| 1 | Testicular atrophy (HP:0000029) | 4.85762092 |
| 2 | Cerebral hypomyelination (HP:0006808) | 4.59328597 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.37260163 |
| 4 | Abnormal number of erythroid precursors (HP:0012131) | 4.23804738 |
| 5 | Hyperacusis (HP:0010780) | 3.82044504 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.79912740 |
| 7 | Ulnar bowing (HP:0003031) | 3.72014096 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.69494699 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.64384550 |
| 10 | Acute necrotizing encephalopathy (HP:0006965) | 3.63735822 |
| 11 | Reticulocytopenia (HP:0001896) | 3.51212263 |
| 12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.49137910 |
| 13 | Birth length less than 3rd percentile (HP:0003561) | 3.48956751 |
| 14 | Macrocytic anemia (HP:0001972) | 3.45734294 |
| 15 | Increased CSF lactate (HP:0002490) | 3.39831576 |
| 16 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.27230527 |
| 17 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.26289853 |
| 18 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.22814524 |
| 19 | CNS hypomyelination (HP:0003429) | 3.18379125 |
| 20 | Insomnia (HP:0100785) | 3.14390485 |
| 21 | Breast hypoplasia (HP:0003187) | 3.13378868 |
| 22 | Lipid accumulation in hepatocytes (HP:0006561) | 3.10862575 |
| 23 | Increased serum lactate (HP:0002151) | 3.06062164 |
| 24 | Achilles tendon contracture (HP:0001771) | 3.02492481 |
| 25 | Split foot (HP:0001839) | 2.95838712 |
| 26 | Ragged-red muscle fibers (HP:0003200) | 2.92748406 |
| 27 | Acute encephalopathy (HP:0006846) | 2.91524431 |
| 28 | 3-Methylglutaconic aciduria (HP:0003535) | 2.90793602 |
| 29 | Renal Fanconi syndrome (HP:0001994) | 2.89747176 |
| 30 | Progressive macrocephaly (HP:0004481) | 2.87464715 |
| 31 | Premature rupture of membranes (HP:0001788) | 2.83913516 |
| 32 | Pallor (HP:0000980) | 2.80653470 |
| 33 | Increased intramyocellular lipid droplets (HP:0012240) | 2.75999279 |
| 34 | Rough bone trabeculation (HP:0100670) | 2.71411172 |
| 35 | Hepatic necrosis (HP:0002605) | 2.68333650 |
| 36 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.67547996 |
| 37 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.67547996 |
| 38 | Oral leukoplakia (HP:0002745) | 2.66469607 |
| 39 | Overriding aorta (HP:0002623) | 2.63424048 |
| 40 | Delusions (HP:0000746) | 2.61041456 |
| 41 | Hypoplastic pelvis (HP:0008839) | 2.55325600 |
| 42 | Megalencephaly (HP:0001355) | 2.55152383 |
| 43 | Abnormality of glycolysis (HP:0004366) | 2.54958696 |
| 44 | Increased serum pyruvate (HP:0003542) | 2.54958696 |
| 45 | Trismus (HP:0000211) | 2.54088986 |
| 46 | Annular pancreas (HP:0001734) | 2.53802935 |
| 47 | Protrusio acetabuli (HP:0003179) | 2.53151438 |
| 48 | Exertional dyspnea (HP:0002875) | 2.52411023 |
| 49 | Abnormality of the Achilles tendon (HP:0005109) | 2.51316589 |
| 50 | Obstructive sleep apnea (HP:0002870) | 2.51214148 |
| 51 | Broad distal phalanx of finger (HP:0009836) | 2.51022963 |
| 52 | Emotional lability (HP:0000712) | 2.49771314 |
| 53 | Thin bony cortex (HP:0002753) | 2.44446215 |
| 54 | Myokymia (HP:0002411) | 2.44355124 |
| 55 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.42318583 |
| 56 | Secondary amenorrhea (HP:0000869) | 2.42169987 |
| 57 | Exercise intolerance (HP:0003546) | 2.40275900 |
| 58 | Postnatal microcephaly (HP:0005484) | 2.39797217 |
| 59 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.37217500 |
| 60 | Vertebral compression fractures (HP:0002953) | 2.36731588 |
| 61 | Respiratory difficulties (HP:0002880) | 2.34899920 |
| 62 | Retinal dysplasia (HP:0007973) | 2.34666149 |
| 63 | CNS demyelination (HP:0007305) | 2.34242833 |
| 64 | Lactic acidosis (HP:0003128) | 2.33326175 |
| 65 | Microvesicular hepatic steatosis (HP:0001414) | 2.28693757 |
| 66 | Respiratory failure (HP:0002878) | 2.28241186 |
| 67 | Generalized amyotrophy (HP:0003700) | 2.27360925 |
| 68 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.27046396 |
| 69 | Squamous cell carcinoma (HP:0002860) | 2.23510764 |
| 70 | Selective tooth agenesis (HP:0001592) | 2.23284963 |
| 71 | Truncus arteriosus (HP:0001660) | 2.23218933 |
| 72 | Turricephaly (HP:0000262) | 2.23033238 |
| 73 | Abnormality of the umbilical cord (HP:0010881) | 2.21637627 |
| 74 | Unsteady gait (HP:0002317) | 2.21400405 |
| 75 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.18939267 |
| 76 | Hyperalaninemia (HP:0003348) | 2.18388188 |
| 77 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.18388188 |
| 78 | Abnormality of alanine metabolism (HP:0010916) | 2.18388188 |
| 79 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.18357900 |
| 80 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.18357900 |
| 81 | Progressive muscle weakness (HP:0003323) | 2.17183354 |
| 82 | Myopathic facies (HP:0002058) | 2.16406737 |
| 83 | Microretrognathia (HP:0000308) | 2.15595712 |
| 84 | Premature graying of hair (HP:0002216) | 2.15215896 |
| 85 | Patellar dislocation (HP:0002999) | 2.14018951 |
| 86 | Spinal cord compression (HP:0002176) | 2.12204498 |
| 87 | Abnormality of secondary sexual hair (HP:0009888) | 2.11679468 |
| 88 | Abnormality of the axillary hair (HP:0100134) | 2.11679468 |
| 89 | Morphological abnormality of the inner ear (HP:0011390) | 2.11209502 |
| 90 | Type I transferrin isoform profile (HP:0003642) | 2.10251708 |
| 91 | Athetosis (HP:0002305) | 2.10075501 |
| 92 | Leukodystrophy (HP:0002415) | 2.09721967 |
| 93 | Hyperparathyroidism (HP:0000843) | 2.09573585 |
| 94 | Increased muscle lipid content (HP:0009058) | 2.09061792 |
| 95 | Severe visual impairment (HP:0001141) | 2.07675804 |
| 96 | Ankle contracture (HP:0006466) | 2.06791255 |
| 97 | Elfin facies (HP:0004428) | 2.06524035 |
| 98 | Concave nail (HP:0001598) | 2.06046709 |
| 99 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.05866232 |
| 100 | Short nail (HP:0001799) | 2.04952753 |
| 101 | Upper limb amyotrophy (HP:0009129) | 2.04854478 |
| 102 | Distal upper limb amyotrophy (HP:0007149) | 2.04854478 |
| 103 | Premature skin wrinkling (HP:0100678) | 2.03203240 |
| 104 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.01112358 |
| 105 | Bowed forearm bones (HP:0003956) | 2.00053010 |
| 106 | Bowing of the arm (HP:0006488) | 2.00053010 |
| 107 | Peripheral hypomyelination (HP:0007182) | 1.99730991 |
| 108 | Aplastic anemia (HP:0001915) | 1.99568978 |
| 109 | Optic disc pallor (HP:0000543) | 1.97984438 |
| 110 | Bladder diverticulum (HP:0000015) | 1.95979293 |
| 111 | Renal duplication (HP:0000075) | 1.95930860 |
| 112 | Intestinal fistula (HP:0100819) | 1.94222967 |
| 113 | Asplenia (HP:0001746) | 1.93738971 |
| 114 | Genu recurvatum (HP:0002816) | 1.93364469 |
| 115 | Aplasia involving forearm bones (HP:0009822) | 1.93065605 |
| 116 | Absent forearm bone (HP:0003953) | 1.93065605 |
| 117 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.91795770 |
| 118 | Hyperthyroidism (HP:0000836) | 1.90998169 |
| 119 | Vaginal fistula (HP:0004320) | 1.90851209 |
| 120 | Long palpebral fissure (HP:0000637) | 1.90601427 |
| 121 | Elbow flexion contracture (HP:0002987) | 1.89030635 |
| 122 | Pancytopenia (HP:0001876) | 1.88951967 |
| 123 | Progressive external ophthalmoplegia (HP:0000590) | 1.88073760 |
| 124 | Spastic paraparesis (HP:0002313) | 1.87981001 |
| 125 | Congenital hip dislocation (HP:0001374) | 1.87041621 |
| 126 | Increased connective tissue (HP:0009025) | 1.85815822 |
| 127 | Aplasia of the musculature (HP:0100854) | 1.85180582 |
| 128 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.84741888 |
| 129 | Premature ovarian failure (HP:0008209) | 1.84430271 |
| 130 | Hypercalcemia (HP:0003072) | 1.83953091 |
| 131 | Mitral regurgitation (HP:0001653) | 1.82917963 |
| 132 | Self-mutilation (HP:0000742) | 1.82912001 |
| 133 | Triphalangeal thumb (HP:0001199) | 1.82108563 |
| 134 | Supernumerary spleens (HP:0009799) | 1.80591030 |
| 135 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.80292142 |
| 136 | Single umbilical artery (HP:0001195) | 1.80292142 |
| 137 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.80292142 |
| 138 | Spinal rigidity (HP:0003306) | 1.79242048 |
| 139 | Hypoplasia of the radius (HP:0002984) | 1.78488564 |
| 140 | Sensory axonal neuropathy (HP:0003390) | 1.77779249 |
| 141 | Fragile skin (HP:0001030) | 1.77536717 |
| 142 | Sparse lateral eyebrow (HP:0005338) | 1.77469431 |
| 143 | Patellar aplasia (HP:0006443) | 1.76000661 |
| 144 | Rectovaginal fistula (HP:0000143) | 1.75999381 |
| 145 | Rectal fistula (HP:0100590) | 1.75999381 |
| 146 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.75704503 |
| 147 | Abnormal trabecular bone morphology (HP:0100671) | 1.74672929 |
| 148 | Abnormality of the intrinsic pathway (HP:0010989) | 1.74527804 |
| 149 | Pointed chin (HP:0000307) | 1.74456424 |
| 150 | Horseshoe kidney (HP:0000085) | 1.74436451 |
| 151 | Akinesia (HP:0002304) | 1.74217017 |
| 152 | Shallow orbits (HP:0000586) | 1.73602420 |
| 153 | Coronal craniosynostosis (HP:0004440) | 1.72051277 |
| 154 | Abnormality of placental membranes (HP:0011409) | 1.71932472 |
| 155 | Amniotic constriction ring (HP:0009775) | 1.71932472 |
| 156 | Megaloblastic anemia (HP:0001889) | 1.71647257 |
| 157 | Urethral obstruction (HP:0000796) | 1.71318090 |
| 158 | Stridor (HP:0010307) | 1.71143373 |
| 159 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.71113285 |
| 160 | Abnormality of renal resorption (HP:0011038) | 1.70095580 |
| 161 | Rib fusion (HP:0000902) | 1.69220413 |
| 162 | Slender long bone (HP:0003100) | 1.69166348 |
| 163 | Abnormal protein glycosylation (HP:0012346) | 1.69159517 |
| 164 | Abnormal glycosylation (HP:0012345) | 1.69159517 |
| 165 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.69159517 |
| 166 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.69159517 |
| 167 | Abnormality of the preputium (HP:0100587) | 1.69028837 |
| 168 | Type II lissencephaly (HP:0007260) | 1.67743880 |
| 169 | Abnormal ciliary motility (HP:0012262) | 1.67408455 |
| 170 | Cerebellar dysplasia (HP:0007033) | 1.64302680 |
| 171 | Glossoptosis (HP:0000162) | 1.64061423 |
| 172 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.63547757 |
POLR3H 
