POLR3H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.04414259
2viral transcription (GO:0019083)5.12283902
3ribosomal small subunit biogenesis (GO:0042274)4.99867831
4translational termination (GO:0006415)4.98604866
5GDP-mannose metabolic process (GO:0019673)4.96414354
6proteasome assembly (GO:0043248)4.84799518
7maturation of SSU-rRNA (GO:0030490)4.44726953
8ribosomal large subunit biogenesis (GO:0042273)4.43225383
9pseudouridine synthesis (GO:0001522)4.42242506
10cotranslational protein targeting to membrane (GO:0006613)4.42209570
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.41337407
12translational elongation (GO:0006414)4.39722555
13DNA strand elongation involved in DNA replication (GO:0006271)4.38073959
14protein targeting to ER (GO:0045047)4.36517143
15ribosomal small subunit assembly (GO:0000028)4.25600776
16translational initiation (GO:0006413)4.23608984
17DNA replication initiation (GO:0006270)4.20051004
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18667047
19protein localization to endoplasmic reticulum (GO:0070972)4.17278509
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.16671745
21DNA strand elongation (GO:0022616)4.16407235
22protein maturation by protein folding (GO:0022417)4.14154709
23telomere maintenance via semi-conservative replication (GO:0032201)4.09177927
24proline biosynthetic process (GO:0006561)4.08147541
25ribonucleoprotein complex biogenesis (GO:0022613)4.02772823
26cellular protein complex disassembly (GO:0043624)4.00230361
27nucleobase-containing small molecule interconversion (GO:0015949)3.93920228
28GTP biosynthetic process (GO:0006183)3.91957348
29viral life cycle (GO:0019058)3.84252089
30regulation of mammary gland epithelial cell proliferation (GO:0033599)3.82560038
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.82268046
32regulation of translational fidelity (GO:0006450)3.80320028
33UTP biosynthetic process (GO:0006228)3.79392727
34establishment of integrated proviral latency (GO:0075713)3.78865082
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.78509961
36spliceosomal snRNP assembly (GO:0000387)3.76806493
37* transcription elongation from RNA polymerase III promoter (GO:0006385)3.75362121
38* termination of RNA polymerase III transcription (GO:0006386)3.75362121
39rRNA processing (GO:0006364)3.71442250
40ATP synthesis coupled proton transport (GO:0015986)3.66982187
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66982187
42guanosine-containing compound biosynthetic process (GO:1901070)3.64974871
43translation (GO:0006412)3.64192562
44cellular component biogenesis (GO:0044085)3.57600887
45peptidyl-arginine omega-N-methylation (GO:0035247)3.57128474
46rRNA metabolic process (GO:0016072)3.56376208
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.55097434
48central nervous system myelination (GO:0022010)3.52284031
49axon ensheathment in central nervous system (GO:0032291)3.52284031
50ribosome biogenesis (GO:0042254)3.52037936
51rRNA transcription (GO:0009303)3.51636837
52regulation of translational termination (GO:0006449)3.49252650
53rRNA modification (GO:0000154)3.48572861
54DNA unwinding involved in DNA replication (GO:0006268)3.46086109
55protein complex disassembly (GO:0043241)3.45318802
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.45077372
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.45077372
58NADH dehydrogenase complex assembly (GO:0010257)3.45077372
59DNA replication checkpoint (GO:0000076)3.44237726
60protein targeting to mitochondrion (GO:0006626)3.43768610
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38213406
62chaperone-mediated protein transport (GO:0072321)3.37460741
63establishment of protein localization to mitochondrion (GO:0072655)3.36372546
64pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.35906583
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33944242
66CTP metabolic process (GO:0046036)3.33076486
67CTP biosynthetic process (GO:0006241)3.33076486
68telomere maintenance via recombination (GO:0000722)3.31750426
69UTP metabolic process (GO:0046051)3.31155606
70macromolecular complex disassembly (GO:0032984)3.30939533
71cullin deneddylation (GO:0010388)3.29911295
72nucleobase biosynthetic process (GO:0046112)3.28505098
73telomere maintenance via telomere lengthening (GO:0010833)3.27994057
74pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.27857655
75pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.27787821
76formation of translation preinitiation complex (GO:0001731)3.24378153
77positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.24119771
78CENP-A containing nucleosome assembly (GO:0034080)3.22457352
79mitotic nuclear envelope reassembly (GO:0007084)3.17751982
80nuclear envelope reassembly (GO:0031468)3.17751982
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16126403
82negative regulation of ligase activity (GO:0051352)3.16126403
83chromatin remodeling at centromere (GO:0031055)3.15981941
84protein retention in ER lumen (GO:0006621)3.15056539
85negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13524642
86protein deneddylation (GO:0000338)3.11950392
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11565523
88UV protection (GO:0009650)3.11168369
89ncRNA 3-end processing (GO:0043628)3.10899876
90nucleotide-excision repair, DNA gap filling (GO:0006297)3.10730099
91rRNA methylation (GO:0031167)3.10519200
92transcription from mitochondrial promoter (GO:0006390)3.10232383
93protein localization to mitochondrion (GO:0070585)3.09467129
94histone arginine methylation (GO:0034969)3.08811384
95ribosome assembly (GO:0042255)3.08760036
96negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07895346
977-methylguanosine mRNA capping (GO:0006370)3.07894558
98protein complex biogenesis (GO:0070271)3.07789070
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07508508
1007-methylguanosine RNA capping (GO:0009452)3.07282014
101RNA capping (GO:0036260)3.07282014
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06878467
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06394846
104purine nucleobase biosynthetic process (GO:0009113)3.06207024
105transcription-coupled nucleotide-excision repair (GO:0006283)3.05101600
106nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04023753
107proline metabolic process (GO:0006560)3.03661308
108regulation of mitochondrial translation (GO:0070129)3.01089086
109adenine nucleotide transport (GO:0051503)3.01077496
110folic acid metabolic process (GO:0046655)3.00791911
111establishment of viral latency (GO:0019043)2.99589023
112mitochondrial respiratory chain complex assembly (GO:0033108)2.97024359
113pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.96243644
114mitotic chromosome condensation (GO:0007076)2.96129782
115spliceosomal complex assembly (GO:0000245)2.95235020
116pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.94835287
117transcription elongation from RNA polymerase I promoter (GO:0006362)2.94519771
118amino acid salvage (GO:0043102)2.93783198
119L-methionine salvage (GO:0071267)2.93783198
120L-methionine biosynthetic process (GO:0071265)2.93783198
121mitotic recombination (GO:0006312)2.93462105
122mitochondrial fusion (GO:0008053)2.92952936
123protein complex localization (GO:0031503)2.92494114
124synaptic vesicle docking involved in exocytosis (GO:0016081)2.90649233
125regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.90421516
126DNA replication-dependent nucleosome assembly (GO:0006335)2.90298459
127DNA replication-dependent nucleosome organization (GO:0034723)2.90298459
128ncRNA processing (GO:0034470)2.89654012
129maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89409082
130deoxyribose phosphate biosynthetic process (GO:0046385)2.86672212
1312-deoxyribonucleotide biosynthetic process (GO:0009265)2.86672212
132negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.86304792
133Golgi transport vesicle coating (GO:0048200)2.83980382
134COPI coating of Golgi vesicle (GO:0048205)2.83980382
135protein insertion into membrane (GO:0051205)2.82157794
136cellular protein complex localization (GO:0034629)2.82025603
137peptidyl-histidine modification (GO:0018202)2.75558167
138base-excision repair, AP site formation (GO:0006285)2.74853419
139negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.71810571
140spliceosomal tri-snRNP complex assembly (GO:0000244)2.66520454
141positive regulation of synapse maturation (GO:0090129)2.65915824
142peptidyl-arginine methylation (GO:0018216)2.63125276
143peptidyl-arginine N-methylation (GO:0035246)2.63125276
144negative regulation of cell size (GO:0045792)2.62925760
145positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.62341747
146regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.62341747
147tRNA methylation (GO:0030488)2.60174980
148heterochromatin organization (GO:0070828)2.51952661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.39464733
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.81338697
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.22650000
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.18219488
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02876682
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.81759046
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.78248127
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.67698284
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.60847160
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.50368376
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.41228459
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.39864886
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.21018340
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.10552976
15CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01332755
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98716608
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98083215
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96804811
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85626309
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76125592
21* XRN2_22483619_ChIP-Seq_HELA_Human2.68262493
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63308504
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.56825765
24VDR_21846776_ChIP-Seq_THP-1_Human2.49879012
25* VDR_23849224_ChIP-Seq_CD4+_Human2.41530226
26DCP1A_22483619_ChIP-Seq_HELA_Human2.39031079
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22127901
28LXR_22292898_ChIP-Seq_THP-1_Human2.19363963
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16656690
30FOXP3_21729870_ChIP-Seq_TREG_Human2.15934076
31TTF2_22483619_ChIP-Seq_HELA_Human2.13849690
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.08386089
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07141841
34* GABP_19822575_ChIP-Seq_HepG2_Human2.06903980
35* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05305556
36* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98407652
37MYC_22102868_ChIP-Seq_BL_Human1.98231900
38ZNF263_19887448_ChIP-Seq_K562_Human1.96365519
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.91839740
40* SRF_21415370_ChIP-Seq_HL-1_Mouse1.88829404
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85760451
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80479849
43* TET1_21451524_ChIP-Seq_MESCs_Mouse1.77427296
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74968600
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74255747
46P68_20966046_ChIP-Seq_HELA_Human1.73964509
47RACK7_27058665_Chip-Seq_MCF-7_Human1.73294935
48* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71766632
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65550855
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.64068653
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62528352
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61788595
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57030322
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55724379
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.53648060
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52652358
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51083298
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50991058
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50580359
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.47163943
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46714193
62AR_21909140_ChIP-Seq_LNCAP_Human1.44600910
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44375491
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42593736
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38465718
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37301055
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36712791
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.36619888
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35891798
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.34654627
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34231560
72ELK1_19687146_ChIP-ChIP_HELA_Human1.33417627
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.31096201
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.29519196
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27565985
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27471715
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27331897
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27251824
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27106517
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26413980
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26288073
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.26253812
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25708520
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25516326
85MYC_18940864_ChIP-ChIP_HL60_Human1.23272944
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21876978
87CIITA_25753668_ChIP-Seq_RAJI_Human1.21874976
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21707652
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21703619
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21667794
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21662736
92* SMC4_20622854_ChIP-Seq_HELA_Human1.19707023
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19230524
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15084624
95KDM5A_27292631_Chip-Seq_BREAST_Human1.13577646
96KDM2B_26808549_Chip-Seq_DND41_Human1.12530635
97MAF_26560356_Chip-Seq_TH2_Human1.11812569
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11683343
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10915402
100IRF1_19129219_ChIP-ChIP_H3396_Human1.10586292
101CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10548695
102TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10349242
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09099122
104RARA_24833708_ChIP-Seq_LIVER_Mouse1.08906816
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08582927
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08523646
107BCOR_27268052_Chip-Seq_Bcells_Human1.08273828
108ATF3_27146783_Chip-Seq_COLON_Human1.08020529
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07711067
110SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07668228
111CREB1_26743006_Chip-Seq_LNCaP_Human1.07434922
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.06355277
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04954239
114KDM2B_26808549_Chip-Seq_K562_Human1.04626664
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04558807
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04501295
117RARB_24833708_ChIP-Seq_LIVER_Mouse1.04000951
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03860118
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03849442
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03369747
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03150806
122EZH2_22144423_ChIP-Seq_EOC_Human1.02729762
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02443733
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00924949
125CTCF_27219007_Chip-Seq_Bcells_Human0.99526558
126* YY1_22570637_ChIP-Seq_MALME-3M_Human0.99306689
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97730305
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97268342
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94249819
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92563418
131* FOXP1_21924763_ChIP-Seq_HESCs_Human0.91197726
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90070423
133* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87339541
134SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83630012
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83524069
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81704969
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81367094
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77422467
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75408790
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.73939876
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73745049
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72788357
143TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71901630
144TFEB_21752829_ChIP-Seq_HELA_Human0.69766101
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69340941
146CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.68913995
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66196777
148SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.65641265
149TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.64563067
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.64352615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.31737724
2MP0009379_abnormal_foot_pigmentation4.04117464
3MP0003693_abnormal_embryo_hatching3.40233167
4MP0004957_abnormal_blastocyst_morpholog3.23181868
5MP0003880_abnormal_central_pattern3.11180076
6MP0010094_abnormal_chromosome_stability2.85288534
7MP0003136_yellow_coat_color2.73904309
8MP0003111_abnormal_nucleus_morphology2.70538400
9MP0008057_abnormal_DNA_replication2.67371237
10MP0005623_abnormal_meninges_morphology2.64918312
11MP0008932_abnormal_embryonic_tissue2.50775512
12MP0004858_abnormal_nervous_system2.45121810
13MP0005171_absent_coat_pigmentation2.40792999
14MP0008058_abnormal_DNA_repair2.31145280
15MP0004185_abnormal_adipocyte_glucose2.20058301
16MP0003077_abnormal_cell_cycle2.18481735
17MP0001529_abnormal_vocalization2.12647686
18MP0010030_abnormal_orbit_morphology2.10015444
19MP0006292_abnormal_olfactory_placode2.09765336
20MP0004233_abnormal_muscle_weight2.00958342
21MP0008438_abnormal_cutaneous_collagen1.95967834
22MP0000751_myopathy1.93263542
23MP0005423_abnormal_somatic_nervous1.89419081
24MP0001485_abnormal_pinna_reflex1.85847618
25MP0002877_abnormal_melanocyte_morpholog1.85675928
26MP0002249_abnormal_larynx_morphology1.81681631
27MP0004142_abnormal_muscle_tone1.81295912
28MP0005058_abnormal_lysosome_morphology1.79156590
29MP0001905_abnormal_dopamine_level1.78504293
30MP0005076_abnormal_cell_differentiation1.77140853
31MP0003329_amyloid_beta_deposits1.74995067
32MP0008007_abnormal_cellular_replicative1.74287159
33MP0005501_abnormal_skin_physiology1.73545823
34MP0001188_hyperpigmentation1.68052616
35MP0004859_abnormal_synaptic_plasticity1.67171683
36MP0003718_maternal_effect1.66789925
37MP0005257_abnormal_intraocular_pressure1.63773539
38MP0003635_abnormal_synaptic_transmissio1.61607462
39MP0002272_abnormal_nervous_system1.60385747
40MP0002102_abnormal_ear_morphology1.59264476
41MP0001486_abnormal_startle_reflex1.57161967
42MP0003786_premature_aging1.56906876
43MP0002064_seizures1.52124869
44MP0001968_abnormal_touch/_nociception1.50965393
45MP0003806_abnormal_nucleotide_metabolis1.50541273
46MP0000003_abnormal_adipose_tissue1.47926766
47MP0005379_endocrine/exocrine_gland_phen1.46056534
48MP0008877_abnormal_DNA_methylation1.44589830
49MP0003938_abnormal_ear_development1.41903699
50MP0004885_abnormal_endolymph1.41356974
51MP0005451_abnormal_body_composition1.40759179
52MP0002736_abnormal_nociception_after1.40712114
53MP0009745_abnormal_behavioral_response1.38122272
54MP0002796_impaired_skin_barrier1.37933761
55MP0002638_abnormal_pupillary_reflex1.37677357
56MP0001661_extended_life_span1.36234454
57MP0004270_analgesia1.36086502
58MP0000747_muscle_weakness1.35416145
59MP0009046_muscle_twitch1.34066732
60MP0000759_abnormal_skeletal_muscle1.31749915
61MP0006276_abnormal_autonomic_nervous1.30741792
62MP0000678_abnormal_parathyroid_gland1.26726980
63MP0003453_abnormal_keratinocyte_physiol1.26123449
64MP0001849_ear_inflammation1.26061543
65MP0003315_abnormal_perineum_morphology1.23336519
66MP0002060_abnormal_skin_morphology1.22921048
67MP0000750_abnormal_muscle_regeneration1.22796902
68MP0006036_abnormal_mitochondrial_physio1.22237310
69MP0009780_abnormal_chondrocyte_physiolo1.22098131
70MP0001348_abnormal_lacrimal_gland1.21861990
71MP0001958_emphysema1.21719033
72MP0001346_abnormal_lacrimal_gland1.20926364
73MP0001984_abnormal_olfaction1.20085169
74MP0000733_abnormal_muscle_development1.19184909
75MP0002396_abnormal_hematopoietic_system1.18980274
76MP0003566_abnormal_cell_adhesion1.17085640
77MP0004147_increased_porphyrin_level1.16503988
78MP0002572_abnormal_emotion/affect_behav1.16268767
79MP0002734_abnormal_mechanical_nocicepti1.15950986
80MP0002733_abnormal_thermal_nociception1.15272322
81MP0001502_abnormal_circadian_rhythm1.14608034
82MP0002210_abnormal_sex_determination1.13988034
83MP0009333_abnormal_splenocyte_physiolog1.13784472
84MP0006035_abnormal_mitochondrial_morpho1.12715382
85MP0009053_abnormal_anal_canal1.12246441
86MP0001730_embryonic_growth_arrest1.11719780
87MP0001986_abnormal_taste_sensitivity1.11670718
88MP0003942_abnormal_urinary_system1.10118141
89MP0003656_abnormal_erythrocyte_physiolo1.09947905
90MP0001672_abnormal_embryogenesis/_devel1.08985165
91MP0005380_embryogenesis_phenotype1.08985165
92MP0000631_abnormal_neuroendocrine_gland1.08894824
93MP0005409_darkened_coat_color1.08100748
94MP0002067_abnormal_sensory_capabilities1.07493792
95MP0000566_synostosis1.07455144
96MP0000013_abnormal_adipose_tissue1.07357451
97MP0002653_abnormal_ependyma_morphology1.06224625
98MP0002163_abnormal_gland_morphology1.05968631
99MP0009672_abnormal_birth_weight1.05558760
100MP0001145_abnormal_male_reproductive1.05379378
101MP0000778_abnormal_nervous_system1.05229299
102MP0001440_abnormal_grooming_behavior1.04761730
103MP0006072_abnormal_retinal_apoptosis1.04122693
104MP0002938_white_spotting1.04073894
105MP0004133_heterotaxia1.03564059
106MP0000358_abnormal_cell_content/1.02875884
107MP0000049_abnormal_middle_ear1.02183393
108MP0009840_abnormal_foam_cell1.01817804
109MP0004742_abnormal_vestibular_system0.99866915
110MP0001970_abnormal_pain_threshold0.99757370
111MP0001542_abnormal_bone_strength0.98069085
112MP0000313_abnormal_cell_death0.97995892
113MP0000350_abnormal_cell_proliferation0.97959182
114MP0002063_abnormal_learning/memory/cond0.97694328
115MP0001929_abnormal_gametogenesis0.97568013
116MP0003698_abnormal_male_reproductive0.97379244
117MP0000920_abnormal_myelination0.95737016
118MP0000955_abnormal_spinal_cord0.94888968
119MP0003634_abnormal_glial_cell0.94831553
120MP0002882_abnormal_neuron_morphology0.94496647
121MP0005646_abnormal_pituitary_gland0.93545413
122MP0005621_abnormal_cell_physiology0.93455637
123MP0002152_abnormal_brain_morphology0.92448370
124MP0003984_embryonic_growth_retardation0.92319021
125MP0005410_abnormal_fertilization0.91534080
126MP0002751_abnormal_autonomic_nervous0.91293094
127MP0002557_abnormal_social/conspecific_i0.90831017
128MP0003123_paternal_imprinting0.89781521
129MP0003137_abnormal_impulse_conducting0.89543712
130MP0000534_abnormal_ureter_morphology0.89132438
131MP0000462_abnormal_digestive_system0.89086918
132MP0005174_abnormal_tail_pigmentation0.88643051
133MP0005503_abnormal_tendon_morphology0.88202990
134MP0005330_cardiomyopathy0.87695439
135MP0002752_abnormal_somatic_nervous0.87636478
136MP0002095_abnormal_skin_pigmentation0.87384677
137MP0005375_adipose_tissue_phenotype0.86614501
138MP0000653_abnormal_sex_gland0.85971727
139MP0002089_abnormal_postnatal_growth/wei0.85967170
140MP0003861_abnormal_nervous_system0.85772114
141MP0000762_abnormal_tongue_morphology0.85514445
142MP0002066_abnormal_motor_capabilities/c0.85100478
143MP0002080_prenatal_lethality0.84735682
144MP0000749_muscle_degeneration0.83239047
145MP0000026_abnormal_inner_ear0.83209053
146MP0010307_abnormal_tumor_latency0.83130400
147MP0003279_aneurysm0.83025692
148MP0010771_integument_phenotype0.82731855
149MP0005384_cellular_phenotype0.82460546
150MP0001963_abnormal_hearing_physiology0.82173593
151MP0002088_abnormal_embryonic_growth/wei0.82173436
152MP0000537_abnormal_urethra_morphology0.82103716
153MP0002229_neurodegeneration0.80977250
154MP0000681_abnormal_thyroid_gland0.80365786
155MP0002160_abnormal_reproductive_system0.80353744
156MP0008260_abnormal_autophagy0.78254581
157MP0002114_abnormal_axial_skeleton0.77959670
158MP0008569_lethality_at_weaning0.77861994
159MP0003011_delayed_dark_adaptation0.77746573
160MP0001697_abnormal_embryo_size0.75460043
161MP0001881_abnormal_mammary_gland0.75180281
162MP0002085_abnormal_embryonic_tissue0.75044338
163MP0005508_abnormal_skeleton_morphology0.72207584
164MP0009250_abnormal_appendicular_skeleto0.71468847
165MP0003879_abnormal_hair_cell0.70981593
166MP0002084_abnormal_developmental_patter0.70436519
167MP0005083_abnormal_biliary_tract0.69723244
168MP0000538_abnormal_urinary_bladder0.69361255
169MP0003186_abnormal_redox_activity0.69242903
170MP0004087_abnormal_muscle_fiber0.68696240

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)4.85762092
2Cerebral hypomyelination (HP:0006808)4.59328597
3Abnormality of cells of the erythroid lineage (HP:0012130)4.37260163
4Abnormal number of erythroid precursors (HP:0012131)4.23804738
5Hyperacusis (HP:0010780)3.82044504
6Mitochondrial inheritance (HP:0001427)3.79912740
7Ulnar bowing (HP:0003031)3.72014096
8Increased hepatocellular lipid droplets (HP:0006565)3.69494699
9Hepatocellular necrosis (HP:0001404)3.64384550
10Acute necrotizing encephalopathy (HP:0006965)3.63735822
11Reticulocytopenia (HP:0001896)3.51212263
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.49137910
13Birth length less than 3rd percentile (HP:0003561)3.48956751
14Macrocytic anemia (HP:0001972)3.45734294
15Increased CSF lactate (HP:0002490)3.39831576
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.27230527
17Abnormal mitochondria in muscle tissue (HP:0008316)3.26289853
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22814524
19CNS hypomyelination (HP:0003429)3.18379125
20Insomnia (HP:0100785)3.14390485
21Breast hypoplasia (HP:0003187)3.13378868
22Lipid accumulation in hepatocytes (HP:0006561)3.10862575
23Increased serum lactate (HP:0002151)3.06062164
24Achilles tendon contracture (HP:0001771)3.02492481
25Split foot (HP:0001839)2.95838712
26Ragged-red muscle fibers (HP:0003200)2.92748406
27Acute encephalopathy (HP:0006846)2.91524431
283-Methylglutaconic aciduria (HP:0003535)2.90793602
29Renal Fanconi syndrome (HP:0001994)2.89747176
30Progressive macrocephaly (HP:0004481)2.87464715
31Premature rupture of membranes (HP:0001788)2.83913516
32Pallor (HP:0000980)2.80653470
33Increased intramyocellular lipid droplets (HP:0012240)2.75999279
34Rough bone trabeculation (HP:0100670)2.71411172
35Hepatic necrosis (HP:0002605)2.68333650
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67547996
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67547996
38Oral leukoplakia (HP:0002745)2.66469607
39Overriding aorta (HP:0002623)2.63424048
40Delusions (HP:0000746)2.61041456
41Hypoplastic pelvis (HP:0008839)2.55325600
42Megalencephaly (HP:0001355)2.55152383
43Increased serum pyruvate (HP:0003542)2.54958696
44Abnormality of glycolysis (HP:0004366)2.54958696
45Trismus (HP:0000211)2.54088986
46Annular pancreas (HP:0001734)2.53802935
47Protrusio acetabuli (HP:0003179)2.53151438
48Exertional dyspnea (HP:0002875)2.52411023
49Abnormality of the Achilles tendon (HP:0005109)2.51316589
50Obstructive sleep apnea (HP:0002870)2.51214148
51Broad distal phalanx of finger (HP:0009836)2.51022963
52Emotional lability (HP:0000712)2.49771314
53Thin bony cortex (HP:0002753)2.44446215
54Myokymia (HP:0002411)2.44355124
55Aplasia/hypoplasia of the uterus (HP:0008684)2.42318583
56Secondary amenorrhea (HP:0000869)2.42169987
57Exercise intolerance (HP:0003546)2.40275900
58Postnatal microcephaly (HP:0005484)2.39797217
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.37217500
60Vertebral compression fractures (HP:0002953)2.36731588
61Respiratory difficulties (HP:0002880)2.34899920
62Retinal dysplasia (HP:0007973)2.34666149
63CNS demyelination (HP:0007305)2.34242833
64Lactic acidosis (HP:0003128)2.33326175
65Microvesicular hepatic steatosis (HP:0001414)2.28693757
66Respiratory failure (HP:0002878)2.28241186
67Generalized amyotrophy (HP:0003700)2.27360925
68Abnormality of the phalanges of the hallux (HP:0010057)2.27046396
69Squamous cell carcinoma (HP:0002860)2.23510764
70Selective tooth agenesis (HP:0001592)2.23284963
71Truncus arteriosus (HP:0001660)2.23218933
72Turricephaly (HP:0000262)2.23033238
73Abnormality of the umbilical cord (HP:0010881)2.21637627
74Unsteady gait (HP:0002317)2.21400405
75Abnormality of the distal phalanges of the toes (HP:0010182)2.18939267
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18388188
77Abnormality of alanine metabolism (HP:0010916)2.18388188
78Hyperalaninemia (HP:0003348)2.18388188
79Abnormal respiratory epithelium morphology (HP:0012253)2.18357900
80Abnormal respiratory motile cilium morphology (HP:0005938)2.18357900
81Progressive muscle weakness (HP:0003323)2.17183354
82Myopathic facies (HP:0002058)2.16406737
83Microretrognathia (HP:0000308)2.15595712
84Premature graying of hair (HP:0002216)2.15215896
85Patellar dislocation (HP:0002999)2.14018951
86Spinal cord compression (HP:0002176)2.12204498
87Abnormality of secondary sexual hair (HP:0009888)2.11679468
88Abnormality of the axillary hair (HP:0100134)2.11679468
89Morphological abnormality of the inner ear (HP:0011390)2.11209502
90Type I transferrin isoform profile (HP:0003642)2.10251708
91Athetosis (HP:0002305)2.10075501
92Leukodystrophy (HP:0002415)2.09721967
93Hyperparathyroidism (HP:0000843)2.09573585
94Increased muscle lipid content (HP:0009058)2.09061792
95Severe visual impairment (HP:0001141)2.07675804
96Ankle contracture (HP:0006466)2.06791255
97Elfin facies (HP:0004428)2.06524035
98Concave nail (HP:0001598)2.06046709
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05866232
100Short nail (HP:0001799)2.04952753
101Upper limb amyotrophy (HP:0009129)2.04854478
102Distal upper limb amyotrophy (HP:0007149)2.04854478
103Premature skin wrinkling (HP:0100678)2.03203240
104Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01112358
105Bowed forearm bones (HP:0003956)2.00053010
106Bowing of the arm (HP:0006488)2.00053010
107Peripheral hypomyelination (HP:0007182)1.99730991
108Aplastic anemia (HP:0001915)1.99568978
109Optic disc pallor (HP:0000543)1.97984438
110Bladder diverticulum (HP:0000015)1.95979293
111Renal duplication (HP:0000075)1.95930860
112Intestinal fistula (HP:0100819)1.94222967
113Asplenia (HP:0001746)1.93738971
114Genu recurvatum (HP:0002816)1.93364469
115Aplasia involving forearm bones (HP:0009822)1.93065605
116Absent forearm bone (HP:0003953)1.93065605
117Abnormalities of placenta or umbilical cord (HP:0001194)1.91795770
118Hyperthyroidism (HP:0000836)1.90998169
119Vaginal fistula (HP:0004320)1.90851209
120Long palpebral fissure (HP:0000637)1.90601427
121Elbow flexion contracture (HP:0002987)1.89030635
122Pancytopenia (HP:0001876)1.88951967
123Progressive external ophthalmoplegia (HP:0000590)1.88073760
124Spastic paraparesis (HP:0002313)1.87981001
125Congenital hip dislocation (HP:0001374)1.87041621
126Increased connective tissue (HP:0009025)1.85815822
127Aplasia of the musculature (HP:0100854)1.85180582
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84741888
129Premature ovarian failure (HP:0008209)1.84430271
130Hypercalcemia (HP:0003072)1.83953091
131Mitral regurgitation (HP:0001653)1.82917963
132Self-mutilation (HP:0000742)1.82912001
133Triphalangeal thumb (HP:0001199)1.82108563
134Supernumerary spleens (HP:0009799)1.80591030
135Abnormal umbilical cord blood vessels (HP:0011403)1.80292142
136Single umbilical artery (HP:0001195)1.80292142
137Abnormality of the fetal cardiovascular system (HP:0010948)1.80292142
138Spinal rigidity (HP:0003306)1.79242048
139Hypoplasia of the radius (HP:0002984)1.78488564
140Sensory axonal neuropathy (HP:0003390)1.77779249
141Fragile skin (HP:0001030)1.77536717
142Sparse lateral eyebrow (HP:0005338)1.77469431
143Patellar aplasia (HP:0006443)1.76000661
144Rectovaginal fistula (HP:0000143)1.75999381
145Rectal fistula (HP:0100590)1.75999381
146Abnormal respiratory motile cilium physiology (HP:0012261)1.75704503
147Abnormal trabecular bone morphology (HP:0100671)1.74672929
148Abnormality of the intrinsic pathway (HP:0010989)1.74527804
149Pointed chin (HP:0000307)1.74456424
150Horseshoe kidney (HP:0000085)1.74436451
151Akinesia (HP:0002304)1.74217017
152Shallow orbits (HP:0000586)1.73602420
153Coronal craniosynostosis (HP:0004440)1.72051277
154Abnormality of placental membranes (HP:0011409)1.71932472
155Amniotic constriction ring (HP:0009775)1.71932472
156Megaloblastic anemia (HP:0001889)1.71647257
157Urethral obstruction (HP:0000796)1.71318090
158Stridor (HP:0010307)1.71143373
159Aplasia/Hypoplasia of the spleen (HP:0010451)1.71113285
160Abnormality of renal resorption (HP:0011038)1.70095580
161Rib fusion (HP:0000902)1.69220413
162Slender long bone (HP:0003100)1.69166348
163Abnormal protein glycosylation (HP:0012346)1.69159517
164Abnormal glycosylation (HP:0012345)1.69159517
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69159517
166Abnormal protein N-linked glycosylation (HP:0012347)1.69159517
167Abnormality of the preputium (HP:0100587)1.69028837
168Type II lissencephaly (HP:0007260)1.67743880
169Abnormal ciliary motility (HP:0012262)1.67408455
170Cerebellar dysplasia (HP:0007033)1.64302680
171Glossoptosis (HP:0000162)1.64061423
172Aplasia/Hypoplasia of the patella (HP:0006498)1.63547757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.66475029
2TRIB34.52043938
3STK163.98433876
4WEE13.73380415
5EIF2AK13.54445034
6TLK13.42077381
7NME22.88459650
8SMG12.78766323
9TESK22.65895534
10TNIK2.64132513
11ICK2.54285926
12EEF2K2.43286681
13IRAK32.38669061
14CDK192.36411713
15CDC72.34480945
16TESK12.32673202
17VRK12.11645592
18NME12.07772606
19PNCK2.06332887
20SIK11.97898229
21PRPF4B1.83679102
22PRKD31.77311349
23SRPK11.76554504
24CASK1.70397304
25EPHA41.69760857
26CDK121.66428851
27DYRK31.62815265
28MKNK21.60642393
29MKNK11.49518125
30FES1.40437909
31PAK41.37854471
32TSSK61.37719518
33EIF2AK31.35331978
34VRK21.30337139
35AURKA1.29140079
36TAOK21.28278261
37ACVR1B1.26629882
38LATS21.26341897
39SCYL21.23990829
40RIPK11.18751372
41MAPK151.18200985
42PLK11.18029289
43STK391.14921298
44PBK1.14290350
45TTK1.11901584
46DYRK21.10264676
47MAPKAPK51.10090839
48CDK71.09013232
49ERN11.07361697
50TTN1.06668095
51CDK81.06299332
52PIM21.04676825
53EPHA21.03661627
54NEK21.01169860
55CCNB11.00567121
56MAP2K70.98328763
57MAPK110.97389428
58MTOR0.95135931
59CSNK1G30.94893000
60CDK140.93657345
61OXSR10.89418261
62MST40.88406200
63CHEK20.88315820
64PRKD20.88258852
65CDK11A0.87582495
66BRSK20.87004846
67MUSK0.85877457
68CDK150.85253611
69BRSK10.85207129
70PDK20.84452417
71BRAF0.84196206
72CAMK1D0.83437951
73AURKB0.82726449
74LRRK20.82156684
75MAP3K100.81975611
76PAK20.81623810
77MINK10.81366868
78MAPK130.81020301
79CDK180.80904163
80PAK10.79868513
81ARAF0.78631945
82UHMK10.77608064
83RPS6KA20.77586190
84MAP3K110.77235384
85PTK20.76944815
86MARK20.76750506
87AKT20.73224840
88CSNK2A20.72700257
89CDK40.72051314
90LIMK10.71950329
91MAP2K30.70371236
92CAMKK10.68938305
93MAPKAPK30.66596898
94CSNK1G10.66171491
95PKN20.65614465
96MAP3K80.64316376
97CAMK2B0.63795958
98MARK10.63790754
99MAP2K20.63647181
100RAF10.63226752
101CAMK2G0.63134960
102PDPK10.61987255
103ATR0.61299654
104KDR0.61127280
105MAP3K40.58198149
106PLK40.58095731
107NTRK20.55830918
108RPS6KC10.55713596
109RPS6KL10.55713596
110IRAK20.54481071
111PHKG20.54098463
112PHKG10.54098463
113LMTK20.53985519
114CLK10.52823444
115CSNK2A10.52560633
116IRAK10.52383166
117ABL20.51359981
118PLK30.50770827
119CSNK1G20.49299732
120CDC42BPA0.49100863
121ALK0.48459350
122BLK0.47925124
123CHEK10.46653348
124PRKCI0.46631836
125PDGFRA0.46510197
126DMPK0.46113802
127ROCK20.44933529
128MST1R0.44448179
129SIK20.44092856
130MAP3K60.43563092
131MAP3K90.43157166
132PRKCG0.42907460
133DAPK10.42574612
134ADRBK10.42012933
135CSNK1A1L0.40474168
136CAMK1G0.40295739
137BCKDK0.39820980
138NTRK10.39694340
139PASK0.38336737
140CDK20.38064318
141GRK60.38023467
142CSNK1E0.37843527
143BMPR1B0.37435148
144PAK60.37154871
145CDK50.36944896
146RPS6KB20.36416605
147RPS6KA60.36132312
148MAP3K10.36090217
149MAPK120.36072618
150RPS6KA50.36070016
151ILK0.34927493
152DAPK30.34690237

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.92763966
2DNA replication_Homo sapiens_hsa030304.50746140
3Mismatch repair_Homo sapiens_hsa034303.64318235
4* RNA polymerase_Homo sapiens_hsa030203.64204534
5Proteasome_Homo sapiens_hsa030503.63561722
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17130862
7Spliceosome_Homo sapiens_hsa030402.85146716
8Oxidative phosphorylation_Homo sapiens_hsa001902.75713621
9Homologous recombination_Homo sapiens_hsa034402.71693983
10Nucleotide excision repair_Homo sapiens_hsa034202.62808573
11Parkinsons disease_Homo sapiens_hsa050122.57328571
12* Pyrimidine metabolism_Homo sapiens_hsa002402.54874875
13Base excision repair_Homo sapiens_hsa034102.42012075
14RNA transport_Homo sapiens_hsa030132.41083866
15Protein export_Homo sapiens_hsa030602.38933062
16Huntingtons disease_Homo sapiens_hsa050162.05556083
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88978426
18Basal transcription factors_Homo sapiens_hsa030221.77982070
19Fanconi anemia pathway_Homo sapiens_hsa034601.75109874
20Cell cycle_Homo sapiens_hsa041101.74941477
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73917615
22Alzheimers disease_Homo sapiens_hsa050101.69385292
23One carbon pool by folate_Homo sapiens_hsa006701.60425587
24* Purine metabolism_Homo sapiens_hsa002301.60040715
25Non-homologous end-joining_Homo sapiens_hsa034501.56437568
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53735883
27Sulfur relay system_Homo sapiens_hsa041221.49476032
28Vitamin B6 metabolism_Homo sapiens_hsa007501.49116449
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44403508
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37452665
31RNA degradation_Homo sapiens_hsa030181.21625870
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21224117
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19788627
34Cardiac muscle contraction_Homo sapiens_hsa042601.18769155
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13821735
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06707821
37Oocyte meiosis_Homo sapiens_hsa041141.03014666
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01157036
39Folate biosynthesis_Homo sapiens_hsa007900.99713804
40Nicotine addiction_Homo sapiens_hsa050330.98006864
41Central carbon metabolism in cancer_Homo sapiens_hsa052300.97908346
42mRNA surveillance pathway_Homo sapiens_hsa030150.96341081
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93992105
44Prion diseases_Homo sapiens_hsa050200.92547686
45Alcoholism_Homo sapiens_hsa050340.90046278
46Systemic lupus erythematosus_Homo sapiens_hsa053220.86450087
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.82904291
48Pentose phosphate pathway_Homo sapiens_hsa000300.80409835
49Notch signaling pathway_Homo sapiens_hsa043300.79111564
50Phenylalanine metabolism_Homo sapiens_hsa003600.77303605
51p53 signaling pathway_Homo sapiens_hsa041150.76632144
52Non-small cell lung cancer_Homo sapiens_hsa052230.72197727
53VEGF signaling pathway_Homo sapiens_hsa043700.69603811
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.68668926
55Biosynthesis of amino acids_Homo sapiens_hsa012300.66961835
56mTOR signaling pathway_Homo sapiens_hsa041500.66608145
57Glioma_Homo sapiens_hsa052140.65852199
58Chronic myeloid leukemia_Homo sapiens_hsa052200.65300181
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62968860
60N-Glycan biosynthesis_Homo sapiens_hsa005100.62393610
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61607753
62Lysine degradation_Homo sapiens_hsa003100.60714642
63Fatty acid elongation_Homo sapiens_hsa000620.59536397
64* Metabolic pathways_Homo sapiens_hsa011000.59356629
65* Epstein-Barr virus infection_Homo sapiens_hsa051690.58797131
66Hippo signaling pathway_Homo sapiens_hsa043900.57003824
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56083608
68AMPK signaling pathway_Homo sapiens_hsa041520.55123756
69* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54591938
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52875741
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52768320
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52338651
73Arginine and proline metabolism_Homo sapiens_hsa003300.51877755
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.51500994
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51133832
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49617933
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49058568
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.48353988
79Glutamatergic synapse_Homo sapiens_hsa047240.47949332
80GABAergic synapse_Homo sapiens_hsa047270.47367569
81Endocytosis_Homo sapiens_hsa041440.47264797
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46920535
83Ether lipid metabolism_Homo sapiens_hsa005650.45598253
84Glutathione metabolism_Homo sapiens_hsa004800.45131797
85Pancreatic cancer_Homo sapiens_hsa052120.43521920
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43098459
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41636558
88Endometrial cancer_Homo sapiens_hsa052130.41413914
89Galactose metabolism_Homo sapiens_hsa000520.40960611
90Renal cell carcinoma_Homo sapiens_hsa052110.40893779
91Sphingolipid metabolism_Homo sapiens_hsa006000.40763324
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40031001
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39493253
94Thyroid cancer_Homo sapiens_hsa052160.39339629
95HTLV-I infection_Homo sapiens_hsa051660.38996243
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38932143
97Apoptosis_Homo sapiens_hsa042100.38002705
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37711241
99Acute myeloid leukemia_Homo sapiens_hsa052210.37647112
100Insulin signaling pathway_Homo sapiens_hsa049100.37453447
101Melanogenesis_Homo sapiens_hsa049160.37035272
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36208757
103Steroid biosynthesis_Homo sapiens_hsa001000.34135163
104Long-term depression_Homo sapiens_hsa047300.33712537
105Colorectal cancer_Homo sapiens_hsa052100.32274078
106Arginine biosynthesis_Homo sapiens_hsa002200.31160071
107Morphine addiction_Homo sapiens_hsa050320.31019138
108Carbon metabolism_Homo sapiens_hsa012000.30723592
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30439639
110Amphetamine addiction_Homo sapiens_hsa050310.30024330
111Other glycan degradation_Homo sapiens_hsa005110.29826304
112Small cell lung cancer_Homo sapiens_hsa052220.29001267
113Serotonergic synapse_Homo sapiens_hsa047260.28692243
114Vibrio cholerae infection_Homo sapiens_hsa051100.27973715
115Long-term potentiation_Homo sapiens_hsa047200.26000083
116Gap junction_Homo sapiens_hsa045400.25852493
117Fatty acid biosynthesis_Homo sapiens_hsa000610.25174882
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23580583
119Phototransduction_Homo sapiens_hsa047440.21982425
120Pyruvate metabolism_Homo sapiens_hsa006200.20861095
121Viral carcinogenesis_Homo sapiens_hsa052030.20678808
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20627048
123Dopaminergic synapse_Homo sapiens_hsa047280.20050983
124Hedgehog signaling pathway_Homo sapiens_hsa043400.19110965
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.18983814
126Wnt signaling pathway_Homo sapiens_hsa043100.18936776
127Cocaine addiction_Homo sapiens_hsa050300.17063151
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16649334
129Regulation of autophagy_Homo sapiens_hsa041400.15077665
130Olfactory transduction_Homo sapiens_hsa047400.13990529
131Bladder cancer_Homo sapiens_hsa052190.13932438
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12331639
133Fructose and mannose metabolism_Homo sapiens_hsa000510.12331005
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.11865925
135Taste transduction_Homo sapiens_hsa047420.11575160
136Synaptic vesicle cycle_Homo sapiens_hsa047210.11498046
137Salivary secretion_Homo sapiens_hsa049700.11369262
138Arachidonic acid metabolism_Homo sapiens_hsa005900.11123289
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10862793
140Shigellosis_Homo sapiens_hsa051310.10190809
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10093987
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.07428003

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