POLR3GL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)5.45406524
2cytidine deamination (GO:0009972)5.02162224
3cytidine metabolic process (GO:0046087)5.02162224
4cytidine catabolic process (GO:0006216)5.02162224
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.81043583
6regulation of autophagic vacuole assembly (GO:2000785)4.24070114
7polyketide metabolic process (GO:0030638)4.10395143
8doxorubicin metabolic process (GO:0044598)4.10395143
9daunorubicin metabolic process (GO:0044597)4.10395143
10Arp2/3 complex-mediated actin nucleation (GO:0034314)4.06499470
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.82368759
12positive regulation of gamma-delta T cell activation (GO:0046645)3.81468922
13regulation of vacuole organization (GO:0044088)3.69041178
14skeletal muscle contraction (GO:0003009)3.60290357
15actin nucleation (GO:0045010)3.49485105
16negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.49119279
17negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.45998549
18respiratory chain complex IV assembly (GO:0008535)3.41259488
19negative regulation of erythrocyte differentiation (GO:0045647)3.40439107
20negative T cell selection (GO:0043383)3.36411483
21negative regulation of granulocyte differentiation (GO:0030853)3.31471667
22protein complex biogenesis (GO:0070271)3.28033702
23cytochrome complex assembly (GO:0017004)3.27332817
24production of molecular mediator involved in inflammatory response (GO:0002532)3.26754861
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.25561237
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.25561237
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24587473
28response to interferon-beta (GO:0035456)3.21851871
29skeletal muscle adaptation (GO:0043501)3.21051033
30negative regulation of cell killing (GO:0031342)3.18977476
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18977476
32DNA deamination (GO:0045006)3.16886202
33cellular response to exogenous dsRNA (GO:0071360)3.12821751
34cellular response to type I interferon (GO:0071357)3.10150089
35type I interferon signaling pathway (GO:0060337)3.10150089
36response to type I interferon (GO:0034340)3.09877195
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09408706
38endosome to melanosome transport (GO:0035646)3.09285976
39endosome to pigment granule transport (GO:0043485)3.09285976
40lipoxygenase pathway (GO:0019372)3.08045893
41positive regulation of B cell differentiation (GO:0045579)3.07933231
42antigen processing and presentation via MHC class Ib (GO:0002475)3.07823011
43respiratory electron transport chain (GO:0022904)3.05317962
44lymph node development (GO:0048535)3.04087424
45regulation of B cell receptor signaling pathway (GO:0050855)3.03409191
46cellular response to interferon-beta (GO:0035458)3.02421196
47immunoglobulin mediated immune response (GO:0016064)3.00311295
48response to peptidoglycan (GO:0032494)2.98872392
49electron transport chain (GO:0022900)2.98316386
50regulation of regulatory T cell differentiation (GO:0045589)2.95614517
51positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95506866
52striated muscle atrophy (GO:0014891)2.95389833
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94766209
54muscle atrophy (GO:0014889)2.92218335
55negative thymic T cell selection (GO:0045060)2.90283750
56mitochondrial respiratory chain complex I assembly (GO:0032981)2.89898664
57NADH dehydrogenase complex assembly (GO:0010257)2.89898664
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89898664
59positive regulation of granulocyte differentiation (GO:0030854)2.84560945
60negative regulation of alpha-beta T cell differentiation (GO:0046639)2.83175426
61sulfate transmembrane transport (GO:1902358)2.82745812
62inositol phosphate catabolic process (GO:0071545)2.81873615
63negative regulation of cAMP-mediated signaling (GO:0043951)2.81592839
64negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.80190133
65regulation of antigen processing and presentation (GO:0002577)2.78684957
66positive T cell selection (GO:0043368)2.77725228
67mitochondrial respiratory chain complex assembly (GO:0033108)2.77201474
68phospholipid scrambling (GO:0017121)2.76684831
69negative regulation of protein tyrosine kinase activity (GO:0061099)2.73729290
70platelet dense granule organization (GO:0060155)2.73709690
71valine metabolic process (GO:0006573)2.73462466
72antigen processing and presentation of endogenous antigen (GO:0019883)2.72118693
73mitochondrial calcium ion homeostasis (GO:0051560)2.70293316
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70291626
75energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69967795
76ATP synthesis coupled proton transport (GO:0015986)2.69967795
77positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.69719272
78regulation of relaxation of muscle (GO:1901077)2.68756739
79purine-containing compound salvage (GO:0043101)2.68548961
80muscle filament sliding (GO:0030049)2.68446832
81actin-myosin filament sliding (GO:0033275)2.68446832
82negative regulation of T cell apoptotic process (GO:0070233)2.66852796
83oxidative phosphorylation (GO:0006119)2.65878041
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65642788
85adenosine metabolic process (GO:0046085)2.65546905
86superoxide anion generation (GO:0042554)2.65359842
87positive thymic T cell selection (GO:0045059)2.64593166
88germinal center formation (GO:0002467)2.64182761
89definitive hemopoiesis (GO:0060216)2.61494533
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.60545084
91mature B cell differentiation involved in immune response (GO:0002313)2.59740546
92sequestering of actin monomers (GO:0042989)2.59531615
93purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.56906116
94regulation of skeletal muscle contraction (GO:0014819)2.56307083
95defense response to protozoan (GO:0042832)2.55621215
96regulation of gamma-delta T cell differentiation (GO:0045586)2.55044507
97detection of molecule of bacterial origin (GO:0032490)2.54054471
98mitochondrial calcium ion transport (GO:0006851)2.53416187
99Peyers patch development (GO:0048541)2.53005837
100mucosal-associated lymphoid tissue development (GO:0048537)2.53005837
101pyrimidine nucleoside catabolic process (GO:0046135)2.52142997
102response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.51692799
103regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.50584698
104purine deoxyribonucleotide catabolic process (GO:0009155)2.50036700
105purine deoxyribonucleotide metabolic process (GO:0009151)2.49873313
106aggressive behavior (GO:0002118)2.49856136
107sulfate transport (GO:0008272)2.49201345
108interferon-gamma production (GO:0032609)2.49109411
109regulation of gamma-delta T cell activation (GO:0046643)2.48781688
110positive regulation of antigen processing and presentation (GO:0002579)2.48591508
111positive regulation of calcium-mediated signaling (GO:0050850)2.48230361
112regulation of sequestering of triglyceride (GO:0010889)2.47935411
113deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.46514854
114regulation of B cell differentiation (GO:0045577)2.45046777
115energy homeostasis (GO:0097009)2.44801898
116regulation of T cell mediated cytotoxicity (GO:0001914)2.44712561
117negative regulation of glycoprotein biosynthetic process (GO:0010561)2.44394968
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.43870930
119deoxyribonucleotide catabolic process (GO:0009264)2.43690293
120regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.43243521
121regulation of natural killer cell mediated immunity (GO:0002715)2.43243521
122NAD biosynthetic process (GO:0009435)2.43082821
123positive regulation of natural killer cell mediated immunity (GO:0002717)2.42736100
124deoxyribose phosphate catabolic process (GO:0046386)2.42556187
125aminoglycoside antibiotic metabolic process (GO:0030647)2.42287098
126ubiquinone biosynthetic process (GO:0006744)2.41262337
127G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.41256563
128mature B cell differentiation (GO:0002335)2.40392376
129phosphorylated carbohydrate dephosphorylation (GO:0046838)2.40275963
130inositol phosphate dephosphorylation (GO:0046855)2.40275963
131antigen receptor-mediated signaling pathway (GO:0050851)2.38436317
132negative regulation of calcium ion transmembrane transport (GO:1903170)2.38246439
133negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.38246439
134megakaryocyte development (GO:0035855)2.38088216
135seminiferous tubule development (GO:0072520)2.37245474
136iron-sulfur cluster assembly (GO:0016226)2.37033809
137metallo-sulfur cluster assembly (GO:0031163)2.37033809
138neutrophil activation involved in immune response (GO:0002283)2.35714221
139oligosaccharide catabolic process (GO:0009313)2.35482909
140regulation of hypersensitivity (GO:0002883)2.34891273
141positive regulation of mast cell activation involved in immune response (GO:0033008)2.34846421
142positive regulation of mast cell degranulation (GO:0043306)2.34846421
143regulation of T cell receptor signaling pathway (GO:0050856)2.34614176
144purine nucleotide salvage (GO:0032261)2.34190705
145T cell receptor signaling pathway (GO:0050852)2.33621649
146positive regulation of protein sumoylation (GO:0033235)2.33202496
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.32217769
148response to interferon-alpha (GO:0035455)2.32208982
149nucleoside diphosphate catabolic process (GO:0009134)2.31912886
150regulation of alpha-beta T cell proliferation (GO:0046640)2.31253083
151positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.31045058
152protein-cofactor linkage (GO:0018065)2.30985306
153GPI anchor biosynthetic process (GO:0006506)2.29677386
154negative regulation of myotube differentiation (GO:0010832)2.28719940
155B cell mediated immunity (GO:0019724)2.28622868
156positive regulation of interleukin-4 production (GO:0032753)2.28369548
157positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.28313486
158preassembly of GPI anchor in ER membrane (GO:0016254)2.28139255
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.28005866
160negative regulation of nitric-oxide synthase activity (GO:0051001)2.27360527
161T cell migration (GO:0072678)2.26342562
162mast cell activation (GO:0045576)2.26155667
163negative regulation of viral genome replication (GO:0045071)2.24932879
164regulation of cell communication by electrical coupling (GO:0010649)2.24176961
165sarcoplasmic reticulum calcium ion transport (GO:0070296)2.24009185
166regulation of vitamin metabolic process (GO:0030656)2.23496757
167response to protozoan (GO:0001562)2.22868729
168detection of other organism (GO:0098543)2.22630421
169dendritic cell chemotaxis (GO:0002407)2.21943935
170negative regulation of innate immune response (GO:0045824)2.21347416
171regulation of granulocyte differentiation (GO:0030852)2.20665477
172positive regulation of tumor necrosis factor production (GO:0032760)2.20148849
173positive regulation of respiratory burst (GO:0060267)2.20055558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.60734561
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.42428978
3SCL_19346495_ChIP-Seq_HPC-7_Human4.05376641
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.47273585
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.41743643
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32401560
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.31203875
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14457332
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10245014
10MEIS1_20887958_ChIP-Seq_HPC-7_Mouse3.01521991
11FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.88374841
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84534644
13LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.74166424
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.70726853
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.57151431
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54840102
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43460481
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42835047
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39549918
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.31854702
21VDR_23849224_ChIP-Seq_CD4+_Human2.27313175
22* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26166197
23* GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.22303421
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17108676
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14748496
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13028203
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11905492
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06324129
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02058169
30* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00289363
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97816476
32* IRF8_27001747_Chip-Seq_BMDM_Mouse1.96387554
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.94610097
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.88455548
35GATA1_22025678_ChIP-Seq_K562_Human1.79786576
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.77606460
37* SPI1_23547873_ChIP-Seq_NB4_Human1.76864068
38RUNX_20019798_ChIP-Seq_JUKART_Human1.75396553
39SPI1_23127762_ChIP-Seq_K562_Human1.74209693
40VDR_21846776_ChIP-Seq_THP-1_Human1.72053742
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.71930669
42* GATA1_19941827_ChIP-Seq_MEL_Mouse1.69272244
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68922690
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67592085
45VDR_24763502_ChIP-Seq_THP-1_Human1.67335450
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67068280
47FOXP3_21729870_ChIP-Seq_TREG_Human1.66601855
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66413240
49* SRF_21415370_ChIP-Seq_HL-1_Mouse1.65457511
50ZNF274_21170338_ChIP-Seq_K562_Hela1.59458774
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58718690
52* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58655633
53GATA3_26560356_Chip-Seq_TH2_Human1.56402886
54* MAF_26560356_Chip-Seq_TH1_Human1.53434644
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.53336649
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52674439
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48972010
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44663269
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42558439
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42501832
61HTT_18923047_ChIP-ChIP_STHdh_Human1.41341717
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37940613
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37101846
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36731044
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.36664981
66VDR_22108803_ChIP-Seq_LS180_Human1.35028040
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34954525
68BCL6_27268052_Chip-Seq_Bcells_Human1.34636976
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34604226
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33715382
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33425618
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32790155
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31951279
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.30498753
75TP53_22573176_ChIP-Seq_HFKS_Human1.29274499
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27912082
77BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.27574271
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26953010
79* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26845632
80EZH2_22144423_ChIP-Seq_EOC_Human1.25975060
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25224798
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23215586
83ELK1_19687146_ChIP-ChIP_HELA_Human1.22566692
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22078034
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20250264
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20126794
87MAF_26560356_Chip-Seq_TH2_Human1.16762799
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16086449
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16084335
90AR_20517297_ChIP-Seq_VCAP_Human1.15296263
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15185284
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14957460
93* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14934480
94MYB_26560356_Chip-Seq_TH1_Human1.14682278
95MYB_26560356_Chip-Seq_TH2_Human1.12628042
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12597157
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.12537840
98* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12045521
99* UTX_26944678_Chip-Seq_JUKART_Human1.12031431
100* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11998816
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11921594
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11197430
103MYC_18940864_ChIP-ChIP_HL60_Human1.09612204
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08776234
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06942380
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06359412
107* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06100952
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05597921
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05142949
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03923021
111CIITA_25753668_ChIP-Seq_RAJI_Human1.03391687
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02482419
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02208721
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01870656
115BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01676373
116ER_23166858_ChIP-Seq_MCF-7_Human1.01602875
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00918736
118GABP_19822575_ChIP-Seq_HepG2_Human1.00303381
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00194535
120MYC_22102868_ChIP-Seq_BL_Human0.99843229
121FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99370690
122FOXA1_25329375_ChIP-Seq_VCAP_Human0.99370690
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.99247383
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99110369
125STAT1_20625510_ChIP-Seq_HELA_Human0.98642147
126PU_27001747_Chip-Seq_BMDM_Mouse0.98065335
127GATA3_27048872_Chip-Seq_THYMUS_Human0.95396987
128* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95128273
129ELF1_20517297_ChIP-Seq_JURKAT_Human0.94755837
130SPI1_20517297_ChIP-Seq_HL60_Human0.94499022
131LXR_22292898_ChIP-Seq_THP-1_Human0.93860645
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93462923
133EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93086868
134P300_27268052_Chip-Seq_Bcells_Human0.92494255
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91455045
136ERG_20517297_ChIP-Seq_VCAP_Human0.91004537
137IGF1R_20145208_ChIP-Seq_DFB_Human0.90866636
138FLI1_27457419_Chip-Seq_LIVER_Mouse0.90311796
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90096321
140TCF7_22412390_ChIP-Seq_EML_Mouse0.88496467
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88405497
142CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88097743
143GATA3_26560356_Chip-Seq_TH1_Human0.87794081
144CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87589861
145PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85965250
146P68_20966046_ChIP-Seq_HELA_Human0.85807280
147TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85802708
148ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85181722
149RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84707720
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.84085446
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.83416290
152CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83223391
153NANOG_20526341_ChIP-Seq_ESCs_Human0.83032589
154CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82870175
155BCOR_27268052_Chip-Seq_Bcells_Human0.82565280
156TAF2_19829295_ChIP-Seq_ESCs_Human0.82143187
157NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81628549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.38705584
2MP0003646_muscle_fatigue3.09110308
3MP0006292_abnormal_olfactory_placode2.99359298
4MP0002837_dystrophic_cardiac_calcinosis2.83867038
5MP0001835_abnormal_antigen_presentation2.83699826
6MP0002148_abnormal_hypersensitivity_rea2.66580004
7MP0003724_increased_susceptibility_to2.59937878
8MP0009785_altered_susceptibility_to2.41915317
9MP0005671_abnormal_response_to2.35876215
10MP0000685_abnormal_immune_system2.30562518
11MP0000013_abnormal_adipose_tissue2.29212261
12MP0003283_abnormal_digestive_organ2.18556186
13MP0001986_abnormal_taste_sensitivity2.10550841
14MP0000749_muscle_degeneration2.08882836
15MP0005025_abnormal_response_to1.97832441
16MP0005645_abnormal_hypothalamus_physiol1.97621111
17MP0004130_abnormal_muscle_cell1.88013706
18MP0001790_abnormal_immune_system1.87515906
19MP0005387_immune_system_phenotype1.87515906
20MP0006082_CNS_inflammation1.85417736
21MP0003436_decreased_susceptibility_to1.78048771
22MP0001800_abnormal_humoral_immune1.77724539
23MP0002419_abnormal_innate_immunity1.77697709
24MP0000372_irregular_coat_pigmentation1.77496574
25MP0005000_abnormal_immune_tolerance1.77196225
26MP0002723_abnormal_immune_serum1.68640364
27MP0002234_abnormal_pharynx_morphology1.66021005
28MP0003186_abnormal_redox_activity1.65732967
29MP0002420_abnormal_adaptive_immunity1.65606992
30MP0001819_abnormal_immune_cell1.65476316
31MP0002396_abnormal_hematopoietic_system1.64870349
32MP0002452_abnormal_antigen_presenting1.64019610
33MP0009333_abnormal_splenocyte_physiolog1.63044962
34MP0005464_abnormal_platelet_physiology1.62676566
35MP0003183_abnormal_peptide_metabolism1.61613744
36MP0000751_myopathy1.55487283
37MP0003806_abnormal_nucleotide_metabolis1.52754444
38MP0004142_abnormal_muscle_tone1.47756157
39MP0010386_abnormal_urinary_bladder1.46875646
40MP0006036_abnormal_mitochondrial_physio1.44296854
41MP0005075_abnormal_melanosome_morpholog1.40942299
42MP0002102_abnormal_ear_morphology1.39735104
43MP0002822_catalepsy1.39348887
44MP0005084_abnormal_gallbladder_morpholo1.38808311
45MP0004036_abnormal_muscle_relaxation1.37786330
46MP0008875_abnormal_xenobiotic_pharmacok1.37041441
47MP0002398_abnormal_bone_marrow1.36338369
48MP0001905_abnormal_dopamine_level1.34758924
49MP0000343_altered_response_to1.34757958
50MP0005174_abnormal_tail_pigmentation1.32815683
51MP0000015_abnormal_ear_pigmentation1.27292551
52MP0003866_abnormal_defecation1.27043161
53MP0004145_abnormal_muscle_electrophysio1.25405617
54MP0002638_abnormal_pupillary_reflex1.24985514
55MP0003763_abnormal_thymus_physiology1.24487815
56MP0000716_abnormal_immune_system1.24219387
57MP0001853_heart_inflammation1.22225510
58MP0001188_hyperpigmentation1.21279477
59MP0002132_abnormal_respiratory_system1.21167081
60MP0005058_abnormal_lysosome_morphology1.20745243
61MP0008469_abnormal_protein_level1.20731373
62MP0004147_increased_porphyrin_level1.20347174
63MP0005167_abnormal_blood-brain_barrier1.20229066
64MP0005646_abnormal_pituitary_gland1.19822280
65MP0003045_fibrosis1.18390141
66MP0001845_abnormal_inflammatory_respons1.18254970
67MP0003191_abnormal_cellular_cholesterol1.17759574
68MP0009764_decreased_sensitivity_to1.17681890
69MP0000678_abnormal_parathyroid_gland1.17541867
70MP0000689_abnormal_spleen_morphology1.15030454
71MP0010155_abnormal_intestine_physiology1.13815841
72MP0004808_abnormal_hematopoietic_stem1.12695637
73MP0002405_respiratory_system_inflammati1.12499636
74MP0005535_abnormal_body_temperature1.12389558
75MP0004215_abnormal_myocardial_fiber1.11982513
76MP0002138_abnormal_hepatobiliary_system1.11930805
77MP0002693_abnormal_pancreas_physiology1.11452587
78MP0003656_abnormal_erythrocyte_physiolo1.11289769
79MP0005666_abnormal_adipose_tissue1.10523745
80MP0002429_abnormal_blood_cell1.09371745
81MP0005379_endocrine/exocrine_gland_phen1.05589391
82MP0005334_abnormal_fat_pad1.05378636
83MP0004084_abnormal_cardiac_muscle1.05122010
84MP0002722_abnormal_immune_system1.05098572
85MP0002139_abnormal_hepatobiliary_system1.04585484
86MP0002106_abnormal_muscle_physiology1.03565915
87MP0008877_abnormal_DNA_methylation1.02407187
88MP0003828_pulmonary_edema1.02058786
89MP0009763_increased_sensitivity_to1.00005712
90MP0000569_abnormal_digit_pigmentation0.99957597
91MP0002928_abnormal_bile_duct0.98928733
92MP0000703_abnormal_thymus_morphology0.98590861
93MP0003279_aneurysm0.96011150
94MP0003172_abnormal_lysosome_physiology0.93990736
95MP0006072_abnormal_retinal_apoptosis0.93968471
96MP0005266_abnormal_metabolism0.92499110
97MP0002006_tumorigenesis0.91459639
98MP0002078_abnormal_glucose_homeostasis0.91194905
99MP0006276_abnormal_autonomic_nervous0.87953592
100MP0003252_abnormal_bile_duct0.87838866
101MP0003011_delayed_dark_adaptation0.87732969
102MP0002933_joint_inflammation0.87676032
103MP0001944_abnormal_pancreas_morphology0.86449701
104MP0003303_peritoneal_inflammation0.85875888
105MP0009115_abnormal_fat_cell0.84720393
106MP0000681_abnormal_thyroid_gland0.84217086
107MP0005375_adipose_tissue_phenotype0.83783772
108MP0002166_altered_tumor_susceptibility0.83741230
109MP0003195_calcinosis0.83451740
110MP0002876_abnormal_thyroid_physiology0.81992818
111MP0005636_abnormal_mineral_homeostasis0.81816502
112MP0000465_gastrointestinal_hemorrhage0.81271193
113MP0000003_abnormal_adipose_tissue0.81048837
114MP0004782_abnormal_surfactant_physiolog0.80721660
115MP0002998_abnormal_bone_remodeling0.80609256
116MP0002909_abnormal_adrenal_gland0.80427234
117MP0005397_hematopoietic_system_phenotyp0.79910279
118MP0001545_abnormal_hematopoietic_system0.79910279
119MP0003880_abnormal_central_pattern0.79505127
120MP0001533_abnormal_skeleton_physiology0.79443996
121MP0001765_abnormal_ion_homeostasis0.79426990
122MP0009278_abnormal_bone_marrow0.79391714
123MP0008004_abnormal_stomach_pH0.79358712
124MP0003787_abnormal_imprinting0.79337073
125MP0001764_abnormal_homeostasis0.79179344
126MP0005253_abnormal_eye_physiology0.79002488
127MP0005551_abnormal_eye_electrophysiolog0.78983433
128MP0006035_abnormal_mitochondrial_morpho0.78628770
129MP0008058_abnormal_DNA_repair0.78099639
130MP0008995_early_reproductive_senescence0.77339088
131MP0008775_abnormal_heart_ventricle0.76930007
132MP0001542_abnormal_bone_strength0.76273826
133MP0005584_abnormal_enzyme/coenzyme_acti0.76131179
134MP0008872_abnormal_physiological_respon0.75852532
135MP0001968_abnormal_touch/_nociception0.75582030
136MP0005376_homeostasis/metabolism_phenot0.75515686
137MP0005360_urolithiasis0.74436586
138MP0002163_abnormal_gland_morphology0.73771734
139MP0002653_abnormal_ependyma_morphology0.73134093
140MP0010329_abnormal_lipoprotein_level0.73072612

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)3.89555038
2Acute necrotizing encephalopathy (HP:0006965)3.83934882
3Abnormal mitochondria in muscle tissue (HP:0008316)3.63085893
4Progressive macrocephaly (HP:0004481)3.48513746
5Increased CSF lactate (HP:0002490)3.47153197
6Exercise-induced myalgia (HP:0003738)3.42129823
7Vacuolated lymphocytes (HP:0001922)3.30460994
8Acute encephalopathy (HP:0006846)3.19206222
9Prolonged bleeding time (HP:0003010)3.18434421
10Recurrent bacterial skin infections (HP:0005406)3.13282719
113-Methylglutaconic aciduria (HP:0003535)3.05292922
12Exertional dyspnea (HP:0002875)2.97299400
13Petechiae (HP:0000967)2.95631366
14Stomatitis (HP:0010280)2.93885622
15Abnormality of the heme biosynthetic pathway (HP:0010472)2.92692008
16Hypothermia (HP:0002045)2.90357655
17Aplastic anemia (HP:0001915)2.88609280
18Renal Fanconi syndrome (HP:0001994)2.83258281
19Increased muscle lipid content (HP:0009058)2.83044942
20Abnormality of B cell number (HP:0010975)2.80997776
21B lymphocytopenia (HP:0010976)2.75356877
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.73073731
23Asymmetric septal hypertrophy (HP:0001670)2.70358287
24Cerebral edema (HP:0002181)2.68919352
25Increased hepatocellular lipid droplets (HP:0006565)2.68175342
26Posterior subcapsular cataract (HP:0007787)2.68013695
27Increased intramyocellular lipid droplets (HP:0012240)2.67448068
28Abnormal rod and cone electroretinograms (HP:0008323)2.66381584
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64488693
30Severe visual impairment (HP:0001141)2.63908716
31Lipid accumulation in hepatocytes (HP:0006561)2.62073920
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.61546754
33Respiratory failure (HP:0002878)2.60994228
34Abnormality of the prostate (HP:0008775)2.60668092
35Generalized aminoaciduria (HP:0002909)2.55573259
36Myositis (HP:0100614)2.54705451
37Abnormality of glycolipid metabolism (HP:0010969)2.52227390
38Abnormality of liposaccharide metabolism (HP:0010968)2.52227390
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.52227390
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49242362
41Abnormality of alanine metabolism (HP:0010916)2.49242362
42Hyperalaninemia (HP:0003348)2.49242362
43Increased IgM level (HP:0003496)2.49229117
44Myoglobinuria (HP:0002913)2.49036221
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48623705
46Lactic acidosis (HP:0003128)2.47892682
47Hepatic necrosis (HP:0002605)2.46271535
48Eczematoid dermatitis (HP:0000976)2.43555927
49IgM deficiency (HP:0002850)2.41108759
50Hypoproteinemia (HP:0003075)2.40138876
51Oligomenorrhea (HP:0000876)2.39521874
52IgG deficiency (HP:0004315)2.37338433
53T lymphocytopenia (HP:0005403)2.37186919
54Renal cortical cysts (HP:0000803)2.36716518
55Elevated erythrocyte sedimentation rate (HP:0003565)2.35987735
56Systemic lupus erythematosus (HP:0002725)2.35714270
57Chronic obstructive pulmonary disease (HP:0006510)2.32374598
58Obstructive lung disease (HP:0006536)2.32374598
59Autoimmune hemolytic anemia (HP:0001890)2.32028728
60Granulocytopenia (HP:0001913)2.31729124
61Panhypogammaglobulinemia (HP:0003139)2.31047428
62Dicarboxylic aciduria (HP:0003215)2.30529931
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30529931
64Nemaline bodies (HP:0003798)2.30498519
65Albinism (HP:0001022)2.29811235
66Encephalitis (HP:0002383)2.29775104
67Acute hepatic failure (HP:0006554)2.27897072
68Abnormality of T cell number (HP:0011839)2.26347350
69Eosinophilia (HP:0001880)2.24865067
70Recurrent skin infections (HP:0001581)2.24629251
71Decreased circulating renin level (HP:0003351)2.24578603
72CNS demyelination (HP:0007305)2.23961545
73Recurrent cutaneous fungal infections (HP:0011370)2.23832582
74Chronic mucocutaneous candidiasis (HP:0002728)2.23832582
75Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22856955
76Combined immunodeficiency (HP:0005387)2.22466661
77Hypoglycemic coma (HP:0001325)2.21454873
78Late onset (HP:0003584)2.21016313
79Increased serum lactate (HP:0002151)2.18961110
80Recurrent fungal infections (HP:0002841)2.18938215
81Rhabdomyolysis (HP:0003201)2.17868380
82Optic disc pallor (HP:0000543)2.17716883
83Chronic diarrhea (HP:0002028)2.17220298
84Abnormality of macular pigmentation (HP:0008002)2.17087682
85Exercise intolerance (HP:0003546)2.16933889
86Abnormality of renal resorption (HP:0011038)2.16543541
87Ventricular tachycardia (HP:0004756)2.15894368
88Congenital stationary night blindness (HP:0007642)2.15521148
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15471973
90Type 2 muscle fiber atrophy (HP:0003554)2.15428510
91Amyotrophic lateral sclerosis (HP:0007354)2.15317970
92Abnormality of T cells (HP:0002843)2.15279880
93Calf muscle hypertrophy (HP:0008981)2.15040853
94Exercise-induced muscle cramps (HP:0003710)2.14837182
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13499436
96Subaortic stenosis (HP:0001682)2.11125243
97Abnormality of the left ventricular outflow tract (HP:0011103)2.11125243
98Meningitis (HP:0001287)2.11027855
99Gingivitis (HP:0000230)2.10294672
100Thyroiditis (HP:0100646)2.09456255
101Prostate neoplasm (HP:0100787)2.09064100
102Gastrointestinal infarctions (HP:0005244)2.08922549
103Dysostosis multiplex (HP:0000943)2.08389350
104Hypochromic microcytic anemia (HP:0004840)2.08081635
105Muscle hypertrophy of the lower extremities (HP:0008968)2.06187521
106Muscle fiber inclusion bodies (HP:0100299)2.05253299
107Reduced antithrombin III activity (HP:0001976)2.05072462
108Hepatocellular necrosis (HP:0001404)2.04400035
109Abnormality of eosinophils (HP:0001879)2.04388167
110Abnormality of T cell physiology (HP:0011840)2.03227782
111Breech presentation (HP:0001623)2.01614180
112Emotional lability (HP:0000712)2.00212392
113Toxemia of pregnancy (HP:0100603)1.99638375
114Flat capital femoral epiphysis (HP:0003370)1.99222408
115Abnormality of macrophages (HP:0004311)1.98973955
116Insulin-resistant diabetes mellitus (HP:0000831)1.98684627
117Large for gestational age (HP:0001520)1.98211778
118Myotonia (HP:0002486)1.97406161
119Type I transferrin isoform profile (HP:0003642)1.96314402
120Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.94979728
121Progressive microcephaly (HP:0000253)1.94270287
122Muscle stiffness (HP:0003552)1.93719830
123Methylmalonic acidemia (HP:0002912)1.92906037
124Agammaglobulinemia (HP:0004432)1.92900526
125Distal arthrogryposis (HP:0005684)1.92813597
126Spastic paraparesis (HP:0002313)1.92117284
127Medial flaring of the eyebrow (HP:0010747)1.91675975
128Mitochondrial inheritance (HP:0001427)1.91337256
129Pancreatic cysts (HP:0001737)1.90224658
130Abnormality of calcium-phosphate metabolism (HP:0100530)1.89654053
131Cerebral palsy (HP:0100021)1.89096507
132Severe combined immunodeficiency (HP:0004430)1.87092609
133Large eyes (HP:0001090)1.86790465
134Epistaxis (HP:0000421)1.86416849
135Progressive neurologic deterioration (HP:0002344)1.86399874
136Muscle fiber atrophy (HP:0100295)1.85462277
137Recurrent gram-negative bacterial infections (HP:0005420)1.85440191
138Lipoatrophy (HP:0100578)1.85090113
139Abnormal hemoglobin (HP:0011902)1.84979932
140Inflammation of the large intestine (HP:0002037)1.83373900
141Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83282319
142Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83282319
143Atrophy/Degeneration involving motor neurons (HP:0007373)1.82249773
144Orchitis (HP:0100796)1.80764985
145Attenuation of retinal blood vessels (HP:0007843)1.80137629
146Abnormality of polysaccharide metabolism (HP:0011012)1.79955525
147Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79955525
148Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79955525
149Retrobulbar optic neuritis (HP:0100654)1.79604093
150Optic neuritis (HP:0100653)1.79604093
151Glycosuria (HP:0003076)1.79210200
152Abnormality of urine glucose concentration (HP:0011016)1.79210200
153Gastrointestinal inflammation (HP:0004386)1.78798891
154Dilated cardiomyopathy (HP:0001644)1.78143785
155Microcytic anemia (HP:0001935)1.78093815
156Metaphyseal dysplasia (HP:0100255)1.77444329
157Nonprogressive disorder (HP:0003680)1.77332191
158Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.77259372
159Abnormality of the renal cortex (HP:0011035)1.76897272
160Abnormality of iron homeostasis (HP:0011031)1.76329404
161Abnormal platelet function (HP:0011869)1.76001794
162Impaired platelet aggregation (HP:0003540)1.76001794
163Constricted visual fields (HP:0001133)1.74755733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.84015718
2INSRR3.05845381
3TESK22.90549594
4IRAK42.70212753
5MAPKAPK32.54087317
6FLT32.26017268
7PIK3CA2.20375624
8BLK2.17820046
9KIT2.13967304
10MAPK152.07598253
11IRAK32.07021611
12TGFBR21.95447015
13TNIK1.92201089
14ERBB31.89089949
15TESK11.82949998
16PIK3CG1.82411411
17IRAK11.80271386
18FRK1.78872623
19BTK1.72479430
20FES1.71280405
21NUAK11.69460768
22MAPK131.68984123
23CSNK1G31.62535483
24TEC1.61312901
25LIMK11.56974869
26MAP3K141.54156031
27EPHB21.52550060
28GRK71.50792994
29MST1R1.47071941
30TIE11.46691957
31TXK1.37449033
32JAK31.37207840
33SCYL21.36053387
34MAP4K21.35946092
35SIK31.33629963
36MAP4K11.33427190
37GRK61.32813678
38OBSCN1.31736619
39CSNK1G21.29196043
40ZAK1.29070964
41NME21.28877876
42MAP3K111.26516150
43IKBKE1.26360051
44TYK21.25532005
45ADRBK21.20836080
46VRK21.18014039
47BCKDK1.17871500
48ZAP701.15968871
49PHKG11.13303604
50PHKG21.13303604
51IRAK21.11173988
52TRPM71.10814588
53RIPK11.10589157
54RIPK41.09787109
55MUSK1.08986447
56TRIM281.08232804
57STK161.07777216
58PRPF4B1.01241629
59TBK11.00913729
60MST41.00380018
61CSNK1G10.99822248
62MYLK0.99678734
63PINK10.99470802
64PRKCQ0.97226726
65DAPK10.96748942
66NEK90.95327211
67CSF1R0.94380863
68SYK0.92676128
69MAP2K30.91851686
70TTN0.90898391
71CSNK1A1L0.88855801
72CDK190.88059871
73TLK10.86367712
74MAP2K20.85882243
75TAOK20.85372564
76MAP3K40.85100032
77NLK0.84668118
78NME10.84527544
79BMPR20.84434010
80PIM20.82567130
81MAP3K130.82401447
82EIF2AK30.81079809
83MAPK110.80477574
84IKBKB0.77698966
85BCR0.77016931
86LYN0.75841159
87MAP3K120.73924599
88PRKD20.73871743
89MAP3K50.73304990
90ITK0.71686749
91RPS6KA40.70940191
92YES10.70140768
93PTK2B0.69932228
94CLK10.69829177
95ERN10.69150586
96MARK30.68587465
97EPHA30.68439649
98MATK0.67511402
99CAMKK20.66186636
100LCK0.65921974
101DAPK20.64901393
102GRK50.64176498
103EIF2AK20.63618444
104RAF10.62106914
105CAMK1D0.61832154
106JAK10.61723109
107MAPK120.61603902
108MAP2K70.61331080
109VRK10.58724963
110EIF2AK10.58613940
111MAPK70.56557827
112SIK10.56199488
113CCNB10.55174181
114RPS6KC10.54923858
115RPS6KL10.54923858
116MAPKAPK50.54533013
117GRK10.54357463
118CSK0.53587190
119RPS6KA60.53361943
120PKN20.53231618
121CAMK10.52946224
122RPS6KA50.52250999
123ADRBK10.50281760
124BMPR1B0.49713255
125MAP3K70.49684672
126WNK30.49117907
127ABL10.49015910
128PKN10.48658082
129JAK20.47388859
130PRKAA20.44766078
131MAP2K60.43816391
132HIPK20.43776639
133OXSR10.43339050
134ABL20.42759273
135CAMKK10.42608516
136TNK20.41246817
137MAP3K10.41192900
138PDK20.40919588
139PRKCE0.40639636
140ARAF0.39547587
141IGF1R0.38949978
142CHUK0.38479342
143KDR0.38051596
144HCK0.37987643
145MOS0.37946283
146TGFBR10.37574895
147PASK0.37118398
148PTK60.36813779
149CDK80.36427197
150MAPK40.34920347

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.35259433
2Graft-versus-host disease_Homo sapiens_hsa053322.97286261
3Caffeine metabolism_Homo sapiens_hsa002322.86260610
4Type I diabetes mellitus_Homo sapiens_hsa049402.65886708
5Autoimmune thyroid disease_Homo sapiens_hsa053202.63181294
6Asthma_Homo sapiens_hsa053102.51245287
7Primary immunodeficiency_Homo sapiens_hsa053402.48746616
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.47480105
9Fatty acid elongation_Homo sapiens_hsa000622.47167580
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.46908622
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.31938049
12Proteasome_Homo sapiens_hsa030502.15128655
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13777082
14Sulfur relay system_Homo sapiens_hsa041221.97195982
15Leishmaniasis_Homo sapiens_hsa051401.95070652
16Staphylococcus aureus infection_Homo sapiens_hsa051501.78298650
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76483555
18Protein export_Homo sapiens_hsa030601.75779609
19Sulfur metabolism_Homo sapiens_hsa009201.73136317
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68611751
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61665565
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.58575042
23Phototransduction_Homo sapiens_hsa047441.55378130
24Oxidative phosphorylation_Homo sapiens_hsa001901.53285359
25Measles_Homo sapiens_hsa051621.52335094
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48446304
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47269389
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46573185
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44720873
30Viral myocarditis_Homo sapiens_hsa054161.44067107
31* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43917564
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43074089
33Hematopoietic cell lineage_Homo sapiens_hsa046401.42928178
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.42905081
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41486285
36Butanoate metabolism_Homo sapiens_hsa006501.40852660
37Parkinsons disease_Homo sapiens_hsa050121.36165469
38B cell receptor signaling pathway_Homo sapiens_hsa046621.34000622
39Galactose metabolism_Homo sapiens_hsa000521.33696299
40Osteoclast differentiation_Homo sapiens_hsa043801.33577958
41Acute myeloid leukemia_Homo sapiens_hsa052211.31842014
42Fatty acid degradation_Homo sapiens_hsa000711.27377971
43Cardiac muscle contraction_Homo sapiens_hsa042601.21787249
44Lysosome_Homo sapiens_hsa041421.19716643
45Arachidonic acid metabolism_Homo sapiens_hsa005901.19499818
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.19476028
47Alzheimers disease_Homo sapiens_hsa050101.15331605
48Collecting duct acid secretion_Homo sapiens_hsa049661.11687536
49Pertussis_Homo sapiens_hsa051331.09852170
50Herpes simplex infection_Homo sapiens_hsa051681.08625418
51Propanoate metabolism_Homo sapiens_hsa006401.08607271
52Base excision repair_Homo sapiens_hsa034101.08454756
53ABC transporters_Homo sapiens_hsa020101.06668885
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06124955
55Starch and sucrose metabolism_Homo sapiens_hsa005001.05200875
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04639971
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03966454
58beta-Alanine metabolism_Homo sapiens_hsa004101.01313797
59Ribosome_Homo sapiens_hsa030100.94537036
60Regulation of autophagy_Homo sapiens_hsa041400.93119194
61Insulin secretion_Homo sapiens_hsa049110.90951910
62Pentose phosphate pathway_Homo sapiens_hsa000300.89634218
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89054597
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.87516630
65Legionellosis_Homo sapiens_hsa051340.85857791
66Shigellosis_Homo sapiens_hsa051310.85604830
67Influenza A_Homo sapiens_hsa051640.84785924
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83741616
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83672639
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83478479
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80173861
72Allograft rejection_Homo sapiens_hsa053300.79876529
73Insulin signaling pathway_Homo sapiens_hsa049100.75858728
74Dilated cardiomyopathy_Homo sapiens_hsa054140.75624618
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72196758
76Phagosome_Homo sapiens_hsa041450.71996062
77Type II diabetes mellitus_Homo sapiens_hsa049300.71942418
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71828179
79Apoptosis_Homo sapiens_hsa042100.71794732
80Toxoplasmosis_Homo sapiens_hsa051450.71414300
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70632498
82Circadian rhythm_Homo sapiens_hsa047100.70627824
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70442247
84N-Glycan biosynthesis_Homo sapiens_hsa005100.69217355
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68444006
86TNF signaling pathway_Homo sapiens_hsa046680.68364170
87Tuberculosis_Homo sapiens_hsa051520.67440718
88Huntingtons disease_Homo sapiens_hsa050160.66507111
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65168660
90Chemical carcinogenesis_Homo sapiens_hsa052040.64743182
91Platelet activation_Homo sapiens_hsa046110.62722441
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61968557
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61859379
94Chemokine signaling pathway_Homo sapiens_hsa040620.60883256
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60241985
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60102282
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59559451
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59029950
99Nitrogen metabolism_Homo sapiens_hsa009100.58119467
100Malaria_Homo sapiens_hsa051440.57726388
101Olfactory transduction_Homo sapiens_hsa047400.57396604
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56268188
103Chronic myeloid leukemia_Homo sapiens_hsa052200.55985330
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.55702934
105Non-homologous end-joining_Homo sapiens_hsa034500.55130379
106Fatty acid metabolism_Homo sapiens_hsa012120.54983030
107Tryptophan metabolism_Homo sapiens_hsa003800.54487294
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54198212
109PPAR signaling pathway_Homo sapiens_hsa033200.52396407
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50112558
111Hepatitis C_Homo sapiens_hsa051600.49689024
112Homologous recombination_Homo sapiens_hsa034400.49652095
113Fructose and mannose metabolism_Homo sapiens_hsa000510.49623973
114Antigen processing and presentation_Homo sapiens_hsa046120.46734688
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.46424739
116* Metabolic pathways_Homo sapiens_hsa011000.46390111
117Salmonella infection_Homo sapiens_hsa051320.45607708
118Peroxisome_Homo sapiens_hsa041460.45317700
119* Pyrimidine metabolism_Homo sapiens_hsa002400.45297763
120Prolactin signaling pathway_Homo sapiens_hsa049170.44920377
121RNA degradation_Homo sapiens_hsa030180.44583577
122T cell receptor signaling pathway_Homo sapiens_hsa046600.44371620
123Sphingolipid metabolism_Homo sapiens_hsa006000.44333411
124Rheumatoid arthritis_Homo sapiens_hsa053230.43808515
125* Purine metabolism_Homo sapiens_hsa002300.43649699
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43334640
127Fanconi anemia pathway_Homo sapiens_hsa034600.42803873
128Folate biosynthesis_Homo sapiens_hsa007900.42579753
129Ovarian steroidogenesis_Homo sapiens_hsa049130.42320590
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.41990479
131Calcium signaling pathway_Homo sapiens_hsa040200.41849199
132* RNA polymerase_Homo sapiens_hsa030200.41837507
133Linoleic acid metabolism_Homo sapiens_hsa005910.40102333
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39255710
135Glucagon signaling pathway_Homo sapiens_hsa049220.39085310
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38655588
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36358384
138Tyrosine metabolism_Homo sapiens_hsa003500.30023250
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29623223
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29387211
141Glutathione metabolism_Homo sapiens_hsa004800.27913216
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27643339

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