POLR3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.17415250
2nuclear pore complex assembly (GO:0051292)5.09604780
3protein localization to kinetochore (GO:0034501)4.78905156
4folic acid-containing compound biosynthetic process (GO:0009396)4.77417462
5mitotic nuclear envelope disassembly (GO:0007077)4.73131655
6DNA unwinding involved in DNA replication (GO:0006268)4.43783859
7membrane disassembly (GO:0030397)4.40368926
8nuclear envelope disassembly (GO:0051081)4.40368926
9pre-miRNA processing (GO:0031054)4.23419883
10IMP biosynthetic process (GO:0006188)4.16430964
11establishment of integrated proviral latency (GO:0075713)4.04884254
12nucleobase biosynthetic process (GO:0046112)4.00968297
13mitotic sister chromatid cohesion (GO:0007064)3.92933114
14somatic diversification of immune receptors via somatic mutation (GO:0002566)3.91238702
15somatic hypermutation of immunoglobulin genes (GO:0016446)3.91238702
16protein localization to chromosome, centromeric region (GO:0071459)3.90768756
17regulation of histone H3-K9 methylation (GO:0051570)3.86236041
18regulation of RNA export from nucleus (GO:0046831)3.83898355
19pore complex assembly (GO:0046931)3.80073360
20DNA replication initiation (GO:0006270)3.79826526
21DNA duplex unwinding (GO:0032508)3.78530044
22DNA strand elongation involved in DNA replication (GO:0006271)3.77614310
23DNA geometric change (GO:0032392)3.77556181
24DNA replication-dependent nucleosome assembly (GO:0006335)3.77478315
25DNA replication-dependent nucleosome organization (GO:0034723)3.77478315
26formation of translation preinitiation complex (GO:0001731)3.76722566
27purine nucleobase biosynthetic process (GO:0009113)3.76579539
28CENP-A containing nucleosome assembly (GO:0034080)3.71224627
29IMP metabolic process (GO:0046040)3.65536158
30regulation of translational fidelity (GO:0006450)3.64661433
31DNA strand elongation (GO:0022616)3.64430561
32double-strand break repair via nonhomologous end joining (GO:0006303)3.62268657
33non-recombinational repair (GO:0000726)3.62268657
34negative regulation of histone methylation (GO:0031061)3.59958154
35mitotic chromosome condensation (GO:0007076)3.55460711
36mitochondrial RNA metabolic process (GO:0000959)3.54736462
37nuclear envelope organization (GO:0006998)3.50144710
38mitotic metaphase plate congression (GO:0007080)3.50052274
39positive regulation of chromosome segregation (GO:0051984)3.48803203
40DNA replication checkpoint (GO:0000076)3.47122491
41sister chromatid segregation (GO:0000819)3.46849155
42mitotic sister chromatid segregation (GO:0000070)3.46478723
43telomere maintenance via semi-conservative replication (GO:0032201)3.41977415
44regulation of gene silencing by RNA (GO:0060966)3.41588132
45regulation of posttranscriptional gene silencing (GO:0060147)3.41588132
46regulation of gene silencing by miRNA (GO:0060964)3.41588132
47regulation of mitochondrial translation (GO:0070129)3.40921725
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32907355
49DNA ligation (GO:0006266)3.32817189
50regulation of spindle organization (GO:0090224)3.32569244
51attachment of spindle microtubules to kinetochore (GO:0008608)3.32201626
52meiotic chromosome segregation (GO:0045132)3.29462418
53metaphase plate congression (GO:0051310)3.27741832
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.24322834
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24322834
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24322834
57regulation of DNA endoreduplication (GO:0032875)3.19608417
58mitotic recombination (GO:0006312)3.19318823
59tRNA aminoacylation (GO:0043039)3.14767274
60amino acid activation (GO:0043038)3.14767274
61telomere maintenance via recombination (GO:0000722)3.14401475
62tRNA aminoacylation for protein translation (GO:0006418)3.13897226
63heterochromatin organization (GO:0070828)3.13565015
64histone exchange (GO:0043486)3.13268591
65transcription from mitochondrial promoter (GO:0006390)3.12223960
66regulation of mitotic spindle organization (GO:0060236)3.11010581
67kinetochore organization (GO:0051383)3.09235006
68regulation of sister chromatid cohesion (GO:0007063)3.08609289
69dosage compensation (GO:0007549)3.08324156
70negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07767589
71DNA damage response, detection of DNA damage (GO:0042769)3.06246296
72synapsis (GO:0007129)3.05997951
73ribosome biogenesis (GO:0042254)3.05010903
74proteasome assembly (GO:0043248)3.03800690
75spindle checkpoint (GO:0031577)3.02621709
76DNA conformation change (GO:0071103)3.00117453
77translesion synthesis (GO:0019985)2.99729018
78snRNA processing (GO:0016180)2.99435600
79protein K6-linked ubiquitination (GO:0085020)2.98337487
80regulation of helicase activity (GO:0051095)2.97615086
81DNA topological change (GO:0006265)2.96782794
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96552087
83protein localization to chromosome (GO:0034502)2.96401104
84mRNA transport (GO:0051028)2.96183131
85chromatin assembly (GO:0031497)2.94656381
86kinetochore assembly (GO:0051382)2.92833674
87chromosome segregation (GO:0007059)2.92107648
88snRNA metabolic process (GO:0016073)2.91988456
89DNA catabolic process, exonucleolytic (GO:0000738)2.91688000
90mitotic spindle checkpoint (GO:0071174)2.90562333
91regulation of nucleobase-containing compound transport (GO:0032239)2.89335921
92regulation of centrosome cycle (GO:0046605)2.88671203
93DNA replication-independent nucleosome organization (GO:0034724)2.88427527
94DNA replication-independent nucleosome assembly (GO:0006336)2.88427527
95tetrahydrofolate metabolic process (GO:0046653)2.88385402
96chromatin assembly or disassembly (GO:0006333)2.87862533
97ribosome assembly (GO:0042255)2.87588990
98cullin deneddylation (GO:0010388)2.87551214
99histone H2A monoubiquitination (GO:0035518)2.86799138
100establishment of chromosome localization (GO:0051303)2.85833346
101spliceosomal tri-snRNP complex assembly (GO:0000244)2.85288540
102postreplication repair (GO:0006301)2.84959137
103nucleotide-excision repair, DNA gap filling (GO:0006297)2.83691648
104telomere maintenance via telomere lengthening (GO:0010833)2.82887853
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82858704
106negative regulation of RNA splicing (GO:0033119)2.81656841
107regulation of chromosome segregation (GO:0051983)2.81323906
108regulation of centriole replication (GO:0046599)2.80709997
109mitotic G1 DNA damage checkpoint (GO:0031571)2.79970572
110regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78062168
111regulation of mitotic spindle checkpoint (GO:1903504)2.78062168
112negative regulation of chromosome segregation (GO:0051985)2.77558696
113chromatin remodeling at centromere (GO:0031055)2.77478070
114mismatch repair (GO:0006298)2.77310381
115maturation of SSU-rRNA (GO:0030490)2.76278776
116negative regulation of mitotic sister chromatid separation (GO:2000816)2.75607528
117negative regulation of sister chromatid segregation (GO:0033046)2.75607528
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75607528
119negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75607528
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75607528
121regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75552455
122regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75552455
123somatic recombination of immunoglobulin gene segments (GO:0016447)2.74229685
124regulation of gene silencing (GO:0060968)2.74153836
125telomere maintenance (GO:0000723)2.74067804
126replication fork processing (GO:0031297)2.73927548
127regulation of DNA damage checkpoint (GO:2000001)2.73613300
128telomere organization (GO:0032200)2.72959310
129determination of adult lifespan (GO:0008340)2.72118816
130RNA transport (GO:0050658)2.71079298
131establishment of RNA localization (GO:0051236)2.71079298
132nucleic acid transport (GO:0050657)2.71079298
133DNA double-strand break processing (GO:0000729)2.70779166
134regulation of telomere maintenance via telomerase (GO:0032210)2.69997100
135ribonucleoprotein complex biogenesis (GO:0022613)2.69422827
136establishment of viral latency (GO:0019043)2.69285293
137regulation of translational termination (GO:0006449)2.69194326
138glucocorticoid receptor signaling pathway (GO:0042921)2.68924952
139rRNA processing (GO:0006364)2.68648181
140sister chromatid cohesion (GO:0007062)2.68225409
141spindle assembly checkpoint (GO:0071173)2.67720381
142ATP-dependent chromatin remodeling (GO:0043044)2.67633541
143anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67026315
144mitotic spindle assembly checkpoint (GO:0007094)2.66446884
145spliceosomal snRNP assembly (GO:0000387)2.66201670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.62228996
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.50018856
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64210868
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.47394198
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.05550461
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98347192
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93783509
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55114988
9MYC_22102868_ChIP-Seq_BL_Human2.41631724
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35891161
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33074670
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12096786
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10896956
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.08721741
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08353965
16AR_21909140_ChIP-Seq_LNCAP_Human1.92085038
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91794119
18XRN2_22483619_ChIP-Seq_HELA_Human1.88033198
19CIITA_25753668_ChIP-Seq_RAJI_Human1.86658843
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.84386366
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80957884
22* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78571631
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78337809
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76649822
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75443971
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.74557214
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71028642
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68195887
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68160225
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67091111
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.65331744
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62180547
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60007844
34FOXP3_21729870_ChIP-Seq_TREG_Human1.57201618
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56924580
36* VDR_23849224_ChIP-Seq_CD4+_Human1.56259414
37KDM5A_27292631_Chip-Seq_BREAST_Human1.55651200
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55167144
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54883862
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52165616
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.51273322
42* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51246456
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50920463
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49107428
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48885717
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47130988
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47029828
48FUS_26573619_Chip-Seq_HEK293_Human1.46571931
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.45242419
50EWS_26573619_Chip-Seq_HEK293_Human1.41990257
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41703198
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41703198
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41703198
54* GABP_19822575_ChIP-Seq_HepG2_Human1.40808563
55VDR_21846776_ChIP-Seq_THP-1_Human1.40161829
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38154526
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34388108
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34324267
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.34098489
60TFEB_21752829_ChIP-Seq_HELA_Human1.30059524
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27397126
62* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26525230
63DCP1A_22483619_ChIP-Seq_HELA_Human1.26228475
64TTF2_22483619_ChIP-Seq_HELA_Human1.23976328
65ELK1_19687146_ChIP-ChIP_HELA_Human1.23633379
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20994925
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18867723
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18120213
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17708715
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16652068
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15769961
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15349142
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15262696
74ZNF274_21170338_ChIP-Seq_K562_Hela1.15118985
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.14865814
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13965001
77* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12910595
78* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12050059
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10453904
80MYC_18940864_ChIP-ChIP_HL60_Human1.09488383
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08623307
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08527990
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07869731
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.06400697
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06113148
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06069332
87* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05584554
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03947685
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03073229
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03009367
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.02943931
92* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02866395
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01071168
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00671738
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00221988
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00012658
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97985552
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97428986
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97342267
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.96874669
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96134371
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95757231
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95122765
104MYB_26560356_Chip-Seq_TH1_Human0.94017676
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93485268
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93388868
107TCF7_22412390_ChIP-Seq_EML_Mouse0.93277379
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92525679
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92351681
110VDR_22108803_ChIP-Seq_LS180_Human0.92151605
111* UTX_26944678_Chip-Seq_JUKART_Human0.92126800
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91943281
113MYB_26560356_Chip-Seq_TH2_Human0.91599659
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91503008
115* MAF_26560356_Chip-Seq_TH1_Human0.89851691
116* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89423163
117CHD1_26751641_Chip-Seq_LNCaP_Human0.88474358
118* SPI1_23547873_ChIP-Seq_NB4_Human0.88112051
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.87476686
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87279401
121YY1_21170310_ChIP-Seq_MESCs_Mouse0.87120057
122TAF15_26573619_Chip-Seq_HEK293_Human0.86344460
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.85645963
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83673441
125POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82554096
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76227357
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75696852
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74781639
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.74592925
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73919818
131ELF5_23300383_ChIP-Seq_T47D_Human0.71419159
132TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71050313
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.69547273
134IGF1R_20145208_ChIP-Seq_DFB_Human0.69529853
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.69118537
136GATA4_21415370_ChIP-Seq_HL-1_Mouse0.67795948
137CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.67414057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.25031147
2MP0010094_abnormal_chromosome_stability3.93295920
3MP0003693_abnormal_embryo_hatching3.86421528
4MP0003111_abnormal_nucleus_morphology3.79342712
5MP0004957_abnormal_blastocyst_morpholog3.59601879
6MP0003077_abnormal_cell_cycle3.50902749
7MP0010352_gastrointestinal_tract_polyps2.84021249
8MP0008058_abnormal_DNA_repair2.73404226
9MP0009697_abnormal_copulation2.72793926
10MP0010307_abnormal_tumor_latency2.52986148
11MP0003718_maternal_effect2.47176695
12MP0001730_embryonic_growth_arrest2.41648863
13MP0002396_abnormal_hematopoietic_system2.36278876
14MP0005076_abnormal_cell_differentiation2.35783912
15MP0008007_abnormal_cellular_replicative2.34961578
16MP0000350_abnormal_cell_proliferation2.32724480
17MP0003941_abnormal_skin_development2.27654955
18MP0000569_abnormal_digit_pigmentation2.18013736
19MP0002102_abnormal_ear_morphology1.98772354
20MP0008877_abnormal_DNA_methylation1.91152652
21MP0001672_abnormal_embryogenesis/_devel1.88952541
22MP0005380_embryogenesis_phenotype1.88952541
23MP0004197_abnormal_fetal_growth/weight/1.83992996
24MP0001697_abnormal_embryo_size1.82384886
25MP0003890_abnormal_embryonic-extraembry1.82097237
26MP0003984_embryonic_growth_retardation1.80647609
27MP0002088_abnormal_embryonic_growth/wei1.78041418
28MP0002086_abnormal_extraembryonic_tissu1.76981118
29MP0008932_abnormal_embryonic_tissue1.75380783
30MP0002084_abnormal_developmental_patter1.74498676
31MP0006054_spinal_hemorrhage1.71586798
32MP0006035_abnormal_mitochondrial_morpho1.71231328
33MP0004808_abnormal_hematopoietic_stem1.66252369
34MP0002085_abnormal_embryonic_tissue1.64895079
35MP0004233_abnormal_muscle_weight1.64715249
36MP0001661_extended_life_span1.62764162
37MP0002080_prenatal_lethality1.60416712
38MP0003123_paternal_imprinting1.57485902
39MP0003705_abnormal_hypodermis_morpholog1.57346722
40MP0003950_abnormal_plasma_membrane1.56566659
41MP0000490_abnormal_crypts_of1.53419681
42MP0002019_abnormal_tumor_incidence1.48699551
43MP0003566_abnormal_cell_adhesion1.43042314
44MP0002160_abnormal_reproductive_system1.40080050
45MP0000313_abnormal_cell_death1.37913411
46MP0004264_abnormal_extraembryonic_tissu1.34074867
47MP0000703_abnormal_thymus_morphology1.33454765
48MP0003806_abnormal_nucleotide_metabolis1.29930796
49MP0003786_premature_aging1.29352932
50MP0003121_genomic_imprinting1.27253213
51MP0002877_abnormal_melanocyte_morpholog1.27171825
52MP0002398_abnormal_bone_marrow1.26248351
53MP0001849_ear_inflammation1.22836244
54MP0001915_intracranial_hemorrhage1.22353257
55MP0003763_abnormal_thymus_physiology1.21062030
56MP0003567_abnormal_fetal_cardiomyocyte1.20209302
57MP0000427_abnormal_hair_cycle1.19955648
58MP0009053_abnormal_anal_canal1.14963893
59MP0000647_abnormal_sebaceous_gland1.14738183
60MP0002722_abnormal_immune_system1.13694599
61MP0001545_abnormal_hematopoietic_system1.13379643
62MP0005397_hematopoietic_system_phenotyp1.13379643
63MP0000689_abnormal_spleen_morphology1.11225204
64MP0001529_abnormal_vocalization1.09550196
65MP0009703_decreased_birth_body1.09449743
66MP0003755_abnormal_palate_morphology1.07899029
67MP0009672_abnormal_birth_weight1.07653836
68MP0009278_abnormal_bone_marrow1.02956359
69MP0003119_abnormal_digestive_system1.01351110
70MP0001293_anophthalmia1.01316832
71MP0005451_abnormal_body_composition1.00212699
72MP0000371_diluted_coat_color1.00059859
73MP0005023_abnormal_wound_healing0.99971008
74MP0002234_abnormal_pharynx_morphology0.99344052
75MP0006292_abnormal_olfactory_placode0.97696678
76MP0002233_abnormal_nose_morphology0.97448604
77MP0000537_abnormal_urethra_morphology0.97031502
78MP0003221_abnormal_cardiomyocyte_apopto0.96751552
79MP0005395_other_phenotype0.94422845
80MP0000383_abnormal_hair_follicle0.93591544
81MP0008995_early_reproductive_senescence0.93176298
82MP0006036_abnormal_mitochondrial_physio0.92837081
83MP0002166_altered_tumor_susceptibility0.91514625
84MP0009333_abnormal_splenocyte_physiolog0.91003283
85MP0000858_altered_metastatic_potential0.90975155
86MP0002429_abnormal_blood_cell0.89282578
87MP0002269_muscular_atrophy0.88561329
88MP0001800_abnormal_humoral_immune0.86986687
89MP0005621_abnormal_cell_physiology0.86703140
90MP0001299_abnormal_eye_distance/0.86615768
91MP0003300_gastrointestinal_ulcer0.86209522
92MP0005384_cellular_phenotype0.83923291
93MP0000716_abnormal_immune_system0.81742426
94MP0008789_abnormal_olfactory_epithelium0.81651280
95MP0002925_abnormal_cardiovascular_devel0.81491325
96MP0005408_hypopigmentation0.79591211
97MP0005187_abnormal_penis_morphology0.79353540
98MP0010030_abnormal_orbit_morphology0.79148476
99MP0002210_abnormal_sex_determination0.78185742
100MP0000579_abnormal_nail_morphology0.77471142
101MP0006072_abnormal_retinal_apoptosis0.77302977
102MP0001145_abnormal_male_reproductive0.76866580
103MP0002006_tumorigenesis0.76640069
104MP0010678_abnormal_skin_adnexa0.75932104
105MP0001119_abnormal_female_reproductive0.74805469
106MP0003385_abnormal_body_wall0.74090787
107MP0002092_abnormal_eye_morphology0.74016372
108MP0000762_abnormal_tongue_morphology0.73944491
109MP0003868_abnormal_feces_composition0.73671118
110MP0005623_abnormal_meninges_morphology0.72663629
111MP0000733_abnormal_muscle_development0.72462515
112MP0003943_abnormal_hepatobiliary_system0.72013853
113MP0003861_abnormal_nervous_system0.71674787
114MP0005389_reproductive_system_phenotype0.71458977
115MP0005257_abnormal_intraocular_pressure0.69848313
116MP0000358_abnormal_cell_content/0.69634502
117MP0003699_abnormal_female_reproductive0.68993759
118MP0002405_respiratory_system_inflammati0.68725311
119MP0002697_abnormal_eye_size0.68500046
120MP0002796_impaired_skin_barrier0.68243835
121MP0002111_abnormal_tail_morphology0.68201590
122MP0000477_abnormal_intestine_morphology0.67526293
123MP0003698_abnormal_male_reproductive0.66285411
124MP0000428_abnormal_craniofacial_morphol0.66182339
125MP0005174_abnormal_tail_pigmentation0.64976115
126MP0002938_white_spotting0.64773556
127MP0002177_abnormal_outer_ear0.64693214
128MP0000432_abnormal_head_morphology0.64678551
129MP0009250_abnormal_appendicular_skeleto0.63781764
130MP0000377_abnormal_hair_follicle0.63313976
131MP0003448_altered_tumor_morphology0.63107252
132MP0001929_abnormal_gametogenesis0.62912700
133MP0002420_abnormal_adaptive_immunity0.62078716
134MP0002075_abnormal_coat/hair_pigmentati0.61760195
135MP0003935_abnormal_craniofacial_develop0.61723577
136MP0004185_abnormal_adipocyte_glucose0.61039810
137MP0000653_abnormal_sex_gland0.61024731
138MP0001286_abnormal_eye_development0.60752531
139MP0000627_abnormal_mammary_gland0.60540693
140MP0001819_abnormal_immune_cell0.60389614
141MP0000631_abnormal_neuroendocrine_gland0.60249042
142MP0003937_abnormal_limbs/digits/tail_de0.59947860
143MP0000598_abnormal_liver_morphology0.59938667
144MP0002161_abnormal_fertility/fecundity0.59572916
145MP0002452_abnormal_antigen_presenting0.59451451
146MP0008770_decreased_survivor_rate0.59168487
147MP0000266_abnormal_heart_morphology0.59030218
148MP0004134_abnormal_chest_morphology0.58915099
149MP0000685_abnormal_immune_system0.58393443

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.87500230
2Medulloblastoma (HP:0002885)3.92259673
3Abnormality of the astrocytes (HP:0100707)3.80624676
4Astrocytoma (HP:0009592)3.80624676
5Rhabdomyosarcoma (HP:0002859)3.70670503
6Colon cancer (HP:0003003)3.46955409
7Degeneration of anterior horn cells (HP:0002398)3.28970892
8Abnormality of the anterior horn cell (HP:0006802)3.28970892
9Chromsome breakage (HP:0040012)3.21126934
10Agnosia (HP:0010524)3.20800797
11Glioma (HP:0009733)3.14699178
12Volvulus (HP:0002580)3.06772911
13Neoplasm of striated muscle (HP:0009728)2.99069268
14Abnormality of chromosome stability (HP:0003220)2.94293016
15Basal cell carcinoma (HP:0002671)2.91804511
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88102620
17Microvesicular hepatic steatosis (HP:0001414)2.86484106
18Abnormality of the fingertips (HP:0001211)2.80087048
19Papillary thyroid carcinoma (HP:0002895)2.77156227
20Neoplasm of the oral cavity (HP:0100649)2.75902907
21Birth length less than 3rd percentile (HP:0003561)2.75591469
22Selective tooth agenesis (HP:0001592)2.74610314
23Biliary tract neoplasm (HP:0100574)2.67016485
24Myelodysplasia (HP:0002863)2.63016727
25Amaurosis fugax (HP:0100576)2.62164191
26Increased serum pyruvate (HP:0003542)2.55569095
27Deviation of the thumb (HP:0009603)2.55024709
28Proximal placement of thumb (HP:0009623)2.54862138
29Impulsivity (HP:0100710)2.52229231
30Abnormality of the labia minora (HP:0012880)2.50393002
31Prominent nose (HP:0000448)2.46887790
32Facial hemangioma (HP:0000329)2.46603008
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.44495864
34Abnormality of glycolysis (HP:0004366)2.43584543
35Angiofibromas (HP:0010615)2.42400971
36Adenoma sebaceum (HP:0009720)2.42400971
37Septate vagina (HP:0001153)2.41712546
38Cafe-au-lait spot (HP:0000957)2.41283779
39Increased nuchal translucency (HP:0010880)2.39078292
40Meckel diverticulum (HP:0002245)2.37963540
41Abnormality of the ileum (HP:0001549)2.35966264
42Patellar aplasia (HP:0006443)2.33561579
43Abnormality of the preputium (HP:0100587)2.33043534
44Abnormality of alanine metabolism (HP:0010916)2.32890630
45Hyperalaninemia (HP:0003348)2.32890630
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32890630
47Ectopic kidney (HP:0000086)2.30590721
48Spinal muscular atrophy (HP:0007269)2.28304047
49Oligodactyly (hands) (HP:0001180)2.27194462
50Absent thumb (HP:0009777)2.23017699
51Heterotopia (HP:0002282)2.22333396
52Nephroblastoma (Wilms tumor) (HP:0002667)2.21889926
53Overlapping toe (HP:0001845)2.19316252
54Neoplasm of the rectum (HP:0100743)2.19175319
55Missing ribs (HP:0000921)2.18107168
56High pitched voice (HP:0001620)2.17739274
57Embryonal renal neoplasm (HP:0011794)2.16646956
58Acute necrotizing encephalopathy (HP:0006965)2.16339163
59Neoplasm of the pancreas (HP:0002894)2.15885571
60Neoplasm of the small intestine (HP:0100833)2.15839529
6111 pairs of ribs (HP:0000878)2.11883956
62Reticulocytopenia (HP:0001896)2.11789835
63Acute encephalopathy (HP:0006846)2.11763881
64Oral leukoplakia (HP:0002745)2.10286270
65Aplasia/hypoplasia of the humerus (HP:0006507)2.08690214
66Aplasia/Hypoplasia of the patella (HP:0006498)2.08323547
67Cerebral edema (HP:0002181)2.07785314
68Gastrointestinal carcinoma (HP:0002672)2.07467896
69Malignant gastrointestinal tract tumors (HP:0006749)2.07467896
70Increased CSF lactate (HP:0002490)2.06982058
71Amniotic constriction ring (HP:0009775)2.06964083
72Abnormality of placental membranes (HP:0011409)2.06964083
73Short humerus (HP:0005792)2.04474326
74Neoplasm of the colon (HP:0100273)2.01277443
75Small intestinal stenosis (HP:0012848)2.01057301
76Duodenal stenosis (HP:0100867)2.01057301
77Thrombocytosis (HP:0001894)2.00877895
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.00345986
79Long eyelashes (HP:0000527)2.00336922
80Rib fusion (HP:0000902)2.00065378
81Abnormal lung lobation (HP:0002101)1.99069662
82Absent forearm bone (HP:0003953)1.95756904
83Short 4th metacarpal (HP:0010044)1.95512163
84Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95512163
85Horseshoe kidney (HP:0000085)1.94784281
86Abnormal mitochondria in muscle tissue (HP:0008316)1.94496108
87Abnormality of the carotid arteries (HP:0005344)1.94266067
88Ovarian neoplasm (HP:0100615)1.94094331
89Cutaneous melanoma (HP:0012056)1.93915525
90Abnormal biliary tract morphology (HP:0012440)1.93701227
91Progressive external ophthalmoplegia (HP:0000590)1.93478806
92Breast hypoplasia (HP:0003187)1.92521091
93Increased serum lactate (HP:0002151)1.92287367
94Abnormality of pyrimidine metabolism (HP:0004353)1.89938354
95Squamous cell carcinoma (HP:0002860)1.89552996
96Bone marrow hypocellularity (HP:0005528)1.88908461
97Acute lymphatic leukemia (HP:0006721)1.88820976
98Uterine neoplasm (HP:0010784)1.88381989
99Abnormal number of incisors (HP:0011064)1.87545882
100Absent radius (HP:0003974)1.87480942
101Lymphoma (HP:0002665)1.87228490
102Abnormality of methionine metabolism (HP:0010901)1.86603819
103Sloping forehead (HP:0000340)1.83439419
104Hypoplastic labia majora (HP:0000059)1.82520909
105Broad palm (HP:0001169)1.82255096
106* Horizontal nystagmus (HP:0000666)1.82195820
107Deep philtrum (HP:0002002)1.82132168
108Intestinal polyposis (HP:0200008)1.81328259
109Sparse lateral eyebrow (HP:0005338)1.81210610
110Aplastic anemia (HP:0001915)1.81098826
111Hepatic necrosis (HP:0002605)1.81032732
112Central scotoma (HP:0000603)1.80693900
113Hyperacusis (HP:0010780)1.80618789
114Intestinal polyp (HP:0005266)1.79906394
115Acute myeloid leukemia (HP:0004808)1.78138146
116Hepatocellular necrosis (HP:0001404)1.77988803
117Cortical dysplasia (HP:0002539)1.77373588
118Fibrous tissue neoplasm (HP:0012316)1.77340893
119Gonadotropin excess (HP:0000837)1.77112622
120Sandal gap (HP:0001852)1.76182868
121Benign neoplasm of the central nervous system (HP:0100835)1.75724398
122Anal stenosis (HP:0002025)1.75688237
123Premature graying of hair (HP:0002216)1.75006351
124Increased hepatocellular lipid droplets (HP:0006565)1.74435119
125Cutis marmorata (HP:0000965)1.73525040
126Oligodactyly (HP:0012165)1.73379817
127Abnormality of the labia (HP:0000058)1.73145354
128Thyroid carcinoma (HP:0002890)1.72978379
129Truncal obesity (HP:0001956)1.72200717
130Abnormality of the duodenum (HP:0002246)1.72006157
131Freckling (HP:0001480)1.71920559
132Type I transferrin isoform profile (HP:0003642)1.71052182
133Abnormality of the calcaneus (HP:0008364)1.70539749
134Multiple enchondromatosis (HP:0005701)1.70464642
135Lipid accumulation in hepatocytes (HP:0006561)1.70281936
136Tracheoesophageal fistula (HP:0002575)1.69920255
137Hypoplastic pelvis (HP:0008839)1.68473407
138Hypokinesia (HP:0002375)1.67896483
139Fibroma (HP:0010614)1.67116280
140T lymphocytopenia (HP:0005403)1.66135984
141Aplasia involving forearm bones (HP:0009822)1.66009103
142Renal cortical cysts (HP:0000803)1.64144240
143Aplasia/Hypoplasia involving the musculature (HP:0001460)1.64088198
144Abnormality of the labia majora (HP:0012881)1.62452401
145Premature ovarian failure (HP:0008209)1.62020450
146Hypoplastic female external genitalia (HP:0012815)1.61745407
147Abnormal auditory evoked potentials (HP:0006958)1.61453583
148Progressive macrocephaly (HP:0004481)1.59823635
149Tubulointerstitial nephritis (HP:0001970)1.59698798
150Abnormality of serum amino acid levels (HP:0003112)1.58212308
151Choanal atresia (HP:0000453)1.56894310
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.55788727
153Abnormal protein N-linked glycosylation (HP:0012347)1.55788727
154Abnormal protein glycosylation (HP:0012346)1.55788727
155Abnormal glycosylation (HP:0012345)1.55788727
156Postnatal growth retardation (HP:0008897)1.54568566
157Hypobetalipoproteinemia (HP:0003563)1.54305103
158Cystic hygroma (HP:0000476)1.53049155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.00924233
2CDK123.84746534
3MAP3K103.60996169
4WEE13.34351103
5STK102.90460702
6PBK2.57348583
7NEK22.51705820
8BUB12.43793887
9BRSK22.41622808
10EEF2K2.41130068
11TRIM282.28821604
12PNCK2.01718862
13SRPK11.97770837
14FLT31.93160258
15TTK1.89742902
16EIF2AK11.89258369
17TSSK61.82863662
18NEK11.81681304
19PKN21.80105311
20MST41.79852626
21NEK91.79814835
22PDK21.78317946
23RPS6KB21.77716459
24ACVR1B1.75545726
25ATR1.68748335
26MAP3K81.65090737
27MAP4K21.57896463
28CDK71.57271639
29PASK1.52567666
30PLK11.51354598
31TGFBR11.48370682
32MAP3K121.46820220
33CDK41.41821190
34DYRK31.41548131
35BRD41.39590951
36AURKB1.26957673
37CHEK11.26622598
38LRRK21.26178069
39CAMK1G1.25248138
40WNK31.23526192
41RPS6KA41.22724599
42EPHA21.21352201
43CHEK21.21285442
44PLK31.20172811
45MST1R1.19672868
46MAP4K11.16501789
47TLK11.14426785
48BCR1.11084558
49ALK1.09728593
50STK41.08960169
51BRSK11.07342094
52CDK61.06819101
53STK31.06761609
54PIM11.03964398
55VRK11.02805087
56PLK41.02326213
57MTOR1.01659050
58ATM1.00639909
59MAP3K41.00628141
60NME10.98943542
61STK160.95061354
62TRIB30.94185285
63CDK20.93762864
64SCYL20.93092120
65MELK0.90949508
66PAK40.88678635
67PTK60.87540255
68EIF2AK20.86490294
69GRK60.84825824
70STK38L0.82827032
71MKNK10.82464307
72JAK30.81173884
73NEK60.79682063
74TESK20.78466299
75CCNB10.78020620
76MKNK20.77981863
77ERBB30.72361988
78PIK3CG0.72252917
79AURKA0.69799638
80CAMK1D0.69013652
81ZAP700.67936886
82FGFR40.66534647
83STK390.65713824
84LATS10.65231915
85PDGFRA0.64701885
86NUAK10.64640349
87ERBB40.63891537
88EPHB10.63204226
89VRK20.62959409
90ZAK0.62012618
91CLK10.61651957
92CDK10.61299999
93RAF10.61213786
94NLK0.59472676
95BTK0.59159293
96TAF10.58653770
97MAP2K30.54397520
98CSF1R0.52797677
99CDK90.52242253
100LATS20.51624987
101CSNK2A20.51383355
102MAPK110.50520598
103ITK0.50189331
104ERN10.49936162
105PLK20.49494323
106CSNK1D0.49095293
107TTN0.47728722
108MET0.44957241
109CSK0.44482177
110EIF2AK30.44160152
111CSNK1G10.43482469
112CHUK0.43329304
113CSNK1A1L0.43089583
114MAP3K50.42895421
115RPS6KA10.42782213
116KSR10.42527180
117MINK10.42419763
118RPS6KB10.42042139
119WNK40.41030154
120EPHA30.40583861
121CSNK1E0.40557058
122MAPK140.40287214
123MAP2K70.40142454
124OBSCN0.38789596
125CDK80.38144586
126FGFR10.37362577
127AKT30.36956740
128MATK0.36261687
129MAPK10.36261049
130DYRK1B0.36209030
131PAK10.35173113
132CSNK2A10.34914419
133CSNK1G30.34562341
134MAP3K30.34455552
135YES10.33613082
136FER0.32657826
137AKT10.32492613
138PAK20.32376761
139CASK0.32047279
140PRKDC0.31791465
141TYRO30.31784475
142RPS6KL10.31537782
143RPS6KC10.31537782
144BRAF0.30963988
145INSRR0.30605093
146PRKD30.29280942

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.15508598
2Mismatch repair_Homo sapiens_hsa034303.99476610
3One carbon pool by folate_Homo sapiens_hsa006703.50901599
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42097635
5RNA transport_Homo sapiens_hsa030133.18665040
6Spliceosome_Homo sapiens_hsa030402.91059143
7Base excision repair_Homo sapiens_hsa034102.80841994
8Cell cycle_Homo sapiens_hsa041102.77165872
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55875896
10Nucleotide excision repair_Homo sapiens_hsa034202.39318726
11Homologous recombination_Homo sapiens_hsa034402.33188133
12Non-homologous end-joining_Homo sapiens_hsa034502.12171645
13mRNA surveillance pathway_Homo sapiens_hsa030152.03527187
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01329536
15Fanconi anemia pathway_Homo sapiens_hsa034602.00889178
16Protein export_Homo sapiens_hsa030601.90582364
17* RNA polymerase_Homo sapiens_hsa030201.83232215
18Propanoate metabolism_Homo sapiens_hsa006401.81628629
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72786057
20RNA degradation_Homo sapiens_hsa030181.64856456
21* Pyrimidine metabolism_Homo sapiens_hsa002401.56269471
22Basal transcription factors_Homo sapiens_hsa030221.55928925
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53085657
24p53 signaling pathway_Homo sapiens_hsa041151.47220782
25Systemic lupus erythematosus_Homo sapiens_hsa053221.44739567
26Selenocompound metabolism_Homo sapiens_hsa004501.43495262
27Pyruvate metabolism_Homo sapiens_hsa006201.42603975
28Viral carcinogenesis_Homo sapiens_hsa052031.42487103
29Antigen processing and presentation_Homo sapiens_hsa046121.40346987
30Ribosome_Homo sapiens_hsa030101.38740776
31Steroid biosynthesis_Homo sapiens_hsa001001.36090590
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23108475
33* Epstein-Barr virus infection_Homo sapiens_hsa051691.22672602
34Proteasome_Homo sapiens_hsa030501.22657745
35Lysine degradation_Homo sapiens_hsa003101.21733272
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21193690
37Herpes simplex infection_Homo sapiens_hsa051681.16428929
38MicroRNAs in cancer_Homo sapiens_hsa052061.06081148
39Caffeine metabolism_Homo sapiens_hsa002321.05465270
40Butanoate metabolism_Homo sapiens_hsa006501.04153418
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01033267
42Biosynthesis of amino acids_Homo sapiens_hsa012300.98884667
43HTLV-I infection_Homo sapiens_hsa051660.98454846
44Fatty acid elongation_Homo sapiens_hsa000620.98194808
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96090042
46Chronic myeloid leukemia_Homo sapiens_hsa052200.93565381
47mTOR signaling pathway_Homo sapiens_hsa041500.91857091
48Primary immunodeficiency_Homo sapiens_hsa053400.91044141
49Huntingtons disease_Homo sapiens_hsa050160.90828292
50Parkinsons disease_Homo sapiens_hsa050120.90742583
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86334547
52Fatty acid metabolism_Homo sapiens_hsa012120.86301055
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.86140492
54Small cell lung cancer_Homo sapiens_hsa052220.85228776
55Oxidative phosphorylation_Homo sapiens_hsa001900.85210904
56Vitamin B6 metabolism_Homo sapiens_hsa007500.84555404
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83392539
58Thyroid cancer_Homo sapiens_hsa052160.82998530
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.82748612
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81991365
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.81409921
62Notch signaling pathway_Homo sapiens_hsa043300.79336782
63Colorectal cancer_Homo sapiens_hsa052100.78815959
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75405334
65Oocyte meiosis_Homo sapiens_hsa041140.75015403
66Adherens junction_Homo sapiens_hsa045200.74355102
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72576540
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.71346980
69Apoptosis_Homo sapiens_hsa042100.68679212
70Legionellosis_Homo sapiens_hsa051340.68091801
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68000796
72Acute myeloid leukemia_Homo sapiens_hsa052210.66446156
73B cell receptor signaling pathway_Homo sapiens_hsa046620.66243865
74Measles_Homo sapiens_hsa051620.66169800
75Pentose phosphate pathway_Homo sapiens_hsa000300.65655459
76Viral myocarditis_Homo sapiens_hsa054160.64598084
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64491146
78Non-small cell lung cancer_Homo sapiens_hsa052230.61429900
79Hepatitis B_Homo sapiens_hsa051610.59932414
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59729204
81TGF-beta signaling pathway_Homo sapiens_hsa043500.58750545
82* Purine metabolism_Homo sapiens_hsa002300.58092529
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.55761479
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55688774
85* Metabolic pathways_Homo sapiens_hsa011000.54630792
86Hippo signaling pathway_Homo sapiens_hsa043900.53855175
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52380118
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.52349064
89Folate biosynthesis_Homo sapiens_hsa007900.52007409
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49392986
91Pancreatic cancer_Homo sapiens_hsa052120.49203054
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48816517
93Arginine and proline metabolism_Homo sapiens_hsa003300.47230595
94N-Glycan biosynthesis_Homo sapiens_hsa005100.46694329
95Sulfur relay system_Homo sapiens_hsa041220.46477715
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46144366
97Carbon metabolism_Homo sapiens_hsa012000.45837768
98Sulfur metabolism_Homo sapiens_hsa009200.44928076
99T cell receptor signaling pathway_Homo sapiens_hsa046600.44562190
100Influenza A_Homo sapiens_hsa051640.43533899
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43386298
102Bladder cancer_Homo sapiens_hsa052190.42553199
103Circadian rhythm_Homo sapiens_hsa047100.41941066
104Alzheimers disease_Homo sapiens_hsa050100.41702520
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41392172
106Fatty acid biosynthesis_Homo sapiens_hsa000610.40641207
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40525209
108Prostate cancer_Homo sapiens_hsa052150.40205377
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39939482
110Proteoglycans in cancer_Homo sapiens_hsa052050.39658569
111Fatty acid degradation_Homo sapiens_hsa000710.38756774
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38740174
113Endometrial cancer_Homo sapiens_hsa052130.37562438
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37348980
115Alcoholism_Homo sapiens_hsa050340.36974114
116FoxO signaling pathway_Homo sapiens_hsa040680.35412653
117Pathways in cancer_Homo sapiens_hsa052000.35281109
118* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33550841
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32231724
120Arginine biosynthesis_Homo sapiens_hsa002200.31775902
121beta-Alanine metabolism_Homo sapiens_hsa004100.31602313
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.31527652
123Shigellosis_Homo sapiens_hsa051310.29137043
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28715341
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28471733
126Basal cell carcinoma_Homo sapiens_hsa052170.27703859
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27615482
128Tight junction_Homo sapiens_hsa045300.27346864
129HIF-1 signaling pathway_Homo sapiens_hsa040660.26856105
130Insulin resistance_Homo sapiens_hsa049310.26402669
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26306067
132Hematopoietic cell lineage_Homo sapiens_hsa046400.26031609
133AMPK signaling pathway_Homo sapiens_hsa041520.25954756
134Peroxisome_Homo sapiens_hsa041460.25675969
135Vibrio cholerae infection_Homo sapiens_hsa051100.24399032
136Wnt signaling pathway_Homo sapiens_hsa043100.24192507
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.23307623
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21362743
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21313762
140Glutathione metabolism_Homo sapiens_hsa004800.19529055
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.16264464
142Tryptophan metabolism_Homo sapiens_hsa003800.11648059

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