POLR3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.39075394
2nuclear pore organization (GO:0006999)5.31722367
3ribosome biogenesis (GO:0042254)4.97810138
4protein localization to kinetochore (GO:0034501)4.74100472
5mitotic metaphase plate congression (GO:0007080)4.59640183
6negative regulation of histone methylation (GO:0031061)4.57194209
7histone H2A monoubiquitination (GO:0035518)4.52537070
8mitotic nuclear envelope disassembly (GO:0007077)4.50664955
9pre-miRNA processing (GO:0031054)4.41612865
10regulation of spindle organization (GO:0090224)4.35080587
11nucleobase biosynthetic process (GO:0046112)4.31735161
12ribosome assembly (GO:0042255)4.30271088
13nuclear envelope disassembly (GO:0051081)4.26753786
14membrane disassembly (GO:0030397)4.26753786
15pore complex assembly (GO:0046931)4.11203112
16maturation of 5.8S rRNA (GO:0000460)4.07651237
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.02526252
18regulation of mitotic spindle organization (GO:0060236)4.01412406
19dosage compensation (GO:0007549)3.90995365
20folic acid-containing compound biosynthetic process (GO:0009396)3.90866431
21positive regulation of chromosome segregation (GO:0051984)3.85488049
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.80143792
23metaphase plate congression (GO:0051310)3.79335679
24purine nucleobase biosynthetic process (GO:0009113)3.79309100
25mitotic chromosome condensation (GO:0007076)3.76764247
26folic acid metabolic process (GO:0046655)3.75980623
27establishment of chromosome localization (GO:0051303)3.72898594
28DNA unwinding involved in DNA replication (GO:0006268)3.72645455
29mitochondrial DNA metabolic process (GO:0032042)3.71454014
30protein localization to chromosome, centromeric region (GO:0071459)3.68119823
31regulation of histone H3-K9 methylation (GO:0051570)3.66666808
32alternative mRNA splicing, via spliceosome (GO:0000380)3.60890315
33histone H2A ubiquitination (GO:0033522)3.60131332
34histone mRNA catabolic process (GO:0071044)3.58993201
35mitochondrial DNA replication (GO:0006264)3.57958405
36IMP metabolic process (GO:0046040)3.57755393
37negative regulation of chromosome segregation (GO:0051985)3.56292272
38regulation of posttranscriptional gene silencing (GO:0060147)3.55870740
39regulation of gene silencing by miRNA (GO:0060964)3.55870740
40regulation of gene silencing by RNA (GO:0060966)3.55870740
41mitotic sister chromatid segregation (GO:0000070)3.55133560
42mitotic spindle assembly checkpoint (GO:0007094)3.53128703
43formation of translation preinitiation complex (GO:0001731)3.52496852
44DNA replication initiation (GO:0006270)3.51418280
45spindle assembly checkpoint (GO:0071173)3.50620691
46negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.49446699
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.49338825
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.49338825
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.49338825
50negative regulation of sister chromatid segregation (GO:0033046)3.49338825
51spindle checkpoint (GO:0031577)3.48807671
52regulation of translational fidelity (GO:0006450)3.48479976
53regulation of chromosome segregation (GO:0051983)3.44685605
54mitotic spindle checkpoint (GO:0071174)3.40831021
55regulation of translational termination (GO:0006449)3.39269025
56DNA replication-dependent nucleosome assembly (GO:0006335)3.39117016
57DNA replication-dependent nucleosome organization (GO:0034723)3.39117016
58rRNA catabolic process (GO:0016075)3.36260516
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.35194596
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35194596
61nuclear envelope organization (GO:0006998)3.33786885
62sister chromatid segregation (GO:0000819)3.29367910
63DNA duplex unwinding (GO:0032508)3.26813372
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25911307
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25281185
66DNA geometric change (GO:0032392)3.24705948
67regulation of RNA export from nucleus (GO:0046831)3.24342816
68regulation of sister chromatid segregation (GO:0033045)3.21656396
69regulation of mitotic sister chromatid separation (GO:0010965)3.21656396
70regulation of mitotic sister chromatid segregation (GO:0033047)3.21656396
71protein K6-linked ubiquitination (GO:0085020)3.20912958
72DNA replication checkpoint (GO:0000076)3.19635187
73negative regulation of mRNA processing (GO:0050686)3.17037763
74ribonucleoprotein complex biogenesis (GO:0022613)3.16596232
75mitotic sister chromatid cohesion (GO:0007064)3.12684753
76inner cell mass cell proliferation (GO:0001833)3.12312348
77regulation of DNA endoreduplication (GO:0032875)3.11255874
78ncRNA catabolic process (GO:0034661)3.09003579
79negative regulation of RNA splicing (GO:0033119)3.08430825
80IMP biosynthetic process (GO:0006188)3.06997302
81DNA strand elongation involved in DNA replication (GO:0006271)3.06442878
82monoubiquitinated protein deubiquitination (GO:0035520)3.04725643
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02154315
84regulation of sister chromatid cohesion (GO:0007063)3.02079268
85mRNA transport (GO:0051028)3.01511565
86protein localization to chromosome (GO:0034502)3.00872340
87spindle assembly involved in mitosis (GO:0090307)2.96090896
88attachment of spindle microtubules to kinetochore (GO:0008608)2.95214789
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94530031
90DNA strand elongation (GO:0022616)2.93957627
91heterochromatin organization (GO:0070828)2.92760882
92negative regulation of mRNA metabolic process (GO:1903312)2.91067848
93microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.90892161
94spliceosomal complex assembly (GO:0000245)2.87269834
95rRNA processing (GO:0006364)2.86610423
96negative regulation of chromosome organization (GO:2001251)2.83365219
97positive regulation of mitotic sister chromatid separation (GO:1901970)2.79958440
98positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.79958440
99positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.79958440
100rRNA metabolic process (GO:0016072)2.79946214
101mRNA export from nucleus (GO:0006406)2.79927232
102RNA export from nucleus (GO:0006405)2.79060534
103termination of RNA polymerase II transcription (GO:0006369)2.76725935
104nucleic acid transport (GO:0050657)2.76725654
105RNA transport (GO:0050658)2.76725654
106establishment of RNA localization (GO:0051236)2.76725654
107mRNA splicing, via spliceosome (GO:0000398)2.76272291
108tRNA aminoacylation for protein translation (GO:0006418)2.69477772
109amino acid activation (GO:0043038)2.68469623
110tRNA aminoacylation (GO:0043039)2.68469623
111mitochondrial RNA metabolic process (GO:0000959)2.65772285
112double-strand break repair via nonhomologous end joining (GO:0006303)2.60615830
113non-recombinational repair (GO:0000726)2.60615830
114replication fork processing (GO:0031297)2.53666347
115DNA damage response, detection of DNA damage (GO:0042769)2.53262670
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.51578662
117replicative senescence (GO:0090399)2.50591476
118chromatin remodeling at centromere (GO:0031055)2.48747284
119regulation of centrosome cycle (GO:0046605)2.48041920
120L-serine metabolic process (GO:0006563)2.47233960
121mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.46949631
122telomere maintenance via semi-conservative replication (GO:0032201)2.46128254
123chromatin assembly (GO:0031497)2.43268798
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.34086204
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.33322286
126nucleotide-excision repair, DNA gap filling (GO:0006297)2.33265558
127peptidyl-arginine omega-N-methylation (GO:0035247)2.32885421
128CENP-A containing nucleosome assembly (GO:0034080)2.30329619
129telomere maintenance via telomere lengthening (GO:0010833)2.30149032
130regulation of translational elongation (GO:0006448)2.29290838
131regulation of centriole replication (GO:0046599)2.29209171
132meiotic chromosome segregation (GO:0045132)2.28790492
133mitotic spindle organization (GO:0007052)2.28532430
134regulation of centrosome duplication (GO:0010824)2.28319381
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.26468888
136translesion synthesis (GO:0019985)2.26368468
137regulation of nuclear cell cycle DNA replication (GO:0033262)2.25942992
138regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.25104643
139chromatin assembly or disassembly (GO:0006333)2.24872478
140establishment of protein localization to mitochondrial membrane (GO:0090151)2.22739669
141spliceosomal snRNP assembly (GO:0000387)2.20041341
142histone arginine methylation (GO:0034969)2.19325004
143establishment of integrated proviral latency (GO:0075713)2.18643562
144regulation of hippo signaling (GO:0035330)2.18018873
145somatic recombination of immunoglobulin gene segments (GO:0016447)2.17958549
146ribonucleoprotein complex disassembly (GO:0032988)2.17362275
147maturation of SSU-rRNA (GO:0030490)2.17289379
148DNA replication-independent nucleosome assembly (GO:0006336)2.16140325
149DNA replication-independent nucleosome organization (GO:0034724)2.16140325
150DNA strand renaturation (GO:0000733)2.15168185
151sister chromatid cohesion (GO:0007062)2.13952187
152mitotic recombination (GO:0006312)2.13813314
153C4-dicarboxylate transport (GO:0015740)2.13638325
154transcription elongation from RNA polymerase I promoter (GO:0006362)2.12597821
155peptidyl-arginine methylation (GO:0018216)2.12526393
156peptidyl-arginine N-methylation (GO:0035246)2.12526393
157behavioral response to nicotine (GO:0035095)2.12422830
158tRNA metabolic process (GO:0006399)2.08750118
159positive regulation of cell cycle G2/M phase transition (GO:1902751)2.08051346
160positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.08051346
161NLS-bearing protein import into nucleus (GO:0006607)2.07661636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.93964687
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.68937165
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.74868542
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.54846862
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15171077
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03577604
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75346019
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73760332
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61279196
10MYC_22102868_ChIP-Seq_BL_Human2.55792957
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45903293
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.36784723
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.28851201
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23432419
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21936474
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18551989
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17439068
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.06836933
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.06086468
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04679125
21KDM5A_27292631_Chip-Seq_BREAST_Human2.00775168
22* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99927696
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99319601
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.95346267
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.92330736
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90649011
27* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90246572
28CIITA_25753668_ChIP-Seq_RAJI_Human1.88989395
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86925881
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85551185
31* XRN2_22483619_ChIP-Seq_HELA_Human1.85308784
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.85057992
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74497868
34AR_21909140_ChIP-Seq_LNCAP_Human1.73748464
35VDR_23849224_ChIP-Seq_CD4+_Human1.72364517
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71320367
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69696136
38FOXP3_21729870_ChIP-Seq_TREG_Human1.68419283
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68203589
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65974543
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63127056
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.58784643
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57865973
44ZNF274_21170338_ChIP-Seq_K562_Hela1.57381941
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56583418
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56213343
47GABP_19822575_ChIP-Seq_HepG2_Human1.55582554
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.55281828
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52519517
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52519517
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52519517
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52471633
53* MYC_18940864_ChIP-ChIP_HL60_Human1.52345759
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50154195
55ZNF263_19887448_ChIP-Seq_K562_Human1.44864230
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.44682972
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.44001740
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43915301
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43706202
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42753208
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42358826
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41036207
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40764739
64DCP1A_22483619_ChIP-Seq_HELA_Human1.39723390
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39634326
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.36713814
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35112197
68TFEB_21752829_ChIP-Seq_HELA_Human1.35093805
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33242877
70TTF2_22483619_ChIP-Seq_HELA_Human1.33220390
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32543441
72IGF1R_20145208_ChIP-Seq_DFB_Human1.31400095
73ELK1_19687146_ChIP-ChIP_HELA_Human1.30556500
74EWS_26573619_Chip-Seq_HEK293_Human1.29533911
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29234107
76FUS_26573619_Chip-Seq_HEK293_Human1.26916791
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25248871
78IRF1_19129219_ChIP-ChIP_H3396_Human1.23048073
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22554586
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20341692
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19192647
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19175213
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.18251072
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17969458
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17144284
86GBX2_23144817_ChIP-Seq_PC3_Human1.17082145
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15932544
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.13673391
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11088772
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.09088960
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08857282
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.08288122
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06853381
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05188463
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03914286
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03675280
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03521424
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03320480
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03287221
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03243851
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02071223
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01923993
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01666943
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00588208
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00507686
106TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99342121
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97917497
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97701793
109SOX9_26525672_Chip-Seq_HEART_Mouse0.95622517
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94922298
111VDR_21846776_ChIP-Seq_THP-1_Human0.94894849
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92398515
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91632661
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90917963
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.90517746
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89841850
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89476549
118YY1_21170310_ChIP-Seq_MESCs_Mouse0.87022137
119PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86278698
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85989828
121CLOCK_20551151_ChIP-Seq_293T_Human0.85532770
122TCF7_22412390_ChIP-Seq_EML_Mouse0.84781333
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83834087
124ATF3_27146783_Chip-Seq_COLON_Human0.83618638
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83531008
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83096130
127FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82741411
128SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81861440
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81631852
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80851072
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80107694
132TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79461320
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78694402
134CHD1_26751641_Chip-Seq_LNCaP_Human0.76739220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.37065674
2MP0003111_abnormal_nucleus_morphology4.27111822
3MP0003693_abnormal_embryo_hatching4.19323685
4MP0004957_abnormal_blastocyst_morpholog4.14618566
5MP0003077_abnormal_cell_cycle3.96930935
6MP0008057_abnormal_DNA_replication3.68889692
7MP0003718_maternal_effect3.05647333
8MP0001730_embryonic_growth_arrest2.99195883
9MP0008877_abnormal_DNA_methylation2.95408225
10MP0010352_gastrointestinal_tract_polyps2.89412778
11MP0008058_abnormal_DNA_repair2.55788473
12MP0010307_abnormal_tumor_latency2.43683787
13MP0008007_abnormal_cellular_replicative2.42513125
14MP0000350_abnormal_cell_proliferation2.41561970
15MP0005380_embryogenesis_phenotype2.38074587
16MP0001672_abnormal_embryogenesis/_devel2.38074587
17MP0003984_embryonic_growth_retardation2.23865172
18MP0002088_abnormal_embryonic_growth/wei2.21425462
19MP0002396_abnormal_hematopoietic_system2.19676408
20MP0001697_abnormal_embryo_size2.12374747
21MP0003806_abnormal_nucleotide_metabolis2.11927612
22MP0003123_paternal_imprinting2.06298235
23MP0003705_abnormal_hypodermis_morpholog2.00147042
24MP0002084_abnormal_developmental_patter1.96381371
25MP0004808_abnormal_hematopoietic_stem1.93876393
26MP0002086_abnormal_extraembryonic_tissu1.86930043
27MP0002085_abnormal_embryonic_tissue1.85198340
28MP0002080_prenatal_lethality1.84380480
29MP0001849_ear_inflammation1.83154501
30MP0001529_abnormal_vocalization1.76996398
31MP0003121_genomic_imprinting1.67162209
32MP0002653_abnormal_ependyma_morphology1.64606704
33MP0005076_abnormal_cell_differentiation1.57876943
34MP0009840_abnormal_foam_cell1.52389672
35MP0000778_abnormal_nervous_system1.51880188
36MP0004197_abnormal_fetal_growth/weight/1.48890775
37MP0003786_premature_aging1.45413163
38MP0005670_abnormal_white_adipose1.43713872
39MP0008932_abnormal_embryonic_tissue1.43137795
40MP0001915_intracranial_hemorrhage1.39835059
41MP0002697_abnormal_eye_size1.37814293
42MP0003890_abnormal_embryonic-extraembry1.36542352
43MP0004270_analgesia1.35226358
44MP0004264_abnormal_extraembryonic_tissu1.35020481
45MP0001299_abnormal_eye_distance/1.32414069
46MP0002019_abnormal_tumor_incidence1.30574339
47MP0006292_abnormal_olfactory_placode1.27196885
48MP0010030_abnormal_orbit_morphology1.26507547
49MP0003566_abnormal_cell_adhesion1.26233273
50MP0003122_maternal_imprinting1.25398344
51MP0000313_abnormal_cell_death1.25117850
52MP0002210_abnormal_sex_determination1.25028287
53MP0005621_abnormal_cell_physiology1.23910036
54MP0002102_abnormal_ear_morphology1.22941974
55MP0003942_abnormal_urinary_system1.21152967
56MP0003119_abnormal_digestive_system1.20519630
57MP0004133_heterotaxia1.20457886
58MP0002234_abnormal_pharynx_morphology1.19609546
59MP0003567_abnormal_fetal_cardiomyocyte1.18792906
60MP0003699_abnormal_female_reproductive1.18516441
61MP0005384_cellular_phenotype1.16649269
62MP0003763_abnormal_thymus_physiology1.16543425
63MP0003191_abnormal_cellular_cholesterol1.16171723
64MP0000537_abnormal_urethra_morphology1.15740601
65MP0001346_abnormal_lacrimal_gland1.15672023
66MP0006035_abnormal_mitochondrial_morpho1.15532663
67MP0002184_abnormal_innervation1.15309990
68MP0001286_abnormal_eye_development1.14936114
69MP0001929_abnormal_gametogenesis1.14748752
70MP0003941_abnormal_skin_development1.14593471
71MP0001145_abnormal_male_reproductive1.14110042
72MP0000653_abnormal_sex_gland1.13991257
73MP0002938_white_spotting1.13709874
74MP0003755_abnormal_palate_morphology1.13655533
75MP0002233_abnormal_nose_morphology1.12537707
76MP0005397_hematopoietic_system_phenotyp1.11927463
77MP0001545_abnormal_hematopoietic_system1.11927463
78MP0005187_abnormal_penis_morphology1.10924712
79MP0002160_abnormal_reproductive_system1.09389845
80MP0005395_other_phenotype1.09321231
81MP0000703_abnormal_thymus_morphology1.07651370
82MP0001984_abnormal_olfaction1.07157764
83MP0003315_abnormal_perineum_morphology1.07108829
84MP0003385_abnormal_body_wall1.06566343
85MP0005499_abnormal_olfactory_system1.05786918
86MP0005394_taste/olfaction_phenotype1.05786918
87MP0000358_abnormal_cell_content/1.05086654
88MP0009333_abnormal_splenocyte_physiolog1.04121929
89MP0001119_abnormal_female_reproductive1.03304519
90MP0002269_muscular_atrophy1.02275421
91MP0003787_abnormal_imprinting1.00718717
92MP0002398_abnormal_bone_marrow0.99849173
93MP0000955_abnormal_spinal_cord0.99241518
94MP0005266_abnormal_metabolism0.97783876
95MP0003935_abnormal_craniofacial_develop0.97423165
96MP0008789_abnormal_olfactory_epithelium0.97362325
97MP0000579_abnormal_nail_morphology0.96310526
98MP0009053_abnormal_anal_canal0.96307459
99MP0009703_decreased_birth_body0.95487238
100MP0002152_abnormal_brain_morphology0.95487002
101MP0002822_catalepsy0.95314658
102MP0010234_abnormal_vibrissa_follicle0.94984669
103MP0002722_abnormal_immune_system0.93234199
104MP0009672_abnormal_birth_weight0.91820920
105MP0005023_abnormal_wound_healing0.90392385
106MP0002734_abnormal_mechanical_nocicepti0.90347927
107MP0000689_abnormal_spleen_morphology0.90335074
108MP0001188_hyperpigmentation0.90267060
109MP0002081_perinatal_lethality0.89186292
110MP0006276_abnormal_autonomic_nervous0.88350206
111MP0002111_abnormal_tail_morphology0.88295371
112MP0004233_abnormal_muscle_weight0.87256937
113MP0004811_abnormal_neuron_physiology0.87116391
114MP0002272_abnormal_nervous_system0.86920403
115MP0004859_abnormal_synaptic_plasticity0.85965535
116MP0008872_abnormal_physiological_respon0.85690503
117MP0003635_abnormal_synaptic_transmissio0.84365464
118MP0000049_abnormal_middle_ear0.83660235
119MP0001293_anophthalmia0.83490292
120MP0000631_abnormal_neuroendocrine_gland0.83132062
121MP0006072_abnormal_retinal_apoptosis0.82369627
122MP0002009_preneoplasia0.80646789
123MP0003221_abnormal_cardiomyocyte_apopto0.79487996
124MP0009697_abnormal_copulation0.78230518
125MP0002882_abnormal_neuron_morphology0.78128761
126MP0002092_abnormal_eye_morphology0.78031953
127MP0000566_synostosis0.77838836
128MP0008770_decreased_survivor_rate0.77596873
129MP0003136_yellow_coat_color0.77556522
130MP0003861_abnormal_nervous_system0.76600226
131MP0002063_abnormal_learning/memory/cond0.76148547
132MP0009046_muscle_twitch0.76102774
133MP0002557_abnormal_social/conspecific_i0.75715277
134MP0000598_abnormal_liver_morphology0.75662729
135MP0002752_abnormal_somatic_nervous0.74969450
136MP0000569_abnormal_digit_pigmentation0.74376994
137MP0002638_abnormal_pupillary_reflex0.73863779
138MP0002877_abnormal_melanocyte_morpholog0.73829307
139MP0002925_abnormal_cardiovascular_devel0.73630993
140MP0000534_abnormal_ureter_morphology0.73550768
141MP0002116_abnormal_craniofacial_bone0.72699957
142MP0003943_abnormal_hepatobiliary_system0.71561622
143MP0002161_abnormal_fertility/fecundity0.69029367
144MP0005360_urolithiasis0.68763784
145MP0009278_abnormal_bone_marrow0.68716125
146MP0004510_myositis0.68433807
147MP0000609_abnormal_liver_physiology0.66895450
148MP0000428_abnormal_craniofacial_morphol0.63156632
149MP0002429_abnormal_blood_cell0.63136415
150MP0000627_abnormal_mammary_gland0.61736028
151MP0000733_abnormal_muscle_development0.61453843
152MP0000490_abnormal_crypts_of0.60353935
153MP0003937_abnormal_limbs/digits/tail_de0.58465909
154MP0005671_abnormal_response_to0.56375770
155MP0003091_abnormal_cell_migration0.55294600
156MP0003936_abnormal_reproductive_system0.54518283
157MP0000266_abnormal_heart_morphology0.52952118

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.73614312
2Birth length less than 3rd percentile (HP:0003561)3.60519008
3Ependymoma (HP:0002888)3.58411222
4Neoplasm of the oral cavity (HP:0100649)3.45815898
5Impulsivity (HP:0100710)3.34456079
6Facial hemangioma (HP:0000329)3.31349645
7Medulloblastoma (HP:0002885)3.17005206
8Urethral obstruction (HP:0000796)2.99635822
9Breast hypoplasia (HP:0003187)2.99357950
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95650354
11Abnormality of the astrocytes (HP:0100707)2.89594113
12Astrocytoma (HP:0009592)2.89594113
13Neoplasm of striated muscle (HP:0009728)2.89178212
14Rhabdomyosarcoma (HP:0002859)2.86555669
15Abnormality of the fingertips (HP:0001211)2.76999982
16Selective tooth agenesis (HP:0001592)2.76331792
17Prominent nose (HP:0000448)2.73183723
18Abnormality of the lower motor neuron (HP:0002366)2.72683068
19Personality changes (HP:0000751)2.68542915
20Premature ovarian failure (HP:0008209)2.64740628
21Progressive muscle weakness (HP:0003323)2.64475072
22Basal cell carcinoma (HP:0002671)2.59588353
23Delayed puberty (HP:0000823)2.58713970
24Patellar aplasia (HP:0006443)2.55986725
25Type II lissencephaly (HP:0007260)2.52270498
26Hypochromic anemia (HP:0001931)2.51732164
27Anal stenosis (HP:0002025)2.51638663
28Cerebellar dysplasia (HP:0007033)2.50223535
29Thrombocytosis (HP:0001894)2.50082707
30Short 4th metacarpal (HP:0010044)2.49305392
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.49305392
32Abnormal number of incisors (HP:0011064)2.48180760
33Mutism (HP:0002300)2.47538515
34Abnormality of the pons (HP:0007361)2.46230245
35Lip pit (HP:0100267)2.46143006
36Intestinal fistula (HP:0100819)2.42221216
37Abnormal number of erythroid precursors (HP:0012131)2.41707845
38Heterotopia (HP:0002282)2.39598286
39Long eyelashes (HP:0000527)2.38567427
40Cortical dysplasia (HP:0002539)2.37853056
41Spinal muscular atrophy (HP:0007269)2.35989619
42Aplasia/Hypoplasia of the patella (HP:0006498)2.30074611
43Deviation of the thumb (HP:0009603)2.29987427
44Glioma (HP:0009733)2.29435144
45Impaired smooth pursuit (HP:0007772)2.27040662
46Amyotrophic lateral sclerosis (HP:0007354)2.26575492
47Abnormality of cells of the erythroid lineage (HP:0012130)2.25890927
48Proximal placement of thumb (HP:0009623)2.17172265
49Hepatoblastoma (HP:0002884)2.16508706
50Cerebral hypomyelination (HP:0006808)2.13604305
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.13513625
52Increased hepatocellular lipid droplets (HP:0006565)2.12562267
53Volvulus (HP:0002580)2.12200188
54Facial cleft (HP:0002006)2.11468967
55Skin tags (HP:0010609)2.11249112
56Lipid accumulation in hepatocytes (HP:0006561)2.10897287
57Abnormality of the anterior horn cell (HP:0006802)2.09766833
58Degeneration of anterior horn cells (HP:0002398)2.09766833
59Agnosia (HP:0010524)2.09619970
60Acute myeloid leukemia (HP:0004808)2.08368634
61Bifid tongue (HP:0010297)2.08028127
62Carpal bone hypoplasia (HP:0001498)2.07125537
63Abnormality of the antihelix (HP:0009738)2.07014315
64Increased nuchal translucency (HP:0010880)2.06998340
65Myelodysplasia (HP:0002863)2.06712168
66Rectovaginal fistula (HP:0000143)2.06469407
67Rectal fistula (HP:0100590)2.06469407
68Sandal gap (HP:0001852)2.06389879
69Disinhibition (HP:0000734)2.06043668
70High anterior hairline (HP:0009890)2.05015323
71Pancreatic fibrosis (HP:0100732)2.04376624
72Overlapping toe (HP:0001845)2.03856250
73Meckel diverticulum (HP:0002245)2.03804730
74Amaurosis fugax (HP:0100576)2.03139225
75Abnormality of the ileum (HP:0001549)2.02214417
76Broad face (HP:0000283)2.01735789
77Shawl scrotum (HP:0000049)2.01499739
78Molar tooth sign on MRI (HP:0002419)2.01215077
79Abnormality of midbrain morphology (HP:0002418)2.01215077
80Lissencephaly (HP:0001339)2.00559135
81Abnormality of ocular smooth pursuit (HP:0000617)1.99872631
82Optic nerve coloboma (HP:0000588)1.99630494
83Broad palm (HP:0001169)1.99629729
84Capillary hemangiomas (HP:0005306)1.98401980
85Colon cancer (HP:0003003)1.97400160
86Abnormality of chromosome stability (HP:0003220)1.96205569
87Biliary tract neoplasm (HP:0100574)1.95554794
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.94498781
89Diminished motivation (HP:0000745)1.93910382
90Ectopic kidney (HP:0000086)1.93234784
91Global brain atrophy (HP:0002283)1.93026323
92Absent radius (HP:0003974)1.92195090
93Posterior subcapsular cataract (HP:0007787)1.91754507
94Pustule (HP:0200039)1.91639517
95Supernumerary spleens (HP:0009799)1.90876012
96Myelomeningocele (HP:0002475)1.89684168
97Abnormality of the 4th metacarpal (HP:0010012)1.89016259
98* Drooling (HP:0002307)1.88358932
99Oral leukoplakia (HP:0002745)1.86875971
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.86337279
101Neoplasm of the adrenal cortex (HP:0100641)1.86086273
102Abnormality of the carotid arteries (HP:0005344)1.86044741
103Hypoplastic labia majora (HP:0000059)1.85788676
104Spastic diplegia (HP:0001264)1.84658733
105Preauricular skin tag (HP:0000384)1.84590107
106Long clavicles (HP:0000890)1.84088809
107Septate vagina (HP:0001153)1.83807400
108Sloping forehead (HP:0000340)1.82482542
109Preaxial hand polydactyly (HP:0001177)1.80587276
110Hypobetalipoproteinemia (HP:0003563)1.78239049
111Cafe-au-lait spot (HP:0000957)1.77051057
112Chromsome breakage (HP:0040012)1.75890521
113Abnormality of chromosome segregation (HP:0002916)1.75332860
114Hypoplasia of the pons (HP:0012110)1.72419801
115Nephroblastoma (Wilms tumor) (HP:0002667)1.71777705
116Abnormality of the preputium (HP:0100587)1.71706850
117Aplasia involving forearm bones (HP:0009822)1.71457852
118Absent forearm bone (HP:0003953)1.71457852
11911 pairs of ribs (HP:0000878)1.70583030
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70483356
121Vaginal fistula (HP:0004320)1.68846161
122Dyskinesia (HP:0100660)1.68466976
123Nephronophthisis (HP:0000090)1.67834233
124Abnormality of cochlea (HP:0000375)1.67485681
125* Abnormal neuron morphology (HP:0012757)1.67484649
126* Abnormality of the motor neurons (HP:0002450)1.67484649
127Cutis marmorata (HP:0000965)1.67480843
128Underdeveloped nasal alae (HP:0000430)1.66658035
129Reticulocytopenia (HP:0001896)1.66535978
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66514090
131Abnormality of alanine metabolism (HP:0010916)1.66514090
132Hyperalaninemia (HP:0003348)1.66514090
133Low anterior hairline (HP:0000294)1.66335931
134Restlessness (HP:0000711)1.65871194
135Absent thumb (HP:0009777)1.65341871
136Abnormal lung lobation (HP:0002101)1.65060141
137Partial agenesis of the corpus callosum (HP:0001338)1.64209103
138Dandy-Walker malformation (HP:0001305)1.64110493
139Pancreatic cysts (HP:0001737)1.63401014
140Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61876845
141Hypoplasia of the brainstem (HP:0002365)1.61876845
142Horseshoe kidney (HP:0000085)1.61198745
143Obsessive-compulsive behavior (HP:0000722)1.60465074
144Short thumb (HP:0009778)1.57686554
145Progressive inability to walk (HP:0002505)1.57481058
146Chronic hepatic failure (HP:0100626)1.57470524
147Embryonal renal neoplasm (HP:0011794)1.54424205
148Bilateral microphthalmos (HP:0007633)1.53298428
149* Excessive salivation (HP:0003781)1.50127028
150Multiple enchondromatosis (HP:0005701)1.50126270
151Esophageal atresia (HP:0002032)1.50101262
152Protruding tongue (HP:0010808)1.49538649
153EEG with generalized epileptiform discharges (HP:0011198)1.49403888
154Hemivertebrae (HP:0002937)1.48607710
155Pachygyria (HP:0001302)1.47644291
156Meningocele (HP:0002435)1.46095236
157Intestinal atresia (HP:0011100)1.45893715
158Duplication of thumb phalanx (HP:0009942)1.45732603
159Epileptiform EEG discharges (HP:0011182)1.45254034
160Renal duplication (HP:0000075)1.45003512
161Hypoplastic pelvis (HP:0008839)1.44709719
162Hypsarrhythmia (HP:0002521)1.44701502
163Broad-based gait (HP:0002136)1.42768618
164Micropenis (HP:0000054)1.42325106
165Hyperglycinemia (HP:0002154)1.40026388
166Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.39908532
167Absent epiphyses (HP:0010577)1.39908532
168Renovascular hypertension (HP:0100817)1.39898116
169Poor coordination (HP:0002370)1.39810881
170Overriding aorta (HP:0002623)1.39006784
171Retinal dysplasia (HP:0007973)1.38329090
172Small intestinal stenosis (HP:0012848)1.38280247
173Duodenal stenosis (HP:0100867)1.38280247
174Sclerocornea (HP:0000647)1.37722132
175Pendular nystagmus (HP:0012043)1.36539379
176Small hand (HP:0200055)1.35832730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.48379177
2CDC73.97567651
3ACVR1B3.89962682
4MAP3K43.39577275
5ZAK3.33145102
6BUB13.07924522
7MAP2K73.05974822
8TLK12.78944026
9TTK2.68580402
10EEF2K2.66830425
11WEE12.54637080
12NEK22.48887240
13TSSK62.34742057
14STK101.99503680
15NEK11.92385564
16PLK11.78901598
17CHEK21.74934845
18CAMK1G1.71790139
19CAMK1D1.70971106
20BRD41.66902144
21CDK41.65198737
22WNK41.61528896
23CCNB11.58622012
24FRK1.56527210
25TESK21.53490568
26CASK1.52268287
27LATS21.46128632
28MARK11.43424871
29TNIK1.42952715
30ALK1.41264861
31PASK1.41098088
32TAF11.39767744
33MAP3K101.39274250
34ATR1.37082814
35RPS6KB21.36760372
36AURKB1.33029020
37EPHA21.31496577
38LATS11.31476251
39MTOR1.26828048
40MAP2K41.25432628
41CHEK11.25398481
42STK31.25254845
43TAOK11.25056204
44STK161.23114584
45PLK31.21858631
46PLK41.19485772
47MAP3K81.18402573
48BRSK21.18033501
49MELK1.17779169
50STK38L1.17611728
51MKNK21.15120964
52CDK71.14274946
53PKN21.11939660
54CDK21.10948500
55SRPK11.10665593
56AKT31.09464041
57ICK1.05650997
58MAP4K11.03474759
59ATM1.01184744
60EIF2AK11.00789568
61PBK1.00012627
62NTRK10.99023191
63EIF2AK30.97316825
64NME10.96985199
65PIM10.96028825
66CDK60.95941727
67MAPK130.93493166
68RPS6KA40.88208564
69MARK30.88011361
70ERBB40.87284861
71MAP3K30.85619211
72NUAK10.83792099
73ILK0.83504205
74WNK30.83188612
75PDK20.82410935
76AURKA0.82151002
77SIK20.80691569
78DYRK30.79007146
79CDK10.78130149
80TGFBR10.76418413
81CSNK1A1L0.75463979
82BCR0.74858767
83RPS6KB10.74607747
84BMPR1B0.73586384
85BRSK10.72890592
86PAK40.72349378
87PRKAA10.71996608
88MAP2K30.71240385
89CSNK1D0.69306173
90STK390.69285296
91SMG10.67723698
92MST1R0.67584205
93CSNK1E0.67264953
94PHKG20.66695175
95PHKG10.66695175
96CDK80.65912466
97MET0.63210182
98TRIM280.62669853
99HIPK20.59847004
100DYRK20.59817505
101MAPK100.59034156
102RAF10.58205949
103PLK20.57930317
104CHUK0.57843965
105PRKCI0.55020093
106MKNK10.54559013
107MAPKAPK50.54089464
108TYRO30.53639301
109PRKDC0.53126792
110NTRK30.52923248
111CSNK2A20.52772106
112MARK20.51756843
113FGFR20.51432889
114CDK90.51191577
115RPS6KA50.51037985
116PRKCG0.50954773
117MAP3K60.50440078
118RIPK10.50251603
119TTN0.49050562
120SCYL20.48838663
121KDR0.48278199
122MINK10.48215208
123NTRK20.48148302
124MAP3K90.47504428
125CSNK1G10.47033269
126RPS6KA10.46937996
127FGFR10.46676122
128KSR10.46310931
129MAP3K70.46055674
130GSK3B0.45524759
131CAMKK20.44933573
132VRK20.44884965
133EIF2AK20.44861885
134DAPK10.42633002
135MAPK140.42597807
136STK240.42587867
137PDK10.41961026
138CSNK1G20.39956905
139PNCK0.39721409
140BRAF0.38819784
141MAPK10.36914144
142PAK30.36575249
143CSNK1G30.36502969
144TRIB30.35287071
145VRK10.35198075
146FGFR40.34960862
147PDK40.33479702
148PDK30.33479702

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.93628608
2RNA transport_Homo sapiens_hsa030133.78016881
3DNA replication_Homo sapiens_hsa030303.39896875
4Spliceosome_Homo sapiens_hsa030402.99723568
5* RNA polymerase_Homo sapiens_hsa030202.95957664
6Cell cycle_Homo sapiens_hsa041102.91166639
7One carbon pool by folate_Homo sapiens_hsa006702.71978932
8Mismatch repair_Homo sapiens_hsa034302.50698466
9mRNA surveillance pathway_Homo sapiens_hsa030152.41762136
10RNA degradation_Homo sapiens_hsa030182.41169085
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34516681
12Vitamin B6 metabolism_Homo sapiens_hsa007502.02695394
13Basal transcription factors_Homo sapiens_hsa030222.02104184
14Base excision repair_Homo sapiens_hsa034101.90875471
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.89129643
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.80650289
17Nucleotide excision repair_Homo sapiens_hsa034201.77230998
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77093143
19Steroid biosynthesis_Homo sapiens_hsa001001.70283738
20Oocyte meiosis_Homo sapiens_hsa041141.63578045
21Non-homologous end-joining_Homo sapiens_hsa034501.62534182
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.58517635
23Folate biosynthesis_Homo sapiens_hsa007901.53349504
24Nicotine addiction_Homo sapiens_hsa050331.40860334
25* Pyrimidine metabolism_Homo sapiens_hsa002401.39274903
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39002512
27Biosynthesis of amino acids_Homo sapiens_hsa012301.35734231
28mTOR signaling pathway_Homo sapiens_hsa041501.31063936
29p53 signaling pathway_Homo sapiens_hsa041151.30615165
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28049938
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26493202
32Fanconi anemia pathway_Homo sapiens_hsa034601.24476018
33* Epstein-Barr virus infection_Homo sapiens_hsa051691.23670883
34Homologous recombination_Homo sapiens_hsa034401.23272479
35MicroRNAs in cancer_Homo sapiens_hsa052061.20776361
36Proteasome_Homo sapiens_hsa030501.19860207
37Lysine degradation_Homo sapiens_hsa003101.17395040
38Viral carcinogenesis_Homo sapiens_hsa052031.16256981
39Selenocompound metabolism_Homo sapiens_hsa004501.14174022
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.09628674
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09152360
42Alcoholism_Homo sapiens_hsa050341.08580512
43HTLV-I infection_Homo sapiens_hsa051661.05705019
44Chronic myeloid leukemia_Homo sapiens_hsa052201.05647087
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05056039
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.03858350
47Herpes simplex infection_Homo sapiens_hsa051681.00298007
48Huntingtons disease_Homo sapiens_hsa050160.97688945
49Butanoate metabolism_Homo sapiens_hsa006500.97620664
50Protein export_Homo sapiens_hsa030600.97561643
51Colorectal cancer_Homo sapiens_hsa052100.93497637
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93138138
53Basal cell carcinoma_Homo sapiens_hsa052170.91559047
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89138599
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88370989
56* Purine metabolism_Homo sapiens_hsa002300.88025709
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87689860
58Systemic lupus erythematosus_Homo sapiens_hsa053220.84033403
59Wnt signaling pathway_Homo sapiens_hsa043100.82584837
60Hedgehog signaling pathway_Homo sapiens_hsa043400.82571654
61Parkinsons disease_Homo sapiens_hsa050120.82094503
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82032994
63Notch signaling pathway_Homo sapiens_hsa043300.81281944
64Propanoate metabolism_Homo sapiens_hsa006400.80806822
65Oxidative phosphorylation_Homo sapiens_hsa001900.80182177
66Pyruvate metabolism_Homo sapiens_hsa006200.75627167
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73349816
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71863952
69Axon guidance_Homo sapiens_hsa043600.71370616
70Antigen processing and presentation_Homo sapiens_hsa046120.70411089
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66548733
72Small cell lung cancer_Homo sapiens_hsa052220.65735098
73Carbon metabolism_Homo sapiens_hsa012000.65699901
74Arginine and proline metabolism_Homo sapiens_hsa003300.64499384
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.64134866
76T cell receptor signaling pathway_Homo sapiens_hsa046600.63217893
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.63178987
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62607880
79Renal cell carcinoma_Homo sapiens_hsa052110.61363054
80B cell receptor signaling pathway_Homo sapiens_hsa046620.61321740
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60853711
82Non-small cell lung cancer_Homo sapiens_hsa052230.60613967
83Endometrial cancer_Homo sapiens_hsa052130.60311280
84HIF-1 signaling pathway_Homo sapiens_hsa040660.57876209
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57867934
86Acute myeloid leukemia_Homo sapiens_hsa052210.57531076
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57325473
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56965185
89Insulin secretion_Homo sapiens_hsa049110.56525940
90TGF-beta signaling pathway_Homo sapiens_hsa043500.55347828
91Phototransduction_Homo sapiens_hsa047440.53744144
92Dopaminergic synapse_Homo sapiens_hsa047280.53462128
93Thyroid cancer_Homo sapiens_hsa052160.52998136
94Fatty acid biosynthesis_Homo sapiens_hsa000610.52901109
95Glutamatergic synapse_Homo sapiens_hsa047240.52663047
96Alzheimers disease_Homo sapiens_hsa050100.52344169
97Fatty acid metabolism_Homo sapiens_hsa012120.51526795
98Pancreatic cancer_Homo sapiens_hsa052120.50095207
99Glucagon signaling pathway_Homo sapiens_hsa049220.49720059
100N-Glycan biosynthesis_Homo sapiens_hsa005100.49557493
101Arginine biosynthesis_Homo sapiens_hsa002200.49172053
102Hippo signaling pathway_Homo sapiens_hsa043900.48891764
103GABAergic synapse_Homo sapiens_hsa047270.47902444
104ErbB signaling pathway_Homo sapiens_hsa040120.46721726
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46525096
106* Metabolic pathways_Homo sapiens_hsa011000.46105413
107Synaptic vesicle cycle_Homo sapiens_hsa047210.45699103
108Sulfur relay system_Homo sapiens_hsa041220.45220940
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43730892
110Circadian rhythm_Homo sapiens_hsa047100.43536716
111FoxO signaling pathway_Homo sapiens_hsa040680.43033611
112Ribosome_Homo sapiens_hsa030100.42718605
113Pentose phosphate pathway_Homo sapiens_hsa000300.41169308
114Cardiac muscle contraction_Homo sapiens_hsa042600.40844398
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39333441
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39235033
117Thyroid hormone synthesis_Homo sapiens_hsa049180.38768519
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38588904
119Hepatitis B_Homo sapiens_hsa051610.37963859
120Cocaine addiction_Homo sapiens_hsa050300.37781108
121Prostate cancer_Homo sapiens_hsa052150.37523200
122Primary immunodeficiency_Homo sapiens_hsa053400.37261591
123Melanoma_Homo sapiens_hsa052180.37022162
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36040956
125Type II diabetes mellitus_Homo sapiens_hsa049300.34525861
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34336864
127Choline metabolism in cancer_Homo sapiens_hsa052310.33810912
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33088547
129Inositol phosphate metabolism_Homo sapiens_hsa005620.32598177
130Fatty acid elongation_Homo sapiens_hsa000620.32595195
131Taste transduction_Homo sapiens_hsa047420.31569206
132Prolactin signaling pathway_Homo sapiens_hsa049170.30892701
133Influenza A_Homo sapiens_hsa051640.30735314
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30701032
135Proteoglycans in cancer_Homo sapiens_hsa052050.28701064
136Insulin resistance_Homo sapiens_hsa049310.28437232
137Vitamin digestion and absorption_Homo sapiens_hsa049770.28434114
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28368768
139Measles_Homo sapiens_hsa051620.27886758
140Caffeine metabolism_Homo sapiens_hsa002320.27828908
141Pathways in cancer_Homo sapiens_hsa052000.26010390
142Apoptosis_Homo sapiens_hsa042100.23904554
143Dorso-ventral axis formation_Homo sapiens_hsa043200.23702050
144Adherens junction_Homo sapiens_hsa045200.23619327

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »