POLR3F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CENP-A containing nucleosome assembly (GO:0034080)4.68581231
2chromatin remodeling at centromere (GO:0031055)4.64714979
3cullin deneddylation (GO:0010388)4.55440482
4kinetochore organization (GO:0051383)4.47561803
5regulation of nuclear cell cycle DNA replication (GO:0033262)4.32401965
6regulation of DNA endoreduplication (GO:0032875)4.31045468
7IMP biosynthetic process (GO:0006188)4.20754261
8establishment of integrated proviral latency (GO:0075713)4.19967997
9DNA damage response, detection of DNA damage (GO:0042769)4.17964852
10protein deneddylation (GO:0000338)4.17578641
11DNA replication checkpoint (GO:0000076)4.14269115
12DNA replication-independent nucleosome organization (GO:0034724)4.12775063
13DNA replication-independent nucleosome assembly (GO:0006336)4.12775063
14kinetochore assembly (GO:0051382)4.10123789
15telomere maintenance via semi-conservative replication (GO:0032201)4.08608171
16negative regulation of DNA-dependent DNA replication (GO:2000104)4.07091858
17DNA replication initiation (GO:0006270)4.00293649
18proteasome assembly (GO:0043248)3.93047219
19mitotic recombination (GO:0006312)3.92105588
20telomere maintenance via recombination (GO:0000722)3.89393377
21DNA strand elongation involved in DNA replication (GO:0006271)3.84933821
22mitotic metaphase plate congression (GO:0007080)3.83755256
23histone exchange (GO:0043486)3.81723345
24protein K6-linked ubiquitination (GO:0085020)3.81077456
25nuclear pore organization (GO:0006999)3.73808289
26telomere maintenance via telomere lengthening (GO:0010833)3.72502735
27nucleobase biosynthetic process (GO:0046112)3.70789918
28DNA strand elongation (GO:0022616)3.68766640
29metaphase plate congression (GO:0051310)3.65519744
30meiotic chromosome segregation (GO:0045132)3.65499245
31purine nucleobase biosynthetic process (GO:0009113)3.61411505
32regulation of centriole replication (GO:0046599)3.58919163
33attachment of spindle microtubules to kinetochore (GO:0008608)3.58067080
34histone H2A acetylation (GO:0043968)3.57224637
35regulation of double-strand break repair via homologous recombination (GO:0010569)3.55101695
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.50020511
37nuclear pore complex assembly (GO:0051292)3.46156052
38maturation of 5.8S rRNA (GO:0000460)3.45878961
39intra-S DNA damage checkpoint (GO:0031573)3.45629401
40spindle checkpoint (GO:0031577)3.43130804
41IMP metabolic process (GO:0046040)3.37892210
42mitotic sister chromatid cohesion (GO:0007064)3.37229419
43spindle assembly checkpoint (GO:0071173)3.37212335
44establishment of viral latency (GO:0019043)3.36890797
45mismatch repair (GO:0006298)3.36342603
46negative regulation of mitotic sister chromatid separation (GO:2000816)3.33160161
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.33160161
48negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.33160161
49negative regulation of sister chromatid segregation (GO:0033046)3.33160161
50mitotic spindle assembly checkpoint (GO:0007094)3.30304866
51ribosome assembly (GO:0042255)3.29606382
52regulation of mitotic metaphase/anaphase transition (GO:0030071)3.26804847
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25670631
54regulation of mitotic spindle checkpoint (GO:1903504)3.25670631
55DNA unwinding involved in DNA replication (GO:0006268)3.24950843
56negative regulation of chromosome segregation (GO:0051985)3.22763628
57DNA strand renaturation (GO:0000733)3.22750937
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22348598
59DNA synthesis involved in DNA repair (GO:0000731)3.21389320
60establishment of chromosome localization (GO:0051303)3.21204917
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.20566997
62mitotic spindle checkpoint (GO:0071174)3.19158856
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18594897
64telomere maintenance via telomerase (GO:0007004)3.16629855
65telomere maintenance (GO:0000723)3.16376649
66respiratory chain complex IV assembly (GO:0008535)3.13240315
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12681569
68DNA-dependent DNA replication (GO:0006261)3.12515917
69regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.11870003
70double-strand break repair via nonhomologous end joining (GO:0006303)3.11563717
71non-recombinational repair (GO:0000726)3.11563717
72telomere organization (GO:0032200)3.11096990
73regulation of mitotic sister chromatid separation (GO:0010965)3.10667085
74regulation of mitotic sister chromatid segregation (GO:0033047)3.10667085
75regulation of sister chromatid segregation (GO:0033045)3.10667085
76DNA double-strand break processing (GO:0000729)3.10413008
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08610381
78chaperone-mediated protein transport (GO:0072321)3.06668212
79tRNA methylation (GO:0030488)3.06164960
80microtubule depolymerization (GO:0007019)3.06051184
81regulation of spindle organization (GO:0090224)3.05250812
82protein localization to kinetochore (GO:0034501)3.03749536
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03180745
84mitotic sister chromatid segregation (GO:0000070)3.02683402
85transcription elongation from RNA polymerase I promoter (GO:0006362)3.01993234
86postreplication repair (GO:0006301)3.00837112
87DNA replication-dependent nucleosome assembly (GO:0006335)2.99469154
88DNA replication-dependent nucleosome organization (GO:0034723)2.99469154
89mitotic nuclear envelope disassembly (GO:0007077)2.98949523
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98758071
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97732618
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96955807
93sister chromatid cohesion (GO:0007062)2.95689271
94replication fork processing (GO:0031297)2.94664969
95regulation of centrosome cycle (GO:0046605)2.92837350
96termination of RNA polymerase I transcription (GO:0006363)2.89514839
97sister chromatid segregation (GO:0000819)2.89461997
98regulation of chromosome segregation (GO:0051983)2.87950755
99synapsis (GO:0007129)2.87940472
100regulation of meiosis I (GO:0060631)2.87631691
101spliceosomal snRNP assembly (GO:0000387)2.87313853
102ATP-dependent chromatin remodeling (GO:0043044)2.86874477
103ribosome biogenesis (GO:0042254)2.86348550
104chromosome segregation (GO:0007059)2.85646498
105reciprocal meiotic recombination (GO:0007131)2.84659460
106reciprocal DNA recombination (GO:0035825)2.84659460
107positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83849543
108regulation of DNA-dependent DNA replication (GO:0090329)2.83383702
109DNA topological change (GO:0006265)2.82913278
110mitotic chromosome condensation (GO:0007076)2.82875121
111RNA-dependent DNA replication (GO:0006278)2.82325208
112ribosomal large subunit biogenesis (GO:0042273)2.81672663
113anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80839642
114protein localization to chromosome, centromeric region (GO:0071459)2.80491852
115centriole replication (GO:0007099)2.80465605
116mitochondrial RNA metabolic process (GO:0000959)2.78439008
117chromatin assembly or disassembly (GO:0006333)2.75506238
118histone mRNA metabolic process (GO:0008334)2.75416492
119RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75322453
120pore complex assembly (GO:0046931)2.75160975
121* termination of RNA polymerase III transcription (GO:0006386)2.74982731
122* transcription elongation from RNA polymerase III promoter (GO:0006385)2.74982731
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74861847
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.74861847
125DNA replication (GO:0006260)2.74567468
126rRNA modification (GO:0000154)2.73760183
127DNA duplex unwinding (GO:0032508)2.73367765
128negative regulation of mitosis (GO:0045839)2.73332190
129transcription-coupled nucleotide-excision repair (GO:0006283)2.73254150
130protein heterotetramerization (GO:0051290)2.72965161
131protein neddylation (GO:0045116)2.71940438
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71756611
133negative regulation of ligase activity (GO:0051352)2.71756611
134DNA geometric change (GO:0032392)2.71720727
135negative regulation of DNA recombination (GO:0045910)2.71590138
136formation of translation preinitiation complex (GO:0001731)2.71538486
137signal peptide processing (GO:0006465)2.71137171
138transcription from mitochondrial promoter (GO:0006390)2.70345255
139regulation of mitochondrial translation (GO:0070129)2.67648399
140rRNA methylation (GO:0031167)2.63646845
141response to X-ray (GO:0010165)2.61914778
142tRNA aminoacylation for protein translation (GO:0006418)2.61187515
143amino acid activation (GO:0043038)2.58613424
144tRNA aminoacylation (GO:0043039)2.58613424
145protein localization to mitochondrion (GO:0070585)2.54031762
1467-methylguanosine mRNA capping (GO:0006370)2.51452362
147protein targeting to mitochondrion (GO:0006626)2.48915435
148anterograde synaptic vesicle transport (GO:0048490)2.47983928
149regulation of helicase activity (GO:0051095)2.47738917
150mitochondrial respiratory chain complex assembly (GO:0033108)2.47183974
151protein-cofactor linkage (GO:0018065)2.47144612
152cytochrome complex assembly (GO:0017004)2.45691071
153transcription elongation from RNA polymerase II promoter (GO:0006368)2.44957389
154DNA ligation (GO:0006266)2.44151897
155positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.43834220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.68527061
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.15251861
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.55706105
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29591334
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15438276
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97690015
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.96852932
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.81916692
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81143465
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.56134899
11ZNF274_21170338_ChIP-Seq_K562_Hela2.51548258
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43980742
13* EST1_17652178_ChIP-ChIP_JURKAT_Human2.42224544
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.26230268
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.17397115
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16474639
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16116328
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15982357
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.15643824
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14772843
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14369181
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13183114
23ELK1_19687146_ChIP-ChIP_HELA_Human2.12047091
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11102142
25TP63_19390658_ChIP-ChIP_HaCaT_Human2.09816713
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04094215
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03625167
28VDR_23849224_ChIP-Seq_CD4+_Human2.03017425
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00356463
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98781356
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97413675
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97222340
33IGF1R_20145208_ChIP-Seq_DFB_Human1.95917509
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94155924
35FOXP3_21729870_ChIP-Seq_TREG_Human1.90537755
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88352828
37* ETS1_20019798_ChIP-Seq_JURKAT_Human1.84708711
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78047832
39EWS_26573619_Chip-Seq_HEK293_Human1.76969037
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76387514
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73133716
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.69254342
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69135084
44TAF15_26573619_Chip-Seq_HEK293_Human1.60725007
45AR_21909140_ChIP-Seq_LNCAP_Human1.60658838
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.59998943
47* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56731955
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54031180
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.53082571
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48408504
51FUS_26573619_Chip-Seq_HEK293_Human1.47749103
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42572871
53P300_19829295_ChIP-Seq_ESCs_Human1.42403191
54TTF2_22483619_ChIP-Seq_HELA_Human1.41334334
55* DCP1A_22483619_ChIP-Seq_HELA_Human1.37720634
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37647916
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34402638
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.33946173
59XRN2_22483619_ChIP-Seq_HELA_Human1.33522337
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31293052
61MYC_18940864_ChIP-ChIP_HL60_Human1.30954225
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30510301
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26652774
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24281909
65GABP_19822575_ChIP-Seq_HepG2_Human1.23353805
66CIITA_25753668_ChIP-Seq_RAJI_Human1.21695216
67VDR_22108803_ChIP-Seq_LS180_Human1.21154036
68GBX2_23144817_ChIP-Seq_PC3_Human1.19798890
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18892994
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18281545
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15511463
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.12515774
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12467051
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10566327
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10053000
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09292757
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09275225
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08586042
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07779211
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06770045
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05760510
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04599180
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03568647
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01521245
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01341158
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.00450696
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00014505
88CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99898961
89IRF1_19129219_ChIP-ChIP_H3396_Human0.98875604
90NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97790068
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.96743929
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95885769
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95788859
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95018786
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94956995
96YY1_21170310_ChIP-Seq_MESCs_Mouse0.94795761
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94314216
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.93863360
99KDM5A_27292631_Chip-Seq_BREAST_Human0.93664614
100ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92893682
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.90262772
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89670494
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88853271
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88119744
105E2F1_18555785_Chip-Seq_ESCs_Mouse0.88092613
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87476678
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87080102
108NMYC_18555785_Chip-Seq_ESCs_Mouse0.86779427
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86154962
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.86017085
111FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85932272
112TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85735873
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85662436
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85041157
115STAT3_18555785_Chip-Seq_ESCs_Mouse0.84927177
116RNF2_27304074_Chip-Seq_NSC_Mouse0.84158496
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83902389
118* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82986987
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81685286
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80656012
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79939506
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.79715018
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79191590
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78781319
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78479713
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78261573
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78024583
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77787572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.39323102
2MP0003111_abnormal_nucleus_morphology4.09195131
3MP0003693_abnormal_embryo_hatching3.95789054
4MP0008058_abnormal_DNA_repair3.86417832
5MP0008877_abnormal_DNA_methylation3.55504999
6MP0006292_abnormal_olfactory_placode3.44197921
7MP0008057_abnormal_DNA_replication3.19256647
8MP0001188_hyperpigmentation3.02176823
9MP0003077_abnormal_cell_cycle3.01450420
10MP0001529_abnormal_vocalization2.97211630
11MP0008007_abnormal_cellular_replicative2.81730551
12MP0003880_abnormal_central_pattern2.61694525
13MP0004957_abnormal_blastocyst_morpholog2.57930625
14MP0002396_abnormal_hematopoietic_system2.41288569
15MP0003786_premature_aging2.12706191
16MP0003787_abnormal_imprinting2.11958536
17MP0003941_abnormal_skin_development2.04867129
18MP0008932_abnormal_embryonic_tissue2.01433840
19MP0003121_genomic_imprinting1.99524602
20MP0003123_paternal_imprinting1.97770213
21MP0000015_abnormal_ear_pigmentation1.91142415
22MP0003122_maternal_imprinting1.89567492
23MP0005394_taste/olfaction_phenotype1.76696955
24MP0005499_abnormal_olfactory_system1.76696955
25MP0001984_abnormal_olfaction1.76617036
26MP0002009_preneoplasia1.73231234
27MP0000566_synostosis1.69540778
28MP0002233_abnormal_nose_morphology1.66597900
29MP0002095_abnormal_skin_pigmentation1.62183007
30MP0002102_abnormal_ear_morphology1.60750873
31MP0000350_abnormal_cell_proliferation1.57658004
32MP0003890_abnormal_embryonic-extraembry1.53863240
33MP0005171_absent_coat_pigmentation1.51662835
34MP0010307_abnormal_tumor_latency1.50290573
35MP0009697_abnormal_copulation1.50173508
36MP0001293_anophthalmia1.42890848
37MP0003763_abnormal_thymus_physiology1.40801761
38MP0003718_maternal_effect1.36626754
39MP0002160_abnormal_reproductive_system1.34025734
40MP0003567_abnormal_fetal_cardiomyocyte1.32791484
41MP0006276_abnormal_autonomic_nervous1.31312091
42MP0009672_abnormal_birth_weight1.31091201
43MP0002938_white_spotting1.27533995
44MP0000778_abnormal_nervous_system1.27367332
45MP0002210_abnormal_sex_determination1.26822555
46MP0003136_yellow_coat_color1.26038435
47MP0005389_reproductive_system_phenotype1.23628880
48MP0001919_abnormal_reproductive_system1.22706065
49MP0000490_abnormal_crypts_of1.22703482
50MP0002163_abnormal_gland_morphology1.21555933
51MP0009046_muscle_twitch1.19561452
52MP0001672_abnormal_embryogenesis/_devel1.18685572
53MP0005380_embryogenesis_phenotype1.18685572
54MP0001119_abnormal_female_reproductive1.18262043
55MP0001730_embryonic_growth_arrest1.17667574
56MP0004808_abnormal_hematopoietic_stem1.17626473
57MP0005503_abnormal_tendon_morphology1.16820654
58MP0005423_abnormal_somatic_nervous1.11748961
59MP0001286_abnormal_eye_development1.11460970
60MP0004147_increased_porphyrin_level1.11236507
61MP0005174_abnormal_tail_pigmentation1.10489887
62MP0005379_endocrine/exocrine_gland_phen1.09060215
63MP0000631_abnormal_neuroendocrine_gland1.08044788
64MP0003937_abnormal_limbs/digits/tail_de1.07680774
65MP0001186_pigmentation_phenotype1.07537760
66MP0005253_abnormal_eye_physiology1.07386258
67MP0000516_abnormal_urinary_system1.06984257
68MP0005367_renal/urinary_system_phenotyp1.06984257
69MP0006035_abnormal_mitochondrial_morpho1.05763918
70MP0002132_abnormal_respiratory_system1.05346521
71MP0002085_abnormal_embryonic_tissue1.03497517
72MP0005187_abnormal_penis_morphology1.03158503
73MP0005551_abnormal_eye_electrophysiolog1.01745948
74MP0004270_analgesia1.01504079
75MP0002075_abnormal_coat/hair_pigmentati1.00405811
76MP0009780_abnormal_chondrocyte_physiolo0.99874327
77MP0003984_embryonic_growth_retardation0.99866535
78MP0001145_abnormal_male_reproductive0.99153226
79MP0000569_abnormal_digit_pigmentation0.98442026
80MP0005075_abnormal_melanosome_morpholog0.98416654
81MP0003186_abnormal_redox_activity0.97075318
82MP0002088_abnormal_embryonic_growth/wei0.96686235
83MP0000313_abnormal_cell_death0.96145625
84MP0001929_abnormal_gametogenesis0.95849015
85MP0001697_abnormal_embryo_size0.95809151
86MP0002184_abnormal_innervation0.95132585
87MP0001177_atelectasis0.94943242
88MP0000703_abnormal_thymus_morphology0.94939006
89MP0001299_abnormal_eye_distance/0.94614687
90MP0000647_abnormal_sebaceous_gland0.94206998
91MP0000653_abnormal_sex_gland0.94172141
92MP0003861_abnormal_nervous_system0.92217653
93MP0003315_abnormal_perineum_morphology0.91976510
94MP0002084_abnormal_developmental_patter0.91663451
95MP0005671_abnormal_response_to0.90870033
96MP0009745_abnormal_behavioral_response0.90367577
97MP0002234_abnormal_pharynx_morphology0.89661723
98MP0004811_abnormal_neuron_physiology0.89585032
99MP0003698_abnormal_male_reproductive0.86603406
100MP0002080_prenatal_lethality0.86092038
101MP0004197_abnormal_fetal_growth/weight/0.84922738
102MP0000383_abnormal_hair_follicle0.83885466
103MP0005408_hypopigmentation0.81952364
104MP0002019_abnormal_tumor_incidence0.81424883
105MP0000358_abnormal_cell_content/0.81303038
106MP0009703_decreased_birth_body0.78578046
107MP0000432_abnormal_head_morphology0.78437354
108MP0002638_abnormal_pupillary_reflex0.78312991
109MP0005386_behavior/neurological_phenoty0.78278473
110MP0004924_abnormal_behavior0.78278473
111MP0003011_delayed_dark_adaptation0.78132104
112MP0005084_abnormal_gallbladder_morpholo0.78063170
113MP0003221_abnormal_cardiomyocyte_apopto0.77403063
114MP0002177_abnormal_outer_ear0.77163130
115MP0003119_abnormal_digestive_system0.76676315
116MP0005195_abnormal_posterior_eye0.76470579
117MP0008789_abnormal_olfactory_epithelium0.76450450
118MP0010030_abnormal_orbit_morphology0.76146739
119MP0000955_abnormal_spinal_cord0.76011848
120MP0000372_irregular_coat_pigmentation0.75913113
121MP0009333_abnormal_splenocyte_physiolog0.75443772
122MP0002272_abnormal_nervous_system0.75292200
123MP0002090_abnormal_vision0.74527905
124MP0000049_abnormal_middle_ear0.74524842
125MP0001486_abnormal_startle_reflex0.74159908
126MP0002086_abnormal_extraembryonic_tissu0.74149783
127MP0002092_abnormal_eye_morphology0.73855070
128MP0003943_abnormal_hepatobiliary_system0.72663205
129MP0006072_abnormal_retinal_apoptosis0.72387381
130MP0003942_abnormal_urinary_system0.72380863
131MP0004381_abnormal_hair_follicle0.71426776
132MP0000428_abnormal_craniofacial_morphol0.71323595
133MP0005391_vision/eye_phenotype0.69395612
134MP0002398_abnormal_bone_marrow0.69165589
135MP0003935_abnormal_craniofacial_develop0.69084043
136MP0003755_abnormal_palate_morphology0.68432410
137MP0002877_abnormal_melanocyte_morpholog0.67447542
138MP0002111_abnormal_tail_morphology0.66388802
139MP0008260_abnormal_autophagy0.66360179
140MP0000427_abnormal_hair_cycle0.63202430
141MP0005409_darkened_coat_color0.62940448
142MP0002109_abnormal_limb_morphology0.61147683
143MP0002116_abnormal_craniofacial_bone0.60844635
144MP0002928_abnormal_bile_duct0.60744604
145MP0002751_abnormal_autonomic_nervous0.60741874
146MP0002697_abnormal_eye_size0.60728280

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.44324493
2Chromsome breakage (HP:0040012)5.27235885
3Birth length less than 3rd percentile (HP:0003561)4.84194752
4Abnormality of chromosome stability (HP:0003220)3.54104556
5Abnormality of the preputium (HP:0100587)3.38264487
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.36416886
7Meckel diverticulum (HP:0002245)3.34203210
8Acute necrotizing encephalopathy (HP:0006965)3.13231881
9Abnormality of the ileum (HP:0001549)3.10808906
10Ectopic kidney (HP:0000086)3.10052041
11Volvulus (HP:0002580)2.98307748
12Acute encephalopathy (HP:0006846)2.92196019
13Duplicated collecting system (HP:0000081)2.88933692
14Progressive macrocephaly (HP:0004481)2.85423347
15Abnormality of the renal collecting system (HP:0004742)2.82089328
16Intestinal atresia (HP:0011100)2.80324506
17Increased hepatocellular lipid droplets (HP:0006565)2.78183031
18Patellar aplasia (HP:0006443)2.68292503
19Abnormal mitochondria in muscle tissue (HP:0008316)2.67677824
20Increased CSF lactate (HP:0002490)2.66686687
21Duodenal stenosis (HP:0100867)2.64103365
22Small intestinal stenosis (HP:0012848)2.64103365
23Breast hypoplasia (HP:0003187)2.63502730
24Aplastic anemia (HP:0001915)2.59856361
25Myelodysplasia (HP:0002863)2.54667342
26Abnormality of the labia minora (HP:0012880)2.52620492
27Mitochondrial inheritance (HP:0001427)2.51099817
28Bone marrow hypocellularity (HP:0005528)2.47084213
29Aplasia/Hypoplasia of the patella (HP:0006498)2.45820130
30Abnormality of DNA repair (HP:0003254)2.42516240
31Lipid accumulation in hepatocytes (HP:0006561)2.40948389
32Abnormal lung lobation (HP:0002101)2.40725822
33Nephroblastoma (Wilms tumor) (HP:0002667)2.40251408
34Embryonal renal neoplasm (HP:0011794)2.39258645
35Impulsivity (HP:0100710)2.38903586
36Abnormality of the duodenum (HP:0002246)2.38269148
37Clubbing of toes (HP:0100760)2.37731242
38Type I transferrin isoform profile (HP:0003642)2.34022467
39Supernumerary spleens (HP:0009799)2.31132545
40True hermaphroditism (HP:0010459)2.27760549
41Abnormality of the carotid arteries (HP:0005344)2.26051139
42Medulloblastoma (HP:0002885)2.22593175
43Hepatocellular necrosis (HP:0001404)2.22300597
44Prostate neoplasm (HP:0100787)2.19633605
45Colon cancer (HP:0003003)2.18587487
46Pancreatic fibrosis (HP:0100732)2.18280854
47Abnormality of the anterior horn cell (HP:0006802)2.17831210
48Degeneration of anterior horn cells (HP:0002398)2.17831210
49Absent radius (HP:0003974)2.17493344
50Sloping forehead (HP:0000340)2.16782455
51Bifid tongue (HP:0010297)2.11554246
52Aplasia/Hypoplasia of the earlobes (HP:0009906)2.10931443
53Abnormal number of incisors (HP:0011064)2.10599064
54Lissencephaly (HP:0001339)2.09455039
55Neoplasm of the adrenal gland (HP:0100631)2.06883313
56Hyperglycinemia (HP:0002154)2.05730527
57Nephronophthisis (HP:0000090)2.04419814
58Cortical dysplasia (HP:0002539)2.04359357
59Triphalangeal thumb (HP:0001199)2.04300423
60Increased serum lactate (HP:0002151)2.03384306
61Stenosis of the external auditory canal (HP:0000402)2.01869857
62Absent forearm bone (HP:0003953)2.01275473
63Aplasia involving forearm bones (HP:0009822)2.01275473
64Abnormal hair whorl (HP:0010721)2.00506281
65Facial cleft (HP:0002006)2.00331978
66Ependymoma (HP:0002888)1.97840046
67Amyotrophic lateral sclerosis (HP:0007354)1.97393326
68Increased serum pyruvate (HP:0003542)1.96356292
69Microvesicular hepatic steatosis (HP:0001414)1.96074704
70Hepatic necrosis (HP:0002605)1.95887173
71Pancreatic cysts (HP:0001737)1.95600713
72Stomach cancer (HP:0012126)1.93805291
73Cerebral edema (HP:0002181)1.93541935
74Short thumb (HP:0009778)1.91025915
75Atrophy/Degeneration involving motor neurons (HP:0007373)1.91021236
76Preaxial hand polydactyly (HP:0001177)1.90593325
77Papillary thyroid carcinoma (HP:0002895)1.88486924
78Reticulocytopenia (HP:0001896)1.88296070
79Abnormality of glycolysis (HP:0004366)1.87993548
80Cerebral hypomyelination (HP:0006808)1.87892008
81Pelvic girdle muscle weakness (HP:0003749)1.87852777
82Molar tooth sign on MRI (HP:0002419)1.86463742
83Abnormality of midbrain morphology (HP:0002418)1.86463742
84Pancreatic islet-cell hyperplasia (HP:0004510)1.86058764
85Agnosia (HP:0010524)1.85905226
86Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85518588
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85518588
88Abnormal spermatogenesis (HP:0008669)1.85192332
89Pendular nystagmus (HP:0012043)1.83419270
90Horseshoe kidney (HP:0000085)1.81993228
91Acute myeloid leukemia (HP:0004808)1.81854224
92Neuroendocrine neoplasm (HP:0100634)1.81673151
93Hepatoblastoma (HP:0002884)1.81104636
94Leukodystrophy (HP:0002415)1.80456103
95Lactic acidosis (HP:0003128)1.79103861
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.77670406
97Retinal dysplasia (HP:0007973)1.77641253
98Optic nerve hypoplasia (HP:0000609)1.76627572
99Abnormality of the columella (HP:0009929)1.76538311
100Deep philtrum (HP:0002002)1.76459348
101Lymphoma (HP:0002665)1.76369366
102Pheochromocytoma (HP:0002666)1.76279168
103Premature graying of hair (HP:0002216)1.75734379
104Selective tooth agenesis (HP:0001592)1.74677630
105Oral leukoplakia (HP:0002745)1.74629089
106Cellular immunodeficiency (HP:0005374)1.74470851
107Optic disc pallor (HP:0000543)1.74385735
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74090819
109Neoplasm of the small intestine (HP:0100833)1.73046819
110Tubulointerstitial nephritis (HP:0001970)1.72840602
111Alveolar cell carcinoma (HP:0006519)1.72562175
112Renal Fanconi syndrome (HP:0001994)1.72436073
113Abnormality of the incisor (HP:0000676)1.72195004
114Slender long bone (HP:0003100)1.71948324
115Nephrogenic diabetes insipidus (HP:0009806)1.70703861
116Thyroid carcinoma (HP:0002890)1.70437167
117Gonadotropin excess (HP:0000837)1.69750322
118Neoplasm of the adrenal cortex (HP:0100641)1.67582068
119Absent thumb (HP:0009777)1.67552331
120Type II lissencephaly (HP:0007260)1.67358163
121Impaired vibration sensation in the lower limbs (HP:0002166)1.66764251
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.66645378
123Shoulder girdle muscle weakness (HP:0003547)1.66023501
124Neoplasm of the colon (HP:0100273)1.65967110
125Gastrointestinal atresia (HP:0002589)1.65425036
126Sclerocornea (HP:0000647)1.65288838
127Myokymia (HP:0002411)1.64866016
128Abnormality of the hip-girdle musculature (HP:0001445)1.64862038
129Abnormality of the musculature of the pelvis (HP:0001469)1.64862038
130Hypoglycemic coma (HP:0001325)1.64831307
131Breast carcinoma (HP:0003002)1.64269131
132Glioma (HP:0009733)1.63847910
133Neoplasm of the peripheral nervous system (HP:0100007)1.63738316
134Tracheoesophageal fistula (HP:0002575)1.63608327
135Methylmalonic acidemia (HP:0002912)1.63540284
136Duplication of thumb phalanx (HP:0009942)1.62875161
137Abnormality of the metopic suture (HP:0005556)1.62701773
138Optic nerve coloboma (HP:0000588)1.62248722
139Oligohydramnios (HP:0001562)1.62166785
140Abnormality of alanine metabolism (HP:0010916)1.61777926
141Hyperalaninemia (HP:0003348)1.61777926
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61777926
143Horizontal nystagmus (HP:0000666)1.61677537
144Gaze-evoked nystagmus (HP:0000640)1.61341121
145Prominent metopic ridge (HP:0005487)1.61262395
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61029241
147Entropion (HP:0000621)1.61020048
148Short tibia (HP:0005736)1.60360122
149Adrenal hypoplasia (HP:0000835)1.59950192
150Astrocytoma (HP:0009592)1.59925078
151Abnormality of the astrocytes (HP:0100707)1.59925078
152Neoplasm of the pancreas (HP:0002894)1.59741493
153Increased nuchal translucency (HP:0010880)1.59236108
154Astigmatism (HP:0000483)1.57954045
15511 pairs of ribs (HP:0000878)1.56875207
156Neoplasm of the tracheobronchial system (HP:0100552)1.55892631
157Proximal placement of thumb (HP:0009623)1.55095618
158Severe visual impairment (HP:0001141)1.54775222
159Medial flaring of the eyebrow (HP:0010747)1.54450574
160Long eyelashes (HP:0000527)1.54010811
161Capillary hemangiomas (HP:0005306)1.53736908
162Rhabdomyosarcoma (HP:0002859)1.53155211
163Abnormal protein glycosylation (HP:0012346)1.53057193
164Abnormal glycosylation (HP:0012345)1.53057193
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.53057193
166Abnormal protein N-linked glycosylation (HP:0012347)1.53057193
167Aplasia/Hypoplasia of the fovea (HP:0008060)1.52906768
168Hypoplasia of the fovea (HP:0007750)1.52906768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.62369962
2CDC73.35242013
3SRPK13.25514966
4PLK43.15869884
5STK163.13634756
6TRIM283.00219398
7ACVR1B2.99244253
8BUB12.87113278
9MKNK22.69740214
10MKNK12.67488780
11EIF2AK12.62204278
12WEE12.45919738
13CASK2.19639057
14PNCK2.17247533
15BCR2.16911423
16MST42.10948349
17PLK31.99972064
18VRK11.94510917
19AKT31.91318564
20ATR1.90904235
21TSSK61.89400690
22TTK1.87687559
23EIF2AK31.83433569
24BRSK21.73756333
25PLK11.71158477
26CDK191.70862308
27ERBB31.70372487
28PASK1.64954900
29EIF2AK21.61249236
30YES11.60581156
31PBK1.59440066
32NEK21.55047447
33MAP3K41.54928412
34MAP4K21.53727003
35TAF11.50653472
36MARK11.50289160
37TLK11.48238812
38IRAK41.44315181
39CCNB11.41883204
40TXK1.41245809
41VRK21.37708647
42STK38L1.37706524
43SIK31.29702327
44MINK11.29586222
45NEK61.28655422
46AURKB1.28282965
47CSNK1G11.26538448
48CHEK21.20179621
49TEC1.13941221
50BRD41.12168429
51IRAK31.09549116
52PLK21.06108278
53ERBB41.04690871
54CHEK11.04668994
55INSRR1.04070407
56SGK21.02921016
57CDK31.01626578
58TNIK1.01259445
59CDK40.99556884
60DYRK30.99271295
61ATM0.98609601
62IRAK10.96664414
63NUAK10.96274595
64CSNK1G20.94388906
65CDK80.93080233
66CSNK1G30.92866055
67CDK70.89266661
68PAK30.88406576
69DYRK20.86216559
70CSNK1A1L0.85088127
71MELK0.81156701
72CLK10.79165976
73NME10.78892957
74LIMK10.77967727
75NTRK30.77032288
76PRKCG0.73651736
77IRAK20.73466966
78MAP2K70.72586969
79BMPR20.70384028
80TGFBR10.69647170
81STK40.69403938
82AURKA0.69378612
83BMPR1B0.67238593
84LATS10.66994963
85CDK20.66818423
86PIM10.65526963
87CDK10.64730650
88FLT30.64437874
89BRSK10.63961794
90BRAF0.62521662
91RPS6KA40.61260722
92EPHA40.61025630
93PHKG10.60889200
94PHKG20.60889200
95RPS6KB20.60880219
96RPS6KB10.60047575
97NLK0.60040828
98NEK90.59945035
99MAP3K140.59671087
100MAPK130.59663400
101PINK10.57587031
102CSNK1E0.54749137
103WNK30.54502679
104NME20.54352786
105CAMK1G0.54288397
106RPS6KA50.52576821
107CSNK2A20.51228462
108GRK70.51194437
109KSR10.48848443
110EPHA30.47827332
111SCYL20.47544738
112CSNK2A10.46165967
113STK240.46143832
114SGK30.45305202
115CDK120.45099033
116EPHA20.44862015
117CAMKK20.44551117
118TRPM70.44510265
119NEK10.43392967
120PDK20.43026344
121CDK180.43025381
122PRKDC0.42759942
123PRKCE0.42533137
124MAP3K80.42443489
125FGFR20.42238609
126CDK140.41791953
127ADRBK20.41505413
128CDK60.38050690
129PRKACB0.36348324
130FRK0.35997003
131CSNK1A10.35843809
132MAPK140.35216832
133CDK11A0.34854874
134JAK30.34337252
135DYRK1A0.33961613
136MAP3K120.33846251
137CHUK0.32633964
138RAF10.32530327
139CDK150.32032186
140STK30.31121397
141MAPK70.30783651
142KIT0.30645040
143STK100.30346028
144ALK0.29007175
145GRK10.28649571
146AKT10.28501209

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.26021547
2Mismatch repair_Homo sapiens_hsa034303.91094938
3Homologous recombination_Homo sapiens_hsa034403.73322275
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51960291
5Fanconi anemia pathway_Homo sapiens_hsa034603.38298880
6Base excision repair_Homo sapiens_hsa034102.96442354
7Spliceosome_Homo sapiens_hsa030402.85384769
8* RNA polymerase_Homo sapiens_hsa030202.81101244
9Cell cycle_Homo sapiens_hsa041102.77776996
10Non-homologous end-joining_Homo sapiens_hsa034502.68171179
11Basal transcription factors_Homo sapiens_hsa030222.67151590
12Nucleotide excision repair_Homo sapiens_hsa034202.66680287
13RNA transport_Homo sapiens_hsa030132.54385970
14One carbon pool by folate_Homo sapiens_hsa006702.43644337
15Oxidative phosphorylation_Homo sapiens_hsa001902.30134212
16* Pyrimidine metabolism_Homo sapiens_hsa002402.23116608
17RNA degradation_Homo sapiens_hsa030182.20347839
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18973423
19Parkinsons disease_Homo sapiens_hsa050122.07306468
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98188468
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97126089
22Steroid biosynthesis_Homo sapiens_hsa001001.89255779
23mRNA surveillance pathway_Homo sapiens_hsa030151.80571247
24Proteasome_Homo sapiens_hsa030501.68676850
25Huntingtons disease_Homo sapiens_hsa050161.60855207
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.59035996
27Propanoate metabolism_Homo sapiens_hsa006401.57664852
28p53 signaling pathway_Homo sapiens_hsa041151.54108671
29* Purine metabolism_Homo sapiens_hsa002301.53959188
30Systemic lupus erythematosus_Homo sapiens_hsa053221.42588399
31Fatty acid elongation_Homo sapiens_hsa000621.33048501
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26821358
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26533604
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26158861
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24309147
36Alzheimers disease_Homo sapiens_hsa050101.21158442
37Ribosome_Homo sapiens_hsa030101.13218102
38Herpes simplex infection_Homo sapiens_hsa051681.12505179
39Protein export_Homo sapiens_hsa030601.12065125
40Folate biosynthesis_Homo sapiens_hsa007901.09926163
41* Epstein-Barr virus infection_Homo sapiens_hsa051691.07767420
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07560099
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07516841
44Pyruvate metabolism_Homo sapiens_hsa006201.07417890
45* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06919680
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05482262
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.99909340
48Phototransduction_Homo sapiens_hsa047440.95284636
49Viral carcinogenesis_Homo sapiens_hsa052030.90896249
50Oocyte meiosis_Homo sapiens_hsa041140.90855017
51Collecting duct acid secretion_Homo sapiens_hsa049660.89420655
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87871119
53HTLV-I infection_Homo sapiens_hsa051660.87130084
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81893289
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79744058
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79706535
57Carbon metabolism_Homo sapiens_hsa012000.79470878
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79211586
59Primary immunodeficiency_Homo sapiens_hsa053400.78995525
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78505046
61Alcoholism_Homo sapiens_hsa050340.77592036
62beta-Alanine metabolism_Homo sapiens_hsa004100.74564214
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73363037
64Glutathione metabolism_Homo sapiens_hsa004800.73196021
65MicroRNAs in cancer_Homo sapiens_hsa052060.73173450
66Biosynthesis of amino acids_Homo sapiens_hsa012300.72752301
67Antigen processing and presentation_Homo sapiens_hsa046120.72311237
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72283692
69Measles_Homo sapiens_hsa051620.71473114
70Butanoate metabolism_Homo sapiens_hsa006500.70820828
71Fatty acid metabolism_Homo sapiens_hsa012120.69508012
72Peroxisome_Homo sapiens_hsa041460.64544490
73TGF-beta signaling pathway_Homo sapiens_hsa043500.63160214
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63095579
75Cardiac muscle contraction_Homo sapiens_hsa042600.62979266
76* Metabolic pathways_Homo sapiens_hsa011000.61858034
77Vibrio cholerae infection_Homo sapiens_hsa051100.60730495
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.60261777
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59804854
80Hematopoietic cell lineage_Homo sapiens_hsa046400.59305035
81N-Glycan biosynthesis_Homo sapiens_hsa005100.58957274
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54635585
83Small cell lung cancer_Homo sapiens_hsa052220.53587535
84Legionellosis_Homo sapiens_hsa051340.52097408
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51009372
86Synaptic vesicle cycle_Homo sapiens_hsa047210.50929069
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50389668
88Graft-versus-host disease_Homo sapiens_hsa053320.49214807
89Prostate cancer_Homo sapiens_hsa052150.49113544
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48313309
91Basal cell carcinoma_Homo sapiens_hsa052170.47610276
92Colorectal cancer_Homo sapiens_hsa052100.47498173
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.47106150
94Hepatitis B_Homo sapiens_hsa051610.45047477
95Autoimmune thyroid disease_Homo sapiens_hsa053200.42933329
96Olfactory transduction_Homo sapiens_hsa047400.41767325
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41527913
98GABAergic synapse_Homo sapiens_hsa047270.40663455
99Allograft rejection_Homo sapiens_hsa053300.39207683
100Selenocompound metabolism_Homo sapiens_hsa004500.38209273
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37278417
102Sphingolipid metabolism_Homo sapiens_hsa006000.37188896
103Taste transduction_Homo sapiens_hsa047420.37062310
104Type I diabetes mellitus_Homo sapiens_hsa049400.36722605
105Apoptosis_Homo sapiens_hsa042100.36633350
106Vitamin B6 metabolism_Homo sapiens_hsa007500.36587123
107Hippo signaling pathway_Homo sapiens_hsa043900.36172991
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36080899
109Thyroid cancer_Homo sapiens_hsa052160.36002639
110Circadian rhythm_Homo sapiens_hsa047100.35889643
111Wnt signaling pathway_Homo sapiens_hsa043100.33848055
112FoxO signaling pathway_Homo sapiens_hsa040680.32357653
113Dopaminergic synapse_Homo sapiens_hsa047280.31849760
114T cell receptor signaling pathway_Homo sapiens_hsa046600.31216844
115Adherens junction_Homo sapiens_hsa045200.30985348
116Pancreatic cancer_Homo sapiens_hsa052120.30853045
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30166464
118Influenza A_Homo sapiens_hsa051640.30141372
119Pathways in cancer_Homo sapiens_hsa052000.29925097
120Hedgehog signaling pathway_Homo sapiens_hsa043400.29374205
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29187745
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29172365
123Nicotine addiction_Homo sapiens_hsa050330.29037640
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28411361
125Sulfur metabolism_Homo sapiens_hsa009200.28351212
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27857518
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27838794
128Melanoma_Homo sapiens_hsa052180.27819294
129Arachidonic acid metabolism_Homo sapiens_hsa005900.27539994
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.26474076
131Lysine degradation_Homo sapiens_hsa003100.26150201
132Nitrogen metabolism_Homo sapiens_hsa009100.24413762
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23813558
134Other glycan degradation_Homo sapiens_hsa005110.23233474
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23225148
136Arginine and proline metabolism_Homo sapiens_hsa003300.22867478
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21890747
138Endometrial cancer_Homo sapiens_hsa052130.20835326
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19879520
140Fatty acid degradation_Homo sapiens_hsa000710.19571971
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19054710
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19029918
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18047501
144Regulation of autophagy_Homo sapiens_hsa041400.17809130
145Non-small cell lung cancer_Homo sapiens_hsa052230.16808617
146Inositol phosphate metabolism_Homo sapiens_hsa005620.16544162
147TNF signaling pathway_Homo sapiens_hsa046680.16132856
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15424519
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.15340393
150Chronic myeloid leukemia_Homo sapiens_hsa052200.14695713
151Tight junction_Homo sapiens_hsa045300.14003430
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12323039

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