POLR3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.12141786
2maturation of SSU-rRNA (GO:0030490)4.85408773
3formation of translation preinitiation complex (GO:0001731)4.80581349
4ribosome biogenesis (GO:0042254)4.64610569
5DNA deamination (GO:0045006)4.43241358
6nucleobase biosynthetic process (GO:0046112)4.32740263
7folic acid-containing compound biosynthetic process (GO:0009396)4.31180472
8ribosome assembly (GO:0042255)4.22991186
9ribonucleoprotein complex biogenesis (GO:0022613)4.11164778
10proteasome assembly (GO:0043248)4.11142284
11purine nucleobase biosynthetic process (GO:0009113)4.05167615
12pore complex assembly (GO:0046931)3.92367744
13mitotic metaphase plate congression (GO:0007080)3.90812811
14spliceosomal tri-snRNP complex assembly (GO:0000244)3.84634761
15ribosomal small subunit assembly (GO:0000028)3.83754871
16rRNA processing (GO:0006364)3.79797616
17DNA unwinding involved in DNA replication (GO:0006268)3.77564364
18DNA replication initiation (GO:0006270)3.71956123
19IMP biosynthetic process (GO:0006188)3.69144657
20rRNA metabolic process (GO:0016072)3.69068322
21peptidyl-arginine omega-N-methylation (GO:0035247)3.67996976
22translational initiation (GO:0006413)3.66776220
23mitotic chromosome condensation (GO:0007076)3.66449652
24spliceosomal snRNP assembly (GO:0000387)3.65606079
25maturation of 5.8S rRNA (GO:0000460)3.65386342
26ribosomal large subunit biogenesis (GO:0042273)3.65380859
27translational termination (GO:0006415)3.61224889
28folic acid metabolic process (GO:0046655)3.61166311
29pseudouridine synthesis (GO:0001522)3.59394253
30viral transcription (GO:0019083)3.58974710
31regulation of RNA export from nucleus (GO:0046831)3.53994921
32DNA strand elongation involved in DNA replication (GO:0006271)3.52383795
33proline biosynthetic process (GO:0006561)3.51658734
34ribosomal small subunit biogenesis (GO:0042274)3.49227067
35DNA topological change (GO:0006265)3.45395993
36regulation of gene silencing by RNA (GO:0060966)3.44260885
37regulation of posttranscriptional gene silencing (GO:0060147)3.44260885
38regulation of gene silencing by miRNA (GO:0060964)3.44260885
39histone arginine methylation (GO:0034969)3.40549908
40IMP metabolic process (GO:0046040)3.39822041
41* transcription elongation from RNA polymerase III promoter (GO:0006385)3.39772615
42* termination of RNA polymerase III transcription (GO:0006386)3.39772615
43translational elongation (GO:0006414)3.37569789
44negative regulation of mRNA processing (GO:0050686)3.37220972
45protein localization to chromosome, centromeric region (GO:0071459)3.36556337
46negative regulation of RNA splicing (GO:0033119)3.33547253
47DNA strand elongation (GO:0022616)3.33206139
48DNA replication checkpoint (GO:0000076)3.32879578
49mitotic nuclear envelope disassembly (GO:0007077)3.30780702
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28115330
51negative regulation of mRNA metabolic process (GO:1903312)3.26769441
52metaphase plate congression (GO:0051310)3.22473324
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20464805
54protein targeting to ER (GO:0045047)3.19787155
55nuclear pore organization (GO:0006999)3.18586801
56cotranslational protein targeting to membrane (GO:0006613)3.18542112
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17475012
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14424149
59membrane disassembly (GO:0030397)3.12674324
60nuclear envelope disassembly (GO:0051081)3.12674324
61mitotic sister chromatid segregation (GO:0000070)3.12632518
62paraxial mesoderm development (GO:0048339)3.12338650
63DNA replication-dependent nucleosome organization (GO:0034723)3.12310442
64DNA replication-dependent nucleosome assembly (GO:0006335)3.12310442
65rRNA modification (GO:0000154)3.12151244
66mitotic sister chromatid cohesion (GO:0007064)3.10656067
67cellular component biogenesis (GO:0044085)3.08785794
68peptidyl-arginine N-methylation (GO:0035246)3.06813714
69peptidyl-arginine methylation (GO:0018216)3.06813714
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05351964
71translation (GO:0006412)3.04966770
72establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04135553
73sister chromatid segregation (GO:0000819)3.04000028
74protein localization to kinetochore (GO:0034501)3.03538805
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02628914
76DNA duplex unwinding (GO:0032508)3.02291785
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02236202
78protein-DNA complex disassembly (GO:0032986)3.00505733
79nucleosome disassembly (GO:0006337)3.00505733
80protein localization to endoplasmic reticulum (GO:0070972)3.00027144
81tRNA methylation (GO:0030488)2.99942993
82chromatin assembly (GO:0031497)2.99195641
83regulation of spindle organization (GO:0090224)2.98591512
84viral mRNA export from host cell nucleus (GO:0046784)2.98416953
85protein complex localization (GO:0031503)2.98020725
86pteridine-containing compound biosynthetic process (GO:0042559)2.96823476
87tRNA aminoacylation for protein translation (GO:0006418)2.96528141
88RNA splicing, via transesterification reactions (GO:0000375)2.95959220
89mRNA splicing, via spliceosome (GO:0000398)2.93818920
90RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.93818920
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92797137
92ncRNA processing (GO:0034470)2.92161977
937-methylguanosine mRNA capping (GO:0006370)2.92079346
94transcription from RNA polymerase I promoter (GO:0006360)2.91629801
95DNA geometric change (GO:0032392)2.90828810
96spliceosomal complex assembly (GO:0000245)2.90690229
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90370175
98negative regulation of ligase activity (GO:0051352)2.90370175
99ncRNA metabolic process (GO:0034660)2.90303830
100establishment of integrated proviral latency (GO:0075713)2.89634143
101cellular protein complex disassembly (GO:0043624)2.86160279
102tRNA aminoacylation (GO:0043039)2.84742748
103amino acid activation (GO:0043038)2.84742748
104termination of RNA polymerase I transcription (GO:0006363)2.84251743
1057-methylguanosine RNA capping (GO:0009452)2.84200492
106RNA capping (GO:0036260)2.84200492
107viral life cycle (GO:0019058)2.84111280
108regulation of translational fidelity (GO:0006450)2.83779065
109COPI coating of Golgi vesicle (GO:0048205)2.82946377
110Golgi transport vesicle coating (GO:0048200)2.82946377
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80887156
112DNA synthesis involved in DNA repair (GO:0000731)2.80402727
113protein K6-linked ubiquitination (GO:0085020)2.78980065
114histone H2A monoubiquitination (GO:0035518)2.78854645
115telomere maintenance via semi-conservative replication (GO:0032201)2.78692087
116histone H2A acetylation (GO:0043968)2.76661975
117regulation of nucleobase-containing compound transport (GO:0032239)2.76492300
118regulation of translation in response to stress (GO:0043555)2.76204561
119regulation of translational elongation (GO:0006448)2.75803580
120pre-miRNA processing (GO:0031054)2.75773043
121negative regulation of translational initiation (GO:0045947)2.75718195
122DNA replication-independent nucleosome organization (GO:0034724)2.74847856
123DNA replication-independent nucleosome assembly (GO:0006336)2.74847856
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73242535
125regulation of DNA damage checkpoint (GO:2000001)2.72912447
126peptidyl-histidine modification (GO:0018202)2.71217272
127negative regulation of cell size (GO:0045792)2.70901211
128regulation of histone H3-K9 methylation (GO:0051570)2.70849428
129protein complex disassembly (GO:0043241)2.70732645
130heterochromatin organization (GO:0070828)2.69911844
131transcription-coupled nucleotide-excision repair (GO:0006283)2.69547743
132DNA conformation change (GO:0071103)2.68299384
133macromolecular complex disassembly (GO:0032984)2.66781547
134negative regulation of histone methylation (GO:0031061)2.65701432
135mitochondrial DNA metabolic process (GO:0032042)2.64361948
136RNA stabilization (GO:0043489)2.63102372
137mRNA stabilization (GO:0048255)2.63102372
138planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61058065
139negative regulation of potassium ion transmembrane transport (GO:1901380)2.60682490
140cellular protein complex localization (GO:0034629)2.60335508
141mRNA transport (GO:0051028)2.57341082
142regulation of translational termination (GO:0006449)2.56026112
143rRNA transcription (GO:0009303)2.55930754
144negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.53930330
145chromosome condensation (GO:0030261)2.53005774
146L-serine metabolic process (GO:0006563)2.51677696
147convergent extension (GO:0060026)2.51385864
148regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50843171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.99938358
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.66115634
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91838873
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23156457
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.17223753
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.13233947
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11662417
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99880325
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98729213
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98369212
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.92677941
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71808332
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57187067
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.53626499
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53337051
16* XRN2_22483619_ChIP-Seq_HELA_Human2.47795427
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41418050
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34360659
19VDR_23849224_ChIP-Seq_CD4+_Human2.23238629
20E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15771481
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15570803
22* DCP1A_22483619_ChIP-Seq_HELA_Human2.12028317
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09601021
24* GABP_19822575_ChIP-Seq_HepG2_Human2.09234485
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04326394
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03206880
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89513207
28* TTF2_22483619_ChIP-Seq_HELA_Human1.88537186
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85315234
30FOXP3_21729870_ChIP-Seq_TREG_Human1.83598828
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82915389
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82044510
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80207488
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79427597
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76277478
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75706974
37MYC_22102868_ChIP-Seq_BL_Human1.75112061
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73617159
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72308806
40AR_21909140_ChIP-Seq_LNCAP_Human1.71527400
41CIITA_25753668_ChIP-Seq_RAJI_Human1.68076059
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64095495
43* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62792513
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.61247548
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60367257
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.59355295
47KDM5A_27292631_Chip-Seq_BREAST_Human1.57517709
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57454015
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55368071
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.52027969
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50914232
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50490236
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50371830
54TFEB_21752829_ChIP-Seq_HELA_Human1.48822788
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45541351
56ELK1_19687146_ChIP-ChIP_HELA_Human1.45096821
57* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44829712
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44825572
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44299555
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40188615
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39301999
62* NOTCH1_21737748_ChIP-Seq_TLL_Human1.39092786
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39037009
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37455881
65* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37338500
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34730247
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31696728
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.30815587
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.29067672
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27497549
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27009545
72* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24815307
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24709518
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.23913972
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22671668
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22524678
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.22462250
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20659078
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20426497
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.19490595
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19032694
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18810441
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17252743
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14701745
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13812245
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13659730
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12096740
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.10673075
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10662766
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09995625
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08837160
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06813816
93CLOCK_20551151_ChIP-Seq_293T_Human1.03576241
94ZNF263_19887448_ChIP-Seq_K562_Human1.03519918
95* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01957733
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00092557
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99628701
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98861391
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98861391
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98861391
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98781471
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98501244
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98430522
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98294612
105CHD1_26751641_Chip-Seq_LNCaP_Human0.97497213
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97350508
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96784593
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95685779
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.94996408
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.94223081
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93822374
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92684251
113VDR_21846776_ChIP-Seq_THP-1_Human0.91672095
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87598558
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85436395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.62997411
2MP0004957_abnormal_blastocyst_morpholog4.30386348
3MP0003111_abnormal_nucleus_morphology3.69649710
4MP0010094_abnormal_chromosome_stability3.40009878
5MP0003077_abnormal_cell_cycle3.34724911
6MP0003123_paternal_imprinting3.06638762
7MP0008057_abnormal_DNA_replication3.03952754
8MP0008058_abnormal_DNA_repair2.74602172
9MP0001730_embryonic_growth_arrest2.59483623
10MP0008007_abnormal_cellular_replicative2.57554382
11MP0008932_abnormal_embryonic_tissue2.53129935
12MP0003950_abnormal_plasma_membrane2.38600888
13MP0004272_abnormal_basement_membrane2.15287959
14MP0000350_abnormal_cell_proliferation2.12854102
15MP0008877_abnormal_DNA_methylation2.09607998
16MP0002254_reproductive_system_inflammat2.03476865
17MP0003283_abnormal_digestive_organ2.00008215
18MP0010352_gastrointestinal_tract_polyps1.97989043
19MP0001697_abnormal_embryo_size1.95471287
20MP0010030_abnormal_orbit_morphology1.87812854
21MP0005380_embryogenesis_phenotype1.81194205
22MP0001672_abnormal_embryogenesis/_devel1.81194205
23MP0003786_premature_aging1.74943283
24MP0004197_abnormal_fetal_growth/weight/1.73969738
25MP0003984_embryonic_growth_retardation1.73565220
26MP0002084_abnormal_developmental_patter1.73158815
27MP0002088_abnormal_embryonic_growth/wei1.70944197
28MP0000751_myopathy1.69620817
29MP0002080_prenatal_lethality1.69253440
30MP0002085_abnormal_embryonic_tissue1.67222757
31MP0004133_heterotaxia1.67009575
32MP0003121_genomic_imprinting1.66133954
33MP0003567_abnormal_fetal_cardiomyocyte1.63700305
34MP0005503_abnormal_tendon_morphology1.61598786
35MP0002249_abnormal_larynx_morphology1.58892947
36MP0003718_maternal_effect1.53422710
37MP0009697_abnormal_copulation1.48260170
38MP0006292_abnormal_olfactory_placode1.48077314
39MP0002086_abnormal_extraembryonic_tissu1.46995509
40MP0000759_abnormal_skeletal_muscle1.46600360
41MP0003119_abnormal_digestive_system1.42789178
42MP0002697_abnormal_eye_size1.41335630
43MP0009333_abnormal_splenocyte_physiolog1.39340043
44MP0000490_abnormal_crypts_of1.38979629
45MP0005451_abnormal_body_composition1.35189458
46MP0000749_muscle_degeneration1.33979584
47MP0000313_abnormal_cell_death1.33267776
48MP0002009_preneoplasia1.32127801
49MP0009379_abnormal_foot_pigmentation1.32003414
50MP0005623_abnormal_meninges_morphology1.31813244
51MP0005076_abnormal_cell_differentiation1.31192734
52MP0000537_abnormal_urethra_morphology1.31033903
53MP0004808_abnormal_hematopoietic_stem1.30599317
54MP0010368_abnormal_lymphatic_system1.27600453
55MP0004858_abnormal_nervous_system1.27381044
56MP0002396_abnormal_hematopoietic_system1.27220391
57MP0001348_abnormal_lacrimal_gland1.24523673
58MP0000750_abnormal_muscle_regeneration1.24007900
59MP0003122_maternal_imprinting1.17105713
60MP0001661_extended_life_span1.16796482
61MP0003942_abnormal_urinary_system1.16368130
62MP0005187_abnormal_penis_morphology1.14535259
63MP0002092_abnormal_eye_morphology1.13430696
64MP0000358_abnormal_cell_content/1.13230488
65MP0004087_abnormal_muscle_fiber1.11074460
66MP0002877_abnormal_melanocyte_morpholog1.10325991
67MP0004185_abnormal_adipocyte_glucose1.07464834
68MP0003646_muscle_fatigue1.07137235
69MP0000049_abnormal_middle_ear1.06912641
70MP0002019_abnormal_tumor_incidence1.06909255
71MP0000678_abnormal_parathyroid_gland1.06097907
72MP0009672_abnormal_birth_weight1.03892151
73MP0002210_abnormal_sex_determination1.03636914
74MP0003656_abnormal_erythrocyte_physiolo1.02957062
75MP0009250_abnormal_appendicular_skeleto1.01695530
76MP0001346_abnormal_lacrimal_gland1.01293208
77MP0002111_abnormal_tail_morphology1.01239903
78MP0002108_abnormal_muscle_morphology1.00756507
79MP0003221_abnormal_cardiomyocyte_apopto1.00659323
80MP0010630_abnormal_cardiac_muscle0.99970327
81MP0001293_anophthalmia0.98558440
82MP0010307_abnormal_tumor_latency0.96124341
83MP0000428_abnormal_craniofacial_morphol0.96080789
84MP0006054_spinal_hemorrhage0.95900378
85MP0002653_abnormal_ependyma_morphology0.94798393
86MP0002106_abnormal_muscle_physiology0.92579303
87MP0000747_muscle_weakness0.91572460
88MP0005330_cardiomyopathy0.91268089
89MP0000003_abnormal_adipose_tissue0.90606422
90MP0003937_abnormal_limbs/digits/tail_de0.90533807
91MP0001145_abnormal_male_reproductive0.90496474
92MP0000733_abnormal_muscle_development0.90371984
93MP0009384_cardiac_valve_regurgitation0.90017388
94MP0005397_hematopoietic_system_phenotyp0.89450815
95MP0001545_abnormal_hematopoietic_system0.89450815
96MP0003566_abnormal_cell_adhesion0.88221013
97MP0001727_abnormal_embryo_implantation0.88207444
98MP0000703_abnormal_thymus_morphology0.86761962
99MP0001299_abnormal_eye_distance/0.86617098
100MP0003115_abnormal_respiratory_system0.86371445
101MP0005369_muscle_phenotype0.86339959
102MP0000762_abnormal_tongue_morphology0.84735081
103MP0001286_abnormal_eye_development0.84614087
104MP0005197_abnormal_uvea_morphology0.84440610
105MP0008770_decreased_survivor_rate0.82677338
106MP0005023_abnormal_wound_healing0.82471447
107MP0003315_abnormal_perineum_morphology0.82157859
108MP0005220_abnormal_exocrine_pancreas0.82143818
109MP0002925_abnormal_cardiovascular_devel0.81881847
110MP0003890_abnormal_embryonic-extraembry0.81766809
111MP0005384_cellular_phenotype0.81735084
112MP0002269_muscular_atrophy0.79457806
113MP0009053_abnormal_anal_canal0.77422048
114MP0003941_abnormal_skin_development0.75367460
115MP0000432_abnormal_head_morphology0.75202353
116MP0008438_abnormal_cutaneous_collagen0.74602394
117MP0001849_ear_inflammation0.74496338
118MP0004233_abnormal_muscle_weight0.74450448
119MP0004084_abnormal_cardiac_muscle0.72667196
120MP0002932_abnormal_joint_morphology0.72303199
121MP0003755_abnormal_palate_morphology0.72234212
122MP0003806_abnormal_nucleotide_metabolis0.71720364
123MP0001944_abnormal_pancreas_morphology0.71198358
124MP0002114_abnormal_axial_skeleton0.70393323
125MP0000653_abnormal_sex_gland0.69971479
126MP0003935_abnormal_craniofacial_develop0.69935845
127MP0005621_abnormal_cell_physiology0.69693785
128MP0005508_abnormal_skeleton_morphology0.68942026
129MP0002160_abnormal_reproductive_system0.68620231
130MP0002116_abnormal_craniofacial_bone0.67191300
131MP0000858_altered_metastatic_potential0.66725394
132MP0001243_abnormal_dermal_layer0.66129946
133MP0008260_abnormal_autophagy0.65852180
134MP0003385_abnormal_body_wall0.64640022
135MP0005257_abnormal_intraocular_pressure0.64165111
136MP0002075_abnormal_coat/hair_pigmentati0.64066857
137MP0002722_abnormal_immune_system0.63536676
138MP0009703_decreased_birth_body0.63074484
139MP0001915_intracranial_hemorrhage0.62446789
140MP0003705_abnormal_hypodermis_morpholog0.61944104

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.38327868
2Cerebral hypomyelination (HP:0006808)4.03165143
3Abnormality of cells of the erythroid lineage (HP:0012130)3.94702197
4Breast hypoplasia (HP:0003187)3.86252638
5Abnormal number of erythroid precursors (HP:0012131)3.83552179
6Carpal bone hypoplasia (HP:0001498)3.35300069
7Reticulocytopenia (HP:0001896)3.20162339
8Patellar aplasia (HP:0006443)3.16820827
911 pairs of ribs (HP:0000878)3.05765861
10Rough bone trabeculation (HP:0100670)3.03983100
11Aplasia/Hypoplasia of the patella (HP:0006498)3.01503913
12Trismus (HP:0000211)2.91868170
13Colon cancer (HP:0003003)2.90673554
14Aplastic anemia (HP:0001915)2.86180717
15Missing ribs (HP:0000921)2.85304676
16CNS hypomyelination (HP:0003429)2.83926430
17Slender long bone (HP:0003100)2.81984635
18Selective tooth agenesis (HP:0001592)2.80634952
19Exercise-induced muscle cramps (HP:0003710)2.78084127
20Ependymoma (HP:0002888)2.77374916
21Abnormality of the labia minora (HP:0012880)2.75577112
22Glossoptosis (HP:0000162)2.71060083
23Degeneration of anterior horn cells (HP:0002398)2.64882202
24Abnormality of the anterior horn cell (HP:0006802)2.64882202
25Calcaneovalgus deformity (HP:0001848)2.63798030
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60745147
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60745147
28Macrocytic anemia (HP:0001972)2.53803793
29Hyperacusis (HP:0010780)2.51797721
30Exercise-induced myalgia (HP:0003738)2.47983094
31Disproportionate tall stature (HP:0001519)2.47097439
32Premature rupture of membranes (HP:0001788)2.45431730
33Spinal cord lesions (HP:0100561)2.45254105
34Syringomyelia (HP:0003396)2.45254105
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43349122
36Pallor (HP:0000980)2.43216931
37Pelvic girdle muscle weakness (HP:0003749)2.42369896
38Renal duplication (HP:0000075)2.41938211
39Abnormality of the umbilical cord (HP:0010881)2.38587512
40Secondary amenorrhea (HP:0000869)2.37993463
41Abnormality of the calcaneus (HP:0008364)2.37162307
42Facial hemangioma (HP:0000329)2.36091374
43Absent thumb (HP:0009777)2.35433631
44Abnormality of the left ventricular outflow tract (HP:0011103)2.33564910
45Subaortic stenosis (HP:0001682)2.33564910
46Shoulder girdle muscle weakness (HP:0003547)2.33168452
47Chromsome breakage (HP:0040012)2.32150279
48Delayed cranial suture closure (HP:0000270)2.28165962
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.27796268
50Soft skin (HP:0000977)2.26703498
51Abdominal situs inversus (HP:0003363)2.25720334
52Abnormality of abdominal situs (HP:0011620)2.25720334
53Protrusio acetabuli (HP:0003179)2.25563690
54Asymmetry of the thorax (HP:0001555)2.25408979
55Neoplasm of the pancreas (HP:0002894)2.24669196
56Absent radius (HP:0003974)2.24405524
57Thrombocytosis (HP:0001894)2.24370169
58Microretrognathia (HP:0000308)2.23962168
59Deformed tarsal bones (HP:0008119)2.23507606
60Type 1 muscle fiber predominance (HP:0003803)2.22470139
61Delayed closure of the anterior fontanelle (HP:0001476)2.21310490
62Premature skin wrinkling (HP:0100678)2.20907548
63Oral leukoplakia (HP:0002745)2.20898324
64Spinal rigidity (HP:0003306)2.19810372
65Postnatal microcephaly (HP:0005484)2.18487008
66Sparse lateral eyebrow (HP:0005338)2.17049192
67Ulnar bowing (HP:0003031)2.17014730
68Bladder diverticulum (HP:0000015)2.12304267
69Atrophy/Degeneration involving motor neurons (HP:0007373)2.11948878
70Increased nuchal translucency (HP:0010880)2.10849099
71Progressive muscle weakness (HP:0003323)2.10501634
72Supernumerary spleens (HP:0009799)2.09580837
73Stenosis of the external auditory canal (HP:0000402)2.08067124
74Multiple enchondromatosis (HP:0005701)2.07929948
75Turricephaly (HP:0000262)2.05500045
76Absent forearm bone (HP:0003953)2.04571622
77Aplasia involving forearm bones (HP:0009822)2.04571622
78Flat cornea (HP:0007720)2.04139552
79Difficulty climbing stairs (HP:0003551)2.03567542
80Poor head control (HP:0002421)2.02995233
81Abnormality of the hip-girdle musculature (HP:0001445)2.02396629
82Abnormality of the musculature of the pelvis (HP:0001469)2.02396629
83Ankle contracture (HP:0006466)2.02337336
84Premature ovarian failure (HP:0008209)2.01423385
85Amaurosis fugax (HP:0100576)2.00736107
86Abnormality of reticulocytes (HP:0004312)2.00733430
87Reticulocytosis (HP:0001923)2.00583074
88Metaphyseal cupping (HP:0003021)1.99839774
89Thin ribs (HP:0000883)1.98508775
90Broad distal phalanx of finger (HP:0009836)1.98421303
91Abnormal trabecular bone morphology (HP:0100671)1.94622718
92Horseshoe kidney (HP:0000085)1.93609138
93Myelodysplasia (HP:0002863)1.93427864
94Protruding ear (HP:0000411)1.93187343
95Long eyelashes (HP:0000527)1.92782688
96Meckel diverticulum (HP:0002245)1.92563414
97Shallow orbits (HP:0000586)1.92476877
98Self-mutilation (HP:0000742)1.92452736
99Biconcave vertebral bodies (HP:0004586)1.92180961
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91902257
101High anterior hairline (HP:0009890)1.91421152
102Abnormality of dentin (HP:0010299)1.90999037
103Ragged-red muscle fibers (HP:0003200)1.90649550
104Overlapping toe (HP:0001845)1.90568345
105Medulloblastoma (HP:0002885)1.88394349
106Fused cervical vertebrae (HP:0002949)1.88256313
107Atresia of the external auditory canal (HP:0000413)1.87677459
108Abnormality of the preputium (HP:0100587)1.87098573
109Premature graying of hair (HP:0002216)1.86714295
110Short palpebral fissure (HP:0012745)1.85953000
111Ureteral duplication (HP:0000073)1.83482205
112Abnormality of the phalanges of the hallux (HP:0010057)1.83025968
113Aplasia/hypoplasia of the humerus (HP:0006507)1.82699192
114Insomnia (HP:0100785)1.82578989
115Stillbirth (HP:0003826)1.81434604
116Microvesicular hepatic steatosis (HP:0001414)1.81203086
117Irregular epiphyses (HP:0010582)1.80839623
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.78905081
119Myopathic facies (HP:0002058)1.78281754
120Mitral valve prolapse (HP:0001634)1.78158659
121Agnosia (HP:0010524)1.78094391
122Bowel diverticulosis (HP:0005222)1.77429872
123Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.77395738
124Abnormality of the distal phalanges of the toes (HP:0010182)1.77238548
125Metatarsus adductus (HP:0001840)1.77042085
126Rhabdomyosarcoma (HP:0002859)1.76783710
127Aplasia/hypoplasia of the uterus (HP:0008684)1.76672070
128Proximal placement of thumb (HP:0009623)1.76657981
129Deviation of the thumb (HP:0009603)1.76353023
130Hypoplasia of the radius (HP:0002984)1.75475749
131Increased connective tissue (HP:0009025)1.75350258
132Flat capital femoral epiphysis (HP:0003370)1.74788549
133Abnormality of glycolysis (HP:0004366)1.73254800
134Basal cell carcinoma (HP:0002671)1.70854010
135Short middle phalanx of the 5th finger (HP:0004220)1.70541289
136Nephroblastoma (Wilms tumor) (HP:0002667)1.70256104
137Abnormality of the ileum (HP:0001549)1.70066359
138Fragile skin (HP:0001030)1.69879595
139Round ear (HP:0100830)1.69056190
140Cortical dysplasia (HP:0002539)1.68833612
141Distal lower limb amyotrophy (HP:0008944)1.68542754
142Increased serum pyruvate (HP:0003542)1.68334254
143Small epiphyses (HP:0010585)1.68036759
144Prominent metopic ridge (HP:0005487)1.67543193
145Adducted thumb (HP:0001181)1.67336642
146Abnormal number of incisors (HP:0011064)1.67240067
147Abnormality of the distal phalanx of the thumb (HP:0009617)1.67088293
148Centrally nucleated skeletal muscle fibers (HP:0003687)1.66655877
149Personality changes (HP:0000751)1.66482054
150Rib fusion (HP:0000902)1.66214094
151Cervical subluxation (HP:0003308)1.66109853
152Aplasia/Hypoplasia involving the musculature (HP:0001460)1.66106709
153Pterygium (HP:0001059)1.65605894
154Breech presentation (HP:0001623)1.64519418
155Overriding aorta (HP:0002623)1.64248676
156Broad thumb (HP:0011304)1.63949135
157Muscle fiber inclusion bodies (HP:0100299)1.63783110
158Muscle fiber atrophy (HP:0100295)1.63256166
159Aortic dissection (HP:0002647)1.62830841
160Embryonal renal neoplasm (HP:0011794)1.62244543
161Calf muscle hypertrophy (HP:0008981)1.60588468
162Aortic aneurysm (HP:0004942)1.59976388
163Distal arthrogryposis (HP:0005684)1.59938353
164Broad phalanges of the hand (HP:0009768)1.59034316
165Renovascular hypertension (HP:0100817)1.58299073
166Nemaline bodies (HP:0003798)1.58281724
167Elfin facies (HP:0004428)1.55423094
168Brushfield spots (HP:0001088)1.55177640
169Short 5th finger (HP:0009237)1.54656769
170Abnormal gallbladder physiology (HP:0012438)1.54221028
171Cholecystitis (HP:0001082)1.54221028
172Redundant skin (HP:0001582)1.54099287
173Muscle stiffness (HP:0003552)1.53385768
174Blue sclerae (HP:0000592)1.52857165
175Acute lymphatic leukemia (HP:0006721)1.52084065
176Duplication of thumb phalanx (HP:0009942)1.52003175
177Abnormality of homocysteine metabolism (HP:0010919)1.51542223
178Homocystinuria (HP:0002156)1.51542223
179Obsessive-compulsive behavior (HP:0000722)1.51226269
180Broad finger (HP:0001500)1.50070189
181Elbow flexion contracture (HP:0002987)1.49820325
182Abnormality of the acetabulum (HP:0003170)1.49182799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.60579452
2NME23.91323230
3SMG13.40371848
4WEE13.34719528
5CDC73.29319187
6TSSK62.87325329
7TESK22.53937435
8EIF2AK12.53833397
9NEK22.49269485
10VRK22.35259762
11SRPK12.29191801
12ICK2.19155031
13PASK2.09314426
14EPHA21.97493108
15MAP3K131.93644321
16CDK121.84514991
17IRAK31.82188958
18PLK41.82172764
19ACVR1B1.80646957
20TRIB31.77022956
21STK161.76679737
22PIM21.74854156
23TLK11.67729073
24DYRK31.66480000
25SCYL21.61353604
26PBK1.61290215
27TTK1.61193025
28PLK11.58987435
29PDGFRA1.57999357
30BRSK21.57894707
31TAF11.56691031
32MKNK11.54200499
33EIF2AK31.53209120
34MAPKAPK51.51226273
35MAP3K31.50532113
36CDK71.43212023
37AURKA1.42136660
38MAP2K31.32958647
39LATS21.27779312
40AURKB1.26433915
41MAP3K81.22888890
42TGFBR11.22590804
43NTRK11.19463457
44CHEK21.18971422
45PKN21.18270167
46RPS6KA41.15580245
47BRD41.14449663
48ATR1.10579625
49CHEK11.10233781
50MKNK21.09219990
51CDK41.09000567
52RPS6KB21.08454631
53PRPF4B1.07033219
54KDR1.06641271
55ZAP701.04909908
56CLK11.03254020
57MAP3K111.01583161
58VRK10.99642556
59CDK60.98477298
60PAK40.98298846
61DYRK20.97843279
62FLT30.97203821
63STK100.95681971
64MAP3K100.92821001
65NEK10.90399466
66EEF2K0.88807621
67TAOK20.87833623
68PLK30.87276967
69PAK10.84705632
70BRSK10.84356554
71NME10.84355167
72FGFR40.83992990
73CDK20.83055644
74ERBB40.81948308
75CDK190.80987763
76MTOR0.80312293
77LATS10.80146173
78AKT30.75108979
79ILK0.74396370
80BRAF0.73773994
81PAK20.73655219
82CSNK2A20.71926409
83TESK10.71843058
84RPS6KA50.69616575
85MAP2K20.68990635
86PIM10.68505040
87CDK90.67834568
88TYRO30.66839050
89MAPKAPK30.65427582
90TTN0.65204227
91ALK0.62651381
92PNCK0.61925374
93ATM0.61862473
94LIMK10.61615774
95PRKCI0.60577180
96CCNB10.60544604
97MAP3K70.60040146
98DMPK0.59818708
99STK38L0.57936932
100MAP3K140.57070852
101DAPK30.56306044
102PTK20.55533319
103WNK30.54342396
104FGFR10.53995196
105CSNK1A1L0.53852239
106CSNK2A10.53606904
107LRRK20.53521204
108MAPK110.52712111
109CSNK1E0.51342018
110NEK90.51078745
111MET0.50144547
112MELK0.49038699
113MAP3K50.48847839
114MUSK0.48785059
115ZAK0.47457793
116CDK10.47382708
117CSNK1G30.46630206
118CAMK1G0.45687724
119ARAF0.44813532
120DDR20.44703307
121AKT20.44693680
122STK30.44556064
123DYRK1B0.44437346
124PIK3CG0.44340775
125STK40.44189775
126BCKDK0.42667032
127PTK60.41267006
128EIF2AK20.39531263
129RAF10.37725738
130MOS0.37199369
131RPS6KB10.37085904
132MAP4K10.36581489
133CSNK1G10.36436410
134RPS6KA10.34929032
135CDK80.34129460

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.11640852
2* RNA polymerase_Homo sapiens_hsa030203.98684856
3DNA replication_Homo sapiens_hsa030303.54485244
4Proteasome_Homo sapiens_hsa030503.51660069
5Ribosome_Homo sapiens_hsa030103.47714708
6Spliceosome_Homo sapiens_hsa030403.40589532
7RNA transport_Homo sapiens_hsa030133.27203629
8Mismatch repair_Homo sapiens_hsa034303.17189664
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.08120853
10* Pyrimidine metabolism_Homo sapiens_hsa002402.43802504
11Homologous recombination_Homo sapiens_hsa034402.39995152
12Cell cycle_Homo sapiens_hsa041102.39961536
13Nucleotide excision repair_Homo sapiens_hsa034202.27154977
14Base excision repair_Homo sapiens_hsa034102.26129228
15One carbon pool by folate_Homo sapiens_hsa006702.18690628
16Protein export_Homo sapiens_hsa030601.93052370
17Basal transcription factors_Homo sapiens_hsa030221.91006396
18RNA degradation_Homo sapiens_hsa030181.86288575
19mRNA surveillance pathway_Homo sapiens_hsa030151.71806053
20Folate biosynthesis_Homo sapiens_hsa007901.62266739
21p53 signaling pathway_Homo sapiens_hsa041151.61914385
22Fanconi anemia pathway_Homo sapiens_hsa034601.46025112
23Non-homologous end-joining_Homo sapiens_hsa034501.41215696
24* Epstein-Barr virus infection_Homo sapiens_hsa051691.38936765
25Lysine degradation_Homo sapiens_hsa003101.32526006
26* Purine metabolism_Homo sapiens_hsa002301.23390588
27* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20757632
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16950993
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13072353
30Pancreatic cancer_Homo sapiens_hsa052121.10850344
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09451417
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08145788
33Fructose and mannose metabolism_Homo sapiens_hsa000511.07153873
34Maturity onset diabetes of the young_Homo sapiens_hsa049500.97229860
35Viral carcinogenesis_Homo sapiens_hsa052030.95737155
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.89287686
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88319756
38Adherens junction_Homo sapiens_hsa045200.86196035
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83743767
40Focal adhesion_Homo sapiens_hsa045100.82295635
41Selenocompound metabolism_Homo sapiens_hsa004500.81467661
42Non-small cell lung cancer_Homo sapiens_hsa052230.81444771
43HTLV-I infection_Homo sapiens_hsa051660.78892079
44Antigen processing and presentation_Homo sapiens_hsa046120.78375556
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77110319
46Notch signaling pathway_Homo sapiens_hsa043300.75879408
47Vitamin B6 metabolism_Homo sapiens_hsa007500.73987312
48Pyruvate metabolism_Homo sapiens_hsa006200.73597826
49ErbB signaling pathway_Homo sapiens_hsa040120.72119073
50MicroRNAs in cancer_Homo sapiens_hsa052060.71683217
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71205925
52Bladder cancer_Homo sapiens_hsa052190.68057523
53Herpes simplex infection_Homo sapiens_hsa051680.67868579
54Biosynthesis of amino acids_Homo sapiens_hsa012300.67718123
55Systemic lupus erythematosus_Homo sapiens_hsa053220.67037099
56Glioma_Homo sapiens_hsa052140.66613702
57Sulfur relay system_Homo sapiens_hsa041220.66321405
58TGF-beta signaling pathway_Homo sapiens_hsa043500.66192837
59Oocyte meiosis_Homo sapiens_hsa041140.66145369
60Thyroid cancer_Homo sapiens_hsa052160.64557722
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63372848
62Melanoma_Homo sapiens_hsa052180.62751286
63Legionellosis_Homo sapiens_hsa051340.62539396
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62188174
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61405624
66Hippo signaling pathway_Homo sapiens_hsa043900.60642352
67Pentose phosphate pathway_Homo sapiens_hsa000300.59026861
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58780559
69Small cell lung cancer_Homo sapiens_hsa052220.58663349
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58286990
71Shigellosis_Homo sapiens_hsa051310.58084126
72Endometrial cancer_Homo sapiens_hsa052130.57974586
73Huntingtons disease_Homo sapiens_hsa050160.56197634
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54686086
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53582982
76Steroid biosynthesis_Homo sapiens_hsa001000.52170589
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.52057005
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51422056
79Regulation of autophagy_Homo sapiens_hsa041400.51218139
80Parkinsons disease_Homo sapiens_hsa050120.51146318
81FoxO signaling pathway_Homo sapiens_hsa040680.50635663
82Dilated cardiomyopathy_Homo sapiens_hsa054140.50177785
83N-Glycan biosynthesis_Homo sapiens_hsa005100.49191414
84Insulin signaling pathway_Homo sapiens_hsa049100.48768739
85AMPK signaling pathway_Homo sapiens_hsa041520.48586259
86Apoptosis_Homo sapiens_hsa042100.48542702
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47799257
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47030840
89Galactose metabolism_Homo sapiens_hsa000520.46023969
90Renal cell carcinoma_Homo sapiens_hsa052110.45830309
91Basal cell carcinoma_Homo sapiens_hsa052170.45413452
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45008984
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43405765
94Alcoholism_Homo sapiens_hsa050340.42348148
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41994275
96VEGF signaling pathway_Homo sapiens_hsa043700.39982057
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39868240
98Chronic myeloid leukemia_Homo sapiens_hsa052200.38181807
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.37013339
100Hepatitis B_Homo sapiens_hsa051610.36577147
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35943497
102Type I diabetes mellitus_Homo sapiens_hsa049400.35759089
103Acute myeloid leukemia_Homo sapiens_hsa052210.35147780
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33670240
105Colorectal cancer_Homo sapiens_hsa052100.32368436
106Hedgehog signaling pathway_Homo sapiens_hsa043400.32089976
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28653571
108Pathways in cancer_Homo sapiens_hsa052000.28637251
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.28276928
110Arginine and proline metabolism_Homo sapiens_hsa003300.27948614
111HIF-1 signaling pathway_Homo sapiens_hsa040660.27502644
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.27029970
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26860357
114Oxidative phosphorylation_Homo sapiens_hsa001900.25293152
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.25122557
116Carbon metabolism_Homo sapiens_hsa012000.24722611
117Measles_Homo sapiens_hsa051620.22698106
118mTOR signaling pathway_Homo sapiens_hsa041500.22555177
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21048917
120Proteoglycans in cancer_Homo sapiens_hsa052050.20950501
121Other glycan degradation_Homo sapiens_hsa005110.20569083
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20491127
123Wnt signaling pathway_Homo sapiens_hsa043100.19506156
124Prostate cancer_Homo sapiens_hsa052150.16937189
125Tight junction_Homo sapiens_hsa045300.16625077
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15325644
127* Metabolic pathways_Homo sapiens_hsa011000.14598523
128ECM-receptor interaction_Homo sapiens_hsa045120.14511134
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14374776
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14089505

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