POLR3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.32786079
2cullin deneddylation (GO:0010388)3.96811463
3protein deneddylation (GO:0000338)3.90041791
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.64139414
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64139414
6rRNA modification (GO:0000154)3.58832970
7pseudouridine synthesis (GO:0001522)3.54839370
8regulation of cellular amino acid metabolic process (GO:0006521)3.52159770
9antigen processing and presentation of endogenous antigen (GO:0019883)3.51237800
10DNA catabolic process, exonucleolytic (GO:0000738)3.46000522
11DNA strand elongation involved in DNA replication (GO:0006271)3.42133754
12somatic hypermutation of immunoglobulin genes (GO:0016446)3.36162722
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36162722
14formation of translation preinitiation complex (GO:0001731)3.34954843
15natural killer cell mediated cytotoxicity (GO:0042267)3.33527803
16natural killer cell mediated immunity (GO:0002228)3.33527803
17DNA strand elongation (GO:0022616)3.31431734
18mannosylation (GO:0097502)3.30902293
19telomere maintenance via semi-conservative replication (GO:0032201)3.27231972
20maturation of SSU-rRNA (GO:0030490)3.22013386
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21472538
22DNA deamination (GO:0045006)3.20195994
23RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17429573
24positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13397480
25maturation of 5.8S rRNA (GO:0000460)3.13394391
26regulation of helicase activity (GO:0051095)3.09398015
27positive regulation of gamma-delta T cell activation (GO:0046645)3.07678798
28DNA double-strand break processing (GO:0000729)3.07536571
29positive regulation of ligase activity (GO:0051351)3.06467243
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05342132
31NIK/NF-kappaB signaling (GO:0038061)3.05187590
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.05148085
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.05148085
34isotype switching (GO:0045190)3.05148085
35viral transcription (GO:0019083)3.01460989
36establishment of integrated proviral latency (GO:0075713)2.97716556
37telomere maintenance via recombination (GO:0000722)2.97711317
38regulation of mitochondrial translation (GO:0070129)2.96082858
39respiratory chain complex IV assembly (GO:0008535)2.95022965
40peptidyl-histidine modification (GO:0018202)2.94837297
41folic acid-containing compound biosynthetic process (GO:0009396)2.94520485
42translational termination (GO:0006415)2.93525829
43regulation of RIG-I signaling pathway (GO:0039535)2.92409997
44protein complex biogenesis (GO:0070271)2.91696849
45DNA replication initiation (GO:0006270)2.90752094
46ribosomal small subunit biogenesis (GO:0042274)2.89872530
47GMP metabolic process (GO:0046037)2.89856588
48DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.89615483
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88533042
50rRNA methylation (GO:0031167)2.88078744
51protein targeting to mitochondrion (GO:0006626)2.87057706
52deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.84586175
53transcription-coupled nucleotide-excision repair (GO:0006283)2.84447219
54mitochondrial respiratory chain complex assembly (GO:0033108)2.83109289
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82787067
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82787067
57* transcription elongation from RNA polymerase III promoter (GO:0006385)2.82597160
58* termination of RNA polymerase III transcription (GO:0006386)2.82597160
59CENP-A containing nucleosome assembly (GO:0034080)2.82487752
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82327543
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.82327543
62NADH dehydrogenase complex assembly (GO:0010257)2.82327543
63regulation of mitotic spindle checkpoint (GO:1903504)2.81124579
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81124579
65protein localization to kinetochore (GO:0034501)2.81029154
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80909561
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80568568
68nucleobase biosynthetic process (GO:0046112)2.80371848
69translational elongation (GO:0006414)2.77704023
70regulation of ubiquitin-protein transferase activity (GO:0051438)2.75326474
71tRNA aminoacylation for protein translation (GO:0006418)2.75265376
72purine nucleobase biosynthetic process (GO:0009113)2.73289268
73establishment of viral latency (GO:0019043)2.73187599
74somatic diversification of immunoglobulins (GO:0016445)2.72567712
75histone H2A acetylation (GO:0043968)2.72407161
76chromatin remodeling at centromere (GO:0031055)2.72405367
77positive regulation of cell cycle arrest (GO:0071158)2.71831072
78regulation of ligase activity (GO:0051340)2.71211553
79nuclear pore complex assembly (GO:0051292)2.71098137
80ribosome biogenesis (GO:0042254)2.70787590
81replication fork processing (GO:0031297)2.70119218
82cytochrome complex assembly (GO:0017004)2.70074514
83amino acid activation (GO:0043038)2.69713245
84tRNA aminoacylation (GO:0043039)2.69713245
85IMP biosynthetic process (GO:0006188)2.69185907
86mitochondrial RNA metabolic process (GO:0000959)2.68416682
87Arp2/3 complex-mediated actin nucleation (GO:0034314)2.68274577
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67463952
89ribonucleoprotein complex biogenesis (GO:0022613)2.67330184
90translational initiation (GO:0006413)2.66722772
91mitotic nuclear envelope disassembly (GO:0007077)2.66467441
92mitotic recombination (GO:0006312)2.66295802
93purine nucleotide salvage (GO:0032261)2.65523375
94synapsis (GO:0007129)2.65004670
95negative regulation of protein ubiquitination (GO:0031397)2.64412880
96somatic recombination of immunoglobulin gene segments (GO:0016447)2.62855210
97activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.62267989
98cell cycle G1/S phase transition (GO:0044843)2.61631469
99G1/S transition of mitotic cell cycle (GO:0000082)2.61631469
100B cell mediated immunity (GO:0019724)2.61228141
101non-recombinational repair (GO:0000726)2.60396947
102telomere maintenance via telomere lengthening (GO:0010833)2.59450016
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58875331
104protein localization to chromosome, centromeric region (GO:0071459)2.58414699
105antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58062425
106ribosomal large subunit biogenesis (GO:0042273)2.57663092
107mitotic metaphase plate congression (GO:0007080)2.57300739
108DNA unwinding involved in DNA replication (GO:0006268)2.55806104
109sequestering of actin monomers (GO:0042989)2.55139629
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.54950611
111DNA replication checkpoint (GO:0000076)2.54202855
112SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53801515
113nucleotide-excision repair, DNA gap filling (GO:0006297)2.53711235
114positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53375284
115immunoglobulin mediated immune response (GO:0016064)2.52462886
116regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.52141858
117nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50914566
118cellular response to interferon-beta (GO:0035458)2.48172650
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47401504
120type I interferon signaling pathway (GO:0060337)2.44389170
121cellular response to type I interferon (GO:0071357)2.44389170
122response to type I interferon (GO:0034340)2.42944191
123protein targeting to ER (GO:0045047)2.42260587
124cotranslational protein targeting to membrane (GO:0006613)2.42002100
125regulation of type I interferon-mediated signaling pathway (GO:0060338)2.41389833
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41339905
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.39688118
128regulation of B cell differentiation (GO:0045577)2.39183635
129positive regulation of B cell differentiation (GO:0045579)2.39114212
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.39000330
131positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.38821843
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38752533
133nuclear envelope disassembly (GO:0051081)2.37639535
134membrane disassembly (GO:0030397)2.37639535
135T cell apoptotic process (GO:0070231)2.36509954
136signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.36089564
137intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.36089564
138defense response to protozoan (GO:0042832)2.34640335
139signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.34481168
140signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.34481168
141signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.34481168
142neutrophil activation involved in immune response (GO:0002283)2.34365533
143regulation of necroptotic process (GO:0060544)2.33790325
144viral life cycle (GO:0019058)2.33598098
145IMP metabolic process (GO:0046040)2.30467775
146regulation of gamma-delta T cell differentiation (GO:0045586)2.30451558
147signal transduction involved in DNA damage checkpoint (GO:0072422)2.29689227
148signal transduction involved in DNA integrity checkpoint (GO:0072401)2.29689227
149regulation of response to interferon-gamma (GO:0060330)2.29183964
150proteasome assembly (GO:0043248)2.28907506
151cellular protein complex disassembly (GO:0043624)2.28803093
152signal transduction involved in cell cycle checkpoint (GO:0072395)2.28162069
153ribosome assembly (GO:0042255)2.28033218
154protein localization to endoplasmic reticulum (GO:0070972)2.27693404
155regulation of translation in response to stress (GO:0043555)2.26634756
156rRNA processing (GO:0006364)2.25955566
157establishment of protein localization to endoplasmic reticulum (GO:0072599)2.25789122
158negative regulation of ligase activity (GO:0051352)2.25404351
159negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.25404351
160response to interferon-beta (GO:0035456)2.25091463
161rRNA metabolic process (GO:0016072)2.21598321
162telomere organization (GO:0032200)2.21548496
163metaphase plate congression (GO:0051310)2.21261079
164establishment of chromosome localization (GO:0051303)2.21214268
165telomere maintenance (GO:0000723)2.21086342
166leukocyte aggregation (GO:0070486)2.20888910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.80932319
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25266647
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12719161
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.96040709
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.87937989
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.77893325
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50179876
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44440791
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.43903257
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.41269492
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.40038041
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31769026
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29654481
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26118849
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21845230
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14293489
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12889027
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.10918317
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10655813
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.06518510
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06321515
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00965221
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99122888
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99011829
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98135442
26MYC_22102868_ChIP-Seq_BL_Human1.97353813
27VDR_23849224_ChIP-Seq_CD4+_Human1.96848334
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84783296
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83294330
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82664617
31XRN2_22483619_ChIP-Seq_HELA_Human1.81685465
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81448064
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73833010
34FOXP3_21729870_ChIP-Seq_TREG_Human1.72834402
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72015883
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70748145
37* SPI1_23547873_ChIP-Seq_NB4_Human1.70573205
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68632290
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68101022
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66508252
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60013690
42DCP1A_22483619_ChIP-Seq_HELA_Human1.59872299
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59846866
44CIITA_25753668_ChIP-Seq_RAJI_Human1.59399531
45VDR_21846776_ChIP-Seq_THP-1_Human1.56853246
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55838711
47GABP_19822575_ChIP-Seq_HepG2_Human1.53277684
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52428417
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51455351
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49462854
51MYC_18940864_ChIP-ChIP_HL60_Human1.47596512
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46374114
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.45624551
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44729522
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43583489
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42243790
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41372599
58MAF_26560356_Chip-Seq_TH1_Human1.40413862
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38642443
60MYB_26560356_Chip-Seq_TH2_Human1.37606186
61ZNF274_21170338_ChIP-Seq_K562_Hela1.37512761
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.36817571
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33075812
64MYB_26560356_Chip-Seq_TH1_Human1.32674057
65ELK1_19687146_ChIP-ChIP_HELA_Human1.31987428
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.29987200
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29754151
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29675301
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28695614
70TTF2_22483619_ChIP-Seq_HELA_Human1.27396143
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.25549528
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25525653
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.25247832
74KDM5A_27292631_Chip-Seq_BREAST_Human1.23911862
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23773806
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.22283102
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22053644
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20484129
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20083324
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.19983489
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.19199721
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18121052
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17977228
84UTX_26944678_Chip-Seq_JUKART_Human1.17452042
85* TFEB_21752829_ChIP-Seq_HELA_Human1.16396597
86SCL_19346495_ChIP-Seq_HPC-7_Human1.16124993
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15384698
88AR_21909140_ChIP-Seq_LNCAP_Human1.13308761
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13146616
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12301327
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10848417
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09299658
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08443328
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07826310
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07024984
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06884252
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.06413994
98GATA1_22025678_ChIP-Seq_K562_Human1.06358044
99MAF_26560356_Chip-Seq_TH2_Human1.05352538
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04694736
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04570725
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02947810
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02454697
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01657582
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01162041
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00309432
107VDR_24763502_ChIP-Seq_THP-1_Human0.97492359
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96411456
109KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96331534
110IRF1_19129219_ChIP-ChIP_H3396_Human0.95728983
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95305940
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94361928
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93810456
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93697788
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92501422
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91481021
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91082423
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89510962
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87223272
120GATA3_26560356_Chip-Seq_TH2_Human0.86860292
121IGF1R_20145208_ChIP-Seq_DFB_Human0.85955742
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84142436
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82545707
124CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74134279
125FLI1_27457419_Chip-Seq_LIVER_Mouse0.73986651
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72012916
127EGR1_23403033_ChIP-Seq_LIVER_Mouse0.71963293
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70389587
129VDR_22108803_ChIP-Seq_LS180_Human0.68446992
130EWS_26573619_Chip-Seq_HEK293_Human0.68211057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.57701770
2MP0003693_abnormal_embryo_hatching3.42772916
3MP0001835_abnormal_antigen_presentation3.34706523
4MP0000685_abnormal_immune_system2.74354060
5MP0009785_altered_susceptibility_to2.60536931
6MP0003111_abnormal_nucleus_morphology2.53805225
7MP0002396_abnormal_hematopoietic_system2.53303127
8MP0003077_abnormal_cell_cycle2.44655914
9MP0010094_abnormal_chromosome_stability2.44070400
10MP0003763_abnormal_thymus_physiology2.41860627
11MP0005671_abnormal_response_to2.36268463
12MP0004957_abnormal_blastocyst_morpholog2.33162442
13MP0001800_abnormal_humoral_immune2.27824893
14MP0003436_decreased_susceptibility_to2.24583990
15MP0009333_abnormal_splenocyte_physiolog2.22306235
16MP0005387_immune_system_phenotype2.18112058
17MP0001790_abnormal_immune_system2.18112058
18MP0008057_abnormal_DNA_replication2.13483322
19MP0002452_abnormal_antigen_presenting2.11781503
20MP0002398_abnormal_bone_marrow2.11326300
21MP0005000_abnormal_immune_tolerance2.09380513
22MP0008058_abnormal_DNA_repair2.06732082
23MP0005025_abnormal_response_to2.03896642
24MP0001819_abnormal_immune_cell2.01518356
25MP0002420_abnormal_adaptive_immunity2.01208938
26MP0005397_hematopoietic_system_phenotyp2.01145756
27MP0001545_abnormal_hematopoietic_system2.01145756
28MP0002723_abnormal_immune_serum1.99765534
29MP0004147_increased_porphyrin_level1.96596808
30MP0008007_abnormal_cellular_replicative1.96388840
31MP0006036_abnormal_mitochondrial_physio1.95829574
32MP0002148_abnormal_hypersensitivity_rea1.94050422
33MP0006035_abnormal_mitochondrial_morpho1.88644706
34MP0000490_abnormal_crypts_of1.86972103
35MP0010352_gastrointestinal_tract_polyps1.83587904
36MP0000716_abnormal_immune_system1.82086352
37MP0003950_abnormal_plasma_membrane1.80928411
38MP0000689_abnormal_spleen_morphology1.79222828
39MP0002722_abnormal_immune_system1.78488551
40MP0004808_abnormal_hematopoietic_stem1.78275229
41MP0003718_maternal_effect1.77921966
42MP0002419_abnormal_innate_immunity1.75817770
43MP0005408_hypopigmentation1.74066123
44MP0000858_altered_metastatic_potential1.69479457
45MP0002429_abnormal_blood_cell1.68392551
46MP0002166_altered_tumor_susceptibility1.68377006
47MP0001853_heart_inflammation1.67229947
48MP0000358_abnormal_cell_content/1.65950760
49MP0010155_abnormal_intestine_physiology1.65787042
50MP0002405_respiratory_system_inflammati1.61211765
51MP0005171_absent_coat_pigmentation1.55430710
52MP0000703_abnormal_thymus_morphology1.53321771
53MP0010307_abnormal_tumor_latency1.53240376
54MP0001764_abnormal_homeostasis1.49215851
55MP0002006_tumorigenesis1.44722128
56MP0006082_CNS_inflammation1.40139904
57MP0001873_stomach_inflammation1.39359909
58MP0002019_abnormal_tumor_incidence1.37514963
59MP0005464_abnormal_platelet_physiology1.37480654
60MP0001845_abnormal_inflammatory_respons1.36250402
61MP0004947_skin_inflammation1.34625041
62MP0009278_abnormal_bone_marrow1.34208283
63MP0002163_abnormal_gland_morphology1.28627299
64MP0003724_increased_susceptibility_to1.27374825
65MP0003303_peritoneal_inflammation1.26458807
66MP0000350_abnormal_cell_proliferation1.25423800
67MP0001730_embryonic_growth_arrest1.23119701
68MP0002102_abnormal_ear_morphology1.22650097
69MP0006072_abnormal_retinal_apoptosis1.22000233
70MP0008995_early_reproductive_senescence1.21500061
71MP0000313_abnormal_cell_death1.20811011
72MP0003186_abnormal_redox_activity1.19559830
73MP0008469_abnormal_protein_level1.18206513
74MP0003866_abnormal_defecation1.17566237
75MP0001929_abnormal_gametogenesis1.16998159
76MP0005310_abnormal_salivary_gland1.16059982
77MP0003448_altered_tumor_morphology1.08355284
78MP0001119_abnormal_female_reproductive1.06074617
79MP0002132_abnormal_respiratory_system1.02062499
80MP0008932_abnormal_embryonic_tissue1.01703369
81MP0002138_abnormal_hepatobiliary_system0.99820600
82MP0009697_abnormal_copulation0.99508653
83MP0002210_abnormal_sex_determination0.98809902
84MP0005076_abnormal_cell_differentiation0.98440663
85MP0008877_abnormal_DNA_methylation0.96040894
86MP0005410_abnormal_fertilization0.95206962
87MP0003806_abnormal_nucleotide_metabolis0.90784186
88MP0003786_premature_aging0.90014851
89MP0000015_abnormal_ear_pigmentation0.89718784
90MP0003656_abnormal_erythrocyte_physiolo0.89430513
91MP0005084_abnormal_gallbladder_morpholo0.89269328
92MP0000653_abnormal_sex_gland0.88016737
93MP0008872_abnormal_physiological_respon0.87473287
94MP0001919_abnormal_reproductive_system0.87380541
95MP0009765_abnormal_xenobiotic_induced0.86939196
96MP0002080_prenatal_lethality0.85541688
97MP0005174_abnormal_tail_pigmentation0.84331739
98MP0003984_embryonic_growth_retardation0.83480472
99MP0001533_abnormal_skeleton_physiology0.83109405
100MP0001672_abnormal_embryogenesis/_devel0.81921706
101MP0005380_embryogenesis_phenotype0.81921706
102MP0001529_abnormal_vocalization0.81610468
103MP0006054_spinal_hemorrhage0.81355660
104MP0002088_abnormal_embryonic_growth/wei0.80681067
105MP0001145_abnormal_male_reproductive0.80550158
106MP0005451_abnormal_body_composition0.80500545
107MP0003567_abnormal_fetal_cardiomyocyte0.79933242
108MP0002095_abnormal_skin_pigmentation0.79643155
109MP0003646_muscle_fatigue0.79496589
110MP0009840_abnormal_foam_cell0.78213026
111MP0000613_abnormal_salivary_gland0.77812547
112MP0001697_abnormal_embryo_size0.76722314
113MP0000465_gastrointestinal_hemorrhage0.75395113
114MP0003300_gastrointestinal_ulcer0.74157800
115MP0005083_abnormal_biliary_tract0.73688751
116MP0000371_diluted_coat_color0.72456006
117MP0008873_increased_physiological_sensi0.72240535
118MP0005253_abnormal_eye_physiology0.72108919
119MP0000598_abnormal_liver_morphology0.71980131
120MP0005023_abnormal_wound_healing0.71611186
121MP0000343_altered_response_to0.71071771
122MP0002877_abnormal_melanocyte_morpholog0.70145247
123MP0009764_decreased_sensitivity_to0.69907100
124MP0002086_abnormal_extraembryonic_tissu0.69836051
125MP0009763_increased_sensitivity_to0.67973598
126MP0005384_cellular_phenotype0.67487191
127MP0002234_abnormal_pharynx_morphology0.66745028
128MP0000427_abnormal_hair_cycle0.66543696
129MP0001191_abnormal_skin_condition0.65259547
130MP0002933_joint_inflammation0.64866407
131MP0005075_abnormal_melanosome_morpholog0.64621035
132MP0005389_reproductive_system_phenotype0.63561249
133MP0000477_abnormal_intestine_morphology0.63466695
134MP0005058_abnormal_lysosome_morphology0.63032035
135MP0003943_abnormal_hepatobiliary_system0.61715263

Predicted human phenotypes

RankGene SetZ-score
1Abnormal protein glycosylation (HP:0012346)3.89341040
2Abnormal glycosylation (HP:0012345)3.89341040
3Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.89341040
4Abnormal protein N-linked glycosylation (HP:0012347)3.89341040
5Thrombocytosis (HP:0001894)3.84118366
6Eczematoid dermatitis (HP:0000976)3.61255324
7Recurrent abscess formation (HP:0002722)3.59107218
8IgM deficiency (HP:0002850)3.55704303
9Hepatocellular necrosis (HP:0001404)3.50859158
10Acute necrotizing encephalopathy (HP:0006965)3.50636986
11Abnormal mitochondria in muscle tissue (HP:0008316)3.46308438
12Increased CSF lactate (HP:0002490)3.45292600
13Reticulocytopenia (HP:0001896)3.41368499
14Mitochondrial inheritance (HP:0001427)3.36710171
15Recurrent fungal infections (HP:0002841)3.33020811
16Elevated erythrocyte sedimentation rate (HP:0003565)3.31419384
17Recurrent viral infections (HP:0004429)3.29027415
18Recurrent bacterial skin infections (HP:0005406)3.27799540
19Chronic otitis media (HP:0000389)3.25740999
20Autoimmune thrombocytopenia (HP:0001973)3.21157690
21Acute encephalopathy (HP:0006846)3.19702489
22Myositis (HP:0100614)3.15246795
23Recurrent bronchitis (HP:0002837)3.12633473
24Hepatic necrosis (HP:0002605)3.06996759
25Increased serum lactate (HP:0002151)3.06488228
26Abnormality of T cell physiology (HP:0011840)3.03539693
27Pustule (HP:0200039)3.01475629
28Petechiae (HP:0000967)2.99872291
29Abnormality of T cells (HP:0002843)2.98539109
30Microvesicular hepatic steatosis (HP:0001414)2.95336969
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89423649
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89423649
33Abnormality of cells of the erythroid lineage (HP:0012130)2.88917484
34Ependymoma (HP:0002888)2.85955492
35Abnormal number of erythroid precursors (HP:0012131)2.75497851
36Progressive macrocephaly (HP:0004481)2.73814547
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.70703842
38Cerebral edema (HP:0002181)2.66938337
39Cutaneous melanoma (HP:0012056)2.66225074
40Increased hepatocellular lipid droplets (HP:0006565)2.65327315
41Lactic acidosis (HP:0003128)2.65198636
42Abnormality of T cell number (HP:0011839)2.64994688
43Combined immunodeficiency (HP:0005387)2.63820886
44Birth length less than 3rd percentile (HP:0003561)2.62849941
45Colon cancer (HP:0003003)2.61545006
46Aplastic anemia (HP:0001915)2.57584390
47Increased IgM level (HP:0003496)2.55299737
48Nasal polyposis (HP:0100582)2.55103086
49Chromsome breakage (HP:0040012)2.54781497
50Severe combined immunodeficiency (HP:0004430)2.53554740
51IgG deficiency (HP:0004315)2.52421082
52Vasculitis (HP:0002633)2.52071264
53Agnosia (HP:0010524)2.50138769
54T lymphocytopenia (HP:0005403)2.47017776
55Retrobulbar optic neuritis (HP:0100654)2.45611504
56Optic neuritis (HP:0100653)2.45611504
57Myelodysplasia (HP:0002863)2.45250804
58Granulocytopenia (HP:0001913)2.45221069
59Mediastinal lymphadenopathy (HP:0100721)2.45009983
60Cellulitis (HP:0100658)2.44713181
61Lipid accumulation in hepatocytes (HP:0006561)2.44229493
62Cerebral hypomyelination (HP:0006808)2.43097734
63Orchitis (HP:0100796)2.42478314
64Renal Fanconi syndrome (HP:0001994)2.41102968
65Panhypogammaglobulinemia (HP:0003139)2.40804248
66Spontaneous hematomas (HP:0007420)2.40567645
67Amaurosis fugax (HP:0100576)2.39623312
68Meckel diverticulum (HP:0002245)2.38378802
69Abnormality of the nasal mucosa (HP:0000433)2.38200396
70Pancytopenia (HP:0001876)2.38083401
71Lymphoma (HP:0002665)2.36479415
72Encephalitis (HP:0002383)2.36274098
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.36018926
74Meningitis (HP:0001287)2.33213403
75Fatigue (HP:0012378)2.32723010
76Abnormality of the anterior horn cell (HP:0006802)2.32387279
77Degeneration of anterior horn cells (HP:0002398)2.32387279
78Reduced antithrombin III activity (HP:0001976)2.31913464
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30173509
80Chronic obstructive pulmonary disease (HP:0006510)2.29567907
81Obstructive lung disease (HP:0006536)2.29567907
82Increased intramyocellular lipid droplets (HP:0012240)2.28085356
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.27725068
84Abnormality of alanine metabolism (HP:0010916)2.27157274
85Hyperalaninemia (HP:0003348)2.27157274
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27157274
87Abnormality of the ileum (HP:0001549)2.26857922
88Abnormality of macrophages (HP:0004311)2.25954738
89Eosinophilia (HP:0001880)2.25794605
90Recurrent skin infections (HP:0001581)2.25730198
91Prostate neoplasm (HP:0100787)2.23392998
92Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23115551
93Pallor (HP:0000980)2.22833923
94Oral leukoplakia (HP:0002745)2.22688647
95Leukocytosis (HP:0001974)2.21614845
96Recurrent cutaneous fungal infections (HP:0011370)2.20775473
97Chronic mucocutaneous candidiasis (HP:0002728)2.20775473
98Lymphopenia (HP:0001888)2.19519177
99Abnormality of eosinophils (HP:0001879)2.18828865
100B lymphocytopenia (HP:0010976)2.18694505
101Recurrent gram-negative bacterial infections (HP:0005420)2.17949361
102Agammaglobulinemia (HP:0004432)2.17892237
103Bone marrow hypocellularity (HP:0005528)2.17332544
104Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17247588
1053-Methylglutaconic aciduria (HP:0003535)2.17124734
106CNS demyelination (HP:0007305)2.16760191
107Cellular immunodeficiency (HP:0005374)2.16440587
108Abnormality of B cell number (HP:0010975)2.14118151
109Gastrointestinal infarctions (HP:0005244)2.14046639
110Optic disc pallor (HP:0000543)2.12054989
111Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10565703
112Exercise intolerance (HP:0003546)2.10350154
113IgA deficiency (HP:0002720)2.10243165
114Stomatitis (HP:0010280)2.10016350
115Respiratory failure (HP:0002878)2.08716308
116Basal ganglia calcification (HP:0002135)2.07980229
117Poor head control (HP:0002421)2.07764147
118Abnormality of the prostate (HP:0008775)2.07733499
119Basal cell carcinoma (HP:0002671)2.06788981
120Type I transferrin isoform profile (HP:0003642)2.05726254
121Abnormality of the preputium (HP:0100587)2.05255495
122Abnormality of the fingertips (HP:0001211)2.03844796
123Gastrointestinal inflammation (HP:0004386)2.03826857
124Abnormality of lateral ventricle (HP:0030047)2.03264669
125Hypochromic anemia (HP:0001931)2.03084403
126Albinism (HP:0001022)2.02432967
127Posterior subcapsular cataract (HP:0007787)2.02331266
128Progressive inability to walk (HP:0002505)2.01078308
129Poikiloderma (HP:0001029)2.00626500
130Leukopenia (HP:0001882)1.99458373
131Clubbing of toes (HP:0100760)1.98582498
132Premature ovarian failure (HP:0008209)1.98216425
133Hypergammaglobulinemia (HP:0010702)1.97865235
134Periodontitis (HP:0000704)1.97313645
135Neutropenia (HP:0001875)1.96574325
136Duodenal stenosis (HP:0100867)1.94968549
137Small intestinal stenosis (HP:0012848)1.94968549
138Attenuation of retinal blood vessels (HP:0007843)1.94411948
139Methylmalonic aciduria (HP:0012120)1.94223965
140Microretrognathia (HP:0000308)1.93032276
141Epistaxis (HP:0000421)1.92907842
142Abnormality of methionine metabolism (HP:0010901)1.92086331
143Breast hypoplasia (HP:0003187)1.92056717
144Increased IgE level (HP:0003212)1.90191028
145Rough bone trabeculation (HP:0100670)1.90115314
146Abnormality of chromosome stability (HP:0003220)1.89662557
147Osteomyelitis (HP:0002754)1.89573015
148Abnormality of the astrocytes (HP:0100707)1.89157881
149Astrocytoma (HP:0009592)1.89157881
150Patellar aplasia (HP:0006443)1.88525705
151Macrocytic anemia (HP:0001972)1.88190464
152Recurrent pneumonia (HP:0006532)1.87908390
153Lethargy (HP:0001254)1.87658281
154Gingivitis (HP:0000230)1.87396577
155Methylmalonic acidemia (HP:0002912)1.86575904
156Abnormality of midbrain morphology (HP:0002418)1.85178440
157Molar tooth sign on MRI (HP:0002419)1.85178440
158Skin ulcer (HP:0200042)1.84561915
159Abnormality of reticulocytes (HP:0004312)1.84163620
160Interstitial pulmonary disease (HP:0006530)1.84136285
161Absent thumb (HP:0009777)1.83422146
162Impaired platelet aggregation (HP:0003540)1.82789363
163Abnormal platelet function (HP:0011869)1.82789363
164Urticaria (HP:0001025)1.82450014
165Constricted visual fields (HP:0001133)1.82282773
166Abnormality of the heme biosynthetic pathway (HP:0010472)1.82248575
167Secondary amenorrhea (HP:0000869)1.80406803
168Squamous cell carcinoma (HP:0002860)1.80329724
169Emotional lability (HP:0000712)1.79807605
170Pancreatic cysts (HP:0001737)1.79318307
171Premature graying of hair (HP:0002216)1.78926919
172Increased muscle lipid content (HP:0009058)1.78880316
173Hypoproteinemia (HP:0003075)1.77904283
174Respiratory difficulties (HP:0002880)1.75549986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.79614853
2MAP4K13.37500423
3BUB12.98943953
4BLK2.96888667
5NUAK12.60319095
6WEE12.53556888
7TYK22.47318450
8NME22.44024530
9MAP4K22.37551063
10PLK42.22096727
11TRIM282.19690246
12STK102.12226615
13EIF2AK12.11190593
14NEK22.09443575
15CDC72.01715859
16SIK31.99780015
17PIM21.98634919
18MAP3K141.95225109
19PDK21.92262174
20ZAP701.91264418
21TXK1.89531712
22JAK31.79724861
23TBK11.77443822
24TSSK61.65159202
25TAF11.64565052
26IRAK41.59704452
27SRPK11.56967905
28BTK1.50744141
29EEF2K1.49292801
30BMPR1B1.47554107
31RPS6KA41.46688162
32TESK21.43497734
33IKBKB1.43304690
34IKBKE1.38606314
35KIT1.38446056
36MAP3K101.32544014
37TTK1.31579561
38BRSK21.30705890
39EIF2AK31.28974500
40GRK71.27692700
41ADRBK21.24166854
42PLK31.23943929
43TAOK31.23806034
44ATR1.22987864
45LRRK21.22760386
46PIM11.21369944
47RPS6KB21.20008996
48STK41.19512771
49MAP3K81.17928573
50KDR1.17885531
51GRK61.14911835
52CDK81.10136304
53FLT31.09717553
54TESK11.07499542
55CDK41.07040568
56CDK71.06660971
57DAPK11.06049072
58TEC1.04887639
59PASK1.04373305
60ACVR1B1.03005678
61SYK1.02740102
62AURKB1.02646453
63MAP2K31.02343124
64TAOK21.02050408
65MAP3K121.02046570
66NME11.00221767
67PLK10.98162777
68CSF1R0.98134282
69JAK10.97244113
70STK160.96784833
71BCR0.96371227
72ERN10.95959883
73CSNK1G30.95624694
74ERBB30.94738024
75TGFBR20.93914118
76MAP2K60.93417195
77CHUK0.92385206
78MKNK10.91170175
79GRK10.90541243
80NEK90.88940205
81BRSK10.87871863
82PAK40.86822563
83LYN0.85825324
84MAPK110.83269095
85CDK120.82940133
86LCK0.82818068
87VRK10.82545197
88CSNK1A1L0.81664954
89MKNK20.80803593
90IRAK30.80184303
91TGFBR10.79980712
92CSNK1G10.76223970
93MST40.75835892
94MAP3K130.70140982
95NEK10.69743053
96FGFR40.69473462
97MAPKAPK30.68229571
98ERBB40.67626999
99CHEK10.66812985
100PKN20.65551066
101PBK0.64600324
102CSK0.64245339
103BCKDK0.63734452
104ITK0.62634799
105EIF2AK20.61694861
106FRK0.60899313
107HCK0.60381014
108CCNB10.60041733
109CSNK1G20.59805164
110STK240.59325549
111TIE10.57245156
112MAP3K110.55652931
113RPS6KA50.54426980
114WNK30.53520067
115MARK30.53260630
116MAPKAPK20.52208725
117CHEK20.51909569
118STK30.51220415
119MAP3K50.51182517
120ZAK0.51087604
121CDK60.50834302
122AURKA0.50786778
123NLK0.50283758
124GRK50.49362485
125MUSK0.49156493
126TNK20.48325853
127PRKCI0.47613671
128ATM0.46891032
129DYRK30.46345259
130PAK10.44509958
131CSNK2A20.43777701
132TLK10.43689313
133CSNK2A10.43511187
134SCYL20.43252478
135CLK10.42543950
136INSRR0.34909979
137CDK90.31446640
138CAMKK20.29899538
139PRKCQ0.29283050
140MATK0.28774545

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.65745969
2Mismatch repair_Homo sapiens_hsa034303.02007278
3Proteasome_Homo sapiens_hsa030502.91883293
4Ribosome_Homo sapiens_hsa030102.71701503
5Base excision repair_Homo sapiens_hsa034102.46001290
6Homologous recombination_Homo sapiens_hsa034402.36338762
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27116668
8Primary immunodeficiency_Homo sapiens_hsa053402.18482272
9* RNA polymerase_Homo sapiens_hsa030202.16517057
10* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15087561
11One carbon pool by folate_Homo sapiens_hsa006702.12377442
12Spliceosome_Homo sapiens_hsa030402.10846086
13RNA transport_Homo sapiens_hsa030131.91534144
14Antigen processing and presentation_Homo sapiens_hsa046121.90503329
15Allograft rejection_Homo sapiens_hsa053301.88024999
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.85010536
17* Pyrimidine metabolism_Homo sapiens_hsa002401.82366356
18Nucleotide excision repair_Homo sapiens_hsa034201.80893843
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.78751892
20Oxidative phosphorylation_Homo sapiens_hsa001901.77263061
21Cell cycle_Homo sapiens_hsa041101.72327292
22Measles_Homo sapiens_hsa051621.71514870
23Herpes simplex infection_Homo sapiens_hsa051681.71396569
24Fatty acid elongation_Homo sapiens_hsa000621.70579353
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69475352
26Parkinsons disease_Homo sapiens_hsa050121.65197195
27Graft-versus-host disease_Homo sapiens_hsa053321.59338666
28Leishmaniasis_Homo sapiens_hsa051401.56514229
29Non-homologous end-joining_Homo sapiens_hsa034501.55117356
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53298967
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51332487
32Legionellosis_Homo sapiens_hsa051341.48727606
33p53 signaling pathway_Homo sapiens_hsa041151.45272420
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44643589
35Propanoate metabolism_Homo sapiens_hsa006401.43213663
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35439839
37Fanconi anemia pathway_Homo sapiens_hsa034601.34728684
38Sulfur metabolism_Homo sapiens_hsa009201.31891361
39* Epstein-Barr virus infection_Homo sapiens_hsa051691.28144562
40N-Glycan biosynthesis_Homo sapiens_hsa005101.22224989
41Huntingtons disease_Homo sapiens_hsa050161.18633663
42Apoptosis_Homo sapiens_hsa042101.15680447
43Influenza A_Homo sapiens_hsa051641.10700450
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09352786
45RNA degradation_Homo sapiens_hsa030181.08255255
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08087649
47Pentose phosphate pathway_Homo sapiens_hsa000301.07978941
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07787236
49Shigellosis_Homo sapiens_hsa051311.03310789
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02757814
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00320923
52Viral myocarditis_Homo sapiens_hsa054160.97825364
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.96466723
54Hematopoietic cell lineage_Homo sapiens_hsa046400.96113505
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95763207
56Sulfur relay system_Homo sapiens_hsa041220.95411008
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92994251
58B cell receptor signaling pathway_Homo sapiens_hsa046620.92413088
59Glutathione metabolism_Homo sapiens_hsa004800.92072518
60Asthma_Homo sapiens_hsa053100.91146940
61Viral carcinogenesis_Homo sapiens_hsa052030.90049975
62Folate biosynthesis_Homo sapiens_hsa007900.88648209
63Toxoplasmosis_Homo sapiens_hsa051450.86661380
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.86218904
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.86014775
66mRNA surveillance pathway_Homo sapiens_hsa030150.85917699
67Basal transcription factors_Homo sapiens_hsa030220.85614614
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85604724
69Autoimmune thyroid disease_Homo sapiens_hsa053200.85021439
70Hepatitis B_Homo sapiens_hsa051610.84997755
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83529988
72* Purine metabolism_Homo sapiens_hsa002300.83402786
73Osteoclast differentiation_Homo sapiens_hsa043800.79878679
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78143021
75Acute myeloid leukemia_Homo sapiens_hsa052210.76205791
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.74825340
77TNF signaling pathway_Homo sapiens_hsa046680.74445922
78Alzheimers disease_Homo sapiens_hsa050100.73909324
79Peroxisome_Homo sapiens_hsa041460.71483059
80HTLV-I infection_Homo sapiens_hsa051660.70774650
81Pertussis_Homo sapiens_hsa051330.69633920
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68076971
83T cell receptor signaling pathway_Homo sapiens_hsa046600.67740398
84Pyruvate metabolism_Homo sapiens_hsa006200.66903542
85* Metabolic pathways_Homo sapiens_hsa011000.66063031
86Small cell lung cancer_Homo sapiens_hsa052220.65799748
87Type I diabetes mellitus_Homo sapiens_hsa049400.64818902
88Fructose and mannose metabolism_Homo sapiens_hsa000510.64506864
89Steroid biosynthesis_Homo sapiens_hsa001000.63881052
90Tuberculosis_Homo sapiens_hsa051520.63354001
91Fatty acid metabolism_Homo sapiens_hsa012120.59893397
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59710874
93Biosynthesis of amino acids_Homo sapiens_hsa012300.59298109
94Regulation of autophagy_Homo sapiens_hsa041400.57154861
95Selenocompound metabolism_Homo sapiens_hsa004500.56778858
96Hepatitis C_Homo sapiens_hsa051600.55997215
97Chronic myeloid leukemia_Homo sapiens_hsa052200.53434434
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53369831
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52989805
100Other glycan degradation_Homo sapiens_hsa005110.52874857
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51052158
102Galactose metabolism_Homo sapiens_hsa000520.50051567
103Rheumatoid arthritis_Homo sapiens_hsa053230.49305290
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.48631037
105Staphylococcus aureus infection_Homo sapiens_hsa051500.47798251
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46843222
107Protein export_Homo sapiens_hsa030600.45177692
108Butanoate metabolism_Homo sapiens_hsa006500.45055831
109Malaria_Homo sapiens_hsa051440.45002670
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44783712
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44156315
112Vitamin B6 metabolism_Homo sapiens_hsa007500.43734974
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43606478
114Systemic lupus erythematosus_Homo sapiens_hsa053220.42517917
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41446711
116Carbon metabolism_Homo sapiens_hsa012000.41049933
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40599847
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39215112
119Chemokine signaling pathway_Homo sapiens_hsa040620.38045218
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37734767
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37444297
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36929421
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36852137
124Tryptophan metabolism_Homo sapiens_hsa003800.36142440
125Notch signaling pathway_Homo sapiens_hsa043300.35903022
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35649241
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34535047
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34392955
129Oocyte meiosis_Homo sapiens_hsa041140.34189405
130Lysosome_Homo sapiens_hsa041420.34155532
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34072795
132HIF-1 signaling pathway_Homo sapiens_hsa040660.32684094
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31893277
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.30889952
135Phototransduction_Homo sapiens_hsa047440.30387118
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29713158
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.28750541
138Renin-angiotensin system_Homo sapiens_hsa046140.27790277

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