POLR3E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ensheathment of neurons (GO:0007272)6.27937764
2axon ensheathment (GO:0008366)6.27937764
3myelination (GO:0042552)6.26079070
4fatty acid elongation (GO:0030497)6.09078751
5nuclear pore complex assembly (GO:0051292)4.79281403
6nuclear pore organization (GO:0006999)4.53536142
7myelin maintenance (GO:0043217)4.44029697
8regulation of translational fidelity (GO:0006450)4.29501112
9negative regulation of mRNA processing (GO:0050686)4.19554503
10establishment of mitochondrion localization (GO:0051654)4.16150949
11L-serine metabolic process (GO:0006563)4.13563461
12DNA unwinding involved in DNA replication (GO:0006268)4.11187897
13negative regulation of mRNA metabolic process (GO:1903312)4.08022482
14long-chain fatty acid biosynthetic process (GO:0042759)4.07742134
15creatine metabolic process (GO:0006600)4.00808936
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.91905800
17IMP biosynthetic process (GO:0006188)3.83691542
18ribosome assembly (GO:0042255)3.78869153
19folic acid-containing compound biosynthetic process (GO:0009396)3.75012222
20mitotic nuclear envelope disassembly (GO:0007077)3.70677955
21cholesterol biosynthetic process (GO:0006695)3.62589927
22regulation of translational termination (GO:0006449)3.61612732
23maturation of 5.8S rRNA (GO:0000460)3.61189358
24transcription from mitochondrial promoter (GO:0006390)3.52540169
25amyloid precursor protein metabolic process (GO:0042982)3.51517664
26pore complex assembly (GO:0046931)3.50727252
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.49945847
28proline biosynthetic process (GO:0006561)3.45413624
29mitochondrial RNA metabolic process (GO:0000959)3.44513284
30viral mRNA export from host cell nucleus (GO:0046784)3.43623617
31membrane disassembly (GO:0030397)3.39825800
32nuclear envelope disassembly (GO:0051081)3.39825800
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.38956125
34mitotic sister chromatid cohesion (GO:0007064)3.38734156
35regulation of collateral sprouting (GO:0048670)3.35964990
36DNA duplex unwinding (GO:0032508)3.33623667
37astrocyte development (GO:0014002)3.31317406
38DNA geometric change (GO:0032392)3.29336147
39mRNA cleavage (GO:0006379)3.25016670
40purine nucleobase biosynthetic process (GO:0009113)3.24515445
41protein palmitoylation (GO:0018345)3.21627053
42apical protein localization (GO:0045176)3.21621278
43negative regulation of neurotransmitter secretion (GO:0046929)3.19003605
44rRNA modification (GO:0000154)3.17707732
45sterol biosynthetic process (GO:0016126)3.16071284
46ribosomal small subunit biogenesis (GO:0042274)3.13251294
47tRNA aminoacylation for protein translation (GO:0006418)3.12775912
48histone H2B ubiquitination (GO:0033523)3.12508009
49positive regulation of oligodendrocyte differentiation (GO:0048714)3.12183203
50positive regulation of cell cycle checkpoint (GO:1901978)3.12006820
51DNA replication initiation (GO:0006270)3.11765055
52double-strand break repair via nonhomologous end joining (GO:0006303)3.11664826
53non-recombinational repair (GO:0000726)3.11664826
54tRNA aminoacylation (GO:0043039)3.10891054
55amino acid activation (GO:0043038)3.10891054
56substantia nigra development (GO:0021762)3.10265868
57asymmetric protein localization (GO:0008105)3.09730778
58negative regulation of RNA splicing (GO:0033119)3.08777502
59magnesium ion transport (GO:0015693)3.08342344
60glycerophospholipid catabolic process (GO:0046475)3.08087894
61regulation of histone H3-K27 methylation (GO:0061085)3.06200401
62mRNA export from nucleus (GO:0006406)3.06132092
63termination of RNA polymerase II transcription (GO:0006369)3.05615792
64oligodendrocyte differentiation (GO:0048709)3.04758202
65DNA topological change (GO:0006265)3.02729499
66DNA replication checkpoint (GO:0000076)3.02645404
67serine family amino acid biosynthetic process (GO:0009070)3.01443136
68RNA export from nucleus (GO:0006405)3.00110463
69telomere maintenance via semi-conservative replication (GO:0032201)2.99780215
70protein complex localization (GO:0031503)2.99091688
71cellular protein complex localization (GO:0034629)2.98900835
72response to methylmercury (GO:0051597)2.98549232
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.98329991
74GPI anchor biosynthetic process (GO:0006506)2.96977896
75regulation of mitotic spindle checkpoint (GO:1903504)2.96905152
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96905152
77rRNA methylation (GO:0031167)2.96771932
78virion attachment to host cell (GO:0019062)2.95744943
79adhesion of symbiont to host cell (GO:0044650)2.95744943
80peptidyl-cysteine modification (GO:0018198)2.95255430
81ribosomal large subunit biogenesis (GO:0042273)2.94400736
82pre-miRNA processing (GO:0031054)2.94264418
83regulation of mitochondrial translation (GO:0070129)2.93858987
84DNA strand elongation involved in DNA replication (GO:0006271)2.92291359
85isoprenoid biosynthetic process (GO:0008299)2.92106029
86L-amino acid import (GO:0043092)2.91421235
87mRNA transport (GO:0051028)2.91114026
88V(D)J recombination (GO:0033151)2.90927491
89DNA replication-dependent nucleosome organization (GO:0034723)2.89651277
90DNA replication-dependent nucleosome assembly (GO:0006335)2.89651277
91preassembly of GPI anchor in ER membrane (GO:0016254)2.87574398
92DNA conformation change (GO:0071103)2.87570212
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.85420699
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85420699
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82771955
96chaperone-mediated protein complex assembly (GO:0051131)2.82492568
97membrane tubulation (GO:0097320)2.81751570
98DNA strand elongation (GO:0022616)2.81733213
99IMP metabolic process (GO:0046040)2.81258040
100response to lead ion (GO:0010288)2.80350612
101viral transcription (GO:0019083)2.78832543
102negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78286409
103translational termination (GO:0006415)2.77329640
104microtubule polymerization or depolymerization (GO:0031109)2.76922280
105negative regulation of neurotransmitter transport (GO:0051589)2.75856928
106RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73913709
107protein polyglutamylation (GO:0018095)2.73698045
108mitotic sister chromatid segregation (GO:0000070)2.73357540
109peptidyl-histidine modification (GO:0018202)2.73075979
110nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.72379545
111tetrahydrofolate metabolic process (GO:0046653)2.71075092
112ribonucleoprotein complex biogenesis (GO:0022613)2.70882392
113rRNA processing (GO:0006364)2.70678841
114pseudouridine synthesis (GO:0001522)2.70616938
115nucleobase biosynthetic process (GO:0046112)2.70512694
116regulation of histone H3-K4 methylation (GO:0051569)2.70263700
117nuclear envelope organization (GO:0006998)2.70077588
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.69904406
119centrosome duplication (GO:0051298)2.69829169
120DNA ligation (GO:0006266)2.68290210
121maturation of SSU-rRNA (GO:0030490)2.67637166
122spliceosomal tri-snRNP complex assembly (GO:0000244)2.66887582
123amino acid salvage (GO:0043102)2.65980191
124L-methionine salvage (GO:0071267)2.65980191
125L-methionine biosynthetic process (GO:0071265)2.65980191
126rRNA catabolic process (GO:0016075)2.65916712
127mitochondrial DNA metabolic process (GO:0032042)2.65357833
128pteridine-containing compound biosynthetic process (GO:0042559)2.65007729
129long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.64821911
130RNA transport (GO:0050658)2.64598629
131establishment of RNA localization (GO:0051236)2.64598629
132nucleic acid transport (GO:0050657)2.64598629
133GPI anchor metabolic process (GO:0006505)2.64389113
134presynaptic membrane organization (GO:0097090)2.63948885
135negative regulation of histone methylation (GO:0031061)2.63903988
136telomere maintenance via recombination (GO:0000722)2.62491940
137RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.62412692
138mRNA splicing, via spliceosome (GO:0000398)2.62412692
139establishment of integrated proviral latency (GO:0075713)2.62211961
140nuclear export (GO:0051168)2.61794824
141glutamine metabolic process (GO:0006541)2.61672824
142regulation of translational elongation (GO:0006448)2.61302308
143rRNA transcription (GO:0009303)2.60838836
144RNA splicing, via transesterification reactions (GO:0000375)2.59868571
145nuclear envelope reassembly (GO:0031468)2.59744973
146mitotic nuclear envelope reassembly (GO:0007084)2.59744973
147sister chromatid segregation (GO:0000819)2.59156226
148folic acid metabolic process (GO:0046655)2.58861228
149regulation of DNA damage checkpoint (GO:2000001)2.58554183
150somatic cell DNA recombination (GO:0016444)2.58485559
151somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.58485559
152rRNA metabolic process (GO:0016072)2.58436953
153positive regulation of mRNA catabolic process (GO:0061014)2.56767463
154regulation of spindle checkpoint (GO:0090231)2.56218433
155proline metabolic process (GO:0006560)2.55365683
156tRNA methylation (GO:0030488)2.55308052
157pentose-phosphate shunt (GO:0006098)2.54447658
158mRNA 3-end processing (GO:0031124)2.54441871
159folic acid-containing compound metabolic process (GO:0006760)2.54283116
160fatty-acyl-CoA biosynthetic process (GO:0046949)2.54132478
161cotranslational protein targeting to membrane (GO:0006613)2.52526185
162regulation of RNA export from nucleus (GO:0046831)2.51963038
163translational initiation (GO:0006413)2.50040432
164ribosome biogenesis (GO:0042254)2.49758101
165glial cell development (GO:0021782)2.48543854
166translational elongation (GO:0006414)2.48013708
167cellular modified amino acid biosynthetic process (GO:0042398)2.47599654
168protein targeting to ER (GO:0045047)2.46576016
169response to redox state (GO:0051775)2.46455306
170NADPH regeneration (GO:0006740)2.45204636
171mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.45178010
172glutathione biosynthetic process (GO:0006750)2.44804896
173negative regulation of inclusion body assembly (GO:0090084)2.44693400
174regulation of exit from mitosis (GO:0007096)2.44075943
175formation of translation preinitiation complex (GO:0001731)2.42066926
176establishment of protein localization to endoplasmic reticulum (GO:0072599)2.40993716
177neuronal ion channel clustering (GO:0045161)2.40126572
178negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.39962217
179histone H4 deacetylation (GO:0070933)2.39739165
180oligodendrocyte development (GO:0014003)2.39690027
181axon ensheathment in central nervous system (GO:0032291)10.9804164
182central nervous system myelination (GO:0022010)10.9804164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.96949220
2E2F7_22180533_ChIP-Seq_HELA_Human4.68059458
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11571804
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24042422
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20108014
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15072985
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.11394660
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.11361263
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04618211
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97317835
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.92835078
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92409644
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86487054
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.80142751
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.78307412
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70882004
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.61716018
18XRN2_22483619_ChIP-Seq_HELA_Human2.61088200
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42641574
20* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30426039
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25992774
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.18439295
23AR_21909140_ChIP-Seq_LNCAP_Human2.11048153
24* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10850485
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08604135
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00888945
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00888945
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00888945
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93900795
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93285876
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90718588
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88192404
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88152676
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85497435
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.84076365
36* VDR_23849224_ChIP-Seq_CD4+_Human1.81215303
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77163860
38DCP1A_22483619_ChIP-Seq_HELA_Human1.76375877
39* GABP_19822575_ChIP-Seq_HepG2_Human1.70970848
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70757138
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.69365512
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64865084
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62629927
44FOXP3_21729870_ChIP-Seq_TREG_Human1.61835970
45KDM5A_27292631_Chip-Seq_BREAST_Human1.60676686
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60163494
47* TTF2_22483619_ChIP-Seq_HELA_Human1.55393829
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54999236
49CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.54294090
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49622827
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47402260
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44928255
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44891161
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43583990
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43393022
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42972895
57ELK1_19687146_ChIP-ChIP_HELA_Human1.38699586
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35357719
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34987980
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34071145
61* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32841066
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29947714
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27689431
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27578732
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25362316
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.24732568
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.23852843
68* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22508394
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21907138
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21827584
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21121239
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20640688
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20164684
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.19525796
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19361247
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19057449
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.18932725
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17612350
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.16895790
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16003880
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15812446
82* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14616153
83* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11746618
84MYC_22102868_ChIP-Seq_BL_Human1.11354268
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.08310009
86SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07363001
87IRF1_19129219_ChIP-ChIP_H3396_Human1.06831112
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06700053
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06305932
90ZNF263_19887448_ChIP-Seq_K562_Human1.05810730
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04484731
92CHD1_26751641_Chip-Seq_LNCaP_Human1.04350625
93* MYB_26560356_Chip-Seq_TH1_Human1.03493119
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02688507
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01745112
96STAT1_20625510_ChIP-Seq_HELA_Human1.01653519
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01312540
98* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00960622
99MYC_18940864_ChIP-ChIP_HL60_Human1.00952889
100TFEB_21752829_ChIP-Seq_HELA_Human1.00778963
101EOMES_21245162_ChIP-Seq_HESCs_Human0.99396019
102* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99148562
103NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98368106
104GATA1_26923725_Chip-Seq_HPCs_Mouse0.98132179
105VDR_21846776_ChIP-Seq_THP-1_Human0.98059987
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97699907
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97020647
108SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96787306
109TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95982927
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95807440
111* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95197631
112CIITA_25753668_ChIP-Seq_RAJI_Human0.94789742
113NCOR1_26117541_ChIP-Seq_K562_Human0.93715791
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93082706
115PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92867280
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92682993
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91090961
118MYB_26560356_Chip-Seq_TH2_Human0.90818289
119CTCF_20526341_ChIP-Seq_ESCs_Human0.90067123
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.89317450
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89130774
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89003194
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88015455
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87742342
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87710324
126* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87491567
127* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86516103
128* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86389054
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85432282
130MAF_26560356_Chip-Seq_TH1_Human0.83531379
131MAF_26560356_Chip-Seq_TH2_Human0.82248434
132KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81195402
133* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80477659
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79815530
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79193119
136NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77540287
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77104372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.66224227
2MP0003806_abnormal_nucleotide_metabolis3.76282931
3MP0008057_abnormal_DNA_replication3.23382272
4MP0002009_preneoplasia3.10046235
5MP0003950_abnormal_plasma_membrane2.92946685
6MP0004043_abnormal_pH_regulation2.78380734
7MP0004957_abnormal_blastocyst_morpholog2.64444343
8MP0004885_abnormal_endolymph2.63776641
9MP0008007_abnormal_cellular_replicative2.47774691
10MP0003329_amyloid_beta_deposits2.35349646
11MP0005410_abnormal_fertilization2.33174631
12MP0001485_abnormal_pinna_reflex2.31236934
13MP0001529_abnormal_vocalization2.20849467
14MP0000462_abnormal_digestive_system2.18314614
15MP0008995_early_reproductive_senescence2.17105344
16MP0008932_abnormal_embryonic_tissue2.14557608
17MP0006035_abnormal_mitochondrial_morpho2.10682185
18MP0003763_abnormal_thymus_physiology2.09921904
19MP0001730_embryonic_growth_arrest2.04310287
20MP0005423_abnormal_somatic_nervous1.96966536
21MP0010094_abnormal_chromosome_stability1.89421856
22MP0003690_abnormal_glial_cell1.88980986
23MP0004142_abnormal_muscle_tone1.86698684
24MP0003111_abnormal_nucleus_morphology1.83626752
25MP0004134_abnormal_chest_morphology1.79170095
26MP0004147_increased_porphyrin_level1.78691255
27MP0001661_extended_life_span1.78010583
28MP0003634_abnormal_glial_cell1.77369491
29MP0000747_muscle_weakness1.76389457
30MP0003136_yellow_coat_color1.73636023
31MP0004742_abnormal_vestibular_system1.71012446
32MP0003077_abnormal_cell_cycle1.70498834
33MP0002166_altered_tumor_susceptibility1.68163913
34MP0002653_abnormal_ependyma_morphology1.65521920
35MP0003632_abnormal_nervous_system1.65053899
36MP0000703_abnormal_thymus_morphology1.61158011
37MP0001873_stomach_inflammation1.60682064
38MP0009333_abnormal_splenocyte_physiolog1.59456262
39MP0001905_abnormal_dopamine_level1.57181274
40MP0001293_anophthalmia1.56827612
41MP0003123_paternal_imprinting1.55270538
42MP0006036_abnormal_mitochondrial_physio1.52031562
43MP0004270_analgesia1.51976289
44MP0009697_abnormal_copulation1.50596673
45MP0009672_abnormal_birth_weight1.48855815
46MP0010678_abnormal_skin_adnexa1.47425526
47MP0008877_abnormal_DNA_methylation1.47039527
48MP0000778_abnormal_nervous_system1.45177584
49MP0003646_muscle_fatigue1.43603607
50MP0010307_abnormal_tumor_latency1.40716591
51MP0004145_abnormal_muscle_electrophysio1.37422606
52MP0008260_abnormal_autophagy1.37206718
53MP0002088_abnormal_embryonic_growth/wei1.36596373
54MP0002229_neurodegeneration1.36448747
55MP0003693_abnormal_embryo_hatching1.36212797
56MP0004233_abnormal_muscle_weight1.35580747
57MP0002019_abnormal_tumor_incidence1.35210419
58MP0002272_abnormal_nervous_system1.34775028
59MP0001727_abnormal_embryo_implantation1.33689308
60MP0002396_abnormal_hematopoietic_system1.32618710
61MP0001348_abnormal_lacrimal_gland1.29591363
62MP0000383_abnormal_hair_follicle1.28622968
63MP0004381_abnormal_hair_follicle1.27250747
64MP0002254_reproductive_system_inflammat1.27074838
65MP0004133_heterotaxia1.27035191
66MP0000537_abnormal_urethra_morphology1.26683486
67MP0005623_abnormal_meninges_morphology1.25427055
68MP0003880_abnormal_central_pattern1.23071490
69MP0001697_abnormal_embryo_size1.22111487
70MP0001929_abnormal_gametogenesis1.20310041
71MP0001145_abnormal_male_reproductive1.19875524
72MP0002084_abnormal_developmental_patter1.19862875
73MP0005076_abnormal_cell_differentiation1.19166748
74MP0002086_abnormal_extraembryonic_tissu1.18761320
75MP0002085_abnormal_embryonic_tissue1.18118888
76MP0004808_abnormal_hematopoietic_stem1.17955528
77MP0000350_abnormal_cell_proliferation1.16893474
78MP0002006_tumorigenesis1.15416447
79MP0000372_irregular_coat_pigmentation1.15022678
80MP0003698_abnormal_male_reproductive1.14132116
81MP0000955_abnormal_spinal_cord1.14078200
82MP0002210_abnormal_sex_determination1.12625747
83MP0008058_abnormal_DNA_repair1.12323204
84MP0001764_abnormal_homeostasis1.12242093
85MP0003718_maternal_effect1.11626367
86MP0003937_abnormal_limbs/digits/tail_de1.10036057
87MP0001486_abnormal_startle_reflex1.05984935
88MP0002398_abnormal_bone_marrow1.05917081
89MP0002163_abnormal_gland_morphology1.04790856
90MP0002080_prenatal_lethality1.02823015
91MP0004185_abnormal_adipocyte_glucose1.02775027
92MP0002722_abnormal_immune_system1.02746334
93MP0001299_abnormal_eye_distance/1.01255998
94MP0003121_genomic_imprinting1.00388026
95MP0005451_abnormal_body_composition0.99743061
96MP0001853_heart_inflammation0.99191295
97MP0000467_abnormal_esophagus_morphology0.99068518
98MP0000689_abnormal_spleen_morphology0.98481876
99MP0003786_premature_aging0.97989462
100MP0005075_abnormal_melanosome_morpholog0.97815328
101MP0010234_abnormal_vibrissa_follicle0.97485876
102MP0010352_gastrointestinal_tract_polyps0.96613067
103MP0003861_abnormal_nervous_system0.95580411
104MP0001672_abnormal_embryogenesis/_devel0.94991086
105MP0005380_embryogenesis_phenotype0.94991086
106MP0004264_abnormal_extraembryonic_tissu0.93804560
107MP0003172_abnormal_lysosome_physiology0.93594438
108MP0002269_muscular_atrophy0.93571649
109MP0005379_endocrine/exocrine_gland_phen0.93497963
110MP0005171_absent_coat_pigmentation0.92615133
111MP0003938_abnormal_ear_development0.91670571
112MP0005360_urolithiasis0.91543334
113MP0000604_amyloidosis0.90788426
114MP0002092_abnormal_eye_morphology0.89098298
115MP0005332_abnormal_amino_acid0.89019876
116MP0005058_abnormal_lysosome_morphology0.87261656
117MP0002882_abnormal_neuron_morphology0.86442721
118MP0002064_seizures0.85596983
119MP0000653_abnormal_sex_gland0.84544883
120MP0009703_decreased_birth_body0.84436264
121MP0003656_abnormal_erythrocyte_physiolo0.83424064
122MP0002970_abnormal_white_adipose0.83068983
123MP0002066_abnormal_motor_capabilities/c0.82462463
124MP0003631_nervous_system_phenotype0.81915885
125MP0002752_abnormal_somatic_nervous0.81710098
126MP0004197_abnormal_fetal_growth/weight/0.81080890
127MP0002161_abnormal_fertility/fecundity0.80853875
128MP0003221_abnormal_cardiomyocyte_apopto0.80648046
129MP0001849_ear_inflammation0.80363322
130MP0000609_abnormal_liver_physiology0.79603957
131MP0005384_cellular_phenotype0.79294245
132MP0000003_abnormal_adipose_tissue0.79008951
133MP0005501_abnormal_skin_physiology0.76803663
134MP0002152_abnormal_brain_morphology0.76218327
135MP0003315_abnormal_perineum_morphology0.75943831
136MP0000358_abnormal_cell_content/0.75835818
137MP0010630_abnormal_cardiac_muscle0.75789675
138MP0003890_abnormal_embryonic-extraembry0.75648969
139MP0000647_abnormal_sebaceous_gland0.74855776
140MP0003984_embryonic_growth_retardation0.74584051
141MP0003567_abnormal_fetal_cardiomyocyte0.74432775
142MP0005395_other_phenotype0.74238027
143MP0008961_abnormal_basal_metabolism0.73450532
144MP0005409_darkened_coat_color0.73359274
145MP0000598_abnormal_liver_morphology0.72824746
146MP0000313_abnormal_cell_death0.72233306
147MP0002429_abnormal_blood_cell0.71890485
148MP0003699_abnormal_female_reproductive0.70328785
149MP0005220_abnormal_exocrine_pancreas0.69807647
150MP0005310_abnormal_salivary_gland0.69542425
151MP0003941_abnormal_skin_development0.69108059
152MP0009278_abnormal_bone_marrow0.67467844
153MP0002160_abnormal_reproductive_system0.64958840
154MP0005621_abnormal_cell_physiology0.63375012
155MP0002796_impaired_skin_barrier0.61148258
156MP0000678_abnormal_parathyroid_gland0.61024309
157MP0003787_abnormal_imprinting0.60992236

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)6.71317687
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.62869338
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.62869338
4CNS hypomyelination (HP:0003429)4.41517036
5Peripheral hypomyelination (HP:0007182)4.32336181
6Neurofibrillary tangles (HP:0002185)4.22569156
7Increased serum pyruvate (HP:0003542)4.22016971
8Abnormality of glycolysis (HP:0004366)4.22016971
9Abnormality of the corticospinal tract (HP:0002492)4.11359597
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.90090745
11Microvesicular hepatic steatosis (HP:0001414)3.83400329
12Chromsome breakage (HP:0040012)3.73605804
13Increased circulating renin level (HP:0000848)3.62743161
14Abnormal auditory evoked potentials (HP:0006958)3.54911524
15Sensory axonal neuropathy (HP:0003390)3.38377680
16Hypokalemic alkalosis (HP:0001949)3.35980109
17Type I transferrin isoform profile (HP:0003642)3.30465395
18Cerebral inclusion bodies (HP:0100314)3.27131601
19Spastic paraparesis (HP:0002313)3.25680680
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.19010667
21Abnormal protein N-linked glycosylation (HP:0012347)3.19010667
22Abnormal protein glycosylation (HP:0012346)3.19010667
23Abnormal glycosylation (HP:0012345)3.19010667
24Progressive muscle weakness (HP:0003323)3.17457036
25Metabolic alkalosis (HP:0200114)3.16668996
26Spastic gait (HP:0002064)3.15459537
27Hypomagnesemia (HP:0002917)3.08419918
28Pancreatic islet-cell hyperplasia (HP:0004510)3.07609064
29Hypoplastic pelvis (HP:0008839)3.05895463
30Onion bulb formation (HP:0003383)3.02608300
31Leukodystrophy (HP:0002415)2.92395147
32Hyperglycinuria (HP:0003108)2.92357199
33Septate vagina (HP:0001153)2.91132990
34Stridor (HP:0010307)2.86727804
35Parakeratosis (HP:0001036)2.84348564
36Postnatal microcephaly (HP:0005484)2.83492857
37Reduced antithrombin III activity (HP:0001976)2.79415931
38Morphological abnormality of the inner ear (HP:0011390)2.76615689
39Homocystinuria (HP:0002156)2.72540086
40Abnormality of homocysteine metabolism (HP:0010919)2.72540086
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.65503907
42Esophageal atresia (HP:0002032)2.63616750
43Abnormality of methionine metabolism (HP:0010901)2.55177260
44Progressive external ophthalmoplegia (HP:0000590)2.52517847
45Premature ovarian failure (HP:0008209)2.51668180
46Abnormality of the preputium (HP:0100587)2.49178061
47Abnormality of the pancreatic islet cells (HP:0006476)2.48748253
48Abnormality of endocrine pancreas physiology (HP:0012093)2.48748253
49Termporal pattern (HP:0011008)2.48317831
50Insidious onset (HP:0003587)2.48317831
51Alacrima (HP:0000522)2.48026800
52Myelodysplasia (HP:0002863)2.47525406
53Intention tremor (HP:0002080)2.46681289
54Abnormality of the salivary glands (HP:0010286)2.46553538
55Spastic tetraparesis (HP:0001285)2.45998770
56Birth length less than 3rd percentile (HP:0003561)2.45470935
57Abnormality of cells of the erythroid lineage (HP:0012130)2.44934507
58Anteriorly placed anus (HP:0001545)2.42974703
59Ependymoma (HP:0002888)2.39909720
60Intestinal fistula (HP:0100819)2.37094303
61Nephroblastoma (Wilms tumor) (HP:0002667)2.36883360
62Abnormality of magnesium homeostasis (HP:0004921)2.35710111
63Meckel diverticulum (HP:0002245)2.32908710
64Carpal bone hypoplasia (HP:0001498)2.31611450
65Retinal dysplasia (HP:0007973)2.30850193
66Premature skin wrinkling (HP:0100678)2.30192607
67Neoplasm of the oral cavity (HP:0100649)2.29778998
68Supranuclear gaze palsy (HP:0000605)2.29703892
69Abnormal number of erythroid precursors (HP:0012131)2.29310383
70Abnormality of the ileum (HP:0001549)2.27500897
71Macrocytic anemia (HP:0001972)2.26815926
72Breast hypoplasia (HP:0003187)2.26310540
73Renal salt wasting (HP:0000127)2.24734377
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22237047
75Impulsivity (HP:0100710)2.19534468
76Abnormality of glycine metabolism (HP:0010895)2.16549872
77Abnormality of serine family amino acid metabolism (HP:0010894)2.16549872
78Embryonal renal neoplasm (HP:0011794)2.16013185
79Polyuria (HP:0000103)2.15923485
80Duplicated collecting system (HP:0000081)2.15087449
81Dysmetria (HP:0001310)2.14348359
82Abnormal biliary tract physiology (HP:0012439)2.13947887
83Bile duct proliferation (HP:0001408)2.13947887
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.11476982
85Pancytopenia (HP:0001876)2.09430702
86Squamous cell carcinoma (HP:0002860)2.08528249
87Decreased lacrimation (HP:0000633)2.08441151
88Overlapping toe (HP:0001845)2.07993862
89Rough bone trabeculation (HP:0100670)2.06700815
90Asplenia (HP:0001746)2.06558034
91Ragged-red muscle fibers (HP:0003200)2.04863410
92Slow saccadic eye movements (HP:0000514)2.04691170
93Autoamputation (HP:0001218)2.04410393
94Sloping forehead (HP:0000340)2.04404869
95Abnormality of chromosome stability (HP:0003220)2.04307831
96Urinary urgency (HP:0000012)2.02745166
97Paraparesis (HP:0002385)2.01805690
98Polydipsia (HP:0001959)2.01511300
99Abnormal drinking behavior (HP:0030082)2.01511300
100Congenital ichthyosiform erythroderma (HP:0007431)2.01076238
101Testicular atrophy (HP:0000029)2.00911041
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00113456
103Ureteral duplication (HP:0000073)1.99762615
104Vaginal fistula (HP:0004320)1.97864510
105Partial agenesis of the corpus callosum (HP:0001338)1.97304822
106Multiple enchondromatosis (HP:0005701)1.97002841
107Abnormality of the astrocytes (HP:0100707)1.96724239
108Astrocytoma (HP:0009592)1.96724239
109Autoimmune hemolytic anemia (HP:0001890)1.94960638
110Dysmetric saccades (HP:0000641)1.94729643
111Delayed epiphyseal ossification (HP:0002663)1.94645058
112Stenosis of the external auditory canal (HP:0000402)1.94638633
113Choreoathetosis (HP:0001266)1.93895497
114Breast carcinoma (HP:0003002)1.93609785
115Cholecystitis (HP:0001082)1.93453566
116Abnormal gallbladder physiology (HP:0012438)1.93453566
117Prolonged partial thromboplastin time (HP:0003645)1.91995623
118Type II lissencephaly (HP:0007260)1.91752464
119Colon cancer (HP:0003003)1.90554813
120Sparse lateral eyebrow (HP:0005338)1.90461895
121Seborrheic dermatitis (HP:0001051)1.89523439
122Prominent occiput (HP:0000269)1.89207509
123Abnormality of DNA repair (HP:0003254)1.87666591
124Urethral obstruction (HP:0000796)1.87593202
125Severe combined immunodeficiency (HP:0004430)1.86181235
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.85982845
127Combined immunodeficiency (HP:0005387)1.85750892
128High anterior hairline (HP:0009890)1.84044490
129Abnormality of the umbilical cord (HP:0010881)1.83695252
130Abnormal urine output (HP:0012590)1.83563357
131Acute hepatic failure (HP:0006554)1.83083185
132Ankle clonus (HP:0011448)1.83037477
133Overriding aorta (HP:0002623)1.82962032
134Cafe-au-lait spot (HP:0000957)1.82949001
135Segmental peripheral demyelination/remyelination (HP:0003481)1.82892720
136Abnormality of serum amino acid levels (HP:0003112)1.82606759
137Absent septum pellucidum (HP:0001331)1.81910357
138Abnormality of the fingertips (HP:0001211)1.80221487
139Secondary amenorrhea (HP:0000869)1.80144753
140Embryonal neoplasm (HP:0002898)1.78618871
141Abnormality of T cell physiology (HP:0011840)1.78265787
142Scanning speech (HP:0002168)1.78126729
143Abnormal trabecular bone morphology (HP:0100671)1.77808589
144Rectal fistula (HP:0100590)1.77763019
145Rectovaginal fistula (HP:0000143)1.77763019
146Increased serum lactate (HP:0002151)1.77394267
147Hyperinsulinemic hypoglycemia (HP:0000825)1.77260299
148Abnormality of cochlea (HP:0000375)1.76977610
149Muscle fiber splitting (HP:0003555)1.76735698
150Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76561145
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.76435088
152Small epiphyses (HP:0010585)1.76308760
153Abnormality of the pons (HP:0007361)1.75251106
154Abnormality of the labia minora (HP:0012880)1.74629924
155Capillary hemangiomas (HP:0005306)1.73928607
156Clitoromegaly (HP:0000057)1.73667481
157IgM deficiency (HP:0002850)1.73472341
158Self-mutilation (HP:0000742)1.73368084
1593-Methylglutaconic aciduria (HP:0003535)1.72940822
160Glioma (HP:0009733)1.72438203
161Abnormality of the septum pellucidum (HP:0007375)1.72272277
162Amaurosis fugax (HP:0100576)1.71670304
163Clonus (HP:0002169)1.70921245
164Large earlobe (HP:0009748)1.70755214
165Type 2 muscle fiber atrophy (HP:0003554)1.70316508
166Enlarged kidneys (HP:0000105)1.69549949
167Renal Fanconi syndrome (HP:0001994)1.69434930
168Anal stenosis (HP:0002025)1.67386929
169Rhabdomyosarcoma (HP:0002859)1.65589882
170Emotional lability (HP:0000712)1.65433016
171Cerebellar dysplasia (HP:0007033)1.65272333
172Small intestinal stenosis (HP:0012848)1.65177669
173Duodenal stenosis (HP:0100867)1.65177669
174Diaphragmatic weakness (HP:0009113)1.65050622
175Bowel incontinence (HP:0002607)1.64649608
176Akinesia (HP:0002304)1.64380934
177Gout (HP:0001997)1.63270916
178Split foot (HP:0001839)1.63242099
179Hypoglycemic coma (HP:0001325)1.63170284
180Reticulocytosis (HP:0001923)1.63137424
181Muscle fiber atrophy (HP:0100295)1.63108806
182Abnormality of the renal collecting system (HP:0004742)1.62787184
183Hypergonadotropic hypogonadism (HP:0000815)1.62638486
184Prominent nose (HP:0000448)1.62413779
185Hypobetalipoproteinemia (HP:0003563)1.62160642
186Delusions (HP:0000746)1.59888162
187Abnormality of the fetal cardiovascular system (HP:0010948)1.58610756
188Abnormal umbilical cord blood vessels (HP:0011403)1.58610756
189Single umbilical artery (HP:0001195)1.58610756
190Morphological abnormality of the pyramidal tract (HP:0002062)1.58425603
191Megaloblastic anemia (HP:0001889)1.58263121
192External ophthalmoplegia (HP:0000544)1.57768812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.16359006
2OXSR14.56490845
3WNK43.44448387
4TESK23.00213946
5BUB12.77967994
6EPHB12.54955545
7WEE12.44355552
8CDK192.38841583
9PNCK2.37915826
10SMG12.32741143
11MAPKAPK52.20236035
12BRSK22.14057552
13MET2.08324298
14MAPKAPK31.98876160
15MAP3K101.98510261
16WNK11.86690360
17ZAK1.83446753
18LIMK11.75789112
19TYRO31.74858865
20CSNK1G31.70753941
21CDC71.69447299
22MKNK21.66874678
23TSSK61.65111078
24PKN11.64580628
25PBK1.61619860
26UHMK11.56828953
27VRK21.53069005
28ICK1.51001557
29CSNK1A1L1.46332752
30FGFR41.44853470
31MST41.43196184
32BCR1.41648452
33NUAK11.31804068
34WNK31.30253457
35TRIB31.28437972
36CSNK1G11.27678998
37CDK41.27498485
38TTK1.26688840
39MUSK1.26688703
40ROCK21.23247104
41MAP3K71.22998594
42PLK41.22107838
43CLK11.18970398
44PLK31.16270995
45IRAK31.14634533
46NEK61.14418105
47TRIM281.14027710
48MAPK111.08744068
49BRSK11.04414312
50TLK11.04336836
51DYRK31.03121934
52MKNK11.03079744
53STK161.01049131
54CSNK1G21.00169819
55EPHA30.99659184
56SRPK10.99136162
57NTRK10.99038342
58ALK0.95656523
59MAP3K140.95020939
60MAP4K20.94067776
61STK100.94004834
62ATM0.93386940
63CDK60.89699895
64SIK30.89609663
65MAP4K10.88363440
66PAK10.88088300
67MAP3K80.87929423
68EIF2AK10.87258656
69IRAK20.86492584
70EIF2AK20.84533872
71RPS6KA40.84524317
72ITK0.83084102
73DYRK20.82863284
74CDK70.80647343
75PAK20.79927570
76TAF10.78906648
77KSR20.78208363
78RPS6KB20.77660026
79EIF2AK30.77318904
80AURKB0.76624248
81SIK10.75496788
82NLK0.74909563
83CDK140.74802053
84BRD40.74665628
85AKT30.74439647
86CAMK2B0.74334243
87TRPM70.72390856
88JAK30.71744416
89CHEK10.71275941
90PAK60.71163993
91CSNK1E0.71085074
92FGFR20.69516308
93CDK90.67946859
94CSNK1D0.67930038
95MARK20.67928006
96CAMK1D0.67794955
97FGFR30.67036676
98RPS6KA50.66662742
99LRRK20.65739150
100CDK80.65346535
101DAPK10.64114260
102NEK20.63928749
103CDK120.62885047
104CDK150.62709538
105SCYL20.62629806
106EPHA20.61898842
107CDK11A0.60579976
108VRK10.59766945
109ACVR1B0.59258832
110AURKA0.58787198
111IKBKB0.58364575
112PDK20.57694163
113PASK0.57466935
114TXK0.56302600
115PRKAA10.55583624
116BCKDK0.54596145
117FGFR10.54318509
118GRK60.52880161
119PLK10.52209014
120CDK180.51707207
121RPS6KB10.51623834
122CSNK2A20.51462402
123GSK3A0.50551165
124FGR0.50478602
125EEF2K0.49893535
126PRPF4B0.47074452
127CHEK20.46174203
128CDK20.46012135
129PHKG20.45876838
130PHKG10.45876838
131TNIK0.45351871
132IRAK10.43298770
133MTOR0.42446539
134PRKAA20.42412949
135MELK0.42247844
136BMX0.41091266
137PAK40.41079312
138PRKCI0.40127000
139NME20.39605376
140CAMK2D0.39341997
141RAF10.38795038
142OBSCN0.38146535
143ATR0.36085934
144CDK10.35719686
145MAP3K130.35615669
146STK40.34252008
147PAK30.33771911
148CAMK2G0.33317689
149PDPK10.32856331
150NEK10.32327051
151NME10.30865302
152ERBB20.30225738
153MAPK100.30087059
154MAP2K20.30019084

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.87085833
2Fatty acid elongation_Homo sapiens_hsa000623.20318520
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.18286772
4Vitamin B6 metabolism_Homo sapiens_hsa007503.13646373
5Steroid biosynthesis_Homo sapiens_hsa001002.86994001
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83400416
7DNA replication_Homo sapiens_hsa030302.77593528
8Ribosome_Homo sapiens_hsa030102.72786103
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47743541
10Spliceosome_Homo sapiens_hsa030402.44182836
11* RNA polymerase_Homo sapiens_hsa030202.44133180
12Mismatch repair_Homo sapiens_hsa034302.40596858
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30493945
14Ether lipid metabolism_Homo sapiens_hsa005652.17141242
15Protein export_Homo sapiens_hsa030602.03736280
16RNA transport_Homo sapiens_hsa030132.01454790
17Proteasome_Homo sapiens_hsa030502.00568753
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.83161575
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82870245
20Homologous recombination_Homo sapiens_hsa034401.75544845
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68717990
22Basal transcription factors_Homo sapiens_hsa030221.66701194
23Non-homologous end-joining_Homo sapiens_hsa034501.64994704
24Nucleotide excision repair_Homo sapiens_hsa034201.64398789
25Folate biosynthesis_Homo sapiens_hsa007901.63788499
26Arginine and proline metabolism_Homo sapiens_hsa003301.59660769
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59232805
28Lysine degradation_Homo sapiens_hsa003101.50491851
29One carbon pool by folate_Homo sapiens_hsa006701.49358556
30Glutathione metabolism_Homo sapiens_hsa004801.43844422
31Linoleic acid metabolism_Homo sapiens_hsa005911.39717568
32Oxidative phosphorylation_Homo sapiens_hsa001901.33629152
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31806199
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27515831
35Biosynthesis of amino acids_Homo sapiens_hsa012301.25797280
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.24629864
37mRNA surveillance pathway_Homo sapiens_hsa030151.24174891
38* Pyrimidine metabolism_Homo sapiens_hsa002401.15933356
39Parkinsons disease_Homo sapiens_hsa050121.15628022
40Sphingolipid metabolism_Homo sapiens_hsa006001.15346487
41Nitrogen metabolism_Homo sapiens_hsa009101.14021026
42Cell cycle_Homo sapiens_hsa041101.13054871
43N-Glycan biosynthesis_Homo sapiens_hsa005101.11012797
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99606361
45Butanoate metabolism_Homo sapiens_hsa006500.98340659
46Pentose phosphate pathway_Homo sapiens_hsa000300.97184714
47Circadian rhythm_Homo sapiens_hsa047100.94787635
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90697420
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90566061
50Acute myeloid leukemia_Homo sapiens_hsa052210.90229490
51Base excision repair_Homo sapiens_hsa034100.88170362
52Sulfur relay system_Homo sapiens_hsa041220.87602987
53RNA degradation_Homo sapiens_hsa030180.87479709
54Arginine biosynthesis_Homo sapiens_hsa002200.84616109
55Selenocompound metabolism_Homo sapiens_hsa004500.83873050
56mTOR signaling pathway_Homo sapiens_hsa041500.83387265
57Thyroid cancer_Homo sapiens_hsa052160.79678846
58Axon guidance_Homo sapiens_hsa043600.77266539
59Tight junction_Homo sapiens_hsa045300.76698150
60Huntingtons disease_Homo sapiens_hsa050160.76101680
61Primary immunodeficiency_Homo sapiens_hsa053400.75957663
62T cell receptor signaling pathway_Homo sapiens_hsa046600.75870055
63Histidine metabolism_Homo sapiens_hsa003400.74723403
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73831108
65Fructose and mannose metabolism_Homo sapiens_hsa000510.72603255
66* Purine metabolism_Homo sapiens_hsa002300.70731994
67Pyruvate metabolism_Homo sapiens_hsa006200.68219245
68Renal cell carcinoma_Homo sapiens_hsa052110.66322275
69Vitamin digestion and absorption_Homo sapiens_hsa049770.65319600
70Metabolic pathways_Homo sapiens_hsa011000.63388644
71Herpes simplex infection_Homo sapiens_hsa051680.61110956
72Alzheimers disease_Homo sapiens_hsa050100.60543134
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60378492
74p53 signaling pathway_Homo sapiens_hsa041150.59726553
75Hedgehog signaling pathway_Homo sapiens_hsa043400.59554968
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.58940236
77Fanconi anemia pathway_Homo sapiens_hsa034600.58449902
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58234654
79Carbon metabolism_Homo sapiens_hsa012000.58113973
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57628419
81Non-small cell lung cancer_Homo sapiens_hsa052230.57386237
82Propanoate metabolism_Homo sapiens_hsa006400.55788024
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.55065891
84Arachidonic acid metabolism_Homo sapiens_hsa005900.54695285
85Systemic lupus erythematosus_Homo sapiens_hsa053220.52685711
86AMPK signaling pathway_Homo sapiens_hsa041520.52443999
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52089285
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.51894268
89Endocytosis_Homo sapiens_hsa041440.50092978
90* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50076834
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49978458
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49260394
93Oocyte meiosis_Homo sapiens_hsa041140.49094418
94Chronic myeloid leukemia_Homo sapiens_hsa052200.47074434
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45572247
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44472117
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44296554
98Sulfur metabolism_Homo sapiens_hsa009200.43131661
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.43060682
100Alcoholism_Homo sapiens_hsa050340.42992007
101Fatty acid biosynthesis_Homo sapiens_hsa000610.42602982
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41596257
103Prostate cancer_Homo sapiens_hsa052150.41544773
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40994644
105Viral carcinogenesis_Homo sapiens_hsa052030.40682653
106Colorectal cancer_Homo sapiens_hsa052100.40647411
107Insulin signaling pathway_Homo sapiens_hsa049100.40241736
108HTLV-I infection_Homo sapiens_hsa051660.40116309
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39285926
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.39087383
111Insulin resistance_Homo sapiens_hsa049310.38485578
112Basal cell carcinoma_Homo sapiens_hsa052170.36993438
113Hippo signaling pathway_Homo sapiens_hsa043900.36797452
114Glucagon signaling pathway_Homo sapiens_hsa049220.35832008
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34937379
116* Epstein-Barr virus infection_Homo sapiens_hsa051690.34821748
117Cardiac muscle contraction_Homo sapiens_hsa042600.34067176
118Other glycan degradation_Homo sapiens_hsa005110.34026727
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.32610707
120Hepatitis B_Homo sapiens_hsa051610.31175899
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29890057
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29413462
123Measles_Homo sapiens_hsa051620.28934435
124Fat digestion and absorption_Homo sapiens_hsa049750.27379143
125Peroxisome_Homo sapiens_hsa041460.26448984
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26284996
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25786848
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21497191
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19263602
130Collecting duct acid secretion_Homo sapiens_hsa049660.17899267
131Protein digestion and absorption_Homo sapiens_hsa049740.17495133
132Inositol phosphate metabolism_Homo sapiens_hsa005620.16872420
133Shigellosis_Homo sapiens_hsa051310.16815812
134Glycerolipid metabolism_Homo sapiens_hsa005610.15874830
135MicroRNAs in cancer_Homo sapiens_hsa052060.15291128
136Fatty acid metabolism_Homo sapiens_hsa012120.14920570
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14239551
138beta-Alanine metabolism_Homo sapiens_hsa004100.14203280
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13567595

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