAs in cancer_Homo sapiens_hsa052060.95377964
57FoxO signaling pathway_Homo sapiens_hsa040680.95247280
58Notch signaling pathway_Homo sapiens_hsa043300.94911118
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.93725770
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93034105
61Long-term depression_Homo sapiens_hsa047300.91965246
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90323896
63Insulin signaling pathway_Homo sapiens_hsa049100.89536587
64Selenocompound metabolism_Homo sapiens_hsa004500.88025834
65ErbB signaling pathway_Homo sapiens_hsa040120.87982841
66Endometrial cancer_Homo sapiens_hsa052130.87387639
67AMPK signaling pathway_Homo sapiens_hsa041520.83668523
68Viral carcinogenesis_Homo sapiens_hsa052030.83599507
69HIF-1 signaling pathway_Homo sapiens_hsa040660.81710948
70Focal adhesion_Homo sapiens_hsa045100.81138552
71Glucagon signaling pathway_Homo sapiens_hsa049220.80739316
72RNA polymerase_Homo sapiens_hsa030200.80727940
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80443335
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79885961
75Homologous recombination_Homo sapiens_hsa034400.79783858
76N-Glycan biosynthesis_Homo sapiens_hsa005100.78885085
77Wnt signaling pathway_Homo sapiens_hsa043100.74689458
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74278909
79Pyruvate metabolism_Homo sapiens_hsa006200.74219524
80Tight junction_Homo sapiens_hsa045300.73629219
81ECM-receptor interaction_Homo sapiens_hsa045120.73432288
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73120415
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.70022270
84Non-small cell lung cancer_Homo sapiens_hsa052230.69654456
85Pentose phosphate pathway_Homo sapiens_hsa000300.66980265
86TGF-beta signaling pathway_Homo sapiens_hsa043500.65573368
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.65125780
88Sulfur relay system_Homo sapiens_hsa041220.64457541
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64391260
90Pathways in cancer_Homo sapiens_hsa052000.63219355
91Epstein-Barr virus infection_Homo sapiens_hsa051690.63075974
92Renin secretion_Homo sapiens_hsa049240.62608588
93VEGF signaling pathway_Homo sapiens_hsa043700.61150794
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60265421
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60196606
96Choline metabolism in cancer_Homo sapiens_hsa052310.60007911
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59399176
98Glioma_Homo sapiens_hsa052140.59394997
99Melanogenesis_Homo sapiens_hsa049160.58065502
100Insulin resistance_Homo sapiens_hsa049310.57270102
101Oxytocin signaling pathway_Homo sapiens_hsa049210.57115991
102Platelet activation_Homo sapiens_hsa046110.56603516
103Lysine degradation_Homo sapiens_hsa003100.55662991
104Hepatitis B_Homo sapiens_hsa051610.55205280
105Galactose metabolism_Homo sapiens_hsa000520.53770778
106Parkinsons disease_Homo sapiens_hsa050120.53431989
107Fanconi anemia pathway_Homo sapiens_hsa034600.53233001
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52923695
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48897354
110Gap junction_Homo sapiens_hsa045400.46728375
111Pancreatic cancer_Homo sapiens_hsa052120.46177202
112Propanoate metabolism_Homo sapiens_hsa006400.45994344
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45529950
114Arginine and proline metabolism_Homo sapiens_hsa003300.44621856
115Fructose and mannose metabolism_Homo sapiens_hsa000510.44232848
116Endocytosis_Homo sapiens_hsa041440.42785330
117Renal cell carcinoma_Homo sapiens_hsa052110.41946399
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41235078
119Estrogen signaling pathway_Homo sapiens_hsa049150.41203817
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41195074
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40857105
122Melanoma_Homo sapiens_hsa052180.40622745
123Ovarian steroidogenesis_Homo sapiens_hsa049130.40059662
124Alcoholism_Homo sapiens_hsa050340.40055608
125Acute myeloid leukemia_Homo sapiens_hsa052210.39774973
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.39212578
127Purine metabolism_Homo sapiens_hsa002300.38578284
128Steroid biosynthesis_Homo sapiens_hsa001000.38127681
129GABAergic synapse_Homo sapiens_hsa047270.38089957
130Fatty acid degradation_Homo sapiens_hsa000710.37509554
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37271978

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