

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | establishment of integrated proviral latency (GO:0075713) | 5.76428929 |
| 2 | nucleobase biosynthetic process (GO:0046112) | 5.28995876 |
| 3 | purine nucleobase biosynthetic process (GO:0009113) | 5.27907192 |
| 4 | mitotic metaphase plate congression (GO:0007080) | 4.95127508 |
| 5 | protein localization to kinetochore (GO:0034501) | 4.93656312 |
| 6 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 4.64489699 |
| 7 | regulation of mitotic spindle checkpoint (GO:1903504) | 4.64489699 |
| 8 | ribosome assembly (GO:0042255) | 4.62368144 |
| 9 | DNA replication checkpoint (GO:0000076) | 4.62157768 |
| 10 | nuclear pore organization (GO:0006999) | 4.47043200 |
| 11 | DNA replication initiation (GO:0006270) | 4.36849596 |
| 12 | establishment of viral latency (GO:0019043) | 4.35789483 |
| 13 | formation of translation preinitiation complex (GO:0001731) | 4.34389943 |
| 14 | maturation of SSU-rRNA (GO:0030490) | 4.20485639 |
| 15 | IMP biosynthetic process (GO:0006188) | 4.18385073 |
| 16 | metaphase plate congression (GO:0051310) | 4.18231772 |
| 17 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 4.15545000 |
| 18 | ribosome biogenesis (GO:0042254) | 4.13209275 |
| 19 | mitotic nuclear envelope disassembly (GO:0007077) | 4.12106775 |
| 20 | protein localization to chromosome, centromeric region (GO:0071459) | 4.11765374 |
| 21 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.10757956 |
| 22 | nuclear pore complex assembly (GO:0051292) | 4.03263107 |
| 23 | DNA unwinding involved in DNA replication (GO:0006268) | 4.02001773 |
| 24 | chaperone-mediated protein transport (GO:0072321) | 4.01451953 |
| 25 | DNA strand elongation (GO:0022616) | 3.91956919 |
| 26 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.91501069 |
| 27 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.88305536 |
| 28 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.88305536 |
| 29 | L-serine metabolic process (GO:0006563) | 3.86582473 |
| 30 | nuclear envelope disassembly (GO:0051081) | 3.84577716 |
| 31 | membrane disassembly (GO:0030397) | 3.84577716 |
| 32 | regulation of spindle organization (GO:0090224) | 3.83698817 |
| 33 | chromatin remodeling at centromere (GO:0031055) | 3.81563067 |
| 34 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.81030130 |
| 35 | CENP-A containing nucleosome assembly (GO:0034080) | 3.79733956 |
| 36 | DNA double-strand break processing (GO:0000729) | 3.79110076 |
| 37 | telomere maintenance via telomerase (GO:0007004) | 3.76868171 |
| 38 | folic acid metabolic process (GO:0046655) | 3.73252989 |
| 39 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.69057778 |
| 40 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.67701810 |
| 41 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.67355662 |
| 42 | heterochromatin organization (GO:0070828) | 3.67260021 |
| 43 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.64615450 |
| 44 | IMP metabolic process (GO:0046040) | 3.63113201 |
| 45 | protein complex localization (GO:0031503) | 3.56958283 |
| 46 | ribosomal large subunit biogenesis (GO:0042273) | 3.56857117 |
| 47 | establishment of chromosome localization (GO:0051303) | 3.54245423 |
| 48 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.54171300 |
| 49 | DNA damage response, detection of DNA damage (GO:0042769) | 3.49429704 |
| 50 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.49396694 |
| 51 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.48536508 |
| 52 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.47511063 |
| 53 | DNA replication-independent nucleosome organization (GO:0034724) | 3.47511063 |
| 54 | negative regulation of telomerase activity (GO:0051974) | 3.45208458 |
| 55 | RNA-dependent DNA replication (GO:0006278) | 3.44833736 |
| 56 | positive regulation of chromosome segregation (GO:0051984) | 3.44767166 |
| 57 | spindle checkpoint (GO:0031577) | 3.43454608 |
| 58 | negative regulation of mitosis (GO:0045839) | 3.43453135 |
| 59 | pre-miRNA processing (GO:0031054) | 3.39561704 |
| 60 | rRNA processing (GO:0006364) | 3.38725253 |
| 61 | mitotic chromosome condensation (GO:0007076) | 3.38491497 |
| 62 | telomere maintenance via recombination (GO:0000722) | 3.36520961 |
| 63 | regulation of translational termination (GO:0006449) | 3.35968249 |
| 64 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.35893570 |
| 65 | protein neddylation (GO:0045116) | 3.35450022 |
| 66 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.35389012 |
| 67 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.34707264 |
| 68 | negative regulation of ligase activity (GO:0051352) | 3.34707264 |
| 69 | histone mRNA metabolic process (GO:0008334) | 3.34418977 |
| 70 | mitotic sister chromatid segregation (GO:0000070) | 3.34141878 |
| 71 | histone exchange (GO:0043486) | 3.33957261 |
| 72 | mitotic spindle checkpoint (GO:0071174) | 3.31163866 |
| 73 | ATP-dependent chromatin remodeling (GO:0043044) | 3.30999286 |
| 74 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.30924762 |
| 75 | regulation of gene silencing by miRNA (GO:0060964) | 3.30924762 |
| 76 | regulation of gene silencing by RNA (GO:0060966) | 3.30924762 |
| 77 | rRNA metabolic process (GO:0016072) | 3.29810457 |
| 78 | mitotic G2/M transition checkpoint (GO:0044818) | 3.29787434 |
| 79 | rRNA modification (GO:0000154) | 3.29109761 |
| 80 | mitotic recombination (GO:0006312) | 3.29102470 |
| 81 | kinetochore organization (GO:0051383) | 3.27290557 |
| 82 | spliceosomal snRNP assembly (GO:0000387) | 3.25536579 |
| 83 | negative regulation of chromosome segregation (GO:0051985) | 3.25174360 |
| 84 | protein K6-linked ubiquitination (GO:0085020) | 3.24772842 |
| 85 | regulation of mitotic spindle organization (GO:0060236) | 3.24039568 |
| 86 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.23343264 |
| 87 | telomere maintenance via telomere lengthening (GO:0010833) | 3.22624280 |
| 88 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.20420802 |
| 89 | negative regulation of sister chromatid segregation (GO:0033046) | 3.20420802 |
| 90 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.20420802 |
| 91 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.20420802 |
| 92 | protein localization to chromosome (GO:0034502) | 3.19275413 |
| 93 | pore complex assembly (GO:0046931) | 3.18665435 |
| 94 | non-recombinational repair (GO:0000726) | 3.16685862 |
| 95 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.16685862 |
| 96 | negative regulation of DNA recombination (GO:0045910) | 3.16471180 |
| 97 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.16417358 |
| 98 | regulation of chromosome segregation (GO:0051983) | 3.16393330 |
| 99 | cellular protein complex localization (GO:0034629) | 3.14321740 |
| 100 | chromatin assembly or disassembly (GO:0006333) | 3.14035017 |
| 101 | regulation of centrosome cycle (GO:0046605) | 3.13616871 |
| 102 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435) | 3.12378073 |
| 103 | spindle assembly checkpoint (GO:0071173) | 3.12367183 |
| 104 | regulation of spindle checkpoint (GO:0090231) | 3.11306097 |
| 105 | mitotic spindle assembly checkpoint (GO:0007094) | 3.11122744 |
| 106 | DNA ligation (GO:0006266) | 3.10945159 |
| 107 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.10067194 |
| 108 | negative regulation of nuclear division (GO:0051784) | 3.09226934 |
| 109 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.08887720 |
| 110 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.08685653 |
| 111 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.08636838 |
| 112 | response to X-ray (GO:0010165) | 3.07868313 |
| 113 | DNA duplex unwinding (GO:0032508) | 3.07103815 |
| 114 | transcription from RNA polymerase I promoter (GO:0006360) | 3.06572655 |
| 115 | DNA geometric change (GO:0032392) | 3.05982202 |
| 116 | kinetochore assembly (GO:0051382) | 3.05962059 |
| 117 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.05476974 |
| 118 | rRNA methylation (GO:0031167) | 3.05179778 |
| 119 | termination of RNA polymerase I transcription (GO:0006363) | 3.04784382 |
| 120 | proteasome assembly (GO:0043248) | 3.04671564 |
| 121 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.04284386 |
| 122 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.04284386 |
| 123 | nuclear envelope organization (GO:0006998) | 3.02632067 |
| 124 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.00951846 |
| 125 | regulation of centriole replication (GO:0046599) | 2.99411099 |
| 126 | DNA deamination (GO:0045006) | 2.99375910 |
| 127 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.98329676 |
| 128 | regulation of helicase activity (GO:0051095) | 2.97859368 |
| 129 | translational initiation (GO:0006413) | 2.97169474 |
| 130 | maturation of 5.8S rRNA (GO:0000460) | 2.95835540 |
| 131 | pseudouridine synthesis (GO:0001522) | 2.94119922 |
| 132 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.93101983 |
| 133 | cell cycle G1/S phase transition (GO:0044843) | 2.93101983 |
| 134 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.92133578 |
| 135 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.92133578 |
| 136 | regulation of sister chromatid segregation (GO:0033045) | 2.92133578 |
| 137 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.91717423 |
| 138 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.91474327 |
| 139 | sister chromatid segregation (GO:0000819) | 2.90731156 |
| 140 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.89091124 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.38290461 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.34494078 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.00974432 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.57995201 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.24297400 |
| 6 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.15607502 |
| 7 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.06012590 |
| 8 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.05986017 |
| 9 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.87914335 |
| 10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.77277057 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.74945679 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.74491069 |
| 13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.73602399 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.71981161 |
| 15 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.68998647 |
| 16 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.53725432 |
| 17 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.45516033 |
| 18 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.38806493 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.31646249 |
| 20 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.23545653 |
| 21 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.11039360 |
| 22 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.09939257 |
| 23 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.08787687 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.07932037 |
| 25 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 2.04214012 |
| 26 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.03471077 |
| 27 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.00263446 |
| 28 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.97155758 |
| 29 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.95764803 |
| 30 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.92918923 |
| 31 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.90124763 |
| 32 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.86821982 |
| 33 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.86158713 |
| 34 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.80518917 |
| 35 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.79505972 |
| 36 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.75185566 |
| 37 | * NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.73520182 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.70112608 |
| 39 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.68825007 |
| 40 | * POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.61494514 |
| 41 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.61309077 |
| 42 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.60609988 |
| 43 | * SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.55409016 |
| 44 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.54378351 |
| 45 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.53106306 |
| 46 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.51554389 |
| 47 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.50683165 |
| 48 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.50564485 |
| 49 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.50016580 |
| 50 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.48672091 |
| 51 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.45858267 |
| 52 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.45376669 |
| 53 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.44276345 |
| 54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.44266645 |
| 55 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.44207721 |
| 56 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.43158404 |
| 57 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.41127190 |
| 58 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.41127190 |
| 59 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.41127190 |
| 60 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.40340678 |
| 61 | EWS_26573619_Chip-Seq_HEK293_Human | 1.37497486 |
| 62 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.34266884 |
| 63 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.32751276 |
| 64 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.28224195 |
| 65 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.27724014 |
| 66 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.26408014 |
| 67 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.26038975 |
| 68 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.24203000 |
| 69 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.22031586 |
| 70 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.20841308 |
| 71 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.19902980 |
| 72 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.19562150 |
| 73 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.18033392 |
| 74 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.14989291 |
| 75 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.12377979 |
| 76 | FUS_26573619_Chip-Seq_HEK293_Human | 1.11188628 |
| 77 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.11165634 |
| 78 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10300544 |
| 79 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.09383852 |
| 80 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.09117313 |
| 81 | MYC_22102868_ChIP-Seq_BL_Human | 1.08934283 |
| 82 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.08263534 |
| 83 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.08192114 |
| 84 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07476437 |
| 85 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.06305663 |
| 86 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.05001502 |
| 87 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.04790098 |
| 88 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.04695722 |
| 89 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.02975272 |
| 90 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.02218315 |
| 91 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.00394602 |
| 92 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.99871650 |
| 93 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99623675 |
| 94 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.97307362 |
| 95 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.97150661 |
| 96 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.97125307 |
| 97 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.95376559 |
| 98 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.94775431 |
| 99 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.94475995 |
| 100 | * TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.93912179 |
| 101 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.93489295 |
| 102 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.93145404 |
| 103 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.92170519 |
| 104 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.91428615 |
| 105 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.90353570 |
| 106 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.90290857 |
| 107 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.90223309 |
| 108 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.87992520 |
| 109 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.87786450 |
| 110 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.87766099 |
| 111 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.86326182 |
| 112 | * MYC_18940864_ChIP-ChIP_HL60_Human | 0.85967146 |
| 113 | VDR_22108803_ChIP-Seq_LS180_Human | 0.84897830 |
| 114 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.83152175 |
| 115 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.78370732 |
| 116 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.77559831 |
| 117 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.74758123 |
| 118 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.73149754 |
| 119 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.71901876 |
| 120 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.70762925 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.95842656 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.82752725 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.74608149 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 4.72526859 |
| 5 | MP0008057_abnormal_DNA_replication | 4.30735350 |
| 6 | MP0003077_abnormal_cell_cycle | 4.05746045 |
| 7 | MP0008058_abnormal_DNA_repair | 3.26095431 |
| 8 | MP0003123_paternal_imprinting | 3.08513328 |
| 9 | MP0002254_reproductive_system_inflammat | 2.86780791 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.77941985 |
| 11 | MP0001188_hyperpigmentation | 2.75220947 |
| 12 | MP0001730_embryonic_growth_arrest | 2.71692171 |
| 13 | MP0006292_abnormal_olfactory_placode | 2.53943208 |
| 14 | MP0010352_gastrointestinal_tract_polyps | 2.51884046 |
| 15 | MP0008877_abnormal_DNA_methylation | 2.48805785 |
| 16 | MP0008007_abnormal_cellular_replicative | 2.47195420 |
| 17 | MP0000350_abnormal_cell_proliferation | 2.31608647 |
| 18 | MP0003718_maternal_effect | 2.29284308 |
| 19 | MP0003806_abnormal_nucleotide_metabolis | 2.24158598 |
| 20 | MP0003786_premature_aging | 2.22176700 |
| 21 | MP0001672_abnormal_embryogenesis/_devel | 2.02268268 |
| 22 | MP0005380_embryogenesis_phenotype | 2.02268268 |
| 23 | MP0010307_abnormal_tumor_latency | 1.91159767 |
| 24 | MP0001697_abnormal_embryo_size | 1.89253476 |
| 25 | MP0002396_abnormal_hematopoietic_system | 1.79633997 |
| 26 | MP0003984_embryonic_growth_retardation | 1.76868007 |
| 27 | MP0002088_abnormal_embryonic_growth/wei | 1.74954215 |
| 28 | MP0002080_prenatal_lethality | 1.71617002 |
| 29 | MP0003567_abnormal_fetal_cardiomyocyte | 1.69453308 |
| 30 | MP0002084_abnormal_developmental_patter | 1.66027107 |
| 31 | MP0000579_abnormal_nail_morphology | 1.65199899 |
| 32 | MP0002085_abnormal_embryonic_tissue | 1.63548841 |
| 33 | MP0003941_abnormal_skin_development | 1.60982042 |
| 34 | MP0002086_abnormal_extraembryonic_tissu | 1.57555586 |
| 35 | MP0003136_yellow_coat_color | 1.54440523 |
| 36 | MP0004197_abnormal_fetal_growth/weight/ | 1.45466765 |
| 37 | MP0003315_abnormal_perineum_morphology | 1.41069788 |
| 38 | MP0003890_abnormal_embryonic-extraembry | 1.35203108 |
| 39 | MP0000313_abnormal_cell_death | 1.33165430 |
| 40 | MP0002210_abnormal_sex_determination | 1.31440205 |
| 41 | MP0000490_abnormal_crypts_of | 1.26794214 |
| 42 | MP0002697_abnormal_eye_size | 1.24076808 |
| 43 | MP0002019_abnormal_tumor_incidence | 1.22559627 |
| 44 | MP0001145_abnormal_male_reproductive | 1.18660307 |
| 45 | MP0009379_abnormal_foot_pigmentation | 1.17662425 |
| 46 | MP0001293_anophthalmia | 1.17173796 |
| 47 | MP0000537_abnormal_urethra_morphology | 1.17067494 |
| 48 | MP0003121_genomic_imprinting | 1.15927598 |
| 49 | MP0002938_white_spotting | 1.12836048 |
| 50 | MP0005076_abnormal_cell_differentiation | 1.12045832 |
| 51 | MP0009672_abnormal_birth_weight | 1.11493325 |
| 52 | MP0006072_abnormal_retinal_apoptosis | 1.10837450 |
| 53 | MP0003221_abnormal_cardiomyocyte_apopto | 1.10615626 |
| 54 | MP0003186_abnormal_redox_activity | 1.09287130 |
| 55 | MP0001177_atelectasis | 1.09273574 |
| 56 | MP0001529_abnormal_vocalization | 1.07634220 |
| 57 | MP0002796_impaired_skin_barrier | 1.06724855 |
| 58 | MP0005451_abnormal_body_composition | 1.05819936 |
| 59 | MP0001929_abnormal_gametogenesis | 1.04475756 |
| 60 | MP0005501_abnormal_skin_physiology | 1.01908066 |
| 61 | MP0000653_abnormal_sex_gland | 1.01813016 |
| 62 | MP0002160_abnormal_reproductive_system | 0.97673898 |
| 63 | MP0003119_abnormal_digestive_system | 0.95821329 |
| 64 | MP0003566_abnormal_cell_adhesion | 0.95609311 |
| 65 | MP0003787_abnormal_imprinting | 0.89549781 |
| 66 | MP0000358_abnormal_cell_content/ | 0.89459487 |
| 67 | MP0002736_abnormal_nociception_after | 0.88609010 |
| 68 | MP0001661_extended_life_span | 0.87455810 |
| 69 | MP0003937_abnormal_limbs/digits/tail_de | 0.87047416 |
| 70 | MP0009697_abnormal_copulation | 0.86418839 |
| 71 | MP0002233_abnormal_nose_morphology | 0.85954985 |
| 72 | MP0010030_abnormal_orbit_morphology | 0.85569358 |
| 73 | MP0005389_reproductive_system_phenotype | 0.83756231 |
| 74 | MP0009703_decreased_birth_body | 0.83019318 |
| 75 | MP0002090_abnormal_vision | 0.82602535 |
| 76 | MP0002653_abnormal_ependyma_morphology | 0.82170051 |
| 77 | MP0002111_abnormal_tail_morphology | 0.82065728 |
| 78 | MP0009333_abnormal_splenocyte_physiolog | 0.82016499 |
| 79 | MP0005384_cellular_phenotype | 0.81345593 |
| 80 | MP0008260_abnormal_autophagy | 0.81181402 |
| 81 | MP0009053_abnormal_anal_canal | 0.80512450 |
| 82 | MP0004808_abnormal_hematopoietic_stem | 0.79992757 |
| 83 | MP0005621_abnormal_cell_physiology | 0.79298412 |
| 84 | MP0000049_abnormal_middle_ear | 0.78991357 |
| 85 | MP0001986_abnormal_taste_sensitivity | 0.77911681 |
| 86 | MP0001485_abnormal_pinna_reflex | 0.77838111 |
| 87 | MP0001545_abnormal_hematopoietic_system | 0.77235174 |
| 88 | MP0005397_hematopoietic_system_phenotyp | 0.77235174 |
| 89 | MP0003705_abnormal_hypodermis_morpholog | 0.77137961 |
| 90 | MP0002751_abnormal_autonomic_nervous | 0.75703068 |
| 91 | MP0008789_abnormal_olfactory_epithelium | 0.75526013 |
| 92 | MP0001119_abnormal_female_reproductive | 0.75372395 |
| 93 | MP0009840_abnormal_foam_cell | 0.74479600 |
| 94 | MP0001299_abnormal_eye_distance/ | 0.71878957 |
| 95 | MP0005023_abnormal_wound_healing | 0.70635944 |
| 96 | MP0005395_other_phenotype | 0.70052114 |
| 97 | MP0004133_heterotaxia | 0.69450742 |
| 98 | MP0001216_abnormal_epidermal_layer | 0.69290751 |
| 99 | MP0002102_abnormal_ear_morphology | 0.68564419 |
| 100 | MP0004264_abnormal_extraembryonic_tissu | 0.68403861 |
| 101 | MP0000762_abnormal_tongue_morphology | 0.66798410 |
| 102 | MP0003861_abnormal_nervous_system | 0.64733584 |
| 103 | MP0000627_abnormal_mammary_gland | 0.64611022 |
| 104 | MP0006035_abnormal_mitochondrial_morpho | 0.64047973 |
| 105 | MP0004084_abnormal_cardiac_muscle | 0.63165247 |
| 106 | MP0005266_abnormal_metabolism | 0.62814818 |
| 107 | MP0001286_abnormal_eye_development | 0.62536152 |
| 108 | MP0006036_abnormal_mitochondrial_physio | 0.62422820 |
| 109 | MP0001849_ear_inflammation | 0.61751959 |
| 110 | MP0000432_abnormal_head_morphology | 0.61533893 |
| 111 | MP0003878_abnormal_ear_physiology | 0.61132475 |
| 112 | MP0005377_hearing/vestibular/ear_phenot | 0.61132475 |
| 113 | MP0001764_abnormal_homeostasis | 0.60890614 |
| 114 | MP0003699_abnormal_female_reproductive | 0.60270127 |
| 115 | MP0004185_abnormal_adipocyte_glucose | 0.59826911 |
| 116 | MP0002092_abnormal_eye_morphology | 0.58867515 |
| 117 | MP0003936_abnormal_reproductive_system | 0.58280469 |
| 118 | MP0002277_abnormal_respiratory_mucosa | 0.58182882 |
| 119 | MP0002132_abnormal_respiratory_system | 0.57926190 |
| 120 | MP0008770_decreased_survivor_rate | 0.57841601 |
| 121 | MP0000428_abnormal_craniofacial_morphol | 0.57587549 |
| 122 | MP0002127_abnormal_cardiovascular_syste | 0.56378303 |
| 123 | MP0003755_abnormal_palate_morphology | 0.56057814 |
| 124 | MP0001919_abnormal_reproductive_system | 0.56044235 |
| 125 | MP0004215_abnormal_myocardial_fiber | 0.56021948 |
| 126 | MP0000377_abnormal_hair_follicle | 0.55908105 |
| 127 | MP0000647_abnormal_sebaceous_gland | 0.55872214 |
| 128 | MP0000703_abnormal_thymus_morphology | 0.54436956 |
| 129 | MP0010234_abnormal_vibrissa_follicle | 0.53041324 |
| 130 | MP0001727_abnormal_embryo_implantation | 0.52798946 |
| 131 | MP0002161_abnormal_fertility/fecundity | 0.51632818 |
| 132 | MP0003698_abnormal_male_reproductive | 0.51215517 |
| 133 | MP0001984_abnormal_olfaction | 0.46071216 |
| 134 | MP0005391_vision/eye_phenotype | 0.44335077 |
| 135 | MP0002081_perinatal_lethality | 0.43871807 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.13927794 |
| 2 | Breast hypoplasia (HP:0003187) | 4.49389493 |
| 3 | Chromsome breakage (HP:0040012) | 4.46755127 |
| 4 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.21244389 |
| 5 | Impulsivity (HP:0100710) | 3.90917795 |
| 6 | Reticulocytopenia (HP:0001896) | 3.84095562 |
| 7 | Carpal bone hypoplasia (HP:0001498) | 3.80743145 |
| 8 | Abnormality of chromosome stability (HP:0003220) | 3.49289238 |
| 9 | Abnormality of the labia minora (HP:0012880) | 3.48041270 |
| 10 | Selective tooth agenesis (HP:0001592) | 3.47368545 |
| 11 | Oral leukoplakia (HP:0002745) | 3.47214829 |
| 12 | Absent radius (HP:0003974) | 3.44848992 |
| 13 | Ependymoma (HP:0002888) | 3.44459533 |
| 14 | Patellar aplasia (HP:0006443) | 3.29140092 |
| 15 | Abnormality of the preputium (HP:0100587) | 3.28042754 |
| 16 | Cerebral hypomyelination (HP:0006808) | 3.26367458 |
| 17 | Meckel diverticulum (HP:0002245) | 3.21407831 |
| 18 | Rough bone trabeculation (HP:0100670) | 3.21123967 |
| 19 | Colon cancer (HP:0003003) | 3.18258163 |
| 20 | Ureteral duplication (HP:0000073) | 3.18158113 |
| 21 | Aplasia involving forearm bones (HP:0009822) | 3.17887374 |
| 22 | Absent forearm bone (HP:0003953) | 3.17887374 |
| 23 | Nephroblastoma (Wilms tumor) (HP:0002667) | 3.16444763 |
| 24 | Septo-optic dysplasia (HP:0100842) | 3.15903384 |
| 25 | Absent thumb (HP:0009777) | 3.11208981 |
| 26 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.10952804 |
| 27 | Acute necrotizing encephalopathy (HP:0006965) | 3.09781511 |
| 28 | Abnormality of methionine metabolism (HP:0010901) | 3.07941872 |
| 29 | Abnormality of the anterior horn cell (HP:0006802) | 3.06439552 |
| 30 | Degeneration of anterior horn cells (HP:0002398) | 3.06439552 |
| 31 | Increased hepatocellular lipid droplets (HP:0006565) | 3.06046794 |
| 32 | Abnormality of the ileum (HP:0001549) | 3.03801151 |
| 33 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.01608291 |
| 34 | Medulloblastoma (HP:0002885) | 3.00716136 |
| 35 | Embryonal renal neoplasm (HP:0011794) | 2.95253622 |
| 36 | Homocystinuria (HP:0002156) | 2.92810549 |
| 37 | Abnormality of homocysteine metabolism (HP:0010919) | 2.92810549 |
| 38 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.92804847 |
| 39 | Acute encephalopathy (HP:0006846) | 2.92430132 |
| 40 | Premature ovarian failure (HP:0008209) | 2.92021044 |
| 41 | Supernumerary spleens (HP:0009799) | 2.81994212 |
| 42 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.76851840 |
| 43 | Abnormality of serum amino acid levels (HP:0003112) | 2.74419652 |
| 44 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.66856320 |
| 45 | Ectopic kidney (HP:0000086) | 2.66195356 |
| 46 | Lipid accumulation in hepatocytes (HP:0006561) | 2.65317851 |
| 47 | Rhabdomyosarcoma (HP:0002859) | 2.63538418 |
| 48 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.60187212 |
| 49 | Duplicated collecting system (HP:0000081) | 2.59366307 |
| 50 | Hypoglycemic seizures (HP:0002173) | 2.59188759 |
| 51 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.58658773 |
| 52 | Horseshoe kidney (HP:0000085) | 2.57954963 |
| 53 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.57596968 |
| 54 | Agnosia (HP:0010524) | 2.57454034 |
| 55 | Small intestinal stenosis (HP:0012848) | 2.53402440 |
| 56 | Duodenal stenosis (HP:0100867) | 2.53402440 |
| 57 | Abnormal trabecular bone morphology (HP:0100671) | 2.50824288 |
| 58 | Hyperglycinemia (HP:0002154) | 2.48338497 |
| 59 | Abnormal number of erythroid precursors (HP:0012131) | 2.48198503 |
| 60 | Methylmalonic acidemia (HP:0002912) | 2.44170559 |
| 61 | Macrocytic anemia (HP:0001972) | 2.43469736 |
| 62 | Progressive macrocephaly (HP:0004481) | 2.42157609 |
| 63 | Aplastic anemia (HP:0001915) | 2.40524758 |
| 64 | Bone marrow hypocellularity (HP:0005528) | 2.39285123 |
| 65 | 11 pairs of ribs (HP:0000878) | 2.38976293 |
| 66 | Neoplasm of the colon (HP:0100273) | 2.34993594 |
| 67 | Secondary amenorrhea (HP:0000869) | 2.34762629 |
| 68 | Neoplasm of the pancreas (HP:0002894) | 2.32972892 |
| 69 | Myelodysplasia (HP:0002863) | 2.32033306 |
| 70 | Cerebral edema (HP:0002181) | 2.31258827 |
| 71 | Spastic diplegia (HP:0001264) | 2.30461118 |
| 72 | Cortical dysplasia (HP:0002539) | 2.29825650 |
| 73 | Multiple enchondromatosis (HP:0005701) | 2.26973379 |
| 74 | Mitochondrial inheritance (HP:0001427) | 2.26166736 |
| 75 | Sparse eyelashes (HP:0000653) | 2.24603204 |
| 76 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.22458638 |
| 77 | Sloping forehead (HP:0000340) | 2.21527776 |
| 78 | Increased CSF lactate (HP:0002490) | 2.21361366 |
| 79 | Bilateral microphthalmos (HP:0007633) | 2.21003894 |
| 80 | Absent septum pellucidum (HP:0001331) | 2.18824863 |
| 81 | Abnormality of the septum pellucidum (HP:0007375) | 2.18657076 |
| 82 | Biliary tract neoplasm (HP:0100574) | 2.17810397 |
| 83 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.17770889 |
| 84 | Abnormality of glycine metabolism (HP:0010895) | 2.17770889 |
| 85 | Abnormality of the duodenum (HP:0002246) | 2.15919246 |
| 86 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.15817779 |
| 87 | Abnormal spermatogenesis (HP:0008669) | 2.15197762 |
| 88 | Triphalangeal thumb (HP:0001199) | 2.12347982 |
| 89 | Abnormal hair whorl (HP:0010721) | 2.12144479 |
| 90 | Proximal placement of thumb (HP:0009623) | 2.11749338 |
| 91 | Premature graying of hair (HP:0002216) | 2.11240098 |
| 92 | Trismus (HP:0000211) | 2.10356736 |
| 93 | Leukodystrophy (HP:0002415) | 2.10337843 |
| 94 | Facial cleft (HP:0002006) | 2.09449441 |
| 95 | Missing ribs (HP:0000921) | 2.09007923 |
| 96 | Abnormality of the renal collecting system (HP:0004742) | 2.08709183 |
| 97 | Areflexia of lower limbs (HP:0002522) | 2.06719081 |
| 98 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.06589128 |
| 99 | Microretrognathia (HP:0000308) | 2.06056957 |
| 100 | Deviation of the thumb (HP:0009603) | 2.05196861 |
| 101 | Megaloblastic anemia (HP:0001889) | 2.05107054 |
| 102 | Tracheoesophageal fistula (HP:0002575) | 2.04143411 |
| 103 | Abnormality of the astrocytes (HP:0100707) | 2.04095262 |
| 104 | Astrocytoma (HP:0009592) | 2.04095262 |
| 105 | Progressive muscle weakness (HP:0003323) | 2.04040143 |
| 106 | Cellular immunodeficiency (HP:0005374) | 2.03741582 |
| 107 | Prominent nose (HP:0000448) | 2.03500497 |
| 108 | Symptomatic seizures (HP:0011145) | 2.02715541 |
| 109 | Sensory axonal neuropathy (HP:0003390) | 2.02391676 |
| 110 | Squamous cell carcinoma (HP:0002860) | 2.02298436 |
| 111 | CNS hypomyelination (HP:0003429) | 2.02250988 |
| 112 | Basal cell carcinoma (HP:0002671) | 2.02141729 |
| 113 | Renal Fanconi syndrome (HP:0001994) | 2.01878656 |
| 114 | Glioma (HP:0009733) | 2.01829250 |
| 115 | Methylmalonic aciduria (HP:0012120) | 2.00818011 |
| 116 | Progressive external ophthalmoplegia (HP:0000590) | 1.99850814 |
| 117 | Abnormal number of incisors (HP:0011064) | 1.99285886 |
| 118 | Abnormal biliary tract morphology (HP:0012440) | 1.99244074 |
| 119 | Abnormal lung lobation (HP:0002101) | 1.98554556 |
| 120 | Short thumb (HP:0009778) | 1.97320514 |
| 121 | Neoplasm of the adrenal gland (HP:0100631) | 1.96473982 |
| 122 | Pallor (HP:0000980) | 1.94455731 |
| 123 | Chronic bronchitis (HP:0004469) | 1.94428678 |
| 124 | Increased nuchal translucency (HP:0010880) | 1.93872139 |
| 125 | Cafe-au-lait spot (HP:0000957) | 1.91953075 |
| 126 | Spinal muscular atrophy (HP:0007269) | 1.91767167 |
| 127 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.91034149 |
| 128 | Abnormality of the umbilical cord (HP:0010881) | 1.90506635 |
| 129 | Hyperglycinuria (HP:0003108) | 1.89271772 |
| 130 | Abnormality of DNA repair (HP:0003254) | 1.89125142 |
| 131 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.88278407 |
| 132 | Hypoplasia of the pons (HP:0012110) | 1.86014261 |
| 133 | Microvesicular hepatic steatosis (HP:0001414) | 1.85656373 |
| 134 | Breast aplasia (HP:0100783) | 1.85534337 |
| 135 | Entropion (HP:0000621) | 1.85329510 |
| 136 | Maternal diabetes (HP:0009800) | 1.84846362 |
| 137 | Uterine neoplasm (HP:0010784) | 1.83642529 |
| 138 | Stenosis of the external auditory canal (HP:0000402) | 1.83077692 |
| 139 | Atresia of the external auditory canal (HP:0000413) | 1.82485580 |
| 140 | Facial hemangioma (HP:0000329) | 1.82392815 |
| 141 | Hypoglycemic coma (HP:0001325) | 1.82320484 |
| 142 | Volvulus (HP:0002580) | 1.82286227 |
| 143 | Reduced antithrombin III activity (HP:0001976) | 1.82240403 |
| 144 | Overlapping toe (HP:0001845) | 1.80353938 |
| 145 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.78945409 |
| 146 | Neoplasm of the oral cavity (HP:0100649) | 1.78190509 |
| 147 | Abnormality of the carotid arteries (HP:0005344) | 1.77814082 |
| 148 | Choanal stenosis (HP:0000452) | 1.77562864 |
| 149 | Hypoplasia of the radius (HP:0002984) | 1.75166788 |
| 150 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.74724237 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | WEE1 | 5.30189888 |
| 2 | BUB1 | 4.36147236 |
| 3 | CDC7 | 3.84546480 |
| 4 | VRK2 | 3.20927857 |
| 5 | PBK | 3.03243381 |
| 6 | BRSK2 | 2.98124393 |
| 7 | EIF2AK1 | 2.92827216 |
| 8 | TNIK | 2.88645102 |
| 9 | PLK4 | 2.67313194 |
| 10 | NEK1 | 2.66836871 |
| 11 | NEK2 | 2.57126581 |
| 12 | TSSK6 | 2.52899064 |
| 13 | TTK | 2.52016243 |
| 14 | SRPK1 | 2.45536265 |
| 15 | TAF1 | 2.40413792 |
| 16 | ACVR1B | 2.36582417 |
| 17 | EPHA2 | 2.36412357 |
| 18 | PLK1 | 2.13719447 |
| 19 | NME1 | 1.87767519 |
| 20 | NUAK1 | 1.86515902 |
| 21 | PLK3 | 1.86204192 |
| 22 | CDK12 | 1.73288843 |
| 23 | EIF2AK3 | 1.68493925 |
| 24 | CDK7 | 1.66269848 |
| 25 | RPS6KB2 | 1.65603508 |
| 26 | TRIM28 | 1.65568658 |
| 27 | BRSK1 | 1.65259950 |
| 28 | AURKB | 1.59809910 |
| 29 | NME2 | 1.59434873 |
| 30 | MKNK1 | 1.59218151 |
| 31 | MKNK2 | 1.53089130 |
| 32 | PNCK | 1.52665831 |
| 33 | AKT3 | 1.45841852 |
| 34 | DYRK3 | 1.45838908 |
| 35 | STK38L | 1.45045763 |
| 36 | STK16 | 1.44460627 |
| 37 | ZAK | 1.44312234 |
| 38 | ATR | 1.44114258 |
| 39 | WNK3 | 1.43543853 |
| 40 | LATS2 | 1.37852445 |
| 41 | MAP3K8 | 1.35667513 |
| 42 | STK3 | 1.32911090 |
| 43 | CHEK2 | 1.32094484 |
| 44 | CDK4 | 1.31170372 |
| 45 | TESK2 | 1.27090370 |
| 46 | AURKA | 1.26933636 |
| 47 | VRK1 | 1.23022500 |
| 48 | CHEK1 | 1.22714696 |
| 49 | PDK3 | 1.20364652 |
| 50 | PDK4 | 1.20364652 |
| 51 | RPS6KA4 | 1.18733705 |
| 52 | STK10 | 1.18206927 |
| 53 | PASK | 1.16244717 |
| 54 | STK24 | 1.11895928 |
| 55 | BMPR1B | 1.03053651 |
| 56 | ALK | 1.02351044 |
| 57 | BCKDK | 1.02054749 |
| 58 | FLT3 | 0.99650622 |
| 59 | CDK19 | 0.88526391 |
| 60 | ATM | 0.88303097 |
| 61 | CCNB1 | 0.87438919 |
| 62 | CDK2 | 0.85723027 |
| 63 | TLK1 | 0.85537867 |
| 64 | STK4 | 0.84892717 |
| 65 | PDK2 | 0.80220986 |
| 66 | SCYL2 | 0.78784972 |
| 67 | MAPKAPK3 | 0.75937415 |
| 68 | PIM1 | 0.75809781 |
| 69 | PRKCI | 0.75005007 |
| 70 | NLK | 0.73798856 |
| 71 | CSNK2A2 | 0.72029212 |
| 72 | CDK6 | 0.66535098 |
| 73 | ERBB4 | 0.61427492 |
| 74 | TESK1 | 0.61200997 |
| 75 | CSNK2A1 | 0.61012727 |
| 76 | CDK1 | 0.60962643 |
| 77 | OXSR1 | 0.60854595 |
| 78 | BRAF | 0.60580087 |
| 79 | CSNK1E | 0.59516950 |
| 80 | PAK1 | 0.58838215 |
| 81 | MARK3 | 0.57354664 |
| 82 | MELK | 0.56852644 |
| 83 | PAK4 | 0.55797938 |
| 84 | TGFBR1 | 0.53692525 |
| 85 | LIMK1 | 0.53563431 |
| 86 | DMPK | 0.49265022 |
| 87 | BRD4 | 0.48983673 |
| 88 | LATS1 | 0.48796349 |
| 89 | PIM2 | 0.48441185 |
| 90 | CDK3 | 0.47086629 |
| 91 | MAP3K9 | 0.46847276 |
| 92 | EIF2AK2 | 0.46703124 |
| 93 | SMG1 | 0.46568829 |
| 94 | MAP3K3 | 0.45298193 |
| 95 | BCR | 0.43616968 |
| 96 | FGFR1 | 0.41617720 |
| 97 | PKN2 | 0.41090648 |
| 98 | DAPK1 | 0.41055626 |
| 99 | MTOR | 0.40978849 |
| 100 | PLK2 | 0.40431529 |
| 101 | TIE1 | 0.40337508 |
| 102 | EEF2K | 0.38775240 |
| 103 | RPS6KA5 | 0.38575239 |
| 104 | CDK8 | 0.38025043 |
| 105 | CSNK1G2 | 0.37455400 |
| 106 | MAP2K3 | 0.37203673 |
| 107 | CLK1 | 0.35626774 |
| 108 | MAP3K11 | 0.35568351 |
| 109 | MET | 0.35068308 |
| 110 | NEK9 | 0.30881767 |
| 111 | PRKCG | 0.30143920 |
| 112 | PRKDC | 0.29841530 |
| 113 | MST4 | 0.29175535 |
| 114 | CSNK1D | 0.28618080 |
| 115 | GRK1 | 0.27837973 |
| 116 | LRRK2 | 0.27530817 |
| 117 | OBSCN | 0.27032564 |
| 118 | MAP3K5 | 0.26712249 |
| 119 | AKT2 | 0.22611255 |
| 120 | CDK9 | 0.22425285 |
| 121 | MAP3K10 | 0.21559313 |
| 122 | MAPK14 | 0.21303889 |
| 123 | CSNK1G3 | 0.20983503 |
| 124 | DYRK2 | 0.20577284 |
| 125 | CSNK1G1 | 0.18939082 |
| 126 | TEC | 0.18915069 |
| 127 | MAP2K2 | 0.17037204 |
| 128 | CSNK1A1 | 0.16648723 |
| 129 | ERBB3 | 0.16223948 |
| 130 | BMX | 0.13914868 |
| 131 | YES1 | 0.13525674 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.38960071 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.34823536 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.76462886 |
| 4 | * RNA polymerase_Homo sapiens_hsa03020 | 3.51958988 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 3.51608021 |
| 6 | Proteasome_Homo sapiens_hsa03050 | 3.31818166 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.99099661 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.88692287 |
| 9 | Cell cycle_Homo sapiens_hsa04110 | 2.85360564 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.82358795 |
| 11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.72202669 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.71793405 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.65871873 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 2.52109845 |
| 15 | * Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.43978645 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 2.27178564 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.24824885 |
| 18 | Protein export_Homo sapiens_hsa03060 | 2.15011063 |
| 19 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.11577849 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.03624391 |
| 21 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.02556396 |
| 22 | Parkinsons disease_Homo sapiens_hsa05012 | 1.94297210 |
| 23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.75035687 |
| 24 | RNA degradation_Homo sapiens_hsa03018 | 1.74393214 |
| 25 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.63718159 |
| 26 | * Purine metabolism_Homo sapiens_hsa00230 | 1.35710862 |
| 27 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.30615133 |
| 28 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.28445246 |
| 29 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.26945574 |
| 30 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.26883844 |
| 31 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.26068364 |
| 32 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.25883129 |
| 33 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.25463852 |
| 34 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.22632149 |
| 35 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.22049634 |
| 36 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.19102493 |
| 37 | * Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.17744063 |
| 38 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.17225862 |
| 39 | Alzheimers disease_Homo sapiens_hsa05010 | 1.16001240 |
| 40 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.14629414 |
| 41 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.13558862 |
| 42 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.09922521 |
| 43 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.99054059 |
| 44 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.98188242 |
| 45 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.89664797 |
| 46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.85221866 |
| 47 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.85102346 |
| 48 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.84700194 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.84006993 |
| 50 | Carbon metabolism_Homo sapiens_hsa01200 | 0.81878796 |
| 51 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.81465440 |
| 52 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.78064299 |
| 53 | Thyroid cancer_Homo sapiens_hsa05216 | 0.75643655 |
| 54 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.75638581 |
| 55 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.64115895 |
| 56 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.62846441 |
| 57 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.62753963 |
| 58 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.62620997 |
| 59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.62533061 |
| 60 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.61636365 |
| 61 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60357888 |
| 62 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.57497535 |
| 63 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.54638239 |
| 64 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.53779846 |
| 65 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53317141 |
| 66 | * Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.50076182 |
| 67 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.48910732 |
| 68 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.48801582 |
| 69 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.48486149 |
| 70 | HTLV-I infection_Homo sapiens_hsa05166 | 0.44734850 |
| 71 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.44667253 |
| 72 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.41941030 |
| 73 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.38498698 |
| 74 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.37530092 |
| 75 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.37074862 |
| 76 | Huntingtons disease_Homo sapiens_hsa05016 | 0.36555503 |
| 77 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.36181931 |
| 78 | Galactose metabolism_Homo sapiens_hsa00052 | 0.35754093 |
| 79 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.35183896 |
| 80 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.34503803 |
| 81 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.32361599 |
| 82 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.32029863 |
| 83 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.31040333 |
| 84 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.30827784 |
| 85 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.30316837 |
| 86 | Sulfur relay system_Homo sapiens_hsa04122 | 0.28233917 |
| 87 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.27176620 |
| 88 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.26831036 |
| 89 | Retinol metabolism_Homo sapiens_hsa00830 | 0.26198552 |
| 90 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.24149100 |
| 91 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.23537105 |
| 92 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.23345575 |
| 93 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.22864736 |
| 94 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.22215339 |
| 95 | Phototransduction_Homo sapiens_hsa04744 | 0.20603010 |
| 96 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.20511835 |
| 97 | Apoptosis_Homo sapiens_hsa04210 | 0.20123993 |
| 98 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.19454947 |
| 99 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.18699936 |
| 100 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.18280357 |
| 101 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.18040538 |
| 102 | Legionellosis_Homo sapiens_hsa05134 | 0.18001974 |
| 103 | Colorectal cancer_Homo sapiens_hsa05210 | 0.17529463 |
| 104 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.16989098 |
| 105 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.16932389 |
| 106 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.16317729 |
| 107 | Tight junction_Homo sapiens_hsa04530 | 0.14442275 |
| 108 | Peroxisome_Homo sapiens_hsa04146 | 0.13674848 |
| 109 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.13324404 |
| 110 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.12938410 |
| 111 | Bladder cancer_Homo sapiens_hsa05219 | 0.10819075 |
| 112 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.10539772 |
| 113 | Pathways in cancer_Homo sapiens_hsa05200 | 0.10373624 |
| 114 | Nicotine addiction_Homo sapiens_hsa05033 | 0.09774143 |
| 115 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.09746642 |
| 116 | Alcoholism_Homo sapiens_hsa05034 | 0.09537167 |
| 117 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.08542587 |
| 118 | Taste transduction_Homo sapiens_hsa04742 | 0.08150150 |
| 119 | Adherens junction_Homo sapiens_hsa04520 | 0.07753549 |
| 120 | Prostate cancer_Homo sapiens_hsa05215 | 0.07251720 |
| 121 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.06313637 |
| 122 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.06171127 |
| 123 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.05098617 |
| 124 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.04148772 |
| 125 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.02858990 |
| 126 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.02522209 |
| 127 | Lysine degradation_Homo sapiens_hsa00310 | 0.01308480 |
| 128 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.01140530 |
| 129 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.01106185 |
| 130 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.00792014 |

