POLR3K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.44520239
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.93514172
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.54059929
4cullin deneddylation (GO:0010388)4.44094819
5proteasome assembly (GO:0043248)4.34812567
6protein deneddylation (GO:0000338)4.30770385
7respiratory electron transport chain (GO:0022904)4.23309472
8electron transport chain (GO:0022900)4.22698426
97-methylguanosine mRNA capping (GO:0006370)4.09737274
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09143389
11maturation of SSU-rRNA (GO:0030490)4.08609255
12ribosomal small subunit biogenesis (GO:0042274)4.06307109
13RNA capping (GO:0036260)4.05299923
147-methylguanosine RNA capping (GO:0009452)4.05299923
15DNA deamination (GO:0045006)4.01015124
16chaperone-mediated protein transport (GO:0072321)3.99030789
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.95158811
18viral transcription (GO:0019083)3.93486261
19cotranslational protein targeting to membrane (GO:0006613)3.92879325
20rRNA modification (GO:0000154)3.91296383
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88403887
22ATP synthesis coupled proton transport (GO:0015986)3.88403887
23protein neddylation (GO:0045116)3.85619230
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.84692958
25protein targeting to ER (GO:0045047)3.84412022
26translational termination (GO:0006415)3.83327468
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83059725
28ribosomal large subunit biogenesis (GO:0042273)3.77059531
29* termination of RNA polymerase III transcription (GO:0006386)3.74406885
30* transcription elongation from RNA polymerase III promoter (GO:0006385)3.74406885
31CENP-A containing nucleosome assembly (GO:0034080)3.71048287
32protein localization to endoplasmic reticulum (GO:0070972)3.69074081
33protein complex biogenesis (GO:0070271)3.65868337
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.64367817
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64134873
36respiratory chain complex IV assembly (GO:0008535)3.62872340
37maturation of 5.8S rRNA (GO:0000460)3.61574470
38water-soluble vitamin biosynthetic process (GO:0042364)3.60322650
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58619098
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57635244
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57175756
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57175756
43signal peptide processing (GO:0006465)3.56868067
44telomere maintenance via semi-conservative replication (GO:0032201)3.55109713
45chromatin remodeling at centromere (GO:0031055)3.49778210
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47186903
47negative regulation of ligase activity (GO:0051352)3.47186903
48protein targeting to mitochondrion (GO:0006626)3.46594694
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46501251
50establishment of integrated proviral latency (GO:0075713)3.45884480
51spliceosomal snRNP assembly (GO:0000387)3.44278298
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.43905191
53NADH dehydrogenase complex assembly (GO:0010257)3.43905191
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43905191
55DNA strand elongation involved in DNA replication (GO:0006271)3.40572907
56translational elongation (GO:0006414)3.40031026
57purine nucleobase biosynthetic process (GO:0009113)3.38621346
58mitochondrial respiratory chain complex assembly (GO:0033108)3.37900251
59protein-cofactor linkage (GO:0018065)3.37013830
60histone exchange (GO:0043486)3.35147378
61viral mRNA export from host cell nucleus (GO:0046784)3.33737756
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33385983
63transcription-coupled nucleotide-excision repair (GO:0006283)3.32846166
64peptidyl-histidine modification (GO:0018202)3.32733586
65translation (GO:0006412)3.31885682
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31595868
67DNA strand elongation (GO:0022616)3.30619691
682-deoxyribonucleotide biosynthetic process (GO:0009265)3.30387465
69deoxyribose phosphate biosynthetic process (GO:0046385)3.30387465
70deoxyribonucleotide biosynthetic process (GO:0009263)3.29384496
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29181626
72nucleobase biosynthetic process (GO:0046112)3.29172879
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28922698
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28922698
75establishment of protein localization to mitochondrion (GO:0072655)3.28234051
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.27625572
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.27625572
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.27625572
79guanosine-containing compound biosynthetic process (GO:1901070)3.26814699
80ribonucleoprotein complex biogenesis (GO:0022613)3.26403616
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26396031
82regulation of mitochondrial translation (GO:0070129)3.25463491
83telomere maintenance via recombination (GO:0000722)3.25185501
84ATP biosynthetic process (GO:0006754)3.23547445
85spliceosomal complex assembly (GO:0000245)3.22456123
86regulation of cellular amino acid metabolic process (GO:0006521)3.21699535
87mitotic metaphase plate congression (GO:0007080)3.20812658
88cytochrome complex assembly (GO:0017004)3.20531476
89translational initiation (GO:0006413)3.19965990
90rRNA methylation (GO:0031167)3.19872661
91cellular protein complex disassembly (GO:0043624)3.19306613
92transcription elongation from RNA polymerase I promoter (GO:0006362)3.19254523
93DNA replication checkpoint (GO:0000076)3.18670903
94protein localization to mitochondrion (GO:0070585)3.18252167
95purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17766333
96cellular component biogenesis (GO:0044085)3.16862264
97termination of RNA polymerase I transcription (GO:0006363)3.16071320
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.15776385
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15622277
100viral life cycle (GO:0019058)3.15015074
101mitotic recombination (GO:0006312)3.14936934
102mitochondrial RNA metabolic process (GO:0000959)3.14484955
103protein K6-linked ubiquitination (GO:0085020)3.14304086
104signal transduction involved in DNA damage checkpoint (GO:0072422)3.14095161
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.14095161
106signal transduction involved in cell cycle checkpoint (GO:0072395)3.13742528
107GTP biosynthetic process (GO:0006183)3.12793621
108replication fork processing (GO:0031297)3.12262503
109tRNA processing (GO:0008033)3.07791205
110transcription elongation from RNA polymerase II promoter (GO:0006368)3.07560074
111intracellular protein transmembrane import (GO:0044743)3.06489791
112regulation of nuclear cell cycle DNA replication (GO:0033262)3.05531303
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05455241
114DNA damage response, detection of DNA damage (GO:0042769)3.04149664
115nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04019295
116pseudouridine synthesis (GO:0001522)3.02086861
117rRNA processing (GO:0006364)3.01862149
118oxidative phosphorylation (GO:0006119)2.99762230
119DNA replication-independent nucleosome assembly (GO:0006336)2.98734240
120DNA replication-independent nucleosome organization (GO:0034724)2.98734240
121nucleotide-excision repair, DNA gap filling (GO:0006297)2.96695946
122hydrogen ion transmembrane transport (GO:1902600)2.95646935
123DNA ligation (GO:0006266)2.94646759
124positive regulation of ligase activity (GO:0051351)2.94125912
125establishment of viral latency (GO:0019043)2.93773295
126ncRNA processing (GO:0034470)2.92816649
127ribonucleoside triphosphate biosynthetic process (GO:0009201)2.92486420
128telomere maintenance via telomere lengthening (GO:0010833)2.90656805
129rRNA metabolic process (GO:0016072)2.90150226
130ncRNA metabolic process (GO:0034660)2.89895301
131behavioral response to nicotine (GO:0035095)2.85500222
132inner mitochondrial membrane organization (GO:0007007)2.83900395
133negative regulation of DNA-dependent DNA replication (GO:2000104)2.83116275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.45530693
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.96641010
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.15230483
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.03195409
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.63938849
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.63051093
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.56814052
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.51611972
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.34775675
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.32721101
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23719979
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16713387
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84815203
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82142402
15* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80970367
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79915066
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73855205
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73560719
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61801835
20VDR_23849224_ChIP-Seq_CD4+_Human2.60908484
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55871228
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41130791
23ELK1_19687146_ChIP-ChIP_HELA_Human2.38743007
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38041198
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36260531
26ZNF274_21170338_ChIP-Seq_K562_Hela2.34590113
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31191776
28DCP1A_22483619_ChIP-Seq_HELA_Human2.31124490
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28669332
30* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.23833623
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23318015
32FOXP3_21729870_ChIP-Seq_TREG_Human2.22700687
33* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21623927
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.19884951
35XRN2_22483619_ChIP-Seq_HELA_Human2.07148357
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03979049
37HOXB4_20404135_ChIP-ChIP_EML_Mouse2.02918872
38TTF2_22483619_ChIP-Seq_HELA_Human1.96619679
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95619162
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94069892
41GABP_19822575_ChIP-Seq_HepG2_Human1.89394277
42* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86325009
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77136520
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.76437230
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70407431
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.68096351
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67359954
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61446466
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52391264
50* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51208863
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50764900
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45070903
53MYC_18940864_ChIP-ChIP_HL60_Human1.40912103
54FUS_26573619_Chip-Seq_HEK293_Human1.39864827
55* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35515036
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.34573685
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.28101470
58CIITA_25753668_ChIP-Seq_RAJI_Human1.27725730
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27489160
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26001393
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25307812
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24852943
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.23140207
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22431688
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21458992
66TP53_22573176_ChIP-Seq_HFKS_Human1.20346774
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19862733
68EWS_26573619_Chip-Seq_HEK293_Human1.17912782
69AR_21909140_ChIP-Seq_LNCAP_Human1.11024886
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10341071
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08579949
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.07338481
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.04706190
74IRF1_19129219_ChIP-ChIP_H3396_Human1.04662237
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03492555
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02702815
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02641123
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02175506
79KDM5A_27292631_Chip-Seq_BREAST_Human1.00422526
80* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99195965
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99141658
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98994918
83IGF1R_20145208_ChIP-Seq_DFB_Human0.94943911
84* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94100223
85SOX2_16153702_ChIP-ChIP_HESCs_Human0.92830291
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91400342
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91260185
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.91260185
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90112560
90* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89990609
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89853427
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89772516
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.89749251
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89486741
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.89115542
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88998524
97TAF15_26573619_Chip-Seq_HEK293_Human0.88060018
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87550238
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86403992
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85683131
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84933354
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.84174732
103CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83943976
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83269347
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82716347
106VDR_22108803_ChIP-Seq_LS180_Human0.82394847
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82356158
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81892683
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79508500
110AR_20517297_ChIP-Seq_VCAP_Human0.79476143
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79341938
112NCOR_22424771_ChIP-Seq_293T_Human0.78571670
113SPI1_23547873_ChIP-Seq_NB4_Human0.78442333
114NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78412258
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78067086
116CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.77262148
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74050974
118ER_23166858_ChIP-Seq_MCF-7_Human0.73298911
119HTT_18923047_ChIP-ChIP_STHdh_Human0.73214986
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72025433
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.70913352
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70666522
123SOX2_18555785_ChIP-Seq_MESCs_Mouse0.70624228
124SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68989713
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67447287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.33042585
2MP0003693_abnormal_embryo_hatching3.61883394
3MP0001188_hyperpigmentation3.05471420
4MP0010094_abnormal_chromosome_stability3.04105685
5MP0001529_abnormal_vocalization2.92780383
6MP0004957_abnormal_blastocyst_morpholog2.88985152
7MP0008058_abnormal_DNA_repair2.88633654
8MP0003806_abnormal_nucleotide_metabolis2.70743001
9MP0008057_abnormal_DNA_replication2.57524934
10MP0003077_abnormal_cell_cycle2.55562672
11MP0003123_paternal_imprinting2.52373053
12MP0008007_abnormal_cellular_replicative2.28400787
13MP0003111_abnormal_nucleus_morphology2.28134126
14MP0006292_abnormal_olfactory_placode2.20318628
15MP0002163_abnormal_gland_morphology2.19773099
16MP0008932_abnormal_embryonic_tissue2.11544259
17MP0003186_abnormal_redox_activity2.09413221
18MP0003011_delayed_dark_adaptation2.05100818
19MP0005409_darkened_coat_color1.99682518
20MP0008877_abnormal_DNA_methylation1.94674221
21MP0000015_abnormal_ear_pigmentation1.94267930
22MP0003787_abnormal_imprinting1.90054117
23MP0003880_abnormal_central_pattern1.89977931
24MP0001905_abnormal_dopamine_level1.89523743
25MP0003121_genomic_imprinting1.84856580
26MP0002095_abnormal_skin_pigmentation1.80191025
27MP0004147_increased_porphyrin_level1.79902659
28MP0001986_abnormal_taste_sensitivity1.73886735
29MP0000372_irregular_coat_pigmentation1.72344742
30MP0003195_calcinosis1.71667101
31MP0002938_white_spotting1.68251049
32MP0003786_premature_aging1.65250559
33MP0002638_abnormal_pupillary_reflex1.64725754
34MP0009697_abnormal_copulation1.63722115
35MP0002102_abnormal_ear_morphology1.61267851
36MP0002396_abnormal_hematopoietic_system1.60819438
37MP0008872_abnormal_physiological_respon1.56928948
38MP0000566_synostosis1.56483924
39MP0002837_dystrophic_cardiac_calcinosis1.52063560
40MP0006276_abnormal_autonomic_nervous1.51561065
41MP0003315_abnormal_perineum_morphology1.47520481
42MP0005551_abnormal_eye_electrophysiolog1.47391431
43MP0005379_endocrine/exocrine_gland_phen1.46496060
44MP0001293_anophthalmia1.45918435
45MP0003718_maternal_effect1.44273310
46MP0005174_abnormal_tail_pigmentation1.41664486
47MP0009046_muscle_twitch1.37782813
48MP0008875_abnormal_xenobiotic_pharmacok1.31000748
49MP0002876_abnormal_thyroid_physiology1.30047835
50MP0002736_abnormal_nociception_after1.29603468
51MP0003122_maternal_imprinting1.28393716
52MP0000490_abnormal_crypts_of1.24467970
53MP0009745_abnormal_behavioral_response1.20808070
54MP0004133_heterotaxia1.17835541
55MP0006054_spinal_hemorrhage1.15281758
56MP0008995_early_reproductive_senescence1.14262747
57MP0002160_abnormal_reproductive_system1.13737349
58MP0002234_abnormal_pharynx_morphology1.12059108
59MP0002751_abnormal_autonomic_nervous1.11702304
60MP0003646_muscle_fatigue1.09931364
61MP0001968_abnormal_touch/_nociception1.09272349
62MP0006036_abnormal_mitochondrial_physio1.08479922
63MP0010386_abnormal_urinary_bladder1.06890925
64MP0005075_abnormal_melanosome_morpholog1.06380961
65MP0009333_abnormal_splenocyte_physiolog1.05946926
66MP0000681_abnormal_thyroid_gland1.02349405
67MP0000631_abnormal_neuroendocrine_gland1.00404809
68MP0006072_abnormal_retinal_apoptosis0.99113759
69MP0002653_abnormal_ependyma_morphology0.97888933
70MP0005423_abnormal_somatic_nervous0.97195944
71MP0005084_abnormal_gallbladder_morpholo0.95204359
72MP0002132_abnormal_respiratory_system0.94527097
73MP0000678_abnormal_parathyroid_gland0.94065457
74MP0003763_abnormal_thymus_physiology0.92918678
75MP0005220_abnormal_exocrine_pancreas0.92530119
76MP0003119_abnormal_digestive_system0.92038333
77MP0000358_abnormal_cell_content/0.91805388
78MP0006035_abnormal_mitochondrial_morpho0.91455549
79MP0004142_abnormal_muscle_tone0.90803294
80MP0005671_abnormal_response_to0.90704646
81MP0002272_abnormal_nervous_system0.90263459
82MP0002277_abnormal_respiratory_mucosa0.89947609
83MP0004885_abnormal_endolymph0.89287511
84MP0000350_abnormal_cell_proliferation0.89164044
85MP0003937_abnormal_limbs/digits/tail_de0.87518088
86MP0005389_reproductive_system_phenotype0.86881472
87MP0003698_abnormal_male_reproductive0.86768203
88MP0005408_hypopigmentation0.86630793
89MP0004145_abnormal_muscle_electrophysio0.86555795
90MP0005171_absent_coat_pigmentation0.84257071
91MP0010030_abnormal_orbit_morphology0.83782795
92MP0005646_abnormal_pituitary_gland0.83069772
93MP0000049_abnormal_middle_ear0.82273898
94MP0004742_abnormal_vestibular_system0.82103511
95MP0002177_abnormal_outer_ear0.81860604
96MP0002210_abnormal_sex_determination0.80883939
97MP0003890_abnormal_embryonic-extraembry0.80449094
98MP0005645_abnormal_hypothalamus_physiol0.80338919
99MP0001186_pigmentation_phenotype0.80107281
100MP0003137_abnormal_impulse_conducting0.79510603
101MP0005332_abnormal_amino_acid0.79095547
102MP0008789_abnormal_olfactory_epithelium0.78809389
103MP0005410_abnormal_fertilization0.78726413
104MP0000427_abnormal_hair_cycle0.77517619
105MP0003938_abnormal_ear_development0.76626443
106MP0000313_abnormal_cell_death0.76170859
107MP0002735_abnormal_chemical_nociception0.76153331
108MP0003567_abnormal_fetal_cardiomyocyte0.76000311
109MP0001324_abnormal_eye_pigmentation0.75688452
110MP0002184_abnormal_innervation0.75237972
111MP0000778_abnormal_nervous_system0.74545604
112MP0002734_abnormal_mechanical_nocicepti0.73530676
113MP0000647_abnormal_sebaceous_gland0.73506438
114MP0005636_abnormal_mineral_homeostasis0.72065856
115MP0004808_abnormal_hematopoietic_stem0.70866924
116MP0003252_abnormal_bile_duct0.70611919
117MP0002572_abnormal_emotion/affect_behav0.69428522
118MP0003136_yellow_coat_color0.69151807
119MP0001764_abnormal_homeostasis0.68684274
120MP0001485_abnormal_pinna_reflex0.68440382
121MP0005195_abnormal_posterior_eye0.67637295
122MP0001119_abnormal_female_reproductive0.67048472
123MP0001730_embryonic_growth_arrest0.66753347
124MP0005395_other_phenotype0.66450705
125MP0001286_abnormal_eye_development0.66287109
126MP0001919_abnormal_reproductive_system0.66220788
127MP0001664_abnormal_digestion0.65776310
128MP0000653_abnormal_sex_gland0.65165668
129MP0005253_abnormal_eye_physiology0.64704775
130MP0000026_abnormal_inner_ear0.64575874
131MP0001929_abnormal_gametogenesis0.62633018
132MP0001145_abnormal_male_reproductive0.62610087
133MP0002009_preneoplasia0.62524639
134MP0002398_abnormal_bone_marrow0.61307082
135MP0003943_abnormal_hepatobiliary_system0.61226296

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.01946672
2Acute necrotizing encephalopathy (HP:0006965)3.99728179
3Abnormality of cells of the erythroid lineage (HP:0012130)3.95215054
4Birth length less than 3rd percentile (HP:0003561)3.92364699
5Increased hepatocellular lipid droplets (HP:0006565)3.84199247
6Abnormal number of erythroid precursors (HP:0012131)3.82150138
7Aplastic anemia (HP:0001915)3.74478749
8Abnormal mitochondria in muscle tissue (HP:0008316)3.66429525
9Increased CSF lactate (HP:0002490)3.63731189
10Reticulocytopenia (HP:0001896)3.57265741
11Hepatocellular necrosis (HP:0001404)3.56884965
12Type I transferrin isoform profile (HP:0003642)3.36280792
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35950076
14Progressive macrocephaly (HP:0004481)3.35684353
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.29748997
16Abnormality of alanine metabolism (HP:0010916)3.29748997
17Hyperalaninemia (HP:0003348)3.29748997
18Lipid accumulation in hepatocytes (HP:0006561)3.21282485
19Cerebral hypomyelination (HP:0006808)3.16414731
20Renal Fanconi syndrome (HP:0001994)3.14224158
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.11108697
22Cerebral edema (HP:0002181)3.07421463
233-Methylglutaconic aciduria (HP:0003535)3.06021952
24Hepatic necrosis (HP:0002605)3.02991076
25Abnormality of glycolysis (HP:0004366)2.91633599
26Increased serum pyruvate (HP:0003542)2.91633599
27Molar tooth sign on MRI (HP:0002419)2.91394480
28Abnormality of midbrain morphology (HP:0002418)2.91394480
29Acute encephalopathy (HP:0006846)2.89435411
30Exertional dyspnea (HP:0002875)2.88155131
31Increased serum lactate (HP:0002151)2.87292223
3211 pairs of ribs (HP:0000878)2.86081956
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85348696
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85348696
35Microvesicular hepatic steatosis (HP:0001414)2.77958395
36Pendular nystagmus (HP:0012043)2.69133521
37Macrocytic anemia (HP:0001972)2.66916393
38Respiratory difficulties (HP:0002880)2.61499472
39Oral leukoplakia (HP:0002745)2.58398274
40Pallor (HP:0000980)2.58270281
41Methylmalonic acidemia (HP:0002912)2.52386454
42Abnormality of the preputium (HP:0100587)2.46751234
43Abnormal glycosylation (HP:0012345)2.44050751
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44050751
45Abnormal protein N-linked glycosylation (HP:0012347)2.44050751
46Abnormal protein glycosylation (HP:0012346)2.44050751
47Exercise intolerance (HP:0003546)2.42583809
48Colon cancer (HP:0003003)2.40639650
49Congenital, generalized hypertrichosis (HP:0004540)2.38464991
50Increased intramyocellular lipid droplets (HP:0012240)2.35063994
51Pancreatic cysts (HP:0001737)2.33079113
52True hermaphroditism (HP:0010459)2.32641345
53Abnormality of the labia minora (HP:0012880)2.32339131
54Medial flaring of the eyebrow (HP:0010747)2.32238732
55Methylmalonic aciduria (HP:0012120)2.32180150
56Aplasia/hypoplasia of the uterus (HP:0008684)2.31997831
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31782417
58Pancreatic fibrosis (HP:0100732)2.31079312
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30612382
60Congenital stationary night blindness (HP:0007642)2.29187273
61Leukodystrophy (HP:0002415)2.27380240
62Lethargy (HP:0001254)2.26565985
63Abnormal lung lobation (HP:0002101)2.26484964
64Meckel diverticulum (HP:0002245)2.24726764
65Chromsome breakage (HP:0040012)2.24210439
66Breast hypoplasia (HP:0003187)2.23930608
67Sclerocornea (HP:0000647)2.23014300
68Lactic acidosis (HP:0003128)2.22280661
69Abnormal hair whorl (HP:0010721)2.21008580
70Abnormality of the ileum (HP:0001549)2.16423522
71Type 2 muscle fiber atrophy (HP:0003554)2.15568477
72Reduced antithrombin III activity (HP:0001976)2.14500773
73Gait imbalance (HP:0002141)2.13339737
74Hypothermia (HP:0002045)2.11983947
75Nephronophthisis (HP:0000090)2.11493894
76Severe visual impairment (HP:0001141)2.11324829
77Absent thumb (HP:0009777)2.11046282
78Rough bone trabeculation (HP:0100670)2.10763177
79Patellar aplasia (HP:0006443)2.10364356
80Nephrogenic diabetes insipidus (HP:0009806)2.09153403
81Congenital primary aphakia (HP:0007707)2.06535103
82Abnormality of chromosome stability (HP:0003220)2.05471081
83Abnormality of serum amino acid levels (HP:0003112)2.05328461
84Thrombocytosis (HP:0001894)2.03841848
85Poor suck (HP:0002033)2.03840336
86Respiratory failure (HP:0002878)2.02582957
87Optic disc pallor (HP:0000543)2.02379523
88Hyperglycinemia (HP:0002154)2.00484287
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97453918
90CNS hypomyelination (HP:0003429)1.96828804
91Abnormality of the heme biosynthetic pathway (HP:0010472)1.95658146
92Pancytopenia (HP:0001876)1.95518332
93Myelodysplasia (HP:0002863)1.94880161
94Aplasia/Hypoplasia of the patella (HP:0006498)1.94299188
95Abnormality of renal resorption (HP:0011038)1.94252607
96CNS demyelination (HP:0007305)1.93626800
97Poor head control (HP:0002421)1.93516589
98Nephroblastoma (Wilms tumor) (HP:0002667)1.93058878
99Premature graying of hair (HP:0002216)1.92929649
100Abnormality of the pons (HP:0007361)1.91669552
101Hypoplasia of the pons (HP:0012110)1.91207258
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.91181709
103Hypoplasia of the uterus (HP:0000013)1.88643874
104Bone marrow hypocellularity (HP:0005528)1.87860977
105Embryonal renal neoplasm (HP:0011794)1.87125211
106Hyperglycinuria (HP:0003108)1.86125514
107Testicular atrophy (HP:0000029)1.85684962
108Large for gestational age (HP:0001520)1.85261763
109Degeneration of anterior horn cells (HP:0002398)1.85155067
110Abnormality of the anterior horn cell (HP:0006802)1.85155067
111Muscle fiber atrophy (HP:0100295)1.84180251
112Unsteady gait (HP:0002317)1.79845160
113Abnormality of urine glucose concentration (HP:0011016)1.79412092
114Glycosuria (HP:0003076)1.79412092
115Duodenal stenosis (HP:0100867)1.79334880
116Small intestinal stenosis (HP:0012848)1.79334880
117Abnormal trabecular bone morphology (HP:0100671)1.78586826
118Concave nail (HP:0001598)1.78482298
119Horseshoe kidney (HP:0000085)1.78342726
120Triphalangeal thumb (HP:0001199)1.78308998
121Bilateral microphthalmos (HP:0007633)1.77545329
122Microretrognathia (HP:0000308)1.76044577
123Postnatal microcephaly (HP:0005484)1.75907736
124Abnormality of the renal cortex (HP:0011035)1.73784768
125Secondary amenorrhea (HP:0000869)1.73535689
126Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73336994
127Depressed nasal ridge (HP:0000457)1.73043856
128Cleft eyelid (HP:0000625)1.71672203
129Increased muscle lipid content (HP:0009058)1.71316313
130Amniotic constriction ring (HP:0009775)1.70973976
131Anencephaly (HP:0002323)1.68521372
132Abnormality of the renal medulla (HP:0100957)1.68186011
133Male pseudohermaphroditism (HP:0000037)1.67882396
134Furrowed tongue (HP:0000221)1.64647590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.82473770
2BUB13.81071607
3VRK23.59676190
4EIF2AK13.16544071
5VRK12.81033443
6MAP3K122.64119645
7SRPK12.64006306
8CCNB12.53025383
9CASK2.39498332
10CDC72.30717253
11EIF2AK32.30701924
12MKNK12.27345974
13TNIK1.98079949
14WEE11.95163619
15NEK11.91323028
16MAP2K71.86134852
17GRK11.80687996
18MKNK21.79682409
19TRIM281.75197116
20TLK11.74780608
21WNK31.74065556
22CDK191.72694323
23PLK31.72117785
24TSSK61.71150831
25NME11.70576986
26CDK81.69881484
27NME21.65062108
28WNK41.61522241
29BRSK21.59531935
30ERBB31.49967207
31PDK21.40238778
32PLK41.38848710
33DYRK21.37814807
34MAPK131.33030481
35INSRR1.32455587
36PLK21.29742607
37TAF11.28752848
38BCKDK1.28191537
39MAP4K21.28013014
40PIM21.27885555
41ACVR1B1.27409390
42SIK31.25776462
43PASK1.22772372
44ZAK1.22097348
45MST41.21281697
46BCR1.20222197
47BRAF1.18305923
48BMPR1B1.18097712
49PLK11.13234153
50BRSK11.11423759
51MARK11.10976067
52BMPR21.10390286
53ADRBK21.07787549
54YES11.06119766
55DYRK31.05214000
56PNCK1.04672377
57IRAK41.04275516
58EIF2AK20.97342286
59CLK10.95303499
60LIMK10.93307204
61NUAK10.91883703
62PINK10.91003059
63AURKB0.90613320
64TEC0.85679275
65ATR0.85309657
66CHEK20.80013224
67DAPK10.79376967
68PBK0.78698780
69MYLK0.78093609
70CSNK1G10.77027105
71AURKA0.75843824
72STK390.75831451
73TGFBR10.72934849
74MAP3K60.71999421
75CSNK1G20.71106748
76RPS6KA50.70515827
77MAPKAPK50.68664154
78AKT30.67779428
79OXSR10.66186765
80CSNK2A10.64629382
81CSNK1G30.63459846
82TXK0.62525021
83TIE10.59767090
84TTK0.58848401
85MAP3K40.58771187
86CSNK2A20.54249615
87CSNK1A1L0.52609612
88ARAF0.52396181
89NEK60.52116490
90ALK0.51949379
91FRK0.51741799
92STK240.50674295
93TESK20.50067482
94NEK20.49392031
95MAP2K60.48741917
96STK40.48484028
97MINK10.48059438
98SCYL20.47645753
99RPS6KB20.46373454
100CDK70.45489234
101CSNK1E0.43196394
102CDK30.42816465
103CDK180.41007860
104CSNK1A10.39776051
105PHKG10.38796150
106PHKG20.38796150
107TESK10.38628149
108MUSK0.38025930
109ILK0.37661485
110ATM0.37455210
111ADRBK10.37404645
112MAPKAPK30.37040358
113CAMKK20.36552110
114CHEK10.36499541
115SYK0.36355855
116IRAK30.36050134
117LYN0.35579539
118STK30.34578479
119CDK140.34484091
120ABL20.32158751
121CDK11A0.32144871
122UHMK10.32056473
123KDR0.31983695
124IKBKB0.31935297
125PRKCG0.31763661
126RPS6KB10.31738030
127PRKCI0.31263656
128CDK150.31107358
129MAPK150.30764948
130CDK10.30161130
131DYRK1A0.29914946
132DAPK20.28266177
133TAOK30.26895687

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.20727534
2Proteasome_Homo sapiens_hsa030504.11437553
3* RNA polymerase_Homo sapiens_hsa030203.64031918
4Protein export_Homo sapiens_hsa030603.61233146
5DNA replication_Homo sapiens_hsa030303.55050680
6Mismatch repair_Homo sapiens_hsa034303.12200220
7Homologous recombination_Homo sapiens_hsa034402.87583096
8Oxidative phosphorylation_Homo sapiens_hsa001902.83755473
9Spliceosome_Homo sapiens_hsa030402.80012366
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66286791
11Parkinsons disease_Homo sapiens_hsa050122.53597848
12* Pyrimidine metabolism_Homo sapiens_hsa002402.52571788
13Nucleotide excision repair_Homo sapiens_hsa034202.51750885
14Base excision repair_Homo sapiens_hsa034102.28501956
15Basal transcription factors_Homo sapiens_hsa030222.11406229
16RNA transport_Homo sapiens_hsa030132.05186552
17Huntingtons disease_Homo sapiens_hsa050162.03971511
18Cell cycle_Homo sapiens_hsa041101.89817046
19Fanconi anemia pathway_Homo sapiens_hsa034601.80352959
20RNA degradation_Homo sapiens_hsa030181.75159762
21Alzheimers disease_Homo sapiens_hsa050101.73643791
22Non-homologous end-joining_Homo sapiens_hsa034501.71642558
23* Purine metabolism_Homo sapiens_hsa002301.58071557
24Selenocompound metabolism_Homo sapiens_hsa004501.57602283
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34297058
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30165527
27* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28362083
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24729860
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24559569
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24556953
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19728815
32Propanoate metabolism_Homo sapiens_hsa006401.17437782
33Sulfur relay system_Homo sapiens_hsa041221.12378803
34mRNA surveillance pathway_Homo sapiens_hsa030151.08454661
35Butanoate metabolism_Homo sapiens_hsa006501.02456119
36Nitrogen metabolism_Homo sapiens_hsa009101.00403622
37Pyruvate metabolism_Homo sapiens_hsa006200.99332246
38Vibrio cholerae infection_Homo sapiens_hsa051100.97562351
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97056281
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90718992
41* Epstein-Barr virus infection_Homo sapiens_hsa051690.90260154
42One carbon pool by folate_Homo sapiens_hsa006700.89416080
43Collecting duct acid secretion_Homo sapiens_hsa049660.89234028
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86661916
45N-Glycan biosynthesis_Homo sapiens_hsa005100.85975238
46Linoleic acid metabolism_Homo sapiens_hsa005910.83302229
47Tryptophan metabolism_Homo sapiens_hsa003800.81868536
48p53 signaling pathway_Homo sapiens_hsa041150.81394064
49Peroxisome_Homo sapiens_hsa041460.79726687
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.79660112
51Phototransduction_Homo sapiens_hsa047440.78240531
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77888067
53Caffeine metabolism_Homo sapiens_hsa002320.74377763
54Oocyte meiosis_Homo sapiens_hsa041140.72701930
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72059778
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71528140
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70991874
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70108779
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68969654
60Sulfur metabolism_Homo sapiens_hsa009200.66195453
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62837787
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58824154
63Vitamin B6 metabolism_Homo sapiens_hsa007500.57579625
64Folate biosynthesis_Homo sapiens_hsa007900.55599221
65Steroid biosynthesis_Homo sapiens_hsa001000.55515053
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55088196
67Regulation of autophagy_Homo sapiens_hsa041400.54324231
68Nicotine addiction_Homo sapiens_hsa050330.54226677
69Alcoholism_Homo sapiens_hsa050340.54013782
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53707092
71Olfactory transduction_Homo sapiens_hsa047400.52915930
72Chemical carcinogenesis_Homo sapiens_hsa052040.51334672
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51054642
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50635172
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50369598
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49914970
77Vitamin digestion and absorption_Homo sapiens_hsa049770.49387081
78Systemic lupus erythematosus_Homo sapiens_hsa053220.48031378
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.47992121
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47637381
81Serotonergic synapse_Homo sapiens_hsa047260.46984578
82* Metabolic pathways_Homo sapiens_hsa011000.46621747
83Sphingolipid metabolism_Homo sapiens_hsa006000.44784161
84Antigen processing and presentation_Homo sapiens_hsa046120.43795352
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43004699
86Retinol metabolism_Homo sapiens_hsa008300.42910829
87Cardiac muscle contraction_Homo sapiens_hsa042600.42771747
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.41381079
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40480328
90Arachidonic acid metabolism_Homo sapiens_hsa005900.40368787
91Fatty acid elongation_Homo sapiens_hsa000620.40169540
92Primary immunodeficiency_Homo sapiens_hsa053400.38620930
93Herpes simplex infection_Homo sapiens_hsa051680.38531037
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37936911
95Rheumatoid arthritis_Homo sapiens_hsa053230.37569341
96beta-Alanine metabolism_Homo sapiens_hsa004100.37428999
97Synaptic vesicle cycle_Homo sapiens_hsa047210.36720973
98Phagosome_Homo sapiens_hsa041450.34429301
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34293303
100Taste transduction_Homo sapiens_hsa047420.34183795
101Type I diabetes mellitus_Homo sapiens_hsa049400.33225743
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30227412
103Carbon metabolism_Homo sapiens_hsa012000.28236590
104Glutathione metabolism_Homo sapiens_hsa004800.27483490
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27366932
106Ether lipid metabolism_Homo sapiens_hsa005650.27281041
107Autoimmune thyroid disease_Homo sapiens_hsa053200.26028846
108Arginine and proline metabolism_Homo sapiens_hsa003300.25873308
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24805373
110Allograft rejection_Homo sapiens_hsa053300.24606854
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.24384628
112Viral carcinogenesis_Homo sapiens_hsa052030.24292119
113Fatty acid degradation_Homo sapiens_hsa000710.24090597
114Fatty acid metabolism_Homo sapiens_hsa012120.23633125
115Pentose phosphate pathway_Homo sapiens_hsa000300.23182216
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22397183
117Legionellosis_Homo sapiens_hsa051340.22129192
118Thyroid cancer_Homo sapiens_hsa052160.21504704
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.20545405
120Dopaminergic synapse_Homo sapiens_hsa047280.20464755
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20228177
122Amphetamine addiction_Homo sapiens_hsa050310.19762504
123Biosynthesis of amino acids_Homo sapiens_hsa012300.19298718
124Tyrosine metabolism_Homo sapiens_hsa003500.18733688
125Fat digestion and absorption_Homo sapiens_hsa049750.17223872
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16715611
127Long-term depression_Homo sapiens_hsa047300.16634832
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16462415
129Colorectal cancer_Homo sapiens_hsa052100.15249907
130Graft-versus-host disease_Homo sapiens_hsa053320.13757309
131Shigellosis_Homo sapiens_hsa051310.12555785
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10909429
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.10689694
134Other glycan degradation_Homo sapiens_hsa005110.10631742
135Measles_Homo sapiens_hsa051620.10443331
136Asthma_Homo sapiens_hsa053100.10129158
137HTLV-I infection_Homo sapiens_hsa051660.09810727
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08749032
139Hematopoietic cell lineage_Homo sapiens_hsa046400.08718192

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